{"id":1012,"date":"2017-02-27T21:28:49","date_gmt":"2017-02-27T21:28:49","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?page_id=1012"},"modified":"2026-06-09T12:35:11","modified_gmt":"2026-06-09T16:35:11","slug":"prf-cell-and-tissue-bank-publications","status":"publish","type":"page","link":"https:\/\/www.progeriaresearch.org\/it\/prf-cell-and-tissue-bank-publications\/","title":{"rendered":"Pubblicazioni della Banca delle cellule e dei tessuti PRF"},"content":{"rendered":"

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PRF Cell and Tissue<\/h1>\n

Bank Publications<\/h1>\n

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Publications Utilizing Material From
<\/b>The Progeria Research Foundation Cell and Tissue Bank<\/b><\/p>\n

<\/a>The Progeria Research Foundation (PRF) provides cell lines, biological material and lonafarnib to researchers around the world to promote research on Progeria and other aging-related diseases.\u00a0 A list of the publications utilizing material from PRF\u2019s Cell and Tissue Bank can be found below.\u00a0 The list is categorized by cell line and other biological sample types for researcher convenience.<\/p>\n

<\/p>\n

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\n\n\n\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t
HGADFN001<\/a><\/td>HGADFN003<\/a><\/td>HGADFN005<\/a><\/td>\n<\/tr>\n
HGADFN008<\/a><\/td>HGADFN014<\/a><\/td>HGMDFN090<\/a><\/td>\n<\/tr>\n
HGADFN122<\/a><\/td>HGADFN127<\/a><\/td>HGADFN136<\/a><\/td>\n<\/tr>\n
HGADFN143<\/a><\/td>HGADFN155<\/a><\/td>HGADFN164<\/a><\/td>\n<\/tr>\n
HGADFN167<\/a><\/td>HGFDFN168<\/a><\/td> HGADFN169<\/a><\/td>\n<\/tr>\n
HGADFN178<\/a><\/td>HGADFN188<\/a><\/td>HGADFN271<\/a><\/td>\n<\/tr>\n
HGADFN367<\/a><\/td>HGMDFN368<\/a><\/td>HGFDFN369<\/a><\/td>\n<\/tr>\n
HGADFN370<\/a><\/td>HGMDFN371<\/a><\/td>HGADFN496<\/a><\/td>\n<\/tr>\n
HGMDFN717<\/a><\/td>HGMDFN718<\/a><\/td>PSADFN086<\/a><\/td>\n<\/tr>\n
PSADFN004<\/a><\/td>PSADFN257<\/a><\/td>PSADFN317<\/a><\/td>\n<\/tr>\n
PSADFN318<\/a><\/td>PSFDFN319<\/a><\/td>PSMDFN320<\/a><\/td>\n<\/tr>\n
PSMDFN326<\/a><\/td>PSFDFN327<\/a><\/td> PSMDFN346<\/a><\/td>\n<\/tr>\n
PSADFN363<\/a><\/td>PSADFN373<\/a><\/td>PSADFN423 <\/a><\/td>\n<\/tr>\n
PSADFN485 <\/a><\/td>PSADFN542 <\/a><\/td>PSADFN386<\/a><\/td>\n<\/tr>\n
PSMDFN371<\/a><\/td>PSMDFN387<\/a><\/td>PSFDFN376<\/a><\/td>\n<\/tr>\n
PSADFN392<\/a><\/td>PSMDFN393<\/a><\/td>PSFDFN388<\/a><\/td>\n<\/tr>\n
PSFDFN394<\/a><\/td>PSADFN414<\/a><\/td>PSADFN425<\/a><\/td>\n<\/tr>\n
HGALBV009<\/a><\/td>HGMLBV010<\/a><\/td>HGALBV011<\/a><\/td>\n<\/tr>\n
HGMLBV013<\/a><\/td>HGFLBV021<\/a><\/td>HGMLBV023<\/a><\/td>\n<\/tr>\n
HGFLBV031<\/a><\/td>HGFLBV050<\/a><\/td>HGALBV057<\/a><\/td>\n<\/tr>\n
HGMLBV058<\/a><\/td>HGSLBV059<\/a><\/td>HGMLBV066<\/a><\/td>\n<\/tr>\n
HGFLBV067<\/a><\/td>HGALBV071<\/a><\/td>HGMLBV081<\/a><\/td>\n<\/tr>\n
HGFLBV082<\/a><\/td>HGADFN003 iPS1B<\/a><\/td>HGADFN003 iPS1C<\/a><\/td>\n<\/tr>\n
HGADFN003 iPS1D<\/a><\/td>HGMDFN090 iPS1B<\/a><\/td>HGMDFN090 iPS1C<\/a><\/td>\n<\/tr>\n
HGADFN167 iPS1J<\/a><\/td>HGADFN167 iPS1Q<\/a><\/td>HGFDFN168 iPS1D2<\/a><\/td>\n<\/tr>\n
HGFDFN168 iPS1P<\/a><\/td>DNA<\/a><\/td>Autopsy tissue<\/a><\/td>\n<\/tr>\n
Plasma<\/a><\/td>Serum<\/a><\/td><\/td>\n<\/tr>\n
Buffy Coats<\/a><\/td>Zokinvy (lonafarnib)<\/a><\/td><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
For publications listed by cell line inclusion, Click here.<\/a><\/strong><\/p>\n

For publications listed by biological sample inclusion, Click here.<\/a><\/strong><\/p>\n

For publications listed by Zokinvy (lonafarnib) inclusion, Click here.<\/a><\/strong><\/p>\n

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HGADFN001<\/strong><\/h4>\n

Age-dependent loss of MMP-3 in Hutchinson-Gilford progeria syndrome.<\/a>
Harten IA, Zahr RS, Lemire JM, Machan JT, Moses MA, Doiron RJ, Curatolo AS, Rothman FG, Wight TN, Toole BP, Gordon LB.\u00a0J Gerontol A Biol Sci Med Sci<\/em>. 2011 Nov;66(11):1201-7.<\/p>\n

The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin.<\/a>
McClintock D, Ratner D, Lokuge M, Owens DM, Gordon LB, Collins FS, Djabali K.\u00a0PLoS One<\/em>. 2007 Dec 5;2(12):e1269.<\/p>\n

Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody.<\/a>
McClintock D, Gordon LB, Djabali K.\u00a0Proc Natl Acad Sci U S A.<\/em>\u00a02006 Feb 14;103(7):2154-9.<\/p>\n

Aggrecan expression is substantially and abnormally upregulated in Hutchinson-Gilford Progeria Syndrome dermal fibroblasts.<\/a>
Lemire JM, Patis C, Gordon LB, Sandy JD, Toole BP, Weiss AS.\u00a0Mech Ageing Dev.<\/em>\u00a02006 Aug;127(8):660-9.<\/p>\n

Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment.<\/a>
Columbaro M, Capanni C, Mattioli E, Novelli G, Parnaik VK, Squarzoni S, Maraldi NM, Lattanzi G.\u00a0Cell Mol Life Sci.<\/em>\u00a02005 Nov;62(22):2669-78.<\/p>\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>
Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS.\u00a0Nature.<\/em>\u00a02003 May 15;423(6937):293-8.<\/p>\n

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HGADFN003<\/strong><\/h4>\n

Transcriptional profiling of Hutchinson-Gilford Progeria patients identifies primary target pathways of progerin<\/a>
Vidak S, Kim S, Misteli T. Preprint.\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125. Published 2025 Sep 20. doi:10.1101\/2025.09.18.677125<\/p>\n

Deregulated miR-145 and miR-27b in hutchinson-gilford progeria syndrome: implications for adipogenesis<\/a>
Fenzl FQ, Lederer EM, Brumma L, et al. Aging (Albany NY)<\/em>. Published online August 27, 2025. doi:10.18632\/aging.206309<\/p>\n

Impact of miR-181a on SIRT1 Expression and Senescence in Hutchinson-Gilford Progeria Syndrome<\/a>
Lederer EM, Fenzl FQ, Kr\u00fcger P, Schroll M, Hartinger R, Djabali K. Diseases<\/em>. 2025;13(8):245. Published 2025 Aug 4. doi:10.3390\/diseases13080245<\/p>\n

Enhancing Cellular Homeostasis: Targeted Botanical Compounds Boost Cellular Health Functions in Normal and Premature Aging Fibroblasts<\/a>
Hartinger R, Singh K, Leverett J, Djabali K. Biomolecules<\/em>. 2024;14(10):1310. Published 2024 Oct 16. doi:10.3390\/biom14101310<\/p>\n

Ghrelin delays premature aging in Hutchinson-Gilford progeria syndrome<\/a>
Ferreira-Marques M, Carvalho A, Franco AC, et al. Ghrelin delays premature aging in Hutchinson-Gilford progeria syndrome [published online ahead of print, 2023 Oct 19].\u00a0Aging Cell<\/em>. 2023;e13983. doi:10.1111\/acel.13983<\/p>\n

Impact of Combined Baricitinib and FTI Treatment on Adipogenesis in Hutchinson-Gilford Progeria Syndrome and Other Lipodystrophic Laminopathies<\/a>
Hartinger R, Lederer EM, Schena E, Lattanzi G, Djabali K. Cells. 2023;12(10):1350. Published 2023 May 9. doi:10.3390\/cells12101350<\/p>\n

Unique progerin C-terminal peptide ameliorates Hutchinson-Gilford progeria syndrome phenotype by rescuing BUBR1.<\/a>
Zhang N, Hu Q, Sui T, Fu L, Zhang X, Wang Y, Zhu X, Huang B, Lu J, Li Z, Zhang Y. Nat Aging. 2023 Feb;3(2):185-201. doi: 10.1038\/s43587-023-00361-w. Epub 2023 Feb 2. Erratum in: Nat Aging. 2023 May 2;: PMID: 37118121; PMCID: PMC10154249.<\/p>\n

Anti-hsa-miR-59 alleviates premature senescence associated with Hutchinson-Gilford progeria syndrome in mice<\/a>
Hu Q, Zhang N, Sui T, et al. [published online ahead of print, 2022 Nov 16].\u00a0EMBO J<\/em>. 2022;e110937. doi:10.15252\/embj.2022110937<\/p>\n

Establishment and Characterization of hTERT Immortalized Hutchinson-Gilford Progeria Fibroblast Cell Lines<\/a>
Lin H, Mensch J, Haschke M, et al. Cells. 2022;11(18):2784. Published 2022 Sep 6. doi:10.3390\/cells11182784<\/p>\n

Impact of MnTBAP and Baricitinib Treatment on Hutchinson-Gilford Progeria Fibroblasts<\/a>
Vehns E, Arnold R, Djabali K. Pharmaceuticals (Basel). 2022;15(8):945. Published 2022 Jul 29. doi:10.3390\/ph15080945<\/p>\n

SerpinE1 drives a cell-autonomous pathogenic signaling in Hutchinson-Gilford progeria syndrome<\/a>
Catarinella G, Nicoletti C, Bracaglia A, et al. Cell Death Dis. 2022;13(8):737. Published 2022 Aug 26. doi:10.1038\/s41419-022-05168-y<\/p>\n

Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate<\/a>
Pfeifer CR, Tobin MP, Cho S, et al. Nucleus. 2022;13(1):129-143. doi:10.1080\/19491034.2022.2045726<\/p>\n

Isoprenylcysteine Carboxylmethyltransferase-Based Therapy for Hutchinson-Gilford Progeria Syndrome<\/a>
Marcos-Ramiro B, Gil-Ord\u00f3\u00f1ez A, Mar\u00edn-Ramos NI, et al. ACS Cent Sci<\/em>. 2021;7(8):1300-1310. doi:10.1021\/acscentsci.0c01698<\/p>\n

Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice<\/a>
Mojiri A, Walther BK, Jiang C, et al. [published online ahead of print, 2021 Aug 14].\u00a0Eur Heart J<\/em>. 2021;ehab547. doi:10.1093\/eurheartj\/ehab547<\/p>\n

Baricitinib, a JAK-STAT Inhibitor, Reduces the Cellular Toxicity of the Farnesyltransferase Inhibitor Lonafarnib in Progeria Cells<\/a>
Arnold R, Vehns E, Randl H, Djabali K.\u00a0Int J Mol Sci<\/em>. 2021;22(14):7474. Published 2021 Jul 12. doi:10.3390\/ijms22147474<\/p>\n

Impact of Progerin Expression on Adipogenesis in Hutchinson-Gilford Progeria Skin-Derived Precursor Cells<\/a>
Najdi F, Kr\u00fcger P, Djabali K. Cells<\/em>. 2021;10(7):1598. Published 2021 Jun 25. doi:10.3390\/cells10071598<\/p>\n

Self-assembly of multi-component mitochondrial nucleoids via phase separation.
<\/a>Feric M, Demarest TG, Tian J, Croteau DL, Bohr VA, Misteli T. EMBO J. 2021 Mar 15;40(6):e107165. doi: 10.15252\/embj.2020107165. Epub 2021 Feb 23. PMID: 33619770; PMCID: PMC7957436.<\/p>\n

Nuclear Pore Complexes Cluster in Dysmorphic Nuclei of Normal and Progeria Cells during Replicative Senescence.
<\/a>R\u00f6hrl JM, Arnold R, Djabali K. Cells. 2021 Jan 14;10(1):153. doi: 10.3390\/cells10010153. PMID: 33466669; PMCID: PMC7828780.<\/p>\n

Inhibition of JAK-STAT Signaling With Baricitinib Reduces Inflammation and Improves Cellular Homeostasis in Progeria Cells<\/a>
Liu C, Arnold R, Henriques G, Djabali K. Cells<\/em> 2019;8(10):1276. Published 2019 Oct 18. doi:10.3390\/cells8101276<\/p>\n

Analysis of Somatic Mutations Identifies Signs of Selection During in Vitro Aging of Primary Dermal Fibroblasts<\/a>
Narisu N, Rothwell R, Vrta\u010dnik P, et al. Aging Cell<\/em> 2019;18(6):e13010. doi:10.1111\/acel.13010<\/p>\n

Transient Introduction of Human Telomerase mRNA Improves Hallmarks of Progeria Cells<\/a>
Li Y, Zhou G, Bruno IG, et al. Aging Cell<\/em>. 2019;18(4):e12979. doi:10.1111\/acel.12979<\/p>\n

Autophagic Removal of Farnesylated Carboxy-Terminal Lamin Peptides<\/a>
Lu X, Djabali K. Cells<\/em> 2018;7(4):33. Published 2018 Apr 23. doi:10.3390\/cells7040033<\/p>\n

Targeting the Phospholipase A2 Receptor Ameliorates Premature Aging Phenotypes<\/a>
Griveau A, Wiel C, Le Calv\u00e9 B, et al. Aging Cell<\/em> 2018;17(6):e12835. doi:10.1111\/acel.12835<\/p>\n

A\u00a0Cell-Intrinsic\u00a0Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.
<\/a>Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S.\u00a0Cell Rep<\/em>. 2018 Feb 20;22(8):2006-2015.<\/p>\n

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies<\/a>
Horvath S, Oshima J, Martin GM, et al. Aging<\/em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632\/aging.101508<\/p>\n

Nucleoplasmic\u00a0lamins\u00a0define\u00a0growth-regulating functions of lamina-associated polypeptide 2\u03b1 in progeria cells.<\/a>\u00a0Vidak S, Georgiou K, Fichtinger P, Naetar N, Dechat T, Foisner R. J Cell Sci. 2017 Dec 28. pii: jcs.208462. doi: 10.1242\/jcs.208462. [Epub ahead of print]<\/p>\n

Intermittent\u00a0treatment\u00a0with\u00a0farnesyltransferase\u00a0inhibitor\u00a0and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts.\u00a0<\/a>Gabriel D, Shafry DD, Gordon LB, Djabali K.\u00a0Oncotarget<\/em>. 2017 Jul 18;8(39):64809-64826. doi: 10.18632\/oncotarget.19363. eCollection 2017 Sep 12.<\/p>\n

Temsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular Phenotype.<\/a>
Gabriel D, Gordon LB, Djabali K. PLoS One<\/em> 2016;11(12):e0168988. Published 2016 Dec 29. doi:10.1371\/journal.pone.0168988<\/p>\n

Progerin Impairs Chromosome Maintenance by Depleting CENP-F From Metaphase Kinetochores in Hutchinson-Gilford Progeria Fibroblasts <\/a>
Eisch V, Lu X, Gabriel D, Djabali K. Oncotarget<\/em> 2016;7(17):24700-24718. doi:10.18632\/oncotarget.8267<\/p>\n

Reprogramming\u00a0progeria\u00a0fibroblasts\u00a0re-establishes a normal epigenetic landscape.<\/a>\u00a0Chen Z, Chang WY, Etheridge A, Strickfaden H, Jin Z, Palidwor G, Cho JH, Wang K, Kwon SY, Dor\u00e9 C, Raymond A, Hotta A, Ellis J, Kandel RA, Dilworth FJ, Perkins TJ, Hendzel MJ, Galas DJ, Stanford WL. .Aging Cell<\/i>. 2017 Jun 8. [Epub ahead of print]Permanent\u00a0farnesylation\u00a0of\u00a0lamin A\u00a0mutants linked to progeria impairs its phosphorylation at serine 22 during interphase.<\/a>\u00a0Moiseeva O, Lopes-Paciencia S, Huot G, Lessard F, Ferbeyre G.\u00a0Aging<\/i>\u00a0. 2016 Feb;8(2):366-81.<\/p>\n

Permanent farnesylation of lamin A mutants linked to progeria impairs its phosphorylation at<\/a> serine 22 during interphase.<\/a>
Moiseeva O, Lopes-Paciencia S, Huot G, Lessard F, Ferbeyre G. Aging<\/em> 2016 Feb;8(2):366-81.<\/p>\n

Vitamin D Receptor Signaling Improves Hutchinson-Gilford Progeria Syndrome Cellular Phenotypes<\/a>
Kreienkamp R, Croke M, Neumann MA, et al. Oncotarget<\/em> 2016;7(21):30018-30031. doi:10.18632\/oncotarget.9065<\/p>\n

Lamin A\u00a0Is an\u00a0Endogenous\u00a0SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair.<\/a>\u00a0Ghosh S, Liu B, Wang Y, Hao Q, Zhou Z.\u00a0Cell Rep<\/i>. 2015 Nov 17;13(7):1396-1406. doi: 10.1016\/j.celrep.2015.10.006. Epub 2015 Nov 5. PMID:26549451<\/p>\n

Proliferation\u00a0of\u00a0progeria\u00a0cells\u00a0is\u00a0enhanced\u00a0by\u00a0lamina-associated polypeptide 2\u03b1 (LAP2\u03b1) through expression of extracellular matrix proteins.
<\/a>Vidak S, Kubben N, Dechat T, Foisner R.\u00a0Genes & Development.<\/i>\u00a02015 Oct 1;29(19):2022-36.<\/p>\n

Sulforaphane\u00a0enhances\u00a0progerin clearance in Hutchinson-Gilford progeria fibroblasts.
<\/a>Gabriel D, Roedl D, Gordon LB, Djabali K.\u00a0Aging Cell<\/i>. 2014 Dec 16: 1-14.<\/p>\n

Depleting\u00a0the\u00a0methyltransferase\u00a0Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.
<\/a>Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z.Nat Commun<\/i>. 2013;4:1868.<\/p>\n

Na\u00efve\u00a0adult stem cells\u00a0from\u00a0patients\u00a0with\u00a0Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo.
<\/a>Wenzel V, Roedl D, Gabriel D, Gordon LB, Herlyn M, Schneider R, Ring J, Djabali K.
Biol Open<\/em>. 2012 Jun 15;1(6):516-26. Epub 2012 Apr 16<\/p>\n

Age-dependent loss of MMP-3 in Hutchinson-Gilford progeria syndrome.
<\/a>Harten IA, Zahr RS, Lemire JM, Machan JT, Moses MA, Doiron RJ, Curatolo AS, Rothman FG, Wight TN, Toole BP, Gordon LB.\u00a0J Gerontol A Biol Sci Med Sci<\/em>. 2011 Nov;66(11):1201-7.<\/p>\n

Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts.<\/a>
Cao K, Blair CD, Faddah DA, Kieckhaefer JE, Olive M, Erdos MR, Nabel EG, Collins FS.\u00a0J Clin Invest.<\/em>\u00a02011 Jul 1;121(7):2833-44<\/p>\n

Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition.<\/a>
Marji J, O\u2019Donoghue SI, McClintock D, Satagopam VP, Schneider R, Ratner D, Worman HJ, Gordon LB, Djabali K.\u00a0PLoS One<\/em>. 2010 Jun 15;5(6):e11132.<\/p>\n

Effect of progerin on the accumulation of oxidized proteins in fibroblasts from Hutchinson Gilford progeria patients.<\/a>
Viteri G, Chung YW, Stadtman ER.\u00a0Mech Ageing Dev<\/em>. 2010 Jan;131(1):2-8.<\/p>\n

Ageing-related chromatin defects through loss of the NURD complex.<\/a>
Pegoraro G, Kubben N, Wickert U, G\u00f6hler H, Hoffmann K, Misteli T.\u00a0Nat Cell Biol.<\/em>\u00a02009 Oct;11(10):1261-7.<\/p>\n

Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing.<\/a>
Scaffidi P, Misteli T.\u00a0Nat Cell Biol.\u00a0<\/em>2008 Apr;10(4):452-9.<\/p>\n

Perturbation of wild-type lamin A metabolism results in a progeroid phenotype.<\/a>
Candelario J, Sudhakar S, Navarro S, Reddy S, Comai L.\u00a0Aging Cell<\/em>. 2008 Jun;7(3):355-67<\/p>\n

Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging.<\/a>
Dechat T, Shimi T, Adam SA, Rusinol AE, Andres DA, Spielmann HP, Sinensky MS, Goldman RD.\u00a0Proc Natl Acad Sci USA<\/em>. 2007 Mar 20;104(12):4955-60.<\/p>\n

The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin.<\/a>
McClintock D, Ratner D, Lokuge M, Owens DM, Gordon LB, Collins FS, Djabali K.\u00a0PLoS One<\/em>. 2007 Dec 5;2(12):e1269.<\/p>\n

A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells.<\/a>
Cao K, Capell BC, Erdos MR, Djabali K, Collins FS.\u00a0Proc Natl Acad Sci USA<\/em>. 2007 Mar 20;104(12):4949-54.<\/p>\n

Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody.<\/a>
McClintock D, Gordon LB, Djabali K.\u00a0Proc Natl Acad Sci U S A.<\/em>\u00a02006 Feb 14;103(7):2154-9.<\/p>\n

Aggrecan expression is substantially and abnormally upregulated in Hutchinson-Gilford Progeria Syndrome dermal fibroblasts.<\/a>
Lemire JM, Patis C, Gordon LB, Sandy JD, Toole BP, Weiss AS.\u00a0Mech Ageing Dev.<\/em>\u00a02006 Aug;127(8):660-9.<\/p>\n

Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment.<\/a>
Columbaro M, Capanni C, Mattioli E, Novelli G, Parnaik VK, Squarzoni S, Maraldi NM, Lattanzi G.\u00a0Cell Mol Life Sci.<\/em>\u00a02005 Nov;62(22):2669-78.<\/p>\n

Genomic instability in laminopathy-based premature aging.<\/a>
Liu B, Wang J, Chan KM, Tjia WM, Deng W, Guan X, Huang JD, Li KM, Chau PY, Chen DJ, Pei D, Pendas AM, Cadi\u00f1anos J, L\u00f3pez-Ot\u00edn C, Tse HF, Hutchison C, Chen J, Cao Y, Cheah KS, Tryggvason K, Zhou Z.\u00a0Nat Med.<\/em>\u00a02005 Jul;11(7):780-5.<\/p>\n

Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition.<\/a>
Glynn MW, Glover TW.\u00a0Hum Mol Genet.\u00a0<\/em>2005 Oct 15;14(20):2959-69.<\/p>\n

Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome.<\/a>
Goldman RD, Shumaker DK, Erdos MR, Eriksson M, Goldman AE, Gordon LB, Gruenbaum Y, Khuon S, Mendez M, Varga R, Collins FS.\u00a0Proc Natl Acad Sci U S A<\/em>.<\/em><\/a>\u00a02004 Jun 15;101(24):8963-8.<\/p>\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>
Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS.\u00a0Nature.<\/em>\u00a02003 May 15;423(6937):293-8.<\/p>\n

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PSADFN004<\/strong><\/h4>\n

Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition.<\/a>
Glynn MW, Glover TW.\u00a0Hum Mol Genet.\u00a0<\/em>2005 Oct 15;14(20):2959-69.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN005″ module_id=”HGADFN005″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN005<\/strong>\u00a0<\/strong><\/h4>\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>
Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS.\u00a0Nature.<\/em>\u00a02003 May 15;423(6937):293-8.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN008″ module_id=”HGADFN008″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN008<\/strong>\u00a0<\/strong><\/h4>\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>
Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS.\u00a0Nature.<\/em>\u00a02003 May 15;423(6937):293-8.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN014″ module_id=”HGADFN014″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN014<\/strong>\u00a0<\/strong><\/h4>\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>
Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS.\u00a0Nature.<\/em>\u00a02003 May 15;423(6937):293-8.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGMDFN090″ module_id=”HGMDFN090″ _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGMDFN090<\/strong><\/h4>\n

Selection of specific and efficient siRNAs in new cellular model for Hutchinson-Gilford progeria syndrome therapy<\/a>
Dzianisava V, Piekarowicz K, Machowska M, Rzepecki R. Mol Ther Nucleic Acids<\/em>. 2025;36(4):102727. Published 2025 Oct 3. doi:10.1016\/j.omtn.2025.102727<\/p>\n

Transcriptional profiling of Hutchinson-Gilford Progeria patients identifies primary target pathways of progerin<\/a>
Vidak S, Kim S, Misteli T. Preprint.\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125. Published 2025 Sep 20. doi:10.1101\/2025.09.18.677125<\/p>\n

Activation of endoplasmic reticulum stress in premature aging via the inner nuclear membrane protein SUN2<\/a>
Vidak S, Serebryannyy LA, Pegoraro G, Misteli T.\u00a0Cell Rep<\/em>. 2023;42(5):112534. doi:10.1016\/j.celrep.2023.112534<\/p>\n

Unique progerin C-terminal peptide ameliorates Hutchinson-Gilford progeria syndrome phenotype by rescuing BUBR1.<\/a>
Zhang N, Hu Q, Sui T, Fu L, Zhang X, Wang Y, Zhu X, Huang B, Lu J, Li Z, Zhang Y. Nat Aging. 2023 Feb;3(2):185-201. doi: 10.1038\/s43587-023-00361-w. Epub 2023 Feb 2. Erratum in: Nat Aging. 2023 May 2;: PMID: 37118121; PMCID: PMC10154249.<\/p>\n

Quantification of Farnesylated Progerin in Hutchinson-Gilford Progeria Patient Cells by Mass Spectrometry<\/a>
Camafeita E, Jorge I, Rivera-Torres J, Andr\u00e9s V, V\u00e1zquez J. Int J Mol Sci. 2022;23(19):11733. Published 2022 Oct 3. doi:10.3390\/ijms231911733<\/p>\n

Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice<\/a>
Mojiri A, Walther BK, Jiang C, et al. [published online ahead of print, 2021 Aug 14].\u00a0Eur Heart J<\/em>. 2021;ehab547. doi:10.1093\/eurheartj\/ehab547<\/p>\n

Self-assembly of multi-component mitochondrial nucleoids via phase separation.
<\/a>Feric M, Demarest TG, Tian J, Croteau DL, Bohr VA, Misteli T. EMBO J. 2021 Mar 15;40(6):e107165. doi: 10.15252\/embj.2020107165. Epub 2021 Feb 23. PMID: 33619770; PMCID: PMC7957436.<\/p>\n

Epigenetic Deregulation of Lamina-Associated Domains in Hutchinson-Gilford Progeria Syndrome<\/a>
K\u00f6hler F, Bormann F, Raddatz G, et al. Genome Med<\/em> 2020;12(1):46. Published 2020 May 25. doi:10.1186\/s13073-020-00749-y<\/p>\n

Chromatin and Cytoskeletal Tethering Determine Nuclear Morphology in Progerin-Expressing Cells<\/a>
Lionetti MC, Bonfanti S, Fumagalli MR, Budrikis Z, Font-Clos F, Costantini G, Chepizhko O, Zapperi S, La Porta CAM. Biophysical Journal<\/em> 2020 May 5;118(9):2319-2332.<\/p>\n

Transient Introduction of Human Telomerase mRNA Improves Hallmarks of Progeria Cells<\/a>
Li Y, Zhou G, Bruno IG, et al. Aging Cell<\/em> 2019;18(4):e12979. doi:10.1111\/acel.12979<\/p>\n

A\u00a0Cell-Intrinsic\u00a0Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.
<\/a>Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S.\u00a0Cell Rep<\/em>. 2018 Feb 20;22(8):2006-2015.<\/p>\n

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies<\/a>
Horvath S, Oshima J, Martin GM, et al. Aging<\/em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632\/aging.101508<\/p>\n

Nucleoplasmic\u00a0lamins\u00a0define\u00a0growth-regulating functions of lamina-associated polypeptide 2\u03b1 in progeria cells.<\/a>\u00a0Vidak S, Georgiou K, Fichtinger P, Naetar N, Dechat T, Foisner R. J Cell Sci. 2017 Dec 28. pii: jcs.208462. doi: 10.1242\/jcs.208462. [Epub ahead of print]<\/p>\n

Progerin sequestration of PCNA promotes replication fork collapse and mislocalization of XPA in laminopathy-related progeroid syndromes<\/a>
Hilton BA, Liu J, Cartwright BM, et al. FASEB J<\/em> 2017;31(9):3882-3893. doi:10.1096\/fj.201700014R<\/p>\n

Vitamin D Receptor Signaling Improves Hutchinson-Gilford Progeria Syndrome Cellular Phenotypes<\/a>
Kreienkamp R, Croke M, Neumann MA, et al. Oncotarget<\/em> 2016;7(21):30018-30031. doi:10.18632\/oncotarget.9065<\/p>\n

Reprogramming\u00a0progeria\u00a0fibroblasts\u00a0re-establishes a normal epigenetic landscape.\u00a0<\/a>Chen Z, Chang WY, Etheridge A, Strickfaden H, Jin Z, Palidwor G, Cho JH, Wang K, Kwon SY, Dor\u00e9 C, Raymond A, Hotta A, Ellis J, Kandel RA, Dilworth FJ, Perkins TJ, Hendzel MJ, Galas DJ, Stanford WL. .Aging Cell<\/em>. 2017 Jun 8. [Epub ahead of print]<\/p>\n

Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria.
<\/a>Xiong ZM, Choi JY, Wang K, Zhang H, Tariq Z, Wu D, Ko E, LaDana C, Sesaki H, Cao K.\u00a0Aging Cell.<\/i><\/a>\u00a0 2015 Dec 14. [Epub ahead of print]<\/p>\n

Proliferation\u00a0of\u00a0progeria\u00a0cells\u00a0is\u00a0enhanced\u00a0by\u00a0lamina-associated polypeptide 2\u03b1 (LAP2\u03b1) through expression of extracellular matrix proteins.
<\/a>Vidak S, Kubben N, Dechat T, Foisner R.\u00a0Genes & Development.<\/i>\u00a02015 Oct 1;29(19):2022-36.<\/p>\n

Higher-order\u00a0unfolding\u00a0of satellite heterochromatin is a consistent and early event in cell senescence.
<\/a>Swanson EC, Manning B, Zhang H, Lawrence JB.\u00a0J Cell Biol<\/i>. 2013 Dec 23;203(6):929-42<\/p>\n

Correlated\u00a0alterations\u00a0in\u00a0genome\u00a0organization,\u00a0histone\u00a0methylation, and DNA-lamin A\/C interactions in Hutchinson-Gilford progeria syndrome.
<\/a>McCord RP, Nazario-Toole A, Zhang H, Chines PS, Zhan Y, Erdos MR, Collins FS, Dekker J, Cao K.\u00a0Genome<\/i>\u00a0Res<\/i>. 2013 Feb;23(2):260-9. Epub 2012 Nov 14.<\/p>\n

Comparison of constitutional and replication stress-induced genome structural variation by SNP array and mate-pair sequencing.<\/a>
Arlt MF, Ozdemir AC, Birkeland SR, Lyons RH Jr, Glover TW, Wilson TE.\u00a0Genetics<\/em>. 2011 Mar;187(3):675-83.<\/p>\n

Hydroxyurea induces de novo copy number variants in human cells.<\/a>
Arlt MF, Ozdemir AC, Birkeland SR, Wilson TE, Glover TW.\u00a0Proc Natl Acad Sci USA.<\/em>\u00a02011 Oct 18;108(42):17360-5<\/p>\n

Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts.<\/a>
Cao K, Blair CD, Faddah DA, Kieckhaefer JE, Olive M, Erdos MR, Nabel EG, Collins FS.\u00a0J Clin Invest.<\/em>\u00a02011 Jul 1;121(7):2833-44<\/p>\n

CTP:phosphocholine cytidylyltransferase \u03b1 (CCT\u03b1) and lamins alter nuclear membrane structure without affecting phosphatidylcholine synthesis.<\/a>
Gehrig K, Ridgway ND.\u00a0Biochim Biophys Acta<\/em>. 2011 Jun;1811(6):377-85.<\/p>\n

Effect of progerin on the accumulation of oxidized proteins in fibroblasts from Hutchinson Gilford progeria patients.<\/a>
Viteri G, Chung YW, Stadtman ER.\u00a0Mech Ageing Dev<\/em>. 2010 Jan;131(1):2-8.<\/p>\n

Replication stress induces genome-wide copy number changes in human cells that resemble polymorphic and pathogenic variants.<\/a>
Arlt MF, Mulle JG, Schaibley VM, Ragland RL, Durkin SG, Warren ST, Glover TW.\u00a0Am J Hum Genet<\/em>. 2009 Mar;84(3):339-50.<\/p>\n

A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells.<\/a>
Cao K, Capell BC, Erdos MR, Djabali K, Collins FS.\u00a0Proc Natl Acad Sci USA<\/em>. 2007 Mar 20;104(12):4949-54.<\/p>\n

Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition.<\/a>
Glynn MW, Glover TW.\u00a0Hum Mol Genet.\u00a0<\/em>2005 Oct 15;14(20):2959-69.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN122″ module_id=”HGADFN122″ _builder_version=”4.27.5″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN122<\/b><\/h4>\n

Detection of nuclear STING in cultured human cells and in the normal and cancer tissues<\/a>
Vo N, Chen E, Sidorova JM.\u00a0iScience<\/em>. 2026;29(5):115711. Published 2026 Apr 10. doi:10.1016\/j.isci.2026.115711<\/p>\n

Transcriptional profiling of Hutchinson-Gilford Progeria patients identifies primary target pathways of progerin<\/a>
Vidak S, Kim S, Misteli T. Preprint.\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125. Published 2025 Sep 20. doi:10.1101\/2025.09.18.677125<\/p>\n

Aberrant migration features in primary skin fibroblasts of Huntington’s disease patients hold potential for unraveling disease progression using an image based machine learning tool<\/a>
Gharaba S, Shalem A, Paz O, Muchtar N, Wolf L, Weil M. Comput Biol Med<\/em>. Published online August 2, 2024. doi:10.1016\/j.compbiomed.2024.108970<\/p>\n

Perturbed actin cap as a new personalized biomarker in primary fibroblasts of Huntington’s disease patients<\/a>
Gharaba S, Paz O, Feld L, Abashidze A, Weinrab M, Muchtar N, Baransi A, Shalem A, Sprecher U, Wolf L, Wolfenson H, Weil M. Front Cell Dev Biol. 2023 Jan 18;11:1013721. doi: 10.3389\/fcell.2023.1013721. PMID: 36743412; PMCID: PMC9889876.<\/p>\n

Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome<\/a>
Bersini S, Schulte R, Huang L, Tsai H, Hetzer MW. Elife<\/em>. 2020 Sep 8;9:e54383. doi: 10.7554\/eLife.54383. PMID: 32896271; PMCID: PMC7478891.<\/p>\n

Epigenetic Deregulation of Lamina-Associated Domains in Hutchinson-Gilford Progeria Syndrome<\/a>
K\u00f6hler F, Bormann F, Raddatz G, et al. Genome Med<\/em>. 2020;12(1):46. Published 2020 May 25. doi:10.1186\/s13073-020-00749-y<\/p>\n

PML2-mediated Thread-Like Nuclear Bodies Mark Late Senescence in Hutchinson-Gilford Progeria Syndrome<\/a>
Wang M, Wang L, Qian M, et al. [published online ahead of print, 2020 Apr 29]. Aging Cell
<\/em>Correction acknowledging PRF for cell lines is pending<\/strong><\/p>\n

Transient Introduction of Human Telomerase mRNA Improves Hallmarks of Progeria Cells<\/a>
Li Y, Zhou G, Bruno IG, et al. Aging Cell<\/em> 2019;18(4):e12979. doi:10.1111\/acel.12979<\/p>\n

Predicting Age From the Transcriptome of Human Dermal Fibroblasts<\/a>
Fleischer JG, Schulte R, Tsai HH, et al. Genome Biol<\/em> 2018;19(1):221. Published 2018 Dec 20. doi:10.1186\/s13059-018-1599-6<\/p>\n

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies<\/a>
Horvath S, Oshima J, Martin GM, et al. Aging<\/em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632\/aging.101508<\/p>\n

Metformin\u00a0Alleviates\u00a0Aging\u00a0Cellular\u00a0Phenotypes in Hutchinson-Gilford Progeria Syndrome Dermal Fibroblasts.<\/a>\u00a0Park SK, Shin OS.\u00a0Exp Dermatol<\/i>. 2017 Feb 13. [Epub ahead of print]Lamin A\u00a0Is an\u00a0Endogenous\u00a0SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair.<\/a>\u00a0Ghosh S, Liu B, Wang Y, Hao Q, Zhou Z.\u00a0Cell Rep<\/i>. 2015 Nov 17;13(7):1396-1406. doi: 10.1016\/j.celrep.2015.10.006. Epub 2015 Nov 5. PMID:26549451<\/p>\n

Insights\u00a0into the\u00a0role\u00a0of\u00a0immunosenescence\u00a0during varicella zoster virus infection (shingles) in the aging cell model.
<\/a>Kim JA, Park SK, Kumar M, Lee CH, Shin OS.\u00a0Oncotarget<\/i>. 2015 Oct 14. [Epub ahead of print]Depleting\u00a0the\u00a0methyltransferase\u00a0Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.
<\/a>Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z.\u00a0Nat Commun<\/i>. 2013;4:1868.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN127″ module_id=”HGADFN127″ _builder_version=”4.27.5″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN127<\/strong><\/h4>\n

Detection of nuclear STING in cultured human cells and in the normal and cancer tissues<\/a>
Vo N, Chen E, Sidorova JM.\u00a0iScience<\/em>. 2026;29(5):115711. Published 2026 Apr 10. doi:10.1016\/j.isci.2026.115711<\/p>\n

Ameliorating calcium homeostasis improves longevity and healthspan in progeroid and naturally aged mice<\/a>
Xiang W, Hu Q, Sun P, et al.\u00a0Nat Commun<\/em>. Published online June 6, 2026. doi:10.1038\/s41467-026-74021-z<\/p>\n

Transcriptional profiling of Hutchinson-Gilford Progeria patients identifies primary target pathways of progerin<\/a>
Vidak S, Kim S, Misteli T. Preprint.\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125. Published 2025 Sep 20. doi:10.1101\/2025.09.18.677125<\/p>\n

Deregulated miR-145 and miR-27b in hutchinson-gilford progeria syndrome: implications for adipogenesis<\/a>
Fenzl FQ, Lederer EM, Brumma L, et al. Aging (Albany NY)<\/em>. Published online August 27, 2025. doi:10.18632\/aging.206309<\/p>\n

Impact of miR-181a on SIRT1 Expression and Senescence in Hutchinson-Gilford Progeria Syndrome<\/a>
Lederer EM, Fenzl FQ, Kr\u00fcger P, Schroll M, Hartinger R, Djabali K. Diseases<\/em>. 2025;13(8):245. Published 2025 Aug 4. doi:10.3390\/diseases13080245<\/p>\n

Enhancing Cellular Homeostasis: Targeted Botanical Compounds Boost Cellular Health Functions in Normal and Premature Aging Fibroblasts<\/a>
Hartinger R, Singh K, Leverett J, Djabali K. Biomolecules<\/em>. 2024;14(10):1310. Published 2024 Oct 16. doi:10.3390\/biom14101310<\/p>\n

Aberrant migration features in primary skin fibroblasts of Huntington’s disease patients hold potential for unraveling disease progression using an image based machine learning tool<\/a>
Gharaba S, Shalem A, Paz O, Muchtar N, Wolf L, Weil M. Comput Biol Med<\/em>. Published online August 2, 2024. doi:10.1016\/j.compbiomed.2024.108970<\/p>\n

Activation of endoplasmic reticulum stress in premature aging via the inner nuclear membrane protein SUN2<\/a>
Vidak S, Serebryannyy LA, Pegoraro G, Misteli T.\u00a0Cell Rep<\/em>. 2023;42(5):112534. doi:10.1016\/j.celrep.2023.112534<\/p>\n

Ghrelin delays premature aging in Hutchinson-Gilford progeria syndrome<\/a>
Ferreira-Marques M, Carvalho A, Franco AC, et al. Ghrelin delays premature aging in Hutchinson-Gilford progeria syndrome [published online ahead of print, 2023 Oct 19].\u00a0Aging Cell<\/em>. 2023;e13983. doi:10.1111\/acel.13983<\/p>\n

Perturbed actin cap as a new personalized biomarker in primary fibroblasts of Huntington’s disease patients<\/a>
Gharaba S, Paz O, Feld L, Abashidze A, Weinrab M, Muchtar N, Baransi A, Shalem A, Sprecher U, Wolf L, Wolfenson H, Weil M. Front Cell Dev Biol. 2023 Jan 18;11:1013721. doi: 10.3389\/fcell.2023.1013721. PMID: 36743412; PMCID: PMC9889876.<\/p>\n

Establishment and Characterization of hTERT Immortalized Hutchinson-Gilford Progeria Fibroblast Cell Lines<\/a>
Lin H, Mensch J, Haschke M, et al. Cells. 2022;11(18):2784. Published 2022 Sep 6. doi:10.3390\/cells11182784<\/p>\n

Impact of MnTBAP and Baricitinib Treatment on Hutchinson-Gilford Progeria Fibroblasts<\/a>
Vehns E, Arnold R, Djabali K. Pharmaceuticals (Basel). 2022;15(8):945. Published 2022 Jul 29. doi:10.3390\/ph15080945<\/p>\n

SerpinE1 drives a cell-autonomous pathogenic signaling in Hutchinson-Gilford progeria syndrome<\/a>
Catarinella G, Nicoletti C, Bracaglia A, et al. Cell Death Dis. 2022;13(8):737. Published 2022 Aug 26. doi:10.1038\/s41419-022-05168-y<\/p>\n

Baricitinib, a JAK-STAT Inhibitor, Reduces the Cellular Toxicity of the Farnesyltransferase Inhibitor Lonafarnib in Progeria Cells<\/a>
Arnold R, Vehns E, Randl H, Djabali K.\u00a0Int J Mol Sci<\/em>. 2021;22(14):7474. Published 2021 Jul 12. doi:10.3390\/ijms22147474<\/p>\n

Impact of Progerin Expression on Adipogenesis in Hutchinson-Gilford Progeria Skin-Derived Precursor Cells<\/a>
Najdi F, Kr\u00fcger P, Djabali K. Cells<\/em>. 2021;10(7):1598. Published 2021 Jun 25. doi:10.3390\/cells10071598<\/p>\n

Self-assembly of multi-component mitochondrial nucleoids via phase separation.
<\/a>Feric M, Demarest TG, Tian J, Croteau DL, Bohr VA, Misteli T. EMBO J. 2021 Mar 15;40(6):e107165. doi: 10.15252\/embj.2020107165. Epub 2021 Feb 23. PMID: 33619770; PMCID: PMC7957436.<\/p>\n

Nuclear Pore Complexes Cluster in Dysmorphic Nuclei of Normal and Progeria Cells during Replicative Senescence.
<\/a>R\u00f6hrl JM, Arnold R, Djabali K. Cells. 2021 Jan 14;10(1):153. doi: 10.3390\/cells10010153. PMID: 33466669; PMCID: PMC7828780.<\/p>\n

Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome<\/a>
Bersini S, Schulte R, Huang L, Tsai H, Hetzer MW. Elife<\/em>. 2020 Sep 8;9:e54383. doi: 10.7554\/eLife.54383. PMID: 32896271; PMCID: PMC7478891.<\/p>\n

Inhibition of JAK-STAT Signaling With Baricitinib Reduces Inflammation and Improves Cellular Homeostasis in Progeria Cells<\/a>
Liu C, Arnold R, Henriques G, Djabali K. Cells<\/em> 2019;8(10):1276. Published 2019 Oct 18. doi:10.3390\/cells8101276<\/p>\n

Transient Introduction of Human Telomerase mRNA Improves Hallmarks of Progeria Cells<\/a>
Li Y, Zhou G, Bruno IG, et al. Aging Cell<\/em> 2019;18(4):e12979. doi:10.1111\/acel.12979<\/p>\n

Predicting Age From the Transcriptome of Human Dermal Fibroblasts<\/a>
Fleischer JG, Schulte R, Tsai HH, et al. Genome Biol<\/em> 2018;19(1):221. Published 2018 Dec 20. doi:10.1186\/s13059-018-1599-6<\/p>\n

Autophagic Removal of Farnesylated Carboxy-Terminal Lamin Peptides<\/a>
Lu X, Djabali K. Cells<\/em> 2018;7(4):33. Published 2018 Apr 23. doi:10.3390\/cells7040033<\/p>\n

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies<\/a>
Horvath S, Oshima J, Martin GM, et al. Aging<\/em> (Al<\/p>\n

Intermittent\u00a0treatment\u00a0with\u00a0farnesyltransferase\u00a0inhibitor\u00a0and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts.\u00a0<\/a>Gabriel D, Shafry DD, Gordon LB, Djabali K.\u00a0Oncotarget<\/em>. 2017 Jul 18;8(39):64809-64826. doi: 10.18632\/oncotarget.19363. eCollection 2017 Sep 12.<\/p>\n

Temsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular Phenotype.<\/a>
Gabriel D, Gordon LB, Djabali K. PLoS One<\/em> 2016;11(12):e0168988. Published 2016 Dec 29. doi:10.1371\/journal.pone.0168988<\/p>\n

Progerin Impairs Chromosome Maintenance by Depleting CENP-F From Metaphase Kinetochores in Hutchinson-Gilford Progeria Fibroblasts<\/a>
Eisch V, Lu X, Gabriel D, Djabali K. Oncotarget<\/em> 2016;7(17):24700-24718. doi:10.18632\/oncotarget.8267<\/p>\n

Metformin\u00a0Alleviates\u00a0Aging\u00a0Cellular\u00a0Phenotypes in Hutchinson-Gilford Progeria Syndrome Dermal Fibroblasts.<\/a>\u00a0Park SK, Shin OS.\u00a0Exp Dermatol<\/i>. 2017 Feb 13. [Epub ahead of print]<\/p>\n

Insights\u00a0into the\u00a0role\u00a0of\u00a0immunosenescence\u00a0during varicella zoster virus infection (shingles) in the aging cell model.
<\/a>Kim JA, Park SK, Kumar M, Lee CH, Shin OS.\u00a0Oncotarget<\/i>. 2015 Oct 14. [Epub ahead of print]<\/p>\n

Sulforaphane\u00a0enhances\u00a0progerin clearance in Hutchinson-Gilford progeria fibroblasts.
<\/a>Gabriel D, Roedl D, Gordon LB, Djabali K.\u00a0Aging Cell<\/i>. 2014 Dec 16: 1-14.<\/p>\n

A\u00a0proteomic\u00a0study\u00a0of\u00a0Hutchinson-Gilford progeria syndrome: Application of 2D-chromotography in a premature aging disease.
<\/a>Wang L, Yang W, Ju W, Wang P, Zhao X, Jenkins EC, Brown WT, Zhong N.\u00a0Biochem Biophys Res Commun.<\/i>\u00a02012 Jan 27;417(4):1119-26. Epub 2011 Dec 24.<\/p>\n

Age-dependent loss of MMP-3 in Hutchinson-Gilford progeria syndrome.<\/a>
Harten IA, Zahr RS, Lemire JM, Machan JT, Moses MA, Doiron RJ, Curatolo AS, Rothman FG, Wight TN, Toole BP, Gordon LB.\u00a0J Gerontol A Biol Sci Med Sci<\/em>. 2011 Nov;66(11):1201-7.
<\/strong><\/p>\n

CTP:phosphocholine cytidylyltransferase \u03b1 (CCT\u03b1) and lamins alter nuclear membrane structure without affecting phosphatidylcholine synthesis.<\/a>
Gehrig K, Ridgway ND.\u00a0Biochim Biophys Acta<\/em>. 2011 Jun;1811(6):377-85.<\/p>\n

Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition.<\/a>
Marji J, O\u2019Donoghue SI, McClintock D, Satagopam VP, Schneider R, Ratner D, Worman HJ, Gordon LB, Djabali K.\u00a0PLoS One<\/em>. 2010 Jun 15;5(6):e11132.<\/p>\n

Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: effects of farnesyltransferase inhibitors.<\/a>
Verstraeten VL, Ji JY, Cummings KS, Lee RT, Lammerding J.\u00a0Aging Cell.<\/em>\u00a02008 Jun;7(3):383-93.<\/p>\n

Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging.<\/a>
Dechat T, Shimi T, Adam SA, Rusinol AE, Andres DA, Spielmann HP, Sinensky MS, Goldman RD.\u00a0Proc Natl Acad Sci USA<\/em>. 2007 Mar 20;104(12):4955-60.<\/p>\n

The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin.<\/a>
McClintock D, Ratner D, Lokuge M, Owens DM, Gordon LB, Collins FS, Djabali K.\u00a0PLoS One<\/em>. 2007 Dec 5;2(12):e1269.<\/p>\n

Aggrecan expression is substantially and abnormally upregulated in Hutchinson-Gilford Progeria Syndrome dermal fibroblasts.<\/a>
Lemire JM, Patis C, Gordon LB, Sandy JD, Toole BP, Weiss AS.\u00a0Mech Ageing Dev<\/em>.<\/em><\/a>\u00a02006 Aug;127(8):660-9<\/p>\n

Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody.<\/a>
McClintock D, Gordon LB, Djabali K.\u00a0Proc Natl Acad Sci U S A.<\/em>\u00a02006 Feb 14;103(7):2154-9.<\/p>\n

Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment.<\/a>
Columbaro M, Capanni C, Mattioli E, Novelli G, Parnaik VK, Squarzoni S, Maraldi NM, Lattanzi G.\u00a0Cell Mol Life Sci.<\/em>\u00a02005 Nov;62(22):2669-78.<\/p>\n

Genomic instability in laminopathy-based premature aging.<\/a>
Liu B, Wang J, Chan KM, Tjia WM, Deng W, Guan X, Huang JD, Li KM, Chau PY, Chen DJ, Pei D, Pendas AM, Cadi\u00f1anos J, L\u00f3pez-Ot\u00edn C, Tse HF, Hutchison C, Chen J, Cao Y, Cheah KS, Tryggvason K, Zhou Z.\u00a0Nat Med.<\/em>\u00a02005 Jul;11(7):780-5.<\/p>\n

Novel progerin-interactive partner proteins hnRNP E1, EGF, Mel 18, and UBC9 interact with lamin A\/C.<\/a>
Zhong N, Radu G, Ju W, Brown WT. Biochem Biophys Res Commun.\u00a0<\/em>2005 Dec 16;338(2):855-61.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN136″ module_id=”HGADFN136″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN136<\/strong><\/h4>\n

Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition.<\/a>
Glynn MW, Glover TW.\u00a0Hum Mol Genet.\u00a0<\/em>2005 Oct 15;14(20):2959-69.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN143″ module_id=”HGADFN143″ _builder_version=”4.27.5″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN143<\/strong><\/h4>\n

Detection of nuclear STING in cultured human cells and in the normal and cancer tissues<\/a>
Vo N, Chen E, Sidorova JM.\u00a0iScience<\/em>. 2026;29(5):115711. Published 2026 Apr 10. doi:10.1016\/j.isci.2026.115711<\/p>\n

Transcriptional profiling of Hutchinson-Gilford Progeria patients identifies primary target pathways of progerin<\/a>
Vidak S, Kim S, Misteli T. Preprint.\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125. Published 2025 Sep 20. doi:10.1101\/2025.09.18.677125<\/p>\n

Isoprenylcysteine Carboxylmethyltransferase-Based Therapy for Hutchinson-Gilford Progeria Syndrome<\/a>
Marcos-Ramiro B, Gil-Ord\u00f3\u00f1ez A, Mar\u00edn-Ramos NI, et al. ACS Cent Sci<\/em>. 2021;7(8):1300-1310. doi:10.1021\/acscentsci.0c01698<\/p>\n

Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome<\/a>
Bersini S, Schulte R, Huang L, Tsai H, Hetzer MW. Elife<\/em>. 2020 Sep 8;9:e54383. doi: 10.7554\/eLife.54383. PMID: 32896271; PMCID: PMC7478891.<\/p>\n

Epigenetic Deregulation of Lamina-Associated Domains in Hutchinson-Gilford Progeria Syndrome<\/a>
K\u00f6hler F, Bormann F, Raddatz G, et al. Genome Med<\/em>. 2020;12(1):46. Published 2020 May 25. doi:10.1186\/s13073-020-00749-y<\/p>\n

PML2-mediated Thread-Like Nuclear Bodies Mark Late Senescence in Hutchinson-Gilford Progeria Syndrome<\/a>
Wang M, Wang L, Qian M, et al. [published online ahead of print, 2020 Apr 29]. Aging Cell<\/em>.
Correction acknowledging PRF for cell lines is pending<\/strong><\/p>\n

Transient Introduction of Human Telomerase mRNA Improves Hallmarks of Progeria Cells<\/a>
Li Y, Zhou G, Bruno IG, et al. Aging Cell<\/em> 2019;18(4):e12979. doi:10.1111\/acel.12979<\/p>\n

Predicting Age From the Transcriptome of Human Dermal Fibroblasts<\/a>
Fleischer JG, Schulte R, Tsai HH, et al. Genome Biol<\/em> 2018;19(1):221. Published 2018 Dec 20. doi:10.1186\/s13059-018-1599-6<\/p>\n

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies<\/a>
Horvath S, Oshima J, Martin GM, et al. Aging<\/em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632\/aging.101508<\/p>\n

Depleting\u00a0the\u00a0methyltransferase\u00a0Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.
<\/a>Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z.\u00a0Nat Commun<\/i>. 2013;4:1868.<\/p>\n

CTP:phosphocholine cytidylyltransferase \u03b1 (CCT\u03b1) and lamins alter nuclear membrane structure without affecting phosphatidylcholine synthesis.<\/a>
Gehrig K, Ridgway ND.\u00a0Biochim Biophys Acta.<\/em>\u00a02011 Jun;1811(6):377-85.<\/p>\n

Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: effects of farnesyltransferase inhibitors.<\/a>
Verstraeten VL, Ji JY, Cummings KS, Lee RT, Lammerding J.\u00a0Aging Cell.<\/em>\u00a02008 Jun;7(3):383-93.<\/p>\n

The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin.<\/a>
McClintock D, Ratner D, Lokuge M, Owens DM, Gordon LB, Collins FS, Djabali K.\u00a0PLoS One<\/em>. 2007 Dec 5;2(12):e1269.<\/p>\n

Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody.<\/a>
McClintock D, Gordon LB, Djabali K.\u00a0Proc Natl Acad Sci U S A.<\/em>\u00a02006 Feb 14;103(7):2154-9.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN155″ module_id=”HGADFN155″ _builder_version=”4.27.5″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN155<\/strong><\/h4>\n

Ameliorating calcium homeostasis improves longevity and healthspan in progeroid and naturally aged mice<\/a>
Xiang W, Hu Q, Sun P, et al.\u00a0Nat Commun<\/em>. Published online June 6, 2026. doi:10.1038\/s41467-026-74021-z<\/p>\n

Selection of specific and efficient siRNAs in new cellular model for Hutchinson-Gilford progeria syndrome therapy<\/a>
Dzianisava V, Piekarowicz K, Machowska M, Rzepecki R. Mol Ther Nucleic Acids<\/em>. 2025;36(4):102727. Published 2025 Oct 3. doi:10.1016\/j.omtn.2025.102727<\/p>\n

Transcriptional profiling of Hutchinson-Gilford Progeria patients identifies primary target pathways of progerin<\/a>
Vidak S, Kim S, Misteli T. Preprint.\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125. Published 2025 Sep 20. doi:10.1101\/2025.09.18.677125<\/p>\n

Angiopoietin-2 reverses endothelial cell dysfunction in progeria vasculature<\/a>
Vakili S, Izydore EK, Losert L, et al.\u00a0Aging Cell<\/em>. Published online October 18, 2024. doi:10.1111\/acel.14375<\/p>\n

The NLRP3 inhibitor Dapansutrile improves the therapeutic action of lonafarnib on progeroid mice<\/a>
Muela-Zarzuela I, Suarez-Rivero JM, Boy-Ruiz D, et al. Aging Cell<\/em>. Published online August 27, 2024. doi:10.1111\/acel.14272<\/p>\n

Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson-Gilford Progeria<\/a>
Gonz\u00e1lez-Dominguez A, Monta\u00f1ez R, Castej\u00f3n-Vega B, et al. [published online ahead of print, 2021 Aug 27].\u00a0EMBO Mol Med<\/em>. 2021;e14012. doi:10.15252\/emmm.202114012<\/p>\n

Epigenetic Deregulation of Lamina-Associated Domains in Hutchinson-Gilford Progeria Syndrome<\/a>
K\u00f6hler F, Bormann F, Raddatz G, et al. Genome Med.<\/em> 2020;12(1):46. Published 2020 May 25. doi:10.1186\/s13073-020-00749-y<\/p>\n

PML2-mediated Thread-Like Nuclear Bodies Mark Late Senescence in Hutchinson-Gilford Progeria Syndrome<\/a>
Wang M, Wang L, Qian M, et al. [published online ahead of print, 2020 Apr 29]. Aging Cell<\/em>.
Correction acknowledging PRF for cell lines is pending<\/strong><\/p>\n

Transient Introduction of Human Telomerase mRNA Improves Hallmarks of Progeria Cells<\/a>
Li Y, Zhou G, Bruno IG, et al. Aging Cell<\/em> 2019;18(4):e12979. doi:10.1111\/acel.12979<\/p>\n

Autophagic Removal of Farnesylated Carboxy-Terminal Lamin Peptides<\/a>
Lu X, Djabali K. Cells<\/em> 2018;7(4):33. Published 2018 Apr 23. doi:10.3390\/cells7040033<\/p>\n

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies<\/a>
Horvath S, Oshima J, Martin GM, et al. Aging<\/em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632\/aging.101508<\/p>\n

Nucleoplasmic\u00a0lamins\u00a0define\u00a0growth-regulating functions of lamina-associated polypeptide 2\u03b1 in progeria cells.<\/a> Vidak S, Georgiou K, Fichtinger P, Naetar N, Dechat T, Foisner R. J Cell Sci. 2017 Dec 28. pii: jcs.208462. doi: 10.1242\/jcs.208462. [Epub ahead of print]<\/p>\n

Intermittent\u00a0treatment\u00a0with\u00a0farnesyltransferase\u00a0inhibitor\u00a0and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts.\u00a0<\/a>Gabriel D, Shafry DD, Gordon LB, Djabali K.\u00a0Oncotarget<\/em>. 2017 Jul 18;8(39):64809-64826. doi: 10.18632\/oncotarget.19363. eCollection 2017 Sep 12.<\/p>\n

Temsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular Phenotype.<\/a>
Gabriel D, Gordon LB, Djabali K. PLoS One<\/em> 2016;11(12):e0168988. Published 2016 Dec 29. doi:10.1371\/journal.pone.0168988<\/p>\n

Progerin Impairs Chromosome Maintenance by Depleting CENP-F From Metaphase Kinetochores in Hutchinson-Gilford Progeria Fibroblasts<\/a>
Eisch V, Lu X, Gabriel D, Djabali K. Oncotarget<\/em> 2016;7(17):24700-24718. doi:10.18632\/oncotarget.8267<\/p>\n

Lamin A\u00a0Is an\u00a0Endogenous\u00a0SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair.<\/a>\u00a0Ghosh S, Liu B, Wang Y, Hao Q, Zhou Z.\u00a0Cell Rep<\/i>. 2015 Nov 17;13(7):1396-1406. doi: 10.1016\/j.celrep.2015.10.006. Epub 2015 Nov 5. PMID:26549451<\/p>\n

Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair.
<\/a>Ghosh S, Liu B, Wang Y, Hao Q, Zhou Z.\u00a0Cell Rep<\/i>. 2015 Nov 4. [Epub ahead of print]Proliferation\u00a0of\u00a0progeria\u00a0cells\u00a0is\u00a0enhanced\u00a0by\u00a0lamina-associated polypeptide 2\u03b1 (LAP2\u03b1) through expression of extracellular matrix proteins.
<\/a>Vidak S, Kubben N, Dechat T, Foisner R.\u00a0Genes & Development.<\/i>\u00a02015 Oct 1;29(19):2022-36.<\/p>\n

Sulforaphane\u00a0enhances\u00a0progerin clearance in Hutchinson-Gilford progeria fibroblasts.
<\/a>Gabriel D, Roedl D, Gordon LB, Djabali K.\u00a0Aging Cell<\/i>. 2014 Dec 16: 1-14.<\/p>\n

Higher-order\u00a0unfolding\u00a0of satellite heterochromatin is a consistent and early event in cell senescence.
<\/a>Swanson EC, Manning B, Zhang H, Lawrence JB.\u00a0J Cell Biol<\/i>. 2013 Dec 23;203(6):929-42.<\/p>\n

Correlated\u00a0alterations\u00a0in\u00a0genome\u00a0organization,\u00a0histone\u00a0methylation, and DNA-lamin A\/C interactions in Hutchinson-Gilford progeria syndrome.
<\/a>McCord RP, Nazario-Toole A, Zhang H, Chines PS, Zhan Y, Erdos MR, Collins FS, Dekker J, Cao K.\u00a0Genome<\/i>\u00a0Res<\/i>. 2013 Feb;23(2):260-9. Epub 2012 Nov 14.<\/p>\n

An\u00a0inhibitory\u00a0role\u00a0of\u00a0progerin\u00a0in the gene induction network of adipocyte differentiation from iPS cells.
<\/a>Xiong ZM, LaDana C, Wu D, Cao K.\u00a0Aging<\/i>\u00a0(Albany NY). 2013 Apr;5(4):288-303.<\/p>\n

Depleting\u00a0the\u00a0methyltransferase\u00a0Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.
<\/a>Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z.\u00a0Nat Commun<\/i>. 2013;4:1868.<\/p>\n

Automated\u00a0image\u00a0analysis\u00a0of\u00a0nuclear\u00a0shape: what can we\u00a0learn\u00a0from a prematurely aged cell?
<\/a>Driscoll MK, Albanese JL, Xiong ZM, Mailman M, Losert W, Cao K.\u00a0Aging<\/i>\u00a0(Albany NY). 2012 Feb;4(2):119-32.<\/p>\n

Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells.<\/a>
Cao K, Graziotto JJ, Blair CD, Mazzulli JR, Erdos MR, Krainc D, Collins FS.\u00a0Sci Transl Med.<\/em>\u00a02011 Jun 29;3(89):89ra58.<\/p>\n

Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition.<\/a>
Marji J, O\u2019Donoghue SI, McClintock D, Satagopam VP, Schneider R, Ratner D, Worman HJ, Gordon LB, Djabali K.\u00a0PLoS One<\/em>. 2010 Jun 15;5(6):e11132.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN164″ module_id=”HGADFN164″ _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN164<\/strong><\/h4>\n

Transcriptional profiling of Hutchinson-Gilford Progeria patients identifies primary target pathways of progerin<\/a>
Vidak S, Kim S, Misteli T. Preprint.\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125. Published 2025 Sep 20. doi:10.1101\/2025.09.18.677125<\/p>\n

Deregulated miR-145 and miR-27b in hutchinson-gilford progeria syndrome: implications for adipogenesis<\/a>
Fenzl FQ, Lederer EM, Brumma L, et al. Aging (Albany NY)<\/em>. Published online August 27, 2025. doi:10.18632\/aging.206309<\/p>\n

Impact of miR-181a on SIRT1 Expression and Senescence in Hutchinson-Gilford Progeria Syndrome<\/a>
Lederer EM, Fenzl FQ, Kr\u00fcger P, Schroll M, Hartinger R, Djabali K. Diseases<\/em>. 2025;13(8):245. Published 2025 Aug 4. doi:10.3390\/diseases13080245<\/p>\n

Enhancing Cellular Homeostasis: Targeted Botanical Compounds Boost Cellular Health Functions in Normal and Premature Aging Fibroblasts<\/a>
Hartinger R, Singh K, Leverett J, Djabali K. Biomolecules<\/em>. 2024;14(10):1310. Published 2024 Oct 16. doi:10.3390\/biom14101310<\/p>\n

Impact of Combined Baricitinib and FTI Treatment on Adipogenesis in Hutchinson-Gilford Progeria Syndrome and Other Lipodystrophic Laminopathies<\/a>
Hartinger R, Lederer EM, Schena E, Lattanzi G, Djabali K. Cells. 2023;12(10):1350. Published 2023 May 9. doi:10.3390\/cells12101350<\/p>\n

Establishment and Characterization of hTERT Immortalized Hutchinson-Gilford Progeria Fibroblast Cell Lines<\/a>
Lin H, Mensch J, Haschke M, et al. Cells. 2022;11(18):2784. Published 2022 Sep 6. doi:10.3390\/cells11182784<\/p>\n

SAMMY-seq reveals early alteration of heterochromatin and deregulation of bivalent genes in Hutchinson-Gilford Progeria SyndromeNat <\/a>
Sebesty\u00e9n E, Marullo F, Lucini F, Petrini C, Bianchi A, Valsoni S, Olivieri I, Antonelli L, Gregoretti F, Oliva G, Ferrari F, Lanzuolo C. Commun. 2020 Dec 8;11(1):6274. doi: 10.1038\/s41467-020-20048-9. PMID: 33293552; PMCID: PMC7722762.<\/p>\n

Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome<\/a>
Bersini S, Schulte R, Huang L, Tsai H, Hetzer MW. Elife<\/em>. 2020 Sep 8;9:e54383. doi: 10.7554\/eLife.54383. PMID: 32896271; PMCID: PMC7478891.<\/p>\n

Epigenetic Deregulation of Lamina-Associated Domains in Hutchinson-Gilford Progeria Syndrome<\/a>
K\u00f6hler F, Bormann F, Raddatz G, et al. Genome Med<\/em>. 2020;12(1):46. Published 2020 May 25. doi:10.1186\/s13073-020-00749-y<\/p>\n

Transient Introduction of Human Telomerase mRNA Improves Hallmarks of Progeria Cells<\/a>
Li Y, Zhou G, Bruno IG, et al. Aging Cell<\/em> 2019;18(4):e12979. doi:10.1111\/acel.12979<\/p>\n

Inhibition of JAK-STAT Signaling With Baricitinib Reduces Inflammation and Improves Cellular Homeostasis in Progeria Cells<\/a>
Liu C, Arnold R, Henriques G, Djabali K. Cells<\/em> 2019;8(10):1276. Published 2019 Oct 18. doi:10.3390\/cells8101276<\/p>\n

Analysis of Somatic Mutations Identifies Signs of Selection During in Vitro Aging of Primary Dermal Fibroblasts<\/a>
Narisu N, Rothwell R, Vrta\u010dnik P, et al. Aging Cell<\/em>. 2019;18(6):e13010. doi:10.1111\/acel.13010<\/p>\n

Predicting Age From the Transcriptome of Human Dermal Fibroblasts<\/a>
Fleischer JG, Schulte R, Tsai HH, et al. Genome Biol<\/em> 2018;19(1):221. Published 2018 Dec 20. doi:10.1186\/s13059-018-1599-6<\/p>\n

Diminished Canonical \u03b2-Catenin Signaling During Osteoblast Differentiation Contributes to Osteopenia in Progeria<\/a>
Choi JY, Lai JK, Xiong ZM, et al. J Bone Miner Res<\/em> 2018;33(11):2059-2070. doi:10.1002\/jbmr.3549<\/p>\n

Autophagic Removal of Farnesylated Carboxy-Terminal Lamin Peptides<\/a>
Lu X, Djabali K. Cells<\/em>. 2018;7(4):33. Published 2018 Apr 23. doi:10.3390\/cells7040033<\/p>\n

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies<\/a>
Horvath S, Oshima J, Martin GM, et al. Aging<\/em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632\/aging.101508<\/p>\n

Intermittent\u00a0treatment\u00a0with\u00a0farnesyltransferase\u00a0inhibitor\u00a0and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts.<\/a>Gabriel D, Shafry DD, Gordon LB, Djabali K.\u00a0Oncotarget<\/em>. 2017 Jul 18;8(39):64809-64826. doi: 10.18632\/oncotarget.19363. eCollection 2017 Sep 12.<\/p>\n

Temsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular Phenotype.<\/a>
Gabriel D, Gordon LB, Djabali K. PLoS One<\/em> 2016;11(12):e0168988. Published 2016 Dec 29. doi:10.1371\/journal.pone.0168988<\/p>\n

Lamin A\u00a0Is an\u00a0Endogenous\u00a0SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair.<\/a>\u00a0Ghosh S, Liu B, Wang Y, Hao Q, Zhou Z.\u00a0Cell Rep<\/i>. 2015 Nov 17;13(7):1396-1406. doi: 10.1016\/j.celrep.2015.10.006. Epub 2015 Nov 5. PMID: 26549451<\/p>\n

Sulforaphane\u00a0enhances\u00a0progerin clearance in Hutchinson-Gilford progeria fibroblasts.
<\/a>Gabriel D, Roedl D, Gordon LB, Djabali K.\u00a0Aging Cell<\/i>. 2014 Dec 16: 1-14.<\/p>\n

Mechanisms\u00a0controlling\u00a0the\u00a0smooth muscle\u00a0cell death in progeria via down-regulation of poly(ADP-ribose) polymerase 1.
<\/a>Zhang H, Xiong ZM, Cao K.\u00a0Proc Natl Acad Sci<\/i>\u00a0U S A. 2014 Jun 3;111(22):E2261-70. Epub 2014 May 19.<\/p>\n

Correlated\u00a0alterations\u00a0in\u00a0genome\u00a0organization,\u00a0histone\u00a0methylation, and DNA-lamin A\/C interactions in Hutchinson-Gilford progeria syndrome.
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An\u00a0inhibitory\u00a0role\u00a0of\u00a0progerin\u00a0in the gene induction network of adipocyte differentiation from iPS cells.
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Depleting\u00a0the\u00a0methyltransferase\u00a0Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.
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Na\u00efve\u00a0adult stem cells\u00a0from\u00a0patients\u00a0with\u00a0Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo.
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Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition.<\/a>Marji J, O\u2019Donoghue SI, McClintock D, Satagopam VP, Schneider R, Ratner D, Worman HJ, Gordon LB, Djabali K.\u00a0PLoS One<\/i>. 2010 Jun 15;5(6):e11132.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN167″ module_id=”HGADFN167″ _builder_version=”4.27.5″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN167<\/strong><\/h4>\n

Farnesylated prelamin A induces fibroblast polarity defects in premature aging disorders by inhibiting nesprin-2-SUN2 LINC complex function – PubMed<\/a>
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Ameliorating calcium homeostasis improves longevity and healthspan in progeroid and naturally aged mice<\/a>
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Increased Telomere Mobility in Progeria is Restored by Isoprenylcysteine Carboxyl Methyltransferase Inhibition<\/a>
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First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria<\/a>
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Hutchinson-Gilford progeria syndrome alters the endothelial genetic response to laminar shear stress<\/a>
Kennedy CC, Carter JL, Truskey GA.\u00a0Front Physiol<\/em>. 2026;16:1599339. Published 2026 Feb 24. doi:10.3389\/fphys.2025.1599339<\/p>\n

Generation of Nonintegrative-Induced Pluripotent Stem Cells in Hutchinson-Gilford Progeria Syndrome: Enhancing Aging Research<\/a>
Kadiwala J, Shakur R.\u00a0Aging Med (Milton)<\/em>. 2025;8(5):493-498. Published 2025 Sep 22. doi:10.1002\/agm2.70041<\/p>\n

Manipulation of the nucleoscaffold potentiates cellular reprogramming kinetics<\/a>
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A longevity-associated variant of the human BPIFB4 gene prevents diastolic dysfunction in progeria mice<\/a>
Qiu Y, Cattaneo M, Maciag A, Puca AA, Madeddu P.\u00a0Signal Transduct Target Ther<\/em>. 2025;10(1):314. Published 2025 Sep 29. doi:10.1038\/s41392-025-02416-3<\/p>\n

Transcriptional profiling of Hutchinson-Gilford Progeria patients identifies primary target pathways of progerin<\/a>
Vidak S, Kim S, Misteli T. Preprint.\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125. Published 2025 Sep 20. doi:10.1101\/2025.09.18.677125<\/p>\n

Angiopoietin-2 reverses endothelial cell dysfunction in progeria vasculature<\/a>
Vakili S, Izydore EK, Losert L, et al.\u00a0Aging Cell<\/em>. Published online October 18, 2024. doi:10.1111\/acel.14375<\/p>\n

Progerin mRNA expression in non-HGPS patients is correlated with widespread shifts in transcript isoforms<\/a>
Yu R, Xue H, Lin W, Collins FS, Mount SM, Cao K. NAR Genom Bioinform<\/em>. 2024;6(3):lqae115. Published 2024 Aug 29. doi:10.1093\/nargab\/lqae115<\/p>\n

Coaching ribosome biogenesis from the nuclear periphery<\/a>
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Activation of endoplasmic reticulum stress in premature aging via the inner nuclear membrane protein SUN2<\/a>
Vidak S, Serebryannyy LA, Pegoraro G, Misteli T.\u00a0Cell Rep<\/em>. 2023;42(5):112534. doi:10.1016\/j.celrep.2023.112534<\/p>\n

Hutchinson-Gilford progeria patient-derived cardiomyocyte model of carrying LMNA gene variant c.1824 C > T<\/a>
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Unique progerin C-terminal peptide ameliorates Hutchinson-Gilford progeria syndrome phenotype by rescuing BUBR1.<\/a>
Zhang N, Hu Q, Sui T, Fu L, Zhang X, Wang Y, Zhu X, Huang B, Lu J, Li Z, Zhang Y. Nat Aging. 2023 Feb;3(2):185-201. doi: 10.1038\/s43587-023-00361-w. Epub 2023 Feb 2. Erratum in: Nat Aging. 2023 May 2;: PMID: 37118121; PMCID: PMC10154249.<\/p>\n

Lonafarnib and everolimus reduce pathology in iPSC-derived tissue engineered blood vessel model of Hutchinson-Gilford Progeria Syndrome.<\/a>
Abutaleb NO, Atchison L, Choi L, Bedapudi A, Shores K, Gete Y, Cao K, Truskey GA. Sci Rep. 2023 Mar 28;13(1):5032. doi: 10.1038\/s41598-023-32035-3. PMID: 36977745; PMCID: PMC10050176.<\/p>\n

Transcriptional profiling of Hutchinson-Gilford Progeria syndrome fibroblasts reveals deficits in mesenchymal stem cell commitment to differentiation related to early events in endochondral ossification<\/a>
San Martin R, Das P, Sanders JT, Hill AM, McCord RP. [published online ahead of print, 2022 Dec 29].\u00a0Elife<\/em>. 2022;11:e81290. doi:10.7554\/eLife.81290<\/p>\n

Achieving single nucleotide sensitivity in direct hybridization genome imaging<\/a>
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Anti-hsa-miR-59 alleviates premature senescence associated with Hutchinson-Gilford progeria syndrome in mice<\/a>
Hu Q, Zhang N, Sui T, et al. [published online ahead of print, 2022 Nov 16].\u00a0EMBO J<\/em>. 2022;e110937. doi:10.15252\/embj.2022110937<\/p>\n

Quantification of Farnesylated Progerin in Hutchinson-Gilford Progeria Patient Cells by Mass Spectrometry<\/a>
Camafeita E, Jorge I, Rivera-Torres J, Andr\u00e9s V, V\u00e1zquez J. Int J Mol Sci. 2022;23(19):11733. Published 2022 Oct 3. doi:10.3390\/ijms231911733<\/p>\n

Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP<\/a>
La Torre M, Merigliano C, Maccaroni K, et al. J Exp Clin Cancer Res<\/em>. 2022;41(1):273. Published 2022 Sep 13. doi:10.1186\/s13046-022-02480-5<\/p>\n

SerpinE1 drives a cell-autonomous pathogenic signaling in Hutchinson-Gilford progeria syndrome<\/a>
Catarinella G, Nicoletti C, Bracaglia A, et al. Cell Death Dis. 2022;13(8):737. Published 2022 Aug 26. doi:10.1038\/s41419-022-05168-y<\/p>\n

Impaired LEF1 Activation Accelerates iPSC-Derived Keratinocytes Differentiation in Hutchinson-Gilford Progeria Syndrome<\/a>
Mao X, Xiong ZM, Xue H, et al. Int J Mol Sci. 2022;23(10):5499. Published 2022 May 14. doi:10.3390\/ijms23105499<\/p>\n

Isoprenylcysteine Carboxylmethyltransferase-Based Therapy for Hutchinson-Gilford Progeria Syndrome<\/a>
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Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice<\/a>
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Mechanisms of angiogenic incompetence in Hutchinson-Gilford progeria via downregulation of endothelial NOS.<\/a>
Gete YG, Koblan LW, Mao X, Trappio M, Mahadik B, Fisher JP, Liu DR, Cao K. Aging Cell. 2021 Jun 4:e13388. doi: 10.1111\/acel.13388. Epub ahead of print. PMID: 34086398.<\/p>\n

A targeted antisense therapeutic approach for Hutchinson-Gilford progeria syndrome
<\/a>Erdos MR, Cabral WA, Tavarez UL, Cao K, Gvozdenovic-Jeremic J, Narisu N, Zerfas PM, Crumley S, Boku Y, Hanson G, Mourich DV, Kole R, Eckhaus MA, Gordon LB, Collins FS. Nat Med. 2021 Mar;27(3):536-545. doi: 10.1038\/s41591-021-01274-0. Epub 2021 Mar 11. PMID: 33707773.<\/p>\n

In vivo base editing rescues Hutchinson-Gilford progeria syndrome in mice.
<\/a>Koblan LW, Erdos MR, Wilson C, Cabral WA, Levy JM, Xiong ZM, Tavarez UL, Davison LM, Gete YG, Mao X, Newby GA, Doherty SP, Narisu N, Sheng Q, Krilow C, Lin CY, Gordon LB, Cao K, Collins FS, Brown JD, Liu DR. Nature. 2021 Jan;589(7843):608-614. doi: 10.1038\/s41586-020-03086-7. Epub 2021 Jan 6. PMID: 33408413; PMCID: PMC7872200.<\/p>\n

Self-assembly of multi-component mitochondrial nucleoids via phase separation.
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SAMMY-seq reveals early alteration of heterochromatin and deregulation of bivalent genes in Hutchinson-Gilford Progeria SyndromeNat <\/a>
Sebesty\u00e9n E, Marullo F, Lucini F, Petrini C, Bianchi A, Valsoni S, Olivieri I, Antonelli L, Gregoretti F, Oliva G, Ferrari F, Lanzuolo C. Commun. 2020 Dec 8;11(1):6274. doi: 10.1038\/s41467-020-20048-9. PMID: 33293552; PMCID: PMC7722762.<\/p>\n

Epigenetic Deregulation of Lamina-Associated Domains in Hutchinson-Gilford Progeria Syndrome<\/a>
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iPSC-Derived Endothelial Cells Affect Vascular Function in a Tissue-Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome<\/a>
Atchison L, Abutaleb NO, Snyder-Mounts E, et al. Stem Cell Reports<\/em> 2020;14(2):325\u2010337. doi:10.1016\/j.stemcr.2020.01.005<\/p>\n

Chromatin and Cytoskeletal Tethering Determine Nuclear Morphology in Progerin-Expressing Cells<\/a>
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Phosphorylated Lamin A\/C in the Nuclear Interior Binds Active Enhancers Associated with Abnormal Transcription in Progeria<\/a>
Ikegami K, Secchia S, Almakki O, Lieb JD, Moskowitz IP. Dev Cell<\/em> 2020;52(6):699\u2010713.e11. doi:10.1016\/j.devcel.2020.02.011<\/p>\n

Peroxisomal Abnormalities and Catalase Deficiency in Hutchinson-Gilford Progeria Syndrome<\/a>
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Transient Introduction of Human Telomerase mRNA Improves Hallmarks of Progeria Cells<\/a>
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Restoring Extracellular Matrix Synthesis in Senescent Stem Cells<\/a>
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Imbalanced Nucleocytoskeletal Connections Create Common Polarity Defects in Progeria and Physiological Aging<\/a>
Chang W, Wang Y, Luxton GWG, \u00d6stlund C, Worman HJ, Gundersen GG.\u00a0 Proc Natl Acad Sci U S A<\/em> 2019;116(9):3578\u20103583. doi:10.1073\/pnas.1809683116<\/p>\n

Predicting Age From the Transcriptome of Human Dermal Fibroblasts<\/a>
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Diminished Canonical \u03b2-Catenin Signaling During Osteoblast Differentiation Contributes to Osteopenia in Progeria<\/a>
Choi JY, Lai JK, Xiong ZM, et al. J Bone Miner Res<\/em> 2018;33(11):2059-2070. doi:10.1002\/jbmr.3549<\/p>\n

Everolimus Rescues Multiple Cellular Defects in Laminopathy-Patient Fibroblasts<\/a>
DuBose AJ, Lichtenstein ST, Petrash NM, Erdos MR, Gordon LB, Collins FS [published correction appears in Proc Natl Acad Sci U S A. 2018 Apr 16;:]. Proc Natl Acad Sci U S A<\/em> 2018;115(16):4206\u20104211. doi:10.1073\/pnas.1802811115<\/p>\n

Smurf2\u00a0regulates\u00a0stability\u00a0and the autophagic-lysosomal turnover of lamin A and its disease-associated form progerin.
<\/a>Borroni AP, Emanuelli A, Shah PA, Ili\u0107 N, Apel-Sarid L, Paolini B, Manikoth Ayyathan D, Koganti P, Levy-Cohen G, Blank M.\u00a0Aging Cell<\/em>. 2018 Feb 5. doi: 10.1111\/acel.12732. [Epub ahead of print].<\/p>\n

A\u00a0Cell-Intrinsic\u00a0Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.
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Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies<\/a>
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Identification\u00a0of\u00a0novel\u00a0PDE\u03b4 interacting proteins.\u00a0<\/a>K\u00fcchler P, Zimmermann G, Winzker M, Janning P, Waldmann H, Ziegler S.\u00a0Bioorg Med Chem<\/em>. 2017 Aug 31. pii: S0968-0896(17)31182-3. doi: 10.1016\/j.bmc.2017.08.033. [Epub ahead of print]Nucleolar\u00a0expansion\u00a0and\u00a0elevated\u00a0protein\u00a0translation in premature aging.
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Reprogramming\u00a0progeria\u00a0fibroblasts\u00a0re-establishes a normal epigenetic landscape.\u00a0<\/a>Chen Z, Chang WY, Etheridge A, Strickfaden H, Jin Z, Palidwor G, Cho JH, Wang K, Kwon SY, Dor\u00e9 C, Raymond A, Hotta A, Ellis J, Kandel RA, Dilworth FJ, Perkins TJ, Hendzel MJ, Galas DJ, Stanford WL. .Aging Cell<\/em>. 2017 Jun 8. [Epub ahead of print]Metformin\u00a0Alleviates\u00a0Aging\u00a0Cellular\u00a0Phenotypes in Hutchinson-Gilford Progeria Syndrome Dermal Fibroblasts.<\/a>
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NANOG\u00a0reverses\u00a0the\u00a0Myogenic\u00a0Differentiation Potential of Senescent Stem Cells by Restoring ACTIN Filamentous Organization and SRF-Dependent Gene Expression.\u00a0<\/a>Mistriotis P, Bajpai VK, Wang X, Rong N, Shahini A, Asmani M, Liang MS, Wang J, Lei P, Liu S, Zhao R, Andreadis ST.\u00a0Stem Cells<\/em>. 2016 Jun 28. doi: 10.1002\/stem.2452. [Epub ahead of print]<\/p>\n

Vitamin D Receptor Signaling Improves Hutchinson-Gilford Progeria Syndrome Cellular Phenotypes<\/a>
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Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria.
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Insights\u00a0into the\u00a0role\u00a0of\u00a0immunosenescence\u00a0during varicella zoster virus infection (shingles) in the aging cell model.
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Proliferation\u00a0of\u00a0progeria\u00a0cells\u00a0is\u00a0enhanced\u00a0by\u00a0lamina-associated polypeptide 2\u03b1 (LAP2\u03b1) through expression of extracellular matrix proteins.
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Nuclear\u00a0stiffening\u00a0and\u00a0chromatin\u00a0softening with progerin expression leads to an attenuated nuclear\u00a0response to force.
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Phenotype-Dependent\u00a0Coexpression\u00a0Gene\u00a0Clusters: Application to Normal and Premature Ageing.
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Mechanisms\u00a0controlling\u00a0the\u00a0smooth muscle\u00a0cell death in progeria via down-regulation of poly(ADP-ribose) polymerase 1.
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Higher-order\u00a0unfolding\u00a0of satellite heterochromatin is a consistent and early event in cell senescence.
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Correlated\u00a0alterations\u00a0in\u00a0genome\u00a0organization,\u00a0histone\u00a0methylation, and DNA-lamin A\/C interactions in Hutchinson-Gilford progeria syndrome.
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Progeria:\u00a0translational\u00a0insights\u00a0from\u00a0cell biology.
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Automated\u00a0image\u00a0analysis\u00a0of\u00a0nuclear\u00a0shape: what can we\u00a0learn\u00a0from a prematurely aged cell?
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Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders.<\/a>Choi\u00a0S,\u00a0Wang\u00a0W,\u00a0Ribeiro\u00a0AJ, Kalinowski A, Gregg SQ, Opresko PL, Niedernhofer LJ, Rohde GK, Dahl KN.\u00a0Nucleus<\/i>. 2011 Nov 1;2(6):570-9. Epub 2011 Nov 1.<\/p>\n

Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells.<\/a>
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Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts.<\/a>
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CTP:phosphocholine cytidylyltransferase \u03b1 (CCT\u03b1) and lamins alter nuclear membrane structure without affecting phosphatidylcholine synthesis.<\/a>
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Effect of progerin on the accumulation of oxidized proteins in fibroblasts from Hutchinson Gilford progeria patients.<\/a>
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A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells.<\/a>
Cao K, Capell BC, Erdos MR, Djabali K, Collins FS.\u00a0Proc Natl Acad Sci USA<\/em>. 2007 Mar 20;104(12):4949-54.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGFDFN168″ module_id=”HGFDFN168″ _builder_version=”4.27.5″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGFDFN168<\/strong><\/h4>\n

Farnesylated prelamin A induces fibroblast polarity defects in premature aging disorders by inhibiting nesprin-2-SUN2 LINC complex function – PubMed<\/a>
Lio C, Wang Y, Wilson PC, et al. J Cell Sci<\/em>. 2026;139(12):jcs264488. doi:10.1242\/jcs.264488<\/p>\n

Increased Telomere Mobility in Progeria is Restored by Isoprenylcysteine Carboxyl Methyltransferase Inhibition<\/a>
Gagliano G, Raterink A, Yang X, Berg\u00f6 M, Gustavsson AK. Preprint.\u00a0bioRxiv<\/em>. 2026;2026.04.25.720781. Published 2026 Apr 28. doi:10.64898\/2026.04.25.720781<\/p>\n

First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria<\/a>
Macicior-Michelena J, Telechea M, Fern\u00e1ndez D, Garc\u00eda-Mart\u00edn A, Canales \u00c1, Ortega-Guti\u00e9rrez S.\u00a0Adv Sci (Weinh)<\/em>. Published online March 23, 2026. doi:10.1002\/advs.202521608<\/p>\n

Hutchinson-Gilford progeria syndrome alters the endothelial genetic response to laminar shear stress<\/a>
Kennedy CC, Carter JL, Truskey GA.\u00a0Front Physiol<\/em>. 2026;16:1599339. Published 2026 Feb 24. doi:10.3389\/fphys.2025.1599339<\/p>\n

Manipulation of the nucleoscaffold potentiates cellular reprogramming kinetics<\/a>
Yang BA, Vesga-Castro C, Monteiro da Rocha A, et al. PNAS Nexus<\/em>. 2025;4(10):pgaf307. Published 2025 Sep 25. doi:10.1093\/pnasnexus\/pgaf307<\/p>\n

A longevity-associated variant of the human BPIFB4 gene prevents diastolic dysfunction in progeria mice<\/a>
Qiu Y, Cattaneo M, Maciag A, Puca AA, Madeddu P.\u00a0Signal Transduct Target Ther<\/em>. 2025;10(1):314. Published 2025 Sep 29. doi:10.1038\/s41392-025-02416-3<\/p>\n

Transcriptional profiling of Hutchinson-Gilford Progeria patients identifies primary target pathways of progerin<\/a>
Vidak S, Kim S, Misteli T. Preprint.\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125. Published 2025 Sep 20. doi:10.1101\/2025.09.18.677125<\/p>\n

Angiopoietin-2 reverses endothelial cell dysfunction in progeria vasculature<\/a>
Vakili S, Izydore EK, Losert L, et al.\u00a0Aging Cell<\/em>. Published online October 18, 2024. doi:10.1111\/acel.14375<\/p>\n

Progerin mRNA expression in non-HGPS patients is correlated with widespread shifts in transcript isoforms<\/a>
Yu R, Xue H, Lin W, Collins FS, Mount SM, Cao K. NAR Genom Bioinform<\/em>. 2024;6(3):lqae115. Published 2024 Aug 29. doi:10.1093\/nargab\/lqae115<\/p>\n

Activation of endoplasmic reticulum stress in premature aging via the inner nuclear membrane protein SUN2<\/a>
Vidak S, Serebryannyy LA, Pegoraro G, Misteli T.\u00a0Cell Rep<\/em>. 2023;42(5):112534. doi:10.1016\/j.celrep.2023.112534<\/p>\n

Hutchinson-Gilford progeria patient-derived cardiomyocyte model of carrying LMNA gene variant c.1824 C > T<\/a>
Perales S, Sigamani V, Rajasingh S, Czirok A, Rajasingh J. [published online ahead of print, 2023 Aug 12].\u00a0Cell Tissue Res<\/em>. 2023;10.1007\/s00441-023-03813-2. doi:10.1007\/s00441-023-03813-2<\/p>\n

Unique progerin C-terminal peptide ameliorates Hutchinson-Gilford progeria syndrome phenotype by rescuing BUBR1.<\/a>
Zhang N, Hu Q, Sui T, Fu L, Zhang X, Wang Y, Zhu X, Huang B, Lu J, Li Z, Zhang Y. Nat Aging. 2023 Feb;3(2):185-201. doi: 10.1038\/s43587-023-00361-w. Epub 2023 Feb 2. Erratum in: Nat Aging. 2023 May 2;: PMID: 37118121; PMCID: PMC10154249.<\/p>\n

