[et_pb_section fb_built=\u201d1\u2033 fullwidth=\u201don\u201d disabled_on=\u201doff|off|off\u201d _builder_version=\u201d4.16\u2033 border_width_bottom=\u201d55px\u201d border_color_bottom=\u201d#29327a\u201d global_colors_info=\u201d{}\u201d][et_pb_fullwidth_header _builder_version=\u201d4.16\u2033 title_font_size=\u201d55\u2033 background_color=\u201d#29327a\u201d background_image=\u201dhttps:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/About-Header.jpg\u201d background_position=\u201dcenter_left\u201d custom_padding=\u201d9vw||9vw||true\u201d custom_padding_tablet=\u201d\u201d custom_padding_phone=\u201d|56px||\u201d custom_padding_last_edited=\u201dsur|bureau\u201d title_font_size_tablet=\u201d45px\u201d title_font_size_phone=\u201d40px\u201d title_font_size_last_edited=\u201dsur|t\u00e9l\u00e9phone\u201d z_index_tablet=\u201d500\u2033 custom_css_main_element=\u201dbackground-position: center 18% !important;\u201d global_colors_info=\u201d{}\u201d]<\/p>\n
[\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=\u201d1\u2033 use_custom_gutter=\u201don\u201d gutter_width=\u201d1\u2033 specialty=\u201don\u201d padding_left_1=\u201d35px\u201d padding_left_2=\u201d35px\u201d padding_2_tablet=\u201d|||0px\u201d padding_2_phone=\u201d|||0px\u201d padding_2_last_edited=\u201don|desktop\u201d module_class_1=\u201dsidebar-secondary-nav\u201d module_class=\u201dempreinte-de-la-main-bg\u201d _builder_version=\u201d4.16\u2033 background_image=\u201dhttps:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/empreinte-de-la-main-bleue-uniquement.png\u201d parallax=\u201don\u201d parallax_method=\u201doff\u201d inner_width=\u201d100%\u201d inner_max_width=\u201d100%\u201d custom_padding=\u201d0|0px|54px|0px|false|false\u201d z_index_tablet=\u201d500\u2033 border_width_top=\u201d10px\u201d border_color_top=\u201d#8fd2ed\u201d use_custom_width=\u201don\u201d width_unit=\u201doff\u201d custom_width_percent=\u201d100%\u201d global_colors_info=\u201d{}\u201d][et_pb_column type=\u201d1_4\u2033 _builder_version=\u201d4.16\u2033 custom_padding=\u201d|||\u201d global_colors_info=\u201d{}\u201d custom_padding__hover=\u201d|||\u201d][et_pb_sidebar area=\u201det_pb_widget_area_18\u2033 disabled_on=\u201don|on|off\u201d module_class=\u201dsubpage-sidebars\u201d _builder_version=\u201d4.16\u2033 animation_style=\u201dfade\u201d z_index_tablet=\u201d500\u2033 border_width_right=\u201d5px\u201d global_colors_info=\u201d{}\u201d]
\n[\/et_pb_sidebar][\/et_pb_column][et_pb_column type=\u201d3_4\u2033 specialty_columns=\u201d3\u2033 _builder_version=\u201d4.16\u2033 custom_padding=\u201d|||\u201d global_colors_info=\u201d{}\u201d custom_padding__hover=\u201d|||\u201d][et_pb_row_inner custom_padding_last_edited=\u201don|phone\u201d _builder_version=\u201d4.16\u2033 custom_padding=\u201d39.4375px|35px|35px||false|false\u201d custom_padding_tablet=\u201d|35px||35px||true\u201d custom_padding_phone=\u201d\u201d animation_direction=\u201dhaut\u201d global_colors_info=\u201d{}\u201d][et_pb_column_inner saved_specialty_column_type=\u201d3_4\u2033 _builder_version=\u201d4.16\u2033 custom_padding=\u201d|||\u201d global_colors_info=\u201d{}\u201d custom_padding__hover=\u201d|||\u201d][et_pb_text _builder_version=\u201d4.16\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201dr\u00e9p\u00e9ter\u201d global_colors_info=\u201d{}\u201d]<\/p>\n
