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[\/et_pb_text][et_pb_image src=\u201dhttps:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2020\/07\/Registrant-Map-1.jpg\u201d title_text=\u201dRegistrant-Map\u201d align=\u201dcenter\u201d admin_label=\u201dmap\u201d _builder_version=\u201d4.16\u2033 _module_preset=\u201ddefault\u201d custom_margin=\u201d10px||20px||false|false\u201d global_colors_info=\u201d{}\u201d][\/et_pb_image][et_pb_image src=\u201dhttps:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2020\/12\/Complete-Photo.jpg\u201d title_text=\u201dComplete-Photo\u201d align=\u201dcenter\u201d admin_label=\u201dparticipants\u201d _builder_version=\u201d4.16\u2033 _module_preset=\u201d\u09a1\u09bf\u09ab\u09b2\u09cd\u099f\u201d custom_margin=\u201d10px||15px||false|false\u201d global_colors_info=\u201d{}\u201d][\/et_pb_image][et_pb_text admin_label=\u201d\u09ad\u09bf\u09a1\u09bf\u0993 \u0995\u09cd\u09b2\u09bf\u09aa \u099f\u09c7\u0995\u09cd\u09b8\u099f\u201d _builder_version=\u201d4.16\u2033 _module_preset=\u201d\u09a1\u09bf\u09ab\u09b2\u09cd\u099f\u201d global_colors_info=\u201d{}\u201d]<\/p>\n

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[\/et_pb_toggle][et_pb_toggle title=\u201d\u09a1\u09be\u0983 \u09aa\u09bf\u09a8\u09be\u0995 \u09b6\u09be\u09b9 \u098f\u09ac\u0982 \u09a1\u09be\u0983 \u09ab\u09cd\u09b0\u09be\u09a8\u09cd\u09b8\u09c7\u09b8\u09cd\u0995\u09cb \u09ae\u09c1\u09b8\u09c1\u09ae\u09c7\u09b8\u09bf\u09b0 \u09aa\u09cd\u09b0\u09a4\u09bf: \u09aa\u09cd\u09b0\u09b6\u09cd\u09a8: RVB \u09a5\u09c7\u0995\u09c7: \u09ae\u09cd\u09af\u09be\u0997\u09a8\u09c7\u09b8\u09bf\u09af\u09bc\u09be\u09ae\/\u0995\u09cd\u09af\u09be\u09b2\u09b8\u09bf\u09af\u09bc\u09be\u09ae \u0997\u09cd\u09b0\u09b9\u09a3 \u0995\u09bf HGPS \u0986\u0995\u09cd\u09b0\u09be\u09a8\u09cd\u09a4 \u09b6\u09bf\u09b6\u09c1\u09a6\u09c7\u09b0 \u0995\u09cd\u09af\u09be\u09b2\u09b8\u09bf\u09ab\u09bf\u0995\u09c7\u09b6\u09a8\u09c7\u09b0 \u09ae\u09be\u09a4\u09cd\u09b0\u09be \u09a8\u09bf\u09b0\u09cd\u09a7\u09be\u09b0\u09a3 \u0995\u09b0\u09a4\u09c7 \u09aa\u09be\u09b0\u09c7?\u201d open_toggle_background_color=\u201d#f7f7f7\u2033 closed_toggle_text_color=\u201d#ffffff\u201d closed_toggle_background_color=\u201d#00b2e2\u2033 icon_color=\u201d#ffc15e\u201d open_icon_color=\u201d#ffc15e\u201d admin_label=\u201d\u09b6\u09be\u09b9 \u098f\u09ac\u0982 \u09ae\u09c1\u09b8\u09c1\u09ae\u09c7\u09b8\u09bf\u09b0 \u09aa\u09cd\u09b0\u09b6\u09cd\u09a8\u09cb\u09a4\u09cd\u09a4\u09b0\u201d _builder_version=\u201d4.16\u2033 _module_preset=\u201ddefault\u201d title_text_color=\u201d#00b2e2\u2033 title_font=\u201d||||||\u201d \u09ac\u09cd\u09af\u09be\u0995\u0997\u09cd\u09b0\u09be\u0989\u09a8\u09cd\u09a1_\u09b0\u0999=\u201d#ffffff\u201d \u0995\u09be\u09b8\u09cd\u099f\u09ae_\u09ae\u09be\u09b0\u09cd\u099c\u09bf\u09a8=\u201d||25px\u201d \u0995\u09be\u09b8\u09cd\u099f\u09ae_\u09aa\u09cd\u09af\u09be\u09a1\u09bf\u0982=\u201d|50px||50px||\u09b8\u09a4\u09cd\u09af\u201d \u09ac\u09b0\u09cd\u09a1\u09be\u09b0_\u0989\u0987\u09a5_\u09b8\u09ac=\u201d0px\u201d \u0997\u09cd\u09b2\u09cb\u09ac\u09be\u09b2_\u09b0\u0999_\u09a4\u09a5\u09cd\u09af=\u201d{}\u201d]<\/p>\n

