{"id":16611,"date":"2023-03-15T10:12:02","date_gmt":"2023-03-15T14:12:02","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?p=16611"},"modified":"2025-02-15T17:46:23","modified_gmt":"2025-02-15T22:46:23","slug":"progerinbiomarker","status":"publish","type":"post","link":"https:\/\/www.progeriaresearch.org\/de\/2023\/03\/15\/progerinbiomarker\/","title":{"rendered":"Spannende Forschungsmeilensteine in der Behandlungsbewertung und Lebensverl\u00e4ngerung!"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.16″ custom_padding=”0px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_padding=”||5px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.24.0″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”]<\/p>\n

Wir freuen uns, Ihnen zwei spannende Forschungsupdates pr\u00e4sentieren zu k\u00f6nnen, die heute online im weltweit wichtigsten Fachjournal f\u00fcr Herz-Kreislauf-Erkrankungen ver\u00f6ffentlicht wurden. Verkehr (1)<\/a><\/em>:<\/h5>\n

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Biomarker bei Progerie<\/u><\/strong><\/span><\/p>\n

Ein Team unter der Leitung von PRF-Mitbegr\u00fcnder und medizinischer Direktor Dr. Leslie Gordon hat eine neue Methode zur Messung von Progerin entwickelt, dem toxischen Protein, das Progerie verursacht. Mit der Entdeckung dieses Biomarkers, der Blutplasma zur Messung des Progerinspiegels verwendet, Forscher k\u00f6nnen nach einer k\u00fcrzeren Zeitspanne verstehen, wie sich Behandlungen auf Teilnehmer klinischer Studien auswirken<\/strong> und an mehreren Punkten im Verlauf jeder klinischen Studie.<\/p>\n

Dieser Test kann den Prozess klinischer Studien optimieren, indem er Bereitstellung fr\u00fchzeitiger Informationen \u00fcber die Wirksamkeit getesteter Behandlungen<\/strong>, als Auftakt zu anderen klinischen Tests wie Gewichtszunahme, dermatologischen Ver\u00e4nderungen, Gelenkkontraktur und -funktion usw., die alle viel mehr Zeit ben\u00f6tigen, um sich zu manifestieren. Diese klinischen Merkmale der Progerie sind wichtige l\u00e4ngerfristige Indikatoren f\u00fcr Behandlungseffekte, die jetzt durch die fr\u00fcher in der Therapie gemessenen Progerinwerte erg\u00e4nzt werden. Wir k\u00f6nnen jetzt m\u00f6glicherweise bereits vier Monate nach Beginn der Behandlung den Behandlungsnutzen erkennen oder eine Behandlung, die dem Studienteilnehmer m\u00f6glicherweise nicht n\u00fctzt, abbrechen, um unn\u00f6tige Nebenwirkungen zu vermeiden.<\/p>\n

Noch l\u00e4ngeres Leben mit Lonafarnib<\/u><\/span><\/strong><\/p>\n

Diese neue und innovative Methode zur Messung von Progerin beschleunigt nicht nur die Entdeckung zuk\u00fcnftiger Behandlungsmethoden und Heilmittel, sondern weist auch darauf hin, dass die Der langfristige Nutzen von Lonafarnib f\u00fcr Kinder mit Progerie ist gr\u00f6\u00dfer als bisher angenommen<\/strong>.<\/p>\n

Studiendaten zeigen, dass niedrigere Progerinwerte im Blut einen \u00dcberlebensvorteil bedeuten: Je l\u00e4nger jemand mit Progerie Lonafarnib einnahm, desto gr\u00f6\u00dfer war der \u00dcberlebensvorteil durch die Therapie. Die Progerinwerte sanken w\u00e4hrend der Einnahmedauer des Medikaments um etwa 30-60%, und die Lebenserwartung von Patienten, die \u00fcber 10 Jahre lang behandelt wurden, stieg im Durchschnitt um 4,5 Jahre. Das ist mehr als 30% Anstieg der durchschnittlichen Lebenserwartung, von 14,5 Jahren auf fast 20 Jahre<\/strong>!<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_button button_url=”https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2023\/03\/Progerin-Plasma-Biomarker-press-release-FINAL.pdf” button_text=”To learn more, see our press release here” button_alignment=”center” admin_label=”biomarker pdf” _builder_version=”4.19.5″ _module_preset=”default” button_text_color=”#FFFFFF” button_bg_color=”#00B2E2″ button_border_width=”0px” button_border_color=”#00B2E2″ background_layout=”dark” global_colors_info=”{}”][\/et_pb_button][et_pb_text _builder_version=”4.19.5″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

