\u0625\u0646\u0647 \u0645\u0647\u064a\u0645\u0646.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
[\/et_pb_toggle][et_pb_toggle title="4. \u0623\u062d\u062a\u0627\u062c \u0625\u0644\u0649 \u0645\u0642\u0627\u0628\u0644\u0629 \u0628\u0627\u062d\u062b \u0623\u0648 \u062e\u0628\u064a\u0631 \u0622\u062e\u0631 \u0641\u064a \u0645\u062c\u0627\u0644 \u0645\u0631\u0636 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629." open_toggle_background_color="#f7f7f7" closed_toggle_text_color="#ffffff" closed_toggle_background_color="#00b2e2" icon_color="#ffc15e" open_icon_color="#ffc15e" admin_label="4. \u0623\u062d\u062a\u0627\u062c \u0625\u0644\u0649 \u0645\u0642\u0627\u0628\u0644\u0629 \u0628\u0627\u062d\u062b \u0623\u0648 \u062e\u0628\u064a\u0631 \u0622\u062e\u0631 \u0641\u064a \u0645\u062c\u0627\u0644 \u0645\u0631\u0636 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629." _builder_version=\u201d4.16\u2033 title_text_color=\u201d#00b2e2\u2033 background_color=\u201d#ffffff\u201d custom_margin=\u201d10px||10px||true\u201d custom_padding=\u201d|50px||50px||true\u201d animation_style=\u201dslide\u201d animation_direction=\u201dtop\u201d animation_intensity_slide=\u201d25%\u201d link_option_url_new_window=\u201don\u201d z_index_tablet=\u201d500\u2033 border_width_all=\u201d0px\u201d global_colors_info=\u201d{}\u201d]<\/p>\n
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\u0641\u0636\u0644\u0627\u064b \u0639\u0646 \u0630\u0644\u0643\u060c\u00a0\u0627\u0646\u0642\u0631 \u0647\u0646\u0627<\/a>\u00a0\u0644\u0645\u0634\u0627\u0647\u062f\u0629 \u0639\u0631\u0636 \u062a\u0642\u062f\u064a\u0645\u064a \u0645\u062f\u062a\u0647 \u0633\u0627\u0639\u0629 \u0648\u0627\u062d\u062f\u0629 \u0642\u062f\u0645\u0647 \u0645\u0624\u0633\u0633\u0627 PRF \u0627\u0644\u062f\u0643\u062a\u0648\u0631 \u0644\u064a\u0632\u0644\u064a \u062c\u0648\u0631\u062f\u0648\u0646 (\u0627\u0644\u0645\u062f\u064a\u0631 \u0627\u0644\u0637\u0628\u064a \u0644\u0640 PRF) \u0648\u0627\u0644\u062f\u0643\u062a\u0648\u0631 \u0633\u0643\u0648\u062a \u0628\u064a\u0631\u0646\u0632 (\u0631\u0626\u064a\u0633 \u0645\u062c\u0644\u0633 \u0625\u062f\u0627\u0631\u0629 PRF)<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n [\/et_pb_toggle][et_pb_toggle title="5. \u0643\u0645 \u0639\u062f\u062f \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0641\u064a \u0627\u0644\u0639\u0627\u0644\u0645 \u0627\u0644\u0630\u064a\u0646 \u062a\u0645 \u062a\u0634\u062e\u064a\u0635 \u0625\u0635\u0627\u0628\u062a\u0647\u0645 \u0628\u0645\u0631\u0636 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629\u061f" open_toggle_background_color="#f7f7f7" closed_toggle_text_color="#ffffff" closed_toggle_background_color="#00b2e2" icon_color="#ffc15e" open_icon_color="#ffc15e" admin_label="5. \u0643\u0645 \u0639\u062f\u062f \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0641\u064a \u0627\u0644\u0639\u0627\u0644\u0645 \u0627\u0644\u0630\u064a\u0646 \u062a\u0645 \u062a\u0634\u062e\u064a\u0635 \u0625\u0635\u0627\u0628\u062a\u0647\u0645 \u0628\u0645\u0631\u0636 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629\u061f" _builder_version=\u201d4.27.4\u2033 title_text_color=\u201d#00b2e2\u2033 background_color=\u201d#ffffff\u201d custom_margin=\u201d10px||10px||true\u201d custom_padding=\u201d|50px||50px||true\u201d animation_style=\u201dslide\u201d animation_direction=\u201dtop\u201d animation_intensity_slide=\u201d25%\u201d link_option_url_new_window=\u201don\u201d hover_enabled=\u201d0\u2033 z_index_tablet=\u201d500\u2033 border_width_all=\u201d0px\u201d global_colors_info=\u201d{}\u201d sticky_enabled=\u201d0\u2033]<\/p>\n \u0644\u0648 \u0633\u0645\u062d\u062a \u0627\u0646\u0642\u0631 \u0647\u0646\u0627<\/a><\/span> \u0644\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0623\u062d\u062f\u062b "\u062d\u0642\u0627\u0626\u0642 \u0633\u0631\u064a\u0639\u0629" \u0645\u0646 PRF. \u0627\u0633\u062a\u0646\u0627\u062f\u064b\u0627 \u0625\u0644\u0649 \u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0646\u062a\u0634\u0627\u0631\u0646\u0627\u060c \u0646\u0639\u062a\u0642\u062f \u0623\u0646\u0647 \u0644\u0627 \u064a\u0632\u0627\u0644 \u0647\u0646\u0627\u0643 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u062d\u0648\u0644 \u0627\u0644\u0639\u0627\u0644\u0645 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animation_direction=\u201dtop\u201d animation_intensity_slide=\u201d25%\u201d link_option_url_new_window=\u201don\u201d z_index_tablet=\u201d500\u2033 title_text_shadow_horizontal_length_tablet=\u201d0px\u201d title_text_shadow_vertical_length_tablet=\u201d0px\u201d title_text_shadow_blur_strength_tablet=\u201d1px\u201d \u0645\u063a\u0644\u0642_\u0639\u0646\u0648\u0627\u0646_\u0646\u0635_\u0638\u0644_\u0637\u0648\u0644_\u0623\u0641\u0642\u064a_\u0644\u0644\u0637\u0627\u0648\u0644\u0629=\u201d0px\u201d \u0645\u063a\u0644\u0642_\u0639\u0646\u0648\u0627\u0646_\u0646\u0635_\u0638\u0644_\u0637\u0648\u0644_\u0639\u0645\u0648\u062f\u064a_\u0644\u0644\u0637\u0627\u0648\u0644\u0629=\u201d0px\u201d \u0645\u063a\u0644\u0642_\u0639\u0646\u0648\u0627\u0646_\u0646\u0635_\u0638\u0644_\u0637\u0648\u0644_\u0639\u0645\u0648\u062f\u064a_\u0644\u0644\u0637\u0627\u0648\u0644\u0629=\u201d1px\u201d \u062c\u0633\u0645_\u0646\u0635_\u0638\u0644_\u0637\u0648\u0644_\u0623\u0641\u0642\u064a_\u0644\u0644\u0637\u0627\u0648\u0644\u0629=\u201d0px\u201d \u062c\u0633\u0645_\u0646\u0635_\u0638\u0644_\u0637\u0648\u0644_\u0639\u0645\u0648\u062f\u064a_\u0644\u0644\u0637\u0627\u0648\u0644\u0629=\u201d0px\u201d \u062c\u0633\u0645_\u0646\u0635_\u0638\u0644_\u0637\u0648\u0644_\u0639\u0645\u0648\u062f\u064a_\u0644\u0644\u0637\u0627\u0648\u0644\u0629=\u201d0px\u201d \u062c\u0633\u0645_\u0646\u0635_\u0638\u0644_\u0637\u0648\u0644_\u0639\u0645\u0648\u062f\u064a_\u0644\u0644\u0637\u0627\u0648\u0644\u0629=\u201d1px\u201d \u062c\u0633\u0645_\u0631\u0627\u0628\u0637_\u0646\u0635_\u0638\u0644_\u0637\u0648\u0644_\u0623\u0641\u0642\u064a_\u0644\u0644\u0637\u0627\u0648\u0644\u0629=\u201d0px\u201d \u062c\u0633\u0645_\u0631\u0627\u0628\u0637_\u0646\u0635_\u0638\u0644_\u0637\u0648\u0644_\u0639\u0645\u0648\u062f\u064a_\u0644\u0644\u0637\u0627\u0648\u0644\u0629=\u201d0px\u201d \u062c\u0633\u0645_\u0631\u0627\u0628\u0637_\u0646\u0635_\u0638\u0644_\u0637\u0648\u0644_\u0639\u0645\u0648\u062f\u064a_\u0644\u0644\u0637\u0627\u0648\u0644\u0629=\u201d1px\u201d \u062c\u0633\u0645_ul_\u0646\u0635_\u0638\u0644_\u0637\u0648\u0644_\u0623\u0641\u0642\u064a_\u0644\u0644\u0637\u0627\u0648\u0644\u0629=\u201d0px\u201d \u062c\u0633\u0645_ul_\u0646\u0635_\u0638\u0644_\u0637\u0648\u0644_\u0639\u0645\u0648\u062f\u064a_\u0644\u0644\u0637\u0627\u0648\u0644\u0629=\u201d0px\u201d body_ul_text_shadow_blur_strength_tablet=\u201d1px\u201d body_ol_text_shadow_horizontal_length_tablet=\u201d0px\u201d body_ol_text_shadow_vertical_length_tablet=\u201d0px\u201d body_ol_text_shadow_blur_strength_tablet=\u201d1px\u201d body_quote_text_shadow_horizontal_length_tablet=\u201d0px\u201d body_quote_text_shadow_vertical_length_tablet=\u201d0px\u201d body_quote_text_shadow_blur_strength_tablet=\u201d1px\u201d border_width_all=\u201d0px\u201d box_shadow_horizontal_tablet=\u201d0px\u201d box_shadow_vertical_tablet=\u201d0px\u201d box_shadow_blur_tablet=\u201d40px\u201d box_shadow_spread_tablet=\u201d0px\u201d text_shadow_horizontal_length_tablet=\u201d0px\u201d text_shadow_vertical_length_tablet=\u201d0px\u201d text_shadow_blur_strength_tablet=\u201d1px\u201d global_colors_info=\u201d{}\u201d]<\/p>\n \u0645\u0639\u0644\u0648\u0645\u0627\u062a\u0646\u0627 \u0639\u0646 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0633\u0631\u064a\u0629\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u062a\u0641\u0627\u0635\u064a\u0644 \u0639\u0646 \u0645\u0643\u0627\u0646 \u0625\u0642\u0627\u0645\u062a\u0647\u0645. \u0648\u0645\u0639 \u0630\u0644\u0643\u060c\u00a0\u0627\u0646\u0642\u0631 \u0647\u0646\u0627<\/a>\u00a0\u0644\u0639\u0631\u0636 \u062e\u0631\u064a\u0637\u0629 \u0644\u0631\u0624\u064a\u0629 \u0627\u0644\u0645\u0648\u0627\u0642\u0639 \u0627\u0644\u062a\u0642\u0631\u064a\u0628\u064a\u0629 \u0627\u0644\u062a\u064a \u064a\u0642\u064a\u0645\u0648\u0646 \u0641\u064a\u0647\u0627.<\/p>\n<\/div>\n<\/div>\n [\/et_pb_toggle][et_pb_toggle title="7. \u0647\u0644 \u064a\u0634\u0627\u0631\u0643 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0641\u064a \u0627\u0644\u0623\u0646\u0634\u0637\u0629 \u0627\u0644\u0645\u062f\u0631\u0633\u064a\u0629\u060c \u0623\u0645 \u0623\u0646\u0647\u0645 \u0645\u0642\u064a\u062f\u0648\u0646 \u0644\u0623\u0646\u0647\u0645 \u0645\u0635\u0627\u0628\u0648\u0646 \u0628\u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629\u061f" open_toggle_background_color="#f7f7f7" closed_toggle_text_color="#ffffff" closed_toggle_background_color="#00b2e2" icon_color="#ffc15e" open_icon_color="#ffc15e" admin_label="7. \u0647\u0644 \u064a\u0634\u0627\u0631\u0643 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0641\u064a \u0627\u0644\u0623\u0646\u0634\u0637\u0629 \u0627\u0644\u0645\u062f\u0631\u0633\u064a\u0629\u060c \u0623\u0645 \u0623\u0646\u0647\u0645 \u0645\u0642\u064a\u062f\u0648\u0646 \u0644\u0623\u0646\u0647\u0645 \u0645\u0635\u0627\u0628\u0648\u0646 \u0628\u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629\u061f" _builder_version=\u201d4.16\u2033 title_text_color=\u201d#00b2e2\u2033 background_color=\u201d#ffffff\u201d custom_margin=\u201d10px||10px||true\u201d custom_padding=\u201d|50px||50px||true\u201d animation_style=\u201dslide\u201d animation_direction=\u201dtop\u201d animation_intensity_slide=\u201d25%\u201d link_option_url_new_window=\u201don\u201d z_index_tablet=\u201d500\u2033 border_width_all=\u201d0px\u201d global_colors_info=\u201d{}\u201d]<\/p>\n [\/et_pb_toggle][et_pb_toggle title="9. \u0647\u0644 \u064a\u0624\u062b\u0631 \u0627\u0644\u0645\u0631\u0636 \u0639\u0644\u0649 \u0642\u062f\u0631\u0627\u062a\u0647\u0645 \u0627\u0644\u0639\u0642\u0644\u064a\u0629\u061f" open_toggle_background_color="#f7f7f7" closed_toggle_text_color="#ffffff" closed_toggle_background_color="#00b2e2" icon_color="#ffc15e" open_icon_color="#ffc15e" admin_label="9. \u0647\u0644 \u064a\u0624\u062b\u0631 \u0627\u0644\u0645\u0631\u0636 \u0639\u0644\u0649 \u0642\u062f\u0631\u0627\u062a\u0647\u0645 \u0627\u0644\u0639\u0642\u0644\u064a\u0629\u061f" _builder_version=\u201d4.16\u2033 title_text_color=\u201d#00b2e2\u2033 background_color=\u201d#ffffff\u201d custom_margin=\u201d10px||10px||true\u201d custom_padding=\u201d|50px||50px||true\u201d animation_style=\u201dslide\u201d animation_direction=\u201dtop\u201d animation_intensity_slide=\u201d25%\u201d link_option_url_new_window=\u201don\u201d z_index_tablet=\u201d500\u2033 border_width_all=\u201d0px\u201d global_colors_info=\u201d{}\u201d]<\/p>\n \u0639\u0644\u0649 \u0627\u0644\u0625\u0637\u0644\u0627\u0642. \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0627\u0644\u0645\u0635\u0627\u0628\u0648\u0646 \u0628\u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0623\u0630\u0643\u064a\u0627\u0621 \u0648\u0645\u0644\u064a\u0626\u0648\u0646 \u0628\u0627\u0644\u0637\u0627\u0642\u0629 \u062a\u0645\u0627\u0645\u064b\u0627 \u0645\u062b\u0644 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0627\u0644\u0622\u062e\u0631\u064a\u0646 \u0641\u064a \u0633\u0646\u0647\u0645.