{"id":2054,"date":"2011-05-16T12:41:18","date_gmt":"2011-05-16T12:41:18","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?p=2054"},"modified":"2020-12-10T17:52:21","modified_gmt":"2020-12-10T22:52:21","slug":"prf-funded-study-identifies-rapamycin-as-possible-treatment-for-progeria","status":"publish","type":"post","link":"https:\/\/www.progeriaresearch.org\/ar\/2011\/05\/16\/prf-funded-study-identifies-rapamycin-as-possible-treatment-for-progeria\/","title":{"rendered":"\u062f\u0631\u0627\u0633\u0629 \u0645\u0645\u0648\u0644\u0629 \u0645\u0646 PRF \u062a\u062d\u062f\u062f \u0639\u0642\u0627\u0631 \u0631\u0627\u0628\u0627\u0645\u064a\u0633\u064a\u0646 \u0643\u0639\u0644\u0627\u062c \u0645\u062d\u062a\u0645\u0644 \u0644\u0645\u0631\u0636 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629"},"content":{"rendered":"<p>[et_pb_section fb_built=&quot;1&quot; _builder_version=&quot;3.22&quot;][et_pb_row _builder_version=&quot;3.25&quot; background_size=&quot;initial&quot; background_position=&quot;top_left&quot; background_repeat=&quot;repeat&quot;][et_pb_column type=&quot;4_4&quot; _builder_version=&quot;3.25&quot; custom_padding=&quot;|||&quot; custom_padding__hover=&quot;|||&quot;][et_pb_text _builder_version=&quot;4.6.5&quot; background_size=&quot;initial&quot; background_position=&quot;top_left&quot; background_repeat=&quot;repeat&quot; hover_enabled=&quot;0&quot; sticky_enabled=&quot;0&quot;]<\/p>\n<p>\u0646\u0634\u0631 \u0628\u0627\u062d\u062b\u0648\u0646 \u0641\u064a \u0627\u0644\u0645\u0639\u0627\u0647\u062f \u0627\u0644\u0648\u0637\u0646\u064a\u0629 \u0644\u0644\u0635\u062d\u0629 \u0648\u0645\u0633\u062a\u0634\u0641\u0649 \u0645\u0627\u0633\u0627\u062a\u0634\u0648\u0633\u062a\u0633 \u0627\u0644\u0639\u0627\u0645 \u0641\u064a \u0628\u0648\u0633\u0637\u0646 \u0628\u0648\u0644\u0627\u064a\u0629 \u0645\u0627\u0633\u0627\u062a\u0634\u0648\u0633\u062a\u0633 \u062f\u0631\u0627\u0633\u0629 \u062c\u062f\u064a\u062f\u0629 \u0627\u0644\u064a\u0648\u0645 \u0641\u064a <em>\u0627\u0644\u0639\u0644\u0648\u0645 \u0648\u0627\u0644\u0637\u0628 \u0627\u0644\u0627\u0646\u062a\u0642\u0627\u0644\u064a<\/em> \u0648\u0647\u0648 \u0645\u0627 \u0642\u062f \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u0625\u064a\u062c\u0627\u062f \u0639\u0644\u0627\u062c \u062c\u062f\u064a\u062f \u0644\u0644\u0623\u0637\u0641\u0627\u0644 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629.*<\/p>\n<div id=\"secondary-header-content\">\n<p><em>\u0631\u0627\u0628\u0627\u0645\u064a\u0633\u064a\u0646<\/em> \u0647\u0648 \u062f\u0648\u0627\u0621 \u0645\u0639\u062a\u0645\u062f \u0645\u0646 \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 \u0648\u0642\u062f \u062b\u0628\u062a 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\u0648\u064a\u0637\u064a\u0644 \u0639\u0645\u0631 \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629. \u062a\u0642\u062f\u0645 \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0623\u0648\u0644 \u062f\u0644\u064a\u0644 \u0639\u0644\u0649 \u0623\u0646 \u0627\u0644\u0631\u0627\u0628\u0627\u0645\u064a\u0633\u064a\u0646 \u0642\u062f \u064a\u0643\u0648\u0646 \u0642\u0627\u062f\u0631\u064b\u0627 \u0639\u0644\u0649 \u062a\u0642\u0644\u064a\u0644 <img loading=\"lazy\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/web.archive.org\/web\/20170216095136im_\/https:\/\/www.progeriaresearch.org\/assets\/images\/medical_images\/Cao-with-caption.jpg\" alt=\"\" width=\"200\" height=\"169\" \/>\u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0636\u0627\u0631\u0629 \u0644\u0644\u0628\u0631\u0648\u062c\u064a\u0631\u064a\u0646 \u0639\u0644\u0649 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629.