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\u0642\u0628\u0644 \u0627\u0644\u0645\u062a\u062e\u0635\u0635\u064a\u0646 \u0641\u064a \u0627\u0644\u0631\u0639\u0627\u064a\u0629 \u0627\u0644\u0635\u062d\u064a\u0629 \u0648\u0627\u0644\u0628\u0627\u062d\u062b\u064a\u0646 \u0627\u0644\u0637\u0628\u064a\u064a\u0646 \u0648\u0623\u0633\u0631 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0645\u0631\u0636 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629.<\/p>\n<h4><strong>\u0623\u0647\u062f\u0627\u0641 \u0642\u0627\u0639\u062f\u0629 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a<\/strong><\/h4>\n<ul>\n<li>\u0644\u0648\u0635\u0641 \u0628\u0627\u0644\u062a\u0641\u0635\u064a\u0644 \u0645\u0627 \u0647\u064a \u0627\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0627\u062a \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0646\u0627\u062c\u062d\u0629\u060c \u0648\u0645\u0627 \u0647\u064a \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u062a\u064a \u0641\u0634\u0644\u062a \u0641\u064a \u0627\u0644\u062a\u0639\u0627\u0645\u0644 \u0645\u0639 \u0627\u0644\u0645\u0634\u0627\u0643\u0644 \u0627\u0644\u0637\u0628\u064a\u0629 \u0627\u0644\u062a\u064a \u064a\u0648\u0627\u062c\u0647\u0647\u0627 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0627\u0644\u0645\u0635\u0627\u0628\u0648\u0646 \u0628\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629. \u0642\u062f \u064a\u0633\u0627\u0639\u062f \u0647\u0630\u0627 \u0627\u0644\u0623\u0633\u0631 \u0648\u0623\u0637\u0628\u0627\u0626\u0647\u0645 \u0639\u0644\u0649 \u0641\u0647\u0645 \u0623\u0641\u0636\u0644 \u0627\u0644\u0633\u0628\u0644 \u0644\u0631\u0639\u0627\u064a\u0629 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629.<\/li>\n<li>\u062a\u0648\u0641\u064a\u0631 \u062a\u0648\u0635\u064a\u0627\u062a \u0627\u0644\u0631\u0639\u0627\u064a\u0629 \u0627\u0644\u0635\u062d\u064a\u0629 \u0644\u0644\u0623\u0633\u0631 \u0628\u0644\u063a\u0629 \u063a\u064a\u0631 \u0637\u0628\u064a\u0629 \u062d\u0648\u0644 \u0627\u0644\u0642\u0636\u0627\u064a\u0627 \u0627\u0644\u0645\u0647\u0645\u0629 \u0644\u062c\u0648\u062f\u0629 \u062d\u064a\u0627\u0629 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0640 HGPS.<\/li>\n<li>\u062a\u0634\u0643\u0644 \u0642\u0627\u0639\u062f\u0629 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0645\u0648\u0631\u062f\u064b\u0627 \u0644\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0631\u0624\u0649 \u062c\u062f\u064a\u062f\u0629 \u062d\u0648\u0644 \u0637\u0628\u064a\u0639\u0629 HGPS \u0648\u0637\u0628\u064a\u0639\u0629 \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0623\u062e\u0631\u0649 \u0645\u062b\u0644 \u062a\u0635\u0644\u0628 \u0627\u0644\u0634\u0631\u0627\u064a\u064a\u0646\u060c \u0645\u0645\u0627 \u0633\u064a\u0633\u0627\u0639\u062f \u0628\u062f\u0648\u0631\u0647 \u0639\u0644\u0649 \u062a\u062d\u0641\u064a\u0632 \u062a\u0642\u062f\u0645 \u0645\u0634\u0627\u0631\u064a\u0639 \u0628\u062d\u062b\u064a\u0629 \u062c\u062f\u064a\u062f\u0629.<\/li>\n<\/ul>\n<h4><strong>\u0645\u0648\u0627\u0641\u0642\u0627\u062a \u0645\u062c\u0644\u0633 \u0627\u0644\u0645\u0631\u0627\u062c\u0639\u0629 \u0627\u0644\u0645\u0624\u0633\u0633\u064a\u0629:<\/strong><\/h4>\n<p>\u062a\u0645\u062a \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u0649 \u0642\u0627\u0639\u062f\u0629 \u0628\u064a\u0627\u0646\u0627\u062a PRF \u0627\u0644\u0637\u0628\u064a\u0629 \u0648\u0627\u0644\u0628\u062d\u062b\u064a\u0629 \u0645\u0646 \u0642\u0628\u0644 \u0645\u062c\u0644\u0633 \u0627\u0644\u0645\u0631\u0627\u062c\u0639\u0629 \u0627\u0644\u0645\u0624\u0633\u0633\u064a (IRB) \u0645\u0646 \u0642\u0628\u0644 \u0645\u0633\u062a\u0634\u0641\u0649 \u0631\u0648\u062f \u0622\u064a\u0644\u0627\u0646\u062f \u0648\u0644\u062c\u0627\u0646 \u062c\u0627\u0645\u0639\u0629 \u0628\u0631\u0627\u0648\u0646 \u0644\u062d\u0645\u0627\u064a\u0629 \u0627\u0644\u0623\u0634\u062e\u0627\u0635 \u0627\u0644\u062e\u0627\u0636\u0639\u064a\u0646 \u0644\u0644\u0627\u062e\u062a\u0628\u0627\u0631. \u0645\u0633\u062a\u0634\u0641\u0649 \u0631\u0648\u062f \u0622\u064a\u0644\u0627\u0646\u062f Federal Wide Assurance FWA00001230\u060c \u062f\u0631\u0627\u0633\u0629 CMTT# 0152-01\u060c \u062c\u0627\u0645\u0639\u0629 \u0628\u0631\u0627\u0648\u0646 Federal Wide Assurance FWA 00004460\u060c \u062f\u0631\u0627\u0633\u0629 CMTT# 0211991243<\/p>\n<h4 style=\"font-weight: 400;\"><strong>\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u0648\u0627\u062f \u0641\u064a \u0627\u0644\u0645\u0646\u0634\u0648\u0631\u0627\u062a:<\/strong><\/h4>\n<p style=\"font-weight: 400;\">\u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u062c\u0645\u064a\u0639 \u0627\u0644\u0645\u0646\u0634\u0648\u0631\u0627\u062a \u0627\u0644\u0646\u0627\u062a\u062c\u0629 \u0639\u0646 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u0645\u062f\u0629 \u0645\u0646 \u0642\u0627\u0639\u062f\u0629 \u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0623\u0628\u062d\u0627\u062b \u0627\u0644\u0637\u0628\u064a\u0629 \u0644\u0645\u0624\u0633\u0633\u0629 \u0628\u0631\u0648\u062c\u064a\u0631\u064a\u0627 \u0644\u0644\u0623\u0628\u062d\u0627\u062b\u060c \u064a\u062a\u0639\u064a\u0646 \u0639\u0644\u0649 \u0627\u0644\u0628\u0627\u062d\u062b\u064a\u0646 \u062a\u0636\u0645\u064a\u0646 \u0627\u0644\u0627\u0642\u062a\u0628\u0627\u0633 \u0627\u0644\u062a\u0627\u0644\u064a \u0636\u0645\u0646 \u0642\u0633\u0645 \u0627\u0644\u0645\u0648\u0627\u062f \u0648\u0627\u0644\u0637\u0631\u0642 (\u0648\u0644\u064a\u0633 \u0641\u0642\u0637 \u0627\u0644\u0625\u0642\u0631\u0627\u0631\u0627\u062a). \u0642\u062f \u064a\u062e\u062a\u0644\u0641 \u0647\u0630\u0627 \u0627\u0644\u0635\u064a\u0627\u063a\u0629 \u0642\u0644\u064a\u0644\u0627\u064b\u060c \u0627\u0639\u062a\u0645\u0627\u062f\u064b\u0627 \u0639\u0644\u0649 \u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0627\u0644\u0645\u0642\u062f\u0645\u0629 \u0644\u0644\u0628\u062d\u062b.<\/p>\n<p style=\"font-weight: 400;\">&quot;\u062a\u0645 \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0645\u062c\u0647\u0648\u0644\u0629 \u0627\u0644\u0647\u0648\u064a\u0629 \u0645\u0646 \u0642\u0627\u0639\u062f\u0629 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0637\u0628\u064a\u0629 \u0648\u0627\u0644\u0628\u062d\u062b\u064a\u0629 \u0644\u0645\u0624\u0633\u0633\u0629 \u0623\u0628\u062d\u0627\u062b \u0645\u0631\u0636 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 (PRF)&quot;<a href=\"https:\/\/www.progeriaresearch.org\/ar\/\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/www.progeriaresearch.org&amp;source=gmail&amp;ust=1656539975208000&amp;usg=AOvVaw2-Ugfzc0IoTq-jMG-qMW0F\">www.progeriaresearch.org<\/a>&quot; ).&quot;<\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner]\u0627\u0633\u062a\u062e\u062f\u0627\u0645_\u0645\u0631\u0628\u0639_\u0645\u062e\u0635\u0635=\u201don\u201d\u0645\u0631\u0628\u0639_\u0645\u062e\u0635\u0635=\u201d1\u2033 _builder_version=\u201d4.16\u2033\u0644\u0648\u0646_\u0627\u0644\u062e\u0644\u0641\u064a\u0629=\u201d#29327a\u201d\u0627\u0644\u062d\u0634\u0648_\u0627\u0644\u0645\u062e\u0635\u0635=\u201d40px|35px|35.2344px|35px|false|true\u201d\u0646\u0645\u0637_\u0627\u0644\u0631\u0633\u0648\u0645_\u0627\u0644\u0645\u062a\u062d\u0631\u0643\u0629=\u201d\u0627\u0644\u0634\u0631\u064a\u062d\u0629\u201d\u0627\u062a\u062c\u0627\u0647_\u0627\u0644\u0631\u0633\u0648\u0645_\u0627\u0644\u0645\u062a\u062d\u0631\u0643\u0629=\u201d\u0627\u0644\u064a\u0645\u064a\u0646\u201d\u0643\u062b\u0627\u0641\u0629_\u0627\u0644\u0631\u0633\u0648\u0645_\u0627\u0644\u0645\u062a\u062d\u0631\u0643\u0629=\u201d25%\u201d\u0639\u0631\u0636_\u0627\u0644\u062d\u062f\u0648\u062f_\u0627\u0644\u0633\u0641\u0644\u0649=\u201d10px\u201d\u0644\u0648\u0646_\u0627\u0644\u062d\u062f\u0648\u062f_\u0627\u0644\u0633\u0641\u0644\u0649=\u201d#8fd2ed\u201d\u0645\u063a\u0644\u0642=\u201d\u0625\u064a\u0642\u0627\u0641\u201dglobal_colors_info=\u201d{}\u201d][et_pb_column_inner\u062d\u0641\u0638_\u0646\u0648\u0639_\u0627\u0644\u062a\u062e\u0635\u0635=\u201d3_4\u2033 _builder_version=\u201d4.16\u2033 custom_padding=\u201d|||\u201d global_colors_info=\u201d{}\u201d custom_padding__hover=\u201d|||\u201d][et_pb_text admin_label=\u201d\u0627\u0644\u0645\u0646\u0634\u0648\u0631\u0627\u062a \u0627\u0644\u0635\u0627\u062f\u0631\u0629 \u0639\u0646 \u0642\u0627\u0639\u062f\u0629 \u0628\u064a\u0627\u0646\u0627\u062a \u0645\u0624\u0633\u0633\u0629 \u0623\u0628\u062d\u0627\u062b \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0627\u0644\u0637\u0628\u064a\u0629 \u0648\u0627\u0644\u0628\u062d\u062b\u064a\u0629\u201d _builder_version=\u201d4.16\u2033 header_text_align=\u201dcenter\u201d header_text_color=\u201d#ffffff\u201d background_layout=\u201ddark\u201d animation_style=\u201dfade\u201d header_font_size_tablet=\u201d\u201d header_font_size_phone=\u201d30px\u201d header_font_size_last_edited=\u201don|desktop\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n<h2 style=\"text-align: center;\"><strong>\u0627\u0644\u0645\u0646\u0634\u0648\u0631\u0627\u062a \u0627\u0644\u0635\u0627\u062f\u0631\u0629 \u0639\u0646 \u0642\u0627\u0639\u062f\u0629 \u0628\u064a\u0627\u0646\u0627\u062a \u0645\u0624\u0633\u0633\u0629 \u0623\u0628\u062d\u0627\u062b \u0645\u0631\u0636 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0627\u0644\u0637\u0628\u064a\u0629 \u0648\u0627\u0644\u0628\u062d\u062b\u064a\u0629<\/strong><\/h2>\n<p>\u00a0<\/p>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner column_structure=&quot;1_2,1_2&quot; custom_padding_last_edited=&quot;on|phone&quot; padding_left_right_link_1=&quot;false&quot; padding_left_right_link_2=&quot;false&quot; _builder_version=&quot;4.16&quot; custom_padding=&quot;|35px|0|0px|false|false&quot; custom_padding_tablet=&quot;|35px||35px||true&quot; custom_padding_phone=&quot;&quot; animation_direction=&quot;top&quot; border_width_bottom=&quot;10px&quot; border_color_bottom=&quot;#8fd2ed&quot; global_colors_info=&quot;{}&quot;][et_pb_column_inner \u0627\u0644\u0646\u0648\u0639 = &quot;1_2&quot; saved_specialty_column_type = &quot;3_4&quot; _builder_version = &quot;4.16&quot; custom_padding = &quot;|20 \u0628\u0643\u0633\u0644 ||&quot; global_colors_info = &quot;{}&quot; custom_padding__hover = &quot;|||&quot;][et_pb_text _builder_version = &quot;4.16&quot; global_colors_info = &quot;{}&quot;]<\/p>\n<p>\u0633\u0627\u0647\u0645\u062a \u0642\u0627\u0639\u062f\u0629 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0637\u0628\u064a\u0629 \u0648\u0627\u0644\u0628\u062d\u062b\u064a\u0629 \u0644\u0645\u0624\u0633\u0633\u0629 \u0623\u0628\u062d\u0627\u062b \u0645\u0631\u0636 \u0628\u0631\u0648\u062c\u064a\u0631\u064a\u0627 \u0641\u064a \u0627\u0644\u0645\u0646\u0634\u0648\u0631\u0627\u062a \u0627\u0644\u0637\u0628\u064a\u0629 \u0627\u0644\u062a\u0627\u0644\u064a\u0629:<\/p>\n<p><strong>\u062f\u0644\u064a\u0644 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\u0623\u0628\u062d\u0627\u062b \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629. \u062c\u0645\u064a\u0639 \u0627\u0644\u062d\u0642\u0648\u0642 \u0645\u062d\u0641\u0648\u0638\u0629.