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n [\/et_pb_toggle][et_pb_toggle title="10. \u0644\u0645\u0627\u0630\u0627 \u064a\u062a\u0642\u062f\u0645 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0627\u0644\u0645\u0635\u0627\u0628\u0648\u0646 \u0628\u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0641\u064a \u0627\u0644\u0639\u0645\u0631 \u0628\u0633\u0631\u0639\u0629 \u0643\u0628\u064a\u0631\u0629 \u0648\u0644\u064a\u0633 \u0641\u064a \u0639\u0642\u0648\u0644\u0647\u0645\u061f" open_toggle_background_color="#f7f7f7" closed_toggle_text_color="#ffffff" closed_toggle_background_color="#00b2e2" icon_color="#ffc15e" open_icon_color="#ffc15e" admin_label="10. \u0644\u0645\u0627\u0630\u0627 \u064a\u062a\u0642\u062f\u0645 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0627\u0644\u0645\u0635\u0627\u0628\u0648\u0646 \u0628\u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0641\u064a \u0627\u0644\u0639\u0645\u0631 \u0628\u0633\u0631\u0639\u0629 \u0643\u0628\u064a\u0631\u0629 \u0648\u0644\u064a\u0633 \u0641\u064a \u0639\u0642\u0648\u0644\u0647\u0645\u061f" _builder_version=\u201d4.16\u2033 title_text_color=\u201d#00b2e2\u2033 background_color=\u201d#ffffff\u201d custom_margin=\u201d10px||10px||true\u201d custom_padding=\u201d|50px||50px||true\u201d animation_style=\u201dslide\u201d animation_direction=\u201dtop\u201d animation_intensity_slide=\u201d25%\u201d link_option_url_new_window=\u201don\u201d z_index_tablet=\u201d500\u2033 border_width_all=\u201d0px\u201d global_colors_info=\u201d{}\u201d]<\/p>\n \u0644\u0627 \u064a\u062a\u0645 \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0639\u0646 LMNA \u0628\u0648\u0627\u0633\u0637\u0629 \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u062e\u060c \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u0641\u0625\u0646 \u0637\u0641\u0631\u0629 \u0627\u0644\u062c\u064a\u0646 \u0644\u0627 \u062a\u0624\u062b\u0631 \u0639\u0644\u0649 \u0627\u0644\u0645\u062e.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n [\/et_pb_toggle][et_pb_toggle title="11. \u0645\u0627 \u0647\u064a \u0627\u0644\u0642\u0636\u0627\u064a\u0627 \u0627\u0644\u062a\u064a \u062a\u0639\u062a\u0642\u062f \u0623\u0646\u0647\u0627 \u0627\u0644\u0623\u0643\u062b\u0631 \u0623\u0647\u0645\u064a\u0629 \u0641\u064a \u0631\u0639\u0627\u064a\u0629 \u0645\u0631\u064a\u0636 \u0645\u0635\u0627\u0628 \u0628\u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629\u061f" open_toggle_background_color="#f7f7f7" closed_toggle_text_color="#ffffff" closed_toggle_background_color="#00b2e2" icon_color="#ffc15e" open_icon_color="#ffc15e" admin_label="11. \u0645\u0627 \u0647\u064a \u0627\u0644\u0642\u0636\u0627\u064a\u0627 \u0627\u0644\u062a\u064a \u062a\u0639\u062a\u0642\u062f \u0623\u0646\u0647\u0627 \u0627\u0644\u0623\u0643\u062b\u0631 \u0623\u0647\u0645\u064a\u0629 \u0641\u064a \u0631\u0639\u0627\u064a\u0629 \u0645\u0631\u064a\u0636 \u0645\u0635\u0627\u0628 \u0628\u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629\u061f" _builder_version=\u201d4.16\u2033 title_text_color=\u201d#00b2e2\u2033 background_color=\u201d#ffffff\u201d custom_margin=\u201d10px||10px||true\u201d custom_padding=\u201d|50px||50px||true\u201d animation_style=\u201dslide\u201d animation_direction=\u201dtop\u201d animation_intensity_slide=\u201d25%\u201d link_option_url_new_window=\u201don\u201d z_index_tablet=\u201d500\u2033 border_width_all=\u201d0px\u201d global_colors_info=\u201d{}\u201d]<\/p>\n \u0625\u0646 \u0623\u0647\u0645 \u0645\u0627 \u0641\u064a \u0627\u0644\u0623\u0645\u0631 \u0647\u0648 \u0623\u0646 \u0646\u062a\u0630\u0643\u0631 \u0623\u0646 \u0643\u0644 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u064a\u062a\u0645\u062a\u0639\u0648\u0646 \u0628\u0630\u0643\u0627\u0621 \u0648\u0634\u062e\u0635\u064a\u0629 \u062a\u062a\u0646\u0627\u0633\u0628 \u0645\u0639 \u0623\u0639\u0645\u0627\u0631\u0647\u0645. \u0641\u0627\u0644\u0637\u0641\u0644 \u0627\u0644\u0645\u0635\u0627\u0628 \u0628\u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0627\u0644\u0630\u064a \u064a\u0628\u0644\u063a \u0645\u0646 \u0627\u0644\u0639\u0645\u0631 \u062b\u0645\u0627\u0646\u064a \u0633\u0646\u0648\u0627\u062a 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\u0627\u0644\u0642\u0644\u0628\u060c \u0648\u0644\u064a\u0633 \u0639\u0642\u0648\u0644\u0647\u0645. \u0644\u0630\u0627 \u0641\u0647\u0645 \u064a\u062d\u062a\u0627\u062c\u0648\u0646 \u0625\u0644\u0649 \u0623\u0646 \u062a\u0639\u0627\u0645\u0644\u0647\u0645 \u0645\u062f\u0627\u0631\u0633\u0647\u0645 \u0648\u0645\u062c\u062a\u0645\u0639\u0627\u062a\u0647\u0645 \u0648\u0623\u0635\u062f\u0642\u0627\u0626\u0647\u0645 \u0645\u062b\u0644 \u0623\u064a \u0637\u0641\u0644 \u0622\u062e\u0631 (\u0645\u0639 \u0628\u0639\u0636 \u0627\u0644\u062a\u0639\u062f\u064a\u0644\u0627\u062a \u0627\u0644\u0637\u0641\u064a\u0641\u0629 \u0641\u064a \u0627\u0644\u062d\u062c\u0645).\u00a0\u0641\u064a \u0646\u0647\u0627\u064a\u0629 \u0627\u0644\u0645\u0637\u0627\u0641\u060c \u0641\u0625\u0646 \u0645\u0631\u0636 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0647\u0648 \u0645\u062c\u0631\u062f \u062c\u0632\u0621 \u0635\u063a\u064a\u0631 \u0645\u0646 \u0634\u062e\u0635\u064a\u062a\u0647\u0645!<\/em><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n [\/et_pb_toggle][et_pb_toggle title="12. \u0647\u0644 \u0647\u0646\u0627\u0643 \u0623\u064a \u0639\u0644\u0627\u062c\u0627\u062a \u0645\u062a\u0627\u062d\u0629\u061f" open_toggle_background_color="#f7f7f7" closed_toggle_text_color="#ffffff" closed_toggle_background_color="#00b2e2" icon_color="#ffc15e" open_icon_color="#ffc15e" admin_label="12. \u0647\u0644 \u0647\u0646\u0627\u0643 \u0623\u064a \u0639\u0644\u0627\u062c\u0627\u062a \u0645\u062a\u0627\u062d\u0629\u061f" _builder_version=\u201d4.17.6\u2033 title_text_color=\u201d#00b2e2\u2033 background_color=\u201d#ffffff\u201d vertical_offset_tablet=\u201d0\u2033 horizontal_offset_tablet=\u201d0\u2033 custom_margin=\u201d10px||10px||true\u201d custom_padding=\u201d|50px||50px||true\u201d animation_style=\u201dslide\u201d animation_direction=\u201dtop\u201d animation_intensity_slide=\u201d25%\u201d link_option_url_new_window=\u201don\u201d z_index_tablet=\u201d500\u2033 title_text_shadow_horizontal_length_tablet=\u201d0px\u201d title_text_shadow_vertical_length_tablet=\u201d0px\u201d title_text_shadow_blur_strength_tablet=\u201d1px\u201d \u0645\u063a\u0644\u0642_\u0639\u0646\u0648\u0627\u0646_\u0646\u0635_\u0638\u0644_\u0637\u0648\u0644_\u0623\u0641\u0642\u064a_\u0644\u0644\u0637\u0627\u0648\u0644\u0629=\u201d0px\u201d \u0645\u063a\u0644\u0642_\u0639\u0646\u0648\u0627\u0646_\u0646\u0635_\u0638\u0644_\u0637\u0648\u0644_\u0639\u0645\u0648\u062f\u064a_\u0644\u0644\u0637\u0627\u0648\u0644\u0629=\u201d0px\u201d \u0645\u063a\u0644\u0642_\u0639\u0646\u0648\u0627\u0646_\u0646\u0635_\u0638\u0644_\u0637\u0648\u0644_\u0639\u0645\u0648\u062f\u064a_\u0644\u0644\u0637\u0627\u0648\u0644\u0629=\u201d1px\u201d \u062c\u0633\u0645_\u0646\u0635_\u0638\u0644_\u0637\u0648\u0644_\u0623\u0641\u0642\u064a_\u0644\u0644\u0637\u0627\u0648\u0644\u0629=\u201d0px\u201d \u062c\u0633\u0645_\u0646\u0635_\u0638\u0644_\u0637\u0648\u0644_\u0639\u0645\u0648\u062f\u064a_\u0644\u0644\u0637\u0627\u0648\u0644\u0629=\u201d0px\u201d \u062c\u0633\u0645_\u0646\u0635_\u0638\u0644_\u0637\u0648\u0644_\u0639\u0645\u0648\u062f\u064a_\u0644\u0644\u0637\u0627\u0648\u0644\u0629=\u201d0px\u201d \u062c\u0633\u0645_\u0646\u0635_\u0638\u0644_\u0637\u0648\u0644_\u0639\u0645\u0648\u062f\u064a_\u0644\u0644\u0637\u0627\u0648\u0644\u0629=\u201d1px\u201d \u062c\u0633\u0645_\u0631\u0627\u0628\u0637_\u0646\u0635_\u0638\u0644_\u0637\u0648\u0644_\u0623\u0641\u0642\u064a_\u0644\u0644\u0637\u0627\u0648\u0644\u0629=\u201d0px\u201d \u062c\u0633\u0645_\u0631\u0627\u0628\u0637_\u0646\u0635_\u0638\u0644_\u0637\u0648\u0644_\u0639\u0645\u0648\u062f\u064a_\u0644\u0644\u0637\u0627\u0648\u0644\u0629=\u201d0px\u201d \u062c\u0633\u0645_\u0631\u0627\u0628\u0637_\u0646\u0635_\u0638\u0644_\u0637\u0648\u0644_\u0639\u0645\u0648\u062f\u064a_\u0644\u0644\u0637\u0627\u0648\u0644\u0629=\u201d1px\u201d \u062c\u0633\u0645_ul_\u0646\u0635_\u0638\u0644_\u0637\u0648\u0644_\u0623\u0641\u0642\u064a_\u0644\u0644\u0637\u0627\u0648\u0644\u0629=\u201d0px\u201d \u062c\u0633\u0645_ul_\u0646\u0635_\u0638\u0644_\u0637\u0648\u0644_\u0639\u0645\u0648\u062f\u064a_\u0644\u0644\u0637\u0627\u0648\u0644\u0629=\u201d0px\u201d body_ul_text_shadow_blur_strength_tablet=\u201d1px\u201d body_ol_text_shadow_horizontal_length_tablet=\u201d0px\u201d body_ol_text_shadow_vertical_length_tablet=\u201d0px\u201d body_ol_text_shadow_blur_strength_tablet=\u201d1px\u201d body_quote_text_shadow_horizontal_length_tablet=\u201d0px\u201d body_quote_text_shadow_vertical_length_tablet=\u201d0px\u201d body_quote_text_shadow_blur_strength_tablet=\u201d1px\u201d border_width_all=\u201d0px\u201d box_shadow_horizontal_tablet=\u201d0px\u201d box_shadow_vertical_tablet=\u201d0px\u201d box_shadow_blur_tablet=\u201d40px\u201d box_shadow_spread_tablet=\u201d0px\u201d text_shadow_horizontal_length_tablet=\u201d0px\u201d text_shadow_vertical_length_tablet=\u201d0px\u201d text_shadow_blur_strength_tablet=\u201d1px\u201d global_colors_info=\u201d{}\u201d]<\/p>\n \u0646\u0639\u0645. \u0641\u064a \u0646\u0648\u0641\u0645\u0628\u0631 2020\u060c \u062d\u0642\u0642\u062a PRF \u062c\u0632\u0621\u064b\u0627 \u0645\u0647\u0645\u064b\u0627 \u0645\u0646 \u0645\u0647\u0645\u062a\u0646\u0627: \u0623\u0648\u0644 \u0639\u0644\u0627\u062c \u0639\u0644\u0649 \u0627\u0644\u0625\u0637\u0644\u0627\u0642 \u0644\u0645\u0631\u0636 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629\u060c \u0648\u0647\u0648 lonafarnib (\u0627\u0644\u0627\u0633\u0645 \u0627\u0644\u062a\u062c\u0627\u0631\u064a "Zokinvy") \u062a\u0645 \u0645\u0646\u062d\u0647 \u0645\u0648\u0627\u0641\u0642\u0629 \u0645\u0646 \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 (US FDA)<\/a>\u0628\u0641\u0636\u0644 \u0647\u0630\u0627 \u0627\u0644\u0625\u0646\u062c\u0627\u0632\u060c \u0627\u0646\u0636\u0645\u062a \u0628\u0631\u0648\u062c\u064a\u0631\u064a\u0627 \u0627\u0644\u0622\u0646 \u0625\u0644\u0649 \u0623\u0642\u0644 \u0645\u0646\u00a05% \u0645\u0646 \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0646\u0627\u062f\u0631\u0629 \u0627\u0644\u062a\u064a \u0644\u0647\u0627 \u0639\u0644\u0627\u062c \u0645\u0639\u062a\u0645\u062f \u0645\u0646 \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621.*<\/strong><\/p>\n \u0641\u064a \u0639\u0627\u0645 2019\u060c \u0646\u0634\u0631\u062a \u0645\u0624\u0633\u0633\u0629 \u0623\u0628\u062d\u0627\u062b \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0646\u0633\u062e\u062a\u0646\u0627 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u0645\u0646 \u062f\u0644\u064a\u0644 \u0627\u0644\u0628\u0631\u0648\u062c\u064a\u0631\u064a\u0627<\/a>\u060c \u0644\u0644\u0639\u0627\u0626\u0644\u0627\u062a \u0648\u0627\u0644\u0623\u0637\u0628\u0627\u0621 \u0648\u0645\u0639\u0644\u0645\u064a \u0627\u0644\u0645\u062f\u0627\u0631\u0633 \u0648\u063a\u064a\u0631\u0647\u0645 \u0645\u0645\u0646 \u064a\u0639\u062a\u0646\u0648\u0646 \u0628\u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0648\u0627\u0644\u0634\u0628\u0627\u0628 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629. \u0645\u0639 \u0627\u0644\u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u0645\u0648\u0627\u062f\u060c \u064a\u0648\u0636\u062d \u0647\u0630\u0627 \u0627\u0644\u0625\u0635\u062f\u0627\u0631 \u0627\u0644\u0645\u062d\u062f\u062b \u0627\u0644\u0645\u0643\u0648\u0646 \u0645\u0646 131 \u0635\u0641\u062d\u0629 \u0645\u062f\u0649 \u0627\u0644\u062a\u0642\u062f\u0645 \u0627\u0644\u0630\u064a \u0623\u062d\u0631\u0632\u0646\u0627\u0647 \u0641\u064a \u0641\u0647\u0645\u0646\u0627 \u0627\u0644\u0633\u0631\u064a\u0631\u064a \u0644\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0645\u0646\u0630 \u0646\u0634\u0631 \u0627\u0644\u0625\u0635\u062f\u0627\u0631 \u0627\u0644\u0623\u0648\u0644 \u0641\u064a \u0639\u0627\u0645 2010. \u062a\u062a\u0636\u0645\u0646 \u0627\u0644\u0625\u0636\u0627\u0641\u0627\u062a \u0623\u0642\u0633\u0627\u0645\u064b\u0627 \u0639\u0646 \u0639\u0644\u0645 \u0627\u0644\u0648\u0631\u0627\u062b\u0629 \u0648\u0627\u0644\u0627\u0633\u062a\u0634\u0627\u0631\u0629 \u0627\u0644\u0648\u0631\u0627\u062b\u064a\u0629 \u0648\u0639\u0644\u0627\u062c \u0644\u0648\u0646\u0627\u0641\u0627\u0631\u0646\u064a\u0628 \u0648\u062a\u0648\u0635\u064a\u0627\u062a \u062c\u062f\u064a\u062f\u0629 \u0628\u0634\u0623\u0646 \u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0642\u0644\u0628 \u0648\u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629 \u0644\u0645\u0642\u062f\u0645\u064a \u0627\u0644\u0631\u0639\u0627\u064a\u0629.