{"id":21417,"date":"2026-03-03T08:00:33","date_gmt":"2026-03-03T13:00:33","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?p=21417"},"modified":"2026-03-03T07:09:53","modified_gmt":"2026-03-03T12:09:53","slug":"prfandforge","status":"publish","type":"post","link":"https:\/\/www.progeriaresearch.org\/fr\/2026\/03\/03\/prfandforge\/","title":{"rendered":"PRF annonce un partenariat de fabrication avec Forge Biologics pour faire progresser la th\u00e9rapie g\u00e9nique contre la prog\u00e9ria\u00a0!"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.27.4&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;-74px|auto||auto|false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Pttc&#8221; _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-20802 aligncenter\" style=\"display: block; margin-left: auto; margin-right: auto;\" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2025\/08\/PTCP_wPRF-1024x511.jpg\" alt=\"\" width=\"491\" height=\"245\" \/><\/p>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;Sam-Pro 2&#8243; _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>PRF a conclu un accord de fabrication avec\u00a0<a href=\"https:\/\/www.forgebiologics.com\/\">Forge Biologics\u00a0<\/a>produire\u00a0<strong>SamPro-2<\/strong> \u2013 La th\u00e9rapie exp\u00e9rimentale de modification g\u00e9n\u00e9tique de PRF, con\u00e7ue pour corriger la mutation g\u00e9n\u00e9tique responsable de la prog\u00e9ria.<\/p>\n<p>Il s&#039;agit d&#039;une \u00e9tape d\u00e9terminante vers les essais cliniques de th\u00e9rapie g\u00e9nique pour la prog\u00e9ria.<\/p>\n<h4><strong>Qu&#039;est-ce que SamPro-2 ?<\/strong><\/h4>\n<p><strong><\/strong>SamPro-2 est une th\u00e9rapie de modification g\u00e9n\u00e9tique de PRF con\u00e7ue pour corriger la mauvaise orthographe d&#039;une seule lettre d&#039;ADN qui cause la prog\u00e9ria.<\/p>\n<p>L&#039;ADN est le manuel d&#039;instructions du corps. Chez les enfants et les jeunes adultes atteints de prog\u00e9ria, une seule lettre de ce manuel est erron\u00e9e\u00a0: un \u201c\u00a0T\u00a0\u201d remplace un \u201c\u00a0C\u00a0\u201d. Cette substitution d&#039;une seule lettre entra\u00eene la production d&#039;une prot\u00e9ine toxique appel\u00e9e prog\u00e9rine, responsable de la maladie.<\/p>\n<p>SamPro-2 est con\u00e7u pour corriger cette erreur \u2014 en transformant d\u00e9finitivement le \u201c T \u201d en \u201c C \u201d \u2014 dans le but d&#039;arr\u00eater la maladie \u00e0 la source, au sein m\u00eame des cellules de l&#039;organisme.<\/p>\n<p>[\/et_pb_text][et_pb_testimonial quote_icon_color=&#8221;#FFFFFF&#8221; quote_icon_background_color=&#8221;#8FD2ED&#8221; admin_label=&#8221;Leslie Quote&#8221; _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; max_width=&#8221;65%&#8221; module_alignment=&#8221;center&#8221; min_height=&#8221;83px&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;1px||12px||false|false&#8221; border_radii=&#8221;on|35px|35px|35px|35px&#8221; border_width_all=&#8221;5px&#8221; border_color_all=&#8221;#00B2E2&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>&nbsp;<\/p>\n<p>\u00ab<em>L&#039;\u00e8re de la th\u00e9rapie g\u00e9nique pour la prog\u00e9ria est arriv\u00e9e. Nous esp\u00e9rons que SamPro-2 offrira aux enfants et aux jeunes adultes atteints de prog\u00e9ria la vie plus longue et plus saine qu&#039;ils m\u00e9ritent. Nous sommes extr\u00eamement reconnaissants de collaborer avec Forge Biologics, dont l&#039;expertise en mati\u00e8re de fabrication est essentielle pour faire passer ces travaux du laboratoire aux essais cliniques.<\/em>.