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 <\/p>\n

 <\/p>\n

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\"\"\u0989\u09a4\u09cd\u09a4\u09b0\u0983 <\/strong>\u09b2\u09cd\u09af\u09be\u09ae\u09bf\u09a8 A\/C \u09a8\u09be\u09b2 (\u09b2\u09ae\u09a8\u09be<\/em>-\/-<\/sup>) \u09ae\u09be\u0989\u09b8 \u09ae\u09a1\u09c7\u09b2 \u0995\u09be\u09b0\u09cd\u09a1\u09bf\u09af\u09bc\u09be\u0995 \u09ab\u09be\u0982\u09b6\u09a8 \u09b9\u09be\u09b0\u09be\u09a8\u09cb\u09b0 \u09b8\u09be\u09a5\u09c7 DCM \u09ac\u09bf\u0995\u09be\u09b6 \u0995\u09b0\u09c7\u0964 \u0985\u09a7\u09bf\u0995\u09a8\u09cd\u09a4\u09c1, \u098f\u0987 \u0987\u0981\u09a6\u09c1\u09b0\u0997\u09c1\u09b2\u09bf \u0995\u09be\u09b0\u09cd\u09a1\u09bf\u09af\u09bc\u09be\u0995 \u09b8\u099e\u09cd\u099a\u09be\u09b2\u09a8 \u098f\u09ac\u0982 \u09ac\u09cd\u09af\u09be\u09aa\u0995 \u0995\u09be\u09b0\u09cd\u09a1\u09bf\u09af\u09bc\u09be\u0995 \u09ab\u09be\u0987\u09ac\u09cd\u09b0\u09cb\u09b8\u09bf\u09b8 \u098f\u09ac\u0982 5-8 \u09b8\u09aa\u09cd\u09a4\u09be\u09b9 \u09ac\u09af\u09bc\u09b8\u09c7 \u0985\u0995\u09be\u09b2 \u09ae\u09c3\u09a4\u09cd\u09af\u09c1 \u09aa\u09cd\u09b0\u09a6\u09b0\u09cd\u09b6\u09a8 \u0995\u09b0\u09c7 (\u0985\u0997\u09be\u09b8\u09cd\u099f \u098f\u099f \u0986\u09b2\u0964, 2018; \u09ab\u09cd\u09b0\u0995 \u098f\u099f \u0986\u09b2\u0964, 2012; \u09b8\u09c1\u09b2\u09bf\u09ad\u09be\u09a8, 1999)\u0964 \u09af\u09be\u0987\u09b9\u09cb\u0995, \u09b6\u09c1\u09a7\u09c1\u09ae\u09be\u09a4\u09cd\u09b0 Lamin A (Fong et al., 2006) \u09ac\u09be lamin C (Coffinier et al., 2010) \u09a8\u09c7\u0987 \u098f\u09ae\u09a8 \u09ae\u09be\u0989\u09b8 \u09ae\u09a1\u09c7\u09b2\u0997\u09c1\u09b2\u09bf \u0995\u09be\u09b0\u09cd\u09a1\u09bf\u09af\u09bc\u09be\u0995 \u09a4\u09cd\u09b0\u09c1\u099f\u09bf\u0997\u09c1\u09b2\u09bf \u09a6\u09c7\u0996\u09be\u09af\u09bc \u09a8\u09be \u098f\u09ac\u0982 \u098f\u0995\u099f\u09bf \u09b8\u09cd\u09ac\u09be\u09ad\u09be\u09ac\u09bf\u0995 \u099c\u09c0\u09ac\u09a8\u0995\u09be\u09b2 \u09a5\u09be\u0995\u09c7\u0964<\/p>\n

\u09a4\u09a5\u09cd\u09af\u09b8\u09c2\u09a4\u09cd\u09b0:
<\/strong>Auguste, G., Gurha, P., Lombardi, R., Coarfa, C., Willerson, JT, & Marian, AJ (2018)\u0964 \u09b9\u09be\u09b0\u09cd\u099f\u09c7 \u09b8\u0995\u09cd\u09b0\u09bf\u09af\u09bc FOXO \u099f\u09cd\u09b0\u09be\u09a8\u09cd\u09b8\u0995\u09cd\u09b0\u09bf\u09aa\u09b6\u09a8 \u09ab\u09cd\u09af\u09be\u0995\u09cd\u099f\u09b0\u0997\u09c1\u09b2\u09bf\u09b0 \u09a6\u09ae\u09a8 \u09b2\u09cd\u09af\u09be\u09ae\u09bf\u09a8\u09cb\u09aa\u09cd\u09af\u09be\u09a5\u09bf\u09b0 \u09ae\u09be\u0989\u09b8 \u09ae\u09a1\u09c7\u09b2\u09c7 \u09ac\u09c7\u0981\u099a\u09c7 \u09a5\u09be\u0995\u09be\u0995\u09c7 \u09a6\u09c0\u09b0\u09cd\u0998\u09be\u09af\u09bc\u09bf\u09a4 \u0995\u09b0\u09c7<\/em>. https:\/\/doi.org\/10.1161\/CIRCRESAHA.117.312052<\/a><\/p>\n

\u0995\u09ab\u09bf\u09a8\u09bf\u09af\u09bc\u09be\u09b0, \u09b8\u09bf., \u099c\u0982, \u098f\u0987\u099a\u099c\u09c7, \u09b2\u09bf, \u099c\u09c7\u09a1., \u09a8\u09cb\u09ac\u09c1\u09ae\u09cb\u09b0\u09bf, \u09b8\u09bf., \u0987\u0989\u09a8, \u0987\u0989\u099c\u09c7, \u09ab\u09be\u09b0\u09cd\u09ac\u09be\u09b0, \u0987\u098f, \u09a1\u09c7\u09ad\u09bf\u09b8, \u09ac\u09bf\u098f\u09b8, \u0993\u09af\u09bc\u09c7\u0987\u09a8\u09b8\u09cd\u099f\u09c7\u0987\u09a8, \u098f\u09ae\u098f\u09ae, \u0987\u09af\u09bc\u09be\u0982, \u098f\u09b8\u098f\u0987\u099a, \u09b2\u09cd\u09af\u09be\u09ae\u09be\u09b0\u09a1\u09bf\u0982, \u099c\u09c7., \u09ab\u09be\u09b0\u09be\u09b9\u09be\u09a8\u09bf, \u099c\u09c7\u098f\u09a8, \u09ac\u09c7\u09a8\u09cd\u099f\u09cb\u09b2\u09bf\u09b2\u09be, LA, Fong, LG, & Young, SG (2010)\u0964 \u09b2\u09cd\u09af\u09be\u09ae\u09bf\u09a8 A-\u098f\u09b0 \u09aa\u09cd\u09b0\u09a4\u09cd\u09af\u0995\u09cd\u09b7 \u09b8\u0982\u09b6\u09cd\u09b2\u09c7\u09b7\u09a3, \u09aa\u09cd\u09b0\u09bf\u09b2\u09be\u09ae\u09bf\u09a8 \u098f\u0995\u099f\u09bf \u09aa\u09cd\u09b0\u0995\u09cd\u09b0\u09bf\u09af\u09bc\u09be\u0995\u09b0\u09a3\u0995\u09c7 \u09ac\u09be\u0987\u09aa\u09be\u09b8 \u0995\u09b0\u09c7, \u09ab\u09be\u0987\u09ac\u09cd\u09b0\u09cb\u09ac\u09cd\u09b2\u09be\u09b8\u09cd\u099f\u09c7 \u09ae\u09bf\u09b6\u09c7\u09aa\u09c7\u09a8 \u09a8\u09bf\u0989\u0995\u09cd\u09b2\u09bf\u09af\u09bc\u09be\u09b8 \u09b8\u09c3\u09b7\u09cd\u099f\u09bf \u0995\u09b0\u09c7 \u0995\u09bf\u09a8\u09cd\u09a4\u09c1 \u0987\u0981\u09a6\u09c1\u09b0\u09c7\u09b0 \u09ae\u09a7\u09cd\u09af\u09c7 \u09b8\u09a8\u09be\u0995\u09cd\u09a4\u09af\u09cb\u0997\u09cd\u09af \u09aa\u09cd\u09af\u09be\u09a5\u09b2\u099c\u09bf \u09a8\u09c7\u0987\u0964 \u099c\u09c8\u09ac\u09bf\u0995 \u09b0\u09b8\u09be\u09af\u09bc\u09a8 \u099c\u09be\u09b0\u09cd\u09a8\u09be\u09b2<\/em>, 285<\/em>(27), 20818\u201320826\u0964 https:\/\/doi.org\/10.1074\/jbc.M110.128835<\/a><\/p>\n