<\/p>\n \u0644\u0627 \u064a\u0648\u062c\u062f \u0639\u0644\u0627\u062c \u062d\u062a\u0649 \u0627\u0644\u0622\u0646\u060c \u0648\u0644\u0643\u0646\u0646\u0627 \u0646\u0639\u0644\u0645 \u0623\u0646 \u0627\u0644\u0631\u0639\u0627\u064a\u0629 \u0627\u0644\u064a\u0648\u0645\u064a\u0629 \u062a\u062d\u062f\u062b \u0641\u0631\u0642\u064b\u0627 \u0643\u0628\u064a\u0631\u064b\u0627 \u0641\u064a \u062c\u0648\u062f\u0629 \u062d\u064a\u0627\u062a\u0647\u0645. \u062a\u0639\u062f \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u063a\u0630\u0627\u0626\u064a\u0629 \u0648\u0627\u0644\u062c\u0633\u062f\u064a\u0629 \u0648\u0627\u0644\u0645\u0647\u0646\u064a\u0629 \u0627\u0644\u0645\u0646\u0627\u0633\u0628\u0629\u060c \u0625\u0644\u0649 \u062c\u0627\u0646\u0628 \u0627\u0644\u0631\u0639\u0627\u064a\u0629 \u0627\u0644\u0648\u0642\u0627\u0626\u064a\u0629 \u0644\u0644\u0642\u0644\u0628 \u0648\u063a\u064a\u0631\u0647\u0627 \u0645\u0646 \u0627\u0644\u0631\u0639\u0627\u064a\u0629\u060c \u0636\u0631\u0648\u0631\u064a\u0629. \u0627\u0644\u062f\u0644\u064a\u0644 \u0645\u062a\u0627\u062d \u0628\u0627\u0644\u0644\u063a\u0627\u062a \u0627\u0644\u0625\u0646\u062c\u0644\u064a\u0632\u064a\u0629 \u0648\u0627\u0644\u064a\u0627\u0628\u0627\u0646\u064a\u0629 \u0648\u0627\u0644\u0625\u0633\u0628\u0627\u0646\u064a\u0629.<\/p>\n *300 \u0645\u0631\u0636 \u0646\u0627\u062f\u0631 \u0644\u0647\u0627 \u0639\u0644\u0627\u062c \u0645\u0639\u062a\u0645\u062f \u0645\u0646 \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 (https:\/\/www.rarediseases.info.nih.gov\/diseases\/FDS-orphan-drugs)\/7,000<\/a>\u00a0\u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0646\u0627\u062f\u0631\u0629 \u0627\u0644\u062a\u064a \u064a\u064f\u0639\u0631\u0641 \u0623\u0633\u0627\u0633\u0647\u0627 \u0627\u0644\u062c\u0632\u064a\u0626\u064a (www.OMIM.org<\/a>) =4.2%<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n [\/et_pb_toggle][et_pb_toggle title="13. \u0647\u0644 \u0627\u0642\u062a\u0631\u0628 \u0623\u064a \u0639\u0644\u0645\u0627\u0621 \u0645\u0646 \u0625\u064a\u062c\u0627\u062f \u0639\u0644\u0627\u062c\u061f" open_toggle_background_color="#f7f7f7" closed_toggle_text_color="#ffffff" closed_toggle_background_color="#00b2e2" icon_color="#ffc15e" open_icon_color="#ffc15e" admin_label="13. \u0647\u0644 \u0627\u0642\u062a\u0631\u0628 \u0623\u064a \u0639\u0644\u0645\u0627\u0621 \u0645\u0646 \u0625\u064a\u062c\u0627\u062f \u0639\u0644\u0627\u062c\u061f" _builder_version=\u201d4.16\u2033 title_text_color=\u201d#00b2e2\u2033 background_color=\u201d#ffffff\u201d custom_margin=\u201d10px||10px||true\u201d custom_padding=\u201d|50px||50px||true\u201d animation_style=\u201dslide\u201d animation_direction=\u201dtop\u201d animation_intensity_slide=\u201d25%\u201d link_option_url_new_window=\u201don\u201d z_index_tablet=\u201d500\u2033 border_width_all=\u201d0px\u201d global_colors_info=\u201d{}\u201d]<\/p>\n \u0633\u0627\u0639\u062f\u062a \u0645\u0624\u0633\u0633\u0629 \u0623\u0628\u062d\u0627\u062b \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0641\u064a \u0627\u0643\u062a\u0634\u0627\u0641 \u0627\u0644\u062c\u064a\u0646 \u0627\u0644\u0645\u0633\u0628\u0628 \u0644\u0645\u0631\u0636 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629\u060c \u0648\u0647\u064a \u0627\u0644\u0622\u0646 \u062a\u0634\u0627\u0631\u0643 \u0641\u064a\u00a0\u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0644\u0623\u062f\u0648\u064a\u0629\u060c<\/a>\u00a0\u0627\u062e\u062a\u0628\u0627\u0631 \u0623\u062f\u0648\u064a\u0629 \u062a\u0638\u0647\u0631 \u0648\u0639\u062f\u064b\u0627 \u0643\u0628\u064a\u0631\u064b\u0627 \u0641\u064a \u0639\u0644\u0627\u062c \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0645\u0631\u0636 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0628\u0634\u0643\u0644 \u0641\u0639\u0627\u0644. \u0644\u0642\u062f \u062d\u0642\u0642\u0646\u0627 \u062a\u0642\u062f\u0645\u064b\u0627 \u0647\u0627\u0626\u0644\u0627\u064b\u060c \u0644\u0643\u0646 \u0644\u0627 \u0623\u062d\u062f \u064a\u0633\u062a\u0637\u064a\u0639 \u0627\u0644\u062a\u0646\u0628\u0624 \u0628\u0627\u0644\u0645\u062f\u0629 \u0627\u0644\u062a\u064a \u0642\u062f \u064a\u0633\u062a\u063a\u0631\u0642\u0647\u0627 \u0630\u0644\u0643.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n [\/et_pb_toggle][et_pb_toggle title="14. \u0645\u0627 \u0627\u0644\u0623\u0628\u062d\u0627\u062b \u0627\u0644\u062a\u064a \u062a\u0642\u0648\u0645 \u0628\u0647\u0627 \u062d\u0627\u0644\u064a\u064b\u0627 \u062d\u0648\u0644 \u0647\u0630\u0627 \u0627\u0644\u0645\u0631\u0636\u061f" open_toggle_background_color="#f7f7f7" closed_toggle_text_color="#ffffff" closed_toggle_background_color="#00b2e2" icon_color="#ffc15e" open_icon_color="#ffc15e" admin_label="14. \u0645\u0627 \u0627\u0644\u0623\u0628\u062d\u0627\u062b \u0627\u0644\u062a\u064a \u062a\u0642\u0648\u0645 \u0628\u0647\u0627 \u062d\u0627\u0644\u064a\u064b\u0627 \u062d\u0648\u0644 \u0647\u0630\u0627 \u0627\u0644\u0645\u0631\u0636\u061f" _builder_version=\u201d4.16\u2033 title_text_color=\u201d#00b2e2\u2033 background_color=\u201d#ffffff\u201d custom_margin=\u201d10px||10px||true\u201d custom_padding=\u201d|50px||50px||true\u201d animation_style=\u201dslide\u201d animation_direction=\u201dtop\u201d animation_intensity_slide=\u201d25%\u201d link_option_url_new_window=\u201don\u201d z_index_tablet=\u201d500\u2033 border_width_all=\u201d0px\u201d global_colors_info=\u201d{}\u201d]<\/p>\n \u0627\u0646\u0638\u0631 \u0645\u0648\u0642\u0639\u0646\u0627\u00a0\u0627\u0644\u0645\u0646\u062d \u0627\u0644\u062a\u064a \u0642\u0645\u0646\u0627 \u0628\u062a\u0645\u0648\u064a\u0644\u0647\u0627\u00a0<\/a>\u0642\u0633\u0645 \u0644\u0648\u0635\u0641 \u0627\u0644\u0645\u0634\u0627\u0631\u064a\u0639\u060c \u0644\u062f\u064a\u0646\u0627\u00a0\u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629<\/a>\u00a0\u0627\u0644\u062a\u062d\u062f\u064a\u062b\u0627\u062a \u0648\u00a0PRF \u0641\u064a \u0627\u0644\u0623\u062e\u0628\u0627\u0631<\/a>\u00a0\u0644\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0623\u062d\u062f\u062b \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0623\u0628\u062d\u0627\u062b.