[{"id":18590,"date":"2026-06-30T09:30:52","date_gmt":"2026-06-30T13:30:52","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?p=18590"},"modified":"2026-06-30T09:40:12","modified_gmt":"2026-06-30T13:40:12","slug":"workshop2025","status":"publish","type":"post","link":"https:\/\/www.progeriaresearch.org\/workshop2025\/","title":{"rendered":"\u05d4\u05e1\u05d3\u05e0\u05d4 \u05d4\u05de\u05d3\u05e2\u05d9\u05ea \u05d4\u05d1\u05d9\u05e0\u05dc\u05d0\u05d5\u05de\u05d9\u05ea \u05d4-12 \u05e9\u05dc PRF"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; disabled_on=&#8221;off|off|off&#8221; _builder_version=&#8221;4.16&#8243; border_width_bottom=&#8221;55px&#8221; border_color_bottom=&#8221;#29327a&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_fullwidth_image src=&#8221;https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2024\/09\/PRF_ScientificMeetingBanner_2025_Final.jpg&#8221; title_text=&#8221;PRF_ScientificMeetingBanner_2025_Final&#8221; _builder_version=&#8221;4.27.0&#8243; z_index_tablet=&#8221;500&#8243; global_colors_info=&#8221;{}&#8221;]<br \/>\n[\/et_pb_fullwidth_image][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;1&#8243; specialty=&#8221;on&#8221; padding_left_1=&#8221;35px&#8221; padding_left_2=&#8221;35px&#8221; padding_2_tablet=&#8221;|||0px&#8221; padding_2_phone=&#8221;|||0px&#8221; padding_2_last_edited=&#8221;on|desktop&#8221; module_class_1=&#8221;sidebar-secondary-nav&#8221; module_class=&#8221;handprint-bg&#8221; _builder_version=&#8221;4.16&#8243; background_image=&#8221;https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/blue-handprint-only.png&#8221; parallax=&#8221;on&#8221; parallax_method=&#8221;off&#8221; inner_width=&#8221;100%&#8221; inner_max_width=&#8221;100%&#8221; custom_margin=&#8221;-65px|||||&#8221; custom_padding=&#8221;0|0px|0px|0px|false|false&#8221; z_index_tablet=&#8221;500&#8243; border_width_top=&#8221;10px&#8221; border_color_top=&#8221;#8fd2ed&#8221; use_custom_width=&#8221;on&#8221; width_unit=&#8221;off&#8221; custom_width_percent=&#8221;100%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_sidebar area=&#8221;et_pb_widget_area_32&#8243; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Workshop 2025&#8243; module_class=&#8221;subpage-sidebars&#8221; _builder_version=&#8221;4.24.0&#8243; _dynamic_attributes=&#8221;link_option_url&#8221; animation_style=&#8221;fade&#8221; link_option_url=&#8221;@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wb3N0Iiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjEyODc3In19@&#8221; z_index_tablet=&#8221;500&#8243; border_width_right=&#8221;5px&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<br \/>\n[\/et_pb_sidebar][\/et_pb_column][et_pb_column type=&#8221;3_4&#8243; specialty_columns=&#8221;3&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_row_inner custom_padding_last_edited=&#8221;on|phone&#8221; _builder_version=&#8221;4.27.6&#8243; min_height=&#8221;1112.5px&#8221; custom_padding=&#8221;39.4375px|35px|35px||false|false&#8221; custom_padding_tablet=&#8221;|35px||35px||true&#8221; custom_padding_phone=&#8221;&#8221; animation_direction=&#8221;top&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column_inner saved_specialty_column_type=&#8221;3_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;Reaching title&#8221; _builder_version=&#8221;4.27.6&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;20px&#8221; border_color_all=&#8221;#00B2E2&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h1 style=\"text-align: left;\"><strong>Reaching for the Cure as Progeria Research Comes of Age at the 12th International Scientific Workshop<\/strong><\/h1>\n<p><span style=\"color: #d07837;\"><strong>Maria Eriksson,\u00a0Vicente Andr\u00e9s,\u00a0Mark W. Kieran\u00a0&amp;\u00a0Leslie B. Gordon<\/strong><\/span><\/p>\n<p><span>PRF Scientific Workshop Summary Published in <\/span><strong><i>N<\/i><i>ature Aging<\/i><\/strong><span>\u00a0defines 6 strategic pillars for Progeria research!<\/span><\/p>\n<p>Two and a half days of groundbreaking science, powerful human connection, and renewed commitment to finding the cure.<\/p>\n<p>[\/et_pb_text][et_pb_image src=&#8221;https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2026\/06\/Screenshot-2026-06-20-at-8.45.53-AM.png&#8221; title_text=&#8221;Screenshot 2026-06-20 at 8.45.53\u202fAM&#8221; align=&#8221;center&#8221; admin_label=&#8221;3 image&#8221; _builder_version=&#8221;4.27.6&#8243; _module_preset=&#8221;default&#8221; width=&#8221;80%&#8221; max_width=&#8221;80%&#8221; custom_padding=&#8221;|30px||30px|false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text admin_label=&#8221;Table&#8221; _builder_version=&#8221;4.27.6&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;18px&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;10px|30px|10px|30px|false|false&#8221; border_color_all=&#8221;#00B2E2&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<table class=\"aligncenter\" style=\"width: 100%; border-style: solid; border-color: #d07837; background-color: #5b95f4;\" border=\"5\" cellpadding=\"5\">\n<tbody>\n<tr>\n<td style=\"width: 25%; text-align: center;\"><strong><span style=\"color: #ffffff;\">120<\/span><\/strong><br \/><strong><span style=\"color: #ffffff;\">PHYSICIANS, SCIENTISTS &amp; ADVOCATES<\/span><\/strong><\/td>\n<td style=\"width: 25%; text-align: center;\"><span style=\"color: #ffffff;\"><strong>16<\/strong><\/span><br \/><span style=\"color: #ffffff;\"><strong>\u00a0 COUNTRIES REPRESENTED\u00a0\u00a0<\/strong><\/span><\/td>\n<td style=\"width: 25%; text-align: center;\"><span style=\"color: #ffffff;\"><strong>50+<\/strong><\/span><br \/><span style=\"color: #ffffff;\"><strong>SCIENTIFIC PRESENTATIONS<\/strong><\/span><\/td>\n<td style=\"width: 25%; text-align: center;\"><span style=\"color: #ffffff;\"><strong>6<br \/><\/strong><strong>STRATEGIC PRIORITIES<\/strong><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;Official Meeting&#8221; _builder_version=&#8221;4.27.6&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;20px&#8221; border_color_all=&#8221;#00B2E2&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><strong>OFFICIAL MEETING REPORT \u2013 FREE ACCESS<\/strong><\/p>\n<p><em><strong>&#8220;<\/strong><\/em><em><strong>Reaching for the cure as progeria research comes of age at the 12th international scientific workshop<\/strong><\/em><em><strong>&#8220;<\/strong><\/em><\/p>\n<p>Our comprehensive meeting summary covering current treatments, cardiovascular disease, gene therapy advances, and six strategic priorities moving forward has been published in\u00a0<strong><em>Nature Aging<\/em><\/strong><strong> and is free to read and share<\/strong>.<\/p>\n<p>[\/et_pb_text][et_pb_button button_url=&#8221;https:\/\/rdcu.be\/fo5ak&#8221; button_text=&#8221;Read the Full Article&#8221; admin_label=&#8221;Read the full article the Springer Nature SharedIt link&#8221; _builder_version=&#8221;4.27.6&#8243; _module_preset=&#8221;default&#8221; button_text_size=&#8221;18px&#8221; button_border_color=&#8221;#FE5F55&#8243; background_layout=&#8221;dark&#8221; custom_padding=&#8221;10px||10px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_button][et_pb_text admin_label=&#8221;SCIENCE MEETS HUMANITY&#8221; _builder_version=&#8221;4.27.6&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;20px&#8221; border_color_all=&#8221;#00B2E2&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><strong>SCIENCE MEETS HUMANITY<\/strong><\/p>\n<p>The workshop opened with an unprecedented patient panel composed entirely of young adults living with Progeria. <strong>Merlin, Kaylee, Amber<\/strong>, and <strong>Michiel<\/strong> shared powerful insights into participating in clinical trials and navigating life with Progeria from childhood to adulthood. Their candid discussion captured the attention, hearts, and inspiration of everyone in the room.<\/p>\n<p>Attendees were also moved by a tribute to <strong>Sammy Basso<\/strong>, beloved patient and advocate, whose own words were shared through a film created by his best friend Riccardo. The evening closed with a musical performance by <strong>Dr. Francis Collins<\/strong>, former NIH Director and 20-year contributor to Progeria research.<\/p>\n<p>[\/et_pb_text][et_pb_button button_url=&#8221;https:\/\/youtu.be\/ImBKc6uCnk8&#8243; button_text=&#8221;Watch the panel discussion here&#8221; admin_label=&#8221;Watch the panel discussion here&#8221; _builder_version=&#8221;4.27.6&#8243; _module_preset=&#8221;default&#8221; button_text_size=&#8221;18px&#8221; button_border_color=&#8221;#FE5F55&#8243; background_layout=&#8221;dark&#8221; custom_padding=&#8221;10px||10px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_button][et_pb_text admin_label=&#8221;BUILT ON COLLABORATION&#8221; _builder_version=&#8221;4.27.6&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;20px&#8221; border_color_all=&#8221;#00B2E2&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><strong>BUILT ON COLLABORATION<\/strong><\/p>\n<p>The workshop closed in a circle \u2013 literally &#8211; with an open. reflective conversation about where the field goes next. The Progeria research community aligned around six strategic priorities to guide development of novel therapies for Progeria. Read the full details in the <em>Nature Aging<\/em> report.<\/p>\n<p>[\/et_pb_text][et_pb_image src=&#8221;https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2026\/06\/Screenshot-2026-06-19-at-5.16.12-PM.png&#8221; title_text=&#8221;Screenshot 2026-06-19 at 5.16.12\u202fPM&#8221; admin_label=&#8221;strategic Pillars image&#8221; _builder_version=&#8221;4.27.6&#8243; _module_preset=&#8221;default&#8221; width=&#8221;70%&#8221; max_width=&#8221;70%&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text admin_label=&#8221;Moments&#8221; _builder_version=&#8221;4.27.6&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;20px&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Moments like this are what make PRF\u2019s workshops so special. They create space for openness, collaboration, and a shared commitment to moving science forward, TOGETHER!