{"id":2128,"date":"2005-05-16T20:41:26","date_gmt":"2005-05-16T20:41:26","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?p=2128"},"modified":"2020-12-09T11:08:36","modified_gmt":"2020-12-09T16:08:36","slug":"exciting-news-on-potential-drug-treatments","status":"publish","type":"post","link":"https:\/\/www.progeriaresearch.org\/fr\/2005\/05\/16\/exciting-news-on-potential-drug-treatments\/","title":{"rendered":"Des nouvelles passionnantes sur les traitements m\u00e9dicamenteux potentiels"},"content":{"rendered":"

[et_pb_section fb_built=\u201d1\u2033 _builder_version=\u201d3.22\u2033][et_pb_row _builder_version=\u201d3.25\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201dr\u00e9p\u00e9ter\u201d][et_pb_column type=\u201d4_4\u2033 _builder_version=\u201d3.25\u2033 custom_padding=\u201d|||\u201d custom_padding__hover=\u201d|||\u201d][et_pb_text _builder_version=\u201d4.6.5\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201dr\u00e9p\u00e9ter\u201d hover_enabled=\u201d0\u2033 sticky_enabled=\u201d0\u2033]<\/p>\n

\n

Ao\u00fbt 2005 \u2013 f\u00e9vrier 2006 : Des chercheurs ont publi\u00e9 des \u00e9tudes qui soutiennent un traitement m\u00e9dicamenteux potentiel pour les enfants atteints de prog\u00e9ria. Les inhibiteurs de la farn\u00e9syltransf\u00e9rase (FTI), d\u00e9velopp\u00e9s \u00e0 l\u2019origine pour le cancer, sont capables d\u2019inverser les anomalies dramatiques de la structure nucl\u00e9aire qui caract\u00e9risent les cellules des enfants atteints de prog\u00e9ria.<\/p>\n

Voici quelques r\u00e9ponses aux questions fr\u00e9quemment pos\u00e9es sur les FTI et ces d\u00e9couvertes r\u00e9centes<\/a><\/strong><\/p>\n

Du laboratoire de Susan Michaelis \u00e0 la facult\u00e9 de m\u00e9decine de l'universit\u00e9 Johns Hopkins et \u00e0 l'universit\u00e9 de Seattle. Premier auteur : Monica Mallampalli.<\/a> Cette \u00e9tude a \u00e9t\u00e9 financ\u00e9e par le PRF.<\/em> Cliquez ici<\/a> pour l'article \"<\/p>\n

Du laboratoire du Dr Thomas Glover de l'Universit\u00e9 du Michigan.<\/a> Premier auteur : Michael W. Glynn. Cette \u00e9tude a \u00e9t\u00e9 financ\u00e9e par le PRF.<\/em> Cliquez ici<\/a> pour l'article \"<\/p>\n

Du laboratoire du Dr Francis Collins \u00e0 l'Institut national de recherche sur le g\u00e9nome humain : Premier auteur : Brian Capell.<\/a> Auteur suppl\u00e9mentaire : Dr Leslie Gordon, directrice m\u00e9dicale du PRF<\/em><\/p>\n

Capell BC, Erdos MR, Madigan JP, Fiordalisi JJ, Varga R, Conneely KN et al. L'inhibition de la farn\u00e9sylation de la prog\u00e9rine pr\u00e9vient la formation de bulles nucl\u00e9aires caract\u00e9ristiques du syndrome de prog\u00e9ria de Hutchinson-Gilford.<\/em> Proc Natl Acad Sci USA 2005;102(36):12879-84.<\/p>\n

Du laboratoire des Drs Loren Fong et Steven Young \u00e0 l'UCLA.<\/a> Le PRF a contribu\u00e9 au financement de cette \u00e9tude.<\/em><\/p>\n

Fong LG, Frost D, Meta M, Qiao X, Yang SH, Coffinier C, et al. Un inhibiteur de la prot\u00e9ine farn\u00e9syltransf\u00e9rase am\u00e9liore la maladie dans un mod\u00e8le murin de prog\u00e9ria.<\/em> Sciences 2006;311(5767):1621-3.<\/p>\n