<\/p>\n<p>\u0647\u0646\u0627\u0643 \u062a\u063a\u0637\u064a\u0629 \u0625\u0639\u0644\u0627\u0645\u064a\u0629 \u0647\u0627\u0626\u0644\u0629 \u0644\u0647\u0630\u0627 \u0627\u0644\u0645\u0648\u0636\u0648\u0639! \u0627\u0646\u0642\u0631 \u0623\u062f\u0646\u0627\u0647 \u0644\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0631\u0648\u0627\u0628\u0637 \u0644\u0644\u0642\u0635\u0635 \u0627\u0644\u0625\u0639\u0644\u0627\u0645\u064a\u0629:<\/p>\n<p><strong><a href=\"https:\/\/blogs.wsj.com\/health\/2011\/06\/29\/a-new-drug-for-rare-fatal-childhood-disease\/\" target=\"_blank\" rel=\"noopener noreferrer\">\u0645\u062f\u0648\u0646\u0629 \u0648\u0648\u0644 \u0633\u062a\u0631\u064a\u062a \u062c\u0648\u0631\u0646\u0627\u0644 \u0627\u0644\u0635\u062d\u064a\u0629<\/a><\/strong><\/p>\n<p><strong><a href=\"https:\/\/health.usnews.com\/health-news\/family-health\/boomer-health\/articles\/2011\/06\/29\/organ-transplant-drug-might-treat-rapid-aging-disease-in-kids\" target=\"_blank\" rel=\"noopener noreferrer\">\u0623\u062e\u0628\u0627\u0631 \u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629 \u0648\u0627\u0644\u062a\u0642\u0631\u064a\u0631 \u0627\u0644\u0639\u0627\u0644\u0645\u064a<\/a><\/strong><\/p>\n<p><strong><a href=\"https:\/\/stm.sciencemag.org\/content\/3\/89\/89ra58\" target=\"_blank\" rel=\"noopener noreferrer\">\u0645\u062c\u0644\u0629 \u0627\u0644\u0639\u0644\u0648\u0645<\/a><\/strong><\/p>\n<p><strong><a href=\"https:\/\/www.boston.com\/lifestyle\/health\/articles\/2011\/06\/30\/childrens_hospital_plans_trial_of_drug_for_aging_disorder\/?p1=News_links\" target=\"_blank\" rel=\"noopener noreferrer\">\u0628\u0648\u0633\u0637\u0646 \u062c\u0644\u0648\u0628<\/a><\/strong><\/p>\n<p><strong>\u0633\u064a \u0625\u0646 \u0625\u0646<\/strong> (\u0627\u0644\u0631\u0627\u0628\u0637 \u0644\u0645 \u064a\u0639\u062f \u0646\u0634\u0637\u0627)<strong><br \/><\/strong><\/p>\n<p>\u0633\u0639\u062f\u062a \u0645\u0624\u0633\u0633\u0629 \u0623\u0628\u062d\u0627\u062b \u0645\u0631\u0636 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0628\u062a\u0648\u0641\u064a\u0631 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0644\u0647\u0630\u0627 \u0627\u0644\u0645\u0634\u0631\u0648\u0639 \u0645\u0646 <a href=\"https:\/\/www.progeriaresearch.org\/ar\/cell-and-tissue-bank\/\">\u0628\u0646\u0643 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0648\u0627\u0644\u0623\u0646\u0633\u062c\u0629 PRF<\/a>\u060c \u0648\u0627\u0644\u0645\u0633\u0627\u0639\u062f\u0629 \u0641\u064a \u062a\u0645\u0648\u064a\u0644 \u0627\u0644\u0628\u062d\u062b \u0645\u0646 \u062e\u0644\u0627\u0644 <a href=\"https:\/\/www.progeriaresearch.org\/ar\/grants-funded\/\">\u0628\u0631\u0646\u0627\u0645\u062c \u0627\u0644\u0645\u0646\u062d<\/a>.<\/p>\n<p>\u062a\u0638\u0647\u0631 \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062c\u062f\u064a\u062f\u0629 \u0627\u0644\u0645\u062b\u064a\u0631\u0629 \u0627\u0644\u0648\u062a\u064a\u0631\u0629 \u0627\u0644\u0645\u0630\u0647\u0644\u0629 \u0644\u0623\u0628\u062d\u0627\u062b \u0645\u0631\u0636 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629\u060c \u0645\u0639 \u062a\u0648\u0641\u064a\u0631 \u0627\u0644\u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u0631\u0624\u0649 \u062d\u0648\u0644 \u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u062a\u064a \u062a\u0624\u062b\u0631 \u0639\u0644\u064a\u0646\u0627 \u062c\u0645\u064a\u0639\u064b\u0627.