{"id":790,"date":"2017-02-26T19:12:39","date_gmt":"2017-02-26T19:12:39","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?page_id=790"},"modified":"2026-03-17T11:43:56","modified_gmt":"2026-03-17T15:43:56","slug":"lonafarnib-pre-clinical-drug-supply-program","status":"publish","type":"page","link":"https:\/\/www.progeriaresearch.org\/kk\/lonafarnib-pre-clinical-drug-supply-program\/","title":{"rendered":"\u041b\u043e\u043d\u0430\u0444\u0430\u0440\u043d\u0438\u0431 \u043a\u043b\u0438\u043d\u0438\u043a\u0430\u0493\u0430 \u0434\u0435\u0439\u0456\u043d\u0433\u0456 \u0434\u04d9\u0440\u0456-\u0434\u04d9\u0440\u043c\u0435\u043a\u043f\u0435\u043d \u049b\u0430\u043c\u0442\u0430\u043c\u0430\u0441\u044b\u0437 \u0435\u0442\u0443 \u0431\u0430\u0493\u0434\u0430\u0440\u043b\u0430\u043c\u0430\u0441\u044b"},"content":{"rendered":"<p>[et_pb_section fb_built=\u201d1\u2033 fullwidth=\u201don\u201d disabled_on=\u201doff|off|off\u201d _builder_version=\u201d4.16\u2033 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srcset=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/Zoey-at-hospital-JAN-13-2014-1-261x300.jpg 261w, https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/Zoey-at-hospital-JAN-13-2014-1.jpg 497w\" sizes=\"(max-width: 261px) 100vw, 261px\" \/>PRF \u0444\u0430\u0440\u043d\u0435\u0437\u0438\u043b\u0442\u0440\u0430\u043d\u0441\u0444\u0435\u0440\u0430\u0437\u0430 \u0438\u043d\u0433\u0438\u0431\u0438\u0442\u043e\u0440\u044b\u043d, \u043b\u043e\u043d\u0430\u0444\u0430\u0440\u043d\u0438\u0431\u0442\u0456 \u0437\u0435\u0440\u0442\u0442\u0435\u0443 \u049b\u0430\u0443\u044b\u043c\u0434\u0430\u0441\u0442\u044b\u0493\u044b\u043d\u0430 \u049b\u043e\u043b\u0436\u0435\u0442\u0456\u043c\u0434\u0456 \u0435\u0442\u0435\u0434\u0456. \u0411\u0456\u0437\u0434\u0456\u04a3 \u043c\u0430\u049b\u0441\u0430\u0442\u044b\u043c\u044b\u0437 - \u043b\u043e\u043d\u0430\u0444\u0430\u0440\u043d\u0438\u0431\u0442\u0456\u04a3 \u041f\u0440\u043e\u0433\u0435\u0440\u0438\u044f\u0493\u0430 \u04d9\u0441\u0435\u0440\u0456\u043d \u043e\u0434\u0430\u043d \u04d9\u0440\u0456 \u0437\u0435\u0440\u0442\u0442\u0435\u0443 \u04af\u0448\u0456\u043d \u043a\u043b\u0438\u043d\u0438\u043a\u0430\u0493\u0430 \u0434\u0435\u0439\u0456\u043d\u0433\u0456 \u0437\u0435\u0440\u0442\u0442\u0435\u0443\u043b\u0435\u0440\u0433\u0435 \u049b\u043e\u043b\u0434\u0430\u0443 \u043a\u04e9\u0440\u0441\u0435\u0442\u0443.