{"id":2047,"date":"2011-05-16T12:31:46","date_gmt":"2011-05-16T12:31:46","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?p=2047"},"modified":"2020-12-10T17:54:48","modified_gmt":"2020-12-10T22:54:48","slug":"groundbreaking-study-on-progeria-aging-link","status":"publish","type":"post","link":"https:\/\/www.progeriaresearch.org\/it\/2011\/05\/16\/groundbreaking-study-on-progeria-aging-link\/","title":{"rendered":"Studio rivoluzionario sul legame tra progeria e invecchiamento"},"content":{"rendered":"<p>Italiano: [et_pb_section fb_built=\u201d1\u2033 _builder_version=\u201d3.22\u2033][et_pb_row _builder_version=\u201d3.25\u2033 background_size=\u201diniziale\u201d background_position=\u201dtop_left\u201d background_repeat=\u201dripeti\u201d][et_pb_column type=\u201d4_4\u2033 _builder_version=\u201d3.25\u2033 custom_padding=\u201d|||\u201d custom_padding__hover=\u201d|||\u201d][et_pb_text _builder_version=\u201d4.6.5\u2033 background_size=\u201diniziale\u201d background_position=\u201dtop_left\u201d background_repeat=\u201dripeti\u201d hover_enabled=\u201d0\u2033 sticky_enabled=\u201d0\u2033]<\/p>\n<p>L&#039;affascinante legame tra Progeria e invecchiamento continua a rafforzarsi, poich\u00e9 i ricercatori del NIH hanno scoperto un collegamento tra telomeri e progerina.<\/p>\n<p class=\"yiv314624100msonormal\"><a href=\"https:\/\/www.cbsnews.com\/news\/clues-about-how-we-age-found-in-genetic-disorder\/\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-2052\" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2017\/05\/Capture.png\" alt=\"\" width=\"427\" height=\"279\" srcset=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2017\/05\/Capture.png 427w, https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2017\/05\/Capture-300x196.png 300w\" sizes=\"(max-width: 427px) 100vw, 427px\" \/><\/a>I ricercatori del National Institutes of Health hanno scoperto un legame finora sconosciuto tra Progeria e invecchiamento. I risultati forniscono informazioni sulla relazione tra la proteina tossica che causa la Progeria, nota come <strong>progerina <\/strong>E <strong>telomeri<\/strong>, che proteggono le estremit\u00e0 del DNA all&#039;interno delle cellule finch\u00e9 non si consumano nel tempo e le cellule muoiono.<\/p>\n<p class=\"yiv314624100msonormal\">Lo studio* \u00e8 apparso nell&#039;edizione online anticipata del 13 giugno 2011 del Journal of Clinical Investigation. Conclude che nell&#039;invecchiamento normale, i telomeri corti o disfunzionali stimolano le cellule a produrre progerina, che \u00e8 associata a danni cellulari correlati all&#039;et\u00e0.<\/p>\n<div id=\"attachment_2048\" style=\"width: 410px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-2048\" class=\"wp-image-2048 size-full\" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2017\/05\/panel.jpg\" alt=\"\" width=\"400\" height=\"159\" srcset=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2017\/05\/panel.jpg 400w, https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2017\/05\/panel-300x119.jpg 300w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><p id=\"caption-attachment-2048\" class=\"wp-caption-text\">Le cellule che esprimono progerina da individui normali mostrano segni di senescenza. Il DNA nel nucleo \u00e8 colorato di blu. I telomeri sono visti come puntini rossi.<\/p><\/div>\n<p class=\"yiv314624100msonormal\">\u201c<strong>Per la prima volta, sappiamo che l&#039;accorciamento e la disfunzione dei telomeri influenzano la produzione di progerina&quot;, afferma Leslie B. Gordon, MD, PhD, Direttore medico della Progeria Research Foundation. &quot;Quindi questi due processi, entrambi influenzanti l&#039;invecchiamento cellulare, sono in realt\u00e0 collegati&quot;.<\/strong><\/p>\n<p class=\"yiv314624100msonormal\">Ricerche precedenti hanno dimostrato che la progerina non \u00e8 prodotta solo nei bambini con Progeria, ma che \u00e8 prodotta in quantit\u00e0 minori in tutti noi, e i livelli di progerina aumentano con l&#039;invecchiamento. Indipendentemente, ricerche precedenti sull&#039;accorciamento e la disfunzione dei telomeri sono state associate al normale invecchiamento. Dal 2003, con la scoperta della mutazione genetica della Progeria e della proteina progerina che causa la malattia, una delle aree chiave della ricerca si \u00e8 concentrata sulla comprensione se e come la Progeria e l&#039;invecchiamento siano collegati.