Lonafarnib and everolimus reduce pathology in iPSC-derived tissue engineered blood vessel model of Hutchinson-Gilford Progeria Syndrome.<\/a>
Abutaleb NO, Atchison L, Choi L, Bedapudi A, Shores K, Gete Y, Cao K, Truskey GA. Sci Rep. 2023 Mar 28;13(1):5032. doi: 10.1038\/s41598-023-32035-3. PMID: 36977745; PMCID: PMC10050176.<\/p>\n

Transcriptional profiling of Hutchinson-Gilford Progeria syndrome fibroblasts reveals deficits in mesenchymal stem cell commitment to differentiation related to early events in endochondral ossification<\/a>
San Martin R, Das P, Sanders JT, Hill AM, McCord RP. [published online ahead of print, 2022 Dec 29].\u00a0Elife<\/em>. 2022;11:e81290. doi:10.7554\/eLife.81290<\/p>\n

Quantification of Farnesylated Progerin in Hutchinson-Gilford Progeria Patient Cells by Mass Spectrometry<\/a>
Camafeita E, Jorge I, Rivera-Torres J, Andr\u00e9s V, V\u00e1zquez J. Int J Mol Sci. 2022;23(19):11733. Published 2022 Oct 3. doi:10.3390\/ijms231911733<\/p>\n

Impaired LEF1 Activation Accelerates iPSC-Derived Keratinocytes Differentiation in Hutchinson-Gilford Progeria Syndrome<\/a>
Mao X, Xiong ZM, Xue H, et al. Int J Mol Sci. 2022;23(10):5499. Published 2022 May 14. doi:10.3390\/ijms23105499<\/p>\n

Isoprenylcysteine Carboxylmethyltransferase-Based Therapy for Hutchinson-Gilford Progeria Syndrome<\/a>
Marcos-Ramiro B, Gil-Ord\u00f3\u00f1ez A, Mar\u00edn-Ramos NI, et al. ACS Cent Sci<\/em>. 2021;7(8):1300-1310. doi:10.1021\/acscentsci.0c01698<\/p>\n

Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice<\/a>
Mojiri A, Walther BK, Jiang C, et al. [published online ahead of print, 2021 Aug 14].\u00a0Eur Heart J<\/em>. 2021;ehab547. doi:10.1093\/eurheartj\/ehab547<\/p>\n

Mechanisms of angiogenic incompetence in Hutchinson-Gilford progeria via downregulation of endothelial NOS.<\/a>
Gete YG, Koblan LW, Mao X, Trappio M, Mahadik B, Fisher JP, Liu DR, Cao K. Aging Cell. 2021 Jun 4:e13388. doi: 10.1111\/acel.13388. Epub ahead of print. PMID: 34086398.<\/p>\n

A targeted antisense therapeutic approach for Hutchinson-Gilford progeria syndrome
<\/a>Erdos MR, Cabral WA, Tavarez UL, Cao K, Gvozdenovic-Jeremic J, Narisu N, Zerfas PM, Crumley S, Boku Y, Hanson G, Mourich DV, Kole R, Eckhaus MA, Gordon LB, Collins FS. Nat Med. 2021 Mar;27(3):536-545. doi: 10.1038\/s41591-021-01274-0. Epub 2021 Mar 11. PMID: 33707773.<\/p>\n

In vivo base editing rescues Hutchinson-Gilford progeria syndrome in mice.
<\/a>Koblan LW, Erdos MR, Wilson C, Cabral WA, Levy JM, Xiong ZM, Tavarez UL, Davison LM, Gete YG, Mao X, Newby GA, Doherty SP, Narisu N, Sheng Q, Krilow C, Lin CY, Gordon LB, Cao K, Collins FS, Brown JD, Liu DR. Nature. 2021 Jan;589(7843):608-614. doi: 10.1038\/s41586-020-03086-7. Epub 2021 Jan 6. PMID: 33408413; PMCID: PMC7872200.<\/p>\n

Self-assembly of multi-component mitochondrial nucleoids via phase separation.
<\/a>Feric M, Demarest TG, Tian J, Croteau DL, Bohr VA, Misteli T. EMBO J. 2021 Mar 15;40(6):e107165. doi: 10.15252\/embj.2020107165. Epub 2021 Feb 23. PMID: 33619770; PMCID: PMC7957436.<\/p>\n

Epigenetic Deregulation of Lamina-Associated Domains in Hutchinson-Gilford Progeria Syndrome<\/a>
K\u00f6hler F, Bormann F, Raddatz G, et al. Genome Med<\/em>. 2020;12(1):46. Published 2020 May 25. doi:10.1186\/s13073-020-00749-y<\/p>\n

Peroxisomal Abnormalities and Catalase Deficiency in Hutchinson-Gilford Progeria Syndrome<\/a>
Mao X, Bharti P, Thaivalappil A, Cao K. Aging<\/em> (Albany NY) 2020;12(6):5195\u20105208. doi:10.18632\/aging.102941<\/p>\n

iPSC-Derived Endothelial Cells Affect Vascular Function in a Tissue-Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome<\/a>Atchison L, Abutaleb NO, Snyder-Mounts E, et al. Stem Cell Reports<\/em> 2020;14(2):325\u2010337. doi:10.1016\/j.stemcr.2020.01.005<\/p>\n

Restoring Extracellular Matrix Synthesis in Senescent Stem Cells<\/a>
Rong N, Mistriotis P, Wang X, et al. FASEB J<\/em>. 2019;33(10):10954\u201010965. doi:10.1096\/fj.201900377R<\/p>\n

Imbalanced Nucleocytoskeletal Connections Create Common Polarity Defects in Progeria and Physiological Aging<\/a>
Chang W, Wang Y, Luxton GWG, \u00d6stlund C, Worman HJ, Gundersen GG.\u00a0 Proc Natl Acad Sci U S A<\/em> 2019;116(9):3578\u20103583. doi:10.1073\/pnas.1809683116<\/p>\n

Diminished Canonical \u03b2-Catenin Signaling During Osteoblast Differentiation Contributes to Osteopenia in Progeria<\/a>
Choi JY, Lai JK, Xiong ZM, et al. J Bone Miner Res<\/em> 2018;33(11):2059-2070. doi:10.1002\/jbmr.3549<\/p>\n

Everolimus Rescues Multiple Cellular Defects in Laminopathy-Patient Fibroblasts<\/a>
DuBose AJ, Lichtenstein ST, Petrash NM, Erdos MR, Gordon LB, Collins FS [published correction appears in Proc Natl Acad Sci U S A 2018 Apr 16;:]. Proc Natl Acad Sci U S A<\/em>. 2018;115(16):4206\u20104211. doi:10.1073\/pnas.1802811115<\/p>\n

Smurf2\u00a0regulates\u00a0stability\u00a0and the autophagic-lysosomal turnover of lamin A and its disease-associated form progerin.
<\/a>Borroni AP, Emanuelli A, Shah PA, Ili\u0107 N, Apel-Sarid L, Paolini B, Manikoth Ayyathan D, Koganti P, Levy-Cohen G, Blank M.\u00a0Aging Cell<\/em>. 2018 Feb 5. doi: 10.1111\/acel.12732. [Epub ahead of print].<\/p>\n

Nucleoplasmic\u00a0lamins\u00a0define\u00a0growth-regulating functions of lamina-associated polypeptide 2\u03b1 in progeria cells.<\/a>\u00a0Vidak S, Georgiou K, Fichtinger P, Naetar N, Dechat T, Foisner R. J Cell Sci. 2017 Dec 28. pii: jcs.208462. doi: 10.1242\/jcs.208462. [Epub ahead of print]Nucleolar\u00a0expansion\u00a0and\u00a0elevated\u00a0protein\u00a0translation in premature aging.<\/a>\u00a0Buchwalter A, Hetzer MW. Nat Commun. 2017 Aug 30;8(1):328. doi: 10.1038\/s41467-017-00322-z.<\/p>\n

Reprogramming\u00a0progeria\u00a0fibroblasts\u00a0re-establishes a normal epigenetic landscape.\u00a0<\/a>Chen Z, Chang WY, Etheridge A, Strickfaden H, Jin Z, Palidwor G, Cho JH, Wang K, Kwon SY, Dor\u00e9 C, Raymond A, Hotta A, Ellis J, Kandel RA, Dilworth FJ, Perkins TJ, Hendzel MJ, Galas DJ, Stanford WL. .Aging Cell<\/em>. 2017 Jun 8. [Epub ahead of print]<\/p>\n

Loss\u00a0of\u00a0H3K9me3\u00a0Correlates with ATM Activation and Histone H2AX Phosphorylation Deficiencies in Hutchinson-Gilford Progeria Syndrome.<\/a>\u00a0Zhang H, Sun L, Wang K, Wu D, Trappio M, Witting C, Cao K.\u00a0PLoS One<\/em>. 2016 Dec 1;11(12):e0167454. doi: 10.1371\/journal.pone.0167454.<\/p>\n

NANOG\u00a0reverses\u00a0the\u00a0Myogenic\u00a0Differentiation Potential of Senescent Stem Cells by Restoring ACTIN Filamentous Organization and SRF-Dependent Gene Expression.<\/a>Mistriotis P, Bajpai VK, Wang X, Rong N, Shahini A, Asmani M, Liang MS, Wang J, Lei P, Liu S, Zhao R, Andreadis ST.\u00a0Stem Cells<\/em>. 2016 Jun 28. doi: 10.1002\/stem.2452. [Epub ahead of print]<\/p>\n

Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria.
<\/a>Xiong ZM, Choi JY, Wang K, Zhang H, Tariq Z, Wu D, Ko E, LaDana C, Sesaki H, Cao K.\u00a0Aging Cell.<\/i><\/a>\u00a0 2015 Dec 14. [Epub ahead of print]<\/p>\n

Proliferation\u00a0of\u00a0progeria\u00a0cells\u00a0is\u00a0enhanced\u00a0by\u00a0lamina-associated polypeptide 2\u03b1 (LAP2\u03b1) through expression of extracellular matrix proteins.
<\/a>Vidak S, Kubben N, Dechat T, Foisner R.\u00a0Genes & Development.<\/i>\u00a02015 Oct 1;29(19):2022-36.<\/p>\n

Nuclear\u00a0stiffening\u00a0and\u00a0chromatin\u00a0softening with progerin expression leads to an attenuated nuclear\u00a0response to force.
<\/a>Booth EA, Spagnol ST, Alcoser TA, Dahl KN.\u00a0Soft Matter<\/i>. 2015 Aug 28;11(32):6412-8. Epub 2015 Jul 14.<\/p>\n

Phenotype-Dependent\u00a0Coexpression\u00a0Gene\u00a0Clusters: Application to Normal and Premature Ageing.
<\/a>Wang K, Das A, Xiong Z,\u00a0 Cao K, Hannenhalli S.\u00a0IEEE\/ACM Trans Comput Biol Bioinform<\/i>\u00a02015 Jan-Feb;12(1):30-9.<\/p>\n

Mechanisms\u00a0controlling\u00a0the\u00a0smooth muscle\u00a0cell death in progeria via down-regulation of poly(ADP-ribose) polymerase 1.
<\/a>Zhang H, Xiong ZM, Cao K.\u00a0Proc Natl Acad Sci<\/i>\u00a0U S A. 2014 Jun 3;111(22):E2261-70. Epub 2014 May 19.<\/p>\n

Correlated\u00a0alterations\u00a0in\u00a0genome\u00a0organization,\u00a0histone\u00a0methylation, and DNA-lamin A\/C interactions in Hutchinson-Gilford progeria syndrome.
<\/a>McCord RP, Nazario-Toole A, Zhang H, Chines PS, Zhan Y, Erdos MR, Collins FS, Dekker J, Cao K.\u00a0Genome<\/i>\u00a0Res<\/i>. 2013 Feb;23(2):260-9. Epub 2012 Nov 14.<\/p>\n

Automated\u00a0image\u00a0analysis\u00a0of\u00a0nuclear\u00a0shape: what can we\u00a0learn\u00a0from a prematurely aged cell?
<\/a>Driscoll MK, Albanese JL, Xiong ZM, Mailman M, Losert W, Cao K.\u00a0Aging<\/i>\u00a0(Albany NY). 2012 Feb;4(2):119-32.<\/p>\n

Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders.
<\/a>Choi\u00a0S,\u00a0Wang\u00a0W,\u00a0Ribeiro\u00a0AJ, Kalinowski A, Gregg SQ, Opresko PL, Niedernhofer LJ, Rohde GK, Dahl KN.\u00a0Nucleus<\/i>. 2011 Nov 1;2(6):570-9. Epub 2011 Nov 1.<\/p>\n

Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells.<\/a>
Cao K, Graziotto JJ, Blair CD, Mazzulli JR, Erdos MR, Krainc D, Collins FS.\u00a0Sci Transl Med.<\/em>\u00a02011 Jun 29;3(89):89ra58.<\/p>\n

Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts.<\/a>
Cao K, Blair CD, Faddah DA, Kieckhaefer JE, Olive M, Erdos MR, Nabel EG, Collins FS.\u00a0J Clin Invest<\/em>.<\/em>\u00a02011 Jul 1;121(7):2833-44<\/p>\n

Effect of progerin on the accumulation of oxidized proteins in fibroblasts from Hutchinson Gilford progeria patients.<\/a>
Viteri G, Chung YW, Stadtman ER.\u00a0Mech Ageing Dev<\/em>. 2010 Jan;131(1):2-8.<\/p>\n

A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells.<\/a>
Cao K, Capell BC, Erdos MR, Djabali K, Collins FS.\u00a0Proc Natl Acad Sci USA<\/em>. 2007 Mar 20;104(12):4949-54.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN169″ module_id=”HGADFN169″ _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN169<\/strong><\/h4>\n

A longevity-associated variant of the human BPIFB4 gene prevents diastolic dysfunction in progeria mice<\/a>
Qiu Y, Cattaneo M, Maciag A, Puca AA, Madeddu P.\u00a0Signal Transduct Target Ther<\/em>. 2025;10(1):314. Published 2025 Sep 29. doi:10.1038\/s41392-025-02416-3<\/p>\n

Transcriptional profiling of Hutchinson-Gilford Progeria patients identifies primary target pathways of progerin<\/a>
Vidak S, Kim S, Misteli T. Preprint.\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125. Published 2025 Sep 20. doi:10.1101\/2025.09.18.677125<\/p>\n

Aberrant migration features in primary skin fibroblasts of Huntington’s disease patients hold potential for unraveling disease progression using an image based machine learning tool<\/a>
Gharaba S, Shalem A, Paz O, Muchtar N, Wolf L, Weil M. Comput Biol Med<\/em>. Published online August 2, 2024. doi:10.1016\/j.compbiomed.2024.108970<\/p>\n

Perturbed actin cap as a new personalized biomarker in primary fibroblasts of Huntington’s disease patients<\/a>
Gharaba S, Paz O, Feld L, Abashidze A, Weinrab M, Muchtar N, Baransi A, Shalem A, Sprecher U, Wolf L, Wolfenson H, Weil M. Front Cell Dev Biol. 2023 Jan 18;11:1013721. doi: 10.3389\/fcell.2023.1013721. PMID: 36743412; PMCID: PMC9889876.<\/p>\n

SerpinE1 drives a cell-autonomous pathogenic signaling in Hutchinson-Gilford progeria syndrome<\/a>
Catarinella G, Nicoletti C, Bracaglia A, et al. Cell Death Dis. 2022;13(8):737. Published 2022 Aug 26. doi:10.1038\/s41419-022-05168-y<\/p>\n

SAMMY-seq reveals early alteration of heterochromatin and deregulation of bivalent genes in Hutchinson-Gilford Progeria SyndromeNat <\/a>
Sebesty\u00e9n E, Marullo F, Lucini F, Petrini C, Bianchi A, Valsoni S, Olivieri I, Antonelli L, Gregoretti F, Oliva G, Ferrari F, Lanzuolo C. Commun. 2020 Dec 8;11(1):6274. doi: 10.1038\/s41467-020-20048-9. PMID: 33293552; PMCID: PMC7722762.<\/p>\n

Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome<\/a>
Bersini S, Schulte R, Huang L, Tsai H, Hetzer MW. Elife<\/em>. 2020 Sep 8;9:e54383. doi: 10.7554\/eLife.54383. PMID: 32896271; PMCID: PMC7478891.<\/p>\n

Epigenetic Deregulation of Lamina-Associated Domains in Hutchinson-Gilford Progeria Syndrome<\/a>
K\u00f6hler F, Bormann F, Raddatz G, et al. Genome Med<\/em>. 2020;12(1):46. Published 2020 May 25. doi:10.1186\/s13073-020-00749-y<\/p>\n

PML2-mediated Thread-Like Nuclear Bodies Mark Late Senescence in Hutchinson-Gilford Progeria Syndrome<\/a>
Wang M, Wang L, Qian M, et al. [published online ahead of print, 2020 Apr 29]. Aging Cell<\/em>.
Correction acknowledging PRF for cell lines is pending<\/strong><\/p>\n

Transient Introduction of Human Telomerase mRNA Improves Hallmarks of Progeria Cells<\/a>
Li Y, Zhou G, Bruno IG, et al. Aging Cell<\/em> 2019;18(4):e12979. doi:10.1111\/acel.12979<\/p>\n

Predicting Age From the Transcriptome of Human Dermal Fibroblasts<\/a>
Fleischer JG, Schulte R, Tsai HH, et al. Genome Biol<\/em> 2018;19(1):221. Published 2018 Dec 20. doi:10.1186\/s13059-018-1599-6<\/p>\n

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies<\/a>
Horvath S, Oshima J, Martin GM, et al. Aging<\/em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632\/aging.101508<\/p>\n

Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria.
<\/a>Xiong ZM, Choi JY, Wang K, Zhang H, Tariq Z, Wu D, Ko E, LaDana C, Sesaki H, Cao K.\u00a0Aging Cell.<\/i><\/a>\u00a0 2015 Dec 14. [Epub ahead of print]<\/p>\n

Lamin A\u00a0Is an\u00a0Endogenous\u00a0SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair.<\/a>\u00a0Ghosh S, Liu B, Wang Y, Hao Q, Zhou Z.\u00a0Cell Rep<\/i>. 2015 Nov 17;13(7):1396-1406. doi: 10.1016\/j.celrep.2015.10.006. Epub 2015 Nov 5. PMID:26549451<\/p>\n

Correlated\u00a0alterations\u00a0in\u00a0genome\u00a0organization,\u00a0histone\u00a0methylation, and DNA-lamin A\/C interactions in Hutchinson-Gilford progeria syndrome.
<\/a>McCord RP, Nazario-Toole A, Zhang H, Chines PS, Zhan Y, Erdos MR, Collins FS, Dekker J, Cao K.\u00a0Genome<\/i>\u00a0Res<\/i>. 2013 Feb;23(2):260-9. Epub 2012 Nov 14.<\/p>\n

Depleting\u00a0the\u00a0methyltransferase\u00a0Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.
<\/a>Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z.\u00a0Nat Commun<\/i>. 2013;4:1868.<\/p>\n

Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells.
<\/a>[sta_anchor id=\u201dfn178\u2033 unsan=\u201dFN178\u2033]Cao K, Graziotto JJ, Blair CD, Mazzulli JR, Erdos MR, Krainc D, Collins FS.\u00a0Sci Transl Med.<\/i>\u00a02011 Jun 29;3(89):89ra58.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN178″ module_id=”HGADFN178″ _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN178<\/b><\/h4>\n

Transcriptional profiling of Hutchinson-Gilford Progeria patients identifies primary target pathways of progerin<\/a>
Vidak S, Kim S, Misteli T. Preprint.\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125. Published 2025 Sep 20. doi:10.1101\/2025.09.18.677125<\/p>\n

Deregulated miR-145 and miR-27b in hutchinson-gilford progeria syndrome: implications for adipogenesis<\/a>
Fenzl FQ, Lederer EM, Brumma L, et al. Aging (Albany NY)<\/em>. Published online August 27, 2025. doi:10.18632\/aging.206309<\/p>\n

Impact of miR-181a on SIRT1 Expression and Senescence in Hutchinson-Gilford Progeria Syndrome<\/a>
Lederer EM, Fenzl FQ, Kr\u00fcger P, Schroll M, Hartinger R, Djabali K. Diseases<\/em>. 2025;13(8):245. Published 2025 Aug 4. doi:10.3390\/diseases13080245<\/p>\n

Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models<\/a>
Zonari A, Brace LE, Al-Katib K, et al. 2024 Feb 15;10(1):14].\u00a0NPJ Aging<\/em>. 2023;9(1):10. Published 2023 May 22. doi:10.1038\/s41514-023-00109-1<\/p>\n

Activation of endoplasmic reticulum stress in premature aging via the inner nuclear membrane protein SUN2<\/a>
Vidak S, Serebryannyy LA, Pegoraro G, Misteli T.\u00a0Cell Rep<\/em>. 2023;42(5):112534. doi:10.1016\/j.celrep.2023.112534<\/p>\n

Impact of Combined Baricitinib and FTI Treatment on Adipogenesis in Hutchinson-Gilford Progeria Syndrome and Other Lipodystrophic Laminopathies<\/a>
Hartinger R, Lederer EM, Schena E, Lattanzi G, Djabali K. Cells. 2023;12(10):1350. Published 2023 May 9. doi:10.3390\/cells12101350<\/p>\n

Establishment and Characterization of hTERT Immortalized Hutchinson-Gilford Progeria Fibroblast Cell Lines<\/a>
Lin H, Mensch J, Haschke M, et al. Cells. 2022;11(18):2784. Published 2022 Sep 6. doi:10.3390\/cells11182784<\/p>\n

Quantification of Farnesylated Progerin in Hutchinson-Gilford Progeria Patient Cells by Mass Spectrometry<\/a>
Camafeita E, Jorge I, Rivera-Torres J, Andr\u00e9s V, V\u00e1zquez J. Int J Mol Sci. 2022;23(19):11733. Published 2022 Oct 3. doi:10.3390\/ijms231911733<\/p>\n

Self-assembly of multi-component mitochondrial nucleoids via phase separation.
<\/a>Feric M, Demarest TG, Tian J, Croteau DL, Bohr VA, Misteli T. EMBO J. 2021 Mar 15;40(6):e107165. doi: 10.15252\/embj.2020107165. Epub 2021 Feb 23. PMID: 33619770; PMCID: PMC7957436.<\/p>\n

Nuclear Pore Complexes Cluster in Dysmorphic Nuclei of Normal and Progeria Cells during Replicative Senescence.
<\/a>R\u00f6hrl JM, Arnold R, Djabali K. Cells. 2021 Jan 14;10(1):153. doi: 10.3390\/cells10010153. PMID: 33466669; PMCID: PMC7828780.<\/p>\n

Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome<\/a>
Bersini S, Schulte R, Huang L, Tsai H, Hetzer MW. Elife<\/em>. 2020 Sep 8;9:e54383. doi: 10.7554\/eLife.54383. PMID: 32896271; PMCID: PMC7478891.<\/p>\n

Epigenetic Deregulation of Lamina-Associated Domains in Hutchinson-Gilford Progeria Syndrome<\/a>
K\u00f6hler F, Bormann F, Raddatz G, et al. Genome Med<\/em>. 2020;12(1):46. Published 2020 May 25. doi:10.1186\/s13073-020-00749-y<\/p>\n

Transient Introduction of Human Telomerase mRNA Improves Hallmarks of Progeria Cells<\/a>
Li Y, Zhou G, Bruno IG, et al. Aging Cell<\/em> 2019;18(4):e12979. doi:10.1111\/acel.12979<\/p>\n

Predicting Age From the Transcriptome of Human Dermal Fibroblasts<\/a>
Fleischer JG, Schulte R, Tsai HH, et al. Genome Biol<\/em> 2018;19(1):221. Published 2018 Dec 20. doi:10.1186\/s13059-018-1599-6<\/p>\n

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies<\/a>
Horvath S, Oshima J, Martin GM, et al. Aging<\/em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632\/aging.101508<\/p>\n

Progerin sequestration of PCNA promotes replication fork collapse and mislocalization of XPA in laminopathy-related progeroid syndromes<\/a>
Hilton BA, Liu J, Cartwright BM<\/p>\n

Na\u00efve\u00a0adult stem cells\u00a0from\u00a0patients\u00a0with\u00a0Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo.
<\/a>Wenzel V, Roedl D, Gabriel D, Gordon LB, Herlyn M, Schneider R, Ring J, Djabali K.
Biol Open.<\/i>\u00a02012 Jun 15;1(6):516-26. Epub 2012 Apr 16.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN188″ module_id=”HGADFN188″ _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN188<\/strong><\/h4>\n

Transcriptional profiling of Hutchinson-Gilford Progeria patients identifies primary target pathways of progerin<\/a>
Vidak S, Kim S, Misteli T. Preprint.\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125. Published 2025 Sep 20. doi:10.1101\/2025.09.18.677125<\/p>\n

Impact of miR-181a on SIRT1 Expression and Senescence in Hutchinson-Gilford Progeria Syndrome<\/a>
Lederer EM, Fenzl FQ, Kr\u00fcger P, Schroll M, Hartinger R, Djabali K. Diseases<\/em>. 2025;13(8):245. Published 2025 Aug 4. doi:10.3390\/diseases13080245<\/p>\n

Aberrant migration features in primary skin fibroblasts of Huntington’s disease patients hold potential for unraveling disease progression using an image based machine learning tool<\/a>
Gharaba S, Shalem A, Paz O, Muchtar N, Wolf L, Weil M. Comput Biol Med<\/em>. Published online August 2, 2024. doi:10.1016\/j.compbiomed.2024.108970<\/p>\n

Perturbed actin cap as a new personalized biomarker in primary fibroblasts of Huntington’s disease patients<\/a>
Gharaba S, Paz O, Feld L, Abashidze A, Weinrab M, Muchtar N, Baransi A, Shalem A, Sprecher U, Wolf L, Wolfenson H, Weil M. Front Cell Dev Biol. 2023 Jan 18;11:1013721. doi: 10.3389\/fcell.2023.1013721. PMID: 36743412; PMCID: PMC9889876.<\/p>\n

Establishment and Characterization of hTERT Immortalized Hutchinson-Gilford Progeria Fibroblast Cell Lines<\/a>
Lin H, Mensch J, Haschke M, et al. Cells. 2022;11(18):2784. Published 2022 Sep 6. doi:10.3390\/cells11182784<\/p>\n

SerpinE1 drives a cell-autonomous pathogenic signaling in Hutchinson-Gilford progeria syndrome<\/a>
Catarinella G, Nicoletti C, Bracaglia A, et al. Cell Death Dis. 2022;13(8):737. Published 2022 Aug 26. doi:10.1038\/s41419-022-05168-y<\/p>\n

Nuclear Pore Complexes Cluster in Dysmorphic Nuclei of Normal and Progeria Cells during Replicative Senescence.
<\/a>R\u00f6hrl JM, Arnold R, Djabali K. Cells. 2021 Jan 14;10(1):153. doi: 10.3390\/cells10010153. PMID: 33466669; PMCID: PMC7828780.<\/p>\n

SAMMY-seq reveals early alteration of heterochromatin and deregulation of bivalent genes in Hutchinson-Gilford Progeria SyndromeNat <\/a>
Sebesty\u00e9n E, Marullo F, Lucini F, Petrini C, Bianchi A, Valsoni S, Olivieri I, Antonelli L, Gregoretti F, Oliva G, Ferrari F, Lanzuolo C. Commun. 2020 Dec 8;11(1):6274. doi: 10.1038\/s41467-020-20048-9. PMID: 33293552; PMCID: PMC7722762.<\/p>\n

Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome<\/a>
Bersini S, Schulte R, Huang L, Tsai H, Hetzer MW. Elife<\/em>. 2020 Sep 8;9:e54383. doi: 10.7554\/eLife.54383. PMID: 32896271; PMCID: PMC7478891.<\/p>\n

Epigenetic Deregulation of Lamina-Associated Domains in Hutchinson-Gilford Progeria Syndrome<\/a>
K\u00f6hler F, Bormann F, Raddatz G, et al. Genome Med<\/em> 2020;12(1):46. Published 2020 May 25. doi:10.1186\/s13073-020-00749-y<\/p>\n

Inhibition of JAK-STAT Signaling With Baricitinib Reduces Inflammation and Improves Cellular Homeostasis in Progeria Cells<\/a>
Liu C, Arnold R, Henriques G, Djabali K. Cells<\/em> 2019;8(10):1276. Published 2019 Oct 18. doi:10.3390\/cells8101276<\/p>\n

Analysis of Somatic Mutations Identifies Signs of Selection During in Vitro Aging of Primary Dermal Fibroblasts<\/a>
Narisu N, Rothwell R, Vrta\u010dnik P, et al. Aging Cell<\/em> 2019;18(6):e13010. doi:10.1111\/acel.13010<\/p>\n

Predicting Age From the Transcriptome of Human Dermal Fibroblasts<\/a>
Fleischer JG, Schulte R, Tsai HH, et al. Genome Biol<\/em> 2018;19(1):221. Published 2018 Dec 20. doi:10.1186\/s13059-018-1599-6<\/p>\n

p53\u00a0isoforms\u00a0regulate\u00a0premature aging\u00a0in\u00a0human\u00a0cells.
<\/a>von Muhlinen N, Horikawa I, Alam F, Isogaya K, Lissa D, Vojtesek B, Lane DP, Harris CC.
Oncogene<\/em>. 2018 Feb 12. doi: 10.1038\/s41388-017-0101-3. [Epub ahead of print]<\/p>\n

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies<\/a>
Horvath S, Oshima J, Martin GM, et al. Aging<\/em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632\/aging.101508<\/p>\n

Temsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular Phenotype.<\/a>
Gabriel D, Gordon LB, Djabali K. PLoS One<\/em> 2016;11(12):e0168988. Published 2016 Dec 29. doi:10.1371\/journal.pone.0168988<\/p>\n

Progerin Impairs Chromosome Maintenance by Depleting CENP-F From Metaphase Kinetochores in Hutchinson-Gilford Progeria Fibroblasts<\/a>
Eisch V, Lu X, Gabriel D, Djabali K. Oncotarget<\/em> 2016;7(17):24700-24718. doi:10.18632\/oncotarget.8267<\/p>\n

Sulforaphane\u00a0enhances\u00a0progerin clearance in Hutchinson-Gilford progeria fibroblasts.
<\/a>Gabriel D, Roedl D, Gordon LB, Djabali K.\u00a0Aging Cell<\/i>. 2014 Dec 16: 1-14.<\/p>\n

Depleting\u00a0the\u00a0methyltransferase\u00a0Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.
<\/a>Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z.\u00a0Nat Commun<\/i>. 2013;4:1868.<\/p>\n