Les enfants atteints de prog\u00e9ria sont g\u00e9n\u00e9tiquement pr\u00e9dispos\u00e9s \u00e0 une maladie cardiaque pr\u00e9matur\u00e9e et progressive. La mort survient presque exclusivement \u00e0 cause d'une maladie cardiaque g\u00e9n\u00e9ralis\u00e9e, principale cause de d\u00e9c\u00e8s aux \u00c9tats-Unis et dans le monde entier. Comme pour toute personne souffrant d'une maladie cardiaque, les \u00e9v\u00e9nements courants chez les enfants atteints de prog\u00e9ria sont les accidents vasculaires c\u00e9r\u00e9braux, l'hypertension art\u00e9rielle, l'angine de poitrine, l'hypertrophie cardiaque et l'insuffisance cardiaque, toutes des affections associ\u00e9es au vieillissement.<\/p>\n
[\/et_pb_text][et_pb_testimonial author=\u201dDr. Samer Najjar\u201d job_title=\u201dChef de l\u2019Unit\u00e9 d\u2019\u00e9tudes cardiovasculaires humaines\u201d company_name=\u201dL\u2019Institut national du vieillissement\u201d quote_icon_color=\u201d#00b2e2\u2033 portrait_width=\u201d140px\u201d portrait_height=\u201d140px\u201d admin_label=\u201dCitation du Dr Samer Najjar\u201d _builder_version=\u201d4.16\u2033 background_color=\u201d#f7f7f7\u2033 custom_margin=\u201d50px||\u201d custom_margin_tablet=\u201d\u201d custom_margin_phone=\u201d\u201d custom_margin_last_edited=\u201don|desktop\u201d z_index_tablet=\u201d500\u2033 custom_css_testimonial_author=\u201dcolor: #00b2e2;||font-size: 19px !important;||font-weight: 700;\u201d custom_css_testimonial_meta=\u201dfont-style: italic;||font-weight: 700;\u201d box_shadow_style_image=\u201dpreset3\u2033 locked=\u201doff\u201d global_colors_info=\u201d{}\u201d]<\/p>\n
\u00a0\u00ab Ces enfants d\u00e9veloppent des maladies cardiaques \u00e0 un rythme incroyablement rapide, g\u00e9n\u00e9ralement vers l'\u00e2ge de 12, 13 ou 14 ans. Dans la soci\u00e9t\u00e9 en g\u00e9n\u00e9ral, la pr\u00e9valence des maladies cardiovasculaires commence \u00e0 appara\u00eetre entre 60 et 70 ans. Il est \u00e9vident que le processus s'acc\u00e9l\u00e8re. \u00bb<\/p>\n
[\/et_pb_testimonial][et_pb_text _builder_version=\u201d4.16\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201drepeat\u201d global_colors_info=\u201d{}\u201d]<\/p>\n
Il y a donc clairement un besoin \u00e9norme de recherche sur la prog\u00e9ria. Trouver un rem\u00e8de contre la prog\u00e9ria aidera non seulement ces enfants, mais pourrait \u00e9galement fournir des cl\u00e9s pour traiter des millions d'adultes souffrant de maladies cardiaques et d'accidents vasculaires c\u00e9r\u00e9braux associ\u00e9s au processus naturel de vieillissement.<\/em>.<\/p>\n Cliquez ici pour en savoir plus sur la recherche qui sugg\u00e8re un lien entre la prog\u00e9ria et le vieillissement normal.\u00a0<\/a><\/p>\n [\/et_pb_text][et_pb_text _builder_version=\u201d4.16\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201dr\u00e9p\u00e9ter\u201d global_colors_info=\u201d{}\u201d]<\/p>\n <\/p>\n Parce que le processus de vieillissement est acc\u00e9l\u00e9r\u00e9 chez les enfants atteints de prog\u00e9ria, ils offrent aux chercheurs une occasion rare d\u2019observer en quelques ann\u00e9es seulement ce qui n\u00e9cessiterait autrement des d\u00e9cennies d\u2019\u00e9tudes longitudinales.