{"id":2135,"date":"2005-05-16T20:48:59","date_gmt":"2005-05-16T20:48:59","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?p=2135"},"modified":"2020-12-09T10:24:44","modified_gmt":"2020-12-09T15:24:44","slug":"reversal-of-the-cellular-phenotype-in-the-premature-aging-disease-hgps","status":"publish","type":"post","link":"https:\/\/www.progeriaresearch.org\/es\/2005\/05\/16\/reversal-of-the-cellular-phenotype-in-the-premature-aging-disease-hgps\/","title":{"rendered":"Reversi\u00f3n del fenotipo celular en la enfermedad de envejecimiento prematuro HGPS"},"content":{"rendered":"<p>[et_pb_section fb_built=\u201d1\u2033 _builder_version=\u201d3.22\u2033][et_pb_row _builder_version=\u201d3.25\u2033 background_size=\u201dinicial\u201d background_position=\u201darriba_izquierda\u201d background_repeat=\u201drepetir\u201d][et_pb_column type=\u201d4_4\u2033 _builder_version=\u201d3.25\u2033 custom_padding=\u201d|||\u201d custom_padding__hover=\u201d|||\u201d][et_pb_text _builder_version=\u201d4.6.5\u2033 background_size=\u201dinicial\u201d background_position=\u201darriba_izquierda\u201d background_repeat=\u201drepetir\u201d hover_enabled=\u201d0\u2033 sticky_enabled=\u201d0\u2033]<\/p>\n<p>Las c\u00e9lulas de pacientes con s\u00edndrome de progeria de Hutchinson-Gilford (HGPS) pueden recuperar su salud, seg\u00fan los hallazgos de cient\u00edficos del Instituto Nacional del C\u00e1ncer, parte de los Institutos Nacionales de Salud.<\/p>\n<p><em>Publicado en l\u00ednea el 6 de marzo de 2005 en Nature Medicine <a href=\"https:\/\/www.nature.com\/\" target=\"_blank\" rel=\"noopener noreferrer\">www.naturaleza.com<\/a><\/em><\/p>\n<p>Seg\u00fan los hallazgos de los cient\u00edficos del Instituto Nacional del C\u00e1ncer, parte de los Institutos Nacionales de Salud, las c\u00e9lulas de pacientes con s\u00edndrome de progeria de Hutchinson-Gilford (HGPS) pueden recuperar su salud. Mediante segmentos cortos de ADN especialmente modificados, los investigadores del NCI Paola Scaffidi, PhD, y Tom Misteli, PhD (ambos participantes del taller PRF de 2003), revirtieron los defectos observados en las c\u00e9lulas de HGPS eliminando la prote\u00edna lamina A que es defectuosa en el HGPS. Al demostrar que los fenotipos celulares del HGPS son reversibles, este estudio acerca a los cient\u00edficos un paso m\u00e1s a la cura de esta devastadora enfermedad infantil.<\/p>\n<p>\u201cNos propusimos preguntar si estos cambios celulares asociados con la progeria son permanentes o pueden revertirse\u201d, dijo Scaffidi. Los investigadores dise\u00f1aron un \u201ccurita molecular\u201d, dijo Misteli (un oligonucle\u00f3tido de ADN qu\u00edmicamente estable, para que la c\u00e9lula no pudiera degradarlo). Una semana despu\u00e9s, la prote\u00edna lamina A mutante hab\u00eda sido eliminada y m\u00e1s del 90 por ciento de las c\u00e9lulas de progeria parec\u00edan normales; y la actividad de varios genes que est\u00e1n mal regulados en pacientes con HGPS tambi\u00e9n se restableci\u00f3 a la normalidad. \u201cEs sorprendente que pudi\u00e9ramos tomar una c\u00e9lula enferma y unos d\u00edas despu\u00e9s estuviera sana y lista para dividirse nuevamente\u201d, dijo Misteli.<\/p>\n<p>Se\u00f1al\u00f3 que estos resultados demuestran una prueba de principio de que los efectos celulares de la progeria pueden revertirse, lo que significa que el m\u00e9todo de su laboratorio podr\u00eda alg\u00fan d\u00eda usarse como estrategia terap\u00e9utica.<\/p>\n<p><strong>Los niveles reducidos de colesterol \u201cbueno\u201d en ni\u00f1os con progeria pueden contribuir a una enfermedad card\u00edaca prematura.<\/strong> La adiponectina, una hormona que regula el metabolismo de la grasa y el az\u00facar, puede ser \u00fatil para encontrar tratamientos.<br \/><em>Revista de Pediatr\u00eda, marzo de 2005<\/em><\/p>\n<p>Un equipo de investigadores dirigido por el director m\u00e9dico de PRF y profesor adjunto de la Facultad de Medicina de la Universidad de Tufts, Leslie Gordon, MD, PhD, descubri\u00f3 que los ni\u00f1os con progeria en sus a\u00f1os intermedios y avanzados tienen niveles reducidos de colesterol HDL (o colesterol &quot;protector&quot;) y adiponectina, una hormona que regula el metabolismo de la grasa y el az\u00facar. Ambos factores act\u00faan para eliminar la grasa de las placas en las arterias, y los niveles m\u00e1s bajos pueden contribuir a acelerar la formaci\u00f3n de placa. &quot;Todos los ni\u00f1os con progeria mueren entre los 6 y los 20 a\u00f1os de edad por insuficiencia card\u00edaca o accidente cerebrovascular&quot;, dijo el Dr. Gordon. &quot;Estudiar la enfermedad card\u00edaca en relaci\u00f3n con los ni\u00f1os con progeria puede ayudarnos a comprender mejor c\u00f3mo afectar\u00e1 la aterosclerosis a la poblaci\u00f3n que envejece y, al mismo tiempo, ayudar a estos preciosos ni\u00f1os&quot;.<\/p>\n<p>\u201cEstos hallazgos son importantes para el posible desarrollo de un tratamiento para la progeria\u201d, afirm\u00f3 el autor principal del estudio.