{"id":2113,"date":"2006-02-16T20:28:04","date_gmt":"2006-02-16T20:28:04","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?p=2113"},"modified":"2020-12-09T11:16:33","modified_gmt":"2020-12-09T16:16:33","slug":"three-studies-released-that-bring-us-closer-than-ever-to-understanding-progeria-and-to-disease-treatment","status":"publish","type":"post","link":"https:\/\/www.progeriaresearch.org\/id\/2006\/02\/16\/three-studies-released-that-bring-us-closer-than-ever-to-understanding-progeria-and-to-disease-treatment\/","title":{"rendered":"Tiga studi yang dirilis membawa kita lebih dekat dari sebelumnya untuk memahami Progeria dan pengobatan penyakit tersebut"},"content":{"rendered":"

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Para peneliti UCLA yang didanai PRF telah mengambil model tikus mirip Progeria dan menguji pengobatan obat yang potensial untuk anak-anak penderita Progeria. Studi mereka yang dirilis di Science pada 16 Februari telah menemukan bahwa obat FTI ini memperbaiki beberapa tanda penyakit tersebut.<\/p>\n

Pada bulan September, Yayasan Penelitian Progeria dengan senang hati mengumumkan bahwa para peneliti yang didanai PRF telah menerbitkan studi yang mendukung pengobatan obat potensial untuk anak-anak penderita Progeria \u2013 Sel-sel Progeria menjadi normal (dalam cawan) ketika diberikan obat ini. Tahap pengujian berikutnya telah dilakukan pada model hewan, dan kami gembira melaporkan bahwa sebuah studi yang dirilis di Science pada tanggal 16 Februari telah menemukan bahwa obat FTI ini memperbaiki beberapa tanda penyakit pada model tikus yang mirip dengan progeria. PRF membantu mendanai para peneliti UCLA Dr. Loren Fong dan Dr. Stephen Young untuk langkah penting terbaru ini menuju uji coba pengobatan klinis pada anak-anak. Klik di sini untuk detail lebih lanjut<\/a> pada berita menarik ini.<\/p>\n

Dan publikasi ilmiah terus berlanjut! PRF mendanai sebuah studi yang dilakukan oleh Dr. Karima Djabali, bersama dengan Dr. Dayle McClintock dan Direktur Medis PRF Dr. Leslie B. Gordon, yang baru saja dipublikasikan di PNAS minggu ini. (Prosiding Akademi Ilmu Pengetahuan Nasional).<\/em> Studi ini menyimpulkan bahwa protein cacat yang diproduksi oleh gen Progeria (disebut progerin) terbentuk di sel-sel dinding pembuluh darah anak-anak. Ini menunjukkan kepada kita, untuk pertama kalinya, bahwa ada hubungan langsung antara progerin dan penyakit jantung.<\/p>\n

Dan yang terakhir, tetapi yang terpenting, laboratorium Dr. Francis Collins, yang menemukan gen Progeria, telah maju terus dan menghasilkan tikus Progeria yang membawa cacat genetik yang identik dengan anak-anak tersebut. Model tikus Progeria klasik ini menunjukkan penyakit pembuluh darah yang parah, dan akan menjadi penting bagi pemahaman kita tidak hanya bagaimana anak-anak dengan Progeria mengembangkan penyakit jantung, tetapi yang lebih penting lagi akan menjadi model yang sangat baik untuk menguji perawatan baru seperti FTI dan terapi genetik dalam mengobati dan menyembuhkan Progeria. Dan model ini juga dapat digunakan untuk mengeksplorasi penyakit kardiovaskular secara umum. Kami bangga untuk mengatakan bahwa Direktur Medis kami, Dr. Leslie B. Gordon, adalah salah satu penulis. Studi tersebut muncul di PNAS minggu ini.<\/p>\n

Salinan kedua artikel PNAS dapat ditemukan di situs web Proceedings of the National Academies of Science di www.pnas.org<\/a><\/p>\n