\u201d<\/p>\n<p>Leslie Gordon, MD, Ph.D., cofondatrice et directrice m\u00e9dicale de PRF et m\u00e8re de Sam Berns, atteint de prog\u00e9ria<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-28 aligncenter\" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/PRF_Logo_2019_4color.png\" alt=\"\" width=\"333\" height=\"95\" srcset=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/PRF_Logo_2019_4color.png 595w, https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/PRF_Logo_2019_4color-300x86.png 300w\" sizes=\"(max-width: 333px) 100vw, 333px\" \/><\/p>\n<p>\u200b<\/p>\n<p>[\/et_pb_testimonial][et_pb_text admin_label=&#8221;PRF chose Forge&#8221; _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4><strong>Pourquoi PRF a choisi Forge pour fabriquer le SamPro-2<\/strong><\/h4>\n<p>Avant toute th\u00e9rapie g\u00e9nique pouvant \u00eatre administr\u00e9e \u00e0 une personne, celle-ci doit \u00eatre\u00a0:<\/p>\n<ul>\n<li>Fabriqu\u00e9 dans des installations ultra-propres et hautement sp\u00e9cialis\u00e9es<\/li>\n<li>Fabriqu\u00e9 selon les normes strictes actuelles de bonnes pratiques de fabrication (BPF).<\/li>\n<li>Test\u00e9 \u00e0 plusieurs reprises pour garantir la s\u00e9curit\u00e9, la puret\u00e9 et la constance<\/li>\n<li>Pr\u00e9par\u00e9 pour l&#039;examen r\u00e9glementaire de la FDA am\u00e9ricaine<\/li>\n<\/ul>\n<p>Forge Biologics est un chef de file dans la fabrication de th\u00e9rapies g\u00e9niques. Son expertise nous aidera \u00e0 faire passer SamPro-2 des avanc\u00e9es scientifiques majeures en laboratoire aux essais cliniques pour les enfants et les jeunes adultes atteints de prog\u00e9ria.<\/p>\n<p>La fabrication constitue le pont entre la d\u00e9couverte et le traitement.<\/p>\n<p>Ce partenariat jette ce pont.<\/p>\n<p>[\/et_pb_text][et_pb_testimonial quote_icon_color=&#8221;#FFFFFF&#8221; quote_icon_background_color=&#8221;#8FD2ED&#8221; admin_label=&#8221;Forge Quote&#8221; _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; max_width=&#8221;65%&#8221; module_alignment=&#8221;center&#8221; min_height=&#8221;83px&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;1px||12px||false|false&#8221; border_radii=&#8221;on|35px|35px|35px|35px&#8221; border_width_all=&#8221;5px&#8221; border_color_all=&#8221;#00B2E2&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>&nbsp;<\/p>\n<p>\u00ab<em>Derri\u00e8re chaque programme de ce type se cachent des patients et leurs familles qui attendent depuis longtemps des progr\u00e8s. La Fondation pour la recherche sur la prog\u00e9ria et son \u00e9quipe de g\u00e9n\u00e9tique ont fait preuve d&#039;un d\u00e9vouement exceptionnel pour faire progresser la science, et nous sommes honor\u00e9s de collaborer avec elles. Chez Forge, nous apportons le m\u00eame niveau d&#039;attention, d&#039;expertise et de rigueur technique \u00e0 notre production, contribuant ainsi \u00e0 l&#039;avancement de ce programme pour les patients.\u201d<\/em><\/p>\n<p>~John Maslowski, pr\u00e9sident et directeur g\u00e9n\u00e9ral de Forge Biologics<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-21424 aligncenter\" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2026\/03\/Forge-Logo-1024x511.png\" alt=\"\" width=\"271\" height=\"135\" \/><\/p>\n<p>\u200b<\/p>\n<p>[\/et_pb_testimonial][et_pb_text admin_label=&#8221;Progeria Gene Dream Team&#8221; _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4><strong>L&#039;\u00e9quipe g\u00e9n\u00e9tique de la prog\u00e9ria<\/strong><\/h4>\n<p>La PRF et ses collaborateurs, collectivement connus sous le nom de Progeria Gene Team, ont cr\u00e9\u00e9 SamPro-2. La Progeria Gene Team r\u00e9unit des leaders internationalement reconnus en g\u00e9n\u00e9tique, en m\u00e9decine clinique et en innovation biom\u00e9dicale, tous anim\u00e9s par un engagement commun : trouver un rem\u00e8de \u00e0 la prog\u00e9ria.