<\/p>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;presenting sponsors&#8221; _builder_version=&#8221;4.27.6&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||1px|||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3 style=\"text-align: center;\"><\/h3>\n<h3 style=\"text-align: center;\">Presenting Sponsors<\/h3>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.aiprosab.org\/en\/home-english\/\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-20462 size-large alignleft\" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2025\/05\/APS-ONLUS-LOGO-1024x372.png\" alt=\"\" width=\"446\" height=\"162\" \/><\/a> <a href=\"https:\/\/www.nia.nih.gov\/\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-20994 alignright size-full\" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2025\/09\/NIH_NIA_Master_Logo_2Color_8c3db02c789aac09497d19c3bbf7ce48.png\" alt=\"\" width=\"528\" height=\"139\" srcset=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2025\/09\/NIH_NIA_Master_Logo_2Color_8c3db02c789aac09497d19c3bbf7ce48.png 528w, https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2025\/09\/NIH_NIA_Master_Logo_2Color_8c3db02c789aac09497d19c3bbf7ce48-480x126.png 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) 528px, 100vw\" \/><\/a><\/p>\n<p>[\/et_pb_text][et_pb_text disabled_on=&#8221;on|on|on&#8221; _builder_version=&#8221;4.27.6&#8243; text_text_color=&#8221;#000000&#8243; header_font=&#8221;||on||||||&#8221; header_text_color=&#8221;#00b2e2&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;|30px|30px||false|false&#8221; z_index_tablet=&#8221;500&#8243; border_color_bottom=&#8221;#8FD2ED&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-21699 aligncenter size-large\" style=\"float: right;\" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2026\/05\/d9a7ab76-443d-4ada-9d2c-a0f356c8cd4f-1024x679.jpg\" alt=\"\" width=\"414\" height=\"275\" \/>PRF&#8217;s 12th International Scientific Workshop: Breakthroughs, Community &amp; Hope<\/strong><\/p>\n<p>In October 2025, <strong>118<\/strong> physicians, scientists, and advocates from <strong>12<\/strong> countries gathered in Boston for The Progeria Research Foundation&#8217;s 12th International Scientific Workshop \u2014 two and a half days of groundbreaking science, powerful human connection, and renewed commitment to finding a cure.<\/p>\n<p><strong>Science Meets Humanity<\/strong> The workshop opened with an historic first: a patient panel composed entirely of young adults living with Progeria. Merlin, Kaylee, Amber, and Michiel shared powerful insights into participating in clinical trials and navigating life with Progeria from childhood to adulthood. Their candid discussion captured the attention, hearts, and inspiration of everyone in the room. Attendees were also moved by a tribute to Sammy Basso, beloved patient and advocate, whose own words were shared through a film created by his best friend Riccardo. The evening closed with a musical performance by Dr. Francis Collins, former NIH Director and 20-year contributor to Progeria research.<\/p>\n<p>[\/et_pb_text][et_pb_text disabled_on=&#8221;on|on|on&#8221; admin_label=&#8221;cutting edge&#8221; _builder_version=&#8221;4.27.6&#8243; text_text_color=&#8221;#000000&#8243; header_font=&#8221;||on||||||&#8221; header_text_color=&#8221;#00b2e2&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;|20px|||false|false&#8221; z_index_tablet=&#8221;500&#8243; border_color_bottom=&#8221;#8FD2ED&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span style=\"color: #000000;\"><strong>Cutting-Edge Research on Display<\/strong> Over 50 scientific presentations covered current treatments, cardiovascular disease, and the latest in gene therapy and gene editing. A highlight was the introduction of <strong>SamPro-2<\/strong>, a next-generation gene-editing therapy in development for a future clinical trial and a significant step toward a potential cure.<\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>Built on Collaboration<\/strong> From early-career mentorship sessions to high-energy poster discussions, the workshop fostered the kind of partnerships that accelerate science. It closed in a circle, literally, with an open and reflective conversation about where the field goes next. Moments like this are what make PRF\u2019s workshops so special. They create space for openness, collaboration, and a shared commitment to moving science forward, TOGETHER!<\/span><\/p>\n<p>[\/et_pb_text][et_pb_testimonial quote_icon_color=&#8221;#FFFFFF&#8221; quote_icon_background_color=&#8221;#00B2E2&#8243; disabled_on=&#8221;on|on|on&#8221; _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; border_radii=&#8221;on|30px|30px|30px|30px&#8221; border_width_all=&#8221;2px&#8221; border_color_all=&#8221;#00B2E2&#8243; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span style=\"color: #000000;\"><strong><u>What Attendees Are Saying<\/u><\/strong><\/span><\/p>\n<ul>\n<li><span style=\"color: #000000;\"><em>Honored to have had the opportunity to attend.<\/em><\/span><\/li>\n<li><span style=\"color: #000000;\"><em>I was impressed by the workshop organization and spirit! It felt being around family! Everyone was\u00a0 interested to communicate and share their experiences and ideas. The musical session by Dr. Colins broke the ice and added a more relaxed and enjoyable atmosphere to the conference. <\/em><\/span><\/li>\n<li><span style=\"color: #000000;\"><em>The combination of patient participation and high-quality scientific talks provided a comprehensive and up-to-date overview of the current state and future directions of progeria research.<\/em><\/span><\/li>\n<li><span style=\"color: #000000;\"><em>Unbelievable how much research is ongoing. So much hope<\/em><\/span><\/li>\n<li><span style=\"color: #000000;\"><em>Excellent workshop! Big thanks to the organizers! Good mix of clinical and preclinical topics. Great opportunities for networking, especially with the round tables.\u00a0<\/em><\/span><\/li>\n<li><span style=\"color: #000000;\"><em>Excellent workshop in every sense. Keep the format the same for future workshops.<\/em><\/span><\/li>\n<li><span style=\"color: #000000;\"><em>Exceptional and comprehensive overview of the most innovative advances in progeria research.<\/em><\/span><\/li>\n<li><span style=\"color: #000000;\"><em>The networking and collaborative time was extremely productive\u2014we initiated two promising collaboration opportunities during these sessions. I was reminded of the importance of working together with many people<\/em><\/span><\/li>\n<\/ul>\n<p>[\/et_pb_testimonial][et_pb_text disabled_on=&#8221;on|on|on&#8221; admin_label=&#8221;Survey Highlights&#8221; _builder_version=&#8221;4.27.6&#8243; text_text_color=&#8221;#000000&#8243; header_font=&#8221;||on||||||&#8221; header_text_color=&#8221;#00b2e2&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;|20px|30px||false|false&#8221; z_index_tablet=&#8221;500&#8243; border_width_bottom=&#8221;3px&#8221; border_color_bottom=&#8221;#8FD2ED&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><strong><u>Survey Highlights<\/u><\/strong><\/p>\n<ul>\n<li>92% of attendees gave the workshop a 5-star overall rating<\/li>\n<li>All scientific sessions received 4.9\u20135.0 ratings for quality, relevance, and speaker effectiveness<\/li>\n<\/ul>\n<p>[\/et_pb_text][et_pb_text disabled_on=&#8221;on|on|on&#8221; admin_label=&#8221;Sponsor TY&#8221; _builder_version=&#8221;4.27.5&#8243; text_text_color=&#8221;#000000&#8243; header_font=&#8221;||on||||||&#8221; header_text_color=&#8221;#00b2e2&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;|20px|30px||false|false&#8221; z_index_tablet=&#8221;500&#8243; border_width_bottom=&#8221;3px&#8221; border_color_bottom=&#8221;#8FD2ED&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><strong><u>Thank You to Our Sponsors<\/u><\/strong><\/p>\n<p>PRF\u2019s International Scientific Workshops are only possible through the generosity of committed partners who believe in the power of science to change lives.<\/p>\n<p>We are deeply grateful for the support of <a href=\"https:\/\/www.aiprosab.org\/en\/home-english\/\">The Associazione Italiana Progeria Sammy Basso<\/a>.<\/p>\n<p><em>Stay tuned for the 13th Annual PRF Scientific Workshop. 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Come join us and hit the streets for the City of Peabody\u2019s largest annual road race. 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And you can be ONE to make the cure POSSIBLE.<\/strong><\/p>\n<p>[\/et_pb_text][\/et_pb_column_inner][et_pb_column_inner type=&#8221;1_2&#8243; saved_specialty_column_type=&#8221;3_4&#8243; _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2026\/05\/group-resized-1280&#215;864-with-border.jpg&#8221; title_text=&#8221;group resized 1280&#215;864 with border&#8221; admin_label=&#8221;Fab 4 image&#8221; _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;20px|15px||0px|false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner custom_padding_last_edited=&#8221;on|desktop&#8221; padding_left_right_link_1=&#8221;true&#8221; padding_left_right_link_2=&#8221;true&#8221; _builder_version=&#8221;4.16&#8243; custom_margin=&#8221;7px|||||&#8221; 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button_bg_color=&#8221;#29327A&#8221; button_border_color=&#8221;#29327A&#8221; background_layout=&#8221;dark&#8221; custom_margin=&#8221;||20px||false|false&#8221; custom_padding=&#8221;||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_button][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||-41px|||&#8221; custom_padding=&#8221;4px|||||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column_inner saved_specialty_column_type=&#8221;3_4&#8243; _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;OP TEAMS&#8221; _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; header_text_color=&#8221;#FFFFFF&#8221; background_color=&#8221;#00B2E2&#8243; custom_padding=&#8221;10px|20px|||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2 style=\"text-align: center;\"><span style=\"color: #ffffff;\">Meet the 2026 ONEpossible Teams<\/span><\/h2>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner column_structure=&#8221;1_2,1_2&#8243; custom_padding_last_edited=&#8221;on|desktop&#8221; padding_left_right_link_1=&#8221;true&#8221; padding_left_right_link_2=&#8221;true&#8221; disabled_on=&#8221;off|off|off&#8221; _builder_version=&#8221;4.27.4&#8243; custom_margin=&#8221;|30px|||false|false&#8221; custom_padding_tablet=&#8221;0px|35px||35px&#8221; custom_padding_phone=&#8221;0px||0px&#8221; animation_direction=&#8221;right&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column_inner type=&#8221;1_2&#8243; saved_specialty_column_type=&#8221;3_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|20px||20px&#8221; custom_padding_tablet=&#8221;|0px||0px&#8221; custom_padding_phone=&#8221;||30px&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;TEAM FAB 4&#8243; _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;|20px||20px|false|false&#8221; custom_padding=&#8221;|20px||20px|false|false&#8221; link_option_url=&#8221;https:\/\/fundraise.givesmart.com\/vf\/Progeria\/team\/Zoey&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3 style=\"text-align: center;\"><strong><span style=\"color: #000080;\"><a href=\"https:\/\/fundraise.givesmart.com\/vf\/FINDTHECURE\/team\/TeamFabFour\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-21854 aligncenter size-large\" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2026\/05\/FAB4-1200X810with-border-1024x691.jpg\" alt=\"\" width=\"502\" height=\"339\" \/><\/a><a href=\"https:\/\/fundraise.givesmart.com\/vf\/FINDTHECURE\/team\/TeamFabFour\">TEAM FAB FOUR<\/a><\/span><\/strong><\/h3>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;TEAM ZOEY&#8221; _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;|20px||20px|false|false&#8221; custom_padding=&#8221;|20px||20px|false|false&#8221; link_option_url=&#8221;https:\/\/fundraise.givesmart.com\/vf\/Progeria\/team\/Zoey&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3 style=\"text-align: center;\"><strong><a href=\"https:\/\/fundraise.givesmart.com\/vf\/Progeria\/team\/Zoey\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-21857 aligncenter \" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2026\/05\/Zoey-John-OP-2026.jpg\" alt=\"\" width=\"400\" height=\"400\" \/><\/a><a href=\"https:\/\/fundraise.givesmart.com\/vf\/Progeria\/team\/Zoey\"><span style=\"color: #000080;\">TEAM ZOEY<\/span><\/a><\/strong><\/h3>\n<p>[\/et_pb_text][\/et_pb_column_inner][et_pb_column_inner type=&#8221;1_2&#8243; saved_specialty_column_type=&#8221;3_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|20px|30px|20px&#8221; custom_padding_tablet=&#8221;|0px||0px&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|desktop&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;TEAM N&#038;B&#8221; _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;|20px||20px|false|false&#8221; custom_padding=&#8221;|20px||20px|false|false&#8221; link_option_url=&#8221;https:\/\/fundraise.givesmart.com\/vf\/Progeria\/team\/Zoey&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3 style=\"text-align: center;\"><strong><a href=\"https:\/\/fundraise.givesmart.com\/vf\/FINDTHECURE\/team\/TeamNathanandBennett\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-21856 aligncenter \" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2026\/05\/NB-2026.jpg\" alt=\"\" width=\"400\" height=\"400\" \/><\/a><a href=\"https:\/\/fundraise.givesmart.com\/vf\/FINDTHECURE\/team\/TeamNathanandBennett\"><span style=\"color: #000080;\">TEAM NATHAN &amp; BENNETT<\/span><\/a><\/strong><\/h3>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;TEAM PRF&#8221; _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;|20px||20px|false|false&#8221; custom_padding=&#8221;|20px||20px|false|false&#8221; link_option_url=&#8221;https:\/\/fundraise.givesmart.com\/vf\/Progeria\/team\/PRF&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3 style=\"text-align: center;\"><strong><a href=\"https:\/\/fundraise.givesmart.com\/vf\/FINDTHECURE\/team\/TeamPRF\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-21861 aligncenter size-large\" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2026\/05\/LOGO-for-op2026-1024x552.jpg\" alt=\"\" width=\"501\" height=\"270\" \/><\/a><a href=\"https:\/\/fundraise.givesmart.com\/vf\/FINDTHECURE\/team\/TeamPRF\"><span style=\"color: #000080;\">TEAM PRF<\/span><\/a><\/strong><\/h3>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;4px|||||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column_inner saved_specialty_column_type=&#8221;3_4&#8243; _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;QUOTES&#8221; _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; header_text_color=&#8221;#FFFFFF&#8221; background_color=&#8221;#00B2E2&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2 style=\"text-align: center;\"><span style=\"color: #ffffff;\"><\/span><\/h2>\n<h2 style=\"text-align: center;\"><span style=\"color: #ffffff;\">Quotes from THE FAB FOUR!<\/span><\/h2>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner column_structure=&#8221;1_2,1_2&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; padding_left_right_link_1=&#8221;true&#8221; padding_left_right_link_2=&#8221;true&#8221; padding_left_right_link_3=&#8221;true&#8221; admin_label=&#8221;Row&#8221; _builder_version=&#8221;4.27.5&#8243; custom_margin=&#8221;15px||||false|false&#8221; custom_padding=&#8221;12px|30px|0||false|false&#8221; custom_padding_tablet=&#8221;|35px||35px||true&#8221; custom_padding_phone=&#8221;|35px||35px||true&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column_inner type=&#8221;1_2&#8243; saved_specialty_column_type=&#8221;3_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|10px||10px&#8221; custom_padding_tablet=&#8221;||40px&#8221; custom_padding_phone=&#8221;||30px&#8221; custom_padding_last_edited=&#8221;on|tablet&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_testimonial author=&#8221;Merlin 24-years-old&#8221; quote_icon_color=&#8221;#00B2E2&#8243; quote_icon_background_color=&#8221;#FFFFFF&#8221; admin_label=&#8221;Merlin quote&#8221; _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; body_text_color=&#8221;#29327A&#8221; author_text_color=&#8221;#29327A&#8221; custom_margin=&#8221;||16px||false|false&#8221; custom_padding=&#8221;30px||10px||false|false&#8221; border_radii=&#8221;on|15px|15px|15px|15px&#8221; box_shadow_style=&#8221;preset6&#8243; box_shadow_color=&#8221;#00B2E2&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><strong>I\u2019m an artist. I\u2019m a writer. I\u2019m an author. I\u2019m a cellist <\/strong><strong>and a musician. I earned my Bachelor of Fine Arts <\/strong><strong>degree in creative writing back in 2022. I have <\/strong><strong>published a children\u2019s book, and I have been part of <\/strong><strong>the Progeria research trials since 2002. I\u2019m immensely <\/strong><strong>grateful for the work that PRF has done to get us <\/strong><strong>this far in life. <\/strong><\/p>\n<p>[\/et_pb_testimonial][et_pb_testimonial author=&#8221;Michiel 27-years-old&#8221; quote_icon_color=&#8221;#00B2E2&#8243; quote_icon_background_color=&#8221;#FFFFFF&#8221; admin_label=&#8221;Michiel quote&#8221; _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; body_text_color=&#8221;#29327A&#8221; author_text_color=&#8221;#29327A&#8221; custom_padding=&#8221;||||false|false&#8221; border_radii=&#8221;on|15px|15px|15px|15px&#8221; box_shadow_style=&#8221;preset6&#8243; box_shadow_color=&#8221;#00B2E2&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><strong>I\u2019m 27 years old, which I\u2019m very happy to be because <\/strong><strong>since I was 5, they told me I wouldn\u2019t even get to 12 <\/strong><strong>years old. I\u2019m so happy to still be here today.<\/strong><\/p>\n<p>[\/et_pb_testimonial][\/et_pb_column_inner][et_pb_column_inner type=&#8221;1_2&#8243; saved_specialty_column_type=&#8221;3_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|10px||10px&#8221; custom_padding_tablet=&#8221;||40px&#8221; custom_padding_phone=&#8221;||30px&#8221; custom_padding_last_edited=&#8221;on|desktop&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_testimonial author=&#8221;Kaylee 22-years-old&#8221; quote_icon_color=&#8221;#00B2E2&#8243; quote_icon_background_color=&#8221;#FFFFFF&#8221; admin_label=&#8221;Kaylee quote&#8221; _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; body_text_color=&#8221;#29327A&#8221; author_text_color=&#8221;#29327A&#8221; custom_margin=&#8221;||20px||false|false&#8221; custom_padding=&#8221;||10px||false|false&#8221; border_radii=&#8221;on|15px|15px|15px|15px&#8221; box_shadow_style=&#8221;preset6&#8243; box_shadow_color=&#8221;#00B2E2&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><strong>Getting older, I definitely have more health struggles, <\/strong><strong>but the Progeria Research Foundation has helped me <\/strong><strong>every step of the way and has helped me to be able to <\/strong><strong>accomplish things like going to college and driving.<\/strong><\/p>\n<p>[\/et_pb_testimonial][et_pb_testimonial author=&#8221;Amber 19-years-old&#8221; quote_icon_color=&#8221;#00B2E2&#8243; quote_icon_background_color=&#8221;#FFFFFF&#8221; admin_label=&#8221;Amber quote&#8221; _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; body_text_color=&#8221;#29327A&#8221; author_text_color=&#8221;#29327A&#8221; border_radii=&#8221;on|15px|15px|15px|15px&#8221; box_shadow_style=&#8221;preset6&#8243; box_shadow_color=&#8221;#00B2E2&#8243; global_colors_info=&#8221;{}&#8221;]<strong>[My hope for the future is] to improve life and to get <\/strong><strong>us to live longer and hopefully, eventually, a cure, <\/strong><strong>which I\u2019m sure will happen. I\u2019m <\/strong><strong>really glad to be a part of something that can maybe <\/strong><strong>help future kids so they can have a cure.<\/strong> [\/et_pb_testimonial][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; module_class=&#8221;footer&#8221; _builder_version=&#8221;4.27.5&#8243; background_color=&#8221;#29327a&#8221; custom_margin=&#8221;-2px|||||&#8221; custom_padding=&#8221;0|0px|0|20px|false|false&#8221; z_index_tablet=&#8221;500&#8243; border_width_top=&#8221;12px&#8221; border_color_top=&#8221;#00b2e2&#8243; global_module=&#8221;133&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_4,1_4,1_2&#8243; make_equal=&#8221;on&#8221; module_class=&#8221; et_pb_row_fullwidth&#8221; _builder_version=&#8221;4.16&#8243; width=&#8221;89%&#8221; width_tablet=&#8221;80%&#8221; width_phone=&#8221;&#8221; width_last_edited=&#8221;on|desktop&#8221; max_width=&#8221;89%&#8221; 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_builder_version=&#8221;4.27.4&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;-74px|auto||auto|false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Pttc&#8221; _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-20802 aligncenter\" style=\"display: block; margin-left: auto; margin-right: auto;\" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2025\/08\/PTCP_wPRF-1024x511.jpg\" alt=\"\" width=\"491\" height=\"245\" \/><\/p>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;Sam-Pro 2&#8243; _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>PRF has entered into a manufacturing agreement with\u00a0<a href=\"https:\/\/www.forgebiologics.com\/\">Forge Biologics\u00a0<\/a>to produce\u00a0<strong>SamPro-2<\/strong> &#8211; PRF\u2019s investigational gene-editing therapy designed to correct the gene mutation that causes Progeria.<\/p>\n<p>This is a defining step toward Progeria gene therapy clinical trials.<\/p>\n<h4><strong>What is SamPro-2?<\/strong><\/h4>\n<p><strong><\/strong>SamPro-2 is PRF\u2019s gene editing therapy designed to correct the single DNA letter misspelling that causes Progeria.