{"id":20799,"date":"2025-08-08T10:11:20","date_gmt":"2025-08-08T14:11:20","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?p=20799"},"modified":"2026-01-13T13:38:13","modified_gmt":"2026-01-13T18:38:13","slug":"gene-editing","status":"publish","type":"post","link":"https:\/\/www.progeriaresearch.org\/fr\/2025\/08\/08\/gene-editing\/","title":{"rendered":"Le New Yorker pr\u00e9sente l'\u00e9dition g\u00e9n\u00e9tique de la prog\u00e9ria : le PRF est sur la voie de la GU\u00c9RISON DE LA PROG\u00c9RIA !"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”-74px|auto||auto|false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text admin_label=”Path & Alptug images” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

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Comme d\u00e9crit dans l'article de premi\u00e8re page du New Yorker du 11 ao\u00fbt 2025**, intitul\u00e9 Comment une maladie ultra-rare acc\u00e9l\u00e8re le vieillissement,\u00a0<\/em>\u00a0La Fondation de recherche sur la prog\u00e9ria est ravie d'annoncer le projet pionnier sur la prog\u00e9ria\u00a0Programme d'\u00e9dition g\u00e9n\u00e9tique.<\/strong>\u00a0<\/p>\n

**Cliquez ici<\/strong><\/a> pour lire l'article complet.<\/p>\n

[\/et_pb_text][et_pb_testimonial quote_icon_color=”#FFFFFF” quote_icon_background_color=”#8FD2ED” admin_label=”KayleeQuote” _builder_version=”4.27.4″ _module_preset=”default” min_height=”83px” custom_margin=”0px||||false|false” custom_padding=”1px||12px||false|false” hover_enabled=”0″ border_radii=”on|35px|35px|35px|35px” border_width_all=”2px” border_color_all=”#00B2E2″ global_colors_info=”{}” theme_builder_area=”post_content” sticky_enabled=”0″]<\/p>\n

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\u201c Je suis impliqu\u00e9e dans le PRF depuis toujours \u201d, explique Kaylee, 22 ans, originaire de l'Ohio et dont le portrait est largement diffus\u00e9 dans l'article du New Yorker. \u201c Je suis vraiment enthousiaste \u00e0 propos de la th\u00e9rapie g\u00e9nique sur laquelle ils travaillent ! \u201d<\/strong><\/p>\n

[\/et_pb_testimonial][et_pb_text admin_label=”Kaylee image and Base editing text” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

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Th\u00e9rapie d'\u00e9dition de base<\/strong>\u00a0utilise la technologie CRISPR pour cibler et corriger une base d\u2019ADN sp\u00e9cifique (ou \u00ab lettre \u00bb) dans le code g\u00e9n\u00e9tique. \u00c9tant donn\u00e9 que la prog\u00e9ria est caus\u00e9e par une modification d\u2019une seule lettre de l\u2019ADN, elle est parfaitement adapt\u00e9e \u00e0 ce type de th\u00e9rapie g\u00e9nique.<\/strong><\/p>\n

[\/et_pb_text][et_pb_text admin_label=”Progeria Gene Dream Team” _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”||0px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

L'\u00e9quipe g\u00e9n\u00e9tique de la prog\u00e9ria <\/strong><\/span><\/h4>\n

La PRF collabore avec une \u00e9quipe extraordinaire de scientifiques et d'innovateurs de renomm\u00e9e mondiale. Gr\u00e2ce \u00e0 leur travail acharn\u00e9 et \u00e0 leur d\u00e9vouement, cette th\u00e9rapie transformatrice devient r\u00e9alit\u00e9\u00a0:<\/p>\n