<\/p>\n<p>\u00a0\u062a\u062a\u0648\u0641\u0631 \u0627\u0644\u0637\u0628\u0639\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0645\u0646 \u0627\u0644\u062f\u0644\u064a\u0644 \u0628\u0627\u0644\u0644\u063a\u062a\u064a\u0646 \u0627\u0644\u0625\u0633\u0628\u0627\u0646\u064a\u0629 \u0648\u0627\u0644\u0628\u0631\u062a\u063a\u0627\u0644\u064a\u0629. \u0648\u0633\u064a\u062a\u0645 \u0646\u0634\u0631 \u062a\u0631\u062c\u0645\u0627\u062a \u0627\u0644\u0637\u0628\u0639\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u0645\u0646 \u0627\u0644\u062f\u0644\u064a\u0644 \u0628\u0627\u0644\u0644\u063a\u062a\u064a\u0646 \u0627\u0644\u0625\u0633\u0628\u0627\u0646\u064a\u0629 \u0648\u0627\u0644\u0628\u0631\u062a\u063a\u0627\u0644\u064a\u0629 \u0639\u0646\u062f \u062a\u0648\u0641\u0631\u0647\u0627.<\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][\/et_pb_column_inner][et_pb_column_inner type=&quot;1_2&quot; saved_specialty_column_type=&quot;3_4&quot; _builder_version=&quot;4.16&quot; custom_padding=&quot;|||15px&quot; global_colors_info=&quot;{}&quot; custom_padding__hover=&quot;|||&quot;][et_pb_button button_url=&quot;https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/01\/Handbook-2018-PDF-One-File-v3-1.pdf&quot; url_new_window=&quot;on&quot; button_text=&quot;\u0627\u0644\u0637\u0628\u0639\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 - \u0627\u0644\u0625\u0646\u062c\u0644\u064a\u0632\u064a\u0629&quot; button_alignment=&quot;center&quot; admin_label=&quot;\u0627\u0644\u0637\u0628\u0639\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 - \u0627\u0644\u0625\u0646\u062c\u0644\u064a\u0632\u064a\u0629&quot; _builder_version=\u201d4.16\u2033 background_layout=\u201ddark\u201d custom_margin=\u201d||20px\u201d animation_style=\u201dslide\u201d animation_direction=\u201dright\u201d animation_intensity_slide=\u201d25%\u201d z_index_tablet=\u201d500\u2033 custom_css_main_element=\u201dwidth: 70%;\u201d global_colors_info=\u201d{}\u201d]<br \/>\n[\/et_pb_button][et_pb_button button_url=&#8221;https:\/\/www.progeriaresearch.org\/assets\/files\/pdf\/PRF%20Handbook%20Spanish.pdf&#8221; url_new_window=&#8221;on&#8221; button_text=&#8221;1st Edition &#8211; Spanish&#8221; button_alignment=&#8221;center&#8221; admin_label=&#8221;1st Edition &#8211; Spanish&#8221; _builder_version=&#8221;4.16&#8243; background_layout=&#8221;dark&#8221; custom_margin=&#8221;||20px&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;right&#8221; animation_intensity_slide=&#8221;25%&#8221; z_index_tablet=&#8221;500&#8243; custom_css_main_element=&#8221;width: 70%;&#8221; global_colors_info=&#8221;{}&#8221;]<br \/>\n[\/et_pb_button][et_pb_button button_url=&quot;https:\/\/www.progeriaresearch.org\/assets\/files\/pdf\/Handbook\u2014Portuguese.pdf&quot; button_text=&quot;\u0627\u0644\u0637\u0628\u0639\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 - \u0627\u0644\u0628\u0631\u062a\u063a\u0627\u0644\u064a\u0629&quot; button_alignment=&quot;\u0627\u0644\u0645\u0631\u0643\u0632&quot; admin_label=&quot;\u0627\u0644\u0637\u0628\u0639\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 - \u0627\u0644\u0628\u0631\u062a\u063a\u0627\u0644\u064a\u0629&quot; _builder_version=&quot;4.16&quot; background_layout=&quot;dark&quot; custom_margin=&quot;||20px&quot; animation_style=&quot;slide&quot; animation_direction=&quot;right&quot; animation_intensity_slide=&quot;25%&quot; z_index_tablet=&quot;500&quot; custom_css_main_element=&quot;\u0627\u0644\u0639\u0631\u0636: 70%\u061b&quot; global_colors_info=&quot;{}&quot;]<br \/>\n[\/et_pb_button][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner]custom_padding_last_edited=&quot;\u0639\u0644\u0649|\u0627\u0644\u0647\u0627\u062a\u0641&quot; _builder_version=&quot;4.16&quot; custom_padding=&quot;0|35px|0|0px|false|false&quot; custom_padding_tablet=&quot;|35px||35px||true&quot; custom_padding_phone=&quot;&quot; animation_direction=&quot;\u0623\u0639\u0644\u0649&quot; global_colors_info=&quot;{}&quot;][et_pb_column_inner saved_specialty_column_type=&quot;3_4&quot; _builder_version=&quot;4.16&quot; custom_padding=&quot;|||&quot; global_colors_info=\u201d{}\u201d custom_padding__hover=\u201d|||\u201d][et_pb_text admin_label=\u201d\u0645\u0642\u0627\u0644\u0627\u062a \u0627\u0644\u0645\u062c\u0644\u0627\u062a\u201d _builder_version=\u201d4.17.6\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201drepeat\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n<h4><strong>\u0627\u0644\u0645\u0642\u0627\u0644\u0627\u062a \u0627\u0644\u0635\u062d\u0641\u064a\u0629<\/strong><\/h4>\n<p class=\"m_5556619090296294739MsoNoSpacing\"><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35752705\/\" target=\"_blank\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/pubmed.ncbi.nlm.nih.gov\/35752705\/&amp;source=gmail&amp;ust=1658414740427000&amp;usg=AOvVaw3JN2-5dxsoBxFs9Lk6gXDY\" rel=\"noopener\">\u0644\u0627 \u062a\u0646\u062a\u0634\u0631 \u0639\u0645\u0644\u064a\u0629 \u062a\u0643\u0648\u064a\u0646 \u0627\u0644\u062f\u0645 \u0627\u0644\u0627\u0633\u062a\u0646\u0633\u0627\u062e\u064a \u0641\u064a \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0647\u062a\u0634\u064a\u0646\u0633\u0648\u0646 \u062c\u064a\u0644\u0641\u0648\u0631\u062f<\/a><\/strong><br \/><span><u><\/u><u><\/u><\/span><span>\u062f\u064a\u064a\u0632-\u062f\u064a\u064a\u0632 \u0625\u0645\u060c \u0623\u0645\u0648\u0631\u0648\u0633-\u0628\u064a\u0631\u064a\u0632 \u0625\u0645\u060c \u062f\u064a \u0644\u0627 \u0628\u0627\u0631\u064a\u0631\u0627 \u062c\u064a\u060c \u0648\u0622\u062e\u0631\u0648\u0646. [\u062a\u0645 \u0646\u0634\u0631\u0647 \u0639\u0628\u0631 \u0627\u0644\u0625\u0646\u062a\u0631\u0646\u062a \u0642\u0628\u0644 \u0637\u0628\u0639\u0647 \u0641\u064a 25 \u064a\u0648\u0646\u064a\u0648 2022]. \u0639\u0644\u0645 \u0627\u0644\u0623\u0631\u0636. 2022;10.1007\/s11357-022-00607-<wbr \/>2. \u062f\u0648\u0649:10.1007\/s11357-022-00607-2<\/span><\/p>\n<p><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29710166\/?from_term=Gordon+LB+Association+of+&amp;from_pos=1\" target=\"_blank\" rel=\"noopener noreferrer\">\u0627\u0644\u0639\u0644\u0627\u0642\u0629 \u0628\u064a\u0646 \u0639\u0644\u0627\u062c \u0644\u0648\u0646\u0627\u0641\u0627\u0631\u0646\u064a\u0628 \u0648\u0639\u062f\u0645 \u0627\u0644\u0639\u0644\u0627\u062c \u0648\u0645\u0639\u062f\u0644 \u0627\u0644\u0648\u0641\u064a\u0627\u062a \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0647\u062a\u0634\u064a\u0646\u0633\u0648\u0646 \u062c\u064a\u0644\u0641\u0648\u0631\u062f \u0628\u0631\u0648\u062c\u064a\u0631\u064a\u0627.<\/a><\/strong><br \/>\u062c\u0648\u0631\u062f\u0648\u0646 \u0644\u0628\u060c \u0634\u0627\u0628\u064a\u0644 \u062d\u060c \u0645\u0627\u0633\u0627\u0631\u0648 \u064a\u060c \u062f\u0627\u062c\u0648\u0633\u062a\u064a\u0646\u0648 \u0631\u0628 \u0631\u064a\u0627\u0644\u060c \u0628\u0631\u0627\u0632\u064a\u064a\u0631 \u064a\u060c \u0643\u0627\u0645\u0628\u0644 SE\u060c \u0643\u0644\u0627\u064a\u0646\u0645\u0627\u0646 \u0644\u064a\u060c \u0643\u064a\u0631\u0627\u0646 MW.\u062c\u0648\u0631\u062f\u0648\u0646 \u0644\u0628\u060c \u0648\u0622\u062e\u0631\u0648\u0646. \u062c\u0627\u0645\u0627. 2018 \u0623\u0628\u0631\u064a\u0644 24;319(16):1687-1695. \u062f\u0648\u0649: 10.1001\/jama.2018.3264.<\/p>\n<p><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30450527\/?from_term=lessel+d&amp;from_page=4&amp;from_pos=4\" target=\"_blank\" rel=\"noopener noreferrer\">\u064a\u0624\u0643\u062f \u062a\u062d\u0644\u064a\u0644 \u062d\u0627\u0644\u0627\u062a LMNA \u0627\u0644\u0633\u0644\u0628\u064a\u0629 \u0644\u062f\u0649 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0645\u0631\u0636 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0639\u0644\u0649 \u0648\u062c\u0648\u062f \u0637\u0641\u0631\u0627\u062a POLR3A \u062b\u0646\u0627\u0626\u064a\u0629 \u0627\u0644\u0623\u0644\u064a\u0644\u0627\u062a \u0641\u064a \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u062a\u0634\u0628\u0647 \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0641\u064a\u062f\u0645\u0627\u0646-\u0631\u0627\u0648\u062a\u0646\u0633\u062a\u0631\u0627\u0648\u062e \u0648\u064a\u0648\u0633\u0639 \u0627\u0644\u0637\u064a\u0641 \u0627\u0644\u0638\u0627\u0647\u0631\u064a \u0644\u0637\u0641\u0631\u0627\u062a PYCR1.<\/a><\/strong><br \/>Lessel D\u060c Ozel AB\u060c Campbell SE\u060c Saadi A\u060c Arlt MF\u060c McSweeney KM\u060c Plaiasu V\u060c Szakszon K\u060c Sz\u0151ll\u0151s A\u060c Rusu C\u060c Rojas AJ\u060c Lopez-Valdez J\u060c Thiele H\u060c N\u00fcrnberg P\u060c Nickerson DA\u060c Bamshad MJ\u060c \u0644\u064a \u062c\u064a \u0632\u062f\u060c \u0643\u0648\u0628\u064a\u0634 \u0633\u064a\u060c \u062c\u0644\u0648\u0641\u0631 \u062a\u064a \u062f\u0628\u0644\u064a\u0648\u060c \u062c\u0648\u0631\u062f\u0648\u0646 \u0625\u0644 \u0628\u064a \u0644\u064a\u0633\u064a\u0644 \u062f\u060c \u0648\u0622\u062e\u0631\u0648\u0646. \u0647\u0648\u0645 \u062c\u064a\u0646\u064a\u062a. 2018 \u062f\u064a\u0633\u0645\u0628\u0631;137(11-12):921-939. \u062f\u0648\u0649: 10.1007\/s00439-018-1957-1. Epub 2018 \u0646\u0648\u0641\u0645\u0628\u0631 19.Hum Genet. 