{"id":2135,"date":"2005-05-16T20:48:59","date_gmt":"2005-05-16T20:48:59","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?p=2135"},"modified":"2020-12-09T10:24:44","modified_gmt":"2020-12-09T15:24:44","slug":"reversal-of-the-cellular-phenotype-in-the-premature-aging-disease-hgps","status":"publish","type":"post","link":"https:\/\/www.progeriaresearch.org\/id\/2005\/05\/16\/reversal-of-the-cellular-phenotype-in-the-premature-aging-disease-hgps\/","title":{"rendered":"Pembalikan fenotipe seluler pada penyakit penuaan dini HGPS"},"content":{"rendered":"<p>[et_pb_section fb_built=\u201d1\u2033 _builder_version=\u201d3.22\u2033][et_pb_row _builder_version=\u201d3.25\u2033 ukuran_latar belakang=\u201dawal\u201d posisi_latar belakang=\u201dkiri_atas\u201d pengulangan_latar belakang=\u201dulangi\u201d][et_pb_column jenis=\u201d4_4\u2033 _builder_version=\u201d3.25\u2033 bantalan_khusus=\u201d|||\u201d bantalan_khusus__hover=\u201d|||\u201d][et_pb_text _builder_version=\u201d4.6.5\u2033 ukuran_latar belakang=\u201dawal\u201d posisi_latar belakang=\u201dkiri_atas\u201d pengulangan_latar belakang=\u201dulangi\u201d hover_enabled=\u201d0\u2033 sticky_enabled=\u201d0\u2033]<\/p>\n<p>Sel dari pasien dengan Sindrom Progeria Hutchinson-Gilford (HGPS) dapat dibuat sehat kembali, menurut temuan para ilmuwan di National Cancer Institute, bagian dari National Institutes of Health.<\/p>\n<p><em>Diterbitkan secara online pada tanggal 6 Maret 2005 di Nature Medicine <a href=\"https:\/\/www.nature.com\/\" target=\"_blank\" rel=\"noopener noreferrer\">www.alam.com<\/a><\/em><\/p>\n<p>Sel-sel dari pasien dengan Sindrom Progeria Hutchinson-Gilford (HGPS) dapat dibuat sehat kembali, menurut temuan para ilmuwan di National Cancer Institute, bagian dari National Institutes of Health. Dengan menggunakan segmen pendek DNA yang dimodifikasi secara khusus, peneliti NCI Paola Scaffidi, PhD, dan Tom Misteli, PhD (keduanya peserta Lokakarya PRF 2003), membalikkan cacat yang terlihat pada sel-sel HGPS dengan menghilangkan protein lamin A yang rusak pada HGPS. Dengan menunjukkan bahwa fenotipe seluler HGPS dapat dipulihkan, penelitian ini membawa para ilmuwan selangkah lebih dekat untuk menyembuhkan penyakit anak-anak yang mematikan ini.<\/p>\n<p>&quot;Kami mulai bertanya apakah perubahan seluler yang terkait dengan Progeria ini bersifat permanen atau dapat dibalikkan,&quot; kata Scaffidi. Para peneliti merancang &quot;Band-Aid\u00ae molekuler,&quot; kata Misteli (oligonukleotida DNA yang stabil secara kimia - sehingga sel tidak dapat merusaknya.) Seminggu kemudian, protein lamin A mutan telah dihilangkan dan lebih dari 90 persen sel progeria tampak normal; dan aktivitas beberapa gen yang salah diatur pada pasien HGPS juga dikembalikan ke normal. &quot;Sungguh menakjubkan bahwa kami dapat mengambil sel yang sakit dan beberapa hari kemudian menjadi sehat dan siap untuk membelah lagi,&quot; kata Misteli.<\/p>\n<p>Ia mencatat bahwa hasil ini menunjukkan bukti prinsip bahwa efek seluler Progeria dapat dibalik, yang berarti metode laboratoriumnya suatu hari nanti dapat digunakan sebagai strategi terapi.<\/p>\n<p><strong>Penurunan kadar kolesterol \u201cbaik\u201d pada anak-anak penderita Progeria dapat menyebabkan penyakit jantung dini.<\/strong> Adiponektin \u2013 hormon yang mengatur metabolisme lemak dan gula \u2013 mungkin membantu dalam menemukan pengobatan.<br \/><em>Jurnal Pediatri, Maret 2005<\/em><\/p>\n<p>Sebuah tim peneliti yang dipimpin oleh Direktur Medis PRF dan Asisten Profesor Sekolah Kedokteran Universitas Tufts Leslie Gordon, MD, PhD, menemukan bahwa anak-anak dengan Progeria di pertengahan dan akhir tahun mereka memiliki kadar kolesterol HDL yang menurun \u2013 atau kolesterol \u201cpelindung\u201d \u2013 dan adiponektin, hormon yang mengatur metabolisme lemak dan gula. Kedua faktor tersebut bekerja untuk menghilangkan lemak dari plak di arteri, dan kadar yang lebih rendah dapat berkontribusi pada percepatan pembentukan plak. \u201cSemua anak dengan Progeria meninggal antara usia 6 dan 20 tahun karena gagal jantung atau stroke,\u201d kata Dr. Gordon. \u201cMempelajari penyakit jantung yang berhubungan dengan anak-anak dengan Progeria dapat membantu kita lebih memahami bagaimana aterosklerosis akan memengaruhi populasi yang menua sekaligus membantu anak-anak yang berharga ini.\u201d<\/p>\n<p>\u201cTemuan ini penting bagi pengembangan pengobatan Progeria,\u201d kata penulis senior studi<strong> Alice H. Lichtenstein, DSc, Pusat Penelitian Nutrisi Manusia tentang Penuaan di Universitas Tufts. <\/strong>\u201cJika obat-obatan yang dapat diandalkan untuk meningkatkan kadar kolesterol HDL dan adiponektin tersedia, obat-obatan tersebut dapat terbukti bermanfaat dalam mencegah perkembangan aterosklerosis pada anak-anak penderita Progeria.