<\/p>\n<p>DNA is the body\u2019s instruction manual. In children and young adults with Progeria, one single letter in that manual is wrong \u2013 there is a \u201cT\u201d that should be a \u201cC\u201d. That single-letter change leads to the production of a toxic protein called progerin that causes the disease.<\/p>\n<p>SamPro-2 is built to correct that error \u2014 permanently changing the \u201cT\u201d back to a \u201cC\u201d \u2014 with the goal of stopping the disease inside the body\u2019s cells at its source.<\/p>\n<p>[\/et_pb_text][et_pb_testimonial quote_icon_color=&#8221;#FFFFFF&#8221; quote_icon_background_color=&#8221;#8FD2ED&#8221; admin_label=&#8221;Leslie Quote&#8221; _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; max_width=&#8221;65%&#8221; module_alignment=&#8221;center&#8221; min_height=&#8221;83px&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;1px||12px||false|false&#8221; border_radii=&#8221;on|35px|35px|35px|35px&#8221; border_width_all=&#8221;5px&#8221; border_color_all=&#8221;#00B2E2&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>&nbsp;<\/p>\n<p>\u201c<em>The era of Progeria gene therapy has arrived. Our hope is that SamPro-2 will give children and young adults with Progeria the longer, healthier lives they deserve. We are extremely grateful to be working with Forge Biologics, whose manufacturing expertise is essential to move this work from the laboratory towards clinical trials<\/em>.\u201d<\/p>\n<p>~Leslie Gordon, M.D., Ph.D., co-founder and medical director of PRF and the mother of Sam Berns who had Progeria<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-28 aligncenter \" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/PRF_Logo_2019_4color.png\" alt=\"\" width=\"333\" height=\"95\" srcset=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/PRF_Logo_2019_4color.png 595w, https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/PRF_Logo_2019_4color-300x86.png 300w\" sizes=\"(max-width: 333px) 100vw, 333px\" \/><\/p>\n<p>\u200b<\/p>\n<p>[\/et_pb_testimonial][et_pb_text admin_label=&#8221;PRF chose Forge&#8221; _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4><strong>Why PRF Chose Forge to Manufacture SamPro-2<\/strong><\/h4>\n<p>Before any gene therapy can be given to a person, it must be:<\/p>\n<ul>\n<li>Manufactured in highly specialized, ultra-clean facilities<\/li>\n<li>Produced under strict current Good Manufacturing Practice (cGMP) standards<\/li>\n<li>Tested repeatedly for safety, purity, and consistency<\/li>\n<li>Prepared for U.S. FDA regulatory review<\/li>\n<\/ul>\n<p>Forge Biologics is a leader in gene therapy manufacturing. Their expertise will help us move SamPro-2 from breakthrough laboratory science to clinical trials for children and young adults with Progeria.<\/p>\n<p>Manufacturing is the bridge between discovery and treatment.<\/p>\n<p>This partnership builds that bridge.<\/p>\n<p>[\/et_pb_text][et_pb_testimonial quote_icon_color=&#8221;#FFFFFF&#8221; quote_icon_background_color=&#8221;#8FD2ED&#8221; admin_label=&#8221;Forge Quote&#8221; _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; max_width=&#8221;65%&#8221; module_alignment=&#8221;center&#8221; min_height=&#8221;83px&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;1px||12px||false|false&#8221; border_radii=&#8221;on|35px|35px|35px|35px&#8221; border_width_all=&#8221;5px&#8221; border_color_all=&#8221;#00B2E2&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>&nbsp;<\/p>\n<p>\u201c<em>Behind every program like this are patients and families who have waited a long time for progress. The Progeria Research Foundation and its Gene Team have shown extraordinary dedication to advancing this science, and we are honored to partner with them. At Forge, we bring that same level of care, expertise, and technical rigor to our manufacturing work as we help advance this program for patients.\u201d<\/em><\/p>\n<p>~John Maslowski, president and chief executive officer of Forge Biologics<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-21424 aligncenter \" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2026\/03\/Forge-Logo-1024x511.png\" alt=\"\" width=\"271\" height=\"135\" \/><\/p>\n<p>\u200b<\/p>\n<p>[\/et_pb_testimonial][et_pb_text admin_label=&#8221;Progeria Gene Dream Team&#8221; _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4><strong>The Progeria Gene Team<\/strong><\/h4>\n<p>PRF and its collaborators, collectively known as the Progeria Gene Team, created SamPro-2. The Progeria Gene Team brings together internationally recognized leaders in genetics, clinical medicine, and biomedical innovation, all driven by a shared commitment to finding the cure for Progeria.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-21425 aligncenter \" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2026\/03\/GeneTeamforge-page-1024x414.jpg\" alt=\"\" width=\"734\" height=\"297\" \/><\/p>\n<p><strong>Francis S. Collins, MD, PhD<\/strong><br \/>Senior Research Advisor to PRF and former Director of the National Institutes of Health, who led the Human Genome Project \u2014 one of the most significant scientific achievements of our time \u2014 and helped usher genetics into the modern era.<\/p>\n<p><strong>Leslie Gordon, MD, PhD<\/strong><br \/>PRF Co-founder and Medical Director; the world\u2019s leading expert on Progeria and a driving force behind every major breakthrough in the field. Dr. Gordon is also the mother of Sam, whose life inspired PRF\u2019s creation and continues to fuel its urgency.<\/p>\n<p><strong>David R. Liu, PhD<\/strong><br \/>Richard Merkin Professor and Director of the Merkin Institute for Transformative Technologies in Healthcare at the Broad Institute of MIT and Harvard. Dr. Liu is a globally recognized pioneer in gene editing and an international leader in the development of base editing technologies that are reshaping modern medicine.<\/p>\n<p><strong>The late Sammy Basso, MS<\/strong><br \/>Scientist, advocate, and extraordinary member of the global Progeria community. Sammy\u2019s intellect, courage, and unwavering commitment to advancing research continue to inspire and guide this work.\u00a0 Sammy was PRF\u2019s international ambassador. Sammy and his family created Associazione Italiana Progeria Sammy Basso\u00a0(A.I.Pro.Sa.B.) to help find the cure for Progeria.<\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;why turning point&#8221; _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4><strong>Why This Is a Turning Point<\/strong><\/h4>\n<p>For families, this is tangible momentum.<\/p>\n<p>For donors, this is the impact of your investment in bold science.<\/p>\n<p>For the broader rare disease community, this represents one of the most advanced efforts yet to correct a fatal, pediatric, multi-system disease at its genetic source.<\/p>\n<p>We still have important work ahead. But this is a big step forward. And every step brings us closer to our vision: <strong>A world where every child with Progeria is cured.<\/strong><\/p>\n<p><a href=\"https:\/\/www.progeriaresearch.org\/press-room\/\"><strong>Read the Press Release Here<\/strong><\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>PRF \u05de\u05db\u05e8\u05d9\u05d6\u05d4 \u05e2\u05dc \u05e9\u05d5\u05ea\u05e4\u05d5\u05ea \u05d9\u05d9\u05e6\u05d5\u05e8 \u05e2\u05dd Forge Biologics \u05dc\u05e7\u05d9\u05d3\u05d5\u05dd \u05d8\u05d9\u05e4\u05d5\u05dc \u05d2\u05e0\u05d8\u05d9 \u05d1\u05e4\u05e8\u05d5\u05d2\u05e8\u05d9\u05d4!<br \/>\n\u05d4\u05db\u05e8\u05d6\u05d4 \u05d6\u05d5 \u05de\u05e1\u05de\u05e0\u05ea \u05d0\u05d1\u05df \u05d3\u05e8\u05da \u05de\u05e9\u05de\u05e2\u05d5\u05ea\u05d9\u05ea: PRF \u05d7\u05ea\u05de\u05d4 \u05e2\u05dc \u05d4\u05e1\u05db\u05dd \u05d9\u05d9\u05e6\u05d5\u05e8 \u05e2\u05dd Forge Biologics \u05dc\u05d9\u05d9\u05e6\u05d5\u05e8 SamPro-2, \u05d8\u05d9\u05e4\u05d5\u05dc \u05e2\u05e8\u05d9\u05db\u05ea \u05d2\u05e0\u05d9\u05dd \u05e9\u05dc\u05d4 \u05d4\u05e0\u05de\u05e6\u05d0 \u05d1\u05e4\u05d9\u05ea\u05d5\u05d7 \u05e2\u05d1\u05d5\u05e8 \u05d9\u05dc\u05d3\u05d9\u05dd \u05d5\u05de\u05d1\u05d5\u05d2\u05e8\u05d9\u05dd \u05e6\u05e2\u05d9\u05e8\u05d9\u05dd \u05e2\u05dd \u05e4\u05e8\u05d5\u05d2&#039;\u05e8\u05d9\u05d4 - \u05e6\u05e2\u05d3 \u05d7\u05d9\u05d5\u05e0\u05d9 \u05dc\u05e7\u05e8\u05d0\u05ea \u05e0\u05d9\u05e1\u05d5\u05d9\u05d9\u05dd \u05e7\u05dc\u05d9\u05e0\u05d9\u05d9\u05dd, \u05d5\u05d1\u05e1\u05d5\u05e4\u05d5 \u05e9\u05dc \u05d3\u05d1\u05e8, \u05e8\u05d9\u05e4\u05d5\u05d9! <\/p>","protected":false},"author":2,"featured_media":21431,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[11,2,1],"tags":[],"class_list":["post-21417","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-homepage-news","category-news","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>PRF Partnership with Forge I The Progeria Research Foundation<\/title>\n<meta name=\"description\" content=\"PRF Announces Manufacturing Partnership with Forge Biologics to Advance Progeria Gene Therapy! This announcement marks a major milestone: PRF has entered into a manufacturing agreement with Forge Biologics to produce SamPro-2, its gene editing therapy in development for children and young adults with Progeria -- an essential step toward clinical trials and, ultimately, the cure!\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.progeriaresearch.org\/he\/2026\/03\/03\/prfandforge\/\" \/>\n<meta property=\"og:locale\" content=\"he_IL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PRF Partnership with Forge I The Progeria Research Foundation\" \/>\n<meta property=\"og:description\" content=\"PRF Announces Manufacturing Partnership with Forge Biologics to Advance Progeria Gene Therapy! 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\u05d0\u05ea \u05d4\u05e0\u05d9\u05d5\u05d6\u05dc\u05d8\u05e8 \u05e9\u05dc PRF \u05dc\u05e9\u05e0\u05ea 2025 \u05db\u05d0\u05df!"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;4px|||||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_3,2_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2025\/09\/2025-newsletter-image.jpg&#8221; title_text=&#8221;2025 newsletter image&#8221; admin_label=&#8221;2025 Newsletter&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||7px|||&#8221; custom_padding=&#8221;||3px|||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3 class=\"p1\">Collaboration = Progress<\/h3>\n<p class=\"p1\">The Progerinin trial is a partnership between PRF, trial sponsor PRG Science &amp; Technology (a Korean- based biotech company), Boston Children\u2019s Hospital (the trial site), Brigham and Women\u2019s Hospital (site for some trial tests), and of course the families who are with us every step of the way!