<\/p>\n<p class=\"yiv314624100msonormal\">&quot;Collegare questo raro fenomeno di malattia e il normale invecchiamento sta dando i suoi frutti in modo importante&quot;, ha affermato il direttore del NIH Francis S. Collins, MD, PhD, autore senior del documento. &quot;Questo studio evidenzia che si ottengono preziose intuizioni biologiche studiando rari disturbi genetici come la Progeria. Fin dall&#039;inizio, avevamo la sensazione che la Progeria avesse molto da insegnarci sul normale processo di invecchiamento&quot;.<\/p>\n<p class=\"yiv314624100msoplaintext\">Gli scienziati hanno tradizionalmente studiato separatamente i telomeri e la progerina. Sebbene ci sia ancora molto da imparare sul fatto che questa nuova connessione possa portare a una cura per i bambini con la Progeria o essere potenzialmente applicata per estendere la durata della vita umana, questo studio fornisce ulteriori prove che la progerina, la proteina tossica scoperta tramite la scoperta della mutazione genetica nella Progeria, svolge un ruolo nel normale processo di invecchiamento.<\/p>\n<p class=\"yiv314624100msoplaintext justifyleft\">*<em>La progerina e la disfunzione dei telomeri collaborano per innescare la senescenza cellulare nei fibroblasti umani normali<\/em>, Cao e altri, <em>Investimento J Clin <\/em>doi:10.1172\/JCI43578.<\/p>\n<p class=\"yiv314624100msoplaintext\"><a href=\"https:\/\/www.progeriaresearch.org\/it\/assets\/files\/pdf\/psa_ads\/NIH%20Press%20Release.pdf\/\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/web.archive.org\/web\/20170216015614im_\/https:\/\/www.progeriaresearch.org\/assets\/images\/iconPDF.gif\" alt=\"\" width=\"34\" height=\"20\" \/>clicca qui<\/a> per il testo completo del comunicato stampa del NIH.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"<p>Italiano: [et_pb_section fb_built=\u201d1\u2033 _builder_version=\u201d3.22\u2033][et_pb_row _builder_version=\u201d3.25\u2033 background_size=\u201diniziale\u201d background_position=\u201dtop_left\u201d background_repeat=\u201dripeti\u201d][et_pb_column type=\u201d4_4\u2033 _builder_version=\u201d3.25\u2033 custom_padding=\u201d|||\u201d custom_padding__hover=\u201d|||\u201d][et_pb_text _builder_version=\u201d4.6.5\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201drepeat\u201d hover_enabled=\u201d0\u2033 sticky_enabled=\u201d0\u2033] L&#039;affascinante legame tra Progeria e invecchiamento continua a rafforzarsi, poich\u00e9 i ricercatori del NIH hanno scoperto un collegamento tra telomeri e progerina. I ricercatori del National Institutes of Health hanno scoperto un collegamento precedentemente sconosciuto tra Progeria e invecchiamento. I risultati forniscono approfondimenti [\u2026]<\/p>","protected":false},"author":1,"featured_media":2048,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"<p>[vc_custom_heading text=\"Groundbreaking Study on Progeria-Aging Link\" font_container=\"tag:h1|text_align:left\" use_theme_fonts=\"yes\"]<\/p><div id=\"secondary-header-content\"><p>The captivating connection between Progeria and aging continues to strengthen, as NIH researchers find link between telomeres and progerin.<\/p><\/div><p class=\"yiv314624100msonormal\"><a href=\"https:\/\/www.cbsnews.com\/news\/clues-about-how-we-age-found-in-genetic-disorder\/\"><img class=\"aligncenter size-full wp-image-2052\" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2017\/05\/Capture.png\" alt=\"\" width=\"427\" height=\"279\" \/><\/a>National Institutes of Health researchers have discovered a previously unknown link between Progeria and aging.\u00a0 The findings provide insights about the relationship between the toxic, Progeria-causing protein known as <strong>progerin <\/strong>and <strong>telomeres<\/strong>, which protect the ends of DNA within cells until they wear away over time and the cells die.<\/p><p class=\"yiv314624100msonormal\">The study* appears in the June 13, 2011 early online edition of the Journal of Clinical Investigation. It concludes that in normal aging, short or dysfunctional telomeres stimulate cells to produce progerin, which is associated with age-related cell damage.<\/p>[caption id=\"attachment_2048\" align=\"aligncenter\" width=\"400\"]<img class=\"wp-image-2048 size-full\" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2017\/05\/panel.jpg\" alt=\"\" width=\"400\" height=\"159\" \/> Progerin-expressing cells from normal individuals show signs of senescence. DNA in the nucleus is stained blue. Telomeres are seen as red dots.