<\/p>\n<p>\u0411\u04b1\u043b PRF-\u0442\u0456\u04a3 \u043f\u0440\u043e\u0433\u0435\u0440\u0438\u044f\u0441\u044b \u0431\u0430\u0440 \u0431\u0430\u043b\u0430\u043b\u0430\u0440\u0434\u044b \u0435\u043c\u0434\u0435\u0443\u0434\u0456\u04a3 \u0436\u0430\u049b\u0441\u044b \u04d9\u0434\u0456\u0441\u0442\u0435\u0440\u0456\u043d \u0436\u04d9\u043d\u0435 \u0435\u043c\u0434\u0435\u043b\u0443\u0456\u043d \u0442\u0430\u0431\u0443\u0434\u044b\u04a3 \u0442\u04b1\u0440\u0430\u049b\u0442\u044b \u043c\u0438\u0441\u0441\u0438\u044f\u0441\u044b. \u041b\u043e\u043d\u0430\u0444\u0430\u0440\u043d\u0438\u0431 \u043a\u043b\u0438\u043d\u0438\u043a\u0430\u043b\u044b\u049b \u0442\u04b1\u0440\u0493\u044b\u0434\u0430\u043d \u0430\u0443\u0440\u0443\u0434\u044b\u04a3 \u043a\u0435\u0439\u0431\u0456\u0440 \u0430\u0441\u043f\u0435\u043a\u0442\u0456\u043b\u0435\u0440\u0456\u043d\u0435 \u043f\u0430\u0439\u0434\u0430\u0441\u044b\u043d \u0442\u0438\u0433\u0456\u0437\u0435\u0434\u0456 (\u0413\u043e\u0440\u0434\u043e\u043d \u0436\u04d9\u043d\u0435 \u0431\u0430\u0441\u049b\u0430\u043b\u0430\u0440, PNAS, 2012), \u0441\u043e\u043d\u0434\u0430\u0439-\u0430\u049b \u04e9\u043c\u0456\u0440 \u0441\u04af\u0440\u0443 \u04b1\u0437\u0430\u049b\u0442\u044b\u0493\u044b\u043d \u0430\u0440\u0442\u0442\u044b\u0440\u0430\u0434\u044b (Gordon et al, Circulation, 2014) (Gordon et al, JAMA, 2018), \u0431\u0456\u0440\u0430\u049b \u043e\u043b\u0430\u0439 \u0435\u043c\u0435\u0441. \u0435\u043c\u0434\u0456\u043a. HGPS-\u0442\u0456 \u0436\u0430\u049b\u0441\u0430\u0440\u0442\u0443 \u043c\u04af\u043c\u043a\u0456\u043d\u0434\u0456\u0433\u0456 \u0431\u0430\u0440 \u0436\u0430\u04a3\u0430 \u049b\u043e\u0441\u044b\u043b\u044b\u0441\u0442\u0430\u0440 \u0430\u043d\u044b\u049b\u0442\u0430\u043b\u0493\u0430\u043d\u0434\u044b\u049b\u0442\u0430\u043d, \u0431\u0456\u0437 \u0431\u04b1\u043b \u049b\u043e\u0441\u044b\u043b\u044b\u0441\u0442\u0430\u0440\u0434\u044b \u043b\u043e\u043d\u0430\u0444\u0430\u0440\u043d\u0438\u0431\u043f\u0435\u043d in vitro \u0436\u04d9\u043d\u0435 \u0436\u0430\u043d\u0443\u0430\u0440\u043b\u0430\u0440 \u04af\u043b\u0433\u0456\u043b\u0435\u0440\u0456\u043d\u0434\u0435 \u0441\u044b\u043d\u0430\u0443 \u049b\u0430\u0436\u0435\u0442\u0442\u0456\u043b\u0456\u0433\u0456\u043d \u043a\u04af\u0442\u0435\u043c\u0456\u0437.<\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][et_pb_image src=\u201dhttps:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/Zoey-at-hospital-JAN-13-2014-1-261\u00d7300.jpg\u201d \u0442\u0443\u0440\u0430\u043b\u0430\u0443 =\u201dcenter\u201dalign_tablet=\u201dcenter\u201dalign_phone=\u201d\u201d align_last_edited=\u201don|desktop\u201d disabled_on=\u201d||on\u201d admin_label=\u201d\u0421\u0443\u0440\u0435\u0442 (\u0442\u0435\u043a \u043c\u043e\u0431\u0438\u043b\u044c\u0434\u0456)\u201d _builder_version=\u201d4.16\u2033 z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d][\/et_pb_p_b=d][\u201ddisabled=\u201d |\u04e9\u0448\u0456\u0440\u0443|\u049b\u043e\u0441\u0443\u00bb admin_label=\u201d\u041c\u04d9\u0442\u0456\u043d (\u0442\u0435\u043a \u04b1\u044f\u043b\u044b \u0442\u0435\u043b\u0435\u0444\u043e\u043d)\u201d _builder_version=\u201d4.18.1\u2033 header_4_line_height=\u201d1.2em\u201d header_4_font_size_tablet=\u201d\u201d