Na\u00efve\u00a0adult stem cells\u00a0from\u00a0patients\u00a0with\u00a0Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo.
<\/a>Wenzel V, Roedl D, Gabriel D, Gordon LB, Herlyn M, Schneider R, Ring J, Djabali K.
Biol Open.<\/i>\u00a02012 Jun 15;1(6):516-26. Epub 2012 Apr 16.<\/p>\n

Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition.<\/a>
Marji J, O\u2019Donoghue SI, McClintock D, Satagopam VP, Schneider R, Ratner D, Worman HJ, Gordon LB, Djabali K.\u00a0PLoS One<\/em>. 2010 Jun 15;5(6):e11132.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN271″ module_id=”HGADFN271″ _builder_version=”4.27.5″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN271<\/strong><\/h4>\n

Senescence-inhibitory \u0394133p53\u03b1 counteracts accelerated ageing and mortality<\/a>
Yamada L, Liu H, von Muhlinen N, Harris CC, Horikawa I. Preprint.\u00a0bioRxiv<\/em>. 2026;2025.12.31.697195. Published 2026 Jan 20. doi:10.64898\/2025.12.31.697195<\/p>\n

Selection of specific and efficient siRNAs in new cellular model for Hutchinson-Gilford progeria syndrome therapy<\/a>
Dzianisava V, Piekarowicz K, Machowska M, Rzepecki R. Mol Ther Nucleic Acids<\/em>. 2025;36(4):102727. Published 2025 Oct 3. doi:10.1016\/j.omtn.2025.102727<\/p>\n

Transcriptional profiling of Hutchinson-Gilford Progeria patients identifies primary target pathways of progerin<\/a>
Vidak S, Kim S, Misteli T. Preprint.\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125. Published 2025 Sep 20. doi:10.1101\/2025.09.18.677125<\/p>\n

Impact of miR-181a on SIRT1 Expression and Senescence in Hutchinson-Gilford Progeria Syndrome<\/a>
Lederer EM, Fenzl FQ, Kr\u00fcger P, Schroll M, Hartinger R, Djabali K. Diseases<\/em>. 2025;13(8):245. Published 2025 Aug 4. doi:10.3390\/diseases13080245<\/p>\n

Pharmacologic activation of \u0394133p53\u03b1 reduces cellular senescence in progeria patients-derived cells<\/a>
Joruiz SM, Lissa D, Von Muhlinen N, et al. Preprint.\u00a0bioRxiv<\/em>. 2025;2025.07.28.667224. Published 2025 Aug 2. doi:10.1101\/2025.07.28.667224<\/p>\n

A Quantitative High-Throughput Screen Identifies Compounds that Upregulate the p53 Isoform \u0394133p53\u03b1 and Inhibit Cellular Senescence<\/a>
Lissa D, Joruiz SM, Dranchak PK, et al.\u00a0ACS Pharmacol Transl Sci<\/em>. 2025;8(7):2061-2074. Published 2025 Jun 20. doi:10.1021\/acsptsci.5c00186<\/p>\n

Enhancing Cellular Homeostasis: Targeted Botanical Compounds Boost Cellular Health Functions in Normal and Premature Aging Fibroblasts<\/a>
Hartinger R, Singh K, Leverett J, Djabali K. Biomolecules<\/em>. 2024;14(10):1310. Published 2024 Oct 16. doi:10.3390\/biom14101310<\/p>\n

Aberrant migration features in primary skin fibroblasts of Huntington’s disease patients hold potential for unraveling disease progression using an image based machine learning tool<\/a>
Gharaba S, Shalem A, Paz O, Muchtar N, Wolf L, Weil M. Comput Biol Med<\/em>. Published online August 2, 2024. doi:10.1016\/j.compbiomed.2024.108970<\/p>\n

Perturbed actin cap as a new personalized biomarker in primary fibroblasts of Huntington’s disease patients<\/a>
Gharaba S, Paz O, Feld L, Abashidze A, Weinrab M, Muchtar N, Baransi A, Shalem A, Sprecher U, Wolf L, Wolfenson H, Weil M. Front Cell Dev Biol. 2023 Jan 18;11:1013721. doi: 10.3389\/fcell.2023.1013721. PMID: 36743412; PMCID: PMC9889876.<\/p>\n

SAMMY-seq reveals early alteration of heterochromatin and deregulation of bivalent genes in Hutchinson-Gilford Progeria SyndromeNat <\/a>
Sebesty\u00e9n E, Marullo F, Lucini F, Petrini C, Bianchi A, Valsoni S, Olivieri I, Antonelli L, Gregoretti F, Oliva G, Ferrari F, Lanzuolo C. Commun. 2020 Dec 8;11(1):6274. doi: 10.1038\/s41467-020-20048-9. PMID: 33293552; PMCID: PMC7722762.<\/p>\n

Epigenetic Deregulation of Lamina-Associated Domains in Hutchinson-Gilford Progeria Syndrome<\/a>
K\u00f6hler F, Bormann F, Raddatz G, et al. Genome Med<\/em>. 2020;12(1):46. Published 2020 May 25. doi:10.1186\/s13073-020-00749-y<\/p>\n

Transient Introduction of Human Telomerase mRNA Improves Hallmarks of Progeria Cells<\/a>
Li Y, Zhou G, Bruno IG, et al. Aging Cell<\/em> 2019;18(4):e12979. doi:10.1111\/acel.12979<\/p>\n

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies<\/a>
Horvath S, Oshima J, Martin GM, et al. Aging<\/em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632\/aging.101508<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN367″ module_id=”HGADFN367″ _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN367<\/strong><\/h4>\n

Generation of Nonintegrative-Induced Pluripotent Stem Cells in Hutchinson-Gilford Progeria Syndrome: Enhancing Aging Research<\/a>
Kadiwala J, Shakur R.\u00a0Aging Med (Milton)<\/em>. 2025;8(5):493-498. Published 2025 Sep 22. doi:10.1002\/agm2.70041<\/p>\n

Selection of specific and efficient siRNAs in new cellular model for Hutchinson-Gilford progeria syndrome therapy<\/a>
Dzianisava V, Piekarowicz K, Machowska M, Rzepecki R. Mol Ther Nucleic Acids<\/em>. 2025;36(4):102727. Published 2025 Oct 3. doi:10.1016\/j.omtn.2025.102727<\/p>\n

A longevity-associated variant of the human BPIFB4 gene prevents diastolic dysfunction in progeria mice<\/a>
Qiu Y, Cattaneo M, Maciag A, Puca AA, Madeddu P.\u00a0Signal Transduct Target Ther<\/em>. 2025;10(1):314. Published 2025 Sep 29. doi:10.1038\/s41392-025-02416-3<\/p>\n

Transcriptional profiling of Hutchinson-Gilford Progeria patients identifies primary target pathways of progerin<\/a>
Vidak S, Kim S, Misteli T. Preprint.\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125. Published 2025 Sep 20. doi:10.1101\/2025.09.18.677125<\/p>\n

The NLRP3 inhibitor Dapansutrile improves the therapeutic action of lonafarnib on progeroid mice<\/a>
Muela-Zarzuela I, Suarez-Rivero JM, Boy-Ruiz D, et al. Aging Cell<\/em>. Published online August 27, 2024. doi:10.1111\/acel.14272<\/p>\n

Aberrant migration features in primary skin fibroblasts of Huntington’s disease patients hold potential for unraveling disease progression using an image based machine learning tool<\/a>
Gharaba S, Shalem A, Paz O, Muchtar N, Wolf L, Weil M. Comput Biol Med<\/em>. Published online August 2, 2024. doi:10.1016\/j.compbiomed.2024.108970<\/p>\n

Hutchinson-Gilford progeria patient-derived cardiomyocyte model of carrying LMNA gene variant c.1824 C > T<\/a>
Perales S, Sigamani V, Rajasingh S, Czirok A, Rajasingh J. [published online ahead of print, 2023 Aug 12].\u00a0Cell Tissue Res<\/em>. 2023;10.1007\/s00441-023-03813-2. doi:10.1007\/s00441-023-03813-2<\/p>\n

Perturbed actin cap as a new personalized biomarker in primary fibroblasts of Huntington’s disease patients<\/a>
Gharaba S, Paz O, Feld L, Abashidze A, Weinrab M, Muchtar N, Baransi A, Shalem A, Sprecher U, Wolf L, Wolfenson H, Weil M. Front Cell Dev Biol. 2023 Jan 18;11:1013721. doi: 10.3389\/fcell.2023.1013721. PMID: 36743412; PMCID: PMC9889876.<\/p>\n

SerpinE1 drives a cell-autonomous pathogenic signaling in Hutchinson-Gilford progeria syndrome<\/a>
Catarinella G, Nicoletti C, Bracaglia A, et al. Cell Death Dis. 2022;13(8):737. Published 2022 Aug 26. doi:10.1038\/s41419-022-05168-y<\/p>\n

Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson-Gilford Progeria<\/a>
Gonz\u00e1lez-Dominguez A, Monta\u00f1ez R, Castej\u00f3n-Vega B, et al. [published online ahead of print, 2021 Aug 27].\u00a0EMBO Mol Med<\/em>. 2021;e14012. doi:10.15252\/emmm.202114012<\/p>\n

A targeted antisense therapeutic approach for Hutchinson-Gilford progeria syndrome
<\/a>Erdos MR, Cabral WA, Tavarez UL, Cao K, Gvozdenovic-Jeremic J, Narisu N, Zerfas PM, Crumley S, Boku Y, Hanson G, Mourich DV, Kole R, Eckhaus MA, Gordon LB, Collins FS. Nat Med. 2021 Mar;27(3):536-545. doi: 10.1038\/s41591-021-01274-0. Epub 2021 Mar 11. PMID: 33707773.<\/p>\n

Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome<\/a>
Bersini S, Schulte R, Huang L, Tsai H, Hetzer MW. Elife<\/em>. 2020 Sep 8;9:e54383. doi: 10.7554\/eLife.54383. PMID: 32896271; PMCID: PMC7478891.<\/p>\n

Transient Introduction of Human Telomerase mRNA Improves Hallmarks of Progeria Cells<\/a>
Li Y, Zhou G, Bruno IG, et al. Aging Cell<\/em> 2019;18(4):e12979. doi:10.1111\/acel.12979<\/p>\n

Predicting Age From the Transcriptome of Human Dermal Fibroblasts<\/a>
Fleischer JG, Schulte R, Tsai HH, et al. Genome Biol<\/em> 2018;19(1):221. Published 2018 Dec 20. doi:10.1186\/s13059-018-1599-6<\/p>\n

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies<\/a>
Horvath S, Oshima J, Martin GM, et al. Aging<\/em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632\/aging.101508<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGMDFN368″ module_id=”HGMDFN368″ _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGMDFN368<\/strong><\/h4>\n

Selection of specific and efficient siRNAs in new cellular model for Hutchinson-Gilford progeria syndrome therapy<\/a>
Dzianisava V, Piekarowicz K, Machowska M, Rzepecki R. Mol Ther Nucleic Acids<\/em>. 2025;36(4):102727. Published 2025 Oct 3. doi:10.1016\/j.omtn.2025.102727<\/p>\n

A longevity-associated variant of the human BPIFB4 gene prevents diastolic dysfunction in progeria mice<\/a>
Qiu Y, Cattaneo M, Maciag A, Puca AA, Madeddu P.\u00a0Signal Transduct Target Ther<\/em>. 2025;10(1):314. Published 2025 Sep 29. doi:10.1038\/s41392-025-02416-3<\/p>\n

Transcriptional profiling of Hutchinson-Gilford Progeria patients identifies primary target pathways of progerin<\/a>
Vidak S, Kim S, Misteli T. Preprint.\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125. Published 2025 Sep 20. doi:10.1101\/2025.09.18.677125<\/p>\n

Impact of miR-181a on SIRT1 Expression and Senescence in Hutchinson-Gilford Progeria Syndrome<\/a>
Lederer EM, Fenzl FQ, Kr\u00fcger P, Schroll M, Hartinger R, Djabali K. Diseases<\/em>. 2025;13(8):245. Published 2025 Aug 4. doi:10.3390\/diseases13080245<\/p>\n

Enhancing Cellular Homeostasis: Targeted Botanical Compounds Boost Cellular Health Functions in Normal and Premature Aging Fibroblasts<\/a>
Hartinger R, Singh K, Leverett J, Djabali K. Biomolecules<\/em>. 2024;14(10):1310. Published 2024 Oct 16. doi:10.3390\/biom14101310<\/p>\n

The NLRP3 inhibitor Dapansutrile improves the therapeutic action of lonafarnib on progeroid mice<\/a>
Muela-Zarzuela I, Suarez-Rivero JM, Boy-Ruiz D, et al. Aging Cell<\/em>. Published online August 27, 2024. doi:10.1111\/acel.14272<\/p>\n

Hutchinson-Gilford progeria patient-derived cardiomyocyte model of carrying LMNA gene variant c.1824 C > T<\/a>
Perales S, Sigamani V, Rajasingh S, Czirok A, Rajasingh J. [published online ahead of print, 2023 Aug 12].\u00a0Cell Tissue Res<\/em>. 2023;10.1007\/s00441-023-03813-2. doi:10.1007\/s00441-023-03813-2<\/p>\n

Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson-Gilford Progeria<\/a>
Gonz\u00e1lez-Dominguez A, Monta\u00f1ez R, Castej\u00f3n-Vega B, et al. [published online ahead of print, 2021 Aug 27].\u00a0EMBO Mol Med<\/em>. 2021;e14012. doi:10.15252\/emmm.202114012<\/p>\n

A targeted antisense therapeutic approach for Hutchinson-Gilford progeria syndrome
<\/a>Erdos MR, Cabral WA, Tavarez UL, Cao K, Gvozdenovic-Jeremic J, Narisu N, Zerfas PM, Crumley S, Boku Y, Hanson G, Mourich DV, Kole R, Eckhaus MA, Gordon LB, Collins FS. Nat Med. 2021 Mar;27(3):536-545. doi: 10.1038\/s41591-021-01274-0. Epub 2021 Mar 11. PMID: 33707773.<\/p>\n

Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome<\/a>
Bersini S, Schulte R, Huang L, Tsai H, Hetzer MW. Elife<\/em>. 2020 Sep 8;9:e54383. doi: 10.7554\/eLife.54383. PMID: 32896271; PMCID: PMC7478891.<\/p>\n

Transient Introduction of Human Telomerase mRNA Improves Hallmarks of Progeria Cells<\/a>
Li Y, Zhou G, Bruno IG, et al. Aging Cell<\/em> 2019;18(4):e12979. doi:10.1111\/acel.12979<\/p>\n

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies<\/a>
Horvath S, Oshima J, Martin GM, et al. Aging<\/em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632\/aging.101508<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGFDFN369″ module_id=”HGFDFN369″ _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGFDFN369<\/strong><\/h4>\n

A longevity-associated variant of the human BPIFB4 gene prevents diastolic dysfunction in progeria mice<\/a>
Qiu Y, Cattaneo M, Maciag A, Puca AA, Madeddu P.\u00a0Signal Transduct Target Ther<\/em>. 2025;10(1):314. Published 2025 Sep 29. doi:10.1038\/s41392-025-02416-3<\/p>\n

Transcriptional profiling of Hutchinson-Gilford Progeria patients identifies primary target pathways of progerin<\/a>
Vidak S, Kim S, Misteli T. Preprint.\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125. Published 2025 Sep 20. doi:10.1101\/2025.09.18.677125<\/p>\n

Impact of miR-181a on SIRT1 Expression and Senescence in Hutchinson-Gilford Progeria Syndrome<\/a>
Lederer EM, Fenzl FQ, Kr\u00fcger P, Schroll M, Hartinger R, Djabali K. Diseases<\/em>. 2025;13(8):245. Published 2025 Aug 4. doi:10.3390\/diseases13080245<\/p>\n

Enhancing Cellular Homeostasis: Targeted Botanical Compounds Boost Cellular Health Functions in Normal and Premature Aging Fibroblasts<\/a>
Hartinger R, Singh K, Leverett J, Djabali K. Biomolecules<\/em>. 2024;14(10):1310. Published 2024 Oct 16. doi:10.3390\/biom14101310<\/p>\n

Hutchinson-Gilford progeria patient-derived cardiomyocyte model of carrying LMNA gene variant c.1824 C > T<\/a>Perales S, Sigamani V, Rajasingh S, Czirok A, Rajasingh J. [published online ahead of print, 2023 Aug 12].\u00a0Cell Tissue Res<\/em>. 2023;10.1007\/s00441-023-03813-2. doi:10.1007\/s00441-023-03813-2<\/p>\n

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies<\/a>
Horvath S, Oshima J, Martin GM, et al. Agi<\/em><\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN370″ module_id=”HGADFN370″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN370<\/strong><\/h4>\n

Imbalanced Nucleocytoskeletal Connections Create Common Polarity Defects in Progeria and Physiological Aging<\/a>
Chang W, Wang Y, Luxton GWG, \u00d6stlund C, Worman HJ, Gundersen GG.\u00a0 Proc Natl Acad Sci U S A<\/em>. 2019;116(9):3578\u20103583. doi:10.1073\/pnas.1809683116<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGMDFN371″ module_id=”HGMDFN371″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGMDFN371<\/strong><\/h4>\n

Imbalanced Nucleocytoskeletal Connections Create Common Polarity Defects in Progeria and Physiological Aging<\/a>
Chang W, Wang Y, Luxton GWG, \u00d6stlund C, Worman HJ, Gundersen GG.\u00a0 Proc Natl Acad Sci U S A<\/em>. 2019;116(9):3578\u20103583. doi:10.1073\/pnas.1809683116<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN496″ module_id=”HGADFN496″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN496<\/strong><\/h4>\n

A targeted antisense therapeutic approach for Hutchinson-Gilford progeria syndrome
<\/a>Erdos MR, Cabral WA, Tavarez UL, Cao K, Gvozdenovic-Jeremic J, Narisu N, Zerfas PM, Crumley S, Boku Y, Hanson G, Mourich DV, Kole R, Eckhaus MA, Gordon LB, Collins FS. Nat Med. 2021 Mar;27(3):536-545. doi: 10.1038\/s41591-021-01274-0. Epub 2021 Mar 11. PMID: 33707773.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGMDFN717″ module_id=”HGMDFN717″ _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGMDFN717<\/strong><\/h4>\n

A longevity-associated variant of the human BPIFB4 gene prevents diastolic dysfunction in progeria mice<\/a>
Qiu Y, Cattaneo M, Maciag A, Puca AA, Madeddu P.\u00a0Signal Transduct Target Ther<\/em>. 2025;10(1):314. Published 2025 Sep 29. doi:10.1038\/s41392-025-02416-3<\/p>\n

Transcriptional profiling of Hutchinson-Gilford Progeria patients identifies primary target pathways of progerin<\/a>
Vidak S, Kim S, Misteli T. Preprint.\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125. Published 2025 Sep 20. doi:10.1101\/2025.09.18.677125<\/p>\n

Hutchinson-Gilford progeria patient-derived cardiomyocyte model of carrying LMNA gene variant c.1824 C > T<\/a>
Perales S, Sigamani V, Rajasingh S, Czirok A, Rajasingh J. [published online ahead of print, 2023 Aug 12]. Cell Tissue Res<\/em>. 2023;10.1007\/s00441-023-03813-2. doi:10.1007\/s00441-023-03813-2<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGMDFN718″ module_id=”HGMDFN718″ _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGMDFN718<\/strong><\/h4>\n

A longevity-associated variant of the human BPIFB4 gene prevents diastolic dysfunction in progeria mice<\/a>
Qiu Y, Cattaneo M, Maciag A, Puca AA, Madeddu P.\u00a0Signal Transduct Target Ther<\/em>. 2025;10(1):314. Published 2025 Sep 29. doi:10.1038\/s41392-025-02416-3<\/p>\n

Transcriptional profiling of Hutchinson-Gilford Progeria patients identifies primary target pathways of progerin<\/a>
Vidak S, Kim S, Misteli T. Preprint.\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125. Published 2025 Sep 20. doi:10.1101\/2025.09.18.677125<\/p>\n

A targeted antisense therapeutic approach for Hutchinson-Gilford progeria syndrome
<\/a>Erdos MR, Cabral WA, Tavarez UL, Cao K, Gvozdenovic-Jeremic J, Narisu N, Zerfas PM, Crumley S, Boku Y, Hanson G, Mourich DV, Kole R, Eckhaus MA, Gordon LB, Collins FS. Nat Med. 2021 Mar;27(3):536-545. doi: 10.1038\/s41591-021-01274-0. Epub 2021 Mar 11. PMID: 33707773.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”PSADFN086″ module_id=”PSADFN086″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

PSADFN086
<\/strong>(formally HGADFN086)<\/u><\/h4>\n

\u00a0<\/strong>Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies<\/a>
Horvath S, Oshima J, Martin GM, et al. Aging<\/em> (Albany NY).<\/p>\n

Increased progerin expression associated with unusual LMNA mutations causes severe progeroid syndromes.<\/a>
Moulson CL, Fong LG, Gardner JM, Farber EA, Go G, Passariello A, Grange DK, Young SG, Miner JH.\u00a0Hum Mutat.<\/em>\u00a02007 Sep;28(9):882-9.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”PSADFN257″ module_id=”PSADFN257″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

PSADFN257<\/strong><\/h4>\n

A\u00a0Cell-Intrinsic\u00a0Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.
<\/a>Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S.\u00a0Cell Rep<\/em>. 2018 Feb 20;22(8):2006-2015.<\/p>\n

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies<\/a>
Horvath S, Oshima J, Martin GM, et al. Aging<\/em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632\/aging.101508<\/p>\n

Vitamin D Receptor Signaling Improves Hutchinson-Gilford Progeria Syndrome Cellular Phenotypes<\/a>
Kreienkamp R, Croke M, Neumann MA, et al. Oncotarget<\/em> 2016;7(21):30018-30031. doi:10.18632\/oncotarget.9065<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”PSADFN317″ module_id=”PSADFN317″ _builder_version=”4.21.0″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

PSADFN317<\/strong><\/h4>\n

Impact of Combined Baricitinib and FTI Treatment on Adipogenesis in Hutchinson-Gilford Progeria Syndrome and Other Lipodystrophic Laminopathies<\/a>
Hartinger R, Lederer EM, Schena E, Lattanzi G, Djabali K. Cells. 2023;12(10):1350. Published 2023 May 9. doi:10.3390\/cells12101350<\/p>\n

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies<\/a>
Horvath S, Oshima J, Martin GM, et al. Aging<\/em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632\/aging.101508<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”PSADFN318″ module_id=”PSADFN318″ _builder_version=”4.21.0″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

PSADFN318<\/strong><\/h4>\n

Impact of Combined Baricitinib and FTI Treatment on Adipogenesis in Hutchinson-Gilford Progeria Syndrome and Other Lipodystrophic Laminopathies<\/a>
Hartinger R, Lederer EM, Schena E, Lattanzi G, Djabali K. Cells. 2023;12(10):1350. Published 2023 May 9. doi:10.3390\/cells12101350<\/p>\n

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies<\/a>
Horvath S, Oshima J, Martin GM, et al. Aging<\/em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632\/aging.101508<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”PSFDFN319″ module_id=”PSFDFN319″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

PSFDFN319<\/strong><\/h4>\n

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies<\/a>
Horvath S, Oshima J, Martin GM, et al. Aging<\/em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632\/aging.101508<\/p>\n

Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells.<\/a>
Cao K, Graziotto JJ, Blair CD, Mazzulli JR, Erdos MR, Krainc D, Collins FS.\u00a0Sci Transl Med.<\/em>\u00a02011 Jun 29;3(89):89ra58.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”PSMDFN320″ module_id=”PSMDFN320″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

PSMDFN320<\/strong><\/h4>\n

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies<\/a>
Horvath S, Oshima J, Martin GM,<\/p>\n

Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells.<\/a>
Cao K, Graziotto JJ, Blair CD, Mazzulli JR, Erdos MR, Krainc D, Collins FS.\u00a0Sci Transl Med.<\/em>\u00a02011 Jun 29;3(89):89ra58.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”PSMDFN326″ module_id=”PSMDFN326″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

PSMDFN326<\/strong><\/h4>\n

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies<\/a>
Horvath S, Oshima J, Martin GM, et al. Aging<\/em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632\/aging.101508<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”PSFDFN327″ module_id=”PSFDFN327″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

PSFDFN327<\/strong><\/h4>\n

A\u00a0Cell-Intrinsic\u00a0Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.
<\/a>Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S.\u00a0Cell Rep<\/em>. 2018 Feb 20;22(8):2006-2015.<\/p>\n

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies<\/a>
Horvath S, Oshima J, Martin GM, et al. Aging<\/em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632\/aging.101508<\/p>\n

Vitamin D Receptor Signaling Improves Hutchinson-Gilford Progeria Syndrome Cellular Phenotypes<\/a>
Kreienkamp R, Croke M, Neumann MA, et al. Oncotarget<\/em> 2016;7(21):30018-30031. doi:10.18632\/oncotarget.9065<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”PSMDFN346″ module_id=”PSMDFN346″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

PSMDFN346<\/strong><\/h4>\n

A\u00a0Cell-Intrinsic\u00a0Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.
<\/a>Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S.\u00a0Cell Rep<\/em>. 2018 Feb 20;22(8):2006-2015.<\/p>\n

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies<\/a>
Horvath S, Oshima J, Martin GM, et al. Aging<\/em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632\/aging.101508<\/p>\n

Vitamin D Receptor Signaling Improves Hutchinson-Gilford Progeria Syndrome Cellular Phenotypes<\/a>
Kreienkamp R, Croke M, Neumann MA, et al. Oncotarget<\/em> 2016;7(21):30018-30031. doi:10.18632\/oncotarget.9065<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”PSADFN363″ module_id=”PSADFN363″ _builder_version=”4.24.3″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

PSADFN363<\/strong><\/h4>\n

The farnesyl transferase inhibitor (FTI) lonafarnib improves nuclear morphology in ZMPSTE24-deficient fibroblasts from patients with the progeroid disorder MAD-B<\/a>
Odinammadu KO, Shilagardi K, Tuminelli K, Judge DP, Gordon LB, Michaelis S. Nucleus<\/em>. 2023;14(1):2288476. doi:10.1080\/19491034.2023.2288476<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”PSADFN373″ module_id=”PSADFN373″ _builder_version=”4.27.5″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

PSADFN373<\/strong><\/h4>\n

Farnesylated prelamin A induces fibroblast polarity defects in premature aging disorders by inhibiting nesprin-2-SUN2 LINC complex function – PubMed<\/a>
Lio C, Wang Y, Wilson PC, et al. J Cell Sci<\/em>. 2026;139(12):jcs264488. doi:10.1242\/jcs.264488<\/p>\n

Targeting RAS-converting enzyme 1 overcomes senescence and improves progeria-like phenotypes of ZMPSTE24 deficiency<\/a>
Yao H, Chen X, Kashif M, Wang T, Ibrahim MX, T\u00fcksammel E, Rev\u00eachon G, Eriksson M, Wiel C, Bergo MO. Aging Cell. 2020 Aug;19(8):e13200. doi: 10.1111\/acel.13200. Epub 2020 Jul 24. PMID: 32910507; PMCID: PMC7431821.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”PSADFN392″ module_id=”PSADFN392″ _builder_version=”4.24.3″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

PSADFN392<\/strong><\/h4>\n

A novel somatic mutation achieves partial rescue in a child with Hutchinson-Gilford progeria syndrome<\/a>
Bar DZ, Arlt MF, Brazier JF, et al. J Med Genet<\/em>. 2017;54(3):212-216. doi:10.1136\/jmedgenet-2016-104295<\/p>\n

A\u00a0Cell-Intrinsic\u00a0Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.
<\/a>Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S.\u00a0Cell Rep<\/em>. 2018 Feb 20;22(8):2006-2015.<\/p>\n

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies<\/a>
Horvath S, Oshima J, Martin GM, et al. Aging<\/em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632\/aging.101508<\/p>\n

Vitamin D Receptor Signaling Improves Hutchinson-Gilford Progeria Syndrome Cellular Phenotypes<\/a>
Kreienkamp R, Croke M, Neumann MA, et al. Oncotarget<\/em> 2016;7(21):30018-30031. doi:10.18632\/oncotarget.9065<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”PSADFN423″ module_id=”PSADFN423″ _builder_version=”4.24.3″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

PSADFN423<\/strong><\/h4>\n

A novel somatic mutation achieves partial rescue in a child with Hutchinson-Gilford progeria syndrome<\/a>
Bar DZ, Arlt MF, Brazier JF, et al. J Med Genet<\/em>. 2017;54(3):212-216. doi:10.1136\/jmedgenet-2016-104295<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”PSADFN485″ module_id=”PSADFN485″ _builder_version=”4.24.3″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

PSADFN485<\/h4>\n

The farnesyl transferase inhibitor (FTI) lonafarnib improves nuclear morphology in ZMPSTE24-deficient fibroblasts from patients with the progeroid disorder MAD-B<\/a>
Odinammadu KO, Shilagardi K, Tuminelli K, Judge DP, Gordon LB, Michaelis S. Nucleus<\/em>. 2023;14(1):2288476. doi:10.1080\/19491034.2023.2288476<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”PSADFN542″ module_id=”PSADFN542″ _builder_version=”4.24.3″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

PSADFN542<\/h4>\n

The farnesyl transferase inhibitor (FTI) lonafarnib improves nuclear morphology in ZMPSTE24-deficient fibroblasts from patients with the progeroid disorder MAD-B<\/a>
Odinammadu KO, Shilagardi K, Tuminelli K, Judge DP, Gordon LB, Michaelis S. Nucleus<\/em>. 2023;14(1):2288476. doi:10.1080\/19491034.2023.2288476<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”PSADFN386″ module_id=”PSADFN386″ _builder_version=”4.24.3″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

PSADFN386<\/strong><\/h4>\n

A novel somatic mutation achieves partial rescue in a child with Hutchinson-Gilford progeria syndrome<\/a>
Bar DZ, Arlt MF, Brazier JF, et al. J Med Genet<\/em>. 2017;54(3):212-216. doi:10.1136\/jmedgenet-2016-104295<\/p>\n

MG132 Induces Progerin Clearance and Improves Disease Phenotypes in HGPS-like Patients’ Cells<\/a>
Harhouri K, Cau P, Casey F, et al. Cells<\/em>. 2022;11(4):610. Published 2022 Feb 10. doi:10.3390\/cells11040610<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”PSMDFN371″ module_id=”PSMDFN371″ _builder_version=”4.24.3″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