[\/caption]<p class=\"yiv314624100msonormal\">\"<strong>For the first time, we know that telomere shortening and dysfunction influences the production of progerin,\" says The Progeria Research Foundation Medical Director Leslie B. Gordon, MD, PhD. \"Thus these two processes, both of which influence cellular aging, are actually linked.\"<\/strong><\/p><p class=\"yiv314624100msonormal\">Prior research has shown that progerin is not only produced in children with Progeria, but that it is produced in smaller amounts in all of us, and progerin levels increase with aging. Independently, previous research on telomere shortening and dysfunction has been associated with normal aging. Since 2003, with the discovery of the Progeria gene mutation and the progerin protein that causes the disease, one of the key areas of research has focused on understanding whether and how Progeria and aging are linked.<\/p><p class=\"yiv314624100msonormal\">\"Connecting this rare disease phenomenon and normal aging is bearing fruit in an important way,\" said NIH Director Francis S. Collins, MD, PhD, a senior author of the paper. \"This study highlights that valuable biological insights are gained by studying rare genetic disorders such as Progeria. Our sense from the start was that Progeria had a lot to teach us about the normal aging process. \"<\/p><p class=\"yiv314624100msoplaintext\">Scientists have traditionally studied telomeres and progerin separately. While there is still much to learn about whether this new connection can lead to a cure for children with Progeria or potentially be applied to extending the human lifespan, this study provides further evidence that progerin, the toxic protein discovered through finding the gene mutation in Progeria, plays a role in the normal aging process.<\/p><p class=\"yiv314624100msoplaintext justifyleft\">*<em>Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts<\/em>, Cao et al, <em>J Clin Invest <\/em>doi:10.1172\/JCI43578.<\/p><p class=\"yiv314624100msoplaintext\"><a href=\"https:\/\/www.progeriaresearch.org\/assets\/files\/pdf\/psa_ads\/NIH%20Press%20Release.pdf\"><img src=\"https:\/\/web.archive.org\/web\/20170216015614im_\/https:\/\/www.progeriaresearch.org\/assets\/images\/iconPDF.gif\" alt=\"\" width=\"34\" height=\"20\" \/>Click here<\/a> for the full text of the NIH press release.<\/p>","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-2047","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Groundbreaking Study on Progeria-Aging Link - The Progeria Research Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.progeriaresearch.org\/it\/2011\/05\/16\/groundbreaking-study-on-progeria-aging-link\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Groundbreaking Study on Progeria-Aging Link - The Progeria Research Foundation\" \/>\n<meta property=\"og:description\" content=\"[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;3.22&#8243;][et_pb_row _builder_version=&#8221;3.25&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.6.5&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;] The captivating connection between Progeria and aging continues to strengthen, as NIH researchers find link between telomeres and progerin. National Institutes of Health researchers have discovered a previously unknown link between Progeria and aging.\u00a0 The findings provide insights [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.progeriaresearch.org\/it\/2011\/05\/16\/groundbreaking-study-on-progeria-aging-link\/\" \/>\n<meta property=\"og:site_name\" content=\"The Progeria Research Foundation\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ProgeriaResearch\/\" \/>\n<meta property=\"article:published_time\" content=\"2011-05-16T12:31:46+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-12-10T22:54:48+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2017\/05\/panel.