{"id":796,"date":"2017-02-26T19:20:42","date_gmt":"2017-02-26T19:20:42","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?page_id=796"},"modified":"2022-10-05T15:58:34","modified_gmt":"2022-10-05T19:58:34","slug":"the-fti-drug","status":"publish","type":"page","link":"https:\/\/www.progeriaresearch.org\/kk\/the-fti-drug\/","title":{"rendered":"FTI \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u044b"},"content":{"rendered":"

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FTI \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u044b<\/h1>\n

[\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=\u201d1\u2033 use_custom_gutter=\u201don\u201d gutter_width=\u201d1\u2033 specialty=\u201don\u201d padding_left_1=\u201d35px\u201d padding_left_2=\u201d35px\u201d padding_left_2=\u201dpxding_\u201d0\u201d|\u201d| padding_2_phone=\u201d|||0px\u201d padding_2_last_edited=\u201d|\u0436\u04b1\u043c\u044b\u0441 \u04af\u0441\u0442\u0435\u043b\u0456\u043d\u0434\u0435\u201d module_class_1=\u201dsidebar-secondary-nav\u201d module_class=\u201dhandprint-bg\u201d _builder_version=\u201d4.16\u2033 background_image=\u201dhttps:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/blue-handprint-only.png\u201d parallax=\u201don\u201d parallax_method=\u201doff\u201d inner_width=\u201d100%\u201d inner_max_width=\u201d100% \u00bb custom_padding=\u201d0|0px|54px|0px|false|false\u201d z_index_tablet=\u201d500\u2033 border_width_top=\u201d10px\u201d border_color_top=\u201d#8fd2ed\u201d use_custom_width=\u201don\u201d width_unit=\u201doff\u201d custom_width_percent=\u201dTP10 global_colors_info=\u201d{}\u201d][et_pb_column type=\u201d1_4\u2033 _builder_version=\u201d4.16\u2033 custom_padding=\u201d|||\u201d global_colors_info=\u201d{}\u201d custom_padding__hover=\u201d|||\u201d][et_pb_sidebar area=\u201det_pb_widget_area_18\u2033 disabled_on=\u201don|on|off\u201d module_class=\u201dsubpage-sidebars\u201d _builder_version=\u201d4.16\u2033style=\u201dfacebar z_index_tablet=\u201d500\u2033 border_width_right=\u201d5px\u201d global_colors_info=\u201d{}\u201d]
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\u0424\u0430\u0440\u043d\u0435\u0437\u0438\u043b\u0442\u0440\u0430\u043d\u0441\u0444\u0435\u0440\u0430\u0437\u0430 \u0438\u043d\u0433\u0438\u0431\u0438\u0442\u043e\u0440\u044b (FTI) \u043b\u043e\u043d\u0430\u0444\u0430\u0440\u043d\u0438\u0431 (\u0431\u0440\u0435\u043d\u0434 Zokinvy) \u041f\u0440\u043e\u0433\u0435\u0440\u0438\u044f\u0441\u044b \u0431\u0430\u0440 \u0431\u0430\u043b\u0430\u043b\u0430\u0440\u0493\u0430 \u0430\u0440\u043d\u0430\u043b\u0493\u0430\u043d \u0430\u043b\u0493\u0430\u0448\u049b\u044b \u0436\u04d9\u043d\u0435 \u0436\u0430\u043b\u0493\u044b\u0437 \u0431\u0435\u043b\u0433\u0456\u043b\u0456 \u0434\u04d9\u0440\u0456\u043b\u0456\u043a \u0435\u043c \u0431\u043e\u043b\u044b\u043f \u0442\u0430\u0431\u044b\u043b\u0430\u0434\u044b.<\/p>\n

