NEW! Lonafarnib Pre-clinical Drug Supply Program

NEW! Lonafarnib Pre-clinical Drug Supply Program


Home » Medical Research » NEW! Lonafarnib Pre-clinical Drug Supply Program

July 2015: Lonafarnib Now Available for Research

PRF is making the farnesyltransferase inhibitor lonafarnib available to the research community. Our goal is to support preclinical studies to further investigate the effects of lonafarnib on Progeria.

It is PRF's steadfast mission to find better treatments and a cure for children with Progeria. Lonafarnib has been shown to benefit some aspects of the disease clinically, (Gordon et al, PNAS, 2012) as well as influence increased estimated lifespan, (Gordon et al, Circulation, 2014) but it is not curative. As new compounds are identified with the potential to ameliorate HGPS, we anticipate the need to test these compounds in combination with lonafarnib in vitro and in animal models.

Many thanks to the pharmaceutical company Merck for making this program possible.

Ordering Information

The material is supplied at no cost.  Recipient pays for all shipping charges.

To receive lonafarnib, please fill out an application and material transfer agreement, and submit to

Application and Agreement

Material Transfer Agreement for Non-government Institutions**

** PRF has a policy of no changes to our MTA

Contacts for Questions and Assistance:

Principal Investigator: Leslie B. Gordon, MD, PhD;

Research Study Coordinator: Joan Brazier;

For U.S. Federal Government Institutions or questions, please contact Joan Brazier, Research Study Coordinator, at or 401-863-9628.

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