2018. \u0628\u0645\u064a\u062f: 30450527<\/p>\n<p><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29581305\/?from_term=dubose+a&amp;from_pos=1\" target=\"_blank\" rel=\"noopener noreferrer\">\u064a\u0646\u0642\u0630 \u0625\u064a\u0641\u064a\u0631\u0648\u0644\u064a\u0645\u0648\u0633 \u0639\u064a\u0648\u0628\u064b\u0627 \u062e\u0644\u0648\u064a\u0629 \u0645\u062a\u0639\u062f\u062f\u0629 \u0641\u064a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0644\u064a\u0641\u064a\u0629 \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0635\u0641\u064a\u062d\u0629. <\/a><\/strong><br \/>DuBose AJ\u060c Lichtenstein ST\u060c Petrash NM\u060c Erdos MR\u060c Gordon LB\u060c Collins FS. DuBose AJ\u060c \u0648\u0622\u062e\u0631\u0648\u0646. Proc Natl Acad Sci US A. 2018 Apr 17\u061b115(16):4206-4211. doi: 10.1073\/pnas.1802811115. Epub 2018 Mar 26. Proc Natl Acad Sci US A. 2018. PMID: 29581305<\/p>\n<p><strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28756152\" target=\"_blank\" rel=\"noopener noreferrer\">\u0627\u0644\u0633\u0645\u0627\u062a \u0627\u0644\u0639\u064a\u0646\u064a\u0629 \u0644\u0645\u0631\u0636 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629.<br \/><\/a><\/strong>\u0645\u0627\u0646\u062a\u0627\u062c\u0648\u0633 IS\u060c \u0643\u0644\u0627\u064a\u0646\u0645\u0627\u0646 ME\u060c \u0643\u064a\u0631\u0627\u0646 MW\u060c \u062c\u0648\u0631\u062f\u0648\u0646 LB.<br \/>Am J Ophthalmol. 2017 Jul 27. pii: S0002-9394(17)30317-3. doi: 10.1016\/j.ajo.2017.07.020. [\u0646\u0634\u0631 \u0625\u0644\u0643\u062a\u0631\u0648\u0646\u064a \u0642\u0628\u0644 \u0627\u0644\u0637\u0628\u0627\u0639\u0629]<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27920058\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>\u0637\u0641\u0631\u0629 \u062c\u0633\u062f\u064a\u0629 \u062c\u062f\u064a\u062f\u0629 \u062a\u062d\u0642\u0642 \u0625\u0646\u0642\u0627\u0630\u064b\u0627 \u062c\u0632\u0626\u064a\u064b\u0627 \u0644\u0637\u0641\u0644 \u0645\u0635\u0627\u0628 \u0628\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0647\u062a\u0634\u064a\u0646\u0633\u0648\u0646 \u062c\u064a\u0644\u0641\u0648\u0631\u062f.<\/strong><br \/><\/a>\u0628\u0627\u0631 DZ\u060c \u0623\u0631\u0644\u062a MF\u060c \u0628\u0631\u0627\u0632\u064a\u064a\u0631 JF\u060c \u0646\u0648\u0631\u064a\u0633 WE\u060c \u0643\u0627\u0645\u0628\u0644 SE\u060c \u062a\u0634\u064a\u0646\u0632 P\u060c \u0644\u0627\u0631\u064a\u0648 D\u060c \u062c\u0627\u0643\u0633\u0648\u0646 SP\u060c \u0643\u0648\u0644\u064a\u0646\u0632 FS\u060c \u063a\u0644\u0648\u0641\u0631 TW\u060c \u062c\u0648\u0631\u062f\u0648\u0646 LB.<br \/>\u062c\u064a \u0645\u064a\u062f \u062c\u064a\u0646\u064a\u062a. 2017 \u0645\u0627\u0631\u0633;54(3):212-216. \u062f\u0648\u0649: 10.1136\/jmedgenet-2016-104295. \u0627\u0644\u0646\u0634\u0631 \u0627\u0644\u0625\u0644\u0643\u062a\u0631\u0648\u0646\u064a 2016\u060c 5 \u062f\u064a\u0633\u0645\u0628\u0631.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27799555\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>\u0639\u064a\u0648\u0628 \u0643\u0647\u0631\u0628\u0627\u0626\u064a\u0629 \u0627\u0644\u0642\u0644\u0628 \u0644\u062f\u0649 \u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u0629 \u0628\u0645\u0631\u0636 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0648\u0645\u0631\u0636\u0649 \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0647\u062a\u0634\u064a\u0646\u0633\u0648\u0646 \u062c\u064a\u0644\u0641\u0648\u0631\u062f \u0645\u0639 \u062a\u063a\u064a\u0631\u0627\u062a \u0641\u064a \u0627\u0644\u0635\u0641\u064a\u062d\u0629 \u0627\u0644\u0646\u0648\u0648\u064a\u0629.<\/strong><br \/><\/a>\u0631\u064a\u0641\u064a\u0631\u0627 \u062a\u0648\u0631\u064a\u0633 \u064a\u060c \u0643\u0627\u0644\u0641\u0648 \u0633\u064a \u062c\u064a\u0647\u060c \u0644\u0627\u062a\u0634 \u0623\u060c \u062c\u0648\u0632\u0645\u0627\u0646-\u0645\u0627\u0631\u062a\u064a\u0646\u064a\u0632 \u062c\u064a\u060c \u0643\u0627\u0628\u0627\u0644\u064a\u0631\u0648 \u0622\u0631\u060c \u063a\u0648\u0646\u0632\u0627\u0644\u064a\u0633-\u063a\u0648\u0645\u064a\u0632 \u0633\u064a\u060c \u062e\u064a\u0645\u064a\u0646\u064a\u0632-\u0628\u0648\u0631\u064a\u063a\u0648\u064a\u0631\u0648 \u0625\u0644 \u062c\u064a\u0647\u060c \u063a\u0648\u0627\u062f\u064a\u0643\u0633 \u062c\u0627\u060c \u0623\u0648\u0633\u0648\u0631\u064a\u0648 \u0625\u0641 \u062c\u064a\u060c \u0644\u0648\u0628\u064a\u0632-\u0623\u0648\u062a\u064a\u0646 \u0633\u064a\u060c \u0647\u064a\u0631\u0627\u064a\u0632-\u0645\u0627\u0631\u062a\u064a\u0646\u064a\u0632 \u0623\u060c \u0643\u0627\u0628\u064a\u0644\u0648 \u0625\u0646\u060c \u0641\u0627\u0644\u0645\u064a\u062a\u062c\u0627\u0646\u0627 \u0623 \u060c \u0628\u064a\u0646\u064a\u062a\u064a\u0632 \u0622\u0631\u060c \u062c\u0648\u0631\u062f\u0648\u0646 \u0625\u0644 \u0628\u064a\u060c Jalife J\u060c P\u00e9rez-Pomares JM\u060c Tamargo J\u060c Delp\u00f3n E\u060c Hove-Madsen L\u060c Filgueiras-Rama D\u060c Andr\u00e9s V.<br \/>Proc Natl Acad Sci US A. 2016 Nov 15;113(46):E7250-E7259. Epub 2016 Oct 31.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27400896\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>\u062a\u062c\u0631\u0628\u0629 \u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0645\u062b\u0628\u0637\u0627\u062a \u0628\u0631\u0648\u062a\u064a\u0646 \u0641\u0627\u0631\u0646\u064a\u0633\u064a\u0644\u064a\u0634\u0646 \u0644\u0648\u0646\u0627\u0641\u0627\u0631\u0646\u064a\u0628 \u0648\u0628\u0631\u0627\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0648\u062d\u0645\u0636 \u0632\u0648\u0644\u064a\u062f\u0631\u0648\u0646\u064a\u0643 \u0641\u064a \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0647\u062a\u0634\u064a\u0646\u0633\u0648\u0646 \u062c\u064a\u0644\u0641\u0648\u0631\u062f \u0628\u0631\u0648\u062c\u064a\u0631\u064a\u0627.<\/strong><br \/><\/a>\u062c\u0648\u0631\u062f\u0648\u0646 \u0644\u0628\u060c \u0643\u0644\u0627\u064a\u0646\u0645\u0627\u0646 \u0645\u064a\u060c \u0645\u0627\u0633\u0627\u0631\u0648 \u062c\u064a\u060c \u062f\u0627\u062c\u0648\u0633\u062a\u064a\u0646\u0648 \u0622\u0631 \u0628\u064a \u0627\u0644\u0623\u0628\u060c \u0634\u0627\u0628\u064a\u0644 \u0625\u062a\u0634\u060c \u062c\u064a\u0631\u0647\u0627\u0631\u062f-\u0647\u064a\u0631\u0645\u0627\u0646 \u0625\u0645\u060c \u0633\u0645\u0648\u062a \u0625\u0644 \u0628\u064a\u060c \u062c\u0648\u0631\u062f\u0648\u0646 \u0633\u0645\u060c \u0643\u0644\u064a\u0641\u0644\u0627\u0646\u062f \u0622\u0631 \u0625\u062a\u0634\u060c \u0646\u0627\u0632\u0627\u0631\u064a\u0627\u0646 \u0623\u060c \u0633\u0646\u0627\u064a\u062f\u0631 \u0628\u064a \u062f\u064a\u060c \u0623\u0648\u0644\u0631\u064a\u0634 \u0646\u064a\u0648\u062c\u064a\u0631\u0633\u064a\u060c \u0633\u064a\u0644\u0641\u064a\u0631\u0627 VM\u060c \u0644\u064a\u0627\u0646\u062c \u0625\u0645 \u062c\u064a\u060c \u0643\u0648\u064a\u0646 \u0625\u0646\u060c \u0645\u064a\u0644\u0631 \u062f\u064a \u062a\u064a\u060c \u0647\u0648\u0647 \u0633\u064a\u060c \u062f\u0627\u062a\u0648\u0646 \u0622\u060c \u0644\u064a\u062a\u0644\u0641\u064a\u0644\u062f \u0643\u064a\u0647\u060c \u062c\u0631\u064a\u0631 \u0625\u0645 \u0625\u0645\u060c \u0643\u064a\u0631\u0627\u0646 \u0645\u064a\u063a\u0627\u0648\u0627\u0637.<br \/>\u0627\u0644\u062a\u0648\u0632\u064a\u0639. 2016 \u064a\u0648\u0644\u064a\u0648 12\u061b 134 (2): 114-25. doi: 10.1161\/CIRCULATIONAHA.116.022188.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26564085\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0647\u062a\u0634\u064a\u0646\u0633\u0648\u0646-\u062c\u064a\u0644\u0641\u0648\u0631\u062f.<\/strong><br \/><\/a>\u0623\u0648\u0644\u0631\u064a\u0634 \u0646\u064a\u0648\u062c\u064a\u0631\u0633\u064a\u060c \u062c\u0648\u0631\u062f\u0648\u0646 \u0625\u0644 \u0628\u064a.<br \/>Handb Clin Neurol. 2015\u061b132:249-64.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24795390\"><strong>\u062a\u0623\u062b\u064a\u0631 \u0645\u062b\u0628\u0637\u0627\u062a \u0627\u0644\u0641\u0627\u0631\u0646\u064a\u0633\u064a\u0644 \u0639\u0644\u0649 \u0627\u0644\u0628\u0642\u0627\u0621 \u0639\u0644\u0649 \u0642\u064a\u062f \u0627\u0644\u062d\u064a\u0627\u0629 \u0641\u064a \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0647\u062a\u0634\u064a\u0646\u0633\u0648\u0646 \u062c\u064a\u0644\u0641\u0648\u0631\u062f \u0628\u0631\u0648\u062c\u064a\u0631\u064a\u0627.<\/strong><br \/><\/a>\u062c\u0648\u0631\u062f\u0648\u0646 \u0625\u0644 \u0628\u064a\u060c \u0645\u0627\u0633\u0627\u0631\u0648 \u062c\u064a\u0647\u060c \u062f\u0627\u062c\u0648\u0633\u062a\u064a\u0646\u0648 \u0622\u0631 \u0628\u064a \u0627\u0644\u0623\u0628\u060c \u0643\u0627\u0645\u0628\u0644 \u0625\u0633 \u0625\u064a\u060c \u0628\u0631\u0627\u0632\u064a\u064a\u0631 \u062c\u064a\u0647\u060c \u0628\u0631\u0627\u0648\u0646 \u062f\u0628\u0644\u064a\u0648 \u062a\u064a\u060c \u0643\u0644\u0627\u064a\u0646\u0645\u0627\u0646 \u0625\u0645 \u0625\u064a\u060c \u0643\u064a\u0631\u0627\u0646 \u0625\u0645 \u062f\u0628\u0644\u064a\u0648\u061b \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u062a\u0639\u0627\u0648\u0646\u064a\u0629 \u0644\u0645\u0631\u0636 \u0628\u0631\u0648\u062c\u064a\u0631\u064a\u0627.<br \/>\u0627\u0644\u062a\u0648\u0632\u064a\u0639. 1 \u064a\u0648\u0644\u064a\u0648 2014\u061b 130(1): 27-34. doi: 10.1161\/CIRCULATIONAHA.113.008285. Epub 2 \u0645\u0627\u064a\u0648 2014.<\/p>\n<p><strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24456199\">\u0627\u0644\u0645\u0638\u0627\u0647\u0631 \u0627\u0644\u062c\u0644\u062f\u064a\u0629 \u0627\u0644\u0623\u0648\u0644\u064a\u0629 \u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0647\u062a\u0634\u064a\u0646\u0633\u0648\u0646-\u062c\u064a\u0644\u0641\u0648\u0631\u062f \u0628\u0631\u0648\u062c\u064a\u0631\u064a\u0627.<\/a>\u00a0<\/strong>Rork JF\u060c Huang JT\u060c Gordon LB\u060c Kleinman M\u060c Kieran MW\u060c Liang MG. Pediatr Dermatol. 2014 Jan 24: 1-7. doi: 10.1111\/pde.12284.