<\/p>\n [\/et_pb_text][et_pb_testimonial author=\u201dDr. Huber Warner\u201d job_title=\u201dDirecteur associ\u00e9\u201d company_name=\u201dL\u2019Institut national sur le vieillissement\u201d quote_icon_color=\u201d#00b2e2\u2033 portrait_width=\u201d140px\u201d portrait_height=\u201d140px\u201d admin_label=\u201dCitation du Dr Huber Warner\u201d _builder_version=\u201d4.16\u2033 background_color=\u201d#f7f7f7\u2033 custom_margin=\u201d50px||\u201d custom_margin_tablet=\u201d\u201d custom_margin_phone=\u201d\u201d custom_margin_last_edited=\u201don|desktop\u201d z_index_tablet=\u201d500\u2033 custom_css_testimonial_author=\u201dcolor: #00b2e2;||font-size: 19px !important;||font-weight: 700;\u201d custom_css_testimonial_meta=\u201dfont-style: italic;||font-weight: 700;\u201d box_shadow_style_image=\u201dpreset3\u2033 locked=\u201doff\u201d global_colors_info=\u201d{}\u201d]<\/p>\n \u00ab Une meilleure compr\u00e9hension des causes de ce syndrome (Progeria) pourrait permettre de mieux comprendre les m\u00e9canismes du d\u00e9veloppement et du vieillissement. \u00bb\u00a0<\/p>\n [\/et_pb_testimonial][et_pb_testimonial author=\u201dDr Vilhelm Bohr\u201d job_title=\u201dPr\u00e9sident de la g\u00e9rontologie mol\u00e9culaire\u201d company_name=\u201dL\u2019Institut national sur le vieillissement\u201d quote_icon_color=\u201d#00b2e2\u2033 portrait_width=\u201d140px\u201d portrait_height=\u201d140px\u201d admin_label=\u201dCitation du Dr Vilhelm Bohr\u201d _builder_version=\u201d4.16\u2033 background_color=\u201d#f7f7f7\u2033 custom_margin=\u201d50px||\u201d custom_margin_tablet=\u201d\u201d custom_margin_phone=\u201d\u201d custom_margin_last_edited=\u201don|desktop\u201d z_index_tablet=\u201d500\u2033 custom_css_testimonial_author=\u201dcolor: #00b2e2;||font-size: 19px !important;||font-weight: 700;\u201d custom_css_testimonial_meta=\u201dfont-style: italic;||font-weight: 700;\u201d box_shadow_style_image=\u201dpreset3\u2033 locked=\u201doff\u201d global_colors_info=\u201d{}\u201d]<\/p>\n \u00ab C\u2019est incroyable \u00e0 quel point la prog\u00e9ria ressemble au processus normal de vieillissement. Je pense que ces prot\u00e9ines li\u00e9es \u00e0 la prog\u00e9ria jouent un r\u00f4le tr\u00e8s important dans le processus de vieillissement, et je pense que nous avons d\u00e9j\u00e0 vu des d\u00e9couvertes assez importantes concernant le r\u00f4le de ces prot\u00e9ines. \u00bb<\/p>\n [\/et_pb_testimonial][et_pb_text _builder_version=\u201d4.16\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201drepeat\u201d global_colors_info=\u201d{}\u201d]<\/p>\n <\/p>\n Les enfants atteints de prog\u00e9ria d\u00e9veloppent et meurent \u00e9galement d\u2019ath\u00e9roscl\u00e9rose et d\u2019art\u00e9rioscl\u00e9rose (commun\u00e9ment appel\u00e9e maladie cardiaque). L\u2019ath\u00e9roscl\u00e9rose n\u2019est qu\u2019un des nombreux types d\u2019art\u00e9rioscl\u00e9rose, caract\u00e9ris\u00e9e par un \u00e9paississement et un durcissement des art\u00e8res, mais les deux termes sont souvent utilis\u00e9s pour signifier la m\u00eame chose. Un certain durcissement des art\u00e8res se produit souvent avec l\u2019\u00e2ge.<\/p>\n L'ath\u00e9roscl\u00e9rose se caract\u00e9rise par des d\u00e9p\u00f4ts de substances grasses dans la paroi interne d'une art\u00e8re. Cette accumulation est appel\u00e9e plaque. Les plaques peuvent devenir suffisamment grandes pour r\u00e9duire consid\u00e9rablement le flux sanguin dans une art\u00e8re, ou devenir fragiles et se rompre pour former des caillots qui peuvent bloquer le flux sanguin. Si le blocage se produit dans une art\u00e8re qui alimente le c\u0153ur, il provoque une crise cardiaque<\/em>. Si le blocage se produit