\u201eEine der bemerkenswertesten Geschichten, die je in diesem Podcast erz\u00e4hlt wurden\u201c
<\/strong>\u2013 Dr. Carolyn Lam, weltbekannte Herzspezialistin und Moderatorin des Podcasts Zirkulation auf der Flucht, <\/em>\u00fcber die Reise, die zu diesen spannenden Erkenntnissen f\u00fchrte. <\/em>H\u00f6ren Sie das ganze Interview<\/strong> \u00fcber die tiefgreifende Wirkung dieser Studie direkt von Dr. Gordon. H\u00f6ren Sie Hier<\/strong><\/a> (<\/a>ab 6:41).<\/p>\n

[\/et_pb_text][et_pb_button button_url=”https:\/\/circulation.libsyn.com\/circulation-june-6-2023-issue” button_text=”Hear Dr. Leslie Gordon on Circulation on the Run podcast” button_alignment=”center” admin_label=”circulation podcast” _builder_version=”4.19.5″ _module_preset=”default” button_text_color=”#FFFFFF” button_bg_color=”#00B2E2″ button_border_width=”0px” button_border_color=”#00B2E2″ background_layout=”dark” global_colors_info=”{}”][\/et_pb_button][et_pb_text _builder_version=”4.19.5″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

Und im Juni zwei Leitartikel (2) <\/a>Und (3)<\/a> erschienen in Verkehr <\/i>Dies unterstreicht die entscheidende Bedeutung dieses Biomarkers f\u00fcr die Weiterentwicklung der Behandlung und Heilung von Kindern mit Progerie und f\u00fcr ein besseres Verst\u00e4ndnis des Alterns.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”papers” module_id=”1″ _builder_version=”4.19.5″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”]<\/p>\n

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(1) Gordon, LB, Norris, W., Hamren, S., et al<\/em>. Plasma-Progerin bei Patienten mit Hutchinson-Gilford-Progerie-Syndrom: Entwicklung eines Immunassays und klinische Bewertung. Verkehr<\/em>, 2023<\/p>\n

(2) Fortschreiten von Herzanomalien beim Hutchinson-Gilford-Progerie-Syndrom: Eine prospektive L\u00e4ngsschnittstudie.<\/a>
Olsen FJ, Gordon LB, Smoot L, Kleinman ME, Gerhard-Herman M, Hegde SM, Mukundan S, Mahoney T, Massaro J, Ha S, Prakash A.
Verkehr<\/em>. 6. Juni 2023;147(23):1782-1784. doi: 10.1161\/CIRCULATIONAHA.123.064370. Epub 5. Juni 2023.<\/p>\n

(3) Leicht verf\u00fcgbare Tools zum Erkennen von Progerin und des Fortschreitens der Herzerkrankung beim Hutchinson-Gilford-Progerie-Syndrom. <\/a>
Eriksson M, Haugaa K, Rev\u00eachon G.
Verkehr<\/em>. 6. Juni 2023;147(23):1745-1747. doi: 10.1161\/CIRCULATIONAHA.123.064765. Epub 5. Juni 2023.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"

Unser Forschungsteam hat eine wichtige neue Methode zur Messung von Progerin entdeckt, dem toxischen Protein, das Progerie verursacht. Mit dieser Entdeckung stellten die Wissenschaftler auch fest, dass der langfristige Nutzen von Lonafarnib f\u00fcr Kinder mit Progerie gr\u00f6\u00dfer ist als wir dachten.
\nWas bedeuten diese beiden Erkenntnisse f\u00fcr die Progerie-Gemeinschaft? <\/p>","protected":false},"author":2,"featured_media":16614,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2,1],"tags":[],"class_list":["post-16611","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-uncategorized"],"yoast_head":"\nProgerin Biomarker | The Progeria Research Foundation<\/title>\n<meta name=\"description\" content=\"Our research team has discovered a vital new way to measure progerin, the toxic protein that causes Progeria. With this discovery, scientists also found that the long-term benefit of lonafarnib for children with Progeria is greater than we thought. What do these two findings mean for the Progeria community? 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