PSMDFN371<\/strong><\/h4>\n

A novel somatic mutation achieves partial rescue in a child with Hutchinson-Gilford progeria syndrome<\/a>Bar DZ, Arlt MF, Brazier JF, et al. J Med Genet<\/em>. 2017;54(3):212-216. doi:10.1136\/jmedgenet-2016-104295<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”PSMDFN387″ module_id=”PSMDFN387″ _builder_version=”4.24.3″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

PSMDFN387<\/strong><\/h4>\n

A novel somatic mutation achieves partial rescue in a child with Hutchinson-Gilford progeria syndrome<\/a>Bar DZ, Arlt MF, Brazier JF, et al. J Med Genet<\/em>. 2017;54(3):212-216. doi:10.1136\/jmedgenet-2016-104295<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”PSFDFN376″ module_id=”PSFDFN376″ _builder_version=”4.27.5″ custom_margin=”50px||50px||true” hover_enabled=”0″ z_index_tablet=”500″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

PSFDFN376<\/strong><\/h4>\n

Farnesylated prelamin A induces fibroblast polarity defects in premature aging disorders by inhibiting nesprin-2-SUN2 LINC complex function – PubMed<\/a>
Lio C, Wang Y, Wilson PC, et al. J Cell Sci<\/em>. 2026;139(12):jcs264488. doi:10.1242\/jcs.264488<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”PSFDFN388″ module_id=”PSFDFN388″ _builder_version=”4.27.5″ custom_margin=”50px||50px||true” hover_enabled=”0″ z_index_tablet=”500″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

PSFDFN388<\/strong><\/h4>\n

A novel somatic mutation achieves partial rescue in a child with Hutchinson-Gilford progeria syndrome<\/a>
Bar DZ, Arlt MF, Brazier JF, et al. J Med Genet<\/em>. 2017;54(3):212-216. doi:10.1136\/jmedgenet-2016-104295<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”PSMDFN393″ module_id=”PSMDFN393″ _builder_version=”4.24.3″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

PSMDFN393<\/strong><\/h4>\n

A novel somatic mutation achieves partial rescue in a child with Hutchinson-Gilford progeria syndrome<\/a>Bar DZ, Arlt MF, Brazier JF, et al. J Med Genet<\/em>. 2017;54(3):212-216. doi:10.1136\/jmedgenet-2016-104295<\/p>\n

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies<\/a>
Horvath S, Oshima J, Martin GM, et al. Aging<\/em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632\/aging.101508<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”PSFDFN394″ module_id=”PSFDFN394″ _builder_version=”4.24.3″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

PSFDFN394<\/strong><\/h4>\n

A novel somatic mutation achieves partial rescue in a child with Hutchinson-Gilford progeria syndrome<\/a>
Bar DZ, Arlt MF, Brazier JF, et al. J Med Genet<\/em>. 2017;54(3):212-216. doi:10.1136\/jmedgenet-2016-104295<\/p>\n

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies<\/a>
Horvath S, Oshima J, Martin GM, et al. Aging<\/em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632\/aging.101508<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”PSADFN414″ module_id=”PSADFN414″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

PSADFN414<\/strong><\/h4>\n

Everolimus Rescues Multiple Cellular Defects in Laminopathy-Patient Fibroblasts<\/a>
DuBose AJ, Lichtenstein ST, Petrash NM, Erdos MR, Gordon LB, Collins FS [published correction appears in Proc Natl Acad Sci U S A. 2018 Apr 16;:]. Proc Natl Acad Sci U S A<\/em>. 2018;115(16):4206\u20104211. doi:10.1073\/pnas.1802811115<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”PSADFN425″ module_id=”PSADFN425″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

PSADFN425<\/strong><\/h4>\n

Everolimus Rescues Multiple Cellular Defects in Laminopathy-Patient Fibroblasts<\/a>
DuBose AJ, Lichtenstein ST, Petrash NM, Erdos MR, Gordon LB, Collins FS [published correction appears in Proc Natl Acad Sci U S A. 2018 Apr 16;:].<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN003 iPS1B” module_id=”HGADFN003 iPS1B” _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN003 iPS1B<\/strong><\/h4>\n

iPSC-Derived Endothelial Cells Affect Vascular Function in a Tissue-Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome<\/a>
Atchison L, Abutaleb NO, Snyder-Mounts E, et al. Stem Cell Reports<\/em> 2020;14(2):325\u2010337. doi:10.1016\/j.stemcr.2020.01.005<\/p>\n

Progerin Phosphorylation in Interphase Is Lower and Less Mechanosensitive Than lamin-A,C in iPS-derived Mesenchymal Stem Cells<\/a>
Cho S, Abbas A, Irianto J, et al.. Nucleus<\/em> 2018;9(1):230-245. doi:10.1080\/19491034.2018.1460185<\/p>\n

Reprogramming Progeria Fibroblasts Re-Establishes a Normal Epigenetic Landscape<\/a>Chen Z, Chang WY, Etheridge A, et al. Aging Cell<\/em> 2017;16(4):870\u2010887. doi:10.1111\/acel.12621<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN003 iPS1C” module_id=”HGADFN003 iPS1C” _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN003 iPS1C<\/strong><\/h4>\n

Adenine base editing rescues pathogenic phenotypes in tissue engineered vascular model of Hutchinson-Gilford progeria syndrome<\/a>
Abutaleb NO, Gao XD, Bedapudi A, et al.\u00a0APL Bioeng<\/em>. 2025;9(1):016110. Published 2025 Feb 26. doi:10.1063\/5.0244026<\/p>\n

Progeria-based vascular model identifies networks associated with cardiovascular aging and disease<\/a>
Ngubo M, Chen Z, McDonald D, et al.\u00a0Aging Cell<\/em>. Published online April 4, 2024. doi:10.1111\/acel.14150<\/p>\n

iPSC-Derived Endothelial Cells Affect Vascular Function in a Tissue-Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome <\/a>
Atchison L, Abutaleb NO, Snyder-Mounts E, et al. Stem Cell Reports<\/em> 2020;14(2):325\u2010337. doi:10.1016\/j.stemcr.2020.01.005<\/p>\n

Reprogramming Progeria Fibroblasts Re-Establishes a Normal Epigenetic Landscape<\/a>
Chen Z, Chang WY, Etheridge A, et al. Aging Cell<\/em>. 2017;16(4):870\u2010887. doi:10.1111\/acel.12621<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN003 iPS1D” module_id=”HGADFN003 iPS1D” _builder_version=”4.27.5″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN003 iPS1D<\/strong><\/h4>\n

Hutchinson-Gilford progeria syndrome alters the endothelial genetic response to laminar shear stress<\/a>
Kennedy CC, Carter JL, Truskey GA.\u00a0Front Physiol<\/em>. 2026;16:1599339. Published 2026 Feb 24. doi:10.3389\/fphys.2025.1599339<\/p>\n

Adenine base editing rescues pathogenic phenotypes in tissue engineered vascular model of Hutchinson-Gilford progeria syndrome<\/a>
Abutaleb NO, Gao XD, Bedapudi A, et al.\u00a0APL Bioeng<\/em>. 2025;9(1):016110. Published 2025 Feb 26. doi:10.1063\/5.0244026<\/p>\n

Lonafarnib and everolimus reduce pathology in iPSC-derived tissue engineered blood vessel model of Hutchinson-Gilford Progeria Syndrome.<\/a>
Abutaleb NO, Atchison L, Choi L, Bedapudi A, Shores K, Gete Y, Cao K, Truskey GA. Sci Rep. 2023 Mar 28;13(1):5032. doi: 10.1038\/s41598-023-32035-3. PMID: 36977745; PMCID: PMC10050176.<\/p>\n

iPSC-Derived Endothelial Cells Affect Vascular Function in a Tissue-Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome<\/a>
Atchison L, Abutaleb NO, Snyder-Mounts E, et al. Stem Cell Reports<\/em> 2020;14(2):325\u2010337. doi:10.1016\/j.stemcr.2020.01.005<\/p>\n

Dysfunction of iPSC-derived Endothelial Cells in Human Hutchinson-Gilford Progeria Syndrome<\/a>
Matrone G, Thandavarayan RA, Walther BK, Meng S, Mojiri A, Cooke JP. Cell Cycle <\/em>2019;18(19):2495\u20102508. doi:10.1080\/15384101.2019.1651587<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGMDFN090 iPS1B” module_id=”HGMDFN090 iPS1B” _builder_version=”4.27.5″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGMDFN090 iPS1B<\/strong><\/h4>\n

Hutchinson-Gilford progeria syndrome alters the endothelial genetic response to laminar shear stress<\/a>
Kennedy CC, Carter JL, Truskey GA.\u00a0Front Physiol<\/em>. 2026;16:1599339. Published 2026 Feb 24. doi:10.3389\/fphys.2025.1599339<\/p>\n

Dysfunction of iPSC-derived Endothelial Cells in Human Hutchinson-Gilford Progeria Syndrome<\/a>
Matrone G, Thandavarayan RA, Walther BK, Meng S, Mojiri A, Cooke JP. Cell Cycle<\/em> 2019;18(19):2495\u20102508. doi:10.1080\/15384101.2019.1651587<\/p>\n

\u00a0<\/strong>Reprogramming Progeria Fibroblasts Re-Establishes a Normal Epigenetic Landscape<\/a>
Chen Z, Chang WY, Etheridge A, et al. Aging Cell<\/em>. 2017;16(4):870\u2010887. doi:10.1111\/acel.12621<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGMDFN090 iPS1C” module_id=”HGMDFN090 iPS1C” _builder_version=”4.24.0″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGMDFN090 iPS1C<\/strong><\/h4>\n

Progeria-based vascular model identifies networks associated with cardiovascular aging and disease<\/a>
Ngubo M, Chen Z, McDonald D, et al.\u00a0Aging Cell<\/em>. Published online April 4, 2024. doi:10.1111\/acel.14150<\/p>\n

Aging Model for Analyzing Drug-Induced Proarrhythmia Risks Using Cardiomyocytes Differentiated from Progeria-Patient-Derived Induced Pluripotent Stem Cells<\/a>
Daily N, Elson J, Wakatsuki T.\u00a0Int J Mol Sci<\/em>. 2023;24(15):11959. Published 2023 Jul 26. doi:10.3390\/ijms241511959<\/p>\n

Reprogramming Progeria Fibroblasts Re-Establishes a Normal Epigenetic Landscape<\/a>
Chen Z, Chang WY, Etheridge A, et al. Aging Cell<\/em>. 2017;16(4):870\u2010887. doi:10.1111\/acel.12621<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN167 iPS1J” module_id=”HGADFN167 iPS1J” _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN167 iPS1J<\/strong><\/h4>\n

Patient-Derived Cortical Organoids Reveal Senescence of Neural Progenitor Cells in Hutchinson-Gilford Progeria Syndrome<\/a>
Jeon S, Park CS, Hong J, et al.\u00a0Aging Cell<\/em>. Published online June 30, 2025. doi:10.1111\/acel.70143<\/p>\n

Aging Model for Analyzing Drug-Induced Proarrhythmia Risks Using Cardiomyocytes Differentiated from Progeria-Patient-Derived Induced Pluripotent Stem Cells<\/a>
Daily N, Elson J, Wakatsuki T.\u00a0Int J Mol Sci<\/em>. 2023;24(15):11959. Published 2023 Jul 26. doi:10.3390\/ijms241511959<\/p>\n

Modelling premature cardiac aging with induced pluripotent stem cells from a Hutchinson-Gilford Progeria Syndrome patient<\/a>
Monnerat G, Kasai-Brunswick TH, Asensi KD, et al. Modelling premature cardiac aging with induced pluripotent stem cells from a hutchinson-gilford Progeria Syndrome patient.\u00a0Front Physiol<\/em>. 2022;13:1007418. Published 2022 Nov 23. doi:10.3389\/fphys.2022.1007418<\/p>\n

Reprogramming Progeria Fibroblasts Re-Establishes a Normal Epigenetic Landscape<\/a>
Chen Z, Chang WY, Etheridge A, et al. Aging Cell<\/em>. 2017;16(4):870\u2010887. doi:10.1111\/acel.12621<\/p>\n

Mechanisms Controlling the Smooth Muscle Cell Death in Progeria via Down-Regulation of poly(ADP-ribose) Polymerase 1<\/a>
Zhang H, Xiong ZM, Cao K. Proc Natl Acad Sci U S A.<\/em> 2014;111(22):E2261\u2010E2270. doi:10.1073\/pnas.1320843111<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN167 iPS1Q” module_id=”HGADFN167 iPS1Q” _builder_version=”4.27.5″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN167 iPS1Q<\/strong><\/h4>\n

A Long-lived Avatar for Modeling Age-Related Vascular Disease<\/a>
Qin W, Tran TN, Xiao Y, et al. Preprint.\u00a0bioRxiv<\/em>. 2026;2026.04.29.721776. Published 2026 May 4. doi:10.64898\/2026.04.29.721776<\/p>\n

Circular RNA Telomerase Reverses Endothelial Senescence in Progeria<\/a>
Qin W, Castillo KD, Li H, et al.\u00a0Aging Cell<\/em>. Published online February 23, 2025. doi:10.1111\/acel.70021<\/p>\n

Vascular senescence in progeria: role of endothelial dysfunction<\/a>
Xu Q, Mojiri A, Boulahouache L, Morales E, Walther BK, Cooke JP. Eur Heart J Open. 2022;2(4):oeac047. Published 2022 Jul 28. doi:10.1093\/ehjopen\/oeac047<\/p>\n

Dysfunction of iPSC-derived Endothelial Cells in Human Hutchinson-Gilford Progeria Syndrome<\/a>
Matrone G, Thandavarayan RA, Walther BK, Meng S, Mojiri A, Cooke JP. Cell Cycle<\/em> 2019;18(19):2495\u20102508. doi:10.1080\/15384101.2019.1651587<\/p>\n

Reprogramming Progeria Fibroblasts Re-Establishes a Normal Epigenetic Landscape<\/a>
Chen Z, Chang WY, Etheridge A, et al. Aging Cell<\/em> 2017;16(4):870\u2010887. doi:10.1111\/acel.12621<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGFDFN168 iPS1D2″ module_id=”HGFDFN168 iPS1D2″ _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGFDFN168 iPS1D2<\/strong><\/h4>\n

Patient-Derived Cortical Organoids Reveal Senescence of Neural Progenitor Cells in Hutchinson-Gilford Progeria Syndrome<\/a>
Jeon S, Park CS, Hong J, et al.\u00a0Aging Cell<\/em>. Published online June 30, 2025. doi:10.1111\/acel.70143<\/p>\n

Adenine base editing rescues pathogenic phenotypes in tissue engineered vascular model of Hutchinson-Gilford progeria syndrome<\/a>
Abutaleb NO, Gao XD, Bedapudi A, et al.\u00a0APL Bioeng<\/em>. 2025;9(1):016110. Published 2025 Feb 26. doi:10.1063\/5.0244026<\/p>\n

Reprogramming Progeria Fibroblasts Re-Establishes a Normal Epigenetic Landscape<\/a>
Chen Z, Chang WY, Etheridge A, et al. Aging Cell<\/em>. 2017;16(4):870\u2010887. doi:10.1111\/acel.12621<\/p>\n

\u00a0<\/strong>Mechanisms Controlling the Smooth Muscle Cell Death in Progeria via Down-Regulation of poly(ADP-ribose) Polymerase 1<\/a>
Zhang H, Xiong ZM, Cao K. Proc Natl Acad Sci U S A<\/em> 2014;111(22):E2261\u2010E2270. doi:10.1073\/pnas.1320843111<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGFDFN168 iPS1P” module_id=”HGFDFN168 iPS1P” _builder_version=”4.27.5″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGFDFN168 iPS1P<\/strong><\/h4>\n

A Long-lived Avatar for Modeling Age-Related Vascular Disease<\/a>
Qin W, Tran TN, Xiao Y, et al. Preprint.\u00a0bioRxiv<\/em>. 2026;2026.04.29.721776. Published 2026 May 4. doi:10.64898\/2026.04.29.721776<\/p>\n

Circular RNA Telomerase Reverses Endothelial Senescence in Progeria<\/a>
Qin W, Castillo KD, Li H, et al.\u00a0Aging Cell<\/em>. Published online February 23, 2025. doi:10.1111\/acel.70021<\/p>\n

Vascular senescence in progeria: role of endothelial dysfunction<\/a>
Xu Q, Mojiri A, Boulahouache L, Morales E, Walther BK, Cooke JP. Eur Heart J Open. 2022;2(4):oeac047. Published 2022 Jul 28. doi:10.1093\/ehjopen\/oeac047<\/p>\n

Dysfunction of iPSC-derived Endothelial Cells in Human Hutchinson-Gilford Progeria Syndrome<\/a>
Matrone G, Thandavarayan RA, Walther BK, Meng S, Mojiri A, Cooke JP. Cell Cycle<\/em> 2019;18(19):2495\u20102508. doi:10.1080\/15384101.2019.1651587<\/p>\n

Reprogramming Progeria Fibroblasts Re-Establishes a Normal Epigenetic Landscape<\/a>
Chen Z, Chang WY, Etheridge A, et al. Aging Cell<\/em> 2017;16(4):870\u2010887. doi:10.1111\/acel.12621<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGALBV009″ module_id=”HGALBV009″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGALBV009<\/strong><\/h4>\n

Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson-Gilford Progeria<\/a>
Gonz\u00e1lez-Dominguez A, Monta\u00f1ez R, Castej\u00f3n-Vega B, et al. [published online ahead of print, 2021 Aug 27].\u00a0EMBO Mol Med<\/em>. 2021;e14012. doi:10.15252\/emmm.202114012<\/p>\n

Stem cell depletion in Hutchinson-Gilford progeria syndrome.<\/a>
Rosengardten Y, McKenna T, Grochov\u00e1 D, Eriksson M.\u00a0Aging Cell.<\/em>\u00a02011 Dec;10(6):1011-20. Epub 2011 Oct 11.<\/p>\n

Low and high expressing alleles of the LMNA gene: implications for laminopathy disease development.<\/a>
Rodr\u00edguez S, Eriksson M.\u00a0PLoS One.<\/em>\u00a02011;6(9):e25472. Epub 2011 Sep 29.<\/p>\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>
Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS.\u00a0Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGMLBV010″ module_id=”HGMLBV010″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGMLBV010<\/strong><\/h4>\n

Stem cell depletion in Hutchinson-Gilford progeria syndrome.<\/a>
Rosengardten Y, McKenna T, Grochov\u00e1 D, Eriksson M.\u00a0Aging Cell.<\/em>\u00a02011 Dec;10(6):1011-20. Epub 2011 Oct 11.<\/p>\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>
Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS.\u00a0Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGALBV011″ module_id=”HGALBV011″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGALBV011<\/strong><\/h4>\n

Low and high expressing alleles of the LMNA gene: implications for laminopathy disease development.<\/a>
Rodr\u00edguez S, Eriksson M.\u00a0PL<\/em>oS One.<\/em>\u00a02011;6(9):e25472. Epub 2011 Sep 29.<\/p>\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>
Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS.\u00a0Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGMLBV013″ module_id=”HGMLBV013″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGMLBV013<\/strong><\/h4>\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>
Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS.\u00a0Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGFLBV021″ module_id=”HGFLBV021″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGFLBV021<\/strong><\/h4>\n

Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson-Gilford Progeria<\/a>
Gonz\u00e1lez-Dominguez A, Monta\u00f1ez R, Castej\u00f3n-Vega B, et al. [published online ahead of print, 2021 Aug 27].\u00a0EMBO Mol Med<\/em>. 2021;e14012. doi:10.15252\/emmm.202114012<\/p>\n

Stem cell depletion in Hutchinson-Gilford progeria syndrome.<\/a>
Rosengardten Y, McKenna T, Grochov\u00e1 D, Eriksson M.\u00a0Aging Cell.<\/em>\u00a02011 Dec;10(6):1011-20. Epub 2011 Oct 11.<\/p>\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>
Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS.\u00a0Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGMLBV023″ module_id=”HGMLBV023″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGMLBV023<\/strong><\/h4>\n

Stem cell depletion in Hutchinson-Gilford progeria syndrome.<\/a>
Rosengardten Y, McKenna T, Grochov\u00e1 D, Eriksson M.\u00a0Aging Cell.<\/em>\u00a02011 Dec;10(6):1011-20. Epub 2011 Oct 11.<\/p>\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>
Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS.\u00a0Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGFLBV031″ module_id=”HGFLBV031″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGFLBV031<\/strong><\/h4>\n

Stem cell depletion in Hutchinson-Gilford progeria syndrome.<\/a>
Rosengardten Y, McKenna T, Grochov\u00e1 D, Eriksson M.\u00a0Aging Cell.<\/em>\u00a02011 Dec;10(6):1011-20. Epub 2011 Oct 11.<\/p>\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>
Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS.\u00a0Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGFLBV050″ module_id=”HGFLBV050″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGFLBV050<\/strong><\/h4>\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>
Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS.\u00a0Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGALBV057″ module_id=”HGALBV057″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGALBV057<\/strong><\/h4>\n

Stem cell depletion in Hutchinson-Gilford progeria syndrome.<\/a>
Rosengardten Y, McKenna T, Grochov\u00e1 D, Eriksson M.\u00a0Aging Cell.<\/em>\u00a02011 Dec;10(6):1011-20. Epub 2011 Oct 11.<\/p>\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>
Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS.\u00a0Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGMLBV058″ module_id=”HGMLBV058″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGMLBV058<\/strong><\/h4>\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>
Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS.\u00a0Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGSLBV059″ module_id=”HGMLBV058″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGSLBV059<\/strong><\/h4>\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>
Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS.\u00a0Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.\u00a0<\/strong><\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGMLBV066″ module_id=”HGMLBV066″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGMLBV066<\/strong><\/h4>\n

Stem cell depletion in Hutchinson-Gilford progeria syndrome.<\/a>
Rosengardten Y, McKenna T, Grochov\u00e1 D, Eriksson M.\u00a0Aging Cell.<\/em>\u00a02011 Dec;10(6):1011-20. Epub 2011 Oct 11.<\/p>\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>
Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS.\u00a0Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGFLBV067″ module_id=”HGFLBV067″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGFLBV067<\/strong><\/h4>\n

Stem cell depletion in Hutchinson-Gilford progeria syndrome.<\/a>
Rosengardten Y, McKenna T, Grochov\u00e1 D, Eriksson M.\u00a0Aging Cell.<\/em>\u00a02011 Dec;10(6):1011-20. doi: 10.1111\/j.1474-9726.2011.00743.x. Epub 2011 Oct 11.<\/p>\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>
Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS.\u00a0Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGALBV071″ module_id=”HGALBV071″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGALBV071<\/strong><\/h4>\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>
Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS.\u00a0Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGMLBV081″ module_id=”HGMLBV081″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGMLBV081<\/strong><\/h4>\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>
Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS.\u00a0Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGFLBV082″ module_id=”HGFLBV082″ _builder_version=”4.16″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGFLBV082<\/strong><\/h4>\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>
Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS.\u00a0Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”DNA” module_id=”DNA” _builder_version=”4.17.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

DNA<\/strong><\/h4>\n

Clonal hematopoiesis is not prevalent in Hutchinson-Gilford progeria syndrome<\/a>
D\u00edez-D\u00edez M, Amor\u00f3s-P\u00e9rez M, de la Barrera J, et al. [published online ahead of print, 2022 Jun 25]. Geroscience. 2022;10.1007\/s11357-022-00607-2. doi:10.1007\/s11357-022-00607-2<\/p>\n

A Novel Somatic Mutation Achieves Partial Rescue in a Child With Hutchinson-Gilford Progeria Syndrome<\/a>
Bar DZ, Arlt MF, Brazier JF, et al. J Med Genet<\/em> 2017;54(3):212-216. doi:10.1136\/jmedgenet-2016-104295<\/p>\n

Transient introduction of human telomerase mRNA improves hallmarks of progeria cells<\/a>
Li Y, Zhou G, Bruno IG, et al. Aging Cell<\/em> 2019;18(4):e12979. doi:10.1111\/acel.12979<\/p>\n

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies<\/a>
Horvath S, Oshima J, Martin GM, et al. Aging<\/em> (Albany NY). 2018;10(7):1758-1775. doi:10.18632\/aging.101508<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”Autopsy tissue” module_id=”Autopsy tissue” _builder_version=”4.24.0″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

Autopsy tissue<\/strong><\/h4>\n

Remodeling of the Cardiac Extracellular Matrix Proteome During Chronological and Pathological Aging<\/a>
Santinha D, Vila\u00e7a A, Estronca L, et al.\u00a0Mol Cell Proteomics<\/em>. 2024;23(1):100706. doi:10.1016\/j.mcpro.2023.100706<\/p>\n

Atherosclerosis in ancient humans, accelerated aging syndromes and normal aging: is lamin a protein a common link?<\/a>
Miyamoto MI, Djabali K, Gordon LB. Glob Heart<\/em>. 2014;9(2):211-218. doi:10.1016\/j.gheart.2014.04.001<\/p>\n

Cardiovascular Pathology in Hutchinson-Gilford Progeria: Correlation With the Vascular Pathology of Aging<\/a>
Olive M, Harten I, Mitchell R, et al. Arterioscler Thromb Vasc Biol<\/em> 2010;30(11):2301-2309. doi:10.1161\/ATVBAHA.110.209460<\/p>\n

Hutchinson-Gilford Progeria Mutant Lamin A Primarily Targets Human Vascular Cells as Detected by an anti-Lamin A G608G Antibody<\/a>
McClintock D, Gordon LB, Djabali K. Proc Natl Acad Sci U S A.<\/em> 2006;103(7):2154-2159. doi:10.1073\/pnas.0511133103<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”Plasma” module_id=”Plasma” _builder_version=”4.24.0″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

Plasma<\/strong><\/h4>\n

Aged-vascular niche hinders osteogenesis of mesenchymal stem cells through paracrine repression of Wnt-axis<\/a>
Fleischhacker V, Milosic F, Bricelj M, et al.\u00a0Aging Cell<\/em>. Published online April 5, 2024. doi:10.1111\/acel.14139<\/p>\n

Metabolomic Profiling Suggests Systemic Signatures of Premature Aging Induced by Hutchinson-Gilford Progeria Syndrome<\/a>
Monnerat G, Evaristo GPC, Evaristo JAM, et al. Metabolomics<\/em> 2019;15(7):100. Published 2019 Jun 28. doi:10.1007\/s11306-019-1558-6<\/p>\n

Plasma Progerin in Patients With Hutchinson-Gilford Progeria Syndrome: Immunoassay Development and Clinical Evaluation<\/a>
Gordon LB, Norris W, Hamren S, et al.\u00a0Circulation<\/em>. 2023;147(23):1734-1744. doi:10.1161\/CIRCULATIONAHA.122.060002<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”Serum” module_id=”Serum” _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

Serum<\/strong><\/h4>\n

Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome<\/a>
Bersini S, Schulte R, Huang L, Tsai H, Hetzer MW. Elife<\/em>. 2020 Sep 8;9:e54383. doi: 10.7554\/eLife.54383. PMID: 32896271; PMCID: PMC7478891.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”Buffy Coats” module_id=”buffycoats” _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

Buffy Coats<\/strong><\/h4>\n

Quantification of Farnesylated Progerin in Hutchinson-Gilford Progeria Patient Cells by Mass Spectrometry<\/a>
Camafeita E, Jorge I, Rivera-Torres J, Andr\u00e9s V, V\u00e1zquez J. Int J Mol Sci<\/em>. 2022;23(19):11733. Published 2022 Oct 3. doi:10.3390\/ijms231911733<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”Zokinvy (lonafarnib)” module_id=”zokinvy” _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

Zokinvy (lonafarnib) <\/strong><\/h4>\n

Baricitinib and Lonafarnib Synergistically Target Progerin and Inflammation, Improving Lifespan and Health in Progeria Mice<\/a>
Kr\u00fcger P, Schroll M, Fenzl FQ, et al.\u00a0Int J Mol Sci<\/em>. 2025;26(10):4849. Published 2025 May 19. doi:10.3390\/ijms26104849<\/p>\n

The farnesyl transferase inhibitor (FTI) lonafarnib improves nuclear morphology in ZMPSTE24-deficient fibroblasts from patients with the progeroid disorder MAD-B<\/a>
Odinammadu KO, Shilagardi K, Tuminelli K, Judge DP, Gordon LB, Michaelis S. Nucleus<\/em>. 2023;14(1):2288476. doi:10.1080\/19491034.2023.2288476<\/p>\n

Lonafarnib and everolimus reduce pathology in iPSC-derived tissue engineered blood vessel model of Hutchinson-Gilford Progeria Syndrome.<\/a>
Abutaleb NO, Atchison L, Choi L, Bedapudi A, Shores K, Gete Y, Cao K, Truskey GA. Sci Rep. 2023 Mar 28;13(1):5032. doi: 10.1038\/s41598-023-32035-3. PMID: 36977745; PMCID: PMC10050176.<\/p>\n

Lonafarnib improves cardiovascular function and survival in a mouse model of Hutchinson-Gilford progeria syndrome.<\/a>
Murtada SI, Mikush N, Wang M, Ren P, Kawamura Y, Ramachandra AB, Li DS, Braddock DT, Tellides G, Gordon LB, Humphrey JD. Elife. 2023 Mar 17;12:e82728. doi: 10.7554\/eLife.82728. PMID: 36930696; PMCID: PMC10023154.<\/p>\n

Systematic screening identifies therapeutic antisense oligonucleotides for Hutchinson-Gilford progeria syndrome. <\/a>
Puttaraju M, Jackson M, Klein S, Shilo A, Bennett CF, Gordon L, Rigo F, Misteli T. Nat Med. 2021 Mar;27(3):526-535. doi: 10.1038\/s41591-021-01262-4. Epub 2021 Mar 11. PMID: 33707772.<\/p>\n

Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome.<\/a>
Kang SM, Yoon MH, Ahn J, Kim JE, Kim SY, Kang SY, Joo J, Park S, Cho JH, Woo TG, Oh AY, Chung KJ, An SY, Hwang TS, Lee SY, Kim JS, Ha NC, Song GY, Park BJ. Commun Biol. 2021 Jan 4;4(1):5. doi: 10.1038\/s42003-020-01540-w. Erratum in: Commun Biol. 2021 Mar 2;4(1):297. PMID: 33398110; PMCID: PMC7782499.<\/p>\n

