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\u092e\u0908 2018 \u092e\u0947\u0902, \u092e\u0947\u0902 \u092a\u094d\u0930\u0915\u093e\u0936\u093f\u0924 \u0905\u0927\u094d\u092f\u092f\u0928 \u0915\u0947 \u0924\u0941\u0930\u0902\u0924 \u092c\u093e\u0926 \u091c\u093e\u092e\u093e<\/em>, \u092a\u0940\u0906\u0930\u090f\u092b \u0914\u0930 \u0908\u0917\u0930 \u092c\u093e\u092f\u094b\u092b\u093e\u0930\u094d\u092e\u093e\u0938\u094d\u092f\u0941\u091f\u093f\u0915\u0932\u094d\u0938 \u0928\u0947 \u092c\u091a\u094d\u091a\u094b\u0902 \u092e\u0947\u0902 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0915\u0947 \u0909\u092a\u091a\u093e\u0930 \u0915\u0947 \u0932\u093f\u090f \u0932\u094b\u0928\u093e\u092b\u093e\u0930\u094d\u0928\u093f\u092c \u0915\u0947 \u0935\u093f\u0915\u093e\u0938 \u0914\u0930 \u0905\u092e\u0947\u0930\u093f\u0915\u0940 \u0916\u093e\u0926\u094d\u092f \u090f\u0935\u0902 \u0914\u0937\u0927\u093f \u092a\u094d\u0930\u0936\u093e\u0938\u0928 \u0915\u0940 \u0938\u092e\u0940\u0915\u094d\u0937\u093e \u0914\u0930 \u0938\u0902\u092d\u093e\u0935\u093f\u0924 \u0905\u0928\u0941\u092e\u094b\u0926\u0928 \u0915\u0947 \u0932\u093f\u090f \u0938\u0939\u092f\u094b\u0917 \u0914\u0930 \u0906\u092a\u0942\u0930\u094d\u0924\u093f \u0938\u092e\u091d\u094c\u0924\u0947 \u092a\u0930 \u0939\u0938\u094d\u0924\u093e\u0915\u094d\u0937\u0930 \u0915\u093f\u090f\u0964 \u092b\u093e\u0907\u0932\u093f\u0902\u0917 23 \u092e\u093e\u0930\u094d\u091a 2020 \u0915\u094b \u092a\u0942\u0930\u0940 \u0939\u0941\u0908\u0964 <\/a>\u0928\u0935\u0902\u092c\u0930, 2020 \u092e\u0947\u0902, \u0932\u094b\u0928\u093e\u092b\u093e\u0930\u094d\u0928\u093f\u092c \u0928\u0947 \u0907\u0924\u093f\u0939\u093e\u0938 \u0930\u091a \u0926\u093f\u092f\u093e \u0905\u092e\u0947\u0930\u093f\u0915\u0940 \u0916\u093e\u0926\u094d\u092f \u090f\u0935\u0902 \u0914\u0937\u0927\u093f \u092a\u094d\u0930\u0936\u093e\u0938\u0928 (\u090f\u092b\u0921\u0940\u090f) \u0938\u0947 \u0905\u0928\u0941\u092e\u094b\u0926\u0928 \u092a\u094d\u0930\u093e\u092a\u094d\u0924 \u0915\u0930\u0928\u0947 \u0935\u093e\u0932\u093e \u092a\u0939\u0932\u093e \u0909\u092a\u091a\u093e\u0930<\/a> \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0914\u0930 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u094b\u0907\u0921 \u0932\u0947\u092e\u093f\u0928\u094b\u092a\u0948\u0925\u0940 \u0915\u0947 \u0932\u093f\u090f\u0964<\/p>\n