\u0411\u04b1\u043b \u0442\u0430\u0440\u0438\u0445\u0438 \u0436\u0430\u04a3\u0430\u043b\u044b\u049b\u0442\u044b\u04a3 \u0442\u0430\u0440\u0438\u0445\u044b: 2005 \u0436\u044b\u043b\u0434\u044b\u04a3 \u0442\u0430\u043c\u044b\u0437\u044b\u043d\u0434\u0430 \u0436\u04d9\u043d\u0435 2006 \u0436\u044b\u043b\u0434\u044b\u04a3 \u0430\u049b\u043f\u0430\u043d\u044b\u043d\u0434\u0430 \u0437\u0435\u0440\u0442\u0442\u0435\u0443\u0448\u0456\u043b\u0435\u0440 \u041f\u0440\u043e\u0433\u0435\u0440\u0438\u044f\u0441\u044b \u0431\u0430\u0440 \u0431\u0430\u043b\u0430\u043b\u0430\u0440 \u04af\u0448\u0456\u043d \u044b\u049b\u0442\u0438\u043c\u0430\u043b \u0434\u04d9\u0440\u0456\u043b\u0456\u043a \u0435\u043c\u0434\u0456 \u049b\u043e\u043b\u0434\u0430\u0439\u0442\u044b\u043d \u0437\u0435\u0440\u0442\u0442\u0435\u0443\u043b\u0435\u0440\u0434\u0456 \u0436\u0430\u0440\u0438\u044f\u043b\u0430\u0434\u044b. \u0411\u0430\u0441\u0442\u0430\u043f\u049b\u044b\u0434\u0430 \u049b\u0430\u0442\u0435\u0440\u043b\u0456 \u0456\u0441\u0456\u043a \u0430\u0443\u0440\u0443\u044b\u043d \u0435\u043c\u0434\u0435\u0443 \u04af\u0448\u0456\u043d \u04d9\u0437\u0456\u0440\u043b\u0435\u043d\u0433\u0435\u043d \u043b\u043e\u043d\u0430\u0444\u0430\u0440\u043d\u0438\u0431 \u041f\u0440\u043e\u0433\u0435\u0440\u0438\u044f\u0441\u044b \u0431\u0430\u0440 \u0431\u0430\u043b\u0430\u043b\u0430\u0440 \u0436\u0430\u0441\u0443\u0448\u0430\u043b\u0430\u0440\u044b\u043d\u044b\u04a3 \u0435\u0440\u0435\u043a\u0448\u0435 \u0431\u0435\u043b\u0433\u0456\u0441\u0456 \u0431\u043e\u043b\u044b\u043f \u0442\u0430\u0431\u044b\u043b\u0430\u0442\u044b\u043d \u044f\u0434\u0440\u043e\u043b\u044b\u049b \u049b\u04b1\u0440\u044b\u043b\u044b\u043c\u043d\u044b\u04a3 \u043a\u04af\u0440\u0442 \u0430\u0443\u044b\u0442\u049b\u0443\u043b\u0430\u0440\u044b\u043d \u0436\u043e\u0439\u0434\u044b. \u0421\u043e\u043d\u044b\u043c\u0435\u043d \u049b\u0430\u0442\u0430\u0440, \u0431\u04b1\u043b FTI \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u044b \u041f\u0440\u043e\u0433\u0435\u0440\u0438\u044f \u0442\u04d9\u0440\u0456\u0437\u0434\u0456 \u0442\u0456\u043d\u0442\u0443\u0456\u0440 \u04af\u043b\u0433\u0456\u0441\u0456\u043d\u0434\u0435\u0433\u0456 \u0430\u0443\u0440\u0443\u0434\u044b\u04a3 \u043a\u0435\u0439\u0431\u0456\u0440 \u0431\u0435\u043b\u0433\u0456\u043b\u0435\u0440\u0456\u043d \u0436\u0430\u049b\u0441\u0430\u0440\u0442\u0442\u044b.<\/p>\n