Tiga penelitian dalam satu bulan \u2013 WOW! Kami benar-benar berusaha keras untuk menemukan obatnya. Terima kasih kepada semua peneliti yang bekerja keras setiap hari untuk membantu anak-anak penderita Progeria dan jutaan orang yang menderita penyakit jantung di seluruh dunia. Dan terima kasih kepada keluarga dan anak-anak, dan semua donatur kami yang telah membuat semua ini menjadi mungkin.<\/strong><\/p>\n

BERSAMA-SAMA, KITA AKAN<\/em> TEMUKAN OBATNYA!<\/strong><\/p>\n

[\/et_pb_teks][\/et_pb_kolom][\/et_pb_baris][\/et_pb_bagian]<\/p>","protected":false},"excerpt":{"rendered":"

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[vc_custom_heading text=\"Three studies released that bring us closer than ever to understanding Progeria and to disease treatment\" font_container=\"tag:h1|text_align:left\" use_theme_fonts=\"yes\"]PRF-funded, UCLA researchers have taken a Progeria-like mouse model and tested a potential drug treatment for children with Progeria. Their study released in Science Feb.16th has found that this FTI drug improves some signs of the disease.<\/p>

In September The Progeria Research Foundation was pleased to announce that PRF-funded researchers had published studies supporting a potential drug treatment for children with Progeria - Progeria cells became normalized (in a dish) when given this drug. The next phase of testing has been in animal models, and we are excited to report that a study released in Science Feb.16th has found that this FTI drug improves some signs of disease in a progeria-like mouse model. PRF helped fund UCLA researchers Dr. Loren Fong and Dr. Stephen Young for this latest, vital step towards clinical treatment trials with the children. Click here for more details<\/a> on this exciting news.<\/p>

And the scientific publications continue! PRF funded a study by Dr. Karima Djabali, along with Dr. Dayle McClintock and PRF Medical Director Dr. Leslie B. Gordon, which was just published in this week's PNAS (Proceeding of the National Academy of Sciences).<\/em> The study concludes that the defective protein produced by the Progeria gene (called progerin) builds up in cells of the children's vessel walls. This shows us, for the first tine, that there is a direct connection between progerin and heart disease.<\/p>

And last but certainly not least, the laboratory of Dr. Francis Collins, who discovered the gene for Progeria, has forged ahead and produced a Progeria mouse that carries a genetic defect identical to that of the children. This classic Progeria mouse model shows severe vascular disease, and will be pivotal to our understanding not only how children with Progeria develop heart disease, but even more importantly will be excellent models for testing new treatments such as FTI and genetic therapies in treating and curing Progeria, And this model can also be used to explore cardiovascular disease in general. We are proud to say that our Medical Director, Dr. Leslie B. Gordon, is a co-author. The study appears in this week's PNAS.<\/p>

Copies of both PNAS articles can be found at the website of the Proceedings of the National Academies of Science at www.pnas.org<\/a><\/p>

Three studies in one month - WOW! We are really cooking towards the cure. Thank you to all of those researchers who are working hard every day to help children with Progeria and the millions of people who suffer from heart disease throughout the world. And thanks to the families and children, and all of our donors for making this all possible.<\/strong><\/p>

TOGETHER, WE WILL<\/em> FIND THE CURE!<\/strong><\/p>","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-2113","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"yoast_head":"\nThree studies released that bring us closer than ever to understanding Progeria and to disease treatment - The Progeria Research Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.progeriaresearch.org\/id\/2006\/02\/16\/three-studies-released-that-bring-us-closer-than-ever-to-understanding-progeria-and-to-disease-treatment\/\" \/>\n<meta property=\"og:locale\" content=\"id_ID\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Three studies released that bring us closer than ever to understanding Progeria and to disease treatment - The Progeria Research Foundation\" \/>\n<meta property=\"og:description\" content=\"[et_pb_section fb_built=”1″ _builder_version=”3.22″][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.6.5″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” hover_enabled=”0″ sticky_enabled=”0″] PRF-funded, UCLA researchers have taken a Progeria-like mouse model and tested a potential drug treatment for children with Progeria. 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