Voici quelques-uns des nombreux m\u00e9dias qui ont couvert cette histoire :<\/strong><\/p>\n

ABCNEWS.COM<\/strong>
Des m\u00e9dicaments contre le cancer pourraient aider \u00e0 lutter contre une maladie rare qui provoque un vieillissement rapide : 29 septembre 2005 (article non disponible)
Los Angeles Times<\/strong>
Des recherches montrent que les m\u00e9dicaments pourraient bloquer les maladies li\u00e9es au vieillissement pr\u00e9coce (article non disponible)
FORBES <\/strong>
Des m\u00e9dicaments contre le cancer pourraient aider \u00e0 lutter contre le vieillissement rapide de la population (article non disponible)
REUTERS<\/strong>
Des m\u00e9dicaments contre le cancer pourraient traiter le syndrome de vieillissement chez les enfants (article non disponible)
HEALTHNEWSDIGEST.COM<\/strong>
Bloquer un syndrome de vieillissement pr\u00e9matur\u00e9 gr\u00e2ce \u00e0 des m\u00e9dicaments anticanc\u00e9reux (article non disponible)<\/p>\n<\/div>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”3.22″][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.6.5″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” hover_enabled=”0″ sticky_enabled=”0″] August 2005 \u2013February 2006: Researchers have published studies that support a potential drug treatment for children with Progeria. Farnesyltransferase inhibitors (FTIs), originally developed for cancer, are capable of reversing the dramatic nuclear structure abnormalities that are the hallmark […]<\/p>","protected":false},"author":1,"featured_media":2043,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"

[vc_custom_heading text=\"Exciting News on Potential Drug Treatments\" font_container=\"tag:h1|text_align:left\" use_theme_fonts=\"yes\"]<\/p>

August 2005 \u2013February 2006: Researchers have published studies that support a potential drug treatment for children with Progeria. Farnesyltransferase inhibitors (FTIs), originally developed for cancer, are capable of reversing the dramatic nuclear structure abnormalities that are the hallmark of cells from children with Progeria.<\/p>

Here are some answers to Frequently Asked Questions about FTI's and these recent findings<\/a><\/strong><\/p>

From the lab of Susan Michaelis at Johns Hopkins University School of Medicine and the University of Seattle. First author: Monica Mallampalli.<\/a> PRF funded this study.<\/em> Click here<\/a> for the article \"<\/p>

From the lab of Dr. Thomas Glover at the University of Michigan.<\/a> First author: Michael W. Glynn. PRF funded this study.<\/em> Click here<\/a> for the article \"<\/p>

From the lab of Dr. Francis Collins at the National Human Genome Research Institute: First author: Brian Capell.<\/a> Additional author: PRF's Medical Director Dr. Leslie Gordon<\/em><\/p>

Capell BC, Erdos MR, Madigan JP, Fiordalisi JJ, Varga R, Conneely KN, et al. Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome.<\/em> Proc Natl Acad Sci U S A 2005;102(36):12879-84.<\/p>

From the lab of Drs. Loren Fong and Steven Young at UCLA.<\/a> PRF helped fund this study.<\/em><\/p>

Fong LG, Frost D, Meta M, Qiao X, Yang SH, Coffinier C, et al. A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria.<\/em> Science 2006;311(5767):1621-3.<\/p>

Here are just a few of the many media outlets that have covered this story:<\/strong><\/p>

ABCNEWS.COM<\/strong>
Cancer Drugs May Fight Rare Rapid-Aging Disease: Sept.29, 2005<\/a> (article no longer available)
LA TIMES<\/strong>
Research Shows Drugs Could Block Early-Aging Disease<\/a>
FORBES <\/strong>
Cancer Drugs May Fight Rapid-Aging Disease<\/a>\u00a0(article no longer available)
REUTERS<\/strong>
Cancer Drugs May Treat Aging Syndrome in Children<\/a> (article no longer available)
HEALTHNEWSDIGEST.COM<\/strong>
Blocking a Premature Aging Syndrome with Anticancer Drugs<\/a>\u00a0(article no longer available)<\/p>
You will need the Adobe Acrobat Plugin to view and print forms. 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