<\/p>\n<p>*&quot;\u064a\u0639\u0643\u0633 \u0627\u0644\u0631\u0627\u0628\u0627\u0645\u064a\u0633\u064a\u0646 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u0638\u0627\u0647\u0631\u064a \u0627\u0644\u062e\u0644\u0648\u064a \u0648\u064a\u0639\u0632\u0632 \u0625\u0632\u0627\u0644\u0629 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0645\u062a\u062d\u0648\u0631 \u0641\u064a \u062e\u0644\u0627\u064a\u0627 \u0647\u062a\u0634\u064a\u0646\u0633\u0648\u0646 \u062c\u064a\u0644\u0641\u0648\u0631\u062f \u0628\u0631\u0648\u062c\u064a\u0631\u064a\u0627&quot;<br \/>\u0643\u0627\u0646 \u0643\u0627\u0648\u060c \u062c\u0648\u0646 \u062c. \u062c\u0631\u0627\u0632\u064a\u0648\u062a\u0648\u060c \u0633\u064a\u0633\u064a\u0644\u064a\u0627 \u062f. \u0628\u0644\u064a\u0631\u060c \u062c\u0648\u0632\u064a\u0641 \u0631. \u0645\u0627\u0632\u0648\u0644\u064a\u060c \u0645\u0627\u064a\u0643\u0644 \u0631. \u0625\u0631\u062f\u0648\u0633\u060c \u062f\u064a\u0645\u062a\u0631\u064a \u0643\u0631\u064a\u0646\u0643\u060c \u0641\u0631\u0627\u0646\u0633\u064a\u0633 \u0633. \u0643\u0648\u0644\u064a\u0646\u0632<br \/>29 \u064a\u0648\u0646\u064a\u0648 2011 \u0627\u0644\u0645\u062c\u0644\u062f 3 \u0627\u0644\u0639\u062f\u062f 89<br \/>\u0646\u0633\u062e\u0629 \u0625\u0644\u0643\u062a\u0631\u0648\u0646\u064a\u0629 \u0642\u0628\u0644 \u0627\u0644\u0637\u0628\u0627\u0639\u0629<\/p>\n<\/div>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;3.22&#8243;][et_pb_row _builder_version=&#8221;3.25&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.6.5&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;] Researchers at the National Institutes of Health and Massachusetts General Hospital in Boston, MA published a new study today in Science, Translational Medicine that may lead to a new drug treatment for children with Progeria.* Rapamycin is an [&hellip;]<\/p>","protected":false},"author":1,"featured_media":11636,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"<p>[vc_custom_heading text=\"PRF-funded study Identifies Rapamycin as Possible Treatment for Progeria\" font_container=\"tag:h1|text_align:left\" use_theme_fonts=\"yes\"]<\/p><div id=\"secondary-header-content\"><p>Researchers at the National Institutes of Health and Massachusetts General Hospital in Boston, MA published a new study today in <em>Science, Translational Medicine<\/em> that may lead to a new drug treatment for children with Progeria.*<\/p><p><em>Rapamycin<\/em> is an FDA approved drug that has previously been shown to extend the lives of non-progeria mouse models. This new study demonstrates that rapamycin decreases the amount of the disease-causing protein progerin by 50%, improves the abnormal nuclear shape, and extends the lifespan of progeria cells. This study provides the first evidence that rapamycin may be able to decrease <img class=\"alignleft\" src=\"https:\/\/web.archive.org\/web\/20170216095136im_\/https:\/\/www.progeriaresearch.org\/assets\/images\/medical_images\/Cao-with-caption.jpg\" alt=\"\" width=\"200\" height=\"169\" \/>progerin's damaging effects in children with progeria.