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-21425 aligncenter\" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2026\/03\/GeneTeamforge-page-1024x414.jpg\" alt=\"\" width=\"734\" height=\"297\" \/><\/p>\n<p><strong>Dr Francis S. Collins, Ph. D.<\/strong><br \/>Conseiller principal en recherche aupr\u00e8s de la PRF et ancien directeur des National Institutes of Health, il a dirig\u00e9 le projet du g\u00e9nome humain \u2014 l&#039;une des r\u00e9alisations scientifiques les plus importantes de notre \u00e9poque \u2014 et a contribu\u00e9 \u00e0 faire entrer la g\u00e9n\u00e9tique dans l&#039;\u00e8re moderne.<\/p>\n<p><strong>Dr Leslie Gordon, Ph. D.<\/strong><br \/>Cofondatrice et directrice m\u00e9dicale de PRF, experte mondiale de la prog\u00e9ria, elle est \u00e0 l&#039;origine de toutes les avanc\u00e9es majeures dans ce domaine. Le Dr Gordon est \u00e9galement la m\u00e8re de Sam, dont la vie a inspir\u00e9 la cr\u00e9ation de PRF et continue d&#039;alimenter son engagement.<\/p>\n<p><strong>David R. Liu, Ph. D.<\/strong><br \/>Richard Merkin est professeur et directeur de l&#039;Institut Merkin pour les technologies transformatrices en sant\u00e9 au Broad Institute du MIT et de Harvard. Le Dr Liu est un pionnier mondialement reconnu de l&#039;\u00e9dition g\u00e9nique et un chef de file international dans le d\u00e9veloppement des technologies d&#039;\u00e9dition de base qui r\u00e9volutionnent la m\u00e9decine moderne.<\/p>\n<p><strong>Le regrett\u00e9 Sammy Basso, MS<\/strong><br \/>Scientifique, militant et membre exceptionnel de la communaut\u00e9 mondiale de la prog\u00e9ria, Sammy Basso a toujours \u00e9t\u00e9 une source d&#039;inspiration et un guide pr\u00e9cieux pour la recherche. Son intelligence, son courage et son engagement ind\u00e9fectible envers l&#039;avancement de la recherche continuent de faire progresser ce travail. Sammy \u00e9tait l&#039;ambassadeur international de la PRF. Avec sa famille, il a cr\u00e9\u00e9 l&#039;Associazione Italiana Progeria Sammy Basso (AIPro.Sa.B.) afin de contribuer \u00e0 la recherche d&#039;un traitement contre la prog\u00e9ria.<\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;why turning point&#8221; _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4><strong>Pourquoi il s&#039;agit d&#039;un tournant<\/strong><\/h4>\n<p>Pour les familles, cela repr\u00e9sente un \u00e9lan concret.<\/p>\n<p>Pour les donateurs, voici l&#039;impact de votre investissement dans une science audacieuse.<\/p>\n<p>Pour la communaut\u00e9 plus large des maladies rares, cela repr\u00e9sente l&#039;un des efforts les plus avanc\u00e9s \u00e0 ce jour pour corriger une maladie p\u00e9diatrique multisyst\u00e9mique mortelle \u00e0 sa source g\u00e9n\u00e9tique.<\/p>\n<p>Il nous reste encore beaucoup de travail \u00e0 accomplir. Mais c&#039;est un grand pas en avant. Et chaque pas nous rapproche de notre vision. <strong>Un monde o\u00f9 chaque enfant atteint de prog\u00e9ria est gu\u00e9ri.<\/strong><\/p>\n<p><a href=\"https:\/\/www.progeriaresearch.org\/fr\/press-room\/\"><strong>Lire le communiqu\u00e9 de presse ici<\/strong><\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"<p>PRF annonce un partenariat de fabrication avec Forge Biologics pour faire progresser la th\u00e9rapie g\u00e9nique contre la prog\u00e9ria\u00a0!