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"159\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"gravoc\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@Progeria\" \/>\n<meta name=\"twitter:site\" content=\"@Progeria\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"gravoc\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.progeriaresearch.org\/ur\/2011\/05\/16\/groundbreaking-study-on-progeria-aging-link\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/ur\/2011\/05\/16\/groundbreaking-study-on-progeria-aging-link\/\"},\"author\":{\"name\":\"gravoc\",\"@id\":\"https:\/\/www.progeriaresearch.org\/ta\/#\/schema\/person\/a3c935a81e92242c6a77ae0018542928\"},\"headline\":\"Groundbreaking Study on Progeria-Aging Link\",\"datePublished\":\"2011-05-16T12:31:46+00:00\",\"dateModified\":\"2020-12-10T22:54:48+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/ur\/2011\/05\/16\/groundbreaking-study-on-progeria-aging-link\/\"},\"wordCount\":488,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/ta\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/ur\/2011\/05\/16\/groundbreaking-study-on-progeria-aging-link\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2017\/05\/panel.jpg\",\"articleSection\":[\"News\"],\"inLanguage\":\"it-IT\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.progeriaresearch.org\/ur\/2011\/05\/16\/groundbreaking-study-on-progeria-aging-link\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.progeriaresearch.org\/ur\/2011\/05\/16\/groundbreaking-study-on-progeria-aging-link\/\",\"url\":\"https:\/\/www.progeriaresearch.org\/ur\/2011\/05\/16\/groundbreaking-study-on-progeria-aging-link\/\",\"name\":\"Groundbreaking Study on Progeria-Aging Link - 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The Progeria Research Foundation","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.progeriaresearch.org\/it\/2011\/05\/16\/groundbreaking-study-on-progeria-aging-link\/","og_locale":"it_IT","og_type":"article","og_title":"Groundbreaking Study on Progeria-Aging Link - The Progeria Research Foundation","og_description":"[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;3.22&#8243;][et_pb_row _builder_version=&#8221;3.25&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.6.5&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;] The captivating connection between Progeria and aging continues to strengthen, as NIH researchers find link between telomeres and progerin. National Institutes of Health researchers have discovered a previously unknown link between Progeria and aging.\u00a0 The findings provide insights [&hellip;]","og_url":"https:\/\/www.progeriaresearch.org\/it\/2011\/05\/16\/groundbreaking-study-on-progeria-aging-link\/","og_site_name":"The Progeria Research Foundation","article_publisher":"https:\/\/www.facebook.com\/ProgeriaResearch\/","article_published_time":"2011-05-16T12:31:46+00:00","article_modified_time":"2020-12-10T22:54:48+00:00","og_image":[{"width":400,"height":159,"url":"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2017\/05\/panel.jpg","type":"image\/jpeg"}],"author":"gravoc","twitter_card":"summary_large_image","twitter_creator":"@Progeria","twitter_site":"@Progeria","twitter_misc":{"Written by":"gravoc","Est. reading time":"2 minuti"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.progeriaresearch.org\/ur\/2011\/05\/16\/groundbreaking-study-on-progeria-aging-link\/#article","isPartOf":{"@id":"https:\/\/www.progeriaresearch.org\/ur\/2011\/05\/16\/groundbreaking-study-on-progeria-aging-link\/"},"author":{"name":"gravoc","@id":"https:\/\/www.progeriaresearch.org\/ta\/#\/schema\/person\/a3c935a81e92242c6a77ae0018542928"},"headline":"Groundbreaking Study on Progeria-Aging Link","datePublished":"2011-05-16T12:31:46+00:00","dateModified":"2020-12-10T22:54:48+00:00","mainEntityOfPage":{"@id":"https:\/\/www.progeriaresearch.org\/ur\/2011\/05\/16\/groundbreaking-study-on-progeria-aging-link\/"},"wordCount":488,"commentCount":0,"publisher":{"@id":"https:\/\/www.progeriaresearch.org\/ta\/#organization"},"image":{"@id":"https:\/\/www.progeriaresearch.org\/ur\/2011\/05\/16\/groundbreaking-study-on-progeria-aging-link\/#primaryimage"},"thumbnailUrl":"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2017\/05\/panel.jpg","articleSection":["News"],"inLanguage":"it-IT","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.progeriaresearch.org\/ur\/2011\/05\/16\/groundbreaking-study-on-progeria-aging-link\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.progeriaresearch.org\/ur\/2011\/05\/16\/groundbreaking-study-on-progeria-aging-link\/","url":"https:\/\/www.progeriaresearch.org\/ur\/2011\/05\/16\/groundbreaking-study-on-progeria-aging-link\/","name":"Groundbreaking Study on Progeria-Aging Link - 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