{"id":12020,"date":"2021-01-06T15:09:42","date_gmt":"2021-01-06T20:09:42","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?p=12020"},"modified":"2022-11-14T17:14:57","modified_gmt":"2022-11-14T22:14:57","slug":"kicking-off-the-new-year-with-exciting-research-news","status":"publish","type":"post","link":"https:\/\/www.progeriaresearch.org\/de\/2021\/01\/06\/kicking-off-the-new-year-with-exciting-research-news\/","title":{"rendered":"Das neue Jahr beginnt mit spannenden Forschungsnachrichten!"},"content":{"rendered":"

[et_pb_section fb_built=\u201d1\u2033 _builder_version=\u201d4.16\u2033 custom_padding=\u201d0px|||||\u201d global_colors_info=\u201d{}\u201d][et_pb_row _builder_version=\u201d4.16\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201drepeat\u201d global_colors_info=\u201d{}\u201d][et_pb_column type=\u201d4_4\u2033 _builder_version=\u201d4.16\u2033 custom_padding=\u201d|||\u201d global_colors_info=\u201d{}\u201d custom_padding__hover=\u201d|||\u201d][et_pb_text admin_label=\u201dcontent base\u201d _builder_version=\u201d4.16\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201drepeat\u201d global_colors_info=\u201d{}\u201d]<\/p>\n

\"\"<\/p>\n

Frohes neues Jahr! Wir hoffen, dass alle gesunde und erholsame Feiertage hatten.<\/p>\n

Wir starten ins Jahr 2021 mit weitere spannende Forschungs-News<\/strong>Im Januar ver\u00f6ffentlichte das Wissenschaftsjournal Natur<\/em> ver\u00f6ffentlichte bahnbrechende Ergebnisse, die zeigen, dass die genetische Bearbeitung in einem Mausmodell von Progeria Korrektur der Mutation, die in vielen Zellen Progerie verursacht,<\/strong> verbesserte mehrere wesentliche Krankheitssymptome und dramatisch verl\u00e4ngerte Lebensdauer<\/strong> bei den M\u00e4usen.<\/p>\n

Die von PRF mitfinanzierte und von PRFs medizinischem Direktor Dr. Leslie Gordon mitverfasste Studie ergab, dass M\u00e4use mit einer einzigen Injektion eines Baseneditors, der so programmiert war, dass er die krankheitsverursachende Mutation korrigierte, 2,5-mal l\u00e4nger \u00fcberlebten als unbehandelte Progeria-Kontrollm\u00e4use und ein Alter erreichten, das dem Beginn des hohen Alters bei gesunden M\u00e4usen entspricht. Wichtig ist, dass behandelte M\u00e4use auch gesundes Gef\u00e4\u00dfgewebe behielten \u2013 eine bedeutende Entdeckung, da der Verlust der Gef\u00e4\u00dfintegrit\u00e4t ein Indikator f\u00fcr die Sterblichkeit bei Kindern mit Progeria ist.<\/p>\n

Die Studie wurde von einem weltweit t\u00e4tigen Experten f\u00fcr genetische Editierung geleitet, David Liu, PhD<\/a>, vom Broad Institute, MIT, Cambridge, MA, Jonathan Brown, Assistenzprofessor f\u00fcr Medizin in der Abteilung f\u00fcr Herz-Kreislaufmedizin an der Vanderbilt University, und Francis Collins, MD, PhD, Direktor der National Institutes of Health.<\/p>\n

[et_pb_text][et_pb_testimonial author=\u201dDr. Francis Collins\u201d job_title=\u201dDirektor der National Institutes of Health. \u201d admin_label=\u201dDr. Francis Collins\u201d _builder_version=\u201d4.16\u2033 _module_preset=\u201ddefault\u201d global_colors_info=\u201d{}\u201d]Diese dramatische Reaktion in unserem Progerie-Mausmodell zu sehen, ist eine der aufregendsten therapeutischen Entwicklungen, an denen ich in 40 Jahren als Arzt und Wissenschaftler beteiligt war\u201d, sagte Dr. Collins.
\n[et_pb_testimonial][et_pb_testimonial author=\u201dDavid Lui, PhD\u201d job_title=\u201dBroad Institute, MIT\u201d admin_label=\u201dDavid Lui, PhD\u201d _builder_version=\u201d4.16\u2033 _module_preset=\u201ddefault\u201d global_colors_info=\u201d{}\u201d]Vor f\u00fcnf Jahren waren wir noch mit der Entwicklung des allerersten Baseneditors besch\u00e4ftigt\u201d, sagte Dr. Liu. \u201cH\u00e4tte man mir damals gesagt, dass innerhalb von f\u00fcnf Jahren eine einzige Dosis eines Baseneditors Progerie bei einem Tier auf DNA-, RNA-, Protein-, Gef\u00e4\u00dfpathologie- und Lebensspannenebene behandeln k\u00f6nnte, h\u00e4tte ich das f\u00fcr unm\u00f6glich gehalten. Es ist ein wahrer Beweis f\u00fcr das Engagement des Teams, das diese Arbeit erm\u00f6glicht hat.\u2018.
\n[\/et_pb_testimonial][et_pb_text _builder_version=\u201d4.18.1\u2033 _module_preset=\u201ddefault\u201d hover_enabled=\u201d0\u2033 global_colors_info=\u201d{}\u201d sticky_enabled=\u201d0\u2033]<\/p>\n