<\/p>\n<p class=\"desc\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23897869\"><b>\u0639\u0635\u0628\u064a<\/b>\u00a0<b>\u0633\u0645\u0627\u062a<\/b>\u00a0\u0644\u00a0<b>\u0647\u062a\u0634\u064a\u0646\u0633\u0648\u0646-\u062c\u064a\u0644\u0641\u0648\u0631\u062f<\/b>\u00a0\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0628\u0639\u062f \u0627\u0644\u0639\u0644\u0627\u062c \u0628\u0644\u0648\u0646\u0648\u0641\u0627\u0631\u0646\u064a\u0628.<br \/><\/a>\u0623\u0648\u0644\u0631\u064a\u0634 \u0646\u064a\u0648\u062c\u064a\u0631\u0633\u064a, \u0643\u064a\u0631\u0627\u0646 \u0645\u064a\u063a\u0627\u0648\u0627\u0637, \u0645\u064a\u0644\u0631 DT, \u062c\u0648\u0631\u062f\u0648\u0646 \u0631\u0637\u0644, \u062a\u0634\u0648 YJ, \u0633\u064a\u0644\u0641\u064a\u0631\u0627 VM, \u062c\u064a\u0648\u0628\u064a-\u0647\u064a\u0631\u062f\u0631 A, \u0646\u064a\u0648\u0628\u064a\u0631\u062c \u062f, \u0643\u0644\u0627\u064a\u0646\u0645\u0627\u0646 \u0644\u064a. <i>\u0637\u0628 \u0627\u0644\u0623\u0639\u0635\u0627\u0628<\/i>. 30 \u064a\u0648\u0644\u064a\u0648 2013\u061b81(5):427-30. doi: 10.1212\/WNL.0b013e31829d85c0. Epub 28 \u064a\u0648\u0646\u064a\u0648 2013.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23179651\"><b>\u0627\u0644\u062a\u0635\u0648\u064a\u0631<\/b>\u00a0<b>\u0635\u0641\u0627\u062a<\/b>\u00a0\u0644\u00a0<b>\u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629 \u0627\u0644\u062f\u0645\u0627\u063a\u064a\u0629<\/b>\u00a0<b>\u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0634\u0631\u0627\u064a\u064a\u0646<\/b>\u00a0\u0648\u00a0<b>\u0633\u0643\u062a\u0629 \u062f\u0645\u0627\u063a\u064a\u0629<\/b>\u00a0\u0641\u064a \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0647\u062a\u0634\u064a\u0646\u0633\u0648\u0646-\u062c\u064a\u0644\u0641\u0648\u0631\u062f.<\/a> \u0633\u064a\u0644\u0641\u064a\u0631\u0627 \u0641\u064a \u0625\u0645\u060c \u062c\u0648\u0631\u062f\u0648\u0646 \u0625\u0644 \u0628\u064a\u060c \u0623\u0648\u0631\u0628\u0627\u062e \u062f\u064a \u0628\u064a\u060c \u0643\u0627\u0645\u0628\u0644 \u0625\u0633 \u0625\u064a\u060c \u0645\u0627\u0634\u0627\u0646 \u062c\u064a \u062a\u064a\u060c \u0623\u0648\u0644\u0631\u064a\u0634 \u0625\u0646 \u062c\u064a\u0647.<br \/><i>AJNR Am J Neuroradiol<\/i>. 2013 \u0645\u0627\u064a\u0648\u061b34(5):1091-7. doi: 10.3174\/ajnr.A3341. Epub 22 \u0646\u0648\u0641\u0645\u0628\u0631 2012.<\/p>\n<p class=\"desc\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22460337\"><b>\u062a\u0634\u0648\u0647\u0627\u062a \u0627\u0644\u0648\u062c\u0647 \u0648\u0627\u0644\u062c\u0645\u062c\u0645\u0629<\/b>\u00a0\u0641\u064a\u00a0<b>\u0647\u062a\u0634\u064a\u0646\u0633\u0648\u0646<\/b>-\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u062c\u064a\u0644\u0641\u0648\u0631\u062f \u0628\u0631\u0648\u062c\u064a\u0631\u064a\u0627.<br \/><\/a>\u0623\u0648\u0644\u0631\u064a\u0634 NJ, \u0633\u064a\u0644\u0641\u064a\u0631\u0627 VM, \u0643\u0627\u0645\u0628\u0644 SE, \u062c\u0648\u0631\u062f\u0648\u0646 \u0644\u0628. <i>AJNR Am J Neuroradiol<\/i>. 2012 \u0633\u0628\u062a\u0645\u0628\u0631;33(8):1512-8. \u062f\u0648\u0649: 10.3174\/ajnr.A3088. \u0627\u0644\u0646\u0634\u0631 \u0627\u0644\u0625\u0644\u0643\u062a\u0631\u0648\u0646\u064a 2012\u060c 29 \u0645\u0627\u0631\u0633.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23012407\"><b>\u062a\u062c\u0631\u0628\u0629 \u0633\u0631\u064a\u0631\u064a\u0629<\/b>\u00a0\u0645\u0646 \u0623\u00a0<b>\u0641\u0627\u0631\u0646\u064a\u0633\u064a\u0644 \u062a\u0631\u0627\u0646\u0633\u0641\u064a\u0631\u0627\u0632<\/b>\u00a0<b>\u0627\u0644\u0645\u0627\u0646\u0639<\/b>\u00a0\u0641\u064a\u00a0<b>\u0623\u0637\u0641\u0627\u0644<\/b>\u00a0\u0645\u0639\u00a0<b>\u0647\u062a\u0634\u064a\u0646\u0633\u0648\u0646<\/b>-\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u062c\u064a\u0644\u0641\u0648\u0631\u062f \u0628\u0631\u0648\u062c\u064a\u0631\u064a\u0627.<\/a> \u062c\u0648\u0631\u062f\u0648\u0646 \u0625\u0644 \u0628\u064a\u060c \u0643\u0644\u0627\u064a\u0646\u0645\u0627\u0646 \u0625\u0645 \u0625\u064a\u060c \u0645\u064a\u0644\u0631 \u062f\u064a \u062a\u064a\u060c \u0646\u064a\u0648\u0628\u064a\u0631\u062c \u062f\u064a \u0625\u0633\u060c \u062c\u064a\u0648\u0628\u064a-\u0647\u064a\u0631\u062f\u0631 \u0625\u064a\u0647\u060c \u062c\u064a\u0631\u0647\u0627\u0631\u062f \u0647\u064a\u0631\u0645\u0627\u0646 \u0625\u0645\u060c \u0633\u0645\u0648\u062a \u0625\u0644 \u0628\u064a\u060c \u062c\u0648\u0631\u062f\u0648\u0646 \u0633\u064a \u0625\u0645\u060c \u0643\u0644\u064a\u0641\u0644\u0627\u0646\u062f \u0622\u0631\u060c \u0633\u0646\u0627\u064a\u062f\u0631 \u0628\u064a \u062f\u064a\u060c \u0641\u0644\u064a\u062c\u0648\u0631 \u0628\u064a\u060c \u0628\u064a\u0634\u0648\u0628 \u062f\u0628\u0644\u064a\u0648 \u0622\u0631\u060c \u0633\u062a\u0627\u062a\u0643\u064a\u0641\u064a\u062a\u0634 \u0628\u064a\u060c \u0631\u064a\u062c\u064a\u0646 \u0625\u064a\u0647\u060c \u0633\u0648\u0646\u064a\u0633 \u0625\u064a\u0647\u060c \u0631\u0627\u064a\u0644\u064a \u0625\u0633\u060c \u0628\u0644\u0648\u0633\u0643\u064a \u0633\u064a\u060c \u0643\u0648\u0631\u064a\u0627 \u0623\u060c \u0643\u0648\u064a\u0646 \u0625\u0646\u060c \u0623\u0648\u0644\u0631\u064a\u0634 \u0646\u064a\u0648\u062c\u064a\u0631\u0633\u064a\u060c \u0646\u0627\u0632\u0627\u0631\u064a\u0627\u0646 \u0623\u060c \u0644\u064a\u0627\u0646\u063a \u0645\u0644\u063a\u060c \u0647\u0648\u0647 \u0633\u064a\u060c \u0634\u0648\u0627\u0631\u062a\u0632\u0645\u0627\u0646 A\u060c \u0643\u064a\u0631\u0627\u0646 \u0645\u064a\u063a\u0627\u0648\u0627\u0637. <i>\u0625\u062c\u0631\u0627\u0621\u0627\u062a \u0627\u0644\u0623\u0643\u0627\u062f\u064a\u0645\u064a\u0629 \u0627\u0644\u0648\u0637\u0646\u064a\u0629 \u0644\u0644\u0639\u0644\u0648\u0645 \u0628\u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629<\/i>. 9 \u0623\u0643\u062a\u0648\u0628\u0631 2012\u061b 109(41): 16666-71. doi: 10.1073\/pnas.1202529109. Epub 24 \u0633\u0628\u062a\u0645\u0628\u0631 2012<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22083160\"><b>\u0627\u0644\u0622\u0644\u064a\u0627\u062a<\/b>\u00a0\u0644\u00a0<b>\u0633\u0627\u0628\u0642 \u0644\u0623\u0648\u0627\u0646\u0647<\/b>\u00a0<b>\u0648\u0639\u0627\u0626\u064a<\/b>\u00a0<b>\u0634\u064a\u062e\u0648\u062e\u0629<\/b>\u00a0\u0641\u064a\u00a0<b>\u0623\u0637\u0641\u0627\u0644<\/b>\u00a0\u0645\u0639\u00a0<b>\u0647\u062a\u0634\u064a\u0646\u0633\u0648\u0646<\/b>-\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u062c\u064a\u0644\u0641\u0648\u0631\u062f \u0628\u0631\u0648\u062c\u064a\u0631\u064a\u0627.<\/a> \u062c\u064a\u0631\u0647\u0627\u0631\u062f \u0647\u064a\u0631\u0645\u0627\u0646 \u0645\u060c \u0633\u0645\u0648\u062a \u0625\u0644 \u0628\u064a\u060c \u0648\u064a\u0643 \u0625\u0646\u060c \u0643\u064a\u0631\u0627\u0646 \u0625\u0645 \u062f\u0628\u0644\u064a\u0648\u060c \u0643\u0644\u0627\u064a\u0646\u0645\u0627\u0646 \u0625\u0645 \u0625\u064a\u060c \u0645\u064a\u0644\u0631 \u062f\u064a \u062a\u064a\u060c \u0634\u0648\u0627\u0631\u062a\u0632\u0645\u0627\u0646 \u0625\u064a\u0647\u060c \u062c\u064a\u0648\u0628\u064a \u0647\u0648\u0631\u062f\u0631 \u0625\u064a\u0647\u060c \u0646\u064a\u0648\u0628\u064a\u0631\u062c \u062f\u064a\u060c \u062c\u0648\u0631\u062f\u0648\u0646 \u0625\u0644 \u0628\u064a. <i>\u0627\u0631\u062a\u0641\u0627\u0639 \u0636\u063a\u0637 \u0627\u0644\u062f\u0645<\/i>. 2012 \u064a\u0646\u0627\u064a\u0631\u061b59(1):92-7. doi: 10.1161\/HYPERTENSIONAHA.111.180919. Epub 2011 \u0646\u0648\u0641\u0645\u0628\u0631 14.<\/p>\n<p class=\"desc\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22752073\"><strong>\u062f\u0631\u0627\u0633\u0629 \u0645\u0633\u062a\u0642\u0628\u0644\u064a\u0629 \u0644\u0644\u0645\u0638\u0627\u0647\u0631 \u0627\u0644\u0634\u0639\u0627\u0639\u064a\u0629 \u0641\u064a \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0647\u062a\u0634\u064a\u0646\u0633\u0648\u0646 \u062c\u064a\u0644\u0641\u0648\u0631\u062f.<\/strong><br \/><\/a>\u0643\u0644\u064a\u0641\u0644\u0627\u0646\u062f RH\u060c \u062c\u0648\u0631\u062f\u0648\u0646 LB\u060c \u0643\u0644\u0627\u064a\u0646\u0645\u0627\u0646 ME\u060c \u0645\u064a\u0644\u0631 DT\u060c \u062c\u0648\u0631\u062f\u0648\u0646 CM\u060c \u0633\u0646\u0627\u064a\u062f\u0631 BD\u060c \u0646\u0627\u0632\u0627\u0631\u064a\u0627\u0646 A\u060c \u062c\u064a\u0648\u0628\u064a \u0647\u0648\u0631\u062f\u0631 A\u060c \u0646\u064a\u0648\u0628\u064a\u0631\u062c D\u060c \u0643\u064a\u0631\u0627\u0646 MW. <i>\u0637\u0628 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0627\u0644\u0634\u0639\u0627\u0639\u064a<\/i>. 2012 \u0633\u0628\u062a\u0645\u0628\u0631\u061b42(9):1089-98. doi: 10.1007\/s00247-012-2423-1. Epub 2012 \u064a\u0648\u0644\u064a\u0648 1.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21980471\"><b>\u0642\u0644\u064a\u0644<\/b>\u00a0\u0648\u00a0<b>\u0639\u0627\u0644\u064a<\/b>\u00a0<b>\u0627\u0644\u062a\u0639\u0628\u064a\u0631<\/b>\u00a0<b>\u0627\u0644\u0623\u0644\u064a\u0644\u0627\u062a<\/b>\u00a0\u062c\u064a\u0646 LMNA: \u0627\u0644\u0622\u062b\u0627\u0631 \u0627\u0644\u0645\u062a\u0631\u062a\u0628\u0629 \u0639\u0644\u0649 \u062a\u0637\u0648\u0631 \u0645\u0631\u0636 \u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0635\u0641\u064a\u062d\u0629.<\/a> \u0631\u0648\u062f\u0631\u064a\u062c\u064a\u0632 \u0633\u060c \u0625\u0631\u064a\u0643\u0633\u0648\u0646 \u0645. <i>\u0628\u0644\u0648\u0633 \u0648\u0646<\/i>. 2011\u061b6(9):e25472. doi: 10.1371\/journal.pone.0025472. Epub 2011 \u0633\u0628\u062a\u0645\u0628\u0631 29.<br \/><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21445982\"><b><br \/>\u0647\u062a\u0634\u064a\u0646\u0633\u0648\u0646-\u062c\u064a\u0644\u0641\u0648\u0631\u062f<\/b>\u00a0<b>\u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629<\/b>\u00a0\u0647\u0648\u00a0<b>\u0647\u064a\u0643\u0644\u064a<\/b>\u00a0\u062e\u0644\u0644 \u0627\u0644\u062a\u0646\u0633\u062c.