Fong, LG, Bergo, MO, Young, SG, Fong, LG, Ng, JK, Lammerding, J., Vickers, TA, Meta, M., Cot\u00e9, N., Gavino, B., Qiao, X., Chang , SY, Young, SR, Yang, SH, Stewart, CL, Lee, RT, Bennett, CF, Bergo, MO, & Young, \u098f\u09b8\u099c\u09bf (2006)\u0964 \u09aa\u09cd\u09b0\u09bf\u09b2\u09be\u09ae\u09bf\u09a8 \u098f \u098f\u09ac\u0982 \u09b2\u09cd\u09af\u09be\u09ae\u09bf\u09a8 \u098f \u09aa\u09be\u09b0\u09ae\u09be\u09a3\u09ac\u09bf\u0995 \u09b2\u09cd\u09af\u09be\u09ae\u09bf\u09a8\u09be\u09a4\u09c7 \u09b8\u09b0\u09ac\u09b0\u09be\u09b9\u09af\u09cb\u0997\u09cd\u09af \u09ac\u09b2\u09c7 \u09ae\u09a8\u09c7 \u09b9\u09af\u09bc\u0964 \u0995\u09cd\u09b2\u09bf\u09a8\u09bf\u0995\u09cd\u09af\u09be\u09b2 \u0987\u09a8\u09ad\u09c7\u09b8\u09cd\u099f\u09bf\u0997\u09c7\u09b6\u09a8 \u099c\u09be\u09b0\u09cd\u09a8\u09be\u09b2<\/em>, 116<\/em>(\u09e9), \u09ed\u09ea\u09e9\u2013\u09ed\u09eb\u09e8\u0964 https:\/\/doi.org\/10.1172\/JCI27125.with<\/a><\/p>\n

Frock, RL, Chen, SC, Da, D., Frett, E., Lau, C., Brown, C., Pak, DN, Wang, Y., Muchir, A., Worman, HJ, Santana, LF, Ladiges, WC, Rabinovitch, PS, & Kennedy, BK (2012)\u0964 \u09b2\u09be\u09ae\u09bf\u09a8 A-\u098f\u09b0 \u0995\u09be\u09b0\u09cd\u09a1\u09bf\u0993\u09ae\u09be\u09af\u09bc\u09cb\u09b8\u09be\u0987\u099f-\u09a8\u09bf\u09b0\u09cd\u09a6\u09bf\u09b7\u09cd\u099f \u09aa\u09cd\u09b0\u0995\u09be\u09b6 Lmna-\/- \u0987\u0981\u09a6\u09c1\u09b0\u09c7\u09b0 \u0995\u09be\u09b0\u09cd\u09a1\u09bf\u09af\u09bc\u09be\u0995 \u09ab\u09be\u0982\u09b6\u09a8 \u0989\u09a8\u09cd\u09a8\u09a4 \u0995\u09b0\u09c7\u0964 \u09aa\u09cd\u09b2\u09be\u09b8 \u0993\u09af\u09bc\u09be\u09a8<\/em>, 7<\/em>(8), 1-9\u0964 https:\/\/doi.org\/10.1371\/journal.pone.0042918<\/a><\/p>\n

\u09b8\u09c1\u09b2\u09bf\u09ad\u09be\u09a8, \u099f\u09bf. (1999)\u0964 \u098f-\u099f\u09be\u0987\u09aa \u09b2\u09cd\u09af\u09be\u09ae\u09bf\u09a8 \u098f\u0995\u09cd\u09b8\u09aa\u09cd\u09b0\u09c7\u09b6\u09a8\u09c7\u09b0 \u0995\u09cd\u09b7\u09a4\u09bf \u09aa\u09be\u09b0\u09ae\u09be\u09a3\u09ac\u09bf\u0995 \u0996\u09be\u09ae\u09c7\u09b0 \u0985\u0996\u09a3\u09cd\u09a1\u09a4\u09be\u0995\u09c7 \u0986\u09aa\u09b8 \u0995\u09b0\u09c7 \u09af\u09be \u09aa\u09c7\u09b6\u09c0\u09ac\u09b9\u09c1\u09b2 \u09a1\u09bf\u09b8\u09cd\u099f\u09cd\u09b0\u09cb\u09ab\u09bf\u09b0 \u09a6\u09bf\u0995\u09c7 \u09aa\u09b0\u09bf\u099a\u09be\u09b2\u09bf\u09a4 \u0995\u09b0\u09c7\u0964 \u09a6\u09cd\u09af \u099c\u09be\u09b0\u09cd\u09a8\u09be\u09b2 \u0985\u09ab \u09b8\u09c7\u09b2 \u09ac\u09be\u09af\u09bc\u09cb\u09b2\u099c\u09bf<\/em>, 147<\/em>(5), 913-920\u0964 https:\/\/doi.org\/10.1083\/jcb.147.5.913<\/a><\/p>\n