dans une art\u00e8re qui alimente le cerveau, il provoque une accident vasculaire c\u00e9r\u00e9bral<\/em>L'ath\u00e9roscl\u00e9rose n'est pas seulement la cause de d\u00e9c\u00e8s chez les enfants atteints de prog\u00e9ria, mais aussi la principale cause de d\u00e9c\u00e8s aux \u00c9tats-Unis et dans de nombreuses autres r\u00e9gions du monde chez les personnes vieillissantes normales<\/em>Nous esp\u00e9rons que la d\u00e9couverte du g\u00e8ne Progeria aura un effet b\u00e9n\u00e9fique non seulement pour les patients atteints de Progeria, mais aussi pour les millions de personnes touch\u00e9es par des maladies li\u00e9es au vieillissement, notamment les crises cardiaques et les accidents vasculaires c\u00e9r\u00e9braux caus\u00e9s par l\u2019ath\u00e9roscl\u00e9rose et l\u2019art\u00e9rioscl\u00e9rose.<\/p>\n [\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][\/et_pb_section][et_pb_section fb_built=\u201d1\u2033 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_builder_version=\u201d4.16\u2033 border_width_bottom=\u201d55px\u201d border_color_bottom=\u201d#29327a\u201d global_colors_info=\u201d{}\u201d][et_pb_fullwidth_header _builder_version=\u201d4.16\u2033 title_font_size=\u201d55\u2033 background_color=\u201d#29327a\u201d background_image=\u201dhttps:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/About-Header.jpg\u201d background_position=\u201dcenter_left\u201d custom_padding=\u201d9vw||9vw||true\u201d custom_padding_tablet=\u201d\u201d custom_padding_phone=\u201d|56px||\u201d custom_padding_last_edited=\u201dsur|bureau\u201d title_font_size_tablet=\u201d45px\u201d title_font_size_phone=\u201d40px\u201d title_font_size_last_edited=\u201dsur|t\u00e9l\u00e9phone\u201d z_index_tablet=\u201d500\u2033 custom_css_main_element=\u201dbackground-position: center 18% !important;\u201d global_colors_info=\u201d{}\u201d] Le lien avec d\u2019autres maladies [\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=\u201d1\u2033 use_custom_gutter=\u201don\u201d gutter_width=\u201d1\u2033 specialty=\u201don\u201d padding_left_1=\u201d35px\u201d padding_left_2=\u201d35px\u201d padding_2_tablet=\u201d|||0px\u201d padding_2_phone=\u201d|||0px\u201d padding_2_last_edited=\u201don|desktop\u201d module_class_1=\u201dsidebar-secondary-nav\u201d module_class=\u201dhandprint-bg\u201d _builder_version=\u201d4.16\u2033 background_image=\u201dhttps:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/blue-handprint-only.png\u201d parallax=\u201don\u201d parallax_method=\u201doff\u201d inner_width=\u201d100%\u201d inner_max_width=\u201d100%\u201d custom_padding=\u201d0|0px|54px|0px|false|false\u201d z_index_tablet=\u201d500\u2033 border_width_top=\u201d10px\u201d border_color_top=\u201d#8fd2ed\u201d use_custom_width=\u201don\u201d width_unit=\u201doff\u201d [\u2026]<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"\t\t\t\t[vc_row][vc_column][vc_custom_heading text=\"Connection to Other Diseases\" font_container=\"tag:h1|text_align:center\" use_theme_fonts=\"yes\"][vc_column_text]\r\nAth\u00e9roscl\u00e9rose<\/h1>\n
S'inscrire<\/h2>\n
pour notre<\/h2>\n
Bulletin!<\/h2>\n
Ensemble, nous<\/h2>\n
VOLONT\u00c9<\/em><\/h2>\n
trouve le rem\u00e8de !<\/h2>\n