<\/a> \u062c\u0648\u0631\u062f\u0648\u0646 CM\u060c \u062c\u0648\u0631\u062f\u0648\u0646 LB\u060c \u0633\u0646\u0627\u064a\u062f\u0631 BD\u060c \u0646\u0627\u0632\u0627\u0631\u064a\u0627\u0646 A\u060c \u0643\u0648\u064a\u0646 N\u060c \u0647\u0648\u0647 S\u060c \u062c\u064a\u0648\u0628\u064a \u0647\u0648\u0631\u062f\u0631 A\u060c \u0646\u064a\u0648\u0628\u064a\u0631\u062c D\u060c \u0643\u0644\u064a\u0641\u0644\u0627\u0646\u062f R\u060c \u0643\u0644\u0627\u064a\u0646\u0645\u0627\u0646 M\u060c \u0645\u064a\u0644\u0631 DT\u060c \u0643\u064a\u0631\u0627\u0646 MW. <i>\u062c\u064a\u0647 \u0628\u0648\u0646 \u0645\u064a\u0646\u0631 \u0631\u064a\u0633<\/i>. 2011 \u064a\u0648\u0644\u064a\u0648;26(7):1670-9. \u062f\u0648\u0649: 10.1002\/jbmr.392.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20798379\"><b>\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0642\u0644\u0628 \u0648\u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629<\/b>\u00a0\u0641\u064a\u00a0<b>\u0647\u062a\u0634\u064a\u0646\u0633\u0648\u0646<\/b>-\u0645\u0631\u0636 \u062c\u064a\u0644\u0641\u0648\u0631\u062f \u0628\u0631\u0648\u062c\u064a\u0631\u064a\u0627: \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629<b>\u0639\u0644\u0645 \u0627\u0644\u0623\u0645\u0631\u0627\u0636<\/b>\u00a0\u0645\u0646 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629.<\/a> \u0623\u0648\u0644\u064a\u0641 \u0645\u060c \u0647\u0627\u0631\u062a\u0646 \u0622\u064a\u060c \u0645\u064a\u062a\u0634\u0644 \u0622\u0631\u060c \u0628\u064a\u0631\u0632 \u062c\u064a\u0647 \u0643\u064a\u0647\u060c \u062c\u0627\u0628\u0627\u0644\u064a \u0643\u064a\u0647\u060c \u0643\u0627\u0648 \u0643\u064a\u0647\u060c \u0625\u0631\u062f\u0648\u0633 \u0625\u0645 \u0622\u0631\u060c \u0628\u0644\u064a\u0631 \u0633\u064a\u060c \u0641\u0648\u0646\u0643\u064a \u0628\u064a\u060c \u0633\u0645\u0648\u062a \u0625\u0644\u060c \u062c\u064a\u0631\u0647\u0627\u0631\u062f \u0647\u064a\u0631\u0645\u0627\u0646 \u0625\u0645\u060c \u0645\u0627\u0634\u0627\u0646 \u062c\u064a\u0647 \u062a\u064a\u060c \u0643\u0648\u062a\u064a\u0633 \u0622\u0631\u060c \u0641\u064a\u0631\u0645\u0627\u0646\u064a \u0622\u0631\u060c \u0643\u0648\u0644\u064a\u0646\u0632 \u0625\u0641 \u0625\u0633\u060c \u0648\u0627\u064a\u062a \u062a\u064a \u0625\u0646\u060c \u0646\u0627\u0628\u0644 \u0625\u064a \u062c\u064a\u060c \u062c\u0648\u0631\u062f\u0648\u0646 \u0625\u0644 \u0628\u064a. <i>\u062a\u0635\u0644\u0628 \u0627\u0644\u0634\u0631\u0627\u064a\u064a\u0646 \u0627\u0644\u062e\u062b\u0627\u0631\u064a \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629 \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u0648\u0639\u0627\u0626\u064a\u0629<\/i>. 2010 \u0646\u0648\u0641\u0645\u0628\u0631\u061b30(11):2301-9. doi: 10.1161\/ATVBAHA.110.209460. Epub 2010 \u0623\u063a\u0633\u0637\u0633 26.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19236595\"><b>\u0647\u062a\u0634\u064a\u0646\u0633\u0648\u0646-\u062c\u064a\u0644\u0641\u0648\u0631\u062f<\/b>\u00a0<b>\u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629<\/b>\u00a0<b>\u0645\u062a\u0644\u0627\u0632\u0645\u0629<\/b>:\u00a0<b>\u0634\u0641\u0648\u064a<\/b>\u00a0\u0648\u0627\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u0638\u0627\u0647\u0631\u064a\u0629 \u0644\u0644\u0648\u062c\u0647 \u0648\u0627\u0644\u062c\u0645\u062c\u0645\u0629.<\/a> Domingo DL, Trujillo MI, Council SE, Merideth MA, Gordon LB, Wu T, Introne WJ, Gahl WA, Hart TC. <i>\u0634\u0641\u0648\u064a<\/i><i>\u00a0<\/i><i>\u062f\u064a\u0633<\/i>. 2009 \u0623\u0628\u0631\u064a\u0644\u061b15(3):187-95. doi: 10.1111\/j.1601-0825.2009.01521.x. Epub 2009 \u0641\u0628\u0631\u0627\u064a\u0631 19.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18334552\"><b>\u0645\u0633\u062a\u0647\u062f\u0641<\/b>\u00a0<b>\u0645\u064f\u062d\u0648\u064e\u0651\u0631 \u0648\u0631\u0627\u062b\u064a\u064b\u0627<\/b>\u00a0<b>\u062a\u0639\u0628\u064a\u0631<\/b>\u00a0\u0627\u0644\u062a\u0627\u0628\u0639\u00a0<b>\u0637\u0641\u0631\u0629<\/b>\u00a0<b>\u0645\u0633\u0628\u0628<\/b>\u00a0\u064a\u0624\u062f\u064a \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0647\u062a\u0634\u064a\u0646\u0633\u0648\u0646 \u062c\u064a\u0644\u0641\u0648\u0631\u062f \u0625\u0644\u0649 \u0645\u0631\u0636 \u0628\u0634\u0631\u0648\u064a \u062a\u0643\u0627\u062b\u0631\u064a \u0648\u062a\u0646\u0643\u0633\u064a.<\/a> \u0633\u0627\u062c\u064a\u0644\u064a\u0648\u0633 \u0647\u0640\u060c \u0631\u0648\u0632\u064a\u0646\u062c\u0627\u0631\u062f\u062a\u0646 \u064a\u060c \u0647\u0627\u0646\u064a\u0641 \u0645\u060c \u0625\u0631\u062f\u0648\u0633 \u0625\u0645 \u0622\u0631\u060c \u0631\u0648\u0632\u064a\u0644 \u0628\u060c \u0643\u0648\u0644\u064a\u0646\u0632 \u0625\u0641 \u0625\u0633\u060c \u0625\u0631\u064a\u0643\u0633\u0648\u0646 \u0645. <i>\u0645\u062c\u0644\u0629 \u0639\u0644\u0648\u0645 \u0627\u0644\u062e\u0644\u064a\u0629<\/i>. 2008 \u0623\u0628\u0631\u064a\u0644 1\u061b 121 (\u0627\u0644\u062c\u0632\u0621 7): 969-78. doi: 10.1242\/jcs.022913. Epub 2008 \u0645\u0627\u0631\u0633 11.<\/p>\n<p class=\"desc\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18708427\"><b>\u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u0639\u0643\u0633<\/b>\u00a0<b>\u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u0638\u0627\u0647\u0631\u064a<\/b>\u00a0\u0641\u064a\u00a0<b>\u0641\u0623\u0631<\/b>\u00a0\u0646\u0645\u0648\u0630\u062c \u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0647\u062a\u0634\u064a\u0646\u0633\u0648\u0646-\u062c\u064a\u0644\u0641\u0648\u0631\u062f \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629.<br \/><\/a>\u0633\u0627\u062c\u064a\u0644\u064a\u0648\u0633 \u0625\u062a\u0634\u060c \u0631\u0648\u0632\u064a\u0646\u062c\u0627\u0631\u062f\u062a\u0646 \u0648\u0627\u064a\u060c \u0634\u0645\u064a\u062f\u062a \u0625\u064a\u060c \u0633\u0648\u0646\u0627\u0628\u0646\u062f \u0633\u064a\u060c \u0631\u0648\u0632\u064a\u0644 \u0628\u064a\u060c \u0625\u0631\u064a\u0643\u0633\u0648\u0646 \u0625\u0645. <i>\u0645\u062c\u0644\u0629 \u0627\u0644\u0637\u0628 \u0648\u0627\u0644\u062c\u064a\u0646\u0627\u062a<\/i>. 2008 \u062f\u064a\u0633\u0645\u0628\u0631;45(12):794-801. \u062f\u0648\u0649: 10.1136\/jmg.2008.060772. \u0627\u0644\u0646\u0634\u0631 \u0627\u0644\u0625\u0644\u0643\u062a\u0631\u0648\u0646\u064a 2008\u060c 15 \u0623\u063a\u0633\u0637\u0633.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18256394\"><b>\u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u0638\u0627\u0647\u0631\u064a<\/b>\u00a0\u0648\u00a0<b>\u062f\u0648\u0631\u0629<\/b>\u00a0\u0644\u00a0<b>\u0647\u062a\u0634\u064a\u0646\u0633\u0648\u0646<\/b>-\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u062c\u064a\u0644\u0641\u0648\u0631\u062f \u0628\u0631\u0648\u062c\u064a\u0631\u064a\u0627.<\/a> \u0645\u064a\u0631\u064a\u062f\u064a\u062b \u0625\u0645 \u0625\u064a\u0647\u060c \u062c\u0648\u0631\u062f\u0648\u0646 \u0625\u0644 \u0628\u064a\u060c \u0643\u0644\u0627\u0648\u0633 \u0625\u0633\u060c \u0633\u0627\u0634\u062f\u064a\u0641 \u0641\u064a\u060c \u0633\u0645\u064a\u062b \u0625\u064a\u0647 \u0633\u064a\u060c \u0628\u064a\u0631\u064a \u0625\u0645 \u0628\u064a\u060c \u0628\u0631\u0648\u064a\u0631 \u0633\u064a \u0633\u064a\u060c \u0632\u0627\u0644\u064a\u0648\u0633\u0643\u064a \u0633\u064a\u060c \u0643\u064a\u0645 \u0625\u062a\u0634 \u062c\u064a\u0647\u060c \u0633\u0648\u0644\u0648\u0645\u0648\u0646 \u0628\u064a\u060c \u0628\u0631\u0648\u0643\u0633 \u0628\u064a \u0628\u064a\u060c \u062c\u064a\u0631\u0628\u0631 \u0625\u0644 \u0625\u062a\u0634\u060c \u062a\u0648\u0631\u0646\u0631 \u0625\u0645 \u0625\u0644\u060c \u062f\u0648\u0645\u064a\u0646\u063a\u0648 \u062f\u064a \u0625\u0644\u060c \u0647\u0627\u0631\u062a \u062a\u064a \u0633\u064a\u060c \u062c\u0631\u0627\u0641 \u062c\u064a\u0647\u060c \u0631\u064a\u0646\u0648\u0644\u062f\u0632 \u062c\u064a\u0647 \u0633\u064a\u060c \u062c\u0631\u0648\u0628\u0645\u0627\u0646 \u0625\u064a\u0647\u060c \u064a\u0627\u0646\u0648\u0641\u0633\u0643\u064a \u062c\u064a\u0647 \u0625\u064a\u0647\u060c \u062c\u064a\u0631\u0647\u0627\u0631\u062f \u0647\u064a\u0631\u0645\u0627\u0646 \u0625\u0645\u060c \u0643\u0648\u0644\u064a\u0646\u0632 \u0625\u0641 \u0625\u0633\u060c \u0646\u0627\u0628\u0644 \u0625\u064a \u062c\u064a\u060c \u0643\u0627\u0646\u0648\u0646 \u0622\u0631 \u0623\u0648 3\u060c \u062c\u0627\u0644 \u062f\u0628\u0644\u064a\u0648 \u0625\u064a\u0647\u060c \u0625\u0646\u062a\u0631\u0648\u0646 \u062f\u0628\u0644\u064a\u0648 \u062c\u064a\u0647. <i>\u0646\u064a\u0648 \u0625\u0646\u062c\u0644\u0646\u062f \u062c\u064a\u0647 \u0645\u064a\u062f<\/i>. 2008 \u0641\u0628\u0631\u0627\u064a\u0631 7;358(6):592-604. \u062f\u0648\u0649: 10.1056\/NEJMoa0706898.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17908771\"><b>\u062c\u062f\u064a\u062f<\/b>\u00a0<b>\u0627\u0644\u0646\u0647\u062c<\/b>\u00a0\u0644\u00a0<b>\u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629<\/b>.<\/a> Kieran MW, Gordon L, Kleinman M. \u0637\u0628 \u0627\u0644\u0623\u0637\u0641\u0627\u0644. \u0623\u0643\u062a\u0648\u0628\u0631 2007\u061b 120(4): 834-41. \u0645\u0631\u0627\u062c\u0639\u0629. \u062a\u0635\u062d\u064a\u062d \u0641\u064a: <i>\u0637\u0628 \u0627\u0644\u0623\u0637\u0641\u0627\u0644<\/i>. 2007 \u062f\u064a\u0633\u0645\u0628\u0631\u061b120(6):1405.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17908770\"><b>\u062a\u0637\u0648\u0631 \u0627\u0644\u0645\u0631\u0636<\/b>\u00a0\u0641\u064a\u00a0<b>\u0647\u062a\u0634\u064a\u0646\u0633\u0648\u0646-\u062c\u064a\u0644\u0641\u0648\u0631\u062f<\/b>\u00a0\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629: \u0627\u0644\u062a\u0623\u062b\u064a\u0631 \u0639\u0644\u0649 \u0627\u0644\u0646\u0645\u0648 \u0648\u0627\u0644\u062a\u0637\u0648\u0631.<\/a> \u062c\u0648\u0631\u062f\u0648\u0646 \u0644\u0628\u060c \u0643\u0645 \u0645\u0643\u0627\u0631\u062a\u0646\u060c \u062c\u064a\u0648\u0628\u064a-\u0647\u0648\u0631\u062f\u0631 A\u060c \u0645\u0627\u0634\u0627\u0646 \u062c\u064a \u062a\u064a\u060c \u0643\u0627\u0645\u0628\u0644 SE\u060c \u0628\u064a\u0631\u0646\u0632 SD\u060c \u0643\u064a\u0631\u0627\u0646 \u0645\u064a\u062c\u0627\u0648\u0627\u062a. <i>\u0637\u0628 \u0627\u0644\u0623\u0637\u0641\u0627\u0644<\/i>. \u0623\u0643\u062a\u0648\u0628\u0631 2007\u061b120(4):824-33.