{"id":16611,"date":"2023-03-15T10:12:02","date_gmt":"2023-03-15T14:12:02","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?p=16611"},"modified":"2025-02-15T17:46:23","modified_gmt":"2025-02-15T22:46:23","slug":"progerinbiomarker","status":"publish","type":"post","link":"https:\/\/www.progeriaresearch.org\/es\/2023\/03\/15\/progerinbiomarker\/","title":{"rendered":"\u00a1Interesantes hitos de investigaci\u00f3n en la evaluaci\u00f3n del tratamiento y la extensi\u00f3n de la vida!"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.16″ custom_padding=”0px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_padding=”||5px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.24.0″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”]<\/p>\n

Nos complace compartir con ustedes dos emocionantes actualizaciones de investigaci\u00f3n, publicadas en l\u00ednea hoy en la revista cardiovascular m\u00e1s importante del mundo, Circulaci\u00f3n (1)<\/a><\/em>:<\/h5>\n

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Biomarcador en la progeria<\/u><\/strong><\/span><\/p>\n

Un equipo dirigido por el cofundador y director m\u00e9dico de PRF, el Dr. Leslie Gordon, ha desarrollado una nueva forma de medir la progerina, la prote\u00edna t\u00f3xica que causa la progeria. Con el descubrimiento de este biomarcador, que utiliza el plasma sangu\u00edneo para medir los niveles de progerina, Los investigadores pueden comprender c\u00f3mo los tratamientos afectan a los participantes de los ensayos cl\u00ednicos despu\u00e9s de un per\u00edodo de tiempo m\u00e1s corto.<\/strong> y en m\u00faltiples puntos a lo largo de cada ensayo cl\u00ednico.<\/p>\n

Esta prueba puede optimizar el proceso de ensayo cl\u00ednico al Proporcionar informaci\u00f3n temprana sobre la eficacia de los tratamientos que se est\u00e1n probando.<\/strong>, como una introducci\u00f3n a otras pruebas cl\u00ednicas como aumento de peso, cambios dermatol\u00f3gicos, contractura y funci\u00f3n de las articulaciones, etc., todas las cuales requieren mucho m\u00e1s tiempo para manifestarse. Estas caracter\u00edsticas cl\u00ednicas de la progeria son importantes medidas a largo plazo de los efectos del tratamiento que ahora se complementan con los niveles de progerina medidos en etapas anteriores de la terapia. Ahora podemos ser capaces de comprender los beneficios del tratamiento tan pronto como cuatro meses despu\u00e9s de comenzar el tratamiento, o detener un tratamiento que puede no beneficiar al participante del ensayo, para evitar efectos secundarios innecesarios.<\/p>\n

Vidas a\u00fan m\u00e1s largas con lonafarnib<\/u><\/span><\/strong><\/p>\n

Adem\u00e1s de acelerar los descubrimientos futuros sobre tratamientos y curas, esta nueva e innovadora forma de medir la progerina indica que la El beneficio a largo plazo del lonafarnib para ni\u00f1os con progeria es mayor que lo determinado previamente<\/strong>.<\/p>\n

Los datos del estudio indican que los niveles m\u00e1s bajos de progerina en la sangre reflejan un beneficio en la supervivencia: cuanto m\u00e1s tiempo una persona con progeria permanece en tratamiento con lonafarnib, mayor es el beneficio en la supervivencia de estar en terapia. Los niveles de progerina disminuyeron en aproximadamente 30-60% durante el tiempo que se tom\u00f3 el medicamento, y la expectativa de vida para los pacientes en tratamiento durante m\u00e1s de 10 a\u00f1os aumenta en un promedio de 4,5 a\u00f1os. Un aumento de m\u00e1s del 30% en la esperanza de vida media, de 14,5 a\u00f1os a casi 20 a\u00f1os de edad<\/strong>!<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_button button_url=”https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2023\/03\/Progerin-Plasma-Biomarker-press-release-FINAL.pdf” button_text=”To learn more, see our press release here” button_alignment=”center” admin_label=”biomarker pdf” _builder_version=”4.19.5″ _module_preset=”default” button_text_color=”#FFFFFF” button_bg_color=”#00B2E2″ button_border_width=”0px” button_border_color=”#00B2E2″ background_layout=”dark” global_colors_info=”{}”][\/et_pb_button][et_pb_text _builder_version=”4.19.5″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