\"\"De haut \u00e0 gauche \u00e0 bas \u00e0 droite :
Dr Francis Collins, Ph. D.<\/strong>\u00a0\u2013 Partenaire de recherche de longue date sur la prog\u00e9ria et ancien directeur des National Institutes of Health (NIH)
Dr Michael Erdos<\/strong>\u00a0\u2013 Chercheur associ\u00e9, Section de g\u00e9n\u00e9tique mol\u00e9culaire, Institut national de recherche sur le g\u00e9nome humain (NHGRI)
Dr Leslie Gordon, Ph. D.<\/strong>\u00a0\u2013 Cofondateur et directeur m\u00e9dical du PRF, et le plus grand expert mondial de la prog\u00e9ria
David Liu, Ph. D.<\/strong>\u00a0\u2013 Scientifique du Broad Institute du MIT et de l'Universit\u00e9 Harvard, fondateur de\u00a0\u00c9dition de base<\/strong>\u00a0<\/strong>Technologie de th\u00e9rapie g\u00e9nique
*Sammy Basso<\/strong><\/a>, MS, co-fondateur de l'Associazione Italiana Progeria Sammy Basso et ambassadeur du PRF, a fait partie int\u00e9grante de cette \u00e9quipe jusqu'\u00e0 son d\u00e9c\u00e8s en octobre 2024.<\/p>\n

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Du mod\u00e8le murin aux essais cliniques<\/strong><\/span><\/h4>\n

L'\u00e9quipe g\u00e9n\u00e9tique de la Prog\u00e9ria et les membres de leur laboratoire ont d\u00e9montr\u00e9 pour la premi\u00e8re fois que l'\u00e9dition g\u00e9n\u00e9tique pouvait augmenter consid\u00e9rablement la dur\u00e9e de vie<\/strong> du mod\u00e8le de souris Progeria \u2014 par une \u00e9tonnante\u00a0140%<\/strong>\u00a0\u2014 une d\u00e9couverte qui a \u00e9t\u00e9 publi\u00e9e dans l\u2019une des plus grandes revues scientifiques du monde,\u00a0Nature<\/em><\/strong><\/a>S\u2019appuyant sur cette r\u00e9alisation remarquable, l\u2019\u00e9quipe a affin\u00e9 le m\u00e9dicament et se concentre d\u00e9sormais sur les \u00e9tapes n\u00e9cessaires pour d\u00e9marrer un essai clinique : la fabrication du m\u00e9dicament, l\u2019engagement avec la FDA am\u00e9ricaine et le d\u00e9veloppement de protocoles d\u2019essais cliniques.<\/p>\n

Le voyage \u00e0 venir sera en plusieurs \u00e9tapes, techniquement compliqu\u00e9 et co\u00fbteux. PRF est d\u00e9termin\u00e9 \u00e0 relever tous les d\u00e9fis pour apporter la th\u00e9rapie g\u00e9nique aux enfants et aux jeunes adultes atteints de Progeria.<\/strong><\/p>\n

[\/et_pb_text][et_pb_text admin_label=”Community-Driven Mission” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Une mission ax\u00e9e sur la communaut\u00e9<\/strong><\/span><\/h4>\n

La communaut\u00e9 Progeria nous a accompagn\u00e9s \u00e0 chaque \u00e9tape du processus.<\/strong> L'\u00e9quipe de direction du PRF organise r\u00e9guli\u00e8rement des r\u00e9unions en ligne avec des familles atteintes de Progeria dans le monde entier. Elles sont donc nos partenaires dans ce voyage vers la gu\u00e9rison.<\/p>\n

De plus, les implications de ce travail pourraient s\u2019\u00e9tendre bien au-del\u00e0 de la prog\u00e9ria. En plus de gu\u00e9rir la prog\u00e9ria, nous ouvrons la voie \u00e0 d\u2019autres maladies rares. <\/strong>Cela pourrait donc constituer une avanc\u00e9e majeure non seulement pour la prog\u00e9ria, mais aussi pour d\u2019autres maladies qui ont longtemps \u00e9t\u00e9 n\u00e9glig\u00e9es.<\/i><\/p>\n