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15756215\"><b>\u0645\u062e\u0641\u0636<\/b>\u00a0<b>\u0623\u062f\u064a\u0628\u0648\u0646\u064a\u0643\u062a\u064a\u0646<\/b>\u00a0\u0648\u00a0<b>\u0627\u0644\u0643\u0648\u0644\u064a\u0633\u062a\u0631\u0648\u0644 \u0627\u0644\u062d\u0645\u064a\u062f<\/b>\u00a0\u0628\u062f\u0648\u0646\u00a0<b>\u0645\u0631\u062a\u0641\u0639<\/b>\u00a0<b>\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u062a\u0641\u0627\u0639\u0644\u064a-\u0633\u064a<\/b>: \u0623\u062f\u0644\u0629 \u0639\u0644\u0649 \u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0627 \u062a\u0635\u0644\u0628 \u0627\u0644\u0634\u0631\u0627\u064a\u064a\u0646 \u0627\u0644\u0645\u0628\u0643\u0631 \u0641\u064a \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0647\u062a\u0634\u064a\u0646\u0633\u0648\u0646 \u062c\u064a\u0644\u0641\u0648\u0631\u062f \u0628\u0631\u0648\u062c\u064a\u0631\u064a\u0627.<\/a> \u062c\u0648\u0631\u062f\u0648\u0646 \u0644\u0628\u060c \u0647\u0627\u0631\u062a\u0646 IA\u060c \u0628\u0627\u062a\u064a \u0645\u064a\u060c \u0644\u064a\u062e\u062a\u0646\u0634\u062a\u0627\u064a\u0646 \u0647. <i>\u0645\u062c\u0644\u0629 \u0637\u0628 \u0627\u0644\u0623\u0637\u0641\u0627\u0644<\/i>. 2005 \u0645\u0627\u0631\u0633\u061b146(3):336-41.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16129833\"><b>\u0645\u062b\u0628\u0637<\/b>\u00a0<b>\u0627\u0644\u0641\u0627\u0631\u0646\u064a\u0633\u064a\u0644\u064a\u0634\u0646<\/b>\u00a0\u064a\u0645\u0646\u0639 \u0627\u0644\u0628\u0631\u0648\u062c\u064a\u0631\u064a\u0646 \u0638\u0647\u0648\u0631 \u0627\u0644\u0641\u0642\u0627\u0639\u0627\u062a \u0627\u0644\u0646\u0648\u0648\u064a\u0629 \u0627\u0644\u0645\u0645\u064a\u0632\u0629 \u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0647\u062a\u0634\u064a\u0646\u0633\u0648\u0646-\u062c\u064a\u0644\u0641\u0648\u0631\u062f\u00a0<b>\u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629<\/b>\u00a0\u0645\u062a\u0644\u0627\u0632\u0645\u0629.<\/a> \u0643\u0627\u0628\u064a\u0644 \u0642\u0628\u0644 \u0627\u0644\u0645\u064a\u0644\u0627\u062f, \u0625\u0631\u062f\u0648\u0633 \u0627\u0644\u0633\u064a\u062f, \u0645\u0627\u062f\u064a\u062c\u0627\u0646 \u062c\u0628, \u0641\u064a\u0648\u0631\u062f\u0627\u0644\u064a\u0633\u064a \u064a \u064a, \u0641\u0627\u0631\u062c\u0627 R, \u0643\u0648\u0646\u064a\u0644\u064a \u0643\u0646, \u062c\u0648\u0631\u062f\u0648\u0646 \u0644\u0628, \u062f\u064a\u0631 CJ, \u0643\u0648\u0643\u0633 \u0623\u062f, \u0643\u0648\u0644\u064a\u0646\u0632 FS. <i>\u0625\u062c\u0631\u0627\u0621\u0627\u062a \u0627\u0644\u0623\u0643\u0627\u062f\u064a\u0645\u064a\u0629 \u0627\u0644\u0648\u0637\u0646\u064a\u0629 \u0644\u0644\u0639\u0644\u0648\u0645 \u0628\u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629<\/i>. 2005 \u0633\u0628\u062a\u0645\u0628\u0631 6\u061b 102(36): 12879-84. Epub 2005 \u0623\u063a\u0633\u0637\u0633 29<\/p>\n<p class=\"details\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15184648\"><b>\u062a\u0631\u0627\u0643\u0645<\/b>\u00a0\u0644\u00a0<b>\u0645\u062a\u062d\u0648\u0644\u0629<\/b>\u00a0<b>\u0644\u0627\u0645\u064a\u0646 \u0623<\/b>\u00a0<b>\u0627\u0644\u0623\u0633\u0628\u0627\u0628<\/b>\u00a0\u062a\u063a\u064a\u0631\u0627\u062a \u062a\u0642\u062f\u0645\u064a\u0629 \u0641\u064a \u0627\u0644\u0628\u0646\u064a\u0629 \u0627\u0644\u0646\u0648\u0648\u064a\u0629 \u0641\u064a \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0647\u062a\u0634\u064a\u0646\u0633\u0648\u0646 \u062c\u064a\u0644\u0641\u0648\u0631\u062f.<\/a> \u062c\u0648\u0644\u062f\u0645\u0627\u0646 RD\u060c \u0634\u0648\u0645\u064a\u0643\u0631 DK\u060c \u0625\u0631\u062f\u0648\u0633 MR\u060c \u0625\u0631\u064a\u0643\u0633\u0648\u0646 M\u060c \u062c\u0648\u0644\u062f\u0645\u0627\u0646 AE\u060c \u062c\u0648\u0631\u062f\u0648\u0646 LB\u060c \u062c\u0631\u0648\u0646\u0628\u0627\u0648\u0645 Y\u060c \u062e\u0648\u0646 S\u060c \u0645\u064a\u0646\u062f\u064a\u0632 M\u060c \u0641\u0627\u0631\u062c\u0627 R\u060c \u0643\u0648\u0644\u064a\u0646\u0632 FS. <i>\u0625\u062c\u0631\u0627\u0621\u0627\u062a \u0627\u0644\u0623\u0643\u0627\u062f\u064a\u0645\u064a\u0629 \u0627\u0644\u0648\u0637\u0646\u064a\u0629 \u0644\u0644\u0639\u0644\u0648\u0645 \u0628\u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629<\/i>. 2004 \u064a\u0648\u0646\u064a\u0648 15;101(24):8963-8. \u0627\u0644\u0646\u0634\u0631 \u0627\u0644\u0625\u0644\u0643\u062a\u0631\u0648\u0646\u064a 2004\u060c 7 \u064a\u0648\u0646\u064a\u0648.<\/p>\n<h4><strong>\u0627\u0644\u0643\u062a\u0628 \u0648\u0627\u0644\u0648\u062b\u0627\u0626\u0642<\/strong><\/h4>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20301300\" target=\"_blank\" rel=\"noopener noreferrer\">\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0647\u062a\u0634\u064a\u0646\u0633\u0648\u0646-\u062c\u064a\u0644\u0641\u0648\u0631\u062f \u0628\u0631\u0648\u062c\u064a\u0631\u064a\u0627.<\/a>\u00a0 \u062c\u0648\u0631\u062f\u0648\u0646 \u0625\u0644 \u0628\u064a\u060c \u0628\u0631\u0627\u0648\u0646 \u062f\u0628\u0644\u064a\u0648 \u062a\u064a\u060c \u0643\u0648\u0644\u064a\u0646\u0632 \u0625\u0641 \u0625\u0633. \u0641\u064a: \u0628\u0627\u062c\u0648\u0646 \u0622\u0631 \u0625\u064a\u0647\u060c \u0628\u064a\u0631\u062f \u062a\u064a \u062f\u064a\u060c \u062f\u0648\u0644\u0627\u0646 \u0633\u064a \u0622\u0631\u060c \u0633\u062a\u064a\u0641\u0646\u0632 \u0643\u064a\u0647\u060c \u0627\u0644\u0645\u062d\u0631\u0631\u0648\u0646. \u062c\u064a\u0646 \u0631\u064a\u0641\u064a\u0648\u0632 [\u0625\u0646\u062a\u0631\u0646\u062a]. \u0633\u064a\u0627\u062a\u0644 (\u0648\u0627\u0634\u0646\u0637\u0646): \u062c\u0627\u0645\u0639\u0629 \u0648\u0627\u0634\u0646\u0637\u0646\u060c \u0633\u064a\u0627\u062a\u0644\u061b 1993-.<br \/>12 \u062f\u064a\u0633\u0645\u0628\u0631 2003 [\u062a\u0645 \u0627\u0644\u062a\u062d\u062f\u064a\u062b \u0641\u064a 6 \u064a\u0646\u0627\u064a\u0631 2011].<\/p>\n<div class=\"wpb_text_column wpb_content_element\">\n<div class=\"wpb_wrapper\">\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20301300\" target=\"_blank\" rel=\"noopener noreferrer\">\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0647\u062a\u0634\u064a\u0646\u0633\u0648\u0646-\u062c\u064a\u0644\u0641\u0648\u0631\u062f \u0628\u0631\u0648\u062c\u064a\u0631\u064a\u0627.<\/a>\u00a0 \u062c\u0648\u0631\u062f\u0648\u0646 \u0625\u0644 \u0628\u064a\u060c \u0628\u0631\u0627\u0648\u0646 \u062f\u0628\u0644\u064a\u0648 \u062a\u064a\u060c \u0643\u0648\u0644\u064a\u0646\u0632 \u0625\u0641 \u0625\u0633. \u0641\u064a: \u0628\u0627\u062c\u0648\u0646 \u0622\u0631 \u0625\u064a\u0647\u060c \u0628\u064a\u0631\u062f \u062a\u064a \u062f\u064a\u060c \u062f\u0648\u0644\u0627\u0646 \u0633\u064a \u0622\u0631\u060c \u0633\u062a\u064a\u0641\u0646\u0632 \u0643\u064a\u0647\u060c \u0627\u0644\u0645\u062d\u0631\u0631\u0648\u0646. \u062c\u064a\u0646 \u0631\u064a\u0641\u064a\u0648\u0632 [\u0625\u0646\u062a\u0631\u0646\u062a]. \u0633\u064a\u0627\u062a\u0644 (\u0648\u0627\u0634\u0646\u0637\u0646): \u062c\u0627\u0645\u0639\u0629 \u0648\u0627\u0634\u0646\u0637\u0646\u060c \u0633\u064a\u0627\u062a\u0644\u061b 1993-.<br \/>12 \u062f\u064a\u0633\u0645\u0628\u0631 2003 [\u062a\u0645 \u0627\u0644\u062a\u062d\u062f\u064a\u062b \u0641\u064a 6 \u064a\u0646\u0627\u064a\u0631 2011].<\/p>\n<p>\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0647\u062a\u0634\u064a\u0646\u0633\u0648\u0646 \u062c\u064a\u0644\u0641\u0648\u0631\u062f \u0628\u0631\u0648\u062c\u064a\u0631\u064a\u0627: \u0631\u0624\u0649 \u062d\u0648\u0644 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0637\u0628\u064a\u0639\u064a\u0629. \u062c\u0648\u0631\u062f\u0648\u0646\u060c \u0644\u064a\u0632\u0644\u064a. \u0627\u0644\u0641\u0635\u0644 \u0641\u064a \u0627\u0644\u0637\u0628\u0639\u0629 \u0627\u0644\u0633\u0627\u0628\u0639\u0629 \u0645\u0646\u00a0<em>\u0643\u062a\u0627\u0628 \u0628\u0631\u0648\u0643\u0644\u0647\u0648\u0631\u0633\u062a \u0639\u0646 \u0627\u0644\u0637\u0628 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u064a \u0648\u0639\u0644\u0645 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629<\/em>\u062d\u0642\u0648\u0642 \u0627\u0644\u0637\u0628\u0639 \u0648\u0627\u0644\u0646\u0634\u0631: 2010.<\/p>\n<p><em>LMNA<\/em>\u00a0\u0648\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0647\u062a\u0634\u064a\u0646\u0633\u0648\u0646-\u062c\u064a\u0644\u0641\u0648\u0631\u062f \u0628\u0631\u0648\u062c\u064a\u0631\u064a\u0627 \u0648\u0627\u0644\u0627\u0639\u062a\u0644\u0627\u0644\u0627\u062a \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0647\u0627. \u062c\u0648\u0631\u062f\u0648\u0646 \u0625\u0644 \u0628\u064a\u060c \u0628\u0631\u0627\u0648\u0646 \u062f\u0628\u0644\u064a\u0648 \u062a\u064a\u060c \u0631\u0648\u062b\u0645\u0627\u0646 \u0625\u0641 \u062c\u064a. \u0641\u064a \u0633\u064a \u062c\u064a \u0625\u0628\u0633\u062a\u064a\u0646\u060c \u0622\u0631 \u0628\u064a \u0625\u0631\u064a\u0643\u0633\u0648\u0646\u060c \u0623. \u0648\u064a\u0646\u0634\u0648 \u0628\u0648\u0631\u064a\u0633 (\u0627\u0644\u0645\u062d\u0631\u0631\u0648\u0646).<em>\u00a0\u0627\u0644\u0623\u062e\u0637\u0627\u0621 \u0627\u0644\u062e\u0644\u0642\u064a\u0629 \u0641\u064a \u0627\u0644\u0646\u0645\u0648: \u0627\u0644\u0623\u0633\u0627\u0633 \u0627\u0644\u062c\u0632\u064a\u0626\u064a \u0644\u0644\u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0641\u064a \u0627\u0644\u062a\u062e\u0644\u0642<\/em>\u00a0(2<sup>\u0627\u062e\u062a\u0635\u0627\u0631 \u0627\u0644\u062b\u0627\u0646\u064a<\/sup>\u00a0\u0646\u064a\u0648\u064a\u0648\u0631\u0643\u060c \u0646\u064a\u0648\u064a\u0648\u0631\u0643: 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[\u2026]<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"\t\t\t\t[vc_row][vc_column][vc_custom_heading text=\"Medical Database\" font_container=\"tag:h1|text_align:center\" use_theme_fonts=\"yes\"][vc_column_text]<strong>What is the International Medical and Research Database?