header_4_font_size_phone=\u201d23px\u201d header_4_font_size_last=\u201d| z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n<p>PRF \u0444\u0430\u0440\u043d\u0435\u0437\u0438\u043b\u0442\u0440\u0430\u043d\u0441\u0444\u0435\u0440\u0430\u0437\u0430 \u0438\u043d\u0433\u0438\u0431\u0438\u0442\u043e\u0440\u044b \u043b\u043e\u043d\u0430\u0444\u0430\u0440\u043d\u0438\u0431\u0442\u0456 \u0437\u0435\u0440\u0442\u0442\u0435\u0443 \u049b\u0430\u0443\u044b\u043c\u0434\u0430\u0441\u0442\u044b\u0493\u044b\u043d\u0430 \u049b\u043e\u043b\u0436\u0435\u0442\u0456\u043c\u0434\u0456 \u0435\u0442\u0435\u0434\u0456. \u0411\u0456\u0437\u0434\u0456\u04a3 \u043c\u0430\u049b\u0441\u0430\u0442\u044b\u043c\u044b\u0437 - \u043b\u043e\u043d\u0430\u0444\u0430\u0440\u043d\u0438\u0431\u0442\u0456\u04a3 \u041f\u0440\u043e\u0433\u0435\u0440\u0438\u044f\u0493\u0430 \u04d9\u0441\u0435\u0440\u0456\u043d \u043e\u0434\u0430\u043d \u04d9\u0440\u0456 \u0437\u0435\u0440\u0442\u0442\u0435\u0443 \u04af\u0448\u0456\u043d \u043a\u043b\u0438\u043d\u0438\u043a\u0430\u0493\u0430 \u0434\u0435\u0439\u0456\u043d\u0433\u0456 \u0437\u0435\u0440\u0442\u0442\u0435\u0443\u043b\u0435\u0440\u0433\u0435 \u049b\u043e\u043b\u0434\u0430\u0443 \u043a\u04e9\u0440\u0441\u0435\u0442\u0443.<\/p>\n<p>\u041f\u0440\u043e\u0433\u0435\u0440\u0438\u044f\u0441\u044b \u0431\u0430\u0440 \u0431\u0430\u043b\u0430\u043b\u0430\u0440\u0434\u044b \u0435\u043c\u0434\u0435\u0443\u0434\u0456\u04a3 \u0436\u0430\u049b\u0441\u044b \u04d9\u0434\u0456\u0441\u0442\u0435\u0440\u0456\u043d \u0436\u04d9\u043d\u0435 \u0435\u043c\u0434\u0435\u0443 \u04d9\u0434\u0456\u0441\u0442\u0435\u0440\u0456\u043d \u0442\u0430\u0431\u0443 PRF-\u0442\u0456\u04a3 \u0442\u04b1\u0440\u0430\u049b\u0442\u044b \u043c\u0438\u0441\u0441\u0438\u044f\u0441\u044b. \u041b\u043e\u043d\u0430\u0444\u0430\u0440\u043d\u0438\u0431 \u043a\u043b\u0438\u043d\u0438\u043a\u0430\u043b\u044b\u049b \u0442\u04b1\u0440\u0493\u044b\u0434\u0430\u043d \u0430\u0443\u0440\u0443\u0434\u044b\u04a3 \u043a\u0435\u0439\u0431\u0456\u0440 \u0430\u0441\u043f\u0435\u043a\u0442\u0456\u043b\u0435\u0440\u0456\u043d\u0435 \u043f\u0430\u0439\u0434\u0430\u0441\u044b\u043d \u0442\u0438\u0433\u0456\u0437\u0435\u0442\u0456\u043d\u0456 \u043a\u04e9\u0440\u0441\u0435\u0442\u0456\u043b\u0434\u0456 (\u0413\u043e\u0440\u0434\u043e\u043d \u0436\u04d9\u043d\u0435 \u0431\u0430\u0441\u049b\u0430\u043b\u0430\u0440, PNAS, 2012), \u0441\u043e\u043d\u0434\u0430\u0439-\u0430\u049b \u0431\u043e\u043b\u0436\u0430\u043c\u0434\u044b \u04e9\u043c\u0456\u0440 \u0441\u04af\u0440\u0443 \u04b1\u0437\u0430\u049b\u0442\u044b\u0493\u044b\u043d\u044b\u04a3 \u0430\u0440\u0442\u0443\u044b\u043d\u0430 \u04d9\u0441\u0435\u0440 \u0435\u0442\u0435\u0434\u0456 (\u0413\u043e\u0440\u0434\u043e\u043d \u0436\u04d9\u043d\u0435 \u0431\u0430\u0441\u049b\u0430\u043b\u0430\u0440, \u0426\u0438\u0440\u043a\u0443\u043b\u044f\u0446\u0438\u044f, 2014) (Gordon \u0436\u04d9\u043d\u0435 \u0431\u0430\u0441\u049b\u0430\u043b\u0430\u0440, JAMA, 2018), \u0431\u0456\u0440\u0430\u049b \u043e\u043b \u0435\u043c\u0434\u0456\u043a \u0435\u043c\u0435\u0441. HGPS-\u0442\u0456 \u0436\u0430\u049b\u0441\u0430\u0440\u0442\u0443 \u043c\u04af\u043c\u043a\u0456\u043d\u0434\u0456\u0433\u0456 \u0431\u0430\u0440 \u0436\u0430\u04a3\u0430 \u049b\u043e\u0441\u044b\u043b\u044b\u0441\u0442\u0430\u0440 \u0430\u043d\u044b\u049b\u0442\u0430\u043b\u0493\u0430\u043d\u0434\u044b\u049b\u0442\u0430\u043d, \u0431\u0456\u0437 \u0431\u04b1\u043b \u049b\u043e\u0441\u044b\u043b\u044b\u0441\u0442\u0430\u0440\u0434\u044b \u043b\u043e\u043d\u0430\u0444\u0430\u0440\u043d\u0438\u0431\u043f\u0435\u043d in vitro \u0436\u04d9\u043d\u0435 \u0436\u0430\u043d\u0443\u0430\u0440\u043b\u0430\u0440 \u04af\u043b\u0433\u0456\u043b\u0435\u0440\u0456\u043d\u0434\u0435 \u0441\u044b\u043d\u0430\u0443 \u049b\u0430\u0436\u0435\u0442\u0442\u0456\u043b\u0456\u0433\u0456\u043d \u043a\u04af\u0442\u0435\u043c\u0456\u0437.<\/p>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner custom_padding_last_edited=\u201don|phone\u201d _builder_version=\u201d4.16\u2033 custom_padding=\u201d|35px|0|0px\u201d|false| custom_padding_tablet=\u201d|35px||35px||true\u201d custom_padding_phone=\u201d\u201d animation_direction=\u201dtop\u201d global_colors_info=\u201d{}\u201d][et_pb_column_inner saved_specialty_column_type=\u201d3_4\u2033 _builder_version=|\u201d custom.1padding=|\u201d4 global_colors_info=\u201d{}\u201d custom_padding__hover=\u201d|||\u201d][et_pb_text disabled_on=\u201don|on|\u201d admin_label=\u201d\u0422\u0435\u0445\u043d\u0438\u043a\u0430\u043b\u044b\u049b \u0435\u0441\u043a\u0435\u0440\u0442\u043f\u0435\u043b\u0435\u0440\u201d _builder_version=\u201d4.18.1\u2033 header_4_line_height=\u201d1.2em\u201d header_4_font_size_tablet=\u201d\u201d header_4_font_size_phone=\u201d23px\u201d header_4_font_size=\u201dlast_onedi\u201d z_index_tablet=\u201d500\u2033 box_shadow_horizontal_tablet=\u201d0px\u201d box_shadow_vertical_tablet=\u201d0px\u201d box_shadow_blur_tablet=\u201d40px\u201d box_shadow_spread_tablet=\u201d0px\u201d global_colors_info=\u201d{}\u201d]<\/p>\n<h4><strong>\u0422\u0435\u0445\u043d\u0438\u043a\u0430\u043b\u044b\u049b \u0435\u0441\u043a\u0435\u0440\u0442\u0443\u043b\u0435\u0440<\/strong><\/h4>\n<p>[\/et_pb_text][et_pb_button button_url=&#8221;https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/09\/Lonafarnib-solubility.pdf&#8221; button_text=&#8221;Solubility PDF&#8221; admin_label=&#8221;Solubility PDF