{"id":2113,"date":"2006-02-16T20:28:04","date_gmt":"2006-02-16T20:28:04","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?p=2113"},"modified":"2020-12-09T11:16:33","modified_gmt":"2020-12-09T16:16:33","slug":"three-studies-released-that-bring-us-closer-than-ever-to-understanding-progeria-and-to-disease-treatment","status":"publish","type":"post","link":"https:\/\/www.progeriaresearch.org\/fr\/2006\/02\/16\/three-studies-released-that-bring-us-closer-than-ever-to-understanding-progeria-and-to-disease-treatment\/","title":{"rendered":"Trois \u00e9tudes publi\u00e9es nous rapprochent plus que jamais de la compr\u00e9hension de la prog\u00e9ria et du traitement de la maladie"},"content":{"rendered":"

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Des chercheurs de l'UCLA, financ\u00e9s par le PRF, ont utilis\u00e9 un mod\u00e8le de souris de type Progeria et ont test\u00e9 un traitement m\u00e9dicamenteux potentiel pour les enfants atteints de Progeria. Leur \u00e9tude publi\u00e9e dans Science le 16 f\u00e9vrier a r\u00e9v\u00e9l\u00e9 que ce m\u00e9dicament FTI am\u00e9liore certains signes de la maladie.<\/p>\n

En septembre, la Progeria Research Foundation a eu le plaisir d\u2019annoncer que des chercheurs financ\u00e9s par la PRF avaient publi\u00e9 des \u00e9tudes soutenant un traitement m\u00e9dicamenteux potentiel pour les enfants atteints de prog\u00e9ria \u2013 les cellules de la prog\u00e9ria se sont normalis\u00e9es (dans une bo\u00eete de P\u00e9tri) lorsqu\u2019on leur a administr\u00e9 ce m\u00e9dicament. La phase suivante de tests a \u00e9t\u00e9 r\u00e9alis\u00e9e sur des mod\u00e8les animaux, et nous sommes ravis d\u2019annoncer qu\u2019une \u00e9tude publi\u00e9e dans Science le 16 f\u00e9vrier a r\u00e9v\u00e9l\u00e9 que ce m\u00e9dicament FTI am\u00e9liore certains signes de la maladie dans un mod\u00e8le de souris de type prog\u00e9ria. La PRF a aid\u00e9 \u00e0 financer les chercheurs de l\u2019UCLA, le Dr Loren Fong et le Dr Stephen Young, pour cette derni\u00e8re \u00e9tape vitale vers des essais de traitement clinique avec les enfants. Cliquez ici pour plus de d\u00e9tails<\/a> sur cette nouvelle passionnante.<\/p>\n

Et les publications scientifiques continuent ! Le PRF a financ\u00e9 une \u00e9tude men\u00e9e par le Dr Karima Djabali, en collaboration avec le Dr Dayle McClintock et le Dr Leslie B. Gordon, directeur m\u00e9dical du PRF, qui vient d'\u00eatre publi\u00e9e dans le num\u00e9ro de cette semaine du PNAS (Actes de l'Acad\u00e9mie nationale des sciences).<\/em> L'\u00e9tude conclut que la prot\u00e9ine d\u00e9fectueuse produite par le g\u00e8ne de la prog\u00e9ria (appel\u00e9e prog\u00e9rine) s'accumule dans les cellules des parois vasculaires des enfants. Cela nous montre, pour la premi\u00e8re fois, qu'il existe un lien direct entre la prog\u00e9rine et les maladies cardiaques.<\/p>\n

Enfin, le laboratoire du Dr Francis Collins, qui a d\u00e9couvert le g\u00e8ne de la prog\u00e9ria, a progress\u00e9 et produit une souris atteinte de la prog\u00e9ria qui pr\u00e9sente un d\u00e9faut g\u00e9n\u00e9tique identique \u00e0 celui des enfants. Ce mod\u00e8le de souris classique atteint de la prog\u00e9ria pr\u00e9sente une maladie vasculaire grave et sera essentiel \u00e0 notre compr\u00e9hension non seulement de la mani\u00e8re dont les enfants atteints de la prog\u00e9ria d\u00e9veloppent une maladie cardiaque, mais sera \u00e9galement un excellent mod\u00e8le pour tester de nouveaux traitements tels que la th\u00e9rapie FTI et les th\u00e9rapies g\u00e9n\u00e9tiques pour traiter et gu\u00e9rir la prog\u00e9ria. Ce mod\u00e8le peut \u00e9galement \u00eatre utilis\u00e9 pour \u00e9tudier les maladies cardiovasculaires en g\u00e9n\u00e9ral. Nous sommes fiers de dire que notre directeur m\u00e9dical, le Dr Leslie B. Gordon, est co-auteur. L'\u00e9tude est publi\u00e9e dans le num\u00e9ro de cette semaine de PNAS.<\/p>\n