Aging<\/h1>\r\nChildren with Progeria are genetically predisposed to premature, progressive heart disease. Death occurs almost exclusively due to widespread heart disease, the leading cause of death in the US, and #2 worldwide. As with any person suffering from heart disease, the common events for Progeria children are strokes, high blood pressure, angina, enlarged heart, and heart failure, all conditions associated with aging.[\/vc_column_text][vc_column_text]\"These children get heart disease at an incredibly accelerated pace, usually by the time they are 12, 13 or 14. In the general community, the prevalence of cardiovascular disease starts appearing in the 60s and 70s. Obviously, there's some process that's accelerated.\"\r\n\r\n\u2014 Dr. Samer Najjar, head of the Human Cardiovascular Studies Unit at the National Institute on Aging[\/vc_column_text][vc_column_text]Thus there is clearly a tremendous need for research in Progeria. Because finding a cure for Progeria will not only help these children, but may provide keys for treating millions of adults with heart disease and stroke associated with the natural aging process<\/em>.\r\n\r\nBecause the aging process is accelerated in children with Progeria, they offer researchers a rare opportunity to observe in just a few years what would otherwise require decades of longitudinal studies.\r\n\r\n\"A better understanding of the causes of this syndrome (Progeria) could lead to better insights into the mechanisms of both development and aging.\" - National Institute of Aging Associate Director Dr. Huber Warner\r\n\r\nClick here to find out more about the research that suggests a link between Progeria and normal aging<\/a>[\/vc_column_text][vc_column_text]\"It's amazing how much Progeria resembles the normal aging process. I think these proteins linked to Progeria play a very profound role in the aging process, and I think we've already seen some pretty big findings in terms of what these proteins do.\r\n\r\n\u2014 Dr. Vilhelm Bohr, chairman of molecular gerontology at the National Institute on Aging[\/vc_column_text][vc_column_text]\r\n
Atherosclerosis<\/h1>\r\nChildren with Progeria also develop and die of atherosclerosis and arteriosclerosis (commonly referred to as heart disease). Atherosclerosis is just one of several types of \"arterio\"-sclerosis, which is characterized by thickening and hardening of the arteries, but the two terms are often used to mean the same thing. Some hardening of the arteries often occurs when people grow older.\r\n\r\nAtherosclerosis involves deposits of fatty substances in the inner lining of an artery. This buildup is called plaque. Plaques can grow large enough to significantly reduce the flow of blood through an artery, or plaques become fragile and rupture to form clots that can block blood flow. If the blockage occurs to an artery that feeds into the heart, it causes a heart attack<\/em>. If the blockage occurs to an artery that feeds into the brain, it causes a stroke<\/em>. Atherosclerosis is not only the cause of death among children with Progeria, but also the leading cause of death in the United States and many other parts of the world in normal aging individuals<\/em>. It is our hope that the discovery of the Progeria gene will have a beneficial effect not only for Progeria patients, but also for the millions of people affected by aging-related conditions, including heart attacks and stroke caused by atherosclerosis and arteriosclerosis.[\/vc_column_text][\/vc_column][\/vc_row]\t\t","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-770","page","type-page","status-publish","hentry"],"yoast_head":"\n