\u041d\u0435\u043b\u0456\u043a\u0442\u0435\u043d \u0437\u0435\u0440\u0442\u0442\u0435\u0443\u0448\u0456\u043b\u0435\u0440 \u0431\u04b1\u043b \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442 \u041f\u0440\u043e\u0433\u0435\u0440\u0438\u044f\u0434\u0430 \u0436\u04b1\u043c\u044b\u0441 \u0456\u0441\u0442\u0435\u0439\u0434\u0456 \u0434\u0435\u043f \u043e\u0439\u043b\u0430\u0434\u044b? \u041f\u0440\u043e\u0433\u0435\u0440\u0438\u044f\u0493\u0430 \u0436\u0430\u0443\u0430\u043f \u0431\u0435\u0440\u0435\u0442\u0456\u043d \u0430\u049b\u0443\u044b\u0437 \u043f\u0440\u043e\u0433\u0435\u0440\u0438\u043d \u0434\u0435\u043f \u0430\u0442\u0430\u043b\u0430\u0434\u044b. \u0416\u0430\u0441\u0443\u0448\u0430\u043d\u044b\u04a3 \u049b\u0430\u043b\u044b\u043f\u0442\u044b \u0436\u04b1\u043c\u044b\u0441\u044b\u043d \u0431\u043b\u043e\u043a\u0442\u0430\u0443 \u0436\u04d9\u043d\u0435 \u041f\u0440\u043e\u0433\u0435\u0440\u0438\u044f\u043d\u044b \u0442\u0443\u0434\u044b\u0440\u0443 \u04af\u0448\u0456\u043d \u043f\u0440\u043e\u0433\u0435\u0440\u0438\u043d \u0430\u049b\u0443\u044b\u0437\u044b\u043d\u0430 \u00ab\u0444\u0430\u0440\u043d\u0435\u0437\u0438\u043b \u0442\u043e\u0431\u044b\u00bb \u0434\u0435\u043f \u0430\u0442\u0430\u043b\u0430\u0442\u044b\u043d \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u0430 \u049b\u043e\u0441\u044b\u043b\u0443\u044b \u043a\u0435\u0440\u0435\u043a. FTIs \u0444\u0430\u0440\u043d\u0435\u0437\u0438\u043b \u0442\u043e\u0431\u044b\u043d\u044b\u04a3 \u043f\u0440\u043e\u0433\u0435\u0440\u0438\u043d\u0433\u0435 \u049b\u043e\u0441\u044b\u043b\u0443\u044b\u043d \u0442\u0435\u0436\u0435\u0443 (\u0438\u043d\u0433\u0438\u0431\u0438\u0446\u0438\u044f\u043b\u0430\u0443) \u0430\u0440\u049b\u044b\u043b\u044b \u04d9\u0440\u0435\u043a\u0435\u0442 \u0435\u0442\u0435\u0434\u0456. \u0421\u043e\u043d\u044b\u043c\u0435\u043d, \u0435\u0433\u0435\u0440 FTI \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u044b \u041f\u0440\u043e\u0433\u0435\u0440\u0438\u044f\u0441\u044b \u0431\u0430\u0440 \u0431\u0430\u043b\u0430\u043b\u0430\u0440\u0434\u0430 \u0444\u0430\u0440\u043d\u0435\u0437\u0438\u043b \u0442\u043e\u0431\u044b\u043d\u044b\u04a3 \u049b\u043e\u0441\u044b\u043b\u0443\u044b\u043d \u0431\u04e9\u0433\u0435\u0441\u0435, \u043e\u043d\u0434\u0430 \u043f\u0440\u043e\u0433\u0435\u0440\u0438\u043d \u00ab\u0441\u0430\u043b\u0434\u0430\u043d\u0443\u044b\u00bb \u0436\u04d9\u043d\u0435 \u041f\u0440\u043e\u0433\u0435\u0440\u0438\u044f\u043d\u044b\u04a3 \u0436\u0430\u049b\u0441\u0430\u0440\u0443\u044b \u043c\u04af\u043c\u043a\u0456\u043d.<\/p>\n