Button&#8221; _builder_version=&#8221;4.16&#8243; background_layout=&#8221;dark&#8221; z_index_tablet=&#8221;500&#8243; button_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; button_text_shadow_vertical_length_tablet=&#8221;0px&#8221; button_text_shadow_blur_strength_tablet=&#8221;1px&#8221; box_shadow_horizontal_tablet=&#8221;0px&#8221; box_shadow_vertical_tablet=&#8221;0px&#8221; box_shadow_blur_tablet=&#8221;40px&#8221; box_shadow_spread_tablet=&#8221;0px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_button][et_pb_button button_url=&#8221;https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/09\/Lonafarnib-administration-to-mice.pdf&#8221; button_text=&#8221;Administration PDF&#8221; admin_label=&#8221;Admin pdf button&#8221; _builder_version=&#8221;4.16&#8243; background_layout=&#8221;dark&#8221; custom_margin=&#8221;20px|||&#8221; z_index_tablet=&#8221;500&#8243; button_text_shadow_horizontal_length_tablet=&#8221;0px&#8221; button_text_shadow_vertical_length_tablet=&#8221;0px&#8221; button_text_shadow_blur_strength_tablet=&#8221;1px&#8221; box_shadow_horizontal_tablet=&#8221;0px&#8221; box_shadow_vertical_tablet=&#8221;0px&#8221; box_shadow_blur_tablet=&#8221;40px&#8221; box_shadow_spread_tablet=&#8221;0px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_button][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner column_structure=&#8221;1_2,1_2&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; padding_left_right_link_1=&#8221;true&#8221; padding_left_right_link_2=&#8221;true&#8221; _builder_version=&#8221;4.16&#8243; custom_margin=&#8221;39px||&#8221; custom_padding=&#8221;0|35px|30px|0px|false|false&#8221; custom_padding_tablet=&#8221;0px|35px||35px&#8221; custom_padding_phone=&#8221;0px||0px&#8221; animation_direction=&#8221;right&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column_inner type=&#8221;1_2&#8243; saved_specialty_column_type=&#8221;3_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; custom_padding_tablet=&#8221;|0px||0px&#8221; custom_padding_phone=&#8221;||30px&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;Ordering Information&#8221; _builder_version=&#8221;4.27.5&#8243; header_4_line_height=&#8221;1.2em&#8221; hover_enabled=&#8221;0&#8243; header_4_font_size_tablet=&#8221;&#8221; header_4_font_size_phone=&#8221;23px&#8221; header_4_font_size_last_edited=&#8221;on|phone&#8221; z_index_tablet=&#8221;500&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<h4><b>\u0422\u0430\u043f\u0441\u044b\u0440\u044b\u0441 \u0431\u0435\u0440\u0443 \u0442\u0443\u0440\u0430\u043b\u044b \u0430\u049b\u043f\u0430\u0440\u0430\u0442<\/b><\/h4>\n<p>\u041c\u0430\u0442\u0435\u0440\u0438\u0430\u043b \u0442\u0435\u0433\u0456\u043d \u0436\u0435\u0442\u043a\u0456\u0437\u0456\u043b\u0435\u0434\u0456. \u0410\u043b\u0443\u0448\u044b \u0431\u0430\u0440\u043b\u044b\u049b \u0436\u0435\u0442\u043a\u0456\u0437\u0443 \u0430\u049b\u044b\u0441\u044b\u043d \u0442\u04e9\u043b\u0435\u0439\u0434\u0456. \u041b\u043e\u043d\u0430\u0444\u0430\u0440\u043d\u0438\u0431\u0442\u0456 \u0430\u043b\u0443 \u04af\u0448\u0456\u043d \u04e9\u0442\u0456\u043d\u0456\u0448 \u043f\u0435\u043d \u043c\u0430\u0442\u0435\u0440\u0438\u0430\u043b\u0434\u044b \u0431\u0435\u0440\u0443 \u0442\u0443\u0440\u0430\u043b\u044b \u043a\u0435\u043b\u0456\u0441\u0456\u043c\u0434\u0456 \u0442\u043e\u043b\u0442\u044b\u0440\u044b\u043f, \u043c\u044b\u043d\u0430 \u043c\u0435\u043a\u0435\u043d\u0436\u0430\u0439\u0493\u0430 \u0436\u0456\u0431\u0435\u0440\u0456\u04a3\u0456\u0437 <a href=\"mailto:wnorris@brownhealth.org\" title=\"mailto:wnorris@brownhealth.org\" data-outlook-id=\"6ae643af-3829-46f7-8b6a-2ef767034802\">wnorris@brownhealth.org<\/a><\/p>\n<p><a href=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2025\/02\/PRF-Lonafarnib-Application-and-Agreement-June-2024.pdf\" rel=\"attachment wp-att-11238\">\u04e8\u0442\u0456\u043d\u0456\u0448 \u0436\u04d9\u043d\u0435 \u043a\u0435\u043b\u0456\u0441\u0456\u043c<\/a><\/p>\n<p><a href=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2026\/03\/Lonafarnib-non-government-MTA-October-2024.pdf\" target=\"_blank\" rel=\"attachment noopener noreferrer wp-att-10291\">\u041c\u0435\u043c\u043b\u0435\u043a\u0435\u0442\u0442\u0456\u043a \u0435\u043c\u0435\u0441 \u043c\u0435\u043a\u0435\u043c\u0435\u043b\u0435\u0440\u0433\u0435 \u0430\u0440\u043d\u0430\u043b\u0493\u0430\u043d \u043c\u0430\u0442\u0435\u0440\u0438\u0430\u043b\u0434\u044b \u0442\u0430\u0441\u044b\u043c\u0430\u043b\u0434\u0430\u0443 \u043a\u0435\u043b\u0456\u0441\u0456\u043c\u0456**<\/a><\/p>\n<p><strong>**<\/strong>\u00a0PRF \u0441\u0430\u044f\u0441\u0430\u0442\u044b \u0431\u0430\u0440\u00a0<strong>\u0431\u0456\u0437\u0434\u0456\u04a3 MTA-\u0493\u0430 \u0435\u0448\u049b\u0430\u043d\u0434\u0430\u0439 \u04e9\u0437\u0433\u0435\u0440\u0456\u0441 \u0436\u043e\u049b<\/strong>.<\/p>\n<p>[\/et_pb_text][\/et_pb_column_inner][et_pb_column_inner type=\u201d1_2\u2033 saved_specialty_column_type=\u201d3_4\u2033 _builder_version=\u201d4,16\u2033 custom_padding=\u201d|20px|pxtpx_|0\u201d|20px|pxtpx_|20px|30px_padding\u201d custom_padding_phone=\u201d||30px\u201d custom_padding_last_edited=\u201don|desktop\u201d global_colors_info=\u201d{}\u201d custom_padding__hover=\u201d|||\u201d][et_pb_image src=\u201dhttps:\/\/www.progeriaresearch.org\/wp-content\/uploads\/20 \/04\/FTI-graph.jpg\u201d align=\u201dcenter\u201d align_tablet=\u201dcenter\u201d align_phone=\u201d\u201d align_last_edited=\u201don|desktop\u201d _builder_version=\u201d4.16\u2033 animation_style=\u201dslide\u201d animation_direction=\u201dright\u201d animation_intensity_slide=\u201d3\u201dTP3\u201dinfo=\u201dTP3\u201d251<br \/>\n[\/et_pb_image][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner custom_padding_last_edited=&#8221;on|phone&#8221; padding_left_right_link_1=&#8221;true&#8221; padding_left_right_link_2=&#8221;true&#8221; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;25px|35px|30px|0px|false|false&#8221; custom_padding_tablet=&#8221;0px|35px||35px&#8221; custom_padding_phone=&#8221;0px||0px&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;right&#8221; animation_intensity_slide=&#8221;25%&#8221; border_width_top=&#8221;10px&#8221; 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\u043a\u04e9\u0440\u0441\u0435\u0442\u0443 \u04af\u0448\u0456\u043d \u0431\u0430\u0439\u043b\u0430\u043d\u044b\u0441\u0442\u0430\u0440:<\/strong><\/h4>\n<p>\u0411\u0430\u0441 \u0437\u0435\u0440\u0442\u0442\u0435\u0443\u0448\u0456: \u041b\u0435\u0441\u043b\u0438 \u0411. \u0413\u043e\u0440\u0434\u043e\u043d, MD, PhD;\u00a0<a href=\"mailto:lgordon@progeriaresearch.org\">lgordon@progeriaresearch.org<\/a><\/p>\n<p>PRF Cell &amp; Tissue Bank: \u0412\u0435\u043d\u0434\u0438 \u041d\u043e\u0440\u0440\u0438\u0441; <a href=\"mailto:wnorris@brownhealth.org\" title=\"mailto:wnorris@brownhealth.org\" data-outlook-id=\"6ae643af-3829-46f7-8b6a-2ef767034802\">wnorris@brownhealth.org<\/a><\/p>\n<p>\u0410\u049a\u0428 \u0444\u0435\u0434\u0435\u0440\u0430\u043b\u0434\u044b\u049b \u04af\u043a\u0456\u043c\u0435\u0442\u0442\u0456\u043a \u0438\u043d\u0441\u0442\u0438\u0442\u0443\u0442\u0442\u0430\u0440\u044b \u043d\u0435\u043c\u0435\u0441\u0435 \u0441\u04b1\u0440\u0430\u049b\u0442\u0430\u0440 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padding_2_last_edited=\u201don|desktop\u201d module_class_1=\u201dsidebar-secondary-nav\u201d module_class=_\u201dhandprint=6\u201dg.\u2033ilder. background_image=\u201dhttps:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/blue-handprint-only.png\u201d parallax=\u201don\u201d parallax_method=\u201doff\u201d inner_width=\u201d100%\u201d inner_max_width=\u201d100% \u00bb custom_padding=\u201d0|0px|54px|0px|false|false\u201d z_index_tablet=\u201d500\u2033 border_width_top=\u201d10px\u201d [\u2026]<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"\t\t\t\t[vc_row][vc_column][vc_custom_heading text=\"Lonafarnib Pre-clinical Drug Supply Program\" font_container=\"tag:h1|text_align:center\" use_theme_fonts=\"yes\"][vc_column_text]<strong>July 2015: Lonafarnib Now Available for Research<img class=\"alignright\" src=\"https:\/\/www.progeriaresearch.org\/assets\/images\/medical_images\/Zoey-at-hospital-JAN-13-2014-(1).jpg\" width=\"200\" height=\"230\" \/><\/strong>\r\n\r\nPRF is making the farnesyltransferase inhibitor lonafarnib available to the research community. Our goal is to support preclinical studies to further investigate the effects of lonafarnib on Progeria.