[\/et_pb_toggle][et_pb_toggle title=\u201d \u09a1\u0983 \u099c\u09bf\u0993\u09ad\u09be\u09a8\u09cd\u09a8\u09be \u09b2\u09be\u099f\u09be\u09a8\u099c\u09bf\u09b0 \u09aa\u09cd\u09b0\u09a4\u09bf: \u09a1\u0983 \u09b2\u09be\u099f\u09be\u09a8\u099c\u09bf\u09b0 \u099c\u09a8\u09cd\u09af \u09e8\u099f\u09bf \u09aa\u09cd\u09b0\u09b6\u09cd\u09a8\u09cb\u09a4\u09cd\u09a4\u09b0 \u09a8\u09c0\u099a\u09c7 \u09a4\u09be\u09b2\u09bf\u0995\u09be\u09ad\u09c1\u0995\u09cd\u09a4\u0964\u201d open_toggle_background_color=\u201d#f7f7f7\u2033 closed_toggle_text_color=\u201d#ffffff\u201d closed_toggle_background_color=\u201d#00b2e2\u2033 icon_color=\u201d#ffc15e\u201d open_icon_color=\u201d#ffc15e\u201d admin_label=\u201d\u09b2\u099f\u09be\u09a8\u099c\u09bf\u09b0 \u09aa\u09cd\u09b0\u09b6\u09cd\u09a8\u09cb\u09a4\u09cd\u09a4\u09b0 \u09e8\u2033 _builder_version=\u201d4.16\u2033 _module_preset=\u201ddefault\u201d title_text_color=\u201d#00b2e2\u2033 title_font=\u201d||||||\u201d \u09ac\u09cd\u09af\u09be\u0995\u0997\u09cd\u09b0\u09be\u0989\u09a8\u09cd\u09a1_\u09b0\u0999=\u201d#ffffff\u201d \u0995\u09be\u09b8\u09cd\u099f\u09ae_\u09ae\u09be\u09b0\u09cd\u099c\u09bf\u09a8=\u201d||25px\u201d \u0995\u09be\u09b8\u09cd\u099f\u09ae_\u09aa\u09cd\u09af\u09be\u09a1\u09bf\u0982=\u201d|50px||50px||\u09b8\u09a4\u09cd\u09af\u201d \u09ac\u09b0\u09cd\u09a1\u09be\u09b0_\u0989\u0987\u09a5_\u09b8\u09ac=\u201d0px\u201d \u0997\u09cd\u09b2\u09cb\u09ac\u09be\u09b2_\u09b0\u0999_\u09a4\u09a5\u09cd\u09af=\u201d{}\u201d]<\/p>\n

\"\"\u09aa\u09cd\u09b0\u09b6\u09cd\u09a8\u0983<\/span> <\/strong>\u099f\u09ae \u09ae\u09bf\u09b8\u09cd\u099f\u09c7\u09b2\u09bf \u09a5\u09c7\u0995\u09c7: \u09aa\u09cd\u09b0\u09be\u09a3\u09c0\u09a6\u09c7\u09b0 \u09ae\u09a7\u09cd\u09af\u09c7 \u09b2\u09cb\u09a8\u09be\u09ab\u09be\u09b0\u09a8\u09bf\u09ac + \u099f\u09cb\u099c\u09bf\u09b2\u09bf\u099c\u09c1\u09ae\u09be\u09ac \u099a\u09bf\u0995\u09bf\u09a4\u09cd\u09b8\u09be \u0995\u09a4\u0995\u09cd\u09b7\u09a3 \u099b\u09bf\u09b2?
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\u09aa\u09cd\u09b0\u09b6\u09cd\u09a8\u0983 <\/strong><\/span>Sgonzalo \u09a5\u09c7\u0995\u09c7: \u09b8\u09c1\u09a8\u09cd\u09a6\u09b0 \u0997\u09b2\u09cd\u09aa \u099c\u09bf\u0993\u09ad\u09be\u09a8\u09be \u098f\u09ac\u0982 \u09b8\u09cd\u09af\u09be\u09ae\u09bf!!! \u0986\u09aa\u09a8\u09bf \u0995\u09bf tocilizumab \u099a\u09bf\u0995\u09bf\u09ce\u09b8\u09be\u09b0 \u0995\u09cb\u09a8 \u09aa\u09be\u09b0\u09cd\u09b6\u09cd\u09ac\u09aa\u09cd\u09b0\u09a4\u09bf\u0995\u09cd\u09b0\u09bf\u09af\u09bc\u09be \u09a6\u09c7\u0996\u09c7\u099b\u09c7\u09a8? \u09ac\u09be \u0995\u09cb\u09a8 \u09ab\u09c7\u09a8\u09cb\u099f\u09be\u0987\u09aa \u09af\u09be \u09aa\u09cd\u09b0\u09cb\u099c\u09c7\u09b0\u09bf\u09af\u09bc\u09be \u0987\u0981\u09a6\u09c1\u09b0\u09c7 \u0989\u09a8\u09cd\u09a8\u09a4 \u09b9\u09af\u09bc\u09a8\u09bf? \u09a1\u09be\u0983 \u099c\u09bf\u0993\u09ad\u09be\u09a8\u09be \u09b2\u09cd\u09af\u09be\u099f\u09be\u09a8\u099c\u09bf\u09b0 \u0995\u09be\u099b\u09c7: \u09aa\u09cd\u09b0\u09b6\u09cd\u09a8: \u099f\u09ae \u09ae\u09bf\u09b8\u09cd\u099f\u09c7\u09b2\u09bf \u09a5\u09c7\u0995\u09c7: \u09aa\u09cd\u09b0\u09be\u09a3\u09c0\u09a6\u09c7\u09b0 \u09b2\u09cb\u09a8\u09be\u09ab\u09be\u09b0\u09a8\u09bf\u09ac + \u099f\u09cb\u099c\u09bf\u09b2\u09bf\u099c\u09c1\u09ae\u09be\u09ac \u0995\u09a4\u09a6\u09bf\u09a8 \u09a7\u09b0\u09c7 \u099a\u09bf\u0995\u09bf\u09a4\u09cd\u09b8\u09be \u0995\u09b0\u09be \u09b9\u09af\u09bc\u09c7\u099b\u09bf\u09b2?
\u0989\u09a4\u09cd\u09a4\u09b0\u0983 <\/strong><\/span>\u09a7\u09a8\u09cd\u09af\u09ac\u09be\u09a6 \u09b8\u09c1\u099c\u09be\u09a8\u09be\u0964 \u09a8\u09be, \u0986\u09ae\u09b0\u09be tocilizumab \u098f\u09b0 \u0995\u09cb\u09a8\u09cb \u09aa\u09be\u09b0\u09cd\u09b6\u09cd\u09ac\u09aa\u09cd\u09b0\u09a4\u09bf\u0995\u09cd\u09b0\u09bf\u09af\u09bc\u09be \u09a6\u09c7\u0996\u09bf\u09a8\u09bf\u0964 \u09aa\u09b0\u09c0\u0995\u09cd\u09b7\u09bf\u09a4 \u09ab\u09c7\u09a8\u09cb\u099f\u09be\u0987\u09aa\u0997\u09c1\u09b2\u09bf\u09b0 \u09ae\u09a7\u09cd\u09af\u09c7 (\u0995\u09be\u0987\u09ab\u09cb\u09b8\u09bf\u09b8, \u0985\u09cd\u09af\u09be\u09a1\u09bf\u09aa\u09cb\u099c \u099f\u09bf\u09b8\u09cd\u09af\u09c1 \u09a1\u09bf\u09b8\u09cd\u099f\u09cd\u09b0\u09cb\u09ab\u09bf, \u099a\u09c1\u09b2 \u098f\u09ac\u0982 \u09a4\u09cd\u09ac\u0995\u09c7\u09b0 \u09a4\u09cd\u09b0\u09c1\u099f\u09bf, \u09b2\u09cb\u0995\u09cb\u09ae\u09cb\u099f\u09b0 \u0995\u09be\u09b0\u09cd\u09af\u0995\u09b2\u09be\u09aa, \u09ae\u09b9\u09be\u09a7\u09ae\u09a8\u09c0\u09b0 \u0995\u09cd\u09b7\u09a4 \u098f\u09ac\u0982 \u09ae\u09be\u09af\u09bc\u09cb\u0995\u09be\u09b0\u09cd\u09a1\u09bf\u09af\u09bc\u09be\u09ae \u09b9\u09be\u0987\u09aa\u09be\u09b0\u09a5\u09cd\u09b0\u09ab\u09bf) \u09ac\u09bf\u09b2\u09ae\u09cd\u09ac\u09bf\u09a4\/\u0989\u09a8\u09cd\u09a8\u09a4 \u099b\u09bf\u09b2\u0964<\/p>\n