\u0410\u043b\u0493\u0430\u0448 \u0440\u0435\u0442 \u0431\u0456\u0437\u0434\u0456\u04a3 \u0430\u043b\u0434\u044b\u043c\u044b\u0437\u0434\u0430 \u041f\u0440\u043e\u0433\u0435\u0440\u0438\u044f \u0430\u0443\u0440\u0443\u044b\u043d\u0430 \u0448\u0430\u043b\u0434\u044b\u049b\u049b\u0430\u043d \u0431\u0430\u043b\u0430\u043b\u0430\u0440\u0493\u0430 \u0430\u0440\u043d\u0430\u043b\u0493\u0430\u043d \u044b\u049b\u0442\u0438\u043c\u0430\u043b \u0435\u043c \u0431\u043e\u043b\u0434\u044b. \u0410 Progeria \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u044b\u043d\u044b\u04a3 \u0430\u043b\u0493\u0430\u0448\u049b\u044b \u043a\u043b\u0438\u043d\u0438\u043a\u0430\u043b\u044b\u049b \u0441\u044b\u043d\u0430\u0493\u044b<\/a> 2007 \u0436\u044b\u043b\u044b \u0431\u0430\u0441\u0442\u0430\u043b\u0434\u044b, \u0430\u043b 2012 \u0436\u044b\u043b\u044b \u0437\u0435\u0440\u0442\u0442\u0435\u0443 \u043d\u04d9\u0442\u0438\u0436\u0435\u043b\u0435\u0440\u0456 \u0436\u0430\u0440\u0438\u044f\u043b\u0430\u043d\u0434\u044b, \u0431\u04b1\u043b \u04d9\u0440\u0431\u0456\u0440 \u0431\u0430\u043b\u0430\u043d\u044b\u04a3 \u0431\u0456\u0440 \u043d\u0435\u043c\u0435\u0441\u0435 \u0431\u0456\u0440\u043d\u0435\u0448\u0435 \u0441\u0430\u043b\u0430\u043b\u0430\u0440\u0434\u0430, \u0441\u043e\u043d\u044b\u04a3 \u0456\u0448\u0456\u043d\u0434\u0435 \u04e9\u043c\u0456\u0440\u043b\u0456\u043a \u043c\u0430\u04a3\u044b\u0437\u0434\u044b \u0436\u04af\u0440\u0435\u043a-\u0442\u0430\u043c\u044b\u0440 \u0436\u04af\u0439\u0435\u0441\u0456\u043d\u0434\u0435 \u0436\u0430\u049b\u0441\u0430\u0440\u0493\u0430\u043d\u044b\u043d \u043a\u04e9\u0440\u0441\u0435\u0442\u0442\u0456. 2014 \u0436\u044b\u043b\u0434\u044b\u04a3 \u043c\u0430\u043c\u044b\u0440\u044b\u043d\u0434\u0430 \u04d9\u0440\u0456 \u049b\u0430\u0440\u0430\u0439 \u0437\u0435\u0440\u0442\u0442\u0435\u0443 \u043b\u043e\u043d\u0430\u0444\u0430\u0440\u043d\u0438\u0431\u0442\u0456\u04a3 \u0431\u043e\u043b\u0436\u0430\u043c\u0434\u044b \u04e9\u043c\u0456\u0440 \u0441\u04af\u0440\u0443 \u04b1\u0437\u0430\u049b\u0442\u044b\u0493\u044b\u043d \u043a\u0435\u043c \u0434\u0435\u0433\u0435\u043d\u0434\u0435 1,6 \u0436\u044b\u043b\u0493\u0430 \u04b1\u0437\u0430\u0440\u0442\u0430\u0434\u044b (\u0437\u0435\u0440\u0442\u0442\u0435\u0443 \u043e\u0434\u0430\u043d \u04d9\u0440\u0456 \u0456\u043b\u0433\u0435\u0440\u0456\u043b\u0435\u0433\u0435\u043d \u0441\u0430\u0439\u044b\u043d \u0431\u04b1\u043b \u043a\u0435\u0439\u0456\u043d\u0456\u0440\u0435\u043a \u04b1\u043b\u0493\u0430\u044f\u0434\u044b) \u0436\u04d9\u043d\u0435 2018 \u0436\u044b\u043b\u0434\u044b\u04a3 \u0441\u04d9\u0443\u0456\u0440\u0456\u043d\u0434\u0435 \u0436\u0430\u0440\u0438\u044f\u043b\u0430\u043d\u0493\u0430\u043d \u0437\u0435\u0440\u0442\u0442\u0435\u0443 \u0410\u043c\u0435\u0440\u0438\u043a\u0430\u043d\u0434\u044b\u049b \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0430 \u049b\u0430\u0443\u044b\u043c\u0434\u0430\u0441\u0442\u044b\u0493\u044b\u043d\u044b\u04a3 \u0436\u0443\u0440\u043d\u0430\u043b\u044b (JAMA)<\/em> \u041b\u043e\u043d\u0430\u0444\u0430\u0440\u043d\u0438\u0431\u0442\u0456\u04a3 \u04e9\u0437\u0456 \u041f\u0440\u043e\u0433\u0435\u0440\u0438\u044f\u0441\u044b \u0431\u0430\u0440 \u0431\u0430\u043b\u0430\u043b\u0430\u0440\u0434\u0430 \u04e9\u043c\u0456\u0440 \u0441\u04af\u0440\u0443\u0434\u0456 \u04b1\u0437\u0430\u0440\u0442\u049b\u0430\u043d\u044b\u043d \u0445\u0430\u0431\u0430\u0440\u043b\u0430\u0434\u044b. \u00a0\u041c\u044b\u043d\u0434\u0430 \u0431\u0430\u0441\u044b\u04a3\u044b\u0437<\/a> 2012 \u0436\u044b\u043b\u0493\u044b \u0437\u0435\u0440\u0442\u0442\u0435\u0443 \u0442\u0443\u0440\u0430\u043b\u044b \u0442\u043e\u043b\u044b\u049b \u0430\u049b\u043f\u0430\u0440\u0430\u0442 \u0430\u043b\u0443 \u04af\u0448\u0456\u043d,\u00a0\u041c\u04b1\u043d\u0434\u0430 <\/a>2014 \u0436\u044b\u043b\u0493\u044b \u049b\u043e\u0440\u044b\u0442\u044b\u043d\u0434\u044b\u043b\u0430\u0440 \u0442\u0443\u0440\u0430\u043b\u044b \u0442\u043e\u043b\u044b\u049b \u0430\u049b\u043f\u0430\u0440\u0430\u0442 \u0430\u043b\u0443 \u04af\u0448\u0456\u043d \u0436\u04d9\u043d\u0435 \u041c\u04b1\u043d\u0434\u0430<\/a> 2018 \u0436\u044b\u043b\u0493\u044b \u0437\u0435\u0440\u0442\u0442\u0435\u0443 \u0442\u0443\u0440\u0430\u043b\u044b \u0442\u043e\u043b\u044b\u049b \u0430\u049b\u043f\u0430\u0440\u0430\u0442 \u0430\u043b\u0443 \u04af\u0448\u0456\u043d.<\/p>\n

2018 \u0436\u044b\u043b\u0434\u044b\u04a3 \u043c\u0430\u043c\u044b\u0440 \u0430\u0439\u044b\u043d\u0434\u0430 \u0436\u0430\u0440\u0438\u044f\u043b\u0430\u043d\u0493\u0430\u043d \u0437\u0435\u0440\u0442\u0442\u0435\u0443 \u04e9\u043a\u0448\u0435\u0441\u0456\u043d\u0434\u0435 \u0416\u0410\u041c\u0410<\/em>, PRF \u0436\u04d9\u043d\u0435 Eiger Biopharmaceuticals \u0410\u049a\u0428-\u0442\u044b\u04a3 \u0410\u0437\u044b\u049b-\u0442\u04af\u043b\u0456\u043a \u0436\u04d9\u043d\u0435 \u0434\u04d9\u0440\u0456-\u0434\u04d9\u0440\u043c\u0435\u043a \u0431\u0430\u0441\u049b\u0430\u0440\u043c\u0430\u0441\u044b \u0448\u043e\u043b\u0443\u044b\u043d \u04d9\u0437\u0456\u0440\u043b\u0435\u0443 \u0436\u04d9\u043d\u0435 \u0456\u0437\u0434\u0435\u0441\u0442\u0456\u0440\u0443 \u0436\u04d9\u043d\u0435 \u0431\u0430\u043b\u0430\u043b\u0430\u0440\u0434\u0430\u0493\u044b \u041f\u0440\u043e\u0433\u0435\u0440\u0438\u044f\u043d\u044b \u0435\u043c\u0434\u0435\u0443\u0433\u0435 \u0430\u0440\u043d\u0430\u043b\u0493\u0430\u043d \u043b\u043e\u043d\u0430\u0444\u0430\u0440\u043d\u0438\u0431\u0442\u0456 \u044b\u049b\u0442\u0438\u043c\u0430\u043b \u043c\u0430\u049b\u04b1\u043b\u0434\u0430\u0443 \u04af\u0448\u0456\u043d \u044b\u043d\u0442\u044b\u043c\u0430\u049b\u0442\u0430\u0441\u0442\u044b\u049b \u0436\u04d9\u043d\u0435 \u0436\u0435\u0442\u043a\u0456\u0437\u0443 \u0442\u0443\u0440\u0430\u043b\u044b \u043a\u0435\u043b\u0456\u0441\u0456\u043c\u0433\u0435 \u043e\u0442\u044b\u0440\u0434\u044b. \u04e8\u0442\u0456\u043d\u0456\u0448 2020 \u0436\u044b\u043b\u0434\u044b\u04a3 23 \u043d\u0430\u0443\u0440\u044b\u0437\u044b\u043d\u0434\u0430 \u0430\u044f\u049b\u0442\u0430\u043b\u0434\u044b. <\/a>2020 \u0436\u044b\u043b\u0434\u044b\u04a3 \u049b\u0430\u0440\u0430\u0448\u0430 \u0430\u0439\u044b\u043d\u0434\u0430 \u043b\u043e\u043d\u0430\u0444\u0430\u0440\u043d\u0438\u0431 \u0442\u0430\u0440\u0438\u0445\u049b\u0430 \u0435\u043d\u0434\u0456 \u0410\u049a\u0428-\u0442\u044b\u04a3 \u0410\u0437\u044b\u049b-\u0442\u04af\u043b\u0456\u043a \u0436\u04d9\u043d\u0435 \u0434\u04d9\u0440\u0456-\u0434\u04d9\u0440\u043c\u0435\u043a \u0431\u0430\u0441\u049b\u0430\u0440\u043c\u0430\u0441\u044b (FDA) \u0440\u04b1\u049b\u0441\u0430\u0442\u044b\u043d \u0430\u043b\u0493\u0430\u043d \u0442\u04b1\u04a3\u0493\u044b\u0448 \u0435\u043c\u0434\u0435\u0443<\/a> \u041f\u0440\u043e\u0433\u0435\u0440\u0438\u044f \u0436\u04d9\u043d\u0435 \u043f\u0440\u043e\u0433\u0435\u0440\u043e\u0438\u0434\u0442\u044b \u043b\u0430\u043c\u0438\u043d\u043e\u043f\u0430\u0442\u0438\u044f\u043b\u0430\u0440 \u04af\u0448\u0456\u043d.<\/p>\n

\u049a\u0430\u0437\u0456\u0440 \u0431\u0456\u0437\u0434\u0435 \u041f\u0440\u043e\u0433\u0435\u0440\u0438\u044f\u043d\u044b \u0435\u043c\u0434\u0435\u0443\u0434\u0456\u04a3 \u0431\u0456\u0440 \u0442\u04af\u0440\u0456 \u0431\u0430\u0440, \u0431\u0456\u0440\u0430\u049b \u043e\u043b \u0435\u043c \u0435\u043c\u0435\u0441, \u0441\u043e\u043d\u0434\u044b\u049b\u0442\u0430\u043d \u0431\u0456\u0437 \u043e\u0434\u0430\u043d \u0434\u0430 \u0442\u0438\u0456\u043c\u0434\u0456\u0440\u0435\u043a \u0436\u04d9\u043d\u0435 \u0430\u049b\u044b\u0440\u044b\u043d\u0434\u0430 \u041f\u0440\u043e\u0433\u0435\u0440\u0438\u044f\u043d\u044b \u0435\u043c\u0434\u0435\u0439\u0442\u0456\u043d \u0434\u04d9\u0440\u0456\u043b\u0435\u0440\u0434\u0456 \u0442\u0430\u0431\u0443 \u04af\u0448\u0456\u043d \u0437\u0435\u0440\u0442\u0442\u0435\u0443\u0434\u0456 \u0436\u0430\u043b\u0493\u0430\u0441\u0442\u044b\u0440\u0430\u043c\u044b\u0437.<\/p>\n

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\u0422\u0456\u0440\u043a\u0435\u043b\u0443<\/h2>\n

\u0411\u0456\u0437\u0434\u0456\u04a3 \u04af\u0448\u0456\u043d<\/h2>\n

\u0410\u049b\u043f\u0430\u0440\u0430\u0442\u0442\u044b\u049b \u0431\u044e\u043b\u043b\u0435\u0442\u0435\u043d\u044c!<\/h2>\n

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\u0411\u0456\u0440\u0433\u0435, \u0431\u0456\u0437<\/h2>\n

\u0411\u041e\u041b\u0410\u0414\u042b<\/em><\/h2>\n

\u0435\u043c\u0456\u043d \u0442\u0430\u043f!<\/h2>\n