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n [\/et_pb_toggle][et_pb_toggle title="15. \u0623\u0648\u062f \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0625\u0630\u0646 \u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 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custom_margin=\u201d10px||10px||true\u201d custom_padding=\u201d|50px||50px||true\u201d animation_style=\u201dslide\u201d animation_direction=\u201dtop\u201d animation_intensity_slide=\u201d25%\u201d link_option_url_new_window=\u201don\u201d z_index_tablet=\u201d500\u2033 border_width_all=\u201d0px\u201d global_colors_info=\u201d{}\u201d]<\/p>\n \u0644\u0627 \u0628\u0623\u0633 \u0645\u0646 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0623\u064a \u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0646\u0635\u064a\u0629 \u062a\u0645 \u062c\u0645\u0639\u0647\u0627 \u0645\u0646 \u0645\u0648\u0642\u0639\u0646\u0627 \u0627\u0644\u0625\u0644\u0643\u062a\u0631\u0648\u0646\u064a \u0644\u0645\u0634\u0631\u0648\u0639\u0643. \u0648\u0645\u0639 \u0630\u0644\u0643\u060c \u0646\u0641\u0636\u0644 \u0623\u0644\u0627 \u062a\u0633\u062a\u062e\u062f\u0645 \u0635\u0648\u0631 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0645\u0646 \u0645\u0648\u0642\u0639\u0646\u0627 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\u0627\u0644\u0622\u0646\u061f" open_toggle_background_color="#f7f7f7" closed_toggle_text_color="#ffffff" closed_toggle_background_color="#00b2e2" icon_color="#ffc15e" open_icon_color="#ffc15e" admin_label="17. \u0645\u0627 \u0627\u0644\u0630\u064a \u062a\u0648\u062f \u0623\u0646 \u064a\u0639\u0631\u0641\u0647 \u0627\u0644\u0646\u0627\u0633 \u0639\u0646 \u0645\u0631\u0636 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0627\u0644\u0622\u0646\u061f" _builder_version=\u201d4.16\u2033 title_text_color=\u201d#00b2e2\u2033 background_color=\u201d#ffffff\u201d custom_margin=\u201d10px||10px||true\u201d custom_padding=\u201d|50px||50px||true\u201d animation_style=\u201dslide\u201d animation_direction=\u201dtop\u201d animation_intensity_slide=\u201d25%\u201d link_option_url_new_window=\u201don\u201d z_index_tablet=\u201d500\u2033 border_width_all=\u201d0px\u201d global_colors_info=\u201d{}\u201d]<\/p>\n \u0641\u064a \u062d\u064a\u0646 \u0623\u0646 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animation_direction=\u201dtop\u201d animation_intensity_slide=\u201d25%\u201d link_option_url_new_window=\u201don\u201d z_index_tablet=\u201d500\u2033 border_width_all=\u201d0px\u201d global_colors_info=\u201d{}\u201d]<\/p>\n \u064a\u0627 \u0644\u0647 \u0645\u0646 \u0623\u0645\u0631 \u0631\u0627\u0626\u0639! \u062a\u062e\u062a\u0644\u0641 \u0627\u0644\u0625\u062c\u0627\u0628\u0629 \u0639\u0644\u0649 \u0647\u0630\u0627 \u0627\u0644\u0633\u0624\u0627\u0644 \u0628\u0627\u062e\u062a\u0644\u0627\u0641 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062a\u0639\u0644\u064a\u0645\u064a\u0629 \u0627\u0644\u062a\u064a \u0648\u0635\u0644\u062a \u0625\u0644\u064a\u0647\u0627. \u0646\u0642\u062a\u0631\u062d \u0639\u0644\u064a\u0643 \u0627\u0633\u062a\u0634\u0627\u0631\u0629 \u0645\u0633\u062a\u0634\u0627\u0631 \u0627\u0644\u062a\u0648\u062c\u064a\u0647 \u0623\u0648 \u0627\u0644\u062a\u0648\u062c\u064a\u0647 \u0627\u0644\u0645\u0647\u0646\u064a \u0641\u064a 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custom_padding=\u201d|50px||50px||true\u201d animation_style=\u201dslide\u201d animation_direction=\u201dtop\u201d animation_intensity_slide=\u201d25%\u201d link_option_url_new_window=\u201don\u201d z_index_tablet=\u201d500\u2033 border_width_all=\u201d0px\u201d global_colors_info=\u201d{}\u201d]<\/p>\n \u0644\u0623\u0633\u0628\u0627\u0628 \u062a\u062a\u0639\u0644\u0642 \u0628\u0627\u0644\u0633\u0631\u064a\u0629 \u0643\u0645\u0627 \u0647\u0648 \u0645\u0648\u0636\u062d \u0641\u064a \u0627\u0644\u0625\u062c\u0627\u0628\u0629 \u0623\u0639\u0644\u0627\u0647\u060c \u0644\u0627 \u064a\u0645\u0643\u0646\u0646\u0627 \u0623\u0646 \u0646\u0648\u0635\u0644\u0643 \u0628\u0634\u062e\u0635 \u0645\u0627 \u0644\u0644\u062a\u062d\u062f\u062b \u0645\u0639\u0647 \u062d\u0648\u0644 \u0627\u0644\u0639\u064a\u0634 \u0645\u0639 \u0645\u0631\u0636 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629. \u064a\u0631\u062c\u0649 \u0627\u0644\u0631\u062c\u0648\u0639 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title="22. \u0645\u0627\u0630\u0627 \u064a\u0633\u062a\u0637\u064a\u0639 \u0627\u0644\u0646\u0627\u0633 \u0623\u0646 \u064a\u0641\u0639\u0644\u0648\u0627 \u0644\u0644\u0645\u0633\u0627\u0639\u062f\u0629\u061f \u0645\u0646 \u0623\u064a\u0646 \u062a\u062d\u0635\u0644 \u0639\u0644\u0649 \u0645\u0639\u0638\u0645 \u062a\u0645\u0648\u064a\u0644\u0643\u061f" open_toggle_background_color="#f7f7f7" closed_toggle_text_color="#ffffff" closed_toggle_background_color="#00b2e2" icon_color="#ffc15e" open_icon_color="#ffc15e" admin_label="22. \u0645\u0627\u0630\u0627 \u064a\u0633\u062a\u0637\u064a\u0639 \u0627\u0644\u0646\u0627\u0633 \u0623\u0646 \u064a\u0641\u0639\u0644\u0648\u0627 \u0644\u0644\u0645\u0633\u0627\u0639\u062f\u0629\u061f \u0645\u0646 \u0623\u064a\u0646 \u062a\u062d\u0635\u0644 \u0639\u0644\u0649 \u0645\u0639\u0638\u0645 \u062a\u0645\u0648\u064a\u0644\u0643\u061f" _builder_version=\u201d4.16\u2033 title_text_color=\u201d#00b2e2\u2033 background_color=\u201d#ffffff\u201d custom_margin=\u201d10px||10px||true\u201d custom_padding=\u201d|50px||50px||true\u201d animation_style=\u201dslide\u201d animation_direction=\u201dtop\u201d animation_intensity_slide=\u201d25%\u201d link_option_url_new_window=\u201don\u201d z_index_tablet=\u201d500\u2033 border_width_all=\u201d0px\u201d global_colors_info=\u201d{}\u201d]<\/p>\n \u062a\u0645\u0643\u0646\u062a \u0645\u0624\u0633\u0633\u0629 \u0623\u0628\u062d\u0627\u062b \u0645\u0631\u0636 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0645\u0646 \u0625\u0646\u062c\u0627\u0632 \u0642\u062f\u0631 \u0647\u0627\u0626\u0644 \u0645\u0646 \u0627\u0644\u0639\u0645\u0644 \u0628\u0645\u0628\u0644\u063a \u0635\u063a\u064a\u0631 \u0645\u0646 \u0627\u0644\u0645\u0627\u0644. \u0644\u064a\u0633 \u0644\u062f\u064a\u0646\u0627 \u0635\u0646\u062f\u0648\u0642 \u0648\u0642\u0641\u060c \u0648\u0646\u0639\u062a\u0645\u062f \u0639\u0644\u0649 \u0627\u0644\u062f\u0639\u0645 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PRF.