{"id":12401,"date":"2021-03-11T21:08:40","date_gmt":"2021-03-12T02:08:40","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?p=12401"},"modified":"2022-11-14T17:12:14","modified_gmt":"2022-11-14T22:12:14","slug":"exciting-breakthroughs-in-rna-therapeutics-for-progeria","status":"publish","type":"post","link":"https:\/\/www.progeriaresearch.org\/bn\/2021\/03\/11\/exciting-breakthroughs-in-rna-therapeutics-for-progeria\/","title":{"rendered":"\u09aa\u09cd\u09b0\u09cb\u099c\u09c7\u09b0\u09bf\u09af\u09bc\u09be\u09b0 \u099c\u09a8\u09cd\u09af \u0986\u09b0\u098f\u09a8\u098f \u09a5\u09c7\u09b0\u09be\u09aa\u09bf\u0989\u099f\u09bf\u0995\u09b8\u09c7 \u0989\u09a4\u09cd\u09a4\u09c7\u099c\u09a8\u09be\u09aa\u09c2\u09b0\u09cd\u09a3 \u09b8\u09be\u09ab\u09b2\u09cd\u09af!"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;section&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_row admin_label=&#8221;row&#8221; _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.18.1&#8243; _module_preset=&#8221;default&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-12360 alignnone size-full aligncenter\" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2021\/03\/Carlos.jpg\" alt=\"\" width=\"150\" height=\"300\" \/><\/p>\n<p>\u0986\u09ae\u09b0\u09be \u09a5\u09c7\u0995\u09c7 \u09ab\u09b2\u09be\u09ab\u09b2 \u09b6\u09c7\u09af\u09bc\u09be\u09b0 \u0995\u09b0\u09be\u09b0 \u099c\u09a8\u09cd\u09af 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\u09ae\u09c7\u09a1\u09bf\u0995\u09cd\u09af\u09be\u09b2 \u09a1\u09bf\u09b0\u09c7\u0995\u09cd\u099f\u09b0, \u09a1\u0983 \u09b2\u09c7\u09b8\u09b2\u09bf \u0997\u09b0\u09cd\u09a1\u09a8 \u09b8\u09b9-\u09b2\u09c7\u0996\u0995\u0964<\/p>\n<p>\u09aa\u09cd\u09b0\u09cb\u099c\u09c7\u09b0\u09bf\u09a8 \u09b9\u09b2 \u09aa\u09cd\u09b0\u09cb\u099c\u09c7\u09b0\u09bf\u09af\u09bc\u09be\u09b0 \u09b0\u09cb\u0997 \u09b8\u09c3\u09b7\u09cd\u099f\u09bf\u0995\u09be\u09b0\u09c0 \u09aa\u09cd\u09b0\u09cb\u099f\u09bf\u09a8\u0964 \u0986\u09b0\u098f\u09a8\u098f \u09a5\u09c7\u09b0\u09be\u09aa\u09bf\u0997\u09c1\u09b2\u09bf \u0986\u09b0\u098f\u09a8\u098f \u09b8\u09cd\u09a4\u09b0\u09c7 \u098f\u09b0 \u0989\u09a4\u09cd\u09aa\u09be\u09a6\u09a8\u0995\u09c7 \u0985\u09ac\u09b0\u09c1\u09a6\u09cd\u09a7 \u0995\u09b0\u09c7 \u09aa\u09cd\u09b0\u09cb\u099c\u09c7\u09b0\u09bf\u09a8 \u0989\u09a4\u09cd\u09aa\u09be\u09a6\u09a8 \u0995\u09b0\u09be\u09b0 \u099c\u09a8\u09cd\u09af \u09b6\u09b0\u09c0\u09b0\u09c7\u09b0 \u0995\u09cd\u09b7\u09ae\u09a4\u09be\u09a4\u09c7 \u09b9\u09b8\u09cd\u09a4\u0995\u09cd\u09b7\u09c7\u09aa \u0995\u09b0\u09c7\u0964 \u098f\u09b0 \u09ae\u09be\u09a8\u09c7 \u09b9\u09b2<strong> \u099a\u09bf\u0995\u09bf\u09a4\u09cd\u09b8\u09be \u0985\u09a7\u09bf\u0995\u09be\u0982\u09b6 \u09a5\u09c7\u09b0\u09be\u09aa\u09bf\u09b0 \u09a4\u09c1\u09b2\u09a8\u09be\u09af\u09bc \u0986\u09b0\u09cb \u09a8\u09bf\u09b0\u09cd\u09a6\u09bf\u09b7\u09cd\u099f<\/strong> \u09af\u09c7 \u09aa\u09cd\u09b0\u09cb\u099f\u09bf\u09a8 \u09b8\u09cd\u09a4\u09b0\u09c7 \u09b2\u0995\u09cd\u09b7\u09cd\u09af progerin.<\/p>\n<p>\u09af\u09a6\u09bf\u0993 \u09aa\u09cd\u09b0\u09a4\u09bf\u099f\u09bf \u0997\u09ac\u09c7\u09b7\u09a3\u09be\u09af\u09bc \u098f\u0995\u099f\u09bf \u09ad\u09bf\u09a8\u09cd\u09a8 \u0993\u09b7\u09c1\u09a7 \u09b8\u09b0\u09ac\u09b0\u09be\u09b9 \u09ac\u09cd\u09af\u09ac\u09b8\u09cd\u09a5\u09be \u09ac\u09cd\u09af\u09ac\u09b9\u09be\u09b0 \u0995\u09b0\u09be \u09b9\u09af\u09bc\u09c7\u099b\u09c7, \u0989\u09ad\u09af\u09bc \u0997\u09ac\u09c7\u09b7\u09a3\u09be\u09af\u09bc \u098f\u0995\u0987 \u09ae\u09cc\u09b2\u09bf\u0995 \u099a\u09bf\u0995\u09bf\u09a4\u09cd\u09b8\u09be \u0995\u09cc\u09b6\u09b2 \u09b2\u0995\u09cd\u09b7\u09cd\u09af \u0995\u09b0\u09be \u09b9\u09af\u09bc\u09c7\u099b\u09c7, \u0985\u09b8\u09cd\u09ac\u09be\u09ad\u09be\u09ac\u09bf\u0995 \u09aa\u09cd\u09b0\u09cb\u099f\u09bf\u09a8, \u09aa\u09cd\u09b0\u09cb\u099c\u09c7\u09b0\u09bf\u09a8\u09c7\u09b0 \u099c\u09a8\u09cd\u09af \u0986\u09b0\u098f\u09a8\u098f \u0995\u09cb\u09a1\u09bf\u0982 \u0989\u09ce\u09aa\u09be\u09a6\u09a8\u09c7 \u09ac\u09be\u09a7\u09be \u09a6\u09c7\u09af\u09bc\u0964 \u0989\u09ad\u09af\u09bc\u0987 \u09a8\u09cd\u09af\u09be\u09b6\u09a8\u09be\u09b2 \u0987\u09a8\u09b8\u09cd\u099f\u09bf\u099f\u09bf\u0989\u099f \u0985\u09ab \u09b9\u09c7\u09b2\u09a5 (\u098f\u09a8\u0986\u0987\u098f\u0987\u099a) \u098f\u09b0 \u0997\u09ac\u09c7\u09b7\u0995\u09a6\u09c7\u09b0 \u09a8\u09c7\u09a4\u09c3\u09a4\u09cd\u09ac\u09c7 \u099b\u09bf\u09b2 \u098f\u09ac\u0982 \u0986\u099c \u099c\u09be\u09b0\u09cd\u09a8\u09be\u09b2\u09c7 \u09aa\u09cd\u09b0\u0995\u09be\u09b6\u09bf\u09a4 \u09b9\u09af\u09bc\u09c7\u099b\u09bf\u09b2 <em>\u09aa\u09cd\u09b0\u0995\u09c3\u09a4\u09bf\u09b0 \u0994\u09b7\u09a7<\/em>.