Um diese Ergebnisse zu untersuchen, sind weitere pr\u00e4klinische Studien erforderlich, die hoffentlich eines Tages in eine klinische Studie m\u00fcnden werden. Wir freuen uns darauf, Sie \u00fcber diese spannende Entdeckung auf dem Laufenden zu halten, sobald weitere Fortschritte erzielt werden!<\/p>\n

Lesen Sie mehr \u00fcber diese spannende Neuigkeit Hier<\/a>.<\/p>\n

[\/et_pb_text][et_pb_text _builder_version=\u201d4.18.1\u2033 _module_preset=\u201ddefault\u201d hover_enabled=\u201d0\u2033 global_colors_info=\u201d{}\u201d sticky_enabled=\u201d0\u2033]<\/p>\n

\n

Zu Beginn des Jahres 2021 sind wir dankbar f\u00fcr Partner wie SIE, die solche Fortschritte erm\u00f6glichen.<\/p>\n

Letztes Jahr allein<\/em>, Die Progeria Research Foundation:<\/strong><\/span><\/p>\n

\n

    \n
  • Ein wichtiger Meilenstein wurde mit der ersten von der FDA zugelassenen Behandlung gegen Progerie, Lonafarnib, erreicht;<\/li>\n
  • Brachte Kinder mit Progerie aus der ganzen Welt f\u00fcr die von der PRF finanzierte klinische Studie ins Boston Children's Hospital (als Reisen aufgrund von COVID-19 erlaubt waren);<\/li>\n
  • Wir hielten unsere 10. Internationaler wissenschaftlicher Workshop zu Progerie<\/em>, bei dem wir eine Rekordzahl von 370 Teilnehmern aus 30 L\u00e4ndern bei unserem allerersten webbasierten wissenschaftlichen Meeting zusammenbrachten;<\/li>\n
  • Machen Sie ernsthaft mit unseren wichtigsten Programmaktivit\u00e4ten weiter, die uns zu Behandlungen und der zuk\u00fcnftigen Heilung f\u00fchren werden!<\/li>\n<\/ul>\n

    [\/et_pb_text][et_pb_text _builder_version=\u201d4.18.1\u2033 _module_preset=\u201ddefault\u201d hover_enabled=\u201d0\u2033 global_colors_info=\u201d{}\u201d sticky_enabled=\u201d0\u2033]<\/p>\n

    \n

    Koblan LW, Erdos MR, Wilson C, Cabral\u00a0<\/sup>WA, Levy JM, Iong, ZM, Tavarez\u00a0<\/sup>UL, Davison L, Gete YG, Mao X, Newby\u00a0<\/sup>GA, Doherty SP, Narisu N, Sheng Q, Krilow C, Lin CY,\u00a0Gordon<\/b>\u00a0LB, Cao K, Collins FS, Brown JD, Liu\u00a0DR.\u00a0<\/span>In Vivo\u00a0<\/i>Adenin-Basen-Editierung rettet Hutchinson-Gilford-Progerie-Syndrom\u00a0<\/b>Natur. 6. Januar 2021<\/span><\/p>\n

    [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"

    Im Januar ver\u00f6ffentlichte das Wissenschaftsjournal Natur<\/i> ver\u00f6ffentlichte bahnbrechende Ergebnisse, die zeigen, dass die genetische Bearbeitung in einem Mausmodell von Progerie die Mutation korrigierte, die in vielen Zellen Progerie verursacht, mehrere wichtige Krankheitssymptome verbesserte und die Lebensdauer der M\u00e4use dramatisch erh\u00f6hte.<\/p>","protected":false},"author":2,"featured_media":12024,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2,1],"tags":[],"class_list":["post-12020","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-uncategorized"],"yoast_head":"\nKicking off the New Year with exciting research news! - The Progeria Research Foundation<\/title>\n<meta name=\"robots\" content=\"index, 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