\u0905\u092c \u0939\u092e\u093e\u0930\u0947 \u092a\u093e\u0938 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0915\u0947 \u0932\u093f\u090f \u090f\u0915 \u0909\u092a\u091a\u093e\u0930 \u0939\u0948, \u0932\u0947\u0915\u093f\u0928 \u092f\u0939 \u0907\u0932\u093e\u091c \u0928\u0939\u0940\u0902 \u0939\u0948, \u0907\u0938\u0932\u093f\u090f \u0939\u092e \u0910\u0938\u0940 \u0926\u0935\u093e\u0913\u0902 \u0915\u0940 \u0916\u094b\u091c \u0915\u0947 \u0932\u093f\u090f \u0905\u0928\u0941\u0938\u0902\u0927\u093e\u0928 \u091c\u093e\u0930\u0940 \u0930\u0916 \u0930\u0939\u0947 \u0939\u0948\u0902 \u091c\u094b \u0914\u0930 \u092d\u0940 \u0905\u0927\u093f\u0915 \u092a\u094d\u0930\u092d\u093e\u0935\u0940 \u0939\u094b\u0902\u0917\u0940, \u0924\u0925\u093e \u0905\u0902\u0924\u0924\u0903 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0915\u093e \u0907\u0932\u093e\u091c \u0915\u0930 \u0938\u0915\u0947\u0902\u0917\u0940\u0964<\/p>\n

[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][\/et_pb_section][et_pb_section fb_built=”1″ module_class=”footer” _builder_version=”4.3.4″ background_color=”#29327a” custom_margin=”25px|||||” custom_padding=”0|0px|0|0px|false|false” z_index_tablet=”500″ border_width_top=”12px” border_color_top=”#00b2e2″ global_module=”133″ locked=”off” global_colors_info=”{}”][et_pb_row column_structure=”1_4,1_4,1_2″ make_equal=”on” module_class=” et_pb_row_fullwidth” _builder_version=”4.16″ width=”89%” width_tablet=”80%” width_phone=”” width_last_edited=”on|desktop” max_width=”89%” max_width_tablet=”80%” max_width_phone=”” max_width_last_edited=”on|desktop” z_index_tablet=”500″ make_fullwidth=”on” width_unit=”off” custom_width_percent=”100%” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_cta button_url=”https:\/\/www.progeriaresearch.org\/newsletter-signup\/” button_text=”Sign Up Now” admin_label=”Sign Up for Newsletter” module_class=”sign-btn” _builder_version=”4.16″ header_font_size=”25px” background_color=”#29327a” animation_style=”slide” animation_direction=”left” animation_intensity_slide=”25%” header_font_size_tablet=”” header_font_size_phone=”30px” header_font_size_last_edited=”on|desktop” z_index_tablet=”500″ border_radii=”on|25px|25px|25px|25px” global_colors_info=”{}” button_bg_color__hover_enabled=”on” button_bg_color__hover=”#8fd2ed” button_border_color__hover_enabled=”on”]<\/p>\n

\u0938\u093e\u0907\u0928 \u0905\u092a \u0915\u0930\u0947\u0902<\/h2>\n

\u0939\u092e\u093e\u0930\u0947 \u0932\u093f\u090f<\/h2>\n

\u0938\u092e\u093e\u091a\u093e\u0930 \u092a\u0924\u094d\u0930\u093f\u0915\u093e!<\/h2>\n