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[et_pb_section fb_built=\u201d1\u2033 fullwidth=\u201don\u201d disabled_on=\u201doff|off|off\u201d _builder_version=\u201d4.16\u2033 border_width_bottom=\u201d55px\u201d border_color_bottom=\u201d#29327a\u201d global_colors_info=\u201d{p}b _builder_version=\u201d4.16\u2033 title_font_size=\u201d55\u2033 background_color=\u201d#29327a\u201d background_image=\u201dhttps:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/About-Header_position\u201d background_position\u201djp custom_padding=\u201d9vw||9vw||true\u201d custom_padding_tablet=\u201d\u201d custom_padding_phone=\u201d|56px||\u201d custom_padding_last_edited=\u201don|desktop\u201d title_font_size_tablet=\u201d45px\u201d title_font_size_phone=\u201d40px\u201d title_font_size_last_edited=\u201don|phone\u201d z_index_tablet=\u201d500\u2033 custom_css_main_round=\u201dTPCenter=\u201dbackg18- !\u043c\u0430\u04a3\u044b\u0437\u0434\u044b;\u201d global_colors_info=\u201d{}\u201d] FTI \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u044b [\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=\u201d1\u2033 use_custom_gutter=\u201don\u201d gutter_width=\u201d1\u2033 specialty=\u201don\u201d padding_leftpx_1\u201dpx_5=\u201dpadding\u201d3\u201d padding_2_tablet=\u201d|||0px\u201d padding_2_phone=\u201d|||0px\u201d padding_2_last_edited=\u201don|desktop\u201d module_class_1=\u201dsidebar-secondary-nav\u201d module_class=\u201dhandprint-bg\u201d _builder_version=6\u20331. background_image=\u201dhttps:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/blue-handprint-only.png\u201d parallax=\u201don\u201d parallax_method=\u201doff\u201d inner_width=\u201d100%\u201d inner_max_width=\u201d100% custom_padding=\u201d0|0px|54px|0px|false|false\u201d z_index_tablet=\u201d500\u2033 border_width_top=\u201d10px\u201d border_color_top=\u201d#8fd2ed\u201d use_custom_width=\u201don\u201d width_unit=\u201doff\u201d custom_width_percent=\u201dTP10 global_colors_info=\u201d{}\u201d][et_pb_column [\u2026]<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"\t\t\t\t[vc_row][vc_column][vc_custom_heading text=\"The FTI Drug Lonafarnib\" font_container=\"tag:h1|text_align:center\" use_theme_fonts=\"yes\"][vc_custom_heading text=\"The FTI lonafarnib \u2013 the first and only known drug treatment for children with Progeria\" use_theme_fonts=\"yes\"][vc_column_text]In August 2005 and February 2006, researchers published studies that supported a potential drug treatment for children with Progeria. Farnesyltransferase inhibitors (FTIs)<\/b>, originally developed to potentially treat cancer, reversed the dramatic nuclear structure abnormalities that are the hallmark of cells from children with Progeria. In addition, this FTI drug improves some signs of disease in a Progeria-like mouse model.