<\/p>\n<p style=\"font-weight: 400;\">Inside, you\u2019ll get:<\/p>\n<ul>\n<li style=\"font-weight: 400;\">\n<p class=\"p1\">Research Updates: Progerinin Clinical Trial is Well Underway! Gene Therapy: PRF\u2019s Path to CURE PROGERIA is Big News!<\/p>\n<\/li>\n<li style=\"font-weight: 400;\">PRF On The Move! The China Rare Disease Summit in China, The Center for Research in Molecular Medicine and Chronic Diseases (CiMUS) in Spain, The 5th International Meeting on Laminopathies<span class=\"s1\"> in <\/span>France and dozens of business and research leaders at major US conferences.<\/li>\n<li style=\"font-weight: 400;\">\n<p class=\"p1\">FUNdraising Events &#8211; Fun Times, Fabulous People!<\/p>\n<\/li>\n<li>\n<p class=\"p1\">PRF 2024 Annual Report<\/p>\n<\/li>\n<\/ul>\n<p>[\/et_pb_text][et_pb_button button_url=&#8221;https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2025\/09\/18219-2025-FALL-NEWSLETTER_final.pdf&#8221; url_new_window=&#8221;on&#8221; button_text=&#8221;Click here to View as PDF&#8221; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;pdf&#8221; _builder_version=&#8221;4.27.4&#8243; background_layout=&#8221;dark&#8221; custom_margin=&#8221;30px||||false|false&#8221; z_index_tablet=&#8221;500&#8243; global_colors_info=&#8221;{}&#8221;][\/et_pb_button][et_pb_text disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Shortcode&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<a class=\"_df_thumb \"  href=\"#\"  data-slug=\"21065\" data-_slug=\"21065\" _slug=\"21065\" data-title=\"2025-prf-newsletter\" id=\"df_21065\" data-df-option=\"df_option_21065\" thumb=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2025\/09\/Screenshot-2025-09-25-at-9.01.34-AM.png\"  >2025 PRF Newsletter<\/a><script class=\"df-shortcode-script\" nowprocket type=\"application\/javascript\">window.df_option_21065 = {\"source\":\"https:\\\/\\\/www.progeriaresearch.org\\\/wp-content\\\/uploads\\\/2025\\\/09\\\/18219-2025-FALL-NEWSLETTER_final.pdf\",\"outline\":[],\"overwritePDFOutline\":false,\"pageSize\":\"0\",\"slug\":\"21065\",\"wpOptions\":\"true\",\"id\":21065}; if(window.DFLIP && window.DFLIP.parseBooks){window.DFLIP.parseBooks();}<\/script>\n<p>[\/et_pb_text][et_pb_button button_url=&#8221;https:\/\/www.progeriaresearch.org\/?form=donate&#8221; button_text=&#8221;Donate Here&#8221; admin_label=&#8221;Button \u2013 Donate&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; button_text_color=&#8221;#FFFFFF&#8221; button_bg_color=&#8221;#00B2E2&#8243; button_border_color=&#8221;#00B2E2&#8243; background_layout=&#8221;dark&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p><b>\u05d8\u05e8\u05d9 \u05de\u05d4\u05d3\u05e4\u05d5\u05e1: \u05d4\u05e0\u05d9\u05d5\u05d6\u05dc\u05d8\u05e8 \u05e9\u05dc PRF \u05dc\u05e9\u05e0\u05ea 2025!<\/b> \u05e7\u05d1\u05dc\u05d5 \u05d0\u05ea \u05d4\u05e2\u05d3\u05db\u05d5\u05e0\u05d9\u05dd \u05d4\u05d0\u05d7\u05e8\u05d5\u05e0\u05d9\u05dd \u05e2\u05dc \u05d4\u05e0\u05d9\u05e1\u05d5\u05d9 \u05d4\u05e7\u05dc\u05d9\u05e0\u05d9 \u05e9\u05dc \u05e4\u05e8\u05d5\u05d2\u05e8\u05d9\u05e0\u05d9\u05df, \u05d4\u05d3\u05e8\u05da \u05e9\u05dc\u05e0\u05d5 \u05dc\u05e8\u05d9\u05e4\u05d5\u05d9 \u05e4\u05e8\u05d5\u05d2\u05e8\u05d9\u05d4, \u05d5\u05e2\u05d5\u05d3 \u05d4\u05e8\u05d1\u05d4 \u05d9\u05d5\u05ea\u05e8!<\/p>","protected":false},"author":2,"featured_media":21093,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[11,2,1],"tags":[],"class_list":["post-21057","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-homepage-news","category-news","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Newsletter 2025 | The Progeria Research Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.progeriaresearch.org\/he\/2025\/09\/25\/prfnewsletter2025\/\" \/>\n<meta property=\"og:locale\" content=\"he_IL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Newsletter 2025 | The Progeria Research Foundation\" \/>\n<meta property=\"og:description\" content=\"Hot off the press: PRF\u2019s 2025 Newsletter! 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\u05d9\u05d5\u05e8\u05e7\u05e8 \u05de\u05e4\u05e8\u05e1\u05dd \u05e2\u05e8\u05d9\u05db\u05ea \u05d2\u05e0\u05d9\u05dd \u05e9\u05dc \u05e4\u05e8\u05d5\u05d2\u05e8\u05d9\u05d4: PRF \u05d1\u05d3\u05e8\u05da \u05dc\u05e8\u05d9\u05e4\u05d5\u05d9 \u05e4\u05e8\u05d5\u05d2\u05e8\u05d9\u05d4!"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.27.4&#8243; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_row _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;-74px|auto||auto|false|false&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_text admin_label=&#8221;Path &#038; Alptug images&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;]<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-20802  aligncenter\" style=\"display: block; margin-left: auto; margin-right: auto;\" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2025\/08\/PTCP_wPRF-1024x511.jpg\" alt=\"\" width=\"491\" height=\"245\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-20805  aligncenter\" style=\"display: block; margin-left: auto; margin-right: auto;\" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2025\/08\/Alptug-in-frame-1-1024x768.jpg\" alt=\"\" width=\"390\" height=\"293\" \/><\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;]<\/p>\n<p style=\"font-weight: 400;\">As described in the August 11, 2025, front-page New Yorker article**, entitled <em>How an Ultra-Rare Disease Accelerates Aging,\u00a0<\/em>\u00a0The Progeria Research Foundation is thrilled to announce the pioneering\u00a0Progeria\u00a0<strong>Gene Editing Program.<\/strong>\u00a0<\/p>\n<p style=\"font-weight: 400;\">**<a href=\"https:\/\/www.newyorker.com\/magazine\/2025\/08\/18\/how-an-ultra-rare-disease-accelerates-aging\"><strong>Click here<\/strong><\/a> to read the full article.<\/p>\n<p>[\/et_pb_text][et_pb_testimonial quote_icon_color=&#8221;#FFFFFF&#8221; quote_icon_background_color=&#8221;#8FD2ED&#8221; admin_label=&#8221;KayleeQuote&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; min_height=&#8221;83px&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;1px||12px||false|false&#8221; hover_enabled=&#8221;0&#8243; border_radii=&#8221;on|35px|35px|35px|35px&#8221; border_width_all=&#8221;2px&#8221; border_color_all=&#8221;#00B2E2&#8243; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p>&nbsp;<\/p>\n<p><strong>&#8220;I\u2019ve been involved with PRF most of my life\u201d, says 22-year-old Kaylee from Ohio, who is prominently featured in the New Yorker article. \u201cI\u2019m really excited about the gene therapy they\u2019re working on!\u201d<\/strong><\/p>\n<p>[\/et_pb_testimonial][et_pb_text admin_label=&#8221;Kaylee image and Base editing text&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;]<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-20858 aligncenter \" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2025\/08\/MEKayleedog-2025-copy.jpg\" alt=\"\" width=\"341\" height=\"348\" \/><\/p>\n<p><strong>Base editing therapy<\/strong>\u00a0uses CRISPR technology to target and correct a specific DNA base (or &#8220;letter&#8221;) in the genetic code. <strong>Because Progeria is caused by a change to a single letter in the DNA, it is perfectly suited for this type of gene therapy.<\/strong><\/p>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;Progeria Gene Dream Team&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;]<\/p>\n<h4><span style=\"color: #3366ff;\"><strong>The Progeria Gene Team <\/strong><\/span><\/h4>\n<p>PRF has been collaborating with an extraordinary team of world-renowned scientists and innovators. The team\u2019s tireless work and dedication is bringing this transformative therapy to reality:<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-20844  aligncenter\" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2025\/08\/Gene-Team-.jpg\" alt=\"\" width=\"859\" height=\"346\" srcset=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2025\/08\/Gene-Team-.jpg 859w, https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2025\/08\/Gene-Team--480x193.jpg 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) 859px, 100vw\" \/>Top Left to Bottom Right:<br \/><strong>Francis Collins, MD, PhD<\/strong>\u00a0\u2013 Longtime Progeria research partner and former Director of the National Institutes of Health (NIH)<br \/><strong>Michael Erdos, PhD<\/strong>\u00a0\u2013 Associate Investigator, Molecular Genetics Section, National Human Genome Research Institute (NHGRI)<br \/><strong>Leslie Gordon, MD, PhD<\/strong>\u00a0\u2013 Co-founder &amp; Medical Director of PRF, and the world\u2019s foremost expert on Progeria<br \/><strong>David Liu, PhD<\/strong>\u00a0\u2013 MIT\u2019s Broad Institute and Harvard University scientist, founder of\u00a0<strong>Base Editing<\/strong><strong>\u00a0<\/strong>Gene Therapy Technology<br \/>*<a href=\"https:\/\/www.progeriaresearch.org\/2024\/10\/09\/mourning-the-loss-of-prf-ambassador-sammy-basso\/\"><strong>Sammy Basso<\/strong><\/a>, MS, Co-Founder of The Associazione Italiana Progeria Sammy Basso and PRF Ambassador, was an integral part of this team until his passing in October 2024.<\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;Mouse Model&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;]<\/p>\n<h4><span style=\"color: #3366ff;\"><strong>From Mouse Model to Clinical Trials<\/strong><\/span><\/h4>\n<p>The\u00a0Progeria Gene Team\u00a0and their lab members first demonstrated that gene editing could <strong>dramatically increase the lifespan<\/strong> of the Progeria mouse model \u2014 by an astounding\u00a0<strong>140%<\/strong>\u00a0\u2014 a discovery that was published in one of the world\u2019s top scientific journals,\u00a0<a href=\"https:\/\/www.progeriaresearch.org\/2021\/01\/06\/kicking-off-the-new-year-with-exciting-research-news\/\"><strong><em>Nature<\/em><\/strong><\/a>. Building on this remarkable achievement, the team has refined the drug and is now focused on steps needed to start a clinical trial: drug manufacturing, engaging with the US FDA, and developing clinical trial protocols.<\/p>\n<p>The journey ahead will be multi-stage, technically complicated, and expensive. <strong>PRF is determined to meet every challenge to bring gene therapy to children and young adults with Progeria.<\/strong><\/p>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;Community-Driven Mission&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;]<\/p>\n<h4><span style=\"color: #3366ff;\"><strong>A Community-Driven Mission<\/strong><\/span><\/h4>\n<p><strong>The Progeria Community has been with us every step of the way.<\/strong> PRF\u2019s leadership team regularly hosts online meetings with Progeria families throughout the world, so they are our partners on this journey toward the cure.