<strong> Alice H. Lichtenstein, DSc, Centro de Investigaci\u00f3n sobre Nutrici\u00f3n Humana y Envejecimiento de la Universidad Tufts. <\/strong>\u201cSi se dispone de medicamentos fiables para aumentar los niveles de colesterol HDL y adiponectina, podr\u00edan resultar beneficiosos para prevenir la progresi\u00f3n de la aterosclerosis en ni\u00f1os con progeria\u201d.<\/p>\n<p>\u201cEstos datos tambi\u00e9n refuerzan la importancia del tejido adiposo como tejido activo que secreta hormonas que pueden influir en la funci\u00f3n metab\u00f3lica de todo el cuerpo, un concepto importante no solo para la progeria sino tambi\u00e9n para enfermedades m\u00e1s comunes como la obesidad y la diabetes\u201d, comenta el autor. <strong>Dra. Mary Elizabeth Patti, Joslin Diabetes Center y Departamento de Medicina, Facultad de Medicina de Harvard, Boston, MA<\/strong><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"<p>[et_pb_section fb_built=\u201d1\u2033 _builder_version=\u201d3.22\u2033][et_pb_row _builder_version=\u201d3.25\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201drepeat\u201d][et_pb_column type=\u201d4_4\u2033 _builder_version=\u201d3.25\u2033 custom_padding=\u201d|||\u201d custom_padding__hover=\u201d|||\u201d][et_pb_text _builder_version=\u201d4.6.5\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201drepeat\u201d hover_enabled=\u201d0\u2033 sticky_enabled=\u201d0\u2033] Las c\u00e9lulas de pacientes con s\u00edndrome de progeria de Hutchinson-Gilford (HGPS) pueden recuperar su salud, seg\u00fan hallazgos de cient\u00edficos del Instituto Nacional del C\u00e1ncer, perteneciente a los Institutos Nacionales de la Salud. Publicado en l\u00ednea el 6 de marzo de 2005 en Nature [\u2026]<\/p>","protected":false},"author":1,"featured_media":2043,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"<p>[vc_custom_heading text=\"Reversal of the cellular phenotype in the premature aging disease HGPS\" font_container=\"tag:h1|text_align:left\" use_theme_fonts=\"yes\"]<\/p><div id=\"secondary-header-content\"><div id=\"secondary-header-content\"><p>Cells from patients with Hutchinson-Gilford Progeria Syndrome (HGPS) can be made healthy again, according to findings by scientists at the National Cancer Institute, part of the National Institutes of Health.<\/p><\/div><\/div><p><em>Published online on March 6, 2005 in Nature Medicine <a href=\"https:\/\/www.nature.com\/\">(www.nature.com)<\/a><\/em><\/p><p>Cells from patients with Hutchinson-Gilford Progeria Syndrome (HGPS) can be made healthy again, according to findings by scientists at the National Cancer Institute, part of the National Institutes of Health. Using specially modified short segments of DNA, NCI researchers Paola Scaffidi, PhD, and Tom Misteli, PhD (both 2003 PRF Workshop participants), reversed the defects seen in HGPS cells by eliminating the lamin A protein that is faulty in HGPS. By demonstrating that HGPS cellular phenotypes are reversible, this study brings scientists one step closer to curing this devastating childhood disease.<\/p><p>\"We set out to ask whether these cellular changes associated with Progeria are permanent or can be reversed,\" said Scaffidi. The researchers designed a \"molecular Band-Aid\u00ae,\" said Misteli (a chemically stable DNA oligonucleotide -so the cell wouldn't be able to degrade it.) One week later, the mutant lamin A protein had been eliminated and more than 90 percent of progeria cells looked normal; and the activity of several genes that are misregulated in HGPS patients were also restored to normal. \"It's amazing that we could take a sick cell and a few days later it's healthy and ready to divide again,\" said Misteli.<\/p><p>He noted that these results demonstrate a proof-of-principle that the cellular effects of Progeria can be reversed, meaning his laboratory's method might someday be used as a therapeutic strategy.<\/p><p><strong>Decreased levels of \"good\" cholesterol in children with Progeria may contribute to premature heart disease.<\/strong> Adiponectin - a hormone that regulates the metabolism of fat and sugar - may be helpful in finding treatments.<br \/><em>The Journal of Pediatrics, March 2005<\/em><\/p><p>A team of researchers led by PRF's Medical Director and Tufts University School of Medicine Assistant Professor Leslie Gordon, MD, PhD, discovered that children with Progeria in their mid- and later years have decreased levels of HDL cholesterol - or \"protective\" cholesterol\" - and adiponectin, a hormone that regulates the metabolism of fat and sugar. Both factors work to remove fat from plaques in arteries, and the lower levels may contribute to accelerated plaque formation. \"All children with Progeria die between the ages of 6 and 20 years from heart failure or stroke,\" said Dr. Gordon. \"Studying heart disease as it relates to children with Progeria can help us better understand how atherosclerosis will affect the aging population while also helping these precious children.