<\/strong>\r\n\r\nWe collect the medical records for children with Progeria from all over the world. Then we look at every aspect of medical care that has been given to the children. We perform statistical analyses, and look at what treatments have worked for maintaining quality of life and what treatments have not worked. Most doctors have only seen one child with Progeria, and they are not sure what to do when the child needs things like heart medications, anesthesia, and proper physical therapy. We have the ability to give advice to the doctors and their families based on this database program.\r\n\r\nThe Progeria Research Foundation is collaborating with Brown University Center for Gerontology and Health Care Research for this wonderful project. The Brown Center has many years of experience with creating and analyzing healthcare databases.\r\n\r\nWe also use the medical records to understand more about the basis of disease in Progeria, which serves as a springboard for new research in Progeria and in the diseases of aging such as heart disease. This may lead to clues for new treatments for the children and for all of us!\r\n\r\nThere has never been a centralized childhood Progeria database from which to draw health care information. This has led to unintentional clinical maltreatment of patients, misdiagnoses and delayed diagnoses, simply because caretakers do not know which medical strategies have been successful with other Progeria children and which have not. The goal of this project is to collect the health care records for children with Progeria and develop a centralized health database for use by health care professionals, medical researchers, and families of children with Progeria.\r\n\r\n<strong>Aims of the Database<\/strong>\r\n<ul>\r\n \t<li>To describe in detail what treatment strategies have been successful, and what treatments have failed for the medical issues faced by children with HGPS. This may help the families and their doctors understand how to best care for children with Progeria.<\/li>\r\n \t<li>To provide health care recommendations to families in non-medical language about the issues that are important to the quality of life for children with HGPS.<\/li>\r\n \t<li>The database is a resource for gaining new insights into the nature of HGPS and into the nature of other diseases such as atherosclerosis, which in turn will serve to stimulate the advancement of new research projects.<\/li>\r\n<\/ul>\r\n<strong>Institutional Review Board Approvals:<\/strong>\r\n\r\nThe PRF Medical and Research Database is Institutional Review Board (IRB) approved by the Rhode Island Hospital and the Brown University Committees on the Protection of Human Subjects. Rhode Island Hospital Federal Wide Assurance FWA00001230, Study CMTT# 0152-01, Brown University Federal Wide Assurance FWA 00004460, Study CMTT# 0211991243\r\n\r\n<strong>Publications Stemming From The Progeria Research Foundation Medical and Research Database<\/strong>\r\n\r\nThe Progeria Research Foundation Medical and Research Database has contributed to the following medical publications:\r\n\r\n<strong>Clinical Care Handbook<\/strong>\r\n\r\n<em>The Progeria Handbook; A Guide for Families and Health Care Providers of Children with Progeria.<\/em> Gordon, Leslie B., Executive Editor. Copyright 2019 by The Progeria Research Foundation. All rights reserved.\r\n\r\n<img src=\"https:\/\/www.progeriaresearch.org\/assets\/images\/iconPDF.gif\" width=\"34\" height=\"20\" \/> <a href=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/01\/Handbook-2018-PDF-One-File-v3-1.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Click here\u00a0<\/a>\u00a0to download the second edition of the Handbook in English.\r\n\r\nThe first edition of the handbook is available in Spanish and Portuguese versions. Translations of the second edition of the handbook in Spanish and Portuguese will be posted when available.\r\n\r\n<a href=\"https:\/\/www.progeriaresearch.org\/assets\/files\/pdf\/PRF%20Handbook%20Spanish.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><img src=\"https:\/\/www.progeriaresearch.org\/assets\/images\/iconPDF.gif\" width=\"34\" height=\"20\" \/><\/a>\u00a0<a href=\"https:\/\/www.progeriaresearch.org\/assets\/files\/pdf\/PRF%20Handbook%20Spanish.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Click here<\/a> to download the Handbook in Spanish.\r\n\r\n<a href=\"https:\/\/www.progeriaresearch.org\/assets\/files\/pdf\/PRF%20Handbook%20Spanish.pdf\"><img src=\"https:\/\/www.progeriaresearch.org\/assets\/images\/iconPDF.gif\" width=\"34\" height=\"20\" \/><\/a>\u00a0<a href=\"https:\/\/www.progeriaresearch.org\/assets\/files\/pdf\/Handbook---Portuguese.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Click here<\/a> to download the Handbook in Portuguese.\r\n\r\n<strong>Journal Articles<\/strong>\r\n\r\n<strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28756152\" target=\"_blank\" rel=\"noopener noreferrer\">Ophthalmologic\u00a0Features\u00a0of\u00a0Progeria.\r\n<\/a><\/strong>Mantagos IS, Kleinman ME, Kieran MW, Gordon LB.\r\nAm J Ophthalmol. 2017 Jul 27. pii: S0002-9394(17)30317-3. doi: 10.1016\/j.ajo.2017.07.020. [Epub ahead of print]\r\n\r\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27920058\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>A\u00a0novel\u00a0somatic\u00a0mutation\u00a0achieves\u00a0partial rescue in a child with Hutchinson-Gilford progeria syndrome.<\/strong>\r\n<\/a>Bar DZ, Arlt MF, Brazier JF, Norris WE, Campbell SE, Chines P, Larrieu D, Jackson SP, Collins FS, Glover TW, Gordon LB.\r\nJ Med Genet. 2017 Mar;54(3):212-216. doi: 10.1136\/jmedgenet-2016-104295. Epub 2016 Dec 5.\r\n\r\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27799555\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Cardiac\u00a0electrical\u00a0defects\u00a0in\u00a0progeroid\u00a0mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations.<\/strong>\r\n<\/a>Rivera-Torres J, Calvo CJ, Llach A, Guzm\u00e1n-Mart\u00ednez G, Caballero R, Gonz\u00e1lez-G\u00f3mez C, Jim\u00e9nez-Borreguero LJ, Guadix JA, Osorio FG, L\u00f3pez-Ot\u00edn C, Herraiz-Mart\u00ednez A, Cabello N, Vallmitjana A, Ben\u00edtez R, Gordon LB, Jalife J, P\u00e9rez-Pomares JM, Tamargo J, Delp\u00f3n E, Hove-Madsen L, Filgueiras-Rama D, Andr\u00e9s V.\r\nProc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7250-E7259. Epub 2016 Oct 31.\r\n\r\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27400896\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Clinical Trial\u00a0of the\u00a0Protein Farnesylation\u00a0Inhibitors\u00a0Lonafarnib, Pravastatin, and Zoledronic Acid in Children With Hutchinson-Gilford Progeria Syndrome.<\/strong>\r\n<\/a>Gordon LB, Kleinman ME, Massaro J, D'Agostino RB Sr, Shappell H, Gerhard-Herman M, Smoot LB, Gordon CM, Cleveland RH, Nazarian A, Snyder BD, Ullrich NJ, Silvera VM, Liang MG, Quinn N, Miller DT, Huh SY, Dowton AA, Littlefield K, Greer MM, Kieran MW.\r\nCirculation. 2016 Jul 12;134(2):114-25. doi: 10.1161\/CIRCULATIONAHA.116.022188.\r\n\r\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26564085\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Hutchinson-Gilford progeria syndrome.<\/strong>\r\n<\/a>Ullrich NJ, Gordon LB.\r\nHandb Clin Neurol. 2015;132:249-64.\r\n\r\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24795390\"><strong>Impact\u00a0of\u00a0farnesylation\u00a0inhibitors\u00a0on\u00a0survival\u00a0in hutchinson-gilford progeria syndrome.<\/strong>\r\n<\/a>Gordon LB, Massaro J, D'Agostino RB Sr, Campbell SE, Brazier J, Brown WT, Kleinman ME, Kieran MW; Progeria Clinical Trials Collaborative.\r\nCirculation. 2014 Jul 1;130(1):27-34. doi: 10.1161\/CIRCULATIONAHA.113.008285. Epub 2014 May 2.\r\n\r\n<strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24456199\">Initial\u00a0Cutaneous\u00a0Manifestations of Hutchinson-Gilford Progeria Syndrome.<\/a>\u00a0<\/strong>Rork JF, Huang JT, Gordon LB, Kleinman M, Kieran MW, Liang MG. Pediatr Dermatol. 2014 Jan 24: 1-7. doi: 10.1111\/pde.12284.\r\n<p class=\"desc\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23897869\"><b>Neurologic<\/b>\u00a0<b>features<\/b>\u00a0of\u00a0<b>Hutchinson-Gilford<\/b>\u00a0progeria syndrome after lonafarnib treatment.\r\n<\/a>Ullrich NJ, Kieran MW, Miller DT, Gordon LB, Cho YJ, Silvera VM, Giobbie-Hurder A, Neuberg D, Kleinman ME. <i>Neurology<\/i>. 2013 Jul 30;81(5):427-30. doi: 10.1212\/WNL.0b013e31829d85c0. Epub 2013 Jun 28.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23179651\"><b>Imaging<\/b>\u00a0<b>characteristics<\/b>\u00a0of\u00a0<b>cerebrovascular<\/b>\u00a0<b>arteriopathy<\/b>\u00a0and\u00a0<b>stroke<\/b>\u00a0in Hutchinson-Gilford progeria syndrome.<\/a> Silvera VM, Gordon LB, Orbach DB, Campbell SE, Machan JT, Ullrich NJ.\r\n<i>AJNR Am J Neuroradiol<\/i>. 2013 May;34(5):1091-7. doi: 10.3174\/ajnr.A3341. Epub 2012 Nov 22.<\/p>\r\n<p class=\"desc\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22460337\"><b>Craniofacial abnormalities<\/b>\u00a0in\u00a0<b>Hutchinson<\/b>-Gilford progeria syndrome.\r\n<\/a>Ullrich NJ, Silvera VM, Campbell SE, Gordon LB. <i>AJNR Am J Neuroradiol<\/i>. 2012 Sep;33(8):1512-8. doi: 10.3174\/ajnr.A3088. Epub 2012 Mar 29.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23012407\"><b>Clinical trial<\/b>\u00a0of a\u00a0<b>farnesyltransferase<\/b>\u00a0<b>inhibitor<\/b>\u00a0in\u00a0<b>children<\/b>\u00a0with\u00a0<b>Hutchinson<\/b>-Gilford progeria syndrome.<\/a> Gordon LB, Kleinman ME, Miller DT, Neuberg DS, Giobbie-Hurder A, Gerhard-Herman M, Smoot LB, Gordon CM, Cleveland R, Snyder BD, Fligor B, Bishop WR, Statkevich P, Regen A, Sonis A, Riley S, Ploski C, Correia A, Quinn N, Ullrich NJ, Nazarian A, Liang MG, Huh SY, Schwartzman A, Kieran MW. <i>Proc Natl Acad Sci U S A<\/i>. 2012 Oct 9;109(41):16666-71. doi: 10.1073\/pnas.1202529109. Epub 2012 Sep 24<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22083160\"><b>Mechanisms<\/b>\u00a0of\u00a0<b>premature<\/b>\u00a0<b>vascular<\/b>\u00a0<b>aging<\/b>\u00a0in\u00a0<b>children<\/b>\u00a0with\u00a0<b>Hutchinson<\/b>-Gilford progeria syndrome.