\r\n\r\nIt is PRF's steadfast mission to find better treatments and a cure for children with Progeria. Lonafarnib has been shown to benefit some aspects of the disease clinically, (Gordon et al, PNAS, 2012)\u00a0as well as influence increased estimated lifespan, (Gordon et al, Circulation, 2014)\u00a0but it is not curative. As new compounds are identified with the potential to ameliorate HGPS, we anticipate the need to test these compounds in combination with lonafarnib in vitro and in animal models.\r\n\r\n<strong>Many thanks to the pharmaceutical company Merck for making this program possible.<\/strong>\r\n\r\n<b>Ordering Information<\/b>\r\n\r\nThe material is supplied at no cost.\u00a0 Recipient pays for all shipping charges.\r\n\r\nTo receive lonafarnib, please fill out an application and material transfer agreement, and submit to <a href=\"mailto:joan_brazier@brown.edu\">joan_brazier@brown.edu<\/a>\r\n\r\n<a href=\"https:\/\/www.progeriaresearch.org\/assets\/files\/Application-and-Agreement-For-Non-government-Institutions-(1).doc\"><img src=\"https:\/\/www.progeriaresearch.org\/assets\/images\/iconPDF.gif\" width=\"34\" height=\"20\" \/><\/a><a href=\"https:\/\/www.progeriaresearch.org\/assets\/files\/pdf\/PRF-Lonafarnib-Application-and-Agreement-Oct.-2016.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Application and Agreement<\/a>\r\n\r\n<img src=\"https:\/\/www.progeriaresearch.org\/assets\/images\/iconPDF.gif\" width=\"34\" height=\"20\" \/><a href=\"https:\/\/www.progeriaresearch.org\/assets\/files\/pdf\/PRF-Lonafarnib-MTA-for-Non-Govt-Institutions-Oct.-2015.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Material Transfer Agreement for Non-government Institutions<\/a>**\r\n\r\n<strong>**<\/strong> PRF has a policy of <strong>no changes to our MTA<\/strong>.\r\n\r\n<strong><img class=\"alignleft\" src=\"https:\/\/www.progeriaresearch.org\/assets\/images\/medical_images\/FTI-graph.jpg\" width=\"362\" height=\"290\" \/><\/strong>\r\n\r\n<strong>Contacts for Questions and Assistance:<\/strong>\r\n\r\nPrincipal Investigator: Leslie B. Gordon, MD, PhD; <a href=\"mailto:lgordon@progeriaresearch.org\">lgordon@progeriaresearch.org<\/a>\r\n\r\nResearch Study Coordinator: Joan Brazier; <a href=\"mailto:joan_brazier@brown.edu\">joan_brazier@brown.edu<\/a>\r\n\r\nFor U.S. Federal Government Institutions or questions, please contact Joan Brazier, Research Study Coordinator, at <a href=\"mailto:joan_brazier@brown.edu\">joan_brazier@brown.edu<\/a> or 401-863-9628.[\/vc_column_text][\/vc_column][\/vc_row]\t\t","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-790","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Lonafarnib drug supply | The Progeria Research Foundation<\/title>\n<meta name=\"description\" content=\"PRF is making the farnesyltransferase inhibitor lonafarnib available to the research community. 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