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Children with Progeria are genetically predisposed to premature, progressive heart disease. Death occurs almost exclusively due to widespread heart disease, the leading cause of death in the US, and #2 worldwide. As with any person suffering from heart disease, the common events for Progeria children are strokes, high blood pressure, angina, enlarged heart, and heart failure, all conditions associated with aging.<\/p>\n
[\/et_pb_text][et_pb_testimonial author=”Dr. Samer Najjar” job_title=”Head of the Human Cardiovascular Studies Unit ” company_name=”The National Institute on Aging” quote_icon_color=”#00b2e2″ portrait_width=”140px” portrait_height=”140px” admin_label=”Dr. Samer Najjar Quote” _builder_version=”4.16″ background_color=”#f7f7f7″ custom_margin=”50px||” custom_margin_tablet=”” custom_margin_phone=”” custom_margin_last_edited=”on|desktop” z_index_tablet=”500″ custom_css_testimonial_author=”color: #00b2e2;||font-size: 19px !important;||font-weight: 700;” custom_css_testimonial_meta=”font-style: italic;||font-weight: 700;” box_shadow_style_image=”preset3″ locked=”off” global_colors_info=”{}”]<\/p>\n
\u00a0“These children get heart disease at an incredibly accelerated pace, usually by the time they are 12, 13 or 14. In the general community, the prevalence of cardiovascular disease starts appearing in the 60s and 70s. Obviously, there’s some process that’s accelerated.”<\/p>\n
[\/et_pb_testimonial][et_pb_text _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”]<\/p>\n
Thus there is clearly a tremendous need for research in Progeria. Because finding a cure for Progeria will not only help these children, but may provide keys for treating millions of adults with heart disease and stroke associated with the natural aging process<\/em>.<\/p>\n Click here to find out more about the research that suggests a link between Progeria and normal aging.\u00a0<\/a><\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”]<\/p>\n <\/p>\n Because the aging process is accelerated in children with Progeria, they offer researchers a rare opportunity to observe in just a few years what would otherwise require decades of longitudinal studies.<\/p>\n [\/et_pb_text][et_pb_testimonial author=”Dr. Huber Warner” job_title=”Associate Director” company_name=”The National Institute on Aging” quote_icon_color=”#00b2e2″ portrait_width=”140px” portrait_height=”140px” admin_label=”Dr. Huber Warner Quote” _builder_version=”4.16″ background_color=”#f7f7f7″ custom_margin=”50px||” custom_margin_tablet=”” custom_margin_phone=”” custom_margin_last_edited=”on|desktop” z_index_tablet=”500″ custom_css_testimonial_author=”color: #00b2e2;||font-size: 19px !important;||font-weight: 700;” custom_css_testimonial_meta=”font-style: italic;||font-weight: 700;” box_shadow_style_image=”preset3″ locked=”off” global_colors_info=”{}”]<\/p>\n “A better understanding of the causes of this syndrome (Progeria) could lead to better insights into the mechanisms of both development and aging.”\u00a0<\/p>\n [\/et_pb_testimonial][et_pb_testimonial author=”Dr. Vilhelm Bohr” job_title=”Chairman of Molecular Gerontology” company_name=”The National Institute on Aging” quote_icon_color=”#00b2e2″ portrait_width=”140px” portrait_height=”140px” admin_label=”Dr. Vilhelm Bohr Quote” _builder_version=”4.16″ background_color=”#f7f7f7″ custom_margin=”50px||” custom_margin_tablet=”” custom_margin_phone=”” custom_margin_last_edited=”on|desktop” z_index_tablet=”500″ custom_css_testimonial_author=”color: #00b2e2;||font-size: 19px !important;||font-weight: 700;” custom_css_testimonial_meta=”font-style: italic;||font-weight: 700;” box_shadow_style_image=”preset3″ locked=”off” global_colors_info=”{}”]<\/p>\n “It’s amazing how much Progeria resembles the normal aging process. I think these proteins linked to Progeria play a very profound role in the aging process, and I think we’ve already seen some pretty big findings in terms of what these proteins do.”<\/p>\n [\/et_pb_testimonial][et_pb_text _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”]<\/p>\n <\/p>\n Children with Progeria also develop and die of atherosclerosis and arteriosclerosis (commonly referred to as heart disease). Atherosclerosis is just one of several types of “arterio”-sclerosis, which is characterized by thickening and hardening of the arteries, but the two terms are often used to mean the same thing. Some hardening of the arteries often occurs when people grow older.<\/p>\n Atherosclerosis involves deposits of fatty substances in the inner lining of an artery. This buildup is called plaque. Plaques can grow large enough to significantly reduce the flow of blood through an artery, or plaques become fragile and rupture to form clots that can block blood flow. If the blockage occurs to an artery that feeds into the heart, it causes a heart attack<\/em>. If the blockage occurs to an artery that feeds into the brain, it causes a stroke<\/em>. Atherosclerosis is not only the cause of death among children with Progeria, but also the leading cause of death in the United States and many other parts of the world in normal aging individuals<\/em>. It is our hope that the discovery of the Progeria gene will have a beneficial effect not only for Progeria patients, but also for the millions of people affected by aging-related conditions, including heart attacks and stroke caused by atherosclerosis and arteriosclerosis.