{"id":2107,"date":"2006-05-16T20:16:46","date_gmt":"2006-05-16T20:16:46","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?p=2107"},"modified":"2020-12-09T15:32:43","modified_gmt":"2020-12-09T20:32:43","slug":"prf-funded-studies-provide-support-for-drug-trial","status":"publish","type":"post","link":"https:\/\/www.progeriaresearch.org\/de\/2006\/05\/16\/prf-funded-studies-provide-support-for-drug-trial\/","title":{"rendered":"PRF-finanzierte Studien unterst\u00fctzen Arzneimitteltests"},"content":{"rendered":"

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PRF erreicht $1,4 der $2 Millionen, die zur Finanzierung des Versuchs ben\u00f6tigt werden!<\/u> Im Juli ver\u00f6ffentlichten die UCLA-Forscher Loren Fong und Stephen Young Ergebnisse von PRF-finanzierten Studien mit Progeria-M\u00e4usen, in denen eine m\u00f6gliche medikament\u00f6se Behandlung f\u00fcr Kinder mit Progeria getestet wurde. Das FTI-Medikament verbesserte einige Anzeichen der Krankheit bei den M\u00e4usen! Diese und andere aktuelle Studien haben den Weg f\u00fcr PRF geebnet, eine klinische Studie mit den Kindern zu beginnen. Nehmen Sie an unserem Kampagne f\u00fcr klinische Studien<\/a> und helfen Sie, den Prozess zu erm\u00f6glichen!<\/p>\n

\"\"20. Juli 2006: PRF-finanzierte Forscher treiben die Progerieforschung auf unserer Suche nach einem Heilmittel weiter voran. Ver\u00f6ffentlicht in der heutigen Online-Ausgabe der Zeitschrift f\u00fcr klinische Untersuchungen<\/em>Die Ergebnisse unterst\u00fctzen den Beginn klinischer Studien am Menschen mit dem Krebsmedikament Farnesyltransferase-Hemmer (FTI).<\/div>\n
\u00a0<\/div>\n
PRF finanziert eine klinische Arzneimittelstudie f\u00fcr Progerie<\/a><\/u>, die am 7. Mai begann. Im Rahmen der Studie werden die Kinder mit einem Medikament namens FTI behandelt. Dies ist ein kritischer Zeitpunkt, um PRF zu helfen, da wir Geld f\u00fcr die Finanzierung der Studie sammeln.<\/div>\n
klicken Sie hier<\/a> um herauszufinden, wie Sie helfen k\u00f6nnen.<\/div>\n
\u00a0<\/div>\n
Ausz\u00fcge aus dem Zeitschrift f\u00fcr klinische Untersuchungen:<\/em><\/div>\n
\u00a0<\/div>\n
Krebsmedikament lindert Progerie: Neues Mausmodell kommt der menschlichen Krankheit am n\u00e4chsten<\/u><\/strong><\/div>\n
\u00a0<\/div>\n
Mithilfe ihres neuen Progerie-Mausmodells stellten die Forscher der UCLA fest, dass ein experimentelles Medikament, ein sogenannter Farnesyltransferase-Hemmer, die Knochendichte verbesserte, Knochenbr\u00fcche reduzierte, den Krankheitsausbruch verz\u00f6gerte und bei der Gewichtszunahme half. Die Wirkung des Medikaments war dramatischer als in fr\u00fcheren Studien mit anderen Tiermodellen. Dieses neue Mausmodell spiegelt den genetischen Defekt, der viele F\u00e4lle von Progerie beim Menschen verursacht, sehr gut wider.<\/div>\n
Diese Erkenntnisse werden Forschern helfen, Arzneimitteltherapien f\u00fcr Kinder mit Progerie gezielter zu entwickeln und zu einem besseren Verst\u00e4ndnis der Krankheitsmechanismen zu f\u00fchren. Die Erkenntnisse der UCLA haben es m\u00f6glich gemacht, klinische Studien am Menschen in Betracht zu ziehen.<\/div>\n
\u00a0<\/div>\n
Zu den UCLA-Forschern geh\u00f6ren Dr. Shao H. Yang, Loren G. Fong, Ph.D. und Dr. Stephen G. Young von der David Geffen School of Medicine an der UCLA.<\/div>\n

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[et_pb_section fb_built=”1″ _builder_version=”3.22″][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.6.5″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” hover_enabled=”0″ sticky_enabled=”0″] PRF Reaches $1.4 of the $2 Million Needed to Fund Trial! In July, UCLA researchers Loren Fong and Stephen Young published findings from PRF-funded studies with Progeria mice, testing a potential drug treatment for children with Progeria. The […]<\/p>","protected":false},"author":1,"featured_media":2108,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"

[vc_custom_heading text=\"PRF-Funded Studies Provide Support for Drug Trial\" font_container=\"tag:h1|text_align:left\" use_theme_fonts=\"yes\"]<\/p>

PRF Reaches $1.4 of the $2 Million Needed to Fund Trial!<\/u> In July, UCLA researchers Loren Fong and Stephen Young published findings from PRF-funded studies with Progeria mice, testing a potential drug treatment for children with Progeria. The FTI drug improved some signs of the disease in the mice! These and other recent studies have paved the way for PRF to begin a clinical trial with the children. Join our Clinical Trial Campaign<\/a> and help make the trial happen!<\/p><\/div>

\"\"July 20, 2006:\u00a0 PRF-funded researchers continue to drive Progeria research to new levels of progress in our quest for the cure.\u00a0Published in today's online edition of the Journal of Clinical Investigation<\/em>, the findings support the start of human clinical trials with the cancer drug, farnesyltransferase inhibitor (FTI).<\/div>
\u00a0<\/div>
PRF is funding a clinical drug trial for Progeria<\/a><\/u>, which began on May 7th. The trial is treating the children with a drug called FTI. This is a critical time to help PRF, as we are raising money to fund the trial.<\/div>
Click here<\/a> to find out how you can help.<\/div>
\u00a0<\/div>
Excerpts taken from the Journal of Clinical Investigation:<\/em><\/div>
\u00a0<\/div>
Cancer Drug Improves Progeria: New Mouse Model Closest to Disease in Humans<\/u><\/strong><\/div>
\u00a0<\/div>
Using their new mouse model of progeria, UCLA Investigators found that an experimental drug, called a farnesyltransferase inhibitor, improved bone density, reduced bone fractures, delayed the onset of the disease, and helped with weight gain. The effects of the drug were more dramatic than in previous studies using other animal models. This new mouse model closely mirrors the genetic defect causing many cases of progeria in humans.<\/div>
These findings will help researchers target drug therapies for children with progeria and lead to a better understanding of mechanisms of disease. The UCLA findings have made it feasible to consider human clinical trials.<\/div>
\u00a0<\/div>
UCLA researchers include Dr. Shao H. Yang, Loren G. Fong, Ph.D., and Dr. Stephen G. Young of the David Geffen School of Medicine at UCLA.<\/div>","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-2107","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"yoast_head":"\nPRF-Funded Studies Provide Support for Drug Trial - The Progeria Research Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.progeriaresearch.org\/de\/2006\/05\/16\/prf-funded-studies-provide-support-for-drug-trial\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PRF-Funded Studies Provide Support for Drug Trial - The Progeria Research Foundation\" \/>\n<meta property=\"og:description\" content=\"[et_pb_section fb_built=”1″ _builder_version=”3.22″][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.6.5″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” hover_enabled=”0″ sticky_enabled=”0″] PRF Reaches $1.4 of the $2 Million Needed to Fund Trial! 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