<\/a> Gerhard-Herman M, Smoot LB, Wake N, Kieran MW, Kleinman ME, Miller DT, Schwartzman A, Giobbie-Hurder A, Neuberg D, Gordon LB. <i>Hypertension<\/i>. 2012 Jan;59(1):92-7. doi: 10.1161\/HYPERTENSIONAHA.111.180919. Epub 2011 Nov 14.<\/p>\r\n<p class=\"desc\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22752073\"><strong>A\u00a0prospective study\u00a0of\u00a0radiographic\u00a0manifestations\u00a0in Hutchinson-Gilford progeria syndrome.<\/strong>\r\n<\/a>Cleveland RH, Gordon LB, Kleinman ME, Miller DT, Gordon CM, Snyder BD, Nazarian A, Giobbie-Hurder A, Neuberg D, Kieran MW. <i>Pediatr Radiol<\/i>. 2012 Sep;42(9):1089-98. doi: 10.1007\/s00247-012-2423-1. Epub 2012 Jul 1.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21980471\"><b>Low<\/b>\u00a0and\u00a0<b>high<\/b>\u00a0<b>expressing<\/b>\u00a0<b>alleles<\/b>\u00a0of the LMNA gene: implications for laminopathy disease development.<\/a> Rodr\u00edguez S, Eriksson M. <i>PLoS One<\/i>. 2011;6(9):e25472. doi: 10.1371\/journal.pone.0025472. Epub 2011 Sep 29.\r\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21445982\"><b>\r\nHutchinson-Gilford<\/b>\u00a0<b>progeria<\/b>\u00a0is a\u00a0<b>skeletal<\/b>\u00a0dysplasia.<\/a> Gordon CM, Gordon LB, Snyder BD, Nazarian A, Quinn N, Huh S, Giobbie-Hurder A, Neuberg D, Cleveland R, Kleinman M, Miller DT, Kieran MW. <i>J Bone Miner Res<\/i>. 2011 Jul;26(7):1670-9. doi: 10.1002\/jbmr.392.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20798379\"><b>Cardiovascular pathology<\/b>\u00a0in\u00a0<b>Hutchinson<\/b>-Gilford progeria: correlation with the vascular<b>pathology<\/b>\u00a0of aging.<\/a> Olive M, Harten I, Mitchell R, Beers JK, Djabali K, Cao K, Erdos MR, Blair C, Funke B, Smoot L, Gerhard-Herman M, Machan JT, Kutys R, Virmani R, Collins FS, Wight TN, Nabel EG, Gordon LB. <i>Arterioscler Thromb Vasc Biol<\/i>. 2010 Nov;30(11):2301-9. doi: 10.1161\/ATVBAHA.110.209460. Epub 2010 Aug 26.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19236595\"><b>Hutchinson-Gilford<\/b>\u00a0<b>progeria<\/b>\u00a0<b>syndrome<\/b>:\u00a0<b>oral<\/b>\u00a0and craniofacial phenotypes.<\/a> Domingo DL, Trujillo MI, Council SE, Merideth MA, Gordon LB, Wu T, Introne WJ, Gahl WA, Hart TC. <i>Oral<\/i><i>\u00a0<\/i><i>Dis<\/i>. 2009 Apr;15(3):187-95. doi: 10.1111\/j.1601-0825.2009.01521.x. Epub 2009 Feb 19.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18334552\"><b>Targeted<\/b>\u00a0<b>transgenic<\/b>\u00a0<b>expression<\/b>\u00a0of the\u00a0<b>mutation<\/b>\u00a0<b>causing<\/b>\u00a0Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease.<\/a> Sagelius H, Rosengardten Y, Hanif M, Erdos MR, Rozell B, Collins FS, Eriksson M. <i>J Cell Sci<\/i>. 2008 Apr 1;121(Pt 7):969-78. doi: 10.1242\/jcs.022913. Epub 2008 Mar 11.<\/p>\r\n<p class=\"desc\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18708427\"><b>Reversible<\/b>\u00a0<b>phenotype<\/b>\u00a0in a\u00a0<b>mouse<\/b>\u00a0model of Hutchinson-Gilford progeria syndrome.\r\n<\/a>Sagelius H, Rosengardten Y, Schmidt E, Sonnabend C, Rozell B, Eriksson M. <i>J Med Genet<\/i>. 2008 Dec;45(12):794-801. doi: 10.1136\/jmg.2008.060772. Epub 2008 Aug 15.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18256394\"><b>Phenotype<\/b>\u00a0and\u00a0<b>course<\/b>\u00a0of\u00a0<b>Hutchinson<\/b>-Gilford progeria syndrome.<\/a> Merideth MA, Gordon LB, Clauss S, Sachdev V, Smith AC, Perry MB, Brewer CC, Zalewski C, Kim HJ, Solomon B, Brooks BP, Gerber LH, Turner ML, Domingo DL, Hart TC, Graf J, Reynolds JC, Gropman A, Yanovski JA, Gerhard-Herman M, Collins FS, Nabel EG, Cannon RO 3rd, Gahl WA, Introne WJ. <i>N Engl J Med<\/i>. 2008 Feb 7;358(6):592-604. doi: 10.1056\/NEJMoa0706898.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17908771\"><b>New<\/b>\u00a0<b>approaches<\/b>\u00a0to\u00a0<b>progeria<\/b>.<\/a> Kieran MW, Gordon L, Kleinman M. Pediatrics. 2007 Oct;120(4):834-41. Review. Erratum in: <i>Pediatrics<\/i>. 2007 Dec;120(6):1405.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17908770\"><b>Disease progression<\/b>\u00a0in\u00a0<b>Hutchinson-Gilford<\/b>\u00a0progeria syndrome: impact on growth and development.<\/a> Gordon LB, McCarten KM, Giobbie-Hurder A, Machan JT, Campbell SE, Berns SD, Kieran MW. <i>Pediatrics<\/i>. 2007 Oct;120(4):824-33.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15756215\"><b>Reduced<\/b>\u00a0<b>adiponectin<\/b>\u00a0and\u00a0<b>HDL cholesterol<\/b>\u00a0without\u00a0<b>elevated<\/b>\u00a0<b>C-reactive protein<\/b>: clues to the biology of premature atherosclerosis in Hutchinson-Gilford Progeria Syndrome.<\/a> Gordon LB, Harten IA, Patti ME, Lichtenstein AH. <i>J Pediatr<\/i>. 2005 Mar;146(3):336-41.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16129833\"><b>Inhibiting<\/b>\u00a0<b>farnesylation<\/b>\u00a0of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford\u00a0<b>progeria<\/b>\u00a0syndrome.<\/a> Capell BC, Erdos MR, Madigan JP, Fiordalisi JJ, Varga R, Conneely KN, Gordon LB, Der CJ, Cox AD, Collins FS. <i>Proc Natl Acad Sci U S A<\/i>. 2005 Sep 6;102(36):12879-84. Epub 2005 Aug 29<\/p>\r\n<p class=\"details\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15184648\"><b>Accumulation<\/b>\u00a0of\u00a0<b>mutant<\/b>\u00a0<b>lamin A<\/b>\u00a0<b>causes<\/b>\u00a0progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome.<\/a> Goldman RD, Shumaker DK, Erdos MR, Eriksson M, Goldman AE, Gordon LB, Gruenbaum Y, Khuon S, Mendez M, Varga R, Collins FS. <i>Proc Natl Acad Sci U S A<\/i>. 2004 Jun 15;101(24):8963-8. Epub 2004 Jun 7.<\/p>\r\n<strong>Books and Documents<\/strong>\r\n\r\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20301300\" target=\"_blank\" rel=\"noopener noreferrer\">Hutchinson-Gilford Progeria Syndrome.<\/a>\u00a0 Gordon LB, Brown WT, Collins FS. In: Pagon RA, Bird TD, Dolan CR, Stephens K, editors. GeneReviews [Internet]. Seattle (WA): University of Washington, Seattle; 1993-.\r\n2003 Dec 12 [updated 2011 Jan 06].\r\n\r\nThe Premature Aging Syndrome Hutchinson-Gilford Progeria: Insights Into Normal Aging. Gordon, Leslie. Chapter in the 7th edition of <em>Brocklehurst\u2019s Textbook of Geriatric Medicine and Gerontology<\/em>. Copyright: 2010.\r\n\r\n<em>LMNA<\/em> and the Hutchinson-Gilford Progeria Syndrome and Associated Laminopathies. Gordon LB, Brown WT, Rothman FG. \u00a0In C. J. Epstein, R. P. Erickson, A. Wynshaw-Boris (Eds.)<em> Inborn Errors of Development: The molecular basis of clinical disorders of morphogenesis<\/em> (2<sup>nd<\/sup> ed.). New York, NY: Oxford University Press. 2008 139: 1219-1229.[\/vc_column_text][vc_column_text]Sam passed away on January 10, 2014, leaving a legacy of inspiration that now drives PRF and its supporters to continue the quest for a cure, with more determination than ever. <a href=\"https:\/\/www.progeriaresearch.org\/sam-berns-102396-0110141.html\">Click here<\/a> to learn more about this remarkable young man.[\/vc_column_text][vc_column_text]Together with caring, dedicated board members and other generous volunteers, The Progeria Research Foundation was created to raise awareness, educate and help the families, their doctors, researchers and the general public about Hutchinson-Gilford Progeria Syndrome. In addition, PRF funds medical research and runs research-related programs specifically aimed at finding the cause*, treatments, and cure for this syndrome.[\/vc_column_text][vc_column_text]Since its inception, PRF has benefited from the leadership of Attorney Audrey Gordon, Sam's aunt, who serves as the organization's President and Executive Director.[\/vc_column_text][vc_column_text]<strong>Did you know?<\/strong>\r\n\r\nWith the exception of our staff, everyone involved with PRF is a volunteer! Our Board of Directors, Clerk, Treasurer, committee members, translators, fund-raisers, etc. all devote their time, energy and talents to furthering our mission without pay. As a result, our administrative costs are very low. This leaves more money to devote to medical research and raising public awareness, which ultimately lead to finding a cure for Progeria.[\/vc_column_text][vc_column_text css=\".vc_custom_1508790933490{background-color: #ffffff !important;}\"]\r\n<p class=\"\">Leslie B. Gordon, MD, PhD, is PRF's Medical Director. She is also the Principal Investigator of PRF's research-related programs: The PRF International Registry, Cell & Tissue Bank, Medical & Research Database, and Diagnostics Testing Program, and co-author on the historic Progeria gene finding and treatment discovery*.<\/p>\r\n[\/vc_column_text][vc_column_text css=\".vc_custom_1488054553154{background-color: #ffffff !important;}\"]\r\n<p class=\"\">* Thanks to PRF's efforts, in April 2003 PRF and the National Institutes of Health announced that <a href=\"https:\/\/www.progeriaresearch.org\/identification_of_gene_gives_hope_to_children_with_progeria.html\">the cause of Progeria, a mutation in the LMNA gene, was found<\/a>, and in September 2012, <a href=\"https:\/\/www.progeriaresearch.org\/first-ever-progeria-treatment.html\">the first-ever treatment was discovered.<\/a><\/p>\r\n[\/vc_column_text][vc_column_text css=\".vc_custom_1488054565202{background-color: #ffffff !important;}\"]There is much work to be done and little resources with which to do so. We cannot do it alone. With your support, the cure will be discovered for these wonderful children.[\/vc_column_text][vc_column_text css=\".vc_custom_1488054579010{background-color: #ffffff !important;}\"]Together, we <em>WILL<\/em> find the cure.[\/vc_column_text][\/vc_column][\/vc_row]\t\t","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-788","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Database | The Progeria Research Foundation<\/title>\n<meta name=\"description\" content=\"As part of our continued efforts in finding the cure, PRF collects the medical records for children with Progeria from all over the world.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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