\u201cUna de las historias m\u00e1s notables jam\u00e1s compartidas en este podcast\u201d
<\/strong>\u2013 Dra. Carolyn Lam, cardi\u00f3loga de renombre mundial y presentadora del podcast Circulaci\u00f3n en marcha, <\/em>en el viaje que condujo a estos emocionantes hallazgos. <\/em>Escucha la entrevista completa<\/strong> sobre el profundo impacto de este estudio directamente del Dr. Gordon. Escuche aqu\u00ed<\/strong><\/a> (<\/a>a partir de las 6:41).<\/p>\n

[\/et_pb_text][et_pb_button button_url=”https:\/\/circulation.libsyn.com\/circulation-june-6-2023-issue” button_text=”Hear Dr. Leslie Gordon on Circulation on the Run podcast” button_alignment=”center” admin_label=”circulation podcast” _builder_version=”4.19.5″ _module_preset=”default” button_text_color=”#FFFFFF” button_bg_color=”#00B2E2″ button_border_width=”0px” button_border_color=”#00B2E2″ background_layout=”dark” global_colors_info=”{}”][\/et_pb_button][et_pb_text _builder_version=”4.19.5″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

Y en junio, dos art\u00edculos editoriales (2) <\/a>y (3)<\/a> fueron publicados en Circulaci\u00f3n <\/i>destacando la importancia cr\u00edtica de este biomarcador para avanzar en los tratamientos y la cura de los ni\u00f1os con progeria y para comprender mejor el envejecimiento.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”papers” module_id=”1″ _builder_version=”4.19.5″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”]<\/p>\n

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\n

(1) Gordon, LB, Norris, W., Hamren, S., y otros<\/em>Progerina plasm\u00e1tica en pacientes con s\u00edndrome de progeria de Hutchinson-Gilford: desarrollo de inmunoensayo y evaluaci\u00f3n cl\u00ednica. Circulaci\u00f3n<\/em>, 2023<\/p>\n

(2) Progresi\u00f3n de anomal\u00edas card\u00edacas en el s\u00edndrome de progeria de Hutchinson-Gilford: un estudio longitudinal prospectivo.<\/a>
Olsen FJ, Gordon LB, Smoot L, Kleinman ME, Gerhard-Herman M, Hegde SM, Mukundan S, Mahoney T, Massaro J, Ha S, Prakash A.
Circulaci\u00f3n<\/em>. 6 de junio de 2023;147(23):1782-1784. doi: 10.1161\/CIRCULATIONAHA.123.064370. Publicaci\u00f3n electr\u00f3nica 5 de junio de 2023.<\/p>\n

(3) Herramientas f\u00e1cilmente disponibles para detectar progerina y progresi\u00f3n de la enfermedad card\u00edaca en el s\u00edndrome de progeria de Hutchinson-Gilford. <\/a>
Eriksson M, Haugaa K, Rev\u00eachon G.
Circulaci\u00f3n<\/em>. 6 de junio de 2023;147(23):1745-1747. doi: 10.1161\/CIRCULATIONAHA.123.064765. Publicaci\u00f3n electr\u00f3nica 5 de junio de 2023.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"

Nuestro equipo de investigaci\u00f3n ha descubierto una nueva forma vital de medir la progerina, la prote\u00edna t\u00f3xica que causa la progeria. Con este descubrimiento, los cient\u00edficos tambi\u00e9n descubrieron que el beneficio a largo plazo del lonafarnib para los ni\u00f1os con progeria es mayor de lo que pens\u00e1bamos.
\n\u00bfQu\u00e9 significan estos dos hallazgos para la comunidad de progeria? <\/p>","protected":false},"author":2,"featured_media":16614,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2,1],"tags":[],"class_list":["post-16611","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-uncategorized"],"yoast_head":"\nProgerin Biomarker | The Progeria Research Foundation<\/title>\n<meta name=\"description\" content=\"Our research team has discovered a vital new way to measure progerin, the toxic protein that causes Progeria. With this discovery, scientists also found that the long-term benefit of lonafarnib for children with Progeria is greater than we thought. What do these two findings mean for the Progeria community? 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