\u201d<\/p>\n<p>\u201cData ini juga memperkuat pentingnya jaringan adiposa sebagai jaringan aktif yang mengeluarkan hormon yang dapat mempengaruhi fungsi metabolisme seluruh tubuh \u2013 sebuah konsep penting tidak hanya untuk Progeria tetapi juga untuk penyakit yang lebih umum seperti obesitas dan diabetes\u201d, komentar penulis <strong>Mary Elizabeth Patti, MD, Joslin Diabetes Center, dan Departemen Kedokteran, Harvard Medical School, Boston, MA<\/strong><\/p>\n<p>[\/et_pb_teks][\/et_pb_kolom][\/et_pb_baris][\/et_pb_bagian]<\/p>","protected":false},"excerpt":{"rendered":"<p>[et_pb_section fb_built=\u201d1\u2033 _builder_version=\u201d3.22\u2033][et_pb_row _builder_version=\u201d3.25\u2033 ukuran_latar belakang=\u201dawal\u201d posisi_latar belakang=\u201dkiri_atas\u201d pengulangan_latar belakang=\u201dulangi\u201d][et_pb_column jenis=\u201d4_4\u2033 _builder_version=\u201d3.25\u2033 bantalan_khusus=\u201d|||\u201d custom_padding__hover=\u201d|||\u201d][et_pb_text _builder_version=\u201d4.6.5\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201drepeat\u201d hover_enabled=\u201d0\u2033 sticky_enabled=\u201d0\u2033] Sel dari pasien dengan Sindrom Progeria Hutchinson-Gilford (HGPS) dapat dibuat sehat kembali, menurut temuan para ilmuwan di National Cancer Institute, bagian dari National Institutes of Health. Diterbitkan daring pada 6 Maret 2005 di Nature [\u2026]<\/p>","protected":false},"author":1,"featured_media":2043,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"<p>[vc_custom_heading text=\"Reversal of the cellular phenotype in the premature aging disease HGPS\" font_container=\"tag:h1|text_align:left\" use_theme_fonts=\"yes\"]<\/p><div id=\"secondary-header-content\"><div id=\"secondary-header-content\"><p>Cells from patients with Hutchinson-Gilford Progeria Syndrome (HGPS) can be made healthy again, according to findings by scientists at the National Cancer Institute, part of the National Institutes of Health.<\/p><\/div><\/div><p><em>Published online on March 6, 2005 in Nature Medicine <a href=\"https:\/\/www.nature.com\/\">(www.nature.com)<\/a><\/em><\/p><p>Cells from patients with Hutchinson-Gilford Progeria Syndrome (HGPS) can be made healthy again, according to findings by scientists at the National Cancer Institute, part of the National Institutes of Health. Using specially modified short segments of DNA, NCI researchers Paola Scaffidi, PhD, and Tom Misteli, PhD (both 2003 PRF Workshop participants), reversed the defects seen in HGPS cells by eliminating the lamin A protein that is faulty in HGPS. By demonstrating that HGPS cellular phenotypes are reversible, this study brings scientists one step closer to curing this devastating childhood disease.<\/p><p>\"We set out to ask whether these cellular changes associated with Progeria are permanent or can be reversed,\" said Scaffidi. The researchers designed a \"molecular Band-Aid\u00ae,\" said Misteli (a chemically stable DNA oligonucleotide -so the cell wouldn't be able to degrade it.) One week later, the mutant lamin A protein had been eliminated and more than 90 percent of progeria cells looked normal; and the activity of several genes that are misregulated in HGPS patients were also restored to normal. \"It's amazing that we could take a sick cell and a few days later it's healthy and ready to divide again,\" said Misteli.<\/p><p>He noted that these results demonstrate a proof-of-principle that the cellular effects of Progeria can be reversed, meaning his laboratory's method might someday be used as a therapeutic strategy.<\/p><p><strong>Decreased levels of \"good\" cholesterol in children with Progeria may contribute to premature heart disease.<\/strong> Adiponectin - a hormone that regulates the metabolism of fat and sugar - may be helpful in finding treatments.<br \/><em>The Journal of Pediatrics, March 2005<\/em><\/p><p>A team of researchers led by PRF's Medical Director and Tufts University School of Medicine Assistant Professor Leslie Gordon, MD, PhD, discovered that children with Progeria in their mid- and later years have decreased levels of HDL cholesterol - or \"protective\" cholesterol\" - and adiponectin, a hormone that regulates the metabolism of fat and sugar. Both factors work to remove fat from plaques in arteries, and the lower levels may contribute to accelerated plaque formation. \"All children with Progeria die between the ages of 6 and 20 years from heart failure or stroke,\" said Dr. Gordon. \"Studying heart disease as it relates to children with Progeria can help us better understand how atherosclerosis will affect the aging population while also helping these precious children.\"<\/p><p>\"These findings are important for the potential development of a treatment for Progeria,\" said senior study author<strong> Alice H. Lichtenstein, DSc, Human Nutrition Research Center on Aging at Tufts University. <\/strong>\"If reliable drugs used to increase HDL cholesterol and adiponectin levels become available, they may prove beneficial in preventing the progression of atherosclerosis in children with Progeria.