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[\/et_pb_cta][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2021\/06\/June2021hp4temppsd.png” title_text=”June2021hp4temppsd” _builder_version=”4.16″ _module_preset=”default” custom_margin=”35px||||false|false” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” disabled_on=”off|off|off” _builder_version=”4.16″ border_width_bottom=”55px” border_color_bottom=”#29327a” global_colors_info=”{}”][et_pb_fullwidth_header _builder_version=”4.16″ title_font_size=”55″ background_color=”#29327a” background_image=”https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/About-Header.jpg” background_position=”center_left” custom_padding=”9vw||9vw||true” custom_padding_tablet=”” custom_padding_phone=”|56px||” custom_padding_last_edited=”on|desktop” title_font_size_tablet=”45px” title_font_size_phone=”40px” title_font_size_last_edited=”on|phone” z_index_tablet=”500″ custom_css_main_element=”background-position: center 18% !important;” global_colors_info=”{}”] The FTI Drug [\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ use_custom_gutter=”on” gutter_width=”1″ specialty=”on” padding_left_1=”35px” padding_left_2=”35px” padding_2_tablet=”|||0px” padding_2_phone=”|||0px” padding_2_last_edited=”on|desktop” module_class_1=”sidebar-secondary-nav” module_class=”handprint-bg” _builder_version=”4.16″ background_image=”https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/blue-handprint-only.png” parallax=”on” parallax_method=”off” inner_width=”100%” inner_max_width=”100%” custom_padding=”0|0px|54px|0px|false|false” z_index_tablet=”500″ border_width_top=”10px” border_color_top=”#8fd2ed” use_custom_width=”on” width_unit=”off” custom_width_percent=”100%” global_colors_info=”{}”][et_pb_column […]<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"\t\t\t\t[vc_row][vc_column][vc_custom_heading text=\"The FTI Drug Lonafarnib\" font_container=\"tag:h1|text_align:center\" use_theme_fonts=\"yes\"][vc_custom_heading text=\"The FTI lonafarnib \u2013 the first and only known drug treatment for children with Progeria\" use_theme_fonts=\"yes\"][vc_column_text]In August 2005 and February 2006, researchers published studies that supported a potential drug treatment for children with Progeria. Farnesyltransferase inhibitors (FTIs)<\/b>, originally developed to potentially treat cancer, reversed the dramatic nuclear structure abnormalities that are the hallmark of cells from children with Progeria. In addition, this FTI drug improves some signs of disease in a Progeria-like mouse model.\r\n\r\nWhy did researchers think this drug would work in Progeria?<\/b> The protein that we believe is responsible for Progeria is called progerin.\u00a0In order to block normal cell function and cause Progeria, a molecule called a \u201cfarnesyl group\u201d must be attached to the progerin protein. FTIs act by blocking (inhibiting) the attachment of the farnesyl group onto progerin. \u00a0So if the FTI drug can block this farnesyl group attachment in children with Progeria, then progerin may be \u201cparalyzed\u201d and Progeria improved.\r\n\r\nFor the first time, we had in front of us a possible treatment for children with Progeria.\u00a0<\/b>A first-ever clinical drug trial<\/b><\/a>\u00a0began in 2007, and in 2012 <\/b>the study results were published, demonstrating that every child experienced improvement in one or more areas, including the vital cardiovascular system.\u00a0 In May 2014, further study revealed lonafarnib increases estimated lifespan by at least 1.6 years (time will tell if that number increases \u2013 it just hasn\u2019t been long enough to determine)\u00a0and in April 2018 a study published in The Journal of the American Medical Association (JAMA)<\/em> reported that lonafarnib alone extended survival in children with Progeria. \u00a0Click here<\/b><\/a> for details on the 2012 study,\u00a0here<\/b> <\/a>for details on the 2014 findings, and here<\/a><\/strong> for details on the 2018 study.\r\n\r\nIn May 2018, on the heels of the study published in JAMA<\/em>, PRF and Eiger Biopharmaceuticals entered into collaboration and supply agreement for the development and pursuit of U.S. Food and Drug Administration review and potential approval of lonafarnib for the treatment of Progeria in children. Lonafarnib will mark the first therapy submitted to the FDA for the treatment of Progeria.\r\n\r\nWe now have one treatment for Progeria but it is not a cure, so we continue to drive the research to discover drugs that will be even more effective, and ultimately cure Progeria.[\/vc_column_text][\/vc_column][\/vc_row]\t\t","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-796","page","type-page","status-publish","hentry"],"yoast_head":"\nThe FTI Drug | The Progeria Research Foundation<\/title>\n<meta name=\"description\" content=\"Farnesyltransferase inhibitors (FTIs) is the first and only known drug treatment for children with Progeria.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.progeriaresearch.org\/hi\/the-fti-drug\/\" \/>\n<meta property=\"og:locale\" content=\"hi_IN\" \/>\n<meta property=\"og:type\" 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