[\/et_pb_text][et_pb_testimonial quote_icon_color=”#FFFFFF” quote_icon_background_color=”#8FD2ED” admin_label=”Liu Quote” _builder_version=”4.27.4″ _module_preset=”default” min_height=”83px” custom_margin=”0px||||false|false” custom_padding=”1px||12px||false|false” border_radii=”on|35px|35px|35px|35px” border_width_all=”2px” border_color_all=”#00B2E2″ global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

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\u00ab L\u2019espoir de notre \u00e9quipe est d\u2019utiliser l\u2019\u00e9dition de base pour corriger la cause profonde de la prog\u00e9ria, ouvrant ainsi la voie \u00e0 un rem\u00e8de potentiel pour les enfants atteints de prog\u00e9ria, ainsi qu\u2019\u00e0 faire progresser les traitements pour des millions d\u2019autres enfants atteints de maladies g\u00e9n\u00e9tiques mortelles. \u00bb<\/strong><\/p>\n

[\/et_pb_testimonial][et_pb_text admin_label=”Liu & Sammy B” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”Your Support is Vital” _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”8px|||||” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Votre soutien est vital <\/strong><\/span><\/h4>\n

La th\u00e9rapie g\u00e9nique est le type de m\u00e9dicament le plus prometteur et le plus co\u00fbteux \u00e0 fabriquer. L'engagement ind\u00e9fectible des partisans passionn\u00e9s du PRF comme vous fera de l'\u00e9dition g\u00e9n\u00e9tique de la Progeria une r\u00e9alit\u00e9.<\/strong><\/p>\n

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Ensemble, nous sommes \u00e0 l\u2019aube de quelque chose d\u2019extraordinaire. <\/strong><\/h4>\n

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<\/strong><\/span><\/h4>\n

Ensemble, nous VOLONT\u00c9<\/em> trouve le rem\u00e8de !<\/strong><\/span><\/h4>\n

[\/et_pb_text][et_pb_button button_url=”https:\/\/www.progeriaresearch.org\/2025\/05\/27\/rdd-2025-cimus\/?form=donate” button_text=”Donate to Fund Progeria Gene Therapy!” button_alignment=”center” admin_label=”Donate button” _builder_version=”4.27.4″ _module_preset=”default” button_text_color=”#FFFFFF” button_bg_color=”#00B2E2″ button_border_color=”#00B2E2″ background_layout=”dark” custom_margin=”50px||||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"

Le 11 ao\u00fbt 2025, cette publication de premier plan a publi\u00e9 un article d\u00e9taill\u00e9 d\u00e9taillant l'histoire, les r\u00e9alisations et les efforts actuels de la PRF pour d\u00e9velopper une th\u00e9rapie g\u00e9nique susceptible de nous rapprocher de la gu\u00e9rison de la prog\u00e9ria. Notre extraordinaire parcours touche des millions de personnes \u00e0 travers le monde\u00a0!<\/p>","protected":false},"author":2,"featured_media":20856,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[11,2,1],"tags":[],"class_list":["post-20799","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-homepage-news","category-news","category-uncategorized"],"yoast_head":"\nGene Editing: PRF I The Progeria Research Foundation<\/title>\n<meta name=\"description\" content=\"On August 11, 2025, this top-tier publication featured an in-depth article detailing PRF\u2019s history, accomplishments, and present focus on the Gene Therapy that could bring us closer to curing Progeria. 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\"\"David Liu,\u00a0Laur\u00e9at du prix Breakthrough 2025 en sciences de la vie<\/a> pour le d\u00e9veloppement du montage de base et du montage principal, avec Sammy Basso \u00e0 la conf\u00e9rence Brilliant Minds en Su\u00e8de en 2023. Ils ont re\u00e7u une ovation debout pour leur pr\u00e9sentation sur le montage de base et la prog\u00e9ria.<\/strong>
<\/i><\/p>\n