\u09ae\u09a8\u09cd\u09a4\u09ac\u09cd\u09af: <\/strong><\/span>MARIE GERHARD-HERMAN \u09a5\u09c7\u0995\u09c7: \u098f\u099b\u09be\u09a1\u09bc\u09be\u0993 \u09ae\u09be\u09b0\u09cd\u0995\u09bf\u09a8 \u09af\u09c1\u0995\u09cd\u09a4\u09b0\u09be\u09b7\u09cd\u099f\u09cd\u09b0\u09c7 \u09b0\u09bf\u0989\u09ae\u09be\u099f\u09cb\u09b2\u099c\u09bf\u09b8\u09cd\u099f \u09b0\u09cb\u0997 \u098f\u09ac\u0982 \u09ad\u09be\u09b8\u09cd\u0995\u09c1\u09b2\u09be\u0987\u099f\u09bf\u09b8\u09c7\u09b0 \u099c\u09a8\u09cd\u09af \u09ac\u09cd\u09af\u09ac\u09b9\u09c3\u09a4 \u09b9\u09af\u09bc
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\"\"\"\" <\/strong><\/p>\n

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\"\"<\/p>\n

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HGPS \u0995\u09cb\u09b7\u0964<\/p>\n

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[\/et_pb_toggle][et_pb_toggle title=\u201d\u09a1\u0983 \u09ae\u09be\u09b0\u09cd\u099f\u09bf\u09a8 \u09ac\u09be\u09b0\u09cd\u0997\u09cb\u09b0 \u09aa\u09cd\u09b0\u09a4\u09bf: \u09aa\u09cd\u09b0\u09b6\u09cd\u09a8: \u09ae\u09be\u09b0\u09bf\u0993 \u09a1\u09bf. \u0995\u09b0\u09cd\u09a1\u09c7\u09b0\u09cb\u09b0 \u0995\u09be\u099b \u09a5\u09c7\u0995\u09c7: \u0986\u09aa\u09a8\u09bf \u0995\u09bf \u09aa\u09cd\u09b0\u09a6\u09be\u09b9\u09c7\u09b0 \u09aa\u09cd\u09b0\u09ad\u09be\u09ac \u09b8\u09ae\u09cd\u09aa\u09b0\u09cd\u0995\u09c7 \u0985\u09a7\u09cd\u09af\u09af\u09bc\u09a8 \u0995\u09b0\u09c7\u099b\u09c7\u09a8?\u201d open_toggle_background_color=\u201d#f7f7f7\u2033 closed_toggle_text_color=\u201d#ffffff\u201d closed_toggle_background_color=\u201d#00b2e2\u2033 icon_color=\u201d#ffc15e\u201d open_icon_color=\u201d#ffc15e\u201d admin_label=\u201d\u09a1\u0983 \u09ae\u09be\u09b0\u09cd\u099f\u09bf\u09a8 \u09ac\u09be\u09b0\u09cd\u0997\u09cb\u09b0\u201d _builder_version=\u201d4.16\u2033 _module_preset=\u201ddefault\u201d title_text_color=\u201d#00b2e2\u2033 title_font=\u201d||||||\u201d \u09ac\u09cd\u09af\u09be\u0995\u0997\u09cd\u09b0\u09be\u0989\u09a8\u09cd\u09a1_\u09b0\u0999=\u201d#ffffff\u201d \u0995\u09be\u09b8\u09cd\u099f\u09ae_\u09ae\u09be\u09b0\u09cd\u099c\u09bf\u09a8=\u201d||25px\u201d \u0995\u09be\u09b8\u09cd\u099f\u09ae_\u09aa\u09cd\u09af\u09be\u09a1\u09bf\u0982=\u201d|50px||50px||\u09b8\u09a4\u09cd\u09af\u201d \u09ac\u09b0\u09cd\u09a1\u09be\u09b0_\u0989\u0987\u09a5_\u09b8\u09ac=\u201d0px\u201d \u0997\u09cd\u09b2\u09cb\u09ac\u09be\u09b2_\u09b0\u0999_\u09a4\u09a5\u09cd\u09af=\u201d{}\u201d]<\/p>\n