Des copies des deux articles du PNAS sont disponibles sur le site Web des Proceedings of the National Academies of Science \u00e0 l'adresse www.pnas.org<\/a><\/p>\n

Trois \u00e9tudes en un mois \u2013 WOW ! Nous sommes vraiment en train de pr\u00e9parer le terrain pour trouver un rem\u00e8de. Merci \u00e0 tous les chercheurs qui travaillent dur chaque jour pour aider les enfants atteints de prog\u00e9ria et les millions de personnes qui souffrent de maladies cardiaques dans le monde. Et merci aux familles et aux enfants, ainsi qu\u2019\u00e0 tous nos donateurs pour avoir rendu tout cela possible.<\/strong><\/p>\n

ENSEMBLE, NOUS VOLONT\u00c9<\/em> TROUVEZ LE REM\u00c8DE!<\/strong><\/p>\n

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[vc_custom_heading text=\"Three studies released that bring us closer than ever to understanding Progeria and to disease treatment\" font_container=\"tag:h1|text_align:left\" use_theme_fonts=\"yes\"]PRF-funded, UCLA researchers have taken a Progeria-like mouse model and tested a potential drug treatment for children with Progeria. Their study released in Science Feb.16th has found that this FTI drug improves some signs of the disease.<\/p>

In September The Progeria Research Foundation was pleased to announce that PRF-funded researchers had published studies supporting a potential drug treatment for children with Progeria - Progeria cells became normalized (in a dish) when given this drug. The next phase of testing has been in animal models, and we are excited to report that a study released in Science Feb.16th has found that this FTI drug improves some signs of disease in a progeria-like mouse model. PRF helped fund UCLA researchers Dr. Loren Fong and Dr. Stephen Young for this latest, vital step towards clinical treatment trials with the children. Click here for more details<\/a> on this exciting news.<\/p>

And the scientific publications continue! PRF funded a study by Dr. Karima Djabali, along with Dr. Dayle McClintock and PRF Medical Director Dr. Leslie B. Gordon, which was just published in this week's PNAS (Proceeding of the National Academy of Sciences).<\/em> The study concludes that the defective protein produced by the Progeria gene (called progerin) builds up in cells of the children's vessel walls. This shows us, for the first tine, that there is a direct connection between progerin and heart disease.<\/p>

And last but certainly not least, the laboratory of Dr. Francis Collins, who discovered the gene for Progeria, has forged ahead and produced a Progeria mouse that carries a genetic defect identical to that of the children. This classic Progeria mouse model shows severe vascular disease, and will be pivotal to our understanding not only how children with Progeria develop heart disease, but even more importantly will be excellent models for testing new treatments such as FTI and genetic therapies in treating and curing Progeria, And this model can also be used to explore cardiovascular disease in general. We are proud to say that our Medical Director, Dr. Leslie B. Gordon, is a co-author. The study appears in this week's PNAS.<\/p>

Copies of both PNAS articles can be found at the website of the Proceedings of the National Academies of Science at www.pnas.org<\/a><\/p>

Three studies in one month - WOW! We are really cooking towards the cure. Thank you to all of those researchers who are working hard every day to help children with Progeria and the millions of people who suffer from heart disease throughout the world. And thanks to the families and children, and all of our donors for making this all possible.<\/strong><\/p>

TOGETHER, WE WILL<\/em> FIND THE CURE!<\/strong><\/p>","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-2113","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"yoast_head":"\nThree studies released that bring us closer than ever to understanding Progeria and to disease treatment - The Progeria Research Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.progeriaresearch.org\/fr\/2006\/02\/16\/three-studies-released-that-bring-us-closer-than-ever-to-understanding-progeria-and-to-disease-treatment\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Three studies released that bring us closer than ever to understanding Progeria and to disease treatment - The Progeria Research Foundation\" \/>\n<meta property=\"og:description\" content=\"[et_pb_section fb_built=”1″ _builder_version=”3.22″][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.6.5″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” hover_enabled=”0″ sticky_enabled=”0″] PRF-funded, UCLA researchers have taken a Progeria-like mouse model and tested a potential drug treatment for children with Progeria. 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