\"<\/p><p>\"These data also reinforce the importance of adipose tissue as an active tissue which secretes hormones which can influence metabolic function of the entire body - a concept important not only for Progeria but also for more common diseases such as obesity and diabetes\", comments author <strong>Mary Elizabeth Patti, MD, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, MA<\/strong><\/p>","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-2135","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Reversal of the cellular phenotype in the premature aging disease HGPS - The Progeria Research Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.progeriaresearch.org\/id\/2005\/05\/16\/reversal-of-the-cellular-phenotype-in-the-premature-aging-disease-hgps\/\" \/>\n<meta property=\"og:locale\" content=\"id_ID\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Reversal of the cellular phenotype in the premature aging disease HGPS - The Progeria Research Foundation\" \/>\n<meta property=\"og:description\" content=\"[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;3.22&#8243;][et_pb_row _builder_version=&#8221;3.25&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.6.5&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;] Cells from patients with Hutchinson-Gilford Progeria Syndrome (HGPS) can be made healthy again, according to findings by scientists at the National Cancer Institute, part of the National Institutes of Health. Published online on March 6, 2005 in Nature [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.progeriaresearch.org\/id\/2005\/05\/16\/reversal-of-the-cellular-phenotype-in-the-premature-aging-disease-hgps\/\" \/>\n<meta property=\"og:site_name\" content=\"The Progeria Research Foundation\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ProgeriaResearch\/\" \/>\n<meta property=\"article:published_time\" content=\"2005-05-16T20:48:59+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-12-09T15:24:44+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2011\/05\/1PRFlogo2010_300dpi.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"165\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"gravoc\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@Progeria\" \/>\n<meta name=\"twitter:site\" content=\"@Progeria\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"gravoc\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 menit\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.progeriaresearch.org\/ru\/2005\/05\/16\/reversal-of-the-cellular-phenotype-in-the-premature-aging-disease-hgps\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/ru\/2005\/05\/16\/reversal-of-the-cellular-phenotype-in-the-premature-aging-disease-hgps\/\"},\"author\":{\"name\":\"gravoc\",\"@id\":\"https:\/\/www.progeriaresearch.org\/ta\/#\/schema\/person\/a3c935a81e92242c6a77ae0018542928\"},\"headline\":\"Reversal of the cellular phenotype in the premature aging disease HGPS\",\"datePublished\":\"2005-05-16T20:48:59+00:00\",\"dateModified\":\"2020-12-09T15:24:44+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/ru\/2005\/05\/16\/reversal-of-the-cellular-phenotype-in-the-premature-aging-disease-hgps\/\"},\"wordCount\":620,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/ta\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/ru\/2005\/05\/16\/reversal-of-the-cellular-phenotype-in-the-premature-aging-disease-hgps\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2011\/05\/1PRFlogo2010_300dpi.jpg\",\"articleSection\":[\"News\"],\"inLanguage\":\"id\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.progeriaresearch.org\/ru\/2005\/05\/16\/reversal-of-the-cellular-phenotype-in-the-premature-aging-disease-hgps\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.progeriaresearch.org\/ru\/2005\/05\/16\/reversal-of-the-cellular-phenotype-in-the-premature-aging-disease-hgps\/\",\"url\":\"https:\/\/www.progeriaresearch.org\/ru\/2005\/05\/16\/reversal-of-the-cellular-phenotype-in-the-premature-aging-disease-hgps\/\",\"name\":\"Reversal of the cellular phenotype in the premature aging disease HGPS - 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The Progeria Research Foundation","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.progeriaresearch.org\/id\/2005\/05\/16\/reversal-of-the-cellular-phenotype-in-the-premature-aging-disease-hgps\/","og_locale":"id_ID","og_type":"article","og_title":"Reversal of the cellular phenotype in the premature aging disease HGPS - The Progeria Research Foundation","og_description":"[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;3.22&#8243;][et_pb_row _builder_version=&#8221;3.25&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.6.5&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;] Cells from patients with Hutchinson-Gilford Progeria Syndrome (HGPS) can be made healthy again, according to findings by scientists at the National Cancer Institute, part of the National Institutes of Health. 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