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[\/et_pb_toggle][et_pb_toggle title=\u201d\u09a1\u0983 \u09a1\u09c7\u09ad\u09bf\u09a1 \u09b2\u09bf\u0989-\u098f\u09b0 \u09aa\u09cd\u09b0\u09a4\u09bf: \u09aa\u09cd\u09b0\u09b6\u09cd\u09a8: \u09a1\u0983 \u09b2\u09c1\u0987-\u098f\u09b0 \u099c\u09a8\u09cd\u09af \u09e9\u099f\u09bf \u09aa\u09cd\u09b0\u09b6\u09cd\u09a8\u09cb\u09a4\u09cd\u09a4\u09b0 \u09a8\u09c0\u099a\u09c7 \u09a4\u09be\u09b2\u09bf\u0995\u09be\u09ad\u09c1\u0995\u09cd\u09a4\u0964\u201d open_toggle_background_color=\u201d#f7f7f7\u2033 closed_toggle_text_color=\u201d#ffffff\u201d closed_toggle_background_color=\u201d#00b2e2\u2033 icon_color=\u201d#ffc15e\u201d open_icon_color=\u201d#ffc15e\u201d admin_label=\u201d\u09a1\u0983 \u09a1\u09c7\u09ad\u09bf\u09a1 \u09b2\u09bf\u0989-\u098f\u09b0 \u09aa\u09cd\u09b0\u09b6\u09cd\u09a8\u09cb\u09a4\u09cd\u09a4\u09b0 \u09e9\u2033 _builder_version=\u201d4.16\u2033 _module_preset=\u201ddefault\u201d title_text_color=\u201d#00b2e2\u2033 title_font=\u201d||||||\u201d \u09ac\u09cd\u09af\u09be\u0995\u0997\u09cd\u09b0\u09be\u0989\u09a8\u09cd\u09a1_\u09b0\u0999=\u201d#ffffff\u201d \u0995\u09be\u09b8\u09cd\u099f\u09ae_\u09ae\u09be\u09b0\u09cd\u099c\u09bf\u09a8=\u201d||25px\u201d \u0995\u09be\u09b8\u09cd\u099f\u09ae_\u09aa\u09cd\u09af\u09be\u09a1\u09bf\u0982=\u201d|50px||50px||\u09b8\u09a4\u09cd\u09af\u201d \u09ac\u09b0\u09cd\u09a1\u09be\u09b0_\u0989\u0987\u09a5_\u09b8\u09ac=\u201d0px\u201d \u0997\u09cd\u09b2\u09cb\u09ac\u09be\u09b2_\u09b0\u0999_\u09a4\u09a5\u09cd\u09af=\u201d{}\u201d]<\/p>\n

\"\"<\/p>\n

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[\/et_pb_toggle][et_pb_toggle title=\u201d\u09a1\u0983 \u0995\u09b2\u09bf\u09a8 \u09b8\u09cd\u099f\u09c1\u09af\u09bc\u09be\u09b0\u09cd\u099f\u09c7\u09b0 \u09aa\u09cd\u09b0\u09a4\u09bf: \u09a1\u0983 \u09b8\u09cd\u099f\u09c1\u09af\u09bc\u09be\u09b0\u09cd\u099f\u09c7\u09b0 \u099c\u09a8\u09cd\u09af \u09ee\u099f\u09bf \u09aa\u09cd\u09b0\u09b6\u09cd\u09a8\u09cb\u09a4\u09cd\u09a4\u09b0 \u09a8\u09c0\u099a\u09c7 \u09a4\u09be\u09b2\u09bf\u0995\u09be\u09ad\u09c1\u0995\u09cd\u09a4 \u0995\u09b0\u09be \u09b9\u09af\u09bc\u09c7\u099b\u09c7\u0964\u201d open_toggle_background_color=\u201d#f7f7f7\u2033 closed_toggle_text_color=\u201d#ffffff\u201d closed_toggle_background_color=\u201d#00b2e2\u2033 icon_color=\u201d#ffc15e\u201d open_icon_color=\u201d#ffc15e\u201d admin_label=\u201d\u09a1\u0983 \u0995\u09b2\u09bf\u09a8 \u09b8\u09cd\u099f\u09c1\u09af\u09bc\u09be\u09b0\u09cd\u099f\u201d _builder_version=\u201d4.16\u2033 _module_preset=\u201ddefault\u201d title_text_color=\u201d#00b2e2\u2033 title_font=\u201d||||||\u201d \u09ac\u09cd\u09af\u09be\u0995\u0997\u09cd\u09b0\u09be\u0989\u09a8\u09cd\u09a1_\u09b0\u0999=\u201d#ffffff\u201d \u0995\u09be\u09b8\u09cd\u099f\u09ae_\u09ae\u09be\u09b0\u09cd\u099c\u09bf\u09a8=\u201d||25px\u201d \u0995\u09be\u09b8\u09cd\u099f\u09ae_\u09aa\u09cd\u09af\u09be\u09a1\u09bf\u0982=\u201d|50px||50px||\u09b8\u09a4\u09cd\u09af\u201d \u09ac\u09b0\u09cd\u09a1\u09be\u09b0_\u0989\u0987\u09a5_\u09b8\u09ac=\u201d0px\u201d \u0997\u09cd\u09b2\u09cb\u09ac\u09be\u09b2_\u09b0\u0999_\u09a4\u09a5\u09cd\u09af=\u201d{}\u201d]<\/p>\n