 <\/p>\n

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Together, we<\/h2>\n

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find the cure!<\/h2>\n

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[et_pb_section fb_built=”1″ fullwidth=”on” disabled_on=”off|off|off” _builder_version=”4.16″ border_width_bottom=”55px” border_color_bottom=”#29327a” locked=”off” global_colors_info=”{}”][et_pb_fullwidth_header _builder_version=”4.16″ title_font=”||||||||” title_font_size=”55″ background_color=”#29327a” background_image=”https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2020\/12\/Alexandra_1920x687.jpg” background_position=”center_left” custom_padding=”9vw||9vw||true” custom_padding_tablet=”” custom_padding_phone=”|56px||” custom_padding_last_edited=”on|desktop” title_font_size_tablet=”45px” title_font_size_phone=”40px” title_font_size_last_edited=”on|phone” z_index_tablet=”500″ custom_css_main_element=”background-position: center 18% !important;” global_colors_info=”{}”] PRF Cell and Tissue Bank Publications   [\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ use_custom_gutter=”on” gutter_width=”1″ specialty=”on” padding_left_1=”35px” padding_left_2=”35px” padding_2_tablet=”|||0px” padding_2_phone=”|||0px” padding_2_last_edited=”on|desktop” module_class_1=”sidebar-secondary-nav” module_class=”handprint-bg” _builder_version=”4.16″ background_image=”https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/blue-handprint-only.png” parallax=”on” parallax_method=”off” inner_width=”100%” inner_max_width=”100%” custom_padding=”0|0px|54px|0px|false|false” z_index_tablet=”500″ […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"\t\t\t\t[vc_row][vc_column][vc_custom_heading text=\"PRF Cell and Tissue Bank Publications\" font_container=\"tag:h1|text_align:center\" use_theme_fonts=\"yes\"][vc_column_text]Publications Stemming From\r\n<\/strong>The Progeria Research Foundation Cell and Tissue Bank\r\n\r\n<\/a>The Progeria Research Foundation Cell and Tissue Bank has contributed to the following medical publications, categorized by cell line for researcher convenience:\r\n\r\n\r\n\r\n
HGADFN001<\/strong><\/a>\r\n\r\nHGADFN003<\/strong><\/a>\r\n\r\nHGADFN004<\/strong><\/a>\r\n\r\nHGADFN005<\/strong><\/a>\r\n\r\nHGADFN008<\/strong><\/a>\r\n\r\nHGADFN014<\/strong><\/a>\r\n\r\nHGADFN086<\/strong><\/a>\r\n\r\nHGMDFN090<\/strong><\/a>\r\n\r\nHGADFN122<\/b><\/strong><\/a>\r\n\r\nHGADFN127<\/strong><\/a>\r\n\r\nHGADFN136<\/strong><\/a>\r\n\r\nHGADFN143<\/strong><\/a>\r\n\r\nHGADFN155<\/strong><\/a><\/td>\r\nHGADFN164<\/strong><\/a>\r\n\r\nHGADFN167<\/strong><\/a>\r\n\r\nHGFDFN168<\/strong><\/a>\r\n\r\nHGADFN169<\/strong><\/a>\r\n\r\nHGADFN178<\/strong><\/a>\r\n\r\nHGADFN188<\/strong><\/a>\r\n\r\nPSADFN257<\/strong><\/a>\r\n\r\nPSFDFN319<\/strong><\/a>\r\n\r\nPSMDFN320<\/strong><\/a>\r\n\r\nPSMDFN327<\/strong><\/a>\r\n\r\nPSMDFN346<\/strong><\/a>\r\n\r\nPSMDFN392<\/strong><\/a>\r\n\r\nHGALBV009<\/strong><\/a>\r\n\r\nHGMLBV010<\/strong><\/a><\/td>\r\nHGALBV011<\/strong><\/a>\r\n\r\nHGMLBV013<\/strong><\/a>\r\n\r\nHGFLBV021<\/strong><\/a>\r\n\r\nHGMLBV023<\/strong><\/a>\r\n\r\nHGFLBV031<\/strong><\/a>\r\n\r\nHGFLBV050<\/strong><\/a>\r\n\r\nHGALBV057<\/strong><\/a>\r\n\r\nHGMLBV058<\/strong><\/a>\r\n\r\nHGSLBV059<\/strong><\/a>\r\n\r\nHGMLBV066<\/a><\/strong>\r\n\r\nHGFLBV067<\/strong><\/a>\r\n\r\nHGALBV071<\/strong><\/a>\r\n\r\nHGMLBV081<\/strong><\/a>\r\n\r\nHGFLBV082<\/strong><\/a><\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n\u00a0\r\n\r\n\"\"For publications listed by cell line inclusion, Click here.<\/a><\/strong>\r\n<\/strong>\r\n

<\/a>HGADFN001<\/strong><\/p>\r\n

Age-dependent loss of MMP-3 in Hutchinson-Gilford progeria syndrome.<\/a>\r\nHarten IA, Zahr RS, Lemire JM, Machan JT, Moses MA, Doiron RJ, Curatolo AS, Rothman FG, Wight TN, Toole BP, Gordon LB. J Gerontol A Biol Sci Med Sci<\/em>. 2011 Nov;66(11):1201-7.<\/p>\r\n

The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin.<\/a>\r\nMcClintock D, Ratner D, Lokuge M, Owens DM, Gordon LB, Collins FS, Djabali K. PLoS One<\/em>. 2007 Dec 5;2(12):e1269.<\/p>\r\n

Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody.<\/a>\r\nMcClintock D, Gordon LB, Djabali K. Proc Natl Acad Sci U S A.<\/em> 2006 Feb 14;103(7):2154-9.<\/p>\r\n

Aggrecan expression is substantially and abnormally upregulated in Hutchinson-Gilford Progeria Syndrome dermal fibroblasts.<\/a>\r\nLemire JM, Patis C, Gordon LB, Sandy JD, Toole BP, Weiss AS. Mech Ageing Dev.<\/em> 2006 Aug;127(8):660-9.<\/p>\r\n

Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment.<\/a>\r\nColumbaro M, Capanni C, Mattioli E, Novelli G, Parnaik VK, Squarzoni S, Maraldi NM, Lattanzi G. Cell Mol Life Sci.<\/em> 2005 Nov;62(22):2669-78.<\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature.<\/em> 2003 May 15;423(6937):293-8.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGADFN003<\/strong><\/p>\r\nA\u00a0Cell-Intrinsic\u00a0Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.\r\n<\/a>Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S.\u00a0Cell Rep<\/em>. 2018 Feb 20;22(8):2006-2015.\r\n

Nucleoplasmic\u00a0lamins\u00a0define\u00a0growth-regulating functions of lamina-associated polypeptide 2\u03b1 in progeria cells.<\/a>\u00a0Vidak S, Georgiou K, Fichtinger P, Naetar N, Dechat T, Foisner R. J Cell Sci. 2017 Dec 28. pii: jcs.208462. doi: 10.1242\/jcs.208462. [Epub ahead of print]<\/p>\r\n

Intermittent\u00a0treatment\u00a0with\u00a0farnesyltransferase\u00a0inhibitor\u00a0and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts.\u00a0<\/a>Gabriel D, Shafry DD, Gordon LB, Djabali K.\u00a0Oncotarget<\/em>. 2017 Jul 18;8(39):64809-64826. doi: 10.18632\/oncotarget.19363. eCollection 2017 Sep 12.<\/p>\r\nReprogramming\u00a0progeria\u00a0fibroblasts\u00a0re-establishes a normal epigenetic landscape.<\/span><\/a>\u00a0Chen Z, Chang WY, Etheridge A, Strickfaden H, Jin Z, Palidwor G, Cho JH, Wang K, Kwon SY, Dor\u00e9 C, Raymond A, Hotta A, Ellis J, Kandel RA, Dilworth FJ, Perkins TJ, Hendzel MJ, Galas DJ, Stanford WL. .<\/span>Aging Cell<\/span><\/i>. 2017 Jun 8. [Epub ahead of print]<\/span>\r\n\r\nPermanent\u00a0farnesylation\u00a0of\u00a0lamin A\u00a0mutants linked to progeria impairs its phosphorylation at serine 22 during interphase.<\/span><\/a> Moiseeva O, Lopes-Paciencia S, Huot G, Lessard F, Ferbeyre G. <\/span>Aging<\/span><\/i> . 2016 Feb;8(2):366-81.<\/span>\r\n\r\nLamin A\u00a0Is an\u00a0Endogenous\u00a0SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair.<\/span><\/a>\u00a0Ghosh S, Liu B, Wang Y, Hao Q, Zhou Z. <\/span>Cell Rep<\/span><\/i>. 2015 Nov 17;13(7):1396-1406. doi: 10.1016\/j.celrep.2015.10.006. Epub 2015 Nov 5. PMID:26549451<\/span>\r\n

Proliferation\u00a0of\u00a0progeria\u00a0cells\u00a0is\u00a0enhanced\u00a0by\u00a0lamina-associated polypeptide 2\u03b1 (LAP2\u03b1) through expression of extracellular matrix proteins.\r\n<\/a>Vidak S, Kubben N, Dechat T, Foisner R. Genes & Development.<\/i> 2015 Oct 1;29(19):2022-36.<\/p>\r\n

Sulforaphane\u00a0enhances\u00a0progerin clearance in Hutchinson-Gilford progeria fibroblasts.\r\n<\/a>Gabriel D, Roedl D, Gordon LB, Djabali K. Aging Cell<\/i>. 2014 Dec 16: 1-14.<\/p>\r\n

Depleting\u00a0the\u00a0methyltransferase\u00a0Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.\r\n<\/a>Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z.Nat Commun<\/i>. 2013;4:1868.<\/p>\r\n

Na\u00efve\u00a0adult stem cells\u00a0from\u00a0patients\u00a0with\u00a0Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo.\r\n<\/a>Wenzel V, Roedl D, Gabriel D, Gordon LB, Herlyn M, Schneider R, Ring J, Djabali K.\r\nBiol Open<\/em>. 2012 Jun 15;1(6):516-26. Epub 2012 Apr 16<\/p>\r\n

Age-dependent loss of MMP-3 in Hutchinson-Gilford progeria syndrome.\r\n<\/a>Harten IA, Zahr RS, Lemire JM, Machan JT, Moses MA, Doiron RJ, Curatolo AS, Rothman FG, Wight TN, Toole BP, Gordon LB. J Gerontol A Biol Sci Med Sci<\/em>. 2011 Nov;66(11):1201-7.<\/p>\r\n

Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts.<\/a>\r\nCao K, Blair CD, Faddah DA, Kieckhaefer JE, Olive M, Erdos MR, Nabel EG, Collins FS. J Clin Invest.<\/em> 2011 Jul 1;121(7):2833-44<\/p>\r\n

Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition.<\/a>\r\nMarji J, O'Donoghue SI, McClintock D, Satagopam VP, Schneider R, Ratner D, Worman HJ, Gordon LB, Djabali K. PLoS One<\/em>. 2010 Jun 15;5(6):e11132.<\/p>\r\n

Effect of progerin on the accumulation of oxidized proteins in fibroblasts from Hutchinson Gilford progeria patients.<\/a>\r\nViteri G, Chung YW, Stadtman ER. Mech Ageing Dev<\/em>. 2010 Jan;131(1):2-8.<\/p>\r\n

Ageing-related chromatin defects through loss of the NURD complex.<\/a>\r\nPegoraro G, Kubben N, Wickert U, G\u00f6hler H, Hoffmann K, Misteli T. Nat Cell Biol.<\/em> 2009 Oct;11(10):1261-7.<\/p>\r\n

Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing.<\/a>\r\nScaffidi P, Misteli T. Nat Cell Biol. <\/em>2008 Apr;10(4):452-9.<\/p>\r\n

Perturbation of wild-type lamin A metabolism results in a progeroid phenotype.<\/a>\r\nCandelario J, Sudhakar S, Navarro S, Reddy S, Comai L. Aging Cell<\/em>. 2008 Jun;7(3):355-67<\/p>\r\n

Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging.<\/a>\r\nDechat T, Shimi T, Adam SA, Rusinol AE, Andres DA, Spielmann HP, Sinensky MS, Goldman RD. Proc Natl Acad Sci USA<\/em>. 2007 Mar 20;104(12):4955-60.<\/p>\r\n

The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin.<\/a>\r\nMcClintock D, Ratner D, Lokuge M, Owens DM, Gordon LB, Collins FS, Djabali K. PLoS One<\/em>. 2007 Dec 5;2(12):e1269.<\/p>\r\n

A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells.<\/a>\r\nCao K, Capell BC, Erdos MR, Djabali K, Collins FS. Proc Natl Acad Sci USA<\/em>. 2007 Mar 20;104(12):4949-54.<\/p>\r\n

Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody.<\/a>\r\nMcClintock D, Gordon LB, Djabali K. Proc Natl Acad Sci U S A.<\/em> 2006 Feb 14;103(7):2154-9.<\/p>\r\n

Aggrecan expression is substantially and abnormally upregulated in Hutchinson-Gilford Progeria Syndrome dermal fibroblasts.<\/a>\r\nLemire JM, Patis C, Gordon LB, Sandy JD, Toole BP, Weiss AS. Mech Ageing Dev.<\/em> 2006 Aug;127(8):660-9.<\/p>\r\n

Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment.<\/a>\r\nColumbaro M, Capanni C, Mattioli E, Novelli G, Parnaik VK, Squarzoni S, Maraldi NM, Lattanzi G. Cell Mol Life Sci.<\/em> 2005 Nov;62(22):2669-78.<\/p>\r\n

Genomic instability in laminopathy-based premature aging.<\/a>\r\nLiu B, Wang J, Chan KM, Tjia WM, Deng W, Guan X, Huang JD, Li KM, Chau PY, Chen DJ, Pei D, Pendas AM, Cadi\u00f1anos J, L\u00f3pez-Ot\u00edn C, Tse HF, Hutchison C, Chen J, Cao Y, Cheah KS, Tryggvason K, Zhou Z. Nat Med.<\/em> 2005 Jul;11(7):780-5.<\/p>\r\n

Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition.<\/a>\r\nGlynn MW, Glover TW. Hum Mol Genet. <\/em>2005 Oct 15;14(20):2959-69.<\/p>\r\n

Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome.<\/a>\r\nGoldman RD, Shumaker DK, Erdos MR, Eriksson M, Goldman AE, Gordon LB, Gruenbaum Y, Khuon S, Mendez M, Varga R, Collins FS. Proc Natl Acad Sci U S A<\/em>.<\/em><\/a> 2004 Jun 15;101(24):8963-8.<\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature.<\/em> 2003 May 15;423(6937):293-8.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGADFN004<\/strong>\u00a0<\/strong><\/p>\r\n

Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition.<\/a>\r\nGlynn MW, Glover TW. Hum Mol Genet. <\/em>2005 Oct 15;14(20):2959-69.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGADFN005<\/strong>\u00a0<\/strong><\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature.<\/em> 2003 May 15;423(6937):293-8.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGADFN008<\/strong>\u00a0<\/strong><\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature.<\/em> 2003 May 15;423(6937):293-8.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGADFN014<\/strong>\u00a0<\/strong><\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature.<\/em> 2003 May 15;423(6937):293-8.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGADFN086<\/strong><\/p>\r\n

Increased progerin expression associated with unusual LMNA mutations causes severe progeroid syndromes.<\/a>\r\nMoulson CL, Fong LG, Gardner JM, Farber EA, Go G, Passariello A, Grange DK, Young SG, Miner JH. Hum Mutat.<\/em> 2007 Sep;28(9):882-9.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGMDFN090<\/strong><\/p>\r\n

A\u00a0Cell-Intrinsic\u00a0Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.\r\n<\/a>Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S.\u00a0Cell Rep<\/em>. 2018 Feb 20;22(8):2006-2015.<\/p>\r\n

Nucleoplasmic\u00a0lamins\u00a0define\u00a0growth-regulating functions of lamina-associated polypeptide 2\u03b1 in progeria cells.<\/a>\u00a0Vidak S, Georgiou K, Fichtinger P, Naetar N, Dechat T, Foisner R. J Cell Sci. 2017 Dec 28. pii: jcs.208462. doi: 10.1242\/jcs.208462. [Epub ahead of print]<\/p>\r\n

Reprogramming\u00a0progeria\u00a0fibroblasts\u00a0re-establishes a normal epigenetic landscape.\u00a0<\/a>Chen Z, Chang WY, Etheridge A, Strickfaden H, Jin Z, Palidwor G, Cho JH, Wang K, Kwon SY, Dor\u00e9 C, Raymond A, Hotta A, Ellis J, Kandel RA, Dilworth FJ, Perkins TJ, Hendzel MJ, Galas DJ, Stanford WL. .Aging Cell<\/em>. 2017 Jun 8. [Epub ahead of print]<\/p>\r\n

Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria.\r\n<\/a>Xiong ZM, Choi JY, Wang K, Zhang H, Tariq Z, Wu D, Ko E, LaDana C, Sesaki H, Cao K. Aging Cell.<\/i><\/a>\u00a0 2015 Dec 14. [Epub ahead of print]<\/p>\r\n

Proliferation\u00a0of\u00a0progeria\u00a0cells\u00a0is\u00a0enhanced\u00a0by\u00a0lamina-associated polypeptide 2\u03b1 (LAP2\u03b1) through expression of extracellular matrix proteins.\r\n<\/a>Vidak S, Kubben N, Dechat T, Foisner R. Genes & Development.<\/i> 2015 Oct 1;29(19):2022-36.<\/p>\r\n

Higher-order\u00a0unfolding\u00a0of satellite heterochromatin is a consistent and early event in cell senescence.\r\n<\/a>Swanson EC, Manning B, Zhang H, Lawrence JB. J Cell Biol<\/i>. 2013 Dec 23;203(6):929-42<\/p>\r\n

Correlated\u00a0alterations\u00a0in\u00a0genome\u00a0organization,\u00a0histone\u00a0methylation, and DNA-lamin A\/C interactions in Hutchinson-Gilford progeria syndrome.\r\n<\/a>McCord RP, Nazario-Toole A, Zhang H, Chines PS, Zhan Y, Erdos MR, Collins FS, Dekker J, Cao K. Genome<\/i>\u00a0Res<\/i>. 2013 Feb;23(2):260-9. Epub 2012 Nov 14.<\/p>\r\n

Comparison of constitutional and replication stress-induced genome structural variation by SNP array and mate-pair sequencing.<\/a>\r\nArlt MF, Ozdemir AC, Birkeland SR, Lyons RH Jr, Glover TW, Wilson TE. Genetics<\/em>. 2011 Mar;187(3):675-83.<\/p>\r\n

Hydroxyurea induces de novo copy number variants in human cells.<\/a>\r\nArlt MF, Ozdemir AC, Birkeland SR, Wilson TE, Glover TW. Proc Natl Acad Sci USA.<\/em> 2011 Oct 18;108(42):17360-5<\/p>\r\n

Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts.<\/a>\r\nCao K, Blair CD, Faddah DA, Kieckhaefer JE, Olive M, Erdos MR, Nabel EG, Collins FS. J Clin Invest.<\/em> 2011 Jul 1;121(7):2833-44<\/p>\r\n

CTP:phosphocholine cytidylyltransferase \u03b1 (CCT\u03b1) and lamins alter nuclear membrane structure without affecting phosphatidylcholine synthesis.<\/a>\r\nGehrig K, Ridgway ND. Biochim Biophys Acta<\/em>. 2011 Jun;1811(6):377-85.<\/p>\r\n

Effect of progerin on the accumulation of oxidized proteins in fibroblasts from Hutchinson Gilford progeria patients.<\/a>\r\nViteri G, Chung YW, Stadtman ER. Mech Ageing Dev<\/em>. 2010 Jan;131(1):2-8.<\/p>\r\n

Replication stress induces genome-wide copy number changes in human cells that resemble polymorphic and pathogenic variants.<\/a>\r\nArlt MF, Mulle JG, Schaibley VM, Ragland RL, Durkin SG, Warren ST, Glover TW. Am J Hum Genet<\/em>. 2009 Mar;84(3):339-50.<\/p>\r\n

A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells.<\/a>\r\nCao K, Capell BC, Erdos MR, Djabali K, Collins FS. Proc Natl Acad Sci USA<\/em>. 2007 Mar 20;104(12):4949-54.<\/p>\r\n

Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition.<\/a>\r\nGlynn MW, Glover TW. Hum Mol Genet. <\/em>2005 Oct 15;14(20):2959-69.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGADFN122<\/b><\/p>\r\nMetformin\u00a0Alleviates\u00a0Aging\u00a0Cellular\u00a0Phenotypes in Hutchinson-Gilford Progeria Syndrome Dermal Fibroblasts<\/span>.<\/span><\/a>\u00a0Park SK, Shin OS.\u00a0<\/span>Exp Dermatol<\/span><\/i>. 2017 Feb 13. [Epub ahead of print]<\/span>\r\n\r\nLamin A\u00a0Is an\u00a0Endogenous\u00a0SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair.<\/span><\/a>\u00a0Ghosh S, Liu B, Wang Y, Hao Q, Zhou Z. <\/span>Cell Rep<\/span><\/i>. 2015 Nov 17;13(7):1396-1406. doi: 10.1016\/j.celrep.2015.10.006. Epub 2015 Nov 5. PMID:26549451<\/span>\r\n

Insights\u00a0into the\u00a0role\u00a0of\u00a0immunosenescence\u00a0during varicella zoster virus infection (shingles) in the aging cell model.\r\n<\/a>Kim JA, Park SK, Kumar M, Lee CH, Shin OS. Oncotarget<\/i>. 2015 Oct 14. [Epub ahead of print]<\/p>\r\n

Depleting\u00a0the\u00a0methyltransferase\u00a0Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.\r\n<\/a>Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z. Nat Commun<\/i>. 2013;4:1868.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGADFN127<\/strong><\/p>\r\n

Intermittent\u00a0treatment\u00a0with\u00a0farnesyltransferase\u00a0inhibitor\u00a0and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts.\u00a0<\/a>Gabriel D, Shafry DD, Gordon LB, Djabali K.\u00a0Oncotarget<\/em>. 2017 Jul 18;8(39):64809-64826. doi: 10.18632\/oncotarget.19363. eCollection 2017 Sep 12.<\/p>\r\nMetformin\u00a0Alleviates\u00a0Aging\u00a0Cellular\u00a0Phenotypes in Hutchinson-Gilford Progeria Syndrome Dermal Fibroblasts<\/span>.<\/span><\/a>\u00a0Park SK, Shin OS.\u00a0<\/span>Exp Dermatol<\/span><\/i>. 2017 Feb 13. [Epub ahead of print]<\/span>\r\n

Insights\u00a0into the\u00a0role\u00a0of\u00a0immunosenescence\u00a0during varicella zoster virus infection (shingles) in the aging cell model.\r\n<\/a>Kim JA, Park SK, Kumar M, Lee CH, Shin OS. Oncotarget<\/i>. 2015 Oct 14. [Epub ahead of print]<\/p>\r\n

Sulforaphane\u00a0enhances\u00a0progerin clearance in Hutchinson-Gilford progeria fibroblasts.\r\n<\/a>Gabriel D, Roedl D, Gordon LB, Djabali K. Aging Cell<\/i>. 2014 Dec 16: 1-14.<\/p>\r\n

A\u00a0proteomic\u00a0study\u00a0of\u00a0Hutchinson-Gilford progeria syndrome: Application of 2D-chromotography in a premature aging disease.\r\n<\/a>Wang L, Yang W, Ju W, Wang P, Zhao X, Jenkins EC, Brown WT, Zhong N. Biochem Biophys Res Commun.<\/i> 2012 Jan 27;417(4):1119-26. Epub 2011 Dec 24.<\/p>\r\n

Age-dependent loss of MMP-3 in Hutchinson-Gilford progeria syndrome.<\/a>\r\nHarten IA, Zahr RS, Lemire JM, Machan JT, Moses MA, Doiron RJ, Curatolo AS, Rothman FG, Wight TN, Toole BP, Gordon LB. J Gerontol A Biol Sci Med Sci<\/em>. 2011 Nov;66(11):1201-7.\r\n<\/strong><\/p>\r\n

CTP:phosphocholine cytidylyltransferase \u03b1 (CCT\u03b1) and lamins alter nuclear membrane structure without affecting phosphatidylcholine synthesis.<\/a>\r\nGehrig K, Ridgway ND. Biochim Biophys Acta<\/em>. 2011 Jun;1811(6):377-85.<\/p>\r\n

Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition.<\/a>\r\nMarji J, O'Donoghue SI, McClintock D, Satagopam VP, Schneider R, Ratner D, Worman HJ, Gordon LB, Djabali K. PLoS One<\/em>. 2010 Jun 15;5(6):e11132.<\/p>\r\n

Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: effects of farnesyltransferase inhibitors.<\/a>\r\nVerstraeten VL, Ji JY, Cummings KS, Lee RT, Lammerding J. Aging Cell.<\/em> 2008 Jun;7(3):383-93.<\/p>\r\n

Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging.<\/a>\r\nDechat T, Shimi T, Adam SA, Rusinol AE, Andres DA, Spielmann HP, Sinensky MS, Goldman RD. Proc Natl Acad Sci USA<\/em>. 2007 Mar 20;104(12):4955-60.<\/p>\r\n

The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin.<\/a>\r\nMcClintock D, Ratner D, Lokuge M, Owens DM, Gordon LB, Collins FS, Djabali K. PLoS One<\/em>. 2007 Dec 5;2(12):e1269.<\/p>\r\n

Aggrecan expression is substantially and abnormally upregulated in Hutchinson-Gilford Progeria Syndrome dermal fibroblasts.<\/a>\r\nLemire JM, Patis C, Gordon LB, Sandy JD, Toole BP, Weiss AS. Mech Ageing Dev<\/em>.<\/em><\/a> 2006 Aug;127(8):660-9<\/p>\r\n

Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody.<\/a>\r\nMcClintock D, Gordon LB, Djabali K. Proc Natl Acad Sci U S A.<\/em> 2006 Feb 14;103(7):2154-9.<\/p>\r\n

Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment.<\/a>\r\nColumbaro M, Capanni C, Mattioli E, Novelli G, Parnaik VK, Squarzoni S, Maraldi NM, Lattanzi G. Cell Mol Life Sci.<\/em> 2005 Nov;62(22):2669-78.<\/p>\r\n

Genomic instability in laminopathy-based premature aging.<\/a>\r\nLiu B, Wang J, Chan KM, Tjia WM, Deng W, Guan X, Huang JD, Li KM, Chau PY, Chen DJ, Pei D, Pendas AM, Cadi\u00f1anos J, L\u00f3pez-Ot\u00edn C, Tse HF, Hutchison C, Chen J, Cao Y, Cheah KS, Tryggvason K, Zhou Z. Nat Med.<\/em> 2005 Jul;11(7):780-5.<\/p>\r\n

Novel progerin-interactive partner proteins hnRNP E1, EGF, Mel 18, and UBC9 interact with lamin A\/C.<\/a>\r\nZhong N, Radu G, Ju W, Brown WT. Biochem Biophys Res Commun. <\/em>2005 Dec 16;338(2):855-61.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGADFN136<\/strong><\/p>\r\n

Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition.<\/a>\r\nGlynn MW, Glover TW. Hum Mol Genet. <\/em>2005 Oct 15;14(20):2959-69.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGADFN143<\/strong><\/p>\r\n

Depleting\u00a0the\u00a0methyltransferase\u00a0Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.\r\n<\/a>Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z. Nat Commun<\/i>. 2013;4:1868.<\/p>\r\n

CTP:phosphocholine cytidylyltransferase \u03b1 (CCT\u03b1) and lamins alter nuclear membrane structure without affecting phosphatidylcholine synthesis.<\/a>\r\nGehrig K, Ridgway ND. Biochim Biophys Acta.<\/em> 2011 Jun;1811(6):377-85.<\/p>\r\n

Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: effects of farnesyltransferase inhibitors.<\/a>\r\nVerstraeten VL, Ji JY, Cummings KS, Lee RT, Lammerding J. Aging Cell.<\/em> 2008 Jun;7(3):383-93.<\/p>\r\n

The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin.<\/a>\r\nMcClintock D, Ratner D, Lokuge M, Owens DM, Gordon LB, Collins FS, Djabali K. PLoS One<\/em>. 2007 Dec 5;2(12):e1269.<\/p>\r\n

Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody.<\/a>\r\nMcClintock D, Gordon LB, Djabali K. Proc Natl Acad Sci U S A.<\/em> 2006 Feb 14;103(7):2154-9.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGADFN155<\/strong><\/p>\r\n

Nucleoplasmic\u00a0lamins\u00a0define\u00a0growth-regulating functions of lamina-associated polypeptide 2\u03b1 in progeria cells.<\/a>\u00a0Vidak S, Georgiou K, Fichtinger P, Naetar N, Dechat T, Foisner R. J Cell Sci. 2017 Dec 28. pii: jcs.208462. doi: 10.1242\/jcs.208462. [Epub ahead of print]<\/p>\r\n

Intermittent\u00a0treatment\u00a0with\u00a0farnesyltransferase\u00a0inhibitor\u00a0and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts.\u00a0<\/a>Gabriel D, Shafry DD, Gordon LB, Djabali K.\u00a0Oncotarget<\/em>. 2017 Jul 18;8(39):64809-64826. doi: 10.18632\/oncotarget.19363. eCollection 2017 Sep 12.<\/p>\r\nLamin A\u00a0Is an\u00a0Endogenous\u00a0SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair.<\/span><\/a>\u00a0Ghosh S, Liu B, Wang Y, Hao Q, Zhou Z. <\/span>Cell Rep<\/span><\/i>. 2015 Nov 17;13(7):1396-1406. doi: 10.1016\/j.celrep.2015.10.006. Epub 2015 Nov 5. PMID:26549451<\/span>\r\n

Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair.\r\n<\/a>Ghosh S, Liu B, Wang Y, Hao Q, Zhou Z. Cell Rep<\/i>. 2015 Nov 4. [Epub ahead of print]<\/p>\r\n

Proliferation\u00a0of\u00a0progeria\u00a0cells\u00a0is\u00a0enhanced\u00a0by\u00a0lamina-associated polypeptide 2\u03b1 (LAP2\u03b1) through expression of extracellular matrix proteins.\r\n<\/a>Vidak S, Kubben N, Dechat T, Foisner R. Genes & Development.<\/i> 2015 Oct 1;29(19):2022-36.<\/p>\r\n

Sulforaphane\u00a0enhances\u00a0progerin clearance in Hutchinson-Gilford progeria fibroblasts.\r\n<\/a>Gabriel D, Roedl D, Gordon LB, Djabali K. Aging Cell<\/i>. 2014 Dec 16: 1-14.<\/p>\r\n

Higher-order\u00a0unfolding\u00a0of satellite heterochromatin is a consistent and early event in cell senescence.\r\n<\/a>Swanson EC, Manning B, Zhang H, Lawrence JB. J Cell Biol<\/i>. 2013 Dec 23;203(6):929-42.<\/p>\r\n

Correlated\u00a0alterations\u00a0in\u00a0genome\u00a0organization,\u00a0histone\u00a0methylation, and DNA-lamin A\/C interactions in Hutchinson-Gilford progeria syndrome.\r\n<\/a>McCord RP, Nazario-Toole A, Zhang H, Chines PS, Zhan Y, Erdos MR, Collins FS, Dekker J, Cao K. Genome<\/i>\u00a0Res<\/i>. 2013 Feb;23(2):260-9. Epub 2012 Nov 14.<\/p>\r\n