<\/p>\n<p>Moreover, the implications of this work may extend far beyond Progeria. <strong>In addition to curing Progeria, we are forging a path that other rare diseases can follow. <\/strong>Thus, this could be a groundbreaking leap forward not only for Progeria, but for other conditions that have long been overlooked.<i><\/i><\/p>\n<p>[\/et_pb_text][et_pb_testimonial quote_icon_color=&#8221;#FFFFFF&#8221; quote_icon_background_color=&#8221;#8FD2ED&#8221; admin_label=&#8221;Liu Quote&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; min_height=&#8221;83px&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;1px||12px||false|false&#8221; border_radii=&#8221;on|35px|35px|35px|35px&#8221; border_width_all=&#8221;2px&#8221; border_color_all=&#8221;#00B2E2&#8243; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;]<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u201cThe hope of our team is to use base editing to fix the root cause of progeria, providing a pathway to a potential cure for children with progeria, as well as advancing treatments for millions of other children with fatal genetic diseases.\u201d<\/strong><\/p>\n<p>[\/et_pb_testimonial][et_pb_text admin_label=&#8221;Liu &#038; Sammy B&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;]<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-20859 aligncenter \" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2025\/08\/David-Lui-Sammy-Basso.jpg\" alt=\"\" width=\"400\" height=\"336\" \/><strong>David Liu,\u00a0<a title=\"https:\/\/www.youtube.com\/watch?v=IMpczE6WDzQ\" href=\"https:\/\/www.youtube.com\/watch?v=IMpczE6WDzQ\" data-outlook-id=\"1a2d9f3a-689d-4ed7-b6a7-79154ecb3e35\">2025 Breakthrough Prize Laureate in the Life Sciences<\/a> for the development of base editing and prime editing, with Sammy Basso at the Brilliant Minds Conference in Sweden in 2023. They received a standing ovation for their presentation on base editing and progeria.<\/strong><br \/><i><\/i><\/p>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;Your Support is Vital&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;8px|||||&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;]<\/p>\n<h4><span style=\"color: #3366ff;\"><strong>Your Support is Vital <\/strong><\/span><\/h4>\n<p>Gene therapy is the most promising and the most expensive type of drug to manufacture. <strong>The unwavering commitment of PRF\u2019s passionate supporters like you will make Progeria gene editing a reality.<\/strong><\/p>\n<p>&nbsp;<\/p>\n<h3><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-20807  alignright\" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2025\/08\/Amina-handsin-frame-979x1024.jpg\" alt=\"\" width=\"291\" height=\"304\" \/><\/h3>\n<h3><\/h3>\n<h4 style=\"text-align: center;\"><strong>Together, we are on the verge of something extraordinary. <\/strong><\/h4>\n<h4 style=\"text-align: center;\"><\/h4>\n<h4 style=\"text-align: center;\"><\/h4>\n<h4 style=\"text-align: center;\"><span style=\"color: #3366ff;\"><strong><\/strong><\/span><\/h4>\n<h4 style=\"text-align: center;\"><span style=\"color: #3366ff;\"><strong>Together, we <em>WILL<\/em> find the cure!<\/strong><\/span><\/h4>\n<p>[\/et_pb_text][et_pb_button button_url=&#8221;https:\/\/www.progeriaresearch.org\/2025\/05\/27\/rdd-2025-cimus\/?form=donate&#8221; button_text=&#8221;Donate to Fund Progeria Gene Therapy!&#8221; button_alignment=&#8221;center&#8221; admin_label=&#8221;Donate button&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; button_text_color=&#8221;#FFFFFF&#8221; button_bg_color=&#8221;#00B2E2&#8243; button_border_color=&#8221;#00B2E2&#8243; background_layout=&#8221;dark&#8221; custom_margin=&#8221;50px||||false|false&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u05d1-11 \u05d1\u05d0\u05d5\u05d2\u05d5\u05e1\u05d8 2025, \u05e4\u05e8\u05e1\u05d5\u05dd \u05d9\u05d5\u05e7\u05e8\u05ea\u05d9 \u05d6\u05d4 \u05d4\u05e6\u05d9\u05d2 \u05de\u05d0\u05de\u05e8 \u05de\u05e2\u05de\u05d9\u05e7 \u05d4\u05de\u05e4\u05e8\u05d8 \u05d0\u05ea \u05d4\u05d4\u05d9\u05e1\u05d8\u05d5\u05e8\u05d9\u05d4 \u05e9\u05dc PRF, \u05d4\u05d9\u05e9\u05d2\u05d9\u05d4 \u05d5\u05d4\u05d4\u05ea\u05de\u05e7\u05d3\u05d5\u05ea \u05d4\u05e0\u05d5\u05db\u05d7\u05d9\u05ea \u05e9\u05dc\u05d4 \u05d1\u05d8\u05d9\u05e4\u05d5\u05dc \u05d2\u05e0\u05d8\u05d9 \u05e9\u05d9\u05db\u05d5\u05dc \u05dc\u05e7\u05e8\u05d1 \u05d0\u05d5\u05ea\u05e0\u05d5 \u05dc\u05e8\u05d9\u05e4\u05d5\u05d9 \u05e9\u05dc \u05e4\u05e8\u05d5\u05d2\u05e8\u05d9\u05d4. \u05d4\u05de\u05e1\u05e2 \u05d9\u05d5\u05e6\u05d0 \u05d4\u05d3\u05d5\u05e4\u05df \u05e9\u05dc\u05e0\u05d5 \u05de\u05d2\u05d9\u05e2 \u05dc\u05de\u05d9\u05dc\u05d9\u05d5\u05e0\u05d9\u05dd \u05e0\u05d5\u05e1\u05e4\u05d9\u05dd \u05d1\u05e8\u05d7\u05d1\u05d9 \u05d4\u05e2\u05d5\u05dc\u05dd!<\/p>","protected":false},"author":2,"featured_media":20856,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[11,2,1],"tags":[],"class_list":["post-20799","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-homepage-news","category-news","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Gene Editing: PRF I The Progeria Research Foundation<\/title>\n<meta name=\"description\" content=\"On August 11, 2025, this top-tier publication featured an in-depth article detailing PRF\u2019s history, accomplishments, and present focus on the Gene Therapy that could bring us closer to curing Progeria. Our extraordinary journey is reaching millions more throughout the world!\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.progeriaresearch.org\/he\/2025\/08\/08\/gene-editing\/\" \/>\n<meta property=\"og:locale\" content=\"he_IL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gene Editing: PRF I The Progeria Research Foundation\" \/>\n<meta property=\"og:description\" content=\"On August 11, 2025, this top-tier publication featured an in-depth article detailing PRF\u2019s history, accomplishments, and present focus on the Gene Therapy that could bring us closer to curing Progeria. Our extraordinary journey is reaching millions more throughout the world!\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.progeriaresearch.org\/he\/2025\/08\/08\/gene-editing\/\" \/>\n<meta property=\"og:site_name\" content=\"The Progeria Research Foundation\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ProgeriaResearch\/\" \/>\n<meta property=\"article:published_time\" content=\"2025-08-08T14:11:20+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-01-13T18:38:13+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2025\/08\/New-yorker-featured-image.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1000\" \/>\n\t<meta property=\"og:image:height\" content=\"1000\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Karen Betournay\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@Progeria\" \/>\n<meta name=\"twitter:site\" content=\"@Progeria\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Karen Betournay\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 \u05d3\u05e7\u05d5\u05ea\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.progeriaresearch.org\\\/ta\\\/2025\\\/08\\\/08\\\/gene-editing\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.progeriaresearch.org\\\/ta\\\/2025\\\/08\\\/08\\\/gene-editing\\\/\"},\"author\":{\"name\":\"Karen Betournay\",\"@id\":\"https:\\\/\\\/www.progeriaresearch.org\\\/ta\\\/#\\\/schema\\\/person\\\/2be6cec85c11aaef7a7602636c5b9946\"},\"headline\":\"New Yorker Features Progeria Gene Editing: PRF is on the Path to CURE PROGERIA!\",\"datePublished\":\"2025-08-08T14:11:20+00:00\",\"dateModified\":\"2026-01-13T18:38:13+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.progeriaresearch.org\\\/ta\\\/2025\\\/08\\\/08\\\/gene-editing\\\/\"},\"wordCount\":1056,\"publisher\":{\"@id\":\"https:\\\/\\\/www.progeriaresearch.org\\\/ta\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.progeriaresearch.org\\\/ta\\\/2025\\\/08\\\/08\\\/gene-editing\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.progeriaresearch.org\\\/wp-content\\\/uploads\\\/2025\\\/08\\\/New-yorker-featured-image.jpg\",\"articleSection\":[\"Homepage News\",\"News\",\"Uncategorized\"],\"inLanguage\":\"he-IL\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.progeriaresearch.org\\\/ta\\\/2025\\\/08\\\/08\\\/gene-editing\\\/\",\"url\":\"https:\\\/\\\/www.progeriaresearch.org\\\/ta\\\/2025\\\/08\\\/08\\\/gene-editing\\\/\",\"name\":\"Gene Editing: PRF I The Progeria Research Foundation\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.progeriaresearch.org\\\/ta\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.progeriaresearch.org\\\/ta\\\/2025\\\/08\\\/08\\\/gene-editing\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.progeriaresearch.org\\\/ta\\\/2025\\\/08\\\/08\\\/gene-editing\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.progeriaresearch.org\\\/wp-content\\\/uploads\\\/2025\\\/08\\\/New-yorker-featured-image.jpg\",\"datePublished\":\"2025-08-08T14:11:20+00:00\",\"dateModified\":\"2026-01-13T18:38:13+00:00\",\"description\":\"On August 11, 2025, this top-tier publication featured an in-depth article detailing PRF\u2019s history, accomplishments, and present focus on the Gene Therapy that could bring us closer to curing Progeria. 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This groundbreaking trial will explore whether Progerinin, combined with the life-extending drug lonafarnib (Zokinvy), is more effective than lonafarnib alone.\u00a0<\/div>\n<div class=\"elementToProof\">\u00a0<\/div>\n<div class=\"elementToProof\">For more information, <a href=\"https:\/\/www.progeriaresearch.org\/2024\/09\/30\/newdrugtrial\/\">click here <\/a>and check back often for updates!\u00a0<\/div>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>PRF \u05e0\u05e8\u05d2\u05e9 \u05dc\u05d4\u05d5\u05d3\u05d9\u05e2 \u05e9\u05d4\u05d1\u05d9\u05e7\u05d5\u05e8\u05d9\u05dd \u05d4\u05e8\u05d0\u05e9\u05d5\u05e0\u05d9\u05dd \u05e9\u05dc \u05d4\u05de\u05d8\u05d5\u05e4\u05dc\u05d9\u05dd \u05d1\u05e0\u05d9\u05e1\u05d5\u05d9 \u05e7\u05dc\u05d9\u05e0\u05d9 \u05e4\u05e8\u05d5\u05d2\u05e8\u05d9\u05e0\u05d9\u05df \u05d4\u05e1\u05ea\u05d9\u05d9\u05de\u05d5! 