<\/p>\n [\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][\/et_pb_section][et_pb_section fb_built=”1″ module_class=”footer” _builder_version=”4.21.0″ background_color=”#29327a” custom_margin=”-2px|||||” custom_padding=”0|0px|0|0px|false|false” z_index_tablet=”500″ border_width_top=”12px” border_color_top=”#00b2e2″ global_module=”133″ locked=”off” global_colors_info=”{}”][et_pb_row column_structure=”1_4,1_4,1_2″ make_equal=”on” module_class=” et_pb_row_fullwidth” _builder_version=”4.16″ width=”89%” width_tablet=”80%” width_phone=”” width_last_edited=”on|desktop” max_width=”89%” max_width_tablet=”80%” max_width_phone=”” max_width_last_edited=”on|desktop” z_index_tablet=”500″ make_fullwidth=”on” 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strip 5″ _builder_version=”4.21.0″ _module_preset=”default” custom_margin=”35px||||false|false” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" [et_pb_section fb_built=”1″ fullwidth=”on” disabled_on=”off|off|off” _builder_version=”4.16″ border_width_bottom=”55px” border_color_bottom=”#29327a” global_colors_info=”{}”][et_pb_fullwidth_header _builder_version=”4.16″ title_font_size=”55″ background_color=”#29327a” background_image=”https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/About-Header.jpg” background_position=”center_left” custom_padding=”9vw||9vw||true” custom_padding_tablet=”” custom_padding_phone=”|56px||” custom_padding_last_edited=”on|desktop” title_font_size_tablet=”45px” title_font_size_phone=”40px” title_font_size_last_edited=”on|phone” z_index_tablet=”500″ custom_css_main_element=”background-position: center 18% !important;” global_colors_info=”{}”] The Connection to Other Diseases [\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ use_custom_gutter=”on” gutter_width=”1″ specialty=”on” padding_left_1=”35px” padding_left_2=”35px” padding_2_tablet=”|||0px” padding_2_phone=”|||0px” padding_2_last_edited=”on|desktop” module_class_1=”sidebar-secondary-nav” module_class=”handprint-bg” _builder_version=”4.16″ background_image=”https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/blue-handprint-only.png” parallax=”on” parallax_method=”off” inner_width=”100%” inner_max_width=”100%” custom_padding=”0|0px|54px|0px|false|false” z_index_tablet=”500″ border_width_top=”10px” border_color_top=”#8fd2ed” use_custom_width=”on” width_unit=”off” […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"\t\t\t\t[vc_row][vc_column][vc_custom_heading text=\"Connection to Other Diseases\" font_container=\"tag:h1|text_align:center\" use_theme_fonts=\"yes\"][vc_column_text]\r\nAtherosclerosis<\/h1>\n
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Aging<\/h1>\r\nChildren with Progeria are genetically predisposed to premature, progressive heart disease. Death occurs almost exclusively due to widespread heart disease, the leading cause of death in the US, and #2 worldwide. As with any person suffering from heart disease, the common events for Progeria children are strokes, high blood pressure, angina, enlarged heart, and heart failure, all conditions associated with aging.[\/vc_column_text][vc_column_text]\"These children get heart disease at an incredibly accelerated pace, usually by the time they are 12, 13 or 14. In the general community, the prevalence of cardiovascular disease starts appearing in the 60s and 70s. Obviously, there's some process that's accelerated.\"\r\n\r\n\u2014 Dr. Samer Najjar, head of the Human Cardiovascular Studies Unit at the National Institute on Aging[\/vc_column_text][vc_column_text]Thus there is clearly a tremendous need for research in Progeria. Because finding a cure for Progeria will not only help these children, but may provide keys for treating millions of adults with heart disease and stroke associated with the natural aging process<\/em>.\r\n\r\nBecause the aging process is accelerated in children with Progeria, they offer researchers a rare opportunity to observe in just a few years what would otherwise require decades of longitudinal studies.\r\n\r\n\"A better understanding of the causes of this syndrome (Progeria) could lead to better insights into the mechanisms of both development and aging.\" - National Institute of Aging Associate Director Dr. Huber Warner\r\n\r\nClick here to find out more about the research that suggests a link between Progeria and normal aging<\/a>[\/vc_column_text][vc_column_text]\"It's amazing how much Progeria resembles the normal aging process. I think these proteins linked to Progeria play a very profound role in the aging process, and I think we've already seen some pretty big findings in terms of what these proteins do.\r\n\r\n\u2014 Dr. Vilhelm Bohr, chairman of molecular gerontology at the National Institute on Aging[\/vc_column_text][vc_column_text]\r\n
Atherosclerosis<\/h1>\r\nChildren with Progeria also develop and die of atherosclerosis and arteriosclerosis (commonly referred to as heart disease). Atherosclerosis is just one of several types of \"arterio\"-sclerosis, which is characterized by thickening and hardening of the arteries, but the two terms are often used to mean the same thing. Some hardening of the arteries often occurs when people grow older.\r\n\r\nAtherosclerosis involves deposits of fatty substances in the inner lining of an artery. This buildup is called plaque. Plaques can grow large enough to significantly reduce the flow of blood through an artery, or plaques become fragile and rupture to form clots that can block blood flow. If the blockage occurs to an artery that feeds into the heart, it causes a heart attack<\/em>. If the blockage occurs to an artery that feeds into the brain, it causes a stroke<\/em>. Atherosclerosis is not only the cause of death among children with Progeria, but also the leading cause of death in the United States and many other parts of the world in normal aging individuals<\/em>. It is our hope that the discovery of the Progeria gene will have a beneficial effect not only for Progeria patients, but also for the millions of people affected by aging-related conditions, including heart attacks and stroke caused by atherosclerosis and arteriosclerosis.[\/vc_column_text][\/vc_column][\/vc_row]\t\t","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-770","page","type-page","status-publish","hentry"],"yoast_head":"\n