<\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41591-021-01274-0\">\u098f\u0995 \u0997\u09ac\u09c7\u09b7\u09a3\u09be<\/a>, \u09ab\u09cd\u09b0\u09be\u09a8\u09cd\u09b8\u09bf\u09b8 \u0995\u09b2\u09bf\u09a8\u09cd\u09b8, \u098f\u09ae\u09a1\u09bf, \u09aa\u09bf\u098f\u0987\u099a\u09a1\u09bf, \u098f\u09a8\u0986\u0987\u098f\u0987\u099a-\u098f\u09b0 \u09aa\u09b0\u09bf\u099a\u09be\u09b2\u0995\u09c7\u09b0 \u09a8\u09c7\u09a4\u09c3\u09a4\u09cd\u09ac\u09c7 \u09a6\u09c7\u0996\u09bf\u09af\u09bc\u09c7\u099b\u09c7\u09a8 \u09af\u09c7 SRP2001 r \u09a8\u09be\u09ae\u0995 \u0993\u09b7\u09c1\u09a7 \u09a6\u09bf\u09af\u09bc\u09c7 \u09aa\u09cd\u09b0\u09cb\u099c\u09c7\u09b0\u09bf\u09af\u09bc\u09be \u0987\u0981\u09a6\u09c1\u09b0\u09c7\u09b0 \u099a\u09bf\u0995\u09bf\u09a4\u09cd\u09b8\u09be \u0995\u09b0\u09be<strong>\u0995\u09cd\u09b7\u09a4\u09bf\u0995\u09be\u09b0\u0995 progerin mRNA \u098f\u09ac\u0982 \u09ae\u09b9\u09be\u09a7\u09ae\u09a8\u09c0\u09a4\u09c7 \u09aa\u09cd\u09b0\u09cb\u099f\u09bf\u09a8 \u098f\u0995\u09cd\u09b8\u09aa\u09cd\u09b0\u09c7\u09b6\u09a8 \u09b6\u09bf\u0995\u09cd\u09b7\u09bf\u09a4<\/strong>, \u09b6\u09b0\u09c0\u09b0\u09c7\u09b0 \u09aa\u09cd\u09b0\u09a7\u09be\u09a8 \u09a7\u09ae\u09a8\u09c0, \u09b8\u09c7\u0987\u09b8\u09be\u09a5\u09c7 \u0985\u09a8\u09cd\u09af\u09be\u09a8\u09cd\u09af \u099f\u09bf\u09b8\u09cd\u09af\u09c1\u09a4\u09c7\u0964 \u0985\u09a7\u09cd\u09af\u09af\u09bc\u09a8\u09c7\u09b0 \u09b6\u09c7\u09b7\u09c7, \u09ae\u09b9\u09be\u09a7\u09ae\u09a8\u09c0 \u09aa\u09cd\u09b0\u09be\u099a\u09c0\u09b0 \u0986\u09b0\u0993 \u09b6\u0995\u09cd\u09a4\u09bf\u09b6\u09be\u09b2\u09c0 \u099b\u09bf\u09b2 \u098f\u09ac\u0982 \u0987\u0981\u09a6\u09c1\u09b0 \u098f\u0995\u099f\u09bf \u09aa\u09cd\u09b0\u09a6\u09b0\u09cd\u09b6\u09a8 \u0995\u09b0\u09c7\u099b\u09bf\u09b2 <strong>60% \u098f\u09b0 \u09ac\u09c7\u09b6\u09bf \u09ac\u09c7\u0981\u099a\u09c7 \u09a5\u09be\u0995\u09be<\/strong>.<\/p>\n<p>&quot;\u098f\u0995\u099f\u09bf \u09b2\u0995\u09cd\u09b7\u09cd\u09af\u09af\u09c1\u0995\u09cd\u09a4 \u0986\u09b0\u098f\u09a8\u098f-\u09a5\u09c7\u09b0\u09be\u09aa\u09bf \u098f\u0995\u099f\u09bf \u09aa\u09cd\u09b0\u09be\u09a3\u09c0 \u09ae\u09a1\u09c7\u09b2\u09c7 \u098f\u0987 \u09a7\u09b0\u09a8\u09c7\u09b0 \u0989\u09b2\u09cd\u09b2\u09c7\u0996\u09af\u09cb\u0997\u09cd\u09af \u09ab\u09b2\u09be\u09ab\u09b2 \u09aa\u09cd\u09b0\u09a6\u09b0\u09cd\u09b6\u09a8 \u0995\u09b0\u09be \u0986\u09ae\u09be\u0995\u09c7 \u0986\u09b6\u09be \u09a6\u09c7\u09af\u09bc \u09af\u09c7 \u098f\u099f\u09bf \u09aa\u09cd\u09b0\u09cb\u099c\u09c7\u09b0\u09bf\u09af\u09bc\u09be\u09b0 \u099a\u09bf\u0995\u09bf\u09a4\u09cd\u09b8\u09be\u09b0 \u099c\u09a8\u09cd\u09af \u098f\u0995\u099f\u09bf \u09ac\u09a1\u09bc 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\u09aa\u09cd\u09b0\u09cb\u099c\u09c7\u09b0\u09bf\u09af\u09bc\u09be \u09a5\u09c7\u09b0\u09be\u09aa\u09bf\u0989\u099f\u09bf\u0995\u09b8\u09c7\u09b0 \u0995\u09cd\u09b7\u09c7\u09a4\u09cd\u09b0\u09c7,\u201d \u09aa\u09bf\u0986\u09b0\u098f\u09ab \u09ae\u09c7\u09a1\u09bf\u0995\u09c7\u09b2 \u09a1\u09bf\u09b0\u09c7\u0995\u09cd\u099f\u09b0 \u09a1\u0983 \u09b2\u09c7\u09b8\u09b2\u09bf \u0997\u09b0\u09cd\u09a1\u09a8 \u09ac\u09b2\u09c7\u099b\u09c7\u09a8\u0964 \u201c\u09aa\u09cd\u09b0\u099c\u09c7\u09b0\u09bf\u09af\u09bc\u09be\u09af\u09bc \u0986\u0995\u09cd\u09b0\u09be\u09a8\u09cd\u09a4 \u09b6\u09bf\u09b6\u09c1\u09a6\u09c7\u09b0 \u099c\u09a8\u09cd\u09af \u0986\u09b0\u098f\u09a8\u098f \u09a5\u09c7\u09b0\u09be\u09aa\u09bf\u09b0 \u0985\u0997\u09cd\u09b0\u0997\u09a4\u09bf\u09b0 \u099c\u09a8\u09cd\u09af \u098f\u0987 \u0989\u099c\u09cd\u099c\u09cd\u09ac\u09b2 \u0997\u09ac\u09c7\u09b7\u09a3\u09be \u0997\u09cb\u09b7\u09cd\u09a0\u09c0\u09b0 \u09b8\u09be\u09a5\u09c7 \u0995\u09be\u099c \u0995\u09b0\u09a4\u09c7 \u09aa\u09c7\u09b0\u09c7 \u0986\u09ae\u09bf \u09b0\u09cb\u09ae\u09be\u099e\u09cd\u099a\u09bf\u09a4 \u09b9\u09af\u09bc\u09c7\u099b\u09bf\u0964 \u0989\u09ad\u09af\u09bc\u0987 \u0989\u09a4\u09cd\u09a4\u09c7\u099c\u09a8\u09be\u09aa\u09c2\u09b0\u09cd\u09a3 \u09aa\u09cd\u09b0\u09c1\u09ab-\u0985\u09ab-\u09aa\u09cd\u09b0\u09bf\u09a8\u09cd\u09b8\u09bf\u09aa\u09b2 \u0985\u09a7\u09cd\u09af\u09af\u09bc\u09a8, \u098f\u09ac\u0982 <strong>PRF \u0995\u09cd\u09b2\u09bf\u09a8\u09bf\u0995\u09be\u09b2 \u099f\u09cd\u09b0\u09be\u09af\u09bc\u09be\u09b2\u09c7\u09b0 \u09a6\u09bf\u0995\u09c7 \u098f\u0997\u09bf\u09af\u09bc\u09c7 \u09af\u09c7\u09a4\u09c7 \u0989\u09a4\u09cd\u09a4\u09c7\u099c\u09bf\u09a4<\/strong> \u09af\u09c7 \u098f\u0987 \u099a\u09bf\u0995\u09bf\u09a4\u09cd\u09b8\u09be \u0995\u09cc\u09b6\u09b2 \u09aa\u09cd\u09b0\u09af\u09bc\u09cb\u0997.<\/p>\n<p>&nbsp;<\/p>\n<p>\u2014<\/p>\n<p>Erdos, MR, Cabral, WA, Tavarez, UL\u00a0<i>\u0987\u09a4\u09cd\u09af\u09be\u09a6\u09bf<\/i>\u00a0\u09b9\u09be\u099a\u09bf\u09a8\u09b8\u09a8-\u0997\u09bf\u09b2\u09ab\u09cb\u09b0\u09cd\u09a1 \u09aa\u09cd\u09b0\u09cb\u099c\u09c7\u09b0\u09bf\u09af\u09bc\u09be \u09b8\u09bf\u09a8\u09cd\u09a1\u09cd\u09b0\u09cb\u09ae\u09c7\u09b0 \u099c\u09a8\u09cd\u09af \u098f\u0995\u099f\u09bf \u09b2\u0995\u09cd\u09b7\u09cd\u09af\u09af\u09c1\u0995\u09cd\u09a4 \u0985\u09cd\u09af\u09be\u09a8\u09cd\u099f\u09bf\u09b8\u09c7\u09a8\u09cd\u09b8 \u09a5\u09c7\u09b0\u09be\u09aa\u09bf\u0989\u099f\u09bf\u0995 \u09aa\u09a6\u09cd\u09a7\u09a4\u09bf\u0964\u00a0<i>\u09a8\u09cd\u09af\u09be\u099f \u09ae\u09c7\u09a1<\/i>\u00a0(2021)\u0964 https:\/\/doi.org\/10.1038\/s41591-021-01274-0<\/p>\n<p>\u09aa\u09c1\u09a4\u09cd\u09b0\u09b0\u09be\u099c\u09c1, \u098f\u09ae., \u099c\u09cd\u09af\u09be\u0995\u09b8\u09a8, \u098f\u09ae., \u0995\u09cd\u09b2\u09c7\u0987\u09a8, \u098f\u09b8.\u00a0<i>\u0987\u09a4\u09cd\u09af\u09be\u09a6\u09bf<\/i>\u00a0\u09aa\u09a6\u09cd\u09a7\u09a4\u09bf\u0997\u09a4 \u09b8\u09cd\u0995\u09cd\u09b0\u09c0\u09a8\u09bf\u0982 \u09b9\u09be\u099a\u09bf\u09a8\u09b8\u09a8-\u0997\u09bf\u09b2\u09ab\u09cb\u09b0\u09cd\u09a1 \u09aa\u09cd\u09b0\u09cb\u099c\u09c7\u09b0\u09bf\u09af\u09bc\u09be \u09b8\u09bf\u09a8\u09cd\u09a1\u09cd\u09b0\u09cb\u09ae\u09c7\u09b0 \u099c\u09a8\u09cd\u09af \u09a5\u09c7\u09b0\u09be\u09aa\u09bf\u0989\u099f\u09bf\u0995 \u0985\u09cd\u09af\u09be\u09a8\u09cd\u099f\u09bf\u09b8\u09c7\u09a8\u09cd\u09b8 \u0985\u09b2\u09bf\u0997\u09cb\u09a8\u09bf\u0989\u0995\u09cd\u09b2\u09bf\u0993\u099f\u09be\u0987\u09a1 \u09b8\u09a8\u09be\u0995\u09cd\u09a4 \u0995\u09b0\u09c7\u0964\u00a0<i>\u09a8\u09cd\u09af\u09be\u099f \u09ae\u09c7\u09a1<\/i>\u00a0(2021)\u0964 https:\/\/doi.org\/10.1038\/s41591-021-01262-4<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"<p>\u09aa\u09cd\u09b0\u09cb\u099c\u09c7\u09b0\u09bf\u09af\u09bc\u09be \u0997\u09ac\u09c7\u09b7\u09a3\u09be\u09af\u09bc \u0986\u09b0\u098f\u09a8\u098f \u09a5\u09c7\u09b0\u09be\u09aa\u09bf\u0989\u099f\u09bf\u0995\u09b8 \u09ac\u09cd\u09af\u09ac\u09b9\u09be\u09b0\u09c7\u09b0 \u0989\u09aa\u09b0 \u09a6\u09c1\u099f\u09bf \u0985\u09a4\u09cd\u09af\u09a8\u09cd\u09a4 \u0989\u09a4\u09cd\u09a4\u09c7\u099c\u09a8\u09be\u09aa\u09c2\u09b0\u09cd\u09a3 \u09af\u09c1\u0997\u09be\u09a8\u09cd\u09a4\u0995\u09be\u09b0\u09c0 \u0997\u09ac\u09c7\u09b7\u09a3\u09be\u09b0 \u09ab\u09b2\u09be\u09ab\u09b2\u0997\u09c1\u09b2\u09bf \u09ad\u09be\u0997 \u0995\u09b0\u09c7 \u09a8\u09bf\u09a4\u09c7 \u0986\u09ae\u09b0\u09be \u09b0\u09cb\u09ae\u09be\u099e\u09cd\u099a\u09bf\u09a4\u0964 \u0989\u09ad\u09af\u09bc \u0997\u09ac\u09c7\u09b7\u09a3\u09be\u0987 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