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n [\/et_pb_toggle][et_pb_toggle title="23. \u0647\u0644 \u064a\u0648\u062c\u062f \u0641\u0631\u0639 \u0628\u0627\u0644\u0642\u0631\u0628 \u0645\u0646 \u062d\u064a\u062b \u0623\u0639\u064a\u0634 \u064a\u0645\u0643\u0646\u0646\u064a \u0627\u0644\u0627\u062a\u0635\u0627\u0644 \u0628\u0647\u061f" open_toggle_background_color="#f7f7f7" closed_toggle_text_color="#ffffff" closed_toggle_background_color="#00b2e2" icon_color="#ffc15e" open_icon_color="#ffc15e" admin_label="23. \u0647\u0644 \u064a\u0648\u062c\u062f \u0641\u0631\u0639 \u0628\u0627\u0644\u0642\u0631\u0628 \u0645\u0646 \u062d\u064a\u062b \u0623\u0639\u064a\u0634 \u064a\u0645\u0643\u0646\u0646\u064a \u0627\u0644\u0627\u062a\u0635\u0627\u0644 \u0628\u0647\u061f" _builder_version=\u201d4.16\u2033 title_text_color=\u201d#00b2e2\u2033 background_color=\u201d#ffffff\u201d custom_margin=\u201d10px||10px||true\u201d 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![](\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2017\/02\/lindsay-Jul08-crpd.jpg\")
\r\n\r\n\u201cMy fifteen-year-old daughter just wrote a research paper on this topic, and she was so moved by the precious children, that she asked to donate her own money to this cause. It's great that you have things on the web that can give these children exposure and a voice to those of us who may never personally meet one!\u201d Lisa Hagen\r\n\r\nDo you have questions you need answered for a school report? Do you want to learn more about the children? Are you interested in knowing more about Progeria and the work PRF does? We've got the answers for you right here!\r\n\r\nWe love the fact that awareness about Progeria is spreading throughout the world and that you want to learn more, thank you! But we are so very busy at the office doing all the things that are needed to advance our mission of finding treatments and a cure that\u00a0we can no longer individually answer the many requests we receive from around the world.\u00a0Instead, we have prepared this Question and Answer sheet to help provide you with the information you're looking for, taking the most common questions we are asked and answering them below. We hope this helps you get top grades on your school report, or just helps you understand more about Progeria and The Progeria Research Foundation so that you can help spread the word about the wonderful work we are doing for these special children.\r\n\r\n[\/vc_column_text][vc_separator][vc_column_text]1. I'm doing a school report on Progeria, can you help me get more information on this subject?<\/strong>\r\n\r\nIn addition to finding the cure and effective treatments for Hutchinson-Gilford Progeria Syndrome, part of our mission is to promote public awareness of this disease. By doing a report on Progeria, you are helping us accomplish that part of our mission. Thanks so much, we're glad to help you!\r\n\r\nBefore you read any further, please visit our Frequently Asked Questions<\/a> section to learn more about Progeria. Other sections you may find helpful are The Connection to Other Diseases<\/a> , and The Science Behind Progeria<\/a>. The information on those pages is not repeated here.\r\n\r\nIf you are looking for more advanced, scientific information, please visit https:\/\/www.pubmed.gov\/<\/a> which provides abstracts for many scientific publications on Progeria.\r\n\r\nFor key scientific publications that have helped advance Progeria research since the 2003 Progeria gene discovery, visit our What\u2019s News in Progeria Research<\/a> section.\r\n\r\nAlso, you can access information on the NORD (National Organization of Rare Diseases) web site. Go to https:\/\/www.rarediseases.org\/<\/a>, and click on their Rare Diseases Database, then type \u201cHutchinson Gilford Progeria\u201d in the search box, and a page on Progeria will appear. If you want a detailed report, there may be a cost.\r\n\r\nFor books on Progeria, here are a few publications that you may find useful:\r\n\r\nKeith Moore, father of a child who died of Progeria, wrote Old at Age 3,<\/a> <\/strong>the story of Zachary Moore,<\/em> to share the story of his son\u2019s extraordinary life.\r\n\r\nDr. Leslie Gordon, PRF\u2019s Medical Director, wrote a chapter on Progeria for the World Book Online Reference Center<\/em>\u00a0![\"\"](\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2017\/04\/iconPDF.gif\")
World Book Progeria<\/a>\u00a0and the print edition of the 2008 World Book Encyclopedia\r\n\r\nDr. Gordon, W. Ted Brown and Frank Rothman wrote a chapter entitled LMNA and the Hutchinson-Gilford Progeria Syndrome and Associated Laminopathies for the book Inborn Errors of Development: The molecular basis of clinical disorders of morphogenesis<\/em> (2007, 2nd ed.) 139: 1219-1229.\r\n\r\nIf you give us your address, we can send you a ![](\"https:\/\/www.progeriaresearch.org\/assets\/images\/iconPDF.gif\")
brochure<\/a> <\/strong>and our latest newsletter<\/a>\u00a0<\/strong>to include with your report.\r\n\r\n
\r\n\r\n<\/a>2. I heard that the Progeria gene had been discovered, where can I find out more about this?<\/strong>\r\n\r\nOn April 16, 2003, it was announced that the gene for Progeria had been discovered, and PRF played a major role in that discovery! Go to Progeria Gene Discovered<\/a> for more information. Also, here are some cites to scientific articles on the gene mutation:\r\n\r\n\"Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford Progeria Syndrome\", Vol. 423, May 15, 2003, Nature.\r\n\r\n\"Mutation causes early-aging syndrome\", Vol. 163, p.260, April 26, 2003, Science News.\r\n\r\n\"Cause of Progeria's Premature Aging Found; expected to Provide Insight into Normal Aging Process\", Vol. 289, no. 19, pp. 2481-2482, May 21, 2003, JAMA.\r\n\r\n
\r\n\r\n<\/a>3. Is Progeria a dominant or recessive disease?<\/strong>\r\n\r\nIt is Dominant.\r\n\r\n