\"\"\u09aa\u09cd\u09b0\u09b6\u09cd\u09a8\u0983<\/strong><\/span> \u09ae\u09c7\u0987 \u09a5\u09c7\u0995\u09c7: \u0995\u09be\u09b0\u09cd\u09a1\u09bf\u0993\u09ae\u09be\u09af\u09bc\u09cb\u09b8\u09be\u0987\u099f\u09c7\u09b0 \u09ae\u09a4\u09cb \u09a6\u09c7\u0996\u09be\u099a\u09cd\u099b\u09c7, \u09b8\u09c1\u09a8\u09cd\u09a6\u09b0 \u09a6\u09be\u0997!
Abby Buchwalter \u09a5\u09c7\u0995\u09c7: \u09aa\u09cd\u09b0\u09ad\u09be\u09ac\u09b6\u09be\u09b2\u09c0 \u09a8\u09c7\u09a4\u09bf\u09ac\u09be\u099a\u0995 Sun1 \u0985\u09ad\u09bf\u09ac\u09cd\u09af\u0995\u09cd\u09a4\u09bf \u0995\u09bf Sun2 \u09a6\u09cd\u09ac\u09be\u09b0\u09be \u09ae\u09a7\u09cd\u09af\u09b8\u09cd\u09a5\u09a4\u09be \u09b8\u09b9 \u09b8\u09ae\u09b8\u09cd\u09a4 LINC \u0995\u09ae\u09aa\u09cd\u09b2\u09c7\u0995\u09cd\u09b8\u0995\u09c7 \u09ac\u09cd\u09af\u09be\u09b9\u09a4 \u0995\u09b0\u09c7?
\u0989\u09a4\u09cd\u09a4\u09b0\u0983<\/span> <\/strong>\u09b9\u09cd\u09af\u09be\u0981 \u09ad\u09bf\u099f\u09cd\u09b0\u09cb\u09a4\u09c7 \u098f\u09b0 \u099c\u09a8\u09cd\u09af \u09aa\u09cd\u09b0\u09ae\u09be\u09a3 \u09b0\u09af\u09bc\u09c7\u099b\u09c7 \u09af\u09c7 NE \u098f\u09b0 \u09b8\u09ae\u09b8\u09cd\u09a4 \u09a8\u09c7\u09b8\u09aa\u09cd\u09b0\u09bf\u09a8 DNSUN1 \u09a6\u09cd\u09ac\u09be\u09b0\u09be \u09b8\u09cd\u09a5\u09be\u09a8\u099a\u09cd\u09af\u09c1\u09a4 \u09b9\u09a4\u09c7 \u09aa\u09be\u09b0\u09c7<\/p>\n

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\u0989\u09a4\u09cd\u09a4\u09b0\u0983<\/span> <\/strong>\u0986\u09ae\u09b0\u09be LaminA \u09ae\u09c1\u099b\u09c7 \u09ab\u09c7\u09b2\u09be\u09b0 \u099c\u09a8\u09cd\u09af Cre recombinase \u09aa\u09cd\u09b0\u09b0\u09cb\u099a\u09bf\u09a4 \u0995\u09b0\u09be\u09b0 \u098f\u0995\u09a6\u09bf\u09a8 \u09aa\u09b0\u09c7 DNSUN1 AAV \u0987\u09a8\u099c\u09c7\u0995\u09b6\u09a8 \u09a6\u09bf\u09af\u09bc\u09c7\u099b\u09bf\u09b2\u09be\u09ae\u0964 \u0986\u09ae\u09be\u09a6\u09c7\u09b0 \u0995\u09be\u099b\u09c7 \u09a1\u09c7\u099f\u09be \u09b0\u09af\u09bc\u09c7\u099b\u09c7 \u09af\u09c7 AAV \u09a6\u09cd\u09ac\u09be\u09b0\u09be \u09ac\u09bf\u09a4\u09b0\u09a3 \u0995\u09b0\u09be DNSUN1 \u0987\u09a8\u099c\u09c7\u0995\u09b6\u09a8\u09c7\u09b0 \u098f\u0995 \u09ac\u099b\u09b0 \u09aa\u09b0\u09c7 \u0995\u09be\u09b0\u09cd\u09a1\u09bf\u0993\u09ae\u09be\u09af\u09bc\u09cb\u09b8\u09be\u0987\u099f\u0997\u09c1\u09b2\u09bf\u09a4\u09c7 \u09aa\u09cd\u09b0\u0995\u09be\u09b6 \u0995\u09b0\u09be \u0985\u09ac\u09cd\u09af\u09be\u09b9\u09a4 \u09a5\u09be\u0995\u09c7\u0964 \u0986\u09ae\u09b0\u09be \u09a1\u09cb\u099c\/\u099f\u09be\u0987\u09ae\u09bf\u0982\/\u09aa\u09cd\u09b0\u09a4\u09bf\u0995\u09cd\u09b0\u09bf\u09af\u09bc\u09be \u09aa\u09b0\u09c0\u0995\u09cd\u09b7\u09be \u0995\u09b0\u099b\u09bf \u098f\u0996\u09a8 \u0986\u09ae\u09b0\u09be \u09b2\u09cd\u09af\u09be\u09ac\u09c7 \u09ab\u09bf\u09b0\u09c7 \u098f\u09b8\u09c7\u099b\u09bf \u098f\u09ac\u0982 \u09aa\u09b0\u09cd\u09af\u09be\u09aa\u09cd\u09a4 \u09aa\u09b0\u09bf\u09ae\u09be\u09a3\u09c7 \u0986\u09ae\u09be\u09a6\u09c7\u09b0 \u09a8\u09bf\u099c\u09b8\u09cd\u09ac AAV \u09a4\u09c8\u09b0\u09bf \u0995\u09b0\u09a4\u09c7 \u09aa\u09be\u09b0\u09bf<\/p>\n

