{"id":1164,"date":"2016-07-11T16:06:53","date_gmt":"2016-07-11T16:06:53","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?p=1164"},"modified":"2020-12-14T12:08:06","modified_gmt":"2020-12-14T17:08:06","slug":"results-of-triple-drug-trial-for-progeria-published","status":"publish","type":"post","link":"https:\/\/www.progeriaresearch.org\/de\/2016\/07\/11\/results-of-triple-drug-trial-for-progeria-published\/","title":{"rendered":"Ergebnisse einer Dreifachstudie zu Medikamenten gegen Progerie ver\u00f6ffentlicht"},"content":{"rendered":"

[et_pb_section fb_built=\u201d1\u2033 _builder_version=\u201d3.22\u2033][et_pb_row _builder_version=\u201d3.25\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201dwiederholen\u201d][et_pb_column type=\u201d4_4\u2033 _builder_version=\u201d3.25\u2033 custom_padding=\u201d|||\u201d custom_padding__hover=\u201d|||\u201d][et_pb_text _builder_version=\u201d4.6.5\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201dwiederholen\u201d hover_enabled=\u201d0\u2033 sticky_enabled=\u201d0\u2033]<\/p>\n

PRF setzt seine aggressive Forschungsagenda fort<\/i><\/p>\n

Die Ergebnisse der Dreifachstudie zu Progeria wurden online in der Zeitschrift ver\u00f6ffentlicht Verkehr <\/i><\/a>am 11. Juli 2016**. Diese klinische Studie f\u00fcgte dem bereits erfolgreichen Medikament Lonafarnib zwei weitere Medikamente hinzu, Pravastatin und Zoledrons\u00e4ure. Die Studie wurde gemeinsam von PRF und dem National Heart, Lung and Blood Institute finanziert und von einem Expertenteam am Boston Children's Hospital, dem #1-Kinderkrankenhaus in den USA, durchgef\u00fchrt. Obwohl keine signifikanten Verbesserungen gegen\u00fcber der Lonafarnib-Einzeltherapie festgestellt wurden, identifiziert PRF weiterhin vielversprechende Medikamentenkandidaten, die Kindern mit Progerie ein l\u00e4ngeres und ges\u00fcnderes Leben erm\u00f6glichen k\u00f6nnten \u2013 wie unserem neuer Zwei-Medikamenten-Versuch<\/a>. In dieser brandneuen klinischen Studie wird Lonafarnib um das Medikament Everolimus erg\u00e4nzt, mit dem Ziel, die Gesundheit der Kinder besser zu verbessern als durch Lonafarnib allein. \u00a0klicken Sie hier<\/a> Weitere Einzelheiten finden Sie in unserer Pressemitteilung.<\/p>\n\n\n\n
\n

Meghan, 15 Jahre alt, Brennen, 7 Jahre alt, und Lindsay, 12 Jahre alt, nahmen an der Dreifachstudie teil. Dank Ihrer Unterst\u00fctzung hatten sie im Juni 2016 ihre ersten Besuche f\u00fcr die Zwei-Medikamenten-Studie.<\/p>\n

Alle drei Kinder nehmen seit mehreren Jahren Lonafarnib ein und erhalten nun zus\u00e4tzlich Everolimus in der Hoffnung, dass die beiden Medikamente in Kombination wirksamer sind.<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Um lebensrettende Behandlungen und ein Heilmittel f\u00fcr Progerie zu finden, hat PRF 4 klinische Studien am Boston Children's Hospital und 62 wissenschaftliche Studien finanziert. Wir sind begeistert, dass diese Studien gezeigt haben, dass Lonafarnib das Herz-Kreislauf-System der Kinder verbessert und ihre Lebenserwartung geringf\u00fcgig verl\u00e4ngert. Die drei Studienergebnisse zeigen, dass wir unsere aggressive Strategie fortsetzen m\u00fcssen, da die Suche nach wirksameren Behandlungen und letztendlich nach einem Heilmittel weitergeht.<\/p>\n

In einem begleitenden Leitartikel zu den Ergebnissen der dreifachen Studie schrieb der Direktor des National Institutes of Health und Studienautor Francis Collins, MD PhD: \u201e\u2026 es tauchen zus\u00e4tzliche therapeutische Optionen auf, und es gibt mehr Dynamik als je zuvor<\/i> in der Grundlagen- und klinischen Forschung.\u201c<\/p>\n

** Gordon et al., Klinische Studie mit den Protein-Farnesylierungsinhibitoren Lonafarnib, Pravastatin und Zoledrons\u00e4ure bei Kindern mit Hutchinson-Gilford-Progerie-Syndrom, Verkehr<\/i>, <\/b>10.1161\/ZIRKULATIONAHA.116.022188<\/b><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"

\t\t\t\tPRF setzt seine aggressive Forschungsagenda fort\t\t<\/p>","protected":false},"author":1,"featured_media":1168,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"

\u00a0<\/p>

Results of Triple Drug Trial for Progeria Published<\/b>\u00a0<\/i><\/h1>

PRF Continues Aggressive Research Agenda<\/i><\/p>

Results from the Progeria triple drug trial were published online by the journal Circulation <\/i><\/a>on July 11, 2016**. This clinical trial added two additional drugs, pravastatin and zoledronic acid, to the already successful drug lonafarnib. The trial was co-funded by PRF and The National Heart, Lung and Blood Institute, and conducted by an expert team at Boston Children\u2019s Hospital, the #1 children\u2019s hospital in the US.\u00a0 While no significant improvements were found over and above the lonafarnib single therapy, \u00a0PRF continues to identify promising drug candidates that may offer children with Progeria longer, healthier lives \u2013 like our new two-drug trial<\/a>.\u00a0 This brand new clinical trial adds the drug everolimus to lonafarnib, with the goal of improving the children\u2019s health more than lonafarnib alone. \u00a0Click here<\/a> for more details in our press release.<\/p>

Meghan, 15 years old, Brennen, 7 years old, and Lindsay, 12 years old, participated in the triple trial.\u00a0 They had their first visits for the 2-drug trial in June 2016, thanks to your support.<\/p>

All three children have been taking lonafarnib for several years, and are now adding everolimus in the hopes that the 2 drugs will be more effective together.<\/p><\/td><\/tr><\/tbody><\/table>

In an effort to identify life-saving treatments and the cure for Progeria, \u00a0PRF has funded 4 clinical trials at Boston Children\u2019s Hospital, and 62 scientific studies. We are thrilled these trials revealed that lonafarnib improves the children\u2019s cardiovascular system and modestly extends their lifespan.\u00a0 The triple trial results demonstrate the need for us to continue our aggressive strategy, as the search for more effective treatments, and ultimately the cure, continues.<\/p>

In an accompanying editorial about the triple trial results, National Institutes of Health Director and study author Francis Collins, MD PhD, wrote, \u201c\u2026 additional therapeutic options are emerging, and there is more momentum than ever<\/i> in the basic and clinical research communities.\u201d<\/p>

** Gordon, et. al., Clinical Trial of Protein Farnesylation Inhibitors Lonafarnib, Pravastatin and Zoledronic Acid in Children with Hutchinson-Gilford Progeria Syndrome, Circulation<\/i>, <\/b>10.1161\/CIRCULATIONAHA.116.022188<\/b><\/p>","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-1164","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"yoast_head":"\nResults of Triple Drug Trial for Progeria Published - The Progeria Research Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.progeriaresearch.org\/de\/2016\/07\/11\/results-of-triple-drug-trial-for-progeria-published\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Results of 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