\r\n\r\n<\/a>4. I need to interview a researcher or other expert in the field of Progeria.<\/strong>\r\n\r\nUnfortunately, due to the large number of requests and our small staff, we cannot provide interviews and we do not provide the contact information of others. However, our Medical Director Dr. Leslie Gordon has helped create this Q and A and all other information on Progeria that appears on this site, so we hope that is sufficient to satisfy the interview requirement for your report. Dr. Gordon is a leading expert on Progeria; she is the director of all of PRF\u2019s research-related programs including our International Progeria Registry and Diagnostics Testing program, has authored dozens of scientific publications that appear in peer-reviewed, well-respected journals, has been one of the leaders in all of the Boston clinical drug trials, and has examined more children with Progeria than anyone in the world.\r\n\r\nIn addition, click here<\/a> to view a 1-hour presentation by PRF co-founders Dr. Leslie Gordon (PRF\u2019s Medical Director) and Dr. Scott Berns (PRF\u2019s Chairman of the Board)\r\n\r\n
\r\n\r\n<\/a>5. How many children in the world are diagnosed with Progeria?<\/strong>\r\n\r\nYou can\u00a0 Click Here<\/a>\u00a0for the most recent numbers and countries, however, we believe that there are more children who have this condition, but have not yet been diagnosed. Visit FindtheOther150.org<\/a> for ways you can help, and hear from parents and experts through podcasts.\r\n\r\n
\r\n\r\n<\/a>6. Where do the children live?<\/strong>\r\n\r\nOur information about children with Progeria is confidential, including details about where they live. However, Click here<\/a> to view a map to see the approximate locations they reside in.\r\n\r\n
\r\n\r\n<\/a>7. Do the children participate in school activities, or are they limited because they have Progeria?<\/strong>\r\n\r\nChildren with Progeria are able to participate in all the same educational programs and sports activities as other children. With the exception of having Progeria, these children are just like their peers - Most have no special capacities or limitations other than those that their shorter stature and perhaps stiff joints cause for some activities. More details on school and general aspects of living with Progeria can be found in chapters 16 and 17 of The Progeria Handbook<\/a>.\r\n\r\n
\r\n\r\n<\/a>8. What is it like for a child to live with Progeria?<\/strong>\r\n\r\nJohn Tackett, our first youth Ambassador, was interviewed about what it's like to live with Progeria and other questions. You can find this information at Interview with John Tacket<\/a>.\r\n\r\nWe also suggest you check out a TEDx MidAtlantic talk by Sam Berns entitled, \u201cMy Philosophy for a Happy Life\u201d on our TedX Talks page.<\/a> This wildly popular talk has inspired millions around the world to look at life in a more positive way.\r\n\r\n
\r\n\r\n<\/a>9. Does the disease affect their mental abilities?<\/strong>\r\n\r\nNot at all. Children with Progeria are intelligent and full of energy just like other kids their age.\r\n\r\n
\r\n\r\n<\/a>10. Why do children with Progeria age in body so rapidly and not in mind?<\/strong>\r\n\r\nLMNA is not expressed by the brain cells, so the gene mutation does not affect the brain.\r\n\r\n
\r\n\r\n<\/a>11. What issues do you think are most important in the care of a patient with Progeria?<\/strong>\r\n\r\nMost of all, it is important to remember that all children with Progeria have age appropriate intellect and personality. An eight-year-old with Progeria will think and act just like every other eight-year-old. Children with Progeria are smart and funny and full of life. It's the bodies of these children that are laden with the genetic predisposition toward conditions of aging and heart disease, not their minds. So they need their schools and communities and their friends to treat them just like any other child (with a few minor adjustments for size). After all, Progeria is just a small part of who they are!<\/em>\r\n\r\n
\r\n\r\n<\/a>12. Are there any treatments available?<\/strong>\r\n\r\nYes. In April 2010, The Progeria Research Foundation published The Progeria Handbook<\/a>,\u00a0for families and doctors. From basic health facts to daily care recommendations to extensive treatment guidelines, this 100-page handbook helps answer many questions for children with Progeria throughout the world. We don't have a cure yet, but we do know that daily care makes a huge difference in their quality of life. Proper nutritional, physical, and occupational therapies, along with preventative cardiac and other care are essential. The handbook is also available in other languages.\r\n\r\nIn addition, history was made in September 2012 when the first-ever drug treatment was discovered.<\/a> Every child in the clinical trial involving Lonafarnib, a farnesyl transferase inhibitor, showed improvement in one or more of four ways: gaining additional weight, better hearing, improved bone structure and\/or, most importantly, increased flexibility of blood vessels. Results of the study, which was funded and coordinated by The Progeria Research Foundation, were published September 24, 2012 in Proceedings of the National Academy of Sciences.<\/strong><\/em><\/a> \u00a0Further studies published\u00a0<\/a>in\u00a0Circulation<\/i><\/b>\u00a0<\/i>in May 2014<\/a>\u00a0and April 2018 in The Journal of The American Medical Association<\/em><\/a> reveal that lonafarnib also increases the children\u2019s estimated lifespan. \u00a0We now know that drugs can improve the disease, as we continue to search for even more effective compounds and ultimately, the cure.\r\n\r\n
\r\n\r\n<\/a>13. Are any scientists close to finding a cure?<\/strong>\r\n\r\nThe Progeria Research Foundation helped in the discovery of the gene that causes Progeria, and is now involved in clinical drug trials,<\/a> testing drugs that show great promise to effectively treat children with Progeria. We have made tremendous progress, but no one can predict how long that will take.\r\n\r\n