{"id":2128,"date":"2005-05-16T20:41:26","date_gmt":"2005-05-16T20:41:26","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?p=2128"},"modified":"2020-12-09T11:08:36","modified_gmt":"2020-12-09T16:08:36","slug":"exciting-news-on-potential-drug-treatments","status":"publish","type":"post","link":"https:\/\/www.progeriaresearch.org\/es\/2005\/05\/16\/exciting-news-on-potential-drug-treatments\/","title":{"rendered":"Noticias interesantes sobre posibles tratamientos farmacol\u00f3gicos"},"content":{"rendered":"

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\n

Agosto de 2005 \u2013 febrero de 2006: Los investigadores han publicado estudios que respaldan un posible tratamiento farmacol\u00f3gico para ni\u00f1os con progeria. Los inhibidores de la farnesiltransferasa (FTI), desarrollados originalmente para el c\u00e1ncer, son capaces de revertir las dram\u00e1ticas anomal\u00edas de la estructura nuclear que son el sello distintivo de las c\u00e9lulas de los ni\u00f1os con progeria.<\/p>\n

A continuaci\u00f3n se presentan algunas respuestas a preguntas frecuentes sobre FTI y estos hallazgos recientes.<\/a><\/strong><\/p>\n

Del laboratorio de Susan Michaelis en la Facultad de Medicina de la Universidad Johns Hopkins y la Universidad de Seattle. Primera autora: Monica Mallampalli.<\/a> PRF financi\u00f3 este estudio.<\/em> haga clic aqu\u00ed<\/a> Para el articulo \"<\/p>\n

Del laboratorio del Dr. Thomas Glover en la Universidad de Michigan.<\/a> Primer autor: Michael W. Glynn. PRF financi\u00f3 este estudio.<\/em> haga clic aqu\u00ed<\/a> Para el articulo \"<\/p>\n

Del laboratorio del Dr. Francis Collins en el Instituto Nacional de Investigaci\u00f3n del Genoma Humano: Primer autor: Brian Capell.<\/a> Autor adicional: Director m\u00e9dico de PRF, Dr. Leslie Gordon<\/em><\/p>\n

Capell BC, Erdos MR, Madigan JP, Fiordalisi JJ, Varga R, Conneely KN, et al. La inhibici\u00f3n de la farnesilaci\u00f3n de la progerina previene la formaci\u00f3n de ampollas nucleares caracter\u00edsticas del s\u00edndrome de progeria de Hutchinson-Gilford.<\/em> Proc Natl Acad Sci Estados Unidos 2005;102(36):12879-84.<\/p>\n

Del laboratorio de los Dres. Loren Fong y Steven Young en UCLA.<\/a> PRF ayud\u00f3 a financiar este estudio.<\/em><\/p>\n

Fong LG, Frost D, Meta M, Qiao X, Yang SH, Coffinier C, et al. Un inhibidor de la prote\u00edna farnesiltransferasa mejora la enfermedad en un modelo de rat\u00f3n de progeria.<\/em> Ciencia 2006;311(5767):1621-3.<\/p>\n

\u00c9stos son s\u00f3lo algunos de los muchos medios de comunicaci\u00f3n que han cubierto esta historia:<\/strong><\/p>\n

ABCNEWS.COM<\/strong>
Los medicamentos contra el c\u00e1ncer podr\u00edan combatir una enfermedad rara de r\u00e1pido envejecimiento: 29 de septiembre de 2005 (art\u00edculo ya no disponible)
Los Angeles Times<\/strong>
Una investigaci\u00f3n demuestra que los medicamentos podr\u00edan bloquear las enfermedades que provocan el envejecimiento prematuro (art\u00edculo ya no disponible)
Forbes <\/strong>
Los medicamentos contra el c\u00e1ncer podr\u00edan combatir enfermedades que provocan un envejecimiento r\u00e1pido (art\u00edculo ya no disponible)
REUTERS<\/strong>
Los medicamentos contra el c\u00e1ncer podr\u00edan tratar el s\u00edndrome del envejecimiento en los ni\u00f1os (art\u00edculo ya no disponible)
SITIO DE NOTICIAS DE SALUD.COM<\/strong>
C\u00f3mo bloquear el s\u00edndrome de envejecimiento prematuro con f\u00e1rmacos contra el c\u00e1ncer (art\u00edculo ya no disponible)<\/p>\n<\/div>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”3.22″][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.6.5″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” hover_enabled=”0″ sticky_enabled=”0″] August 2005 \u2013February 2006: Researchers have published studies that support a potential drug treatment for children with Progeria. Farnesyltransferase inhibitors (FTIs), originally developed for cancer, are capable of reversing the dramatic nuclear structure abnormalities that are the hallmark […]<\/p>","protected":false},"author":1,"featured_media":2043,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"

[vc_custom_heading text=\"Exciting News on Potential Drug Treatments\" font_container=\"tag:h1|text_align:left\" use_theme_fonts=\"yes\"]<\/p>

August 2005 \u2013February 2006: Researchers have published studies that support a potential drug treatment for children with Progeria. Farnesyltransferase inhibitors (FTIs), originally developed for cancer, are capable of reversing the dramatic nuclear structure abnormalities that are the hallmark of cells from children with Progeria.<\/p>

Here are some answers to Frequently Asked Questions about FTI's and these recent findings<\/a><\/strong><\/p>

From the lab of Susan Michaelis at Johns Hopkins University School of Medicine and the University of Seattle. First author: Monica Mallampalli.<\/a> PRF funded this study.<\/em> Click here<\/a> for the article \"<\/p>

From the lab of Dr. Thomas Glover at the University of Michigan.<\/a> First author: Michael W. Glynn. PRF funded this study.<\/em> Click here<\/a> for the article \"<\/p>

From the lab of Dr. Francis Collins at the National Human Genome Research Institute: First author: Brian Capell.<\/a> Additional author: PRF's Medical Director Dr. Leslie Gordon<\/em><\/p>

Capell BC, Erdos MR, Madigan JP, Fiordalisi JJ, Varga R, Conneely KN, et al. Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome.<\/em> Proc Natl Acad Sci U S A 2005;102(36):12879-84.<\/p>

From the lab of Drs. Loren Fong and Steven Young at UCLA.<\/a> PRF helped fund this study.<\/em><\/p>

Fong LG, Frost D, Meta M, Qiao X, Yang SH, Coffinier C, et al. A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria.<\/em> Science 2006;311(5767):1621-3.<\/p>

Here are just a few of the many media outlets that have covered this story:<\/strong><\/p>

ABCNEWS.COM<\/strong>
Cancer Drugs May Fight Rare Rapid-Aging Disease: Sept.29, 2005<\/a> (article no longer available)
LA TIMES<\/strong>
Research Shows Drugs Could Block Early-Aging Disease<\/a>
FORBES <\/strong>
Cancer Drugs May Fight Rapid-Aging Disease<\/a>\u00a0(article no longer available)
REUTERS<\/strong>
Cancer Drugs May Treat Aging Syndrome in Children<\/a> (article no longer available)
HEALTHNEWSDIGEST.COM<\/strong>
Blocking a Premature Aging Syndrome with Anticancer Drugs<\/a>\u00a0(article no longer available)<\/p>
You will need the Adobe Acrobat Plugin to view and print forms. 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