<\/p><p>There is tremendous media coverage on this! Click below for links to media stories:<\/p><p><strong><a href=\"https:\/\/blogs.wsj.com\/health\/2011\/06\/29\/a-new-drug-for-rare-fatal-childhood-disease\/\" target=\"_blank\" rel=\"noopener noreferrer\">Wall Street Journal Health Blog<\/a><\/strong><\/p><p><strong><a href=\"https:\/\/health.usnews.com\/health-news\/family-health\/boomer-health\/articles\/2011\/06\/29\/organ-transplant-drug-might-treat-rapid-aging-disease-in-kids\" target=\"_blank\" rel=\"noopener noreferrer\">US News and World Report<\/a><\/strong><\/p><p><strong><a href=\"https:\/\/news.sciencemag.org\/sciencenow\/2011\/06\/new-drug-hope-for-aging-kids.html?ref=hp\" target=\"_blank\" rel=\"noopener noreferrer\">Science Magazine<\/a><\/strong><\/p><p><strong><a href=\"https:\/\/www.boston.com\/lifestyle\/health\/articles\/2011\/06\/30\/childrens_hospital_plans_trial_of_drug_for_aging_disorder\/?p1=News_links\" target=\"_blank\" rel=\"noopener noreferrer\">Boston Globe<\/a><\/strong><\/p><p><strong><a href=\"https:\/\/www.cnn.com\/2011\/HEALTH\/07\/01\/progeria.treatment.aging.collins\/index.html\" target=\"_blank\" rel=\"noopener noreferrer\">CNN<\/a><br \/><\/strong><\/p><p>The Progeria Research Foundation was delighted to provide cells for this project from the <a href=\"https:\/\/www.progeriaresearch.org\/cell-and-tissue-bank\/\">PRF Cell & Tissue Bank<\/a>, and help fund the research through our <a href=\"https:\/\/www.progeriaresearch.org\/grants-funded\/\">grants program<\/a>.<\/p><p>This exciting new study demonstrates the remarkable pace of progeria research, while providing further insight into the aging process that affects us all.<\/p><p>*\"Rapamycin Reverses Cellular Phenotypes and Enhances Mutant Protein Clearance in Hutchinson-Gilford Progeria Cells\"<br \/>Kan Cao, John J. Graziotto, Cecilia D. Blair, Joseph R. Mazzulli, Michael R. Erdos, Dimitri Krainc, Francis S. Collins<br \/>29 June 2011 Vol 3 Issue 89<br \/>Epub ahead of print<\/p><\/div>","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-2054","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>PRF-funded study Identifies Rapamycin as Possible Treatment for Progeria - The Progeria Research Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.progeriaresearch.org\/ar\/2011\/05\/16\/prf-funded-study-identifies-rapamycin-as-possible-treatment-for-progeria\/\" \/>\n<meta property=\"og:locale\" content=\"ar_AR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PRF-funded study Identifies Rapamycin as Possible Treatment for Progeria - The Progeria Research Foundation\" \/>\n<meta property=\"og:description\" content=\"[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;3.22&#8243;][et_pb_row _builder_version=&#8221;3.25&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.6.5&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;] Researchers at the National Institutes of Health and Massachusetts General Hospital in Boston, MA published a new study today in Science, Translational Medicine that may lead to a new drug treatment for children with Progeria.* Rapamycin is an [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.progeriaresearch.org\/ar\/2011\/05\/16\/prf-funded-study-identifies-rapamycin-as-possible-treatment-for-progeria\/\" \/>\n<meta property=\"og:site_name\" content=\"The Progeria Research Foundation\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ProgeriaResearch\/\" \/>\n<meta property=\"article:published_time\" content=\"2011-05-16T12:41:18+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-12-10T22:52:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2006\/05\/cells-e1607545663671.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"733\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"gravoc\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" 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