\u09aa\u09cd\u09b0\u09b6\u09cd\u09a8\u0983<\/span><\/strong> \u09ae\u09be\u09b0\u09cd\u099f\u09bf\u09a8 \u09ac\u09be\u09b0\u09cd\u0997\u09cb \u09a5\u09c7\u0995\u09c7, \u09ad\u09be\u0987\u09b8\u09b0\u09cd\u09a1\u09ab\u09cb\u09b0\u09be\u09a8\u09cd\u09a1 \u0995\u09ae\u09bf\u099f\u09c7\u09a8 \u09ab\u09b0 \u09ab\u09b0\u09b8\u09cd\u0995\u09bf\u0982: \u0986\u09aa\u09a8\u09be\u09b0 Lmna \u09a8\u0995\u0986\u0989\u099f \u09aa\u09b0\u09c0\u0995\u09cd\u09b7\u09be\u09af\u09bc \u0985\u09a8\u09c1\u09aa\u09b8\u09cd\u09a5\u09bf\u09a4 \u09b2\u09cd\u09af\u09be\u09ae\u09bf\u09a8 A \u09ac\u09a8\u09be\u09ae \u09b2\u09cd\u09af\u09be\u09ae\u09bf\u09a8 C \u098f\u09b0 \u0986\u09aa\u09c7\u0995\u09cd\u09b7\u09bf\u0995 \u0985\u09ac\u09a6\u09be\u09a8 \u0995\u09c0 \u09ac\u09b2\u09c7 \u0986\u09aa\u09a8\u09bf \u09ae\u09a8\u09c7 \u0995\u09b0\u09c7\u09a8?
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\u09aa\u09cd\u09b0\u09b6\u09cd\u09a8\u0983 <\/span><\/strong>\u099f\u09ae \u09ae\u09bf\u09b8\u09cd\u099f\u09c7\u09b2\u09bf \u09a5\u09c7\u0995\u09c7: \u0995\u09b2\u09bf\u09a8: \u0986\u09aa\u09a8\u09bf \u0995\u09bf Lmna\/\u09b8\u09c2\u09b0\u09cd\u09af \u09aa\u09cd\u09b0\u09be\u09a3\u09c0\u09a6\u09c7\u09b0 \u09b8\u09c7\u09b2\u09c1\u09b2\u09be\u09b0 \u09b8\u09cd\u099f\u09cd\u09b0\u09c7\u09b8 \u09aa\u09cd\u09b0\u09a4\u09bf\u0995\u09cd\u09b0\u09bf\u09af\u09bc\u09be \u09aa\u09a5\u09c7\u09b0 \u09aa\u09b0\u09bf\u09ac\u09b0\u09cd\u09a4\u09a8 \u09a6\u09c7\u0996\u09c7\u099b\u09c7\u09a8?
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\u09aa\u09cd\u09b0\u09b6\u09cd\u09a8: \u09a1\u09c7\u09b2\u09ab\u09be\u0987\u09a8 \u09b2\u09cd\u09af\u09be\u09b0\u09bf\u0989 \u09a5\u09c7\u0995\u09c7: \u0986\u09aa\u09a8\u09bf \u0995\u09bf \u098f\u0987\u099a\u099c\u09bf\u09aa\u09bf\u098f\u09b8 \u09b0\u09cb\u0997\u09c0\u09a6\u09c7\u09b0 \u09a1\u09bf\u098f\u09a8\u098f\u09b8\u0987\u0989\u098f\u09a8\u09e7 \u09a6\u09bf\u09af\u09bc\u09c7 \u09b6\u09c1\u09a7\u09c1\u09ae\u09be\u09a4\u09cd\u09b0 \u09b9\u09be\u09b0\u09cd\u099f\u0995\u09c7 \u099f\u09be\u09b0\u09cd\u0997\u09c7\u099f \u0995\u09b0\u09be\u09b0 \u0995\u09a5\u09be \u09ad\u09be\u09ac\u09ac\u09c7\u09a8?
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[\/et_pb_toggle][et_pb_image src=\u201dhttps:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2020\/07\/Basso.Peraut-Family.jpg\u201d title_text=\u201dBasso.Peraut-Family\u201d align=\u201dcenter\u201d admin_label=\u201dfamilies\u201d _builder_version=\u201d4.16\u2033 _module_preset=\u201ddefault\u201d custom_margin=\u201d5px||15px||false|false\u201d global_colors_info=\u201d{}\u201d][\/et_pb_image][et_pb_toggle title=\u201d\u099a\u09cd\u09af\u09be\u099f \u09ae\u09a8\u09cd\u09a4\u09ac\u09cd\u09af \u09a5\u09c7\u0995\u09c7 \u098f\u0995\u099f\u09bf \u09a8\u09ae\u09c1\u09a8\u09be!\u201d open_toggle_background_color=\u201d#f7f7f7\u2033 closed_toggle_text_color=\u201d#ffffff\u201d closed_toggle_background_color=\u201d#00b2e2\u2033 icon_color=\u201d#ffc15e\u201d open_icon_color=\u201d#ffc15e\u201d admin_label=\u201d\u099a\u09cd\u09af\u09be\u099f \u09ae\u09a8\u09cd\u09a4\u09ac\u09cd\u09af \u09a5\u09c7\u0995\u09c7 \u09a8\u09ae\u09c1\u09a8\u09be \u09b8\u0982\u0997\u09cd\u09b0\u09b9!\u201d _builder_version=\u201d4.16\u2033 _module_preset=\u201ddefault\u201d title_text_color=\u201d#00b2e2\u2033 title_font=\u201d||||||\u201d background_color=\u201d#ffffff\u201d custom_margin=\u201d||25px\u201d custom_padding=\u201d|50px||50px||true\u201d border_width_all=\u201d0px\u201d global_colors_info=\u201d{}\u201d]<\/p>\n

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