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global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_row_inner _builder_version=&#8221;4.16&#8243; background_color=&#8221;#00b2e2&#8243; custom_margin=&#8221;41px||&#8221; custom_margin_tablet=&#8221;0px||&#8221; custom_margin_phone=&#8221;&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; custom_padding=&#8221;39.4375px|61px|0|61px|false|true&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;top&#8221; animation_intensity_slide=&#8221;25%&#8221; box_shadow_style=&#8221;preset1&#8243; box_shadow_blur=&#8221;38px&#8221; box_shadow_spread=&#8221;-12px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column_inner saved_specialty_column_type=&#8221;3_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;PARALLEL JOURNEYS&#8221; _builder_version=&#8221;4.27.4&#8243; text_font=&#8221;||||||||&#8221; header_font=&#8221;||||||||&#8221; header_2_font=&#8221;||||||||&#8221; header_2_line_height=&#8221;1.2em&#8221; header_3_font=&#8221;||||||||&#8221; header_4_font=&#8221;||||||||&#8221; background_layout=&#8221;dark&#8221; custom_margin=&#8221;||35px|-6px|false|false&#8221; custom_padding=&#8221;|0px|||false|false&#8221; custom_padding_tablet=&#8221;|50px||50px||true&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|desktop&#8221; header_font_size_tablet=&#8221;&#8221; header_font_size_phone=&#8221;&#8221; header_font_size_last_edited=&#8221;on|desktop&#8221; header_2_font_size_tablet=&#8221;25px&#8221; header_2_font_size_phone=&#8221;25px&#8221; header_2_font_size_last_edited=&#8221;on|tablet&#8221; header_4_font_size_tablet=&#8221;&#8221; header_4_font_size_phone=&#8221;19px&#8221; header_4_font_size_last_edited=&#8221;on|phone&#8221; header_4_line_height_tablet=&#8221;&#8221; header_4_line_height_phone=&#8221;1.2em&#8221; header_4_line_height_last_edited=&#8221;on|phone&#8221; z_index_tablet=&#8221;500&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2 class=\"p1\"><strong><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2025\/05\/LindsaycircleOP2025.png\" width=\"274\" height=\"274\" alt=\"\" class=\"wp-image-20562 alignleft size-full\" \/>PARALLEL JOURNEYS<\/strong><\/h2>\n<p class=\"p2\">Thanks to the FDA-approved treatment lonafarnib, those with Progeria are living longer and healthier lives, while PRF explores other drugs and genetic therapies that may help even more. They are traveling the world, attending college, and planning their futures \u2013 a reflection of how far we&#8217;ve come together in the fight against Progeria.<\/p>\n<p class=\"p2\">We are excited to feature one such young adult whose qualities mirror the story of The Progeria Research Foundation itself. Driven by determination and focus, Lindsay\u2019s and PRF\u2019s journeys are filled with extraordinary accomplishments and hope for the future &#8211; <strong>powerful reminders of the life-changing impact your support makes POSSIBLE.<\/strong><\/p>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner custom_padding_last_edited=&#8221;on|desktop&#8221; padding_left_right_link_1=&#8221;true&#8221; padding_left_right_link_2=&#8221;true&#8221; _builder_version=&#8221;4.16&#8243; custom_margin=&#8221;7px|||||&#8221; custom_padding=&#8221;39.0156px|0px|0|0px|false|false&#8221; custom_padding_tablet=&#8221;0px|35px|0px|35px&#8221; custom_padding_phone=&#8221;0px||0px&#8221; animation_direction=&#8221;right&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column_inner saved_specialty_column_type=&#8221;3_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|20px||20px&#8221; custom_padding_tablet=&#8221;|0px||0px&#8221; custom_padding_phone=&#8221;||30px&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_button button_url=&#8221;https:\/\/fundraise.givesmart.com\/vf\/Progeria&#8221; button_text=&#8221;Donate today and be ONE to make the cure POSSIBLE! &#8221; button_alignment=&#8221;center&#8221; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;OP Donate Button&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; button_text_size=&#8221;24px&#8221; button_text_color=&#8221;#FFFFFF&#8221; button_bg_color=&#8221;#00B2E2&#8243; button_border_color=&#8221;#29327A&#8221; background_layout=&#8221;dark&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_button][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner column_structure=&#8221;1_3,1_3,1_3&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; padding_left_right_link_1=&#8221;true&#8221; padding_left_right_link_2=&#8221;true&#8221; padding_left_right_link_3=&#8221;true&#8221; admin_label=&#8221;Row&#8221; _builder_version=&#8221;4.27.4&#8243; custom_margin=&#8221;15px||||false|false&#8221; custom_padding=&#8221;5px|30px|0||false|false&#8221; custom_padding_tablet=&#8221;|35px||35px||true&#8221; custom_padding_phone=&#8221;|35px||35px||true&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column_inner type=&#8221;1_3&#8243; saved_specialty_column_type=&#8221;3_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|10px||10px&#8221; custom_padding_tablet=&#8221;||40px&#8221; custom_padding_phone=&#8221;||30px&#8221; custom_padding_last_edited=&#8221;on|tablet&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_blurb title=&#8221;THE HEART OF THE STORY&#8221; image=&#8221;https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2025\/05\/parentjourney2025journey-circle.png&#8221; image_icon_width_tablet=&#8221;&#8221; image_icon_width_phone=&#8221;100%&#8221; image_icon_width_last_edited=&#8221;on|phone&#8221; admin_label=&#8221;THE HEART OF THE STORY THE PARENTS\u2019 PERSPECTIVE&#8221; _builder_version=&#8221;4.27.4&#8243; header_level=&#8221;h3&#8243; header_text_align=&#8221;center&#8221; animation=&#8221;off&#8221; z_index_tablet=&#8221;500&#8243; image_max_width_tablet=&#8221;&#8221; image_max_width_phone=&#8221;100%&#8221; image_max_width_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p class=\"p1\" style=\"text-align: center;\">THE PARENTS\u2019 PERSPECTIVE<\/p>\n<p class=\"p1\"><strong><span class=\"s1\" style=\"color: #00ccff;\">\u201c<\/span><span class=\"s2\"> <\/span>Her heart is what makes her so special. <span class=\"s1\" style=\"color: #00ccff;\">\u201d<\/span><\/strong><\/p>\n<p class=\"p2\">Kristy and Joe\u2019s 21-year-old daughter Lindsay, was diagnosed with Progeria at age 3.<\/p>\n<p class=\"p2\">Kristy says, \u201cLindsay was always her own toughest critic. She didn\u2019t just try her best, she expected the best from herself. That drive, that determination\u2014it\u2019s just who she is.\u201d<\/p>\n<p class=\"p2\">\u201cAnd she\u2019s everyone\u2019s biggest cheerleader. Her heart is what makes her so special,\u201d Joe says with pride.<\/p>\n<p class=\"p1\"><strong><span class=\"s1\" style=\"color: #00ccff;\">\u201c<\/span><span class=\"s2\"> <\/span>PRF is family. <span class=\"s1\" style=\"color: #00ccff;\">\u201d<\/span><\/strong><\/p>\n<p class=\"p2\">Kristy and Joe\u2019s journey to help their daughter started with PRF guiding them to researchers at the National Institutes of Health, the trial team at Boston Children\u2019s Hospital, and PRF\u2019s many resources. They were struck by something powerful: \u201cThey didn\u2019t treat Lindsay like a patient or dismiss our concerns, they treated us like family. PRF is family.\u201d<\/p>\n<p>[\/et_pb_blurb][\/et_pb_column_inner][et_pb_column_inner type=&#8221;1_3&#8243; saved_specialty_column_type=&#8221;3_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|10px||10px&#8221; custom_padding_tablet=&#8221;||40px&#8221; custom_padding_phone=&#8221;||30px&#8221; custom_padding_last_edited=&#8221;on|desktop&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_blurb title=&#8221;LINDSAY\u2019S JOURNEY&#8221; image=&#8221;https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2025\/05\/Lindsay2025journey-circle.png&#8221; image_icon_width_tablet=&#8221;&#8221; image_icon_width_phone=&#8221;100%&#8221; image_icon_width_last_edited=&#8221;on|phone&#8221; admin_label=&#8221;Lindsay&#8217;s journey&#8221; _builder_version=&#8221;4.27.4&#8243; header_level=&#8221;h3&#8243; header_text_align=&#8221;center&#8221; animation=&#8221;off&#8221; z_index_tablet=&#8221;500&#8243; image_max_width_tablet=&#8221;&#8221; image_max_width_phone=&#8221;100%&#8221; image_max_width_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p class=\"p1\" style=\"text-align: center;\">FROM DIAGNOSIS TO DREAMS<\/p>\n<p class=\"p1\">Lindsay began coming to Boston for the PRF-funded clinical trials when she was just 3 years old!<\/p>\n<p class=\"p2\">Today, Lindsay is thriving at Albion College. Now a junior, she\u2019s double majoring in English and Political Science, Vice President of her sorority, and a fierce advocate for people with disabilities. She\u2019s an honor student, award-winning writer and scholar, and is working on a thesis that explores the use of poetry to express disability in medical and social contexts.<\/p>\n<p class=\"p2\"><strong>Her dream?<\/strong> To work in publishing, helping people bring their words into the world. Lindsay knows that because of PRF\u2019s support and the breakthroughs in treatment and research, that dream is within reach.<\/p>\n<p>[\/et_pb_blurb][\/et_pb_column_inner][et_pb_column_inner type=&#8221;1_3&#8243; saved_specialty_column_type=&#8221;3_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|10px||10px&#8221; custom_padding_tablet=&#8221;||40px|&#8221; custom_padding_phone=&#8221;||30px&#8221; custom_padding_last_edited=&#8221;on|desktop&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_blurb title=&#8221;THE POWER OF PRF &#8211; AND YOU!&#8221; image=&#8221;https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2025\/05\/lindsay-alessandroaudrey2025-circle.png&#8221; image_icon_width_tablet=&#8221;&#8221; image_icon_width_phone=&#8221;100%&#8221; image_icon_width_last_edited=&#8221;on|phone&#8221; admin_label=&#8221;THE POWER OF PRF &#8211; AND YOU!&#8221; _builder_version=&#8221;4.27.4&#8243; header_level=&#8221;h3&#8243; header_text_align=&#8221;center&#8221; animation=&#8221;off&#8221; z_index_tablet=&#8221;500&#8243; image_max_width_tablet=&#8221;&#8221; image_max_width_phone=&#8221;100%&#8221; image_max_width_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p class=\"p1\">Lindsay embodies the same drive, compassion, and leadership that define The Progeria Research Foundation.<\/p>\n<p class=\"p1\">PRF is driving every major discovery, compassionately ensuring those with Progeria get the unique care they need, and leading the charge to the cure.<\/p>\n<p class=\"p1\">Fueled by purpose and driven by results, PRF is a leader in rare disease research with its focus, innovation, and measurable impact. But we\u2019re not finished. <strong><em>Lindsay\u2019s future &#8211; and the future of every child with Progeria &#8211; depends on what we do next.<\/em><\/strong> We must continue to fund drug and gene therapy development \u2013 For the Children \u2665 For the Cure.<\/p>\n<p class=\"p1\"><strong>Please join us and be ONE to make a cure \u2013 and many more stories like Lindsay\u2019s &#8211; POSSIBLE.