\r\n\r\nWhy did researchers think this drug would work in Progeria?<\/b> The protein that we believe is responsible for Progeria is called progerin.\u00a0In order to block normal cell function and cause Progeria, a molecule called a \u201cfarnesyl group\u201d must be attached to the progerin protein. FTIs act by blocking (inhibiting) the attachment of the farnesyl group onto progerin. \u00a0So if the FTI drug can block this farnesyl group attachment in children with Progeria, then progerin may be \u201cparalyzed\u201d and Progeria improved.\r\n\r\nFor the first time, we had in front of us a possible treatment for children with Progeria.\u00a0<\/b>A first-ever clinical drug trial<\/b><\/a>\u00a0began in 2007, and in 2012 <\/b>the study results were published, demonstrating that every child experienced improvement in one or more areas, including the vital cardiovascular system.\u00a0 In May 2014, further study revealed lonafarnib increases estimated lifespan by at least 1.6 years (time will tell if that number increases \u2013 it just hasn\u2019t been long enough to determine)\u00a0and in April 2018 a study published in The Journal of the American Medical Association (JAMA)<\/em> reported that lonafarnib alone extended survival in children with Progeria. \u00a0Click here<\/b><\/a> for details on the 2012 study,\u00a0here<\/b> <\/a>for details on the 2014 findings, and here<\/a><\/strong> for details on the 2018 study.\r\n\r\nIn May 2018, on the heels of the study published in JAMA<\/em>, PRF and Eiger Biopharmaceuticals entered into collaboration and supply agreement for the development and pursuit of U.S. Food and Drug Administration review and potential approval of lonafarnib for the treatment of Progeria in children. Lonafarnib will mark the first therapy submitted to the FDA for the treatment of Progeria.\r\n\r\nWe now have one treatment for Progeria but it is not a cure, so we continue to drive the research to discover drugs that will be even more effective, and ultimately cure Progeria.[\/vc_column_text][\/vc_column][\/vc_row]\t\t","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-796","page","type-page","status-publish","hentry"],"yoast_head":"\nThe FTI Drug | The Progeria Research Foundation<\/title>\n<meta name=\"description\" content=\"Farnesyltransferase inhibitors (FTIs) is the first and only known drug treatment for children with Progeria.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.progeriaresearch.org\/kk\/the-fti-drug\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" 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