\"<\/p><p>\"These findings are important for the potential development of a treatment for Progeria,\" said senior study author<strong> Alice H. Lichtenstein, DSc, Human Nutrition Research Center on Aging at Tufts University. <\/strong>\"If reliable drugs used to increase HDL cholesterol and adiponectin levels become available, they may prove beneficial in preventing the progression of atherosclerosis in children with Progeria.\"<\/p><p>\"These data also reinforce the importance of adipose tissue as an active tissue which secretes hormones which can influence metabolic function of the entire body - a concept important not only for Progeria but also for more common diseases such as obesity and diabetes\", comments author <strong>Mary Elizabeth Patti, MD, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, MA<\/strong><\/p>","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-2135","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Reversal of the cellular phenotype in the premature aging disease HGPS - The Progeria Research Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.progeriaresearch.org\/es\/2005\/05\/16\/reversal-of-the-cellular-phenotype-in-the-premature-aging-disease-hgps\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Reversal of the cellular phenotype in the premature aging disease HGPS - The Progeria Research Foundation\" \/>\n<meta property=\"og:description\" content=\"[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;3.22&#8243;][et_pb_row _builder_version=&#8221;3.25&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.6.5&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;] Cells from patients with Hutchinson-Gilford Progeria Syndrome (HGPS) can be made healthy again, according to findings by scientists at the National Cancer Institute, part of the National Institutes of Health. Published online on March 6, 2005 in Nature [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.progeriaresearch.org\/es\/2005\/05\/16\/reversal-of-the-cellular-phenotype-in-the-premature-aging-disease-hgps\/\" \/>\n<meta property=\"og:site_name\" content=\"The Progeria Research Foundation\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ProgeriaResearch\/\" \/>\n<meta property=\"article:published_time\" content=\"2005-05-16T20:48:59+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-12-09T15:24:44+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2011\/05\/1PRFlogo2010_300dpi.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"165\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"gravoc\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@Progeria\" \/>\n<meta name=\"twitter:site\" content=\"@Progeria\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"gravoc\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.progeriaresearch.org\/ru\/2005\/05\/16\/reversal-of-the-cellular-phenotype-in-the-premature-aging-disease-hgps\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/ru\/2005\/05\/16\/reversal-of-the-cellular-phenotype-in-the-premature-aging-disease-hgps\/\"},\"author\":{\"name\":\"gravoc\",\"@id\":\"https:\/\/www.progeriaresearch.org\/ta\/#\/schema\/person\/a3c935a81e92242c6a77ae0018542928\"},\"headline\":\"Reversal of the cellular phenotype in the premature aging disease HGPS\",\"datePublished\":\"2005-05-16T20:48:59+00:00\",\"dateModified\":\"2020-12-09T15:24:44+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/ru\/2005\/05\/16\/reversal-of-the-cellular-phenotype-in-the-premature-aging-disease-hgps\/\"},\"wordCount\":620,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/ta\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/ru\/2005\/05\/16\/reversal-of-the-cellular-phenotype-in-the-premature-aging-disease-hgps\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2011\/05\/1PRFlogo2010_300dpi.jpg\",\"articleSection\":[\"News\"],\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.progeriaresearch.org\/ru\/2005\/05\/16\/reversal-of-the-cellular-phenotype-in-the-premature-aging-disease-hgps\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.progeriaresearch.org\/ru\/2005\/05\/16\/reversal-of-the-cellular-phenotype-in-the-premature-aging-disease-hgps\/\",\"url\":\"https:\/\/www.progeriaresearch.org\/ru\/2005\/05\/16\/reversal-of-the-cellular-phenotype-in-the-premature-aging-disease-hgps\/\",\"name\":\"Reversal of the cellular phenotype in the premature aging disease HGPS - 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The Progeria Research Foundation","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.progeriaresearch.org\/es\/2005\/05\/16\/reversal-of-the-cellular-phenotype-in-the-premature-aging-disease-hgps\/","og_locale":"es_ES","og_type":"article","og_title":"Reversal of the cellular phenotype in the premature aging disease HGPS - The Progeria Research Foundation","og_description":"[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;3.22&#8243;][et_pb_row _builder_version=&#8221;3.25&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.6.5&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;] Cells from patients with Hutchinson-Gilford Progeria Syndrome (HGPS) can be made healthy again, according to findings by scientists at the National Cancer Institute, part of the National Institutes of Health. 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