<\/strong><\/p>\n<p>[\/et_pb_blurb][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner _builder_version=&#8221;4.16&#8243; background_color=&#8221;#00b2e2&#8243; custom_margin=&#8221;41px||&#8221; custom_margin_tablet=&#8221;0px||&#8221; custom_margin_phone=&#8221;&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; custom_padding=&#8221;39.4375px|61px|0|61px|false|true&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;top&#8221; animation_intensity_slide=&#8221;25%&#8221; box_shadow_style=&#8221;preset1&#8243; box_shadow_blur=&#8221;38px&#8221; box_shadow_spread=&#8221;-12px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column_inner saved_specialty_column_type=&#8221;3_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;Meet the teams&#8221; _builder_version=&#8221;4.27.4&#8243; text_font=&#8221;||||||||&#8221; header_font=&#8221;||||||||&#8221; header_2_font=&#8221;||||||||&#8221; header_2_line_height=&#8221;1.2em&#8221; header_3_font=&#8221;||||||||&#8221; header_4_font=&#8221;||||||||&#8221; background_layout=&#8221;dark&#8221; custom_margin=&#8221;||35px|-6px|false|false&#8221; custom_padding=&#8221;|0px|||false|false&#8221; custom_padding_tablet=&#8221;|50px||50px||true&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|desktop&#8221; header_font_size_tablet=&#8221;&#8221; header_font_size_phone=&#8221;&#8221; header_font_size_last_edited=&#8221;on|desktop&#8221; header_2_font_size_tablet=&#8221;25px&#8221; header_2_font_size_phone=&#8221;25px&#8221; header_2_font_size_last_edited=&#8221;on|tablet&#8221; header_4_font_size_tablet=&#8221;&#8221; header_4_font_size_phone=&#8221;19px&#8221; header_4_font_size_last_edited=&#8221;on|phone&#8221; header_4_line_height_tablet=&#8221;&#8221; header_4_line_height_phone=&#8221;1.2em&#8221; header_4_line_height_last_edited=&#8221;on|phone&#8221; z_index_tablet=&#8221;500&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h1 style=\"text-align: center;\"><span style=\"color: #ffffff;\">Meet the 2025 PRF ONEpossible Teams<\/span><\/h1>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner column_structure=&#8221;1_3,1_3,1_3&#8243; custom_padding_last_edited=&#8221;on|desktop&#8221; padding_left_right_link_1=&#8221;true&#8221; padding_left_right_link_2=&#8221;true&#8221; _builder_version=&#8221;4.27.4&#8243; custom_margin=&#8221;|30px|||false|false&#8221; custom_padding_tablet=&#8221;0px|35px||35px&#8221; custom_padding_phone=&#8221;0px||0px&#8221; animation_direction=&#8221;right&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column_inner type=&#8221;1_3&#8243; saved_specialty_column_type=&#8221;3_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|20px||20px&#8221; custom_padding_tablet=&#8221;|0px||0px&#8221; custom_padding_phone=&#8221;||30px&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;TEAM KAYLEE&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; link_option_url=&#8221;https:\/\/fundraise.givesmart.com\/vf\/Progeria\/team\/Kaylee&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3 style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-20530 aligncenter \" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2025\/05\/Kayleescarf-thumbnail.jpg\" alt=\"\" width=\"319\" height=\"319\" \/><strong>TEAM KAYLEE<\/strong><\/h3>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;TEAM ZOEY&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; link_option_url=&#8221;https:\/\/fundraise.givesmart.com\/vf\/Progeria\/team\/Zoey&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3 style=\"text-align: center;\"><strong><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-20533 aligncenter \" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2025\/05\/Zoey-John-thumbnail-1.jpg\" alt=\"\" width=\"325\" height=\"325\" \/>TEAM ZOEY<\/strong><\/h3>\n<p>[\/et_pb_text][\/et_pb_column_inner][et_pb_column_inner type=&#8221;1_3&#8243; saved_specialty_column_type=&#8221;3_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|20px|30px|20px&#8221; custom_padding_tablet=&#8221;|0px||0px&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|desktop&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;TEAM LINDSAY&#8221; _builder_version=&#8221;4.27.4&#8243; 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_builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2025\/02\/20250129_Poster_Progeria_final.jpg&#8221; title_text=&#8221;20250129_Poster_Progeria_final&#8221; url=&#8221;https:\/\/www.charitynavigator.org\/ein\/043460220&#8243; align=&#8221;center&#8221; admin_label=&#8221;logos&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; max_width=&#8221;100%&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text _builder_version=&#8221;4.27.4&#8243; text_font_size=&#8221;18px&#8221; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<div class=\"elementToProof\">\n<p>The Center for Research in Molecular Medicine and Chronic Diseases (CiMUS) at the University of Santiago in Spain invited PRF co-founders to share their story at a special Rare Disease Day 2025 event.<\/p>\n<p>Organized and moderated by PRF researcher, Dr. Ricardo Villa-Bellosta, Drs. Gordon and Berns will shared the latest research advancements impacting the field of Progeria research and the journey of bringing Progeria from obscurity to gene finding, to treatment, to global awareness and a possible cure on the horizon! They were also joined by Esther Martinez Gracia, mother to Alexandra Perault and long-time friend and supporter of PRF.<\/p>\n<p>For more info on the event,<a href=\"https:\/\/cimus.usc.gal\/events\/rare-disease-day-progeria-1\"> click here<\/a>.<\/p>\n<p>The event inspired extensive media coverage, such as <a href=\"https:\/\/www.antena3.com\/noticias\/sociedad\/padres-alexandra-nina-enfermedad-rara-importante-rendirse-aprovechar-cada-momento_2025030267c4b1341ba31400010be3d8.html\">&#8220;<b>The parents of Alexandra, a girl with a rare disease: &#8220;The important thing is not to give up and to take advantage of every moment&#8221;<\/b><\/a><\/p>\n<\/div>\n<p>[\/et_pb_text][et_pb_testimonial quote_icon_color=&#8221;#FFFFFF&#8221; quote_icon_background_color=&#8221;#00B2E2&#8243; admin_label=&#8221;quote&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; body_font=&#8221;|700|||||||&#8221; body_font_size=&#8221;18px&#8221; background_color=&#8221;#8FD2ED&#8221; background_layout=&#8221;dark&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Following her diagnosis, the family looked for options to treat the disease, and that&#8217;s when they learned about The Progeria Research Foundation (PRF), an American organization dedicated to researching progeria. Through this foundation, Alexandra was able to enter a clinical trial testing a drug called lonafarnib that does not cure the disease, but has been shown to increase patients&#8217; life expectancy by 30%.<\/p>\n<p><i>~<\/i><span>Esther Mart\u00ednez Gracia, Mother of Alexandra and President of the Spanish Progeria Association<\/span><\/p>\n<p>[\/et_pb_testimonial][et_pb_image src=&#8221;https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2025\/02\/cimus-group-1024&#215;683.jpg&#8221; title_text=&#8221;cimus group&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;14px&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>(From left): David Ara\u00fajo Vilar, CiMUS researcher and President-Founder of the Spanish Society of Lipodystrophies; Mabel Loza Garc\u00eda, CiMUS Scientific Director; PRF Co-Founder and Medical Director, Dr. Leslie Gordon; Gumersindo Feijoo Costa, Representative of the University of Santiago de Compostela, Vice-chancellor\u2019s office for Digital Transformation and Innovation; Carmen Cotelo Queijo, Representative of the Galician Government, Director of the Galician Innovation Agency; Esther Mart\u00ednez Gracia, Mother of Alexandra and President of the Spanish Progeria Association; PRF Co-Founder and Board Chair, Dr. Scott Berns; Ricardo Villa Bellosta, CiMUS researcher and PRF grantee<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u05d4\u05de\u05e8\u05db\u05d6 \u05dc\u05de\u05d7\u05e7\u05e8 \u05d1\u05e8\u05e4\u05d5\u05d0\u05d4 \u05de\u05d5\u05dc\u05e7\u05d5\u05dc\u05e8\u05d9\u05ea \u05d5\u05de\u05d7\u05dc\u05d5\u05ea \u05db\u05e8\u05d5\u05e0\u05d9\u05d5\u05ea (CiMUS) \u05d1\u05d0\u05d5\u05e0\u05d9\u05d1\u05e8\u05e1\u05d9\u05d8\u05ea \u05e1\u05e0\u05d8\u05d9\u05d0\u05d2\u05d5 \u05d1\u05e1\u05e4\u05e8\u05d3 \u05d4\u05d6\u05de\u05d9\u05df \u05d0\u05ea \u05de\u05d9\u05d9\u05e1\u05d3\u05d9 PRF \u05dc\u05e9\u05ea\u05e3 \u05d0\u05ea \u05e1\u05d9\u05e4\u05d5\u05e8\u05dd \u05d1\u05d0\u05d9\u05e8\u05d5\u05e2 \u05de\u05d9\u05d5\u05d7\u05d3 \u05d1\u05d9\u05d5\u05dd \u05d4\u05de\u05d7\u05dc\u05d5\u05ea \u05d4\u05e0\u05d3\u05d9\u05e8\u05d5\u05ea 2025.<\/p>","protected":false},"author":2,"featured_media":20138,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[3,1],"tags":[],"class_list":["post-20127","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-events","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Rare Disease Day 2025 I The Progeria Research Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.progeriaresearch.org\/he\/2025\/05\/27\/rdd-2025-cimus\/\" \/>\n<meta property=\"og:locale\" content=\"he_IL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Rare Disease Day 2025 I The Progeria Research Foundation\" \/>\n<meta property=\"og:description\" content=\"The Center for Research in Molecular Medicine and Chronic Diseases (CiMUS) at the University of Santiago in Spain invited PRF co-founders to share their story at a special event on Rare Disease Day 2025.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.progeriaresearch.org\/he\/2025\/05\/27\/rdd-2025-cimus\/\" \/>\n<meta property=\"og:site_name\" content=\"The Progeria Research Foundation\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ProgeriaResearch\/\" \/>\n<meta property=\"article:published_time\" content=\"2025-05-27T12:31:55+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-18T13:54:30+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2025\/02\/RDD-for-post.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1000\" \/>\n\t<meta property=\"og:image:height\" content=\"1000\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Karen Betournay\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@Progeria\" \/>\n<meta name=\"twitter:site\" content=\"@Progeria\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Karen Betournay\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 \u05d3\u05e7\u05d5\u05ea\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.progeriaresearch.org\\\/2025\\\/05\\\/27\\\/rdd-2025-cimus\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.progeriaresearch.org\\\/2025\\\/05\\\/27\\\/rdd-2025-cimus\\\/\"},\"author\":{\"name\":\"Karen Betournay\",\"@id\":\"https:\\\/\\\/www.progeriaresearch.org\\\/ta\\\/#\\\/schema\\\/person\\\/2be6cec85c11aaef7a7602636c5b9946\"},\"headline\":\"PRF Co-Founders Drs. 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