<br \/>\nCette annonce marque une \u00e9tape majeure\u00a0: PRF a conclu un accord de fabrication avec Forge Biologics pour produire SamPro-2, sa th\u00e9rapie d\u2019\u00e9dition g\u00e9nique en d\u00e9veloppement pour les enfants et les jeunes adultes atteints de prog\u00e9ria \u2014 une \u00e9tape essentielle vers les essais cliniques et, finalement, la gu\u00e9rison\u00a0! <\/p>","protected":false},"author":2,"featured_media":21431,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[11,2,1],"tags":[],"class_list":["post-21417","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-homepage-news","category-news","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>PRF Partnership with Forge I The Progeria Research Foundation<\/title>\n<meta name=\"description\" content=\"PRF Announces Manufacturing Partnership with Forge Biologics to Advance Progeria Gene Therapy! This announcement marks a major milestone: PRF has entered into a manufacturing agreement with Forge Biologics to produce SamPro-2, its gene editing therapy in development for children and young adults with Progeria -- an essential step toward clinical trials and, ultimately, the cure!\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.progeriaresearch.org\/fr\/2026\/03\/03\/prfandforge\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PRF Partnership with Forge I The Progeria Research Foundation\" \/>\n<meta property=\"og:description\" content=\"PRF Announces Manufacturing Partnership with Forge Biologics to Advance Progeria Gene Therapy! This announcement marks a major milestone: PRF has entered into a manufacturing agreement with Forge Biologics to produce SamPro-2, its gene editing therapy in development for children and young adults with Progeria -- an essential step toward clinical trials and, ultimately, the cure!\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.progeriaresearch.org\/fr\/2026\/03\/03\/prfandforge\/\" \/>\n<meta property=\"og:site_name\" content=\"The Progeria Research Foundation\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ProgeriaResearch\/\" \/>\n<meta property=\"article:published_time\" content=\"2026-03-03T13:00:33+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2026\/03\/PtTCwprf.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1000\" \/>\n\t<meta property=\"og:image:height\" content=\"1000\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Karen Betournay\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@Progeria\" \/>\n<meta name=\"twitter:site\" content=\"@Progeria\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Karen Betournay\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.progeriaresearch.org\/2026\/03\/03\/prfandforge\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/2026\/03\/03\/prfandforge\/\"},\"author\":{\"name\":\"Karen Betournay\",\"@id\":\"https:\/\/www.progeriaresearch.org\/ta\/#\/schema\/person\/2be6cec85c11aaef7a7602636c5b9946\"},\"headline\":\"PRF Announces Manufacturing Partnership with Forge Biologics to Advance Progeria Gene Therapy!\",\"datePublished\":\"2026-03-03T13:00:33+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/2026\/03\/03\/prfandforge\/\"},\"wordCount\":1004,\"publisher\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/ta\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/2026\/03\/03\/prfandforge\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2026\/03\/PtTCwprf.jpg\",\"articleSection\":[\"Homepage News\",\"News\",\"Uncategorized\"],\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.progeriaresearch.org\/2026\/03\/03\/prfandforge\/\",\"url\":\"https:\/\/www.progeriaresearch.org\/2026\/03\/03\/prfandforge\/\",\"name\":\"PRF Partnership with Forge I The Progeria Research Foundation\",\"isPartOf\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/ta\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/2026\/03\/03\/prfandforge\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/2026\/03\/03\/prfandforge\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2026\/03\/PtTCwprf.jpg\",\"datePublished\":\"2026-03-03T13:00:33+00:00\",\"description\":\"PRF Announces Manufacturing Partnership with Forge Biologics to Advance Progeria Gene Therapy! 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