An\u00a0inhibitory\u00a0role\u00a0of\u00a0progerin\u00a0in the gene induction network of adipocyte differentiation from iPS cells.\r\n<\/a>Xiong ZM, LaDana C, Wu D, Cao K. Aging<\/i> (Albany NY). 2013 Apr;5(4):288-303.<\/p>\r\n

Depleting\u00a0the\u00a0methyltransferase\u00a0Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.\r\n<\/a>Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z. Nat Commun<\/i>. 2013;4:1868.<\/p>\r\n

Automated\u00a0image\u00a0analysis\u00a0of\u00a0nuclear\u00a0shape: what can we\u00a0learn\u00a0from a prematurely aged cell?\r\n<\/a>Driscoll MK, Albanese JL, Xiong ZM, Mailman M, Losert W, Cao K. Aging<\/i> (Albany NY). 2012 Feb;4(2):119-32.<\/p>\r\n

Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells.<\/a>\r\nCao K, Graziotto JJ, Blair CD, Mazzulli JR, Erdos MR, Krainc D, Collins FS. Sci Transl Med.<\/em> 2011 Jun 29;3(89):89ra58.<\/p>\r\n

Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition.<\/a>\r\nMarji J, O'Donoghue SI, McClintock D, Satagopam VP, Schneider R, Ratner D, Worman HJ, Gordon LB, Djabali K. PLoS One<\/em>. 2010 Jun 15;5(6):e11132.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGADFN164<\/strong><\/p>\r\n

Intermittent\u00a0treatment\u00a0with\u00a0farnesyltransferase\u00a0inhibitor\u00a0and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts.<\/a>Gabriel D, Shafry DD, Gordon LB, Djabali K.\u00a0Oncotarget<\/em>. 2017 Jul 18;8(39):64809-64826. doi: 10.18632\/oncotarget.19363. eCollection 2017 Sep 12.<\/p>\r\nLamin A\u00a0Is an\u00a0Endogenous\u00a0SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair.<\/span><\/a>\u00a0Ghosh S, Liu B, Wang Y, Hao Q, Zhou Z. <\/span>Cell Rep<\/span><\/i>. 2015 Nov 17;13(7):1396-1406. doi: 10.1016\/j.celrep.2015.10.006. Epub 2015 Nov 5. PMID: 26549451<\/span>\r\n

Sulforaphane\u00a0enhances\u00a0progerin clearance in Hutchinson-Gilford progeria fibroblasts.\r\n<\/a>Gabriel D, Roedl D, Gordon LB, Djabali K.\u00a0Aging Cell<\/i>. 2014 Dec 16: 1-14.<\/p>\r\n

Mechanisms\u00a0controlling\u00a0the\u00a0smooth muscle\u00a0cell death in progeria via down-regulation of poly(ADP-ribose) polymerase 1.\r\n<\/a>Zhang H, Xiong ZM, Cao K. Proc Natl Acad Sci<\/i> U S A. 2014 Jun 3;111(22):E2261-70. Epub 2014 May 19.<\/p>\r\n

Correlated\u00a0alterations\u00a0in\u00a0genome\u00a0organization,\u00a0histone\u00a0methylation, and DNA-lamin A\/C interactions in Hutchinson-Gilford progeria syndrome.\r\n<\/a>McCord RP, Nazario-Toole A, Zhang H, Chines PS, Zhan Y, Erdos MR, Collins FS, Dekker J, Cao K. Genome<\/i>\u00a0Res<\/i>. 2013 Feb;23(2):260-9. Epub 2012 Nov 14.<\/p>\r\n

An\u00a0inhibitory\u00a0role\u00a0of\u00a0progerin\u00a0in the gene induction network of adipocyte differentiation from iPS cells.\r\n<\/a>Xiong ZM, LaDana C, Wu D, Cao K. Aging<\/i> (Albany NY). 2013 Apr;5(4):288-303.<\/p>\r\n

Depleting\u00a0the\u00a0methyltransferase\u00a0Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.\r\n<\/a>Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z. Nat Commun<\/i>. 2013;4:1868.<\/p>\r\n

Na\u00efve\u00a0adult stem cells\u00a0from\u00a0patients\u00a0with\u00a0Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo.\r\n<\/a>Wenzel V, Roedl D, Gabriel D, Gordon LB, Herlyn M, Schneider R, Ring J, Djabali K.\r\nBiol Open.<\/i> 2012 Jun 15;1(6):516-26. Epub 2012 Apr 16.<\/p>\r\n

Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition.<\/a>Marji J, O'Donoghue SI, McClintock D, Satagopam VP, Schneider R, Ratner D, Worman HJ, Gordon LB, Djabali K. PLoS One<\/i>. 2010 Jun 15;5(6):e11132.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGADFN167<\/strong><\/p>\r\n

Smurf2\u00a0regulates\u00a0stability\u00a0and the autophagic-lysosomal turnover of lamin A and its disease-associated form progerin.\r\n<\/a>Borroni AP, Emanuelli A, Shah PA, Ili\u0107 N, Apel-Sarid L, Paolini B, Manikoth Ayyathan D, Koganti P, Levy-Cohen G, Blank M.\u00a0Aging Cell<\/em>. 2018 Feb 5. doi: 10.1111\/acel.12732. [Epub ahead of print].<\/p>\r\n

A\u00a0Cell-Intrinsic\u00a0Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.\r\n<\/a>Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S.\u00a0Cell Rep<\/em>. 2018 Feb 20;22(8):2006-2015.<\/p>\r\n

Identification\u00a0of\u00a0novel\u00a0PDE\u03b4 interacting proteins.\u00a0<\/a>K\u00fcchler P, Zimmermann G, Winzker M, Janning P, Waldmann H, Ziegler S.\u00a0Bioorg Med Chem<\/em>. 2017 Aug 31. pii: S0968-0896(17)31182-3. doi: 10.1016\/j.bmc.2017.08.033. [Epub ahead of print]<\/p>\r\n

Nucleolar\u00a0expansion\u00a0and\u00a0elevated\u00a0protein\u00a0translation in premature aging.\r\n<\/a>Buchwalter A, Hetzer MW.\r\nNat Commun. 2017 Aug 30;8(1):328. doi: 10.1038\/s41467-017-00322-z.<\/p>\r\n

Reprogramming\u00a0progeria\u00a0fibroblasts\u00a0re-establishes a normal epigenetic landscape.\u00a0<\/a>Chen Z, Chang WY, Etheridge A, Strickfaden H, Jin Z, Palidwor G, Cho JH, Wang K, Kwon SY, Dor\u00e9 C, Raymond A, Hotta A, Ellis J, Kandel RA, Dilworth FJ, Perkins TJ, Hendzel MJ, Galas DJ, Stanford WL. .Aging Cell<\/em>. 2017 Jun 8. [Epub ahead of print]<\/p>\r\n

Metformin\u00a0Alleviates\u00a0Aging\u00a0Cellular\u00a0Phenotypes in Hutchinson-Gilford Progeria Syndrome Dermal Fibroblasts.<\/a>\r\nPark SK, Shin OS.\r\nExp Dermatol<\/em>. 2017 Feb 13. [Epub ahead of print]<\/p>\r\n

Loss\u00a0of\u00a0H3K9me3\u00a0Correlates with ATM Activation and Histone H2AX Phosphorylation Deficiencies in Hutchinson-Gilford Progeria Syndrome.<\/a>\u00a0Zhang H, Sun L, Wang K, Wu D, Trappio M, Witting C, Cao K.\u00a0PLoS One<\/em>. 2016 Dec 1;11(12):e0167454. doi: 10.1371\/journal.pone.0167454.<\/p>\r\n

NANOG\u00a0reverses\u00a0the\u00a0Myogenic\u00a0Differentiation Potential of Senescent Stem Cells by Restoring ACTIN Filamentous Organization and SRF-Dependent Gene Expression.\u00a0<\/a>Mistriotis P, Bajpai VK, Wang X, Rong N, Shahini A, Asmani M, Liang MS, Wang J, Lei P, Liu S, Zhao R, Andreadis ST.\u00a0Stem Cells<\/em>. 2016 Jun 28. doi: 10.1002\/stem.2452. [Epub ahead of print]<\/p>\r\n

Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria.\r\n<\/a>Xiong ZM, Choi JY, Wang K, Zhang H, Tariq Z, Wu D, Ko E, LaDana C, Sesaki H, Cao K. Aging Cell.<\/i><\/a>\u00a0 2015 Dec 14. [Epub ahead of print]<\/p>\r\n

Insights\u00a0into the\u00a0role\u00a0of\u00a0immunosenescence\u00a0during varicella zoster virus infection (shingles) in the aging cell model.\r\n<\/a>Kim JA, Park SK, Kumar M, Lee CH, Shin OS. Oncotarget<\/i>. 2015 Oct 14. [Epub ahead of print]<\/p>\r\n

Proliferation\u00a0of\u00a0progeria\u00a0cells\u00a0is\u00a0enhanced\u00a0by\u00a0lamina-associated polypeptide 2\u03b1 (LAP2\u03b1) through expression of extracellular matrix proteins.\r\n<\/a>Vidak S, Kubben N, Dechat T, Foisner R. Genes & Development.<\/i> 2015 Oct 1;29(19):2022-36.<\/p>\r\n

Nuclear\u00a0stiffening\u00a0and\u00a0chromatin\u00a0softening with progerin expression leads to an attenuated nuclear\u00a0response to force.\r\n<\/a>Booth EA, Spagnol ST, Alcoser TA, Dahl KN. Soft Matter<\/i>. 2015 Aug 28;11(32):6412-8. Epub 2015 Jul 14.<\/p>\r\n

Phenotype-Dependent\u00a0Coexpression\u00a0Gene\u00a0Clusters: Application to Normal and Premature Ageing.\r\n<\/a>Wang K, Das A, Xiong Z,\u00a0 Cao K, Hannenhalli S. IEEE\/ACM Trans Comput Biol Bioinform<\/i> 2015 Jan-Feb;12(1):30-9.<\/p>\r\n

Mechanisms\u00a0controlling\u00a0the\u00a0smooth muscle\u00a0cell death in progeria via down-regulation of poly(ADP-ribose) polymerase 1.\r\n<\/a>Zhang H, Xiong ZM, Cao K.\u00a0Proc Natl Acad Sci<\/i>\u00a0U S A. 2014 Jun 3;111(22):E2261-70. Epub 2014 May 19.<\/p>\r\n

Higher-order\u00a0unfolding\u00a0of satellite heterochromatin is a consistent and early event in cell senescence.\r\n<\/a>Swanson EC, Manning B, Zhang H, Lawrence JB.\u00a0J Cell Biol<\/i>. 2013 Dec 23;203(6):929-42.<\/p>\r\n

Correlated\u00a0alterations\u00a0in\u00a0genome\u00a0organization,\u00a0histone\u00a0methylation, and DNA-lamin A\/C interactions in Hutchinson-Gilford progeria syndrome.\r\n<\/a>McCord RP, Nazario-Toole A, Zhang H, Chines PS, Zhan Y, Erdos MR, Collins FS, Dekker J, Cao K. Genome<\/i>\u00a0Res<\/i>. 2013 Feb;23(2):260-9. Epub 2012 Nov 14.<\/p>\r\n

Progeria:\u00a0translational\u00a0insights\u00a0from\u00a0cell biology.\r\n<\/a>Gordon LB, Cao K, Collins FS. J\u00a0Cell\u00a0Biol<\/i>. 2012 Oct 1;199(1):9-13. doi: 10.1083\/jcb.201207072.<\/p>\r\n

Automated\u00a0image\u00a0analysis\u00a0of\u00a0nuclear\u00a0shape: what can we\u00a0learn\u00a0from a prematurely aged cell?\r\n<\/a>Driscoll MK, Albanese JL, Xiong ZM, Mailman M, Losert W, Cao K. Aging<\/i> (Albany NY). 2012 Feb;4(2):119-32.<\/p>\r\n

Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders.<\/a>Choi\u00a0S,\u00a0Wang\u00a0W,\u00a0Ribeiro\u00a0AJ, Kalinowski A, Gregg SQ, Opresko PL, Niedernhofer LJ, Rohde GK, Dahl KN. Nucleus<\/i>. 2011 Nov 1;2(6):570-9. Epub 2011 Nov 1.<\/p>\r\n

Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells.<\/a>\r\nCao K, Graziotto JJ, Blair CD, Mazzulli JR, Erdos MR, Krainc D, Collins FS. Sci Transl Med.<\/em> 2011 Jun 29;3(89):89ra58.<\/p>\r\n

Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts.<\/a>\r\nCao K, Blair CD, Faddah DA, Kieckhaefer JE, Olive M, Erdos MR, Nabel EG, Collins FS. J Clin Invest.<\/em> 2011 Jul 1;121(7):2833-44<\/p>\r\n

CTP:phosphocholine cytidylyltransferase \u03b1 (CCT\u03b1) and lamins alter nuclear membrane structure without affecting phosphatidylcholine synthesis.<\/a>\r\nGehrig K, Ridgway ND. Biochim Biophys Acta<\/em>. 2011 Jun;1811(6):377-85.<\/p>\r\n

Effect of progerin on the accumulation of oxidized proteins in fibroblasts from Hutchinson Gilford progeria patients.<\/a>\r\nViteri G, Chung YW, Stadtman ER. Mech Ageing Dev<\/em>. 2010 Jan;131(1):2-8.<\/p>\r\n

A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells.<\/a>\r\nCao K, Capell BC, Erdos MR, Djabali K, Collins FS. Proc Natl Acad Sci USA<\/em>. 2007 Mar 20;104(12):4949-54.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGFDFN168<\/strong><\/p>\r\n

Smurf2\u00a0regulates\u00a0stability\u00a0and the autophagic-lysosomal turnover of lamin A and its disease-associated form progerin.\r\n<\/a>Borroni AP, Emanuelli A, Shah PA, Ili\u0107 N, Apel-Sarid L, Paolini B, Manikoth Ayyathan D, Koganti P, Levy-Cohen G, Blank M.\u00a0Aging Cell<\/em>. 2018 Feb 5. doi: 10.1111\/acel.12732. [Epub ahead of print].<\/span>\u00a0<\/span><\/p>\r\n

Nucleoplasmic\u00a0lamins\u00a0define\u00a0growth-regulating functions of lamina-associated polypeptide 2\u03b1 in progeria cells.<\/a>\u00a0Vidak S, Georgiou K, Fichtinger P, Naetar N, Dechat T, Foisner R. J Cell Sci. 2017 Dec 28. pii: jcs.208462. doi: 10.1242\/jcs.208462. [Epub ahead of print]<\/p>\r\n

Nucleolar\u00a0expansion\u00a0and\u00a0elevated\u00a0protein\u00a0translation in premature aging.<\/a>\u00a0Buchwalter A, Hetzer MW. Nat Commun. 2017 Aug 30;8(1):328. doi: 10.1038\/s41467-017-00322-z.<\/p>\r\n

Reprogramming\u00a0progeria\u00a0fibroblasts\u00a0re-establishes a normal epigenetic landscape.\u00a0<\/a>Chen Z, Chang WY, Etheridge A, Strickfaden H, Jin Z, Palidwor G, Cho JH, Wang K, Kwon SY, Dor\u00e9 C, Raymond A, Hotta A, Ellis J, Kandel RA, Dilworth FJ, Perkins TJ, Hendzel MJ, Galas DJ, Stanford WL. .Aging Cell<\/em>. 2017 Jun 8. [Epub ahead of print]<\/p>\r\n

Loss\u00a0of\u00a0H3K9me3\u00a0Correlates with ATM Activation and Histone H2AX Phosphorylation Deficiencies in Hutchinson-Gilford Progeria Syndrome.<\/a>\u00a0Zhang H, Sun L, Wang K, Wu D, Trappio M, Witting C, Cao K.\u00a0PLoS One<\/em>. 2016 Dec 1;11(12):e0167454. doi: 10.1371\/journal.pone.0167454.<\/p>\r\n

NANOG\u00a0reverses\u00a0the\u00a0Myogenic\u00a0Differentiation Potential of Senescent Stem Cells by Restoring ACTIN Filamentous Organization and SRF-Dependent Gene Expression.<\/a>Mistriotis P, Bajpai VK, Wang X, Rong N, Shahini A, Asmani M, Liang MS, Wang J, Lei P, Liu S, Zhao R, Andreadis ST.\u00a0Stem Cells<\/em>. 2016 Jun 28. doi: 10.1002\/stem.2452. [Epub ahead of print]<\/p>\r\n

Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria.\r\n<\/a>Xiong ZM, Choi JY, Wang K, Zhang H, Tariq Z, Wu D, Ko E, LaDana C, Sesaki H, Cao K.\u00a0Aging Cell.<\/i><\/a>\u00a0 2015 Dec 14. [Epub ahead of print]<\/p>\r\n

Proliferation\u00a0of\u00a0progeria\u00a0cells\u00a0is\u00a0enhanced\u00a0by\u00a0lamina-associated polypeptide 2\u03b1 (LAP2\u03b1) through expression of extracellular matrix proteins.\r\n<\/a>Vidak S, Kubben N, Dechat T, Foisner R. Genes & Development.<\/i> 2015 Oct 1;29(19):2022-36.<\/p>\r\n

Nuclear\u00a0stiffening\u00a0and\u00a0chromatin\u00a0softening with progerin expression leads to an attenuated nuclear\u00a0response to force.\r\n<\/a>Booth EA, Spagnol ST, Alcoser TA, Dahl KN. Soft Matter<\/i>. 2015 Aug 28;11(32):6412-8. Epub 2015 Jul 14.<\/p>\r\n

Phenotype-Dependent\u00a0Coexpression\u00a0Gene\u00a0Clusters: Application to Normal and Premature Ageing.\r\n<\/a>Wang K, Das A, Xiong Z,\u00a0 Cao K, Hannenhalli S. IEEE\/ACM Trans Comput Biol Bioinform<\/i> 2015 Jan-Feb;12(1):30-9.<\/p>\r\n

Mechanisms\u00a0controlling\u00a0the\u00a0smooth muscle\u00a0cell death in progeria via down-regulation of poly(ADP-ribose) polymerase 1.\r\n<\/a>Zhang H, Xiong ZM, Cao K.\u00a0Proc Natl Acad Sci<\/i>\u00a0U S A. 2014 Jun 3;111(22):E2261-70. Epub 2014 May 19.<\/p>\r\n

Correlated\u00a0alterations\u00a0in\u00a0genome\u00a0organization,\u00a0histone\u00a0methylation, and DNA-lamin A\/C interactions in Hutchinson-Gilford progeria syndrome.\r\n<\/a>McCord RP, Nazario-Toole A, Zhang H, Chines PS, Zhan Y, Erdos MR, Collins FS, Dekker J, Cao K. Genome<\/i>\u00a0Res<\/i>. 2013 Feb;23(2):260-9. Epub 2012 Nov 14.<\/p>\r\n

Automated\u00a0image\u00a0analysis\u00a0of\u00a0nuclear\u00a0shape: what can we\u00a0learn\u00a0from a prematurely aged cell?\r\n<\/a>Driscoll MK, Albanese JL, Xiong ZM, Mailman M, Losert W, Cao K. Aging<\/i> (Albany NY). 2012 Feb;4(2):119-32.<\/p>\r\n

Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders.\r\n<\/a>Choi\u00a0S,\u00a0Wang\u00a0W,\u00a0Ribeiro\u00a0AJ, Kalinowski A, Gregg SQ, Opresko PL, Niedernhofer LJ, Rohde GK, Dahl KN. Nucleus<\/i>. 2011 Nov 1;2(6):570-9. Epub 2011 Nov 1.<\/p>\r\n

Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells.<\/a>\r\nCao K, Graziotto JJ, Blair CD, Mazzulli JR, Erdos MR, Krainc D, Collins FS. Sci Transl Med.<\/em> 2011 Jun 29;3(89):89ra58.<\/p>\r\n

Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts.<\/a>\r\nCao K, Blair CD, Faddah DA, Kieckhaefer JE, Olive M, Erdos MR, Nabel EG, Collins FS. J Clin Invest<\/em>.<\/em> 2011 Jul 1;121(7):2833-44<\/p>\r\n

Effect of progerin on the accumulation of oxidized proteins in fibroblasts from Hutchinson Gilford progeria patients.<\/a>\r\nViteri G, Chung YW, Stadtman ER. Mech Ageing Dev<\/em>. 2010 Jan;131(1):2-8.<\/p>\r\n

A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells.<\/a>\r\nCao K, Capell BC, Erdos MR, Djabali K, Collins FS. Proc Natl Acad Sci USA<\/em>. 2007 Mar 20;104(12):4949-54.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGADFN169<\/strong><\/p>\r\n

Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria.\r\n<\/a>Xiong ZM, Choi JY, Wang K, Zhang H, Tariq Z, Wu D, Ko E, LaDana C, Sesaki H, Cao K.\u00a0Aging Cell.<\/i><\/a>\u00a0 2015 Dec 14. [Epub ahead of print]<\/p>\r\nLamin A\u00a0Is an\u00a0Endogenous\u00a0SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair.<\/span><\/a>\u00a0Ghosh S, Liu B, Wang Y, Hao Q, Zhou Z. <\/span>Cell Rep<\/span><\/i>. 2015 Nov 17;13(7):1396-1406. doi: 10.1016\/j.celrep.2015.10.006. Epub 2015 Nov 5. PMID:26549451<\/span>\r\n

Correlated\u00a0alterations\u00a0in\u00a0genome\u00a0organization,\u00a0histone\u00a0methylation, and DNA-lamin A\/C interactions in Hutchinson-Gilford progeria syndrome.\r\n<\/a>McCord RP, Nazario-Toole A, Zhang H, Chines PS, Zhan Y, Erdos MR, Collins FS, Dekker J, Cao K. Genome<\/i>\u00a0Res<\/i>. 2013 Feb;23(2):260-9. Epub 2012 Nov 14.<\/p>\r\n

Depleting\u00a0the\u00a0methyltransferase\u00a0Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.\r\n<\/a>Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z. Nat Commun<\/i>. 2013;4:1868.<\/p>\r\n

Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells.\r\n<\/a>[sta_anchor id=\"fn178\" unsan=\"FN178\"]Cao K, Graziotto JJ, Blair CD, Mazzulli JR, Erdos MR, Krainc D, Collins FS. Sci Transl Med.<\/i> 2011 Jun 29;3(89):89ra58.[\/sta_anchor]<\/p>\r\n\r\n\r\n

\r\n

HGADFN178<\/b><\/p>\r\n

Na\u00efve\u00a0adult stem cells\u00a0from\u00a0patients\u00a0with\u00a0Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo.\r\n<\/a>Wenzel V, Roedl D, Gabriel D, Gordon LB, Herlyn M, Schneider R, Ring J, Djabali K.\r\nBiol Open.<\/i> 2012 Jun 15;1(6):516-26. Epub 2012 Apr 16.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGADFN188<\/strong><\/p>\r\n

p53\u00a0isoforms\u00a0regulate\u00a0premature aging\u00a0in\u00a0human\u00a0cells.\r\n<\/a>von Muhlinen N, Horikawa I, Alam F, Isogaya K, Lissa D, Vojtesek B, Lane DP, Harris CC.\r\nOncogene<\/em>. 2018 Feb 12. doi: 10.1038\/s41388-017-0101-3. [Epub ahead of print]<\/p>\r\n

Sulforaphane\u00a0enhances\u00a0progerin clearance in Hutchinson-Gilford progeria fibroblasts.\r\n<\/a>Gabriel D, Roedl D, Gordon LB, Djabali K. Aging Cell<\/i>. 2014 Dec 16: 1-14.<\/p>\r\n

Depleting\u00a0the\u00a0methyltransferase\u00a0Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.\r\n<\/a>Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z. Nat Commun<\/i>. 2013;4:1868.<\/p>\r\n

Na\u00efve\u00a0adult stem cells\u00a0from\u00a0patients\u00a0with\u00a0Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo.\r\n<\/a>Wenzel V, Roedl D, Gabriel D, Gordon LB, Herlyn M, Schneider R, Ring J, Djabali K.\r\nBiol Open.<\/i> 2012 Jun 15;1(6):516-26. Epub 2012 Apr 16.<\/p>\r\n

Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition.<\/a>\r\nMarji J, O'Donoghue SI, McClintock D, Satagopam VP, Schneider R, Ratner D, Worman HJ, Gordon LB, Djabali K. PLoS One<\/em>. 2010 Jun 15;5(6):e11132.<\/p>\r\n\r\n\r\n

\r\n

<\/a>PSADFN257<\/strong><\/p>\r\nA\u00a0Cell-Intrinsic\u00a0Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.\r\n<\/a>Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S.\u00a0Cell Rep<\/em>. 2018 Feb 20;22(8):2006-2015.\r\n\r\n

\r\n

<\/a>PSFDFN319<\/strong><\/p>\r\n

Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells.<\/a>\r\nCao K, Graziotto JJ, Blair CD, Mazzulli JR, Erdos MR, Krainc D, Collins FS. Sci Transl Med.<\/em> 2011 Jun 29;3(89):89ra58.<\/p>\r\n\r\n\r\n

\r\n

<\/a>PSMDFN320<\/strong><\/p>\r\n

Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells.<\/a>\r\nCao K, Graziotto JJ, Blair CD, Mazzulli JR, Erdos MR, Krainc D, Collins FS. Sci Transl Med.<\/em> 2011 Jun 29;3(89):89ra58.<\/p>\r\n\r\n\r\n

\r\n

<\/a>PSADFN327<\/strong><\/p>\r\n

A\u00a0Cell-Intrinsic\u00a0Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.\r\n<\/a>Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S.\u00a0Cell Rep<\/em>. 2018 Feb 20;22(8):2006-2015.<\/p>\r\n\r\n\r\n

\r\n

<\/a>PSMDFN346<\/strong><\/p>\r\nA\u00a0Cell-Intrinsic\u00a0Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.\r\n<\/a>Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S.\u00a0Cell Rep<\/em>. 2018 Feb 20;22(8):2006-2015.\r\n\r\n

\r\n

<\/a>PSADFN392<\/strong><\/p>\r\nA\u00a0Cell-Intrinsic\u00a0Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.\r\n<\/a>Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S.\u00a0Cell Rep<\/em>. 2018 Feb 20;22(8):2006-2015.\r\n\r\n

\r\n

<\/a>HGALBV009<\/strong><\/p>\r\n

Stem cell depletion in Hutchinson-Gilford progeria syndrome.<\/a>\r\nRosengardten Y, McKenna T, Grochov\u00e1 D, Eriksson M. Aging Cell.<\/em> 2011 Dec;10(6):1011-20. Epub 2011 Oct 11.<\/p>\r\n

Low and high expressing alleles of the LMNA gene: implications for laminopathy disease development.<\/a>\r\nRodr\u00edguez S, Eriksson M. PLoS One.<\/em> 2011;6(9):e25472. Epub 2011 Sep 29.<\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGMLBV010<\/strong><\/p>\r\n

Stem cell depletion in Hutchinson-Gilford progeria syndrome.<\/a>\r\nRosengardten Y, McKenna T, Grochov\u00e1 D, Eriksson M. Aging Cell.<\/em> 2011 Dec;10(6):1011-20. Epub 2011 Oct 11.<\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGALBV011<\/strong><\/p>\r\n

Low and high expressing alleles of the LMNA gene: implications for laminopathy disease development.<\/a>\r\nRodr\u00edguez S, Eriksson M. PL<\/em>oS One.<\/em> 2011;6(9):e25472. Epub 2011 Sep 29.<\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGMLBV013<\/strong><\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGFLBV021<\/strong><\/p>\r\n

Stem cell depletion in Hutchinson-Gilford progeria syndrome.<\/a>\r\nRosengardten Y, McKenna T, Grochov\u00e1 D, Eriksson M. Aging Cell.<\/em> 2011 Dec;10(6):1011-20. Epub 2011 Oct 11.<\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGMLBV023<\/strong><\/p>\r\n

Stem cell depletion in Hutchinson-Gilford progeria syndrome.<\/a>\r\nRosengardten Y, McKenna T, Grochov\u00e1 D, Eriksson M. Aging Cell.<\/em> 2011 Dec;10(6):1011-20. Epub 2011 Oct 11.<\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGFLBV031<\/strong><\/p>\r\n

Stem cell depletion in Hutchinson-Gilford progeria syndrome.<\/a>\r\nRosengardten Y, McKenna T, Grochov\u00e1 D, Eriksson M. Aging Cell.<\/em> 2011 Dec;10(6):1011-20. Epub 2011 Oct 11.<\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGFLBV050<\/strong><\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGALBV057<\/strong><\/p>\r\n

Stem cell depletion in Hutchinson-Gilford progeria syndrome.<\/a>\r\nRosengardten Y, McKenna T, Grochov\u00e1 D, Eriksson M. Aging Cell.<\/em> 2011 Dec;10(6):1011-20. Epub 2011 Oct 11.<\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGMLBV058<\/strong><\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGSLBV059<\/strong><\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.\u00a0<\/strong><\/p>\r\n\r\n\r\n

\r\n

\u00a0 <\/a>HGMLBV066<\/strong><\/p>\r\n

Stem cell depletion in Hutchinson-Gilford progeria syndrome.<\/a>\r\nRosengardten Y, McKenna T, Grochov\u00e1 D, Eriksson M. Aging Cell.<\/em> 2011 Dec;10(6):1011-20. Epub 2011 Oct 11.<\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGFLBV067<\/strong><\/p>\r\n

Stem cell depletion in Hutchinson-Gilford progeria syndrome.<\/a>\r\nRosengardten Y, McKenna T, Grochov\u00e1 D, Eriksson M. Aging Cell.<\/em> 2011 Dec;10(6):1011-20. doi: 10.1111\/j.1474-9726.2011.00743.x. Epub 2011 Oct 11.<\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\r\n\r\n\r\n

\r\n

<\/a><\/a>HGALBV071<\/strong><\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGMLBV081<\/strong><\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGFLBV082<\/strong><\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\r\n[\/vc_column_text][\/vc_column][\/vc_row]\t\t","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-1012","page","type-page","status-publish","hentry"],"yoast_head":"\nCell publications | The Progeria Research Foundation<\/title>\n<meta name=\"description\" content=\"The Progeria Research Foundation Cell and Tissue Bank has contributed to the following Cell and Tissue Bank publications.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.progeriaresearch.org\/it\/prf-cell-and-tissue-bank-publications\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cell publications | The Progeria Research Foundation\" \/>\n<meta property=\"og:description\" content=\"The Progeria Research Foundation Cell and Tissue 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