{"id":12401,"date":"2021-03-11T21:08:40","date_gmt":"2021-03-12T02:08:40","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?p=12401"},"modified":"2022-11-14T17:12:14","modified_gmt":"2022-11-14T22:12:14","slug":"exciting-breakthroughs-in-rna-therapeutics-for-progeria","status":"publish","type":"post","link":"https:\/\/www.progeriaresearch.org\/kn\/2021\/03\/11\/exciting-breakthroughs-in-rna-therapeutics-for-progeria\/","title":{"rendered":"\u0caa\u0ccd\u0cb0\u0cca\u0c9c\u0cc6\u0cb0\u0cbf\u0caf\u0cbe\u0c97\u0cbe\u0c97\u0cbf \u0c86\u0cb0\u0ccd\u0c8e\u0ca8\u0ccd\u0c8e \u0c9a\u0cbf\u0c95\u0cbf\u0ca4\u0ccd\u0cb8\u0c95\u0ca6\u0cb2\u0ccd\u0cb2\u0cbf \u0c85\u0ca4\u0ccd\u0caf\u0cbe\u0c95\u0cb0\u0ccd\u0cb7\u0c95 \u0caa\u0ccd\u0cb0\u0c97\u0ca4\u0cbf\u0c97\u0cb3\u0cc1!"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;section&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_row admin_label=&#8221;row&#8221; _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.18.1&#8243; _module_preset=&#8221;default&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-12360 alignnone size-full aligncenter\" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2021\/03\/Carlos.jpg\" alt=\"\" width=\"150\" height=\"300\" \/><\/p>\n<p>\u0cab\u0cb2\u0cbf\u0ca4\u0cbe\u0c82\u0cb6\u0c97\u0cb3\u0ca8\u0ccd\u0ca8\u0cc1 \u0cb9\u0c82\u0c9a\u0cbf\u0c95\u0cca\u0cb3\u0ccd\u0cb3\u0cb2\u0cc1 \u0ca8\u0cbe\u0cb5\u0cc1 \u0cb0\u0ccb\u0cae\u0cbe\u0c82\u0c9a\u0ca8\u0c97\u0cca\u0c82\u0ca1\u0cbf\u0ca6\u0ccd\u0ca6\u0cc7\u0cb5\u0cc6<strong> \u0c86\u0cb0\u0ccd\u200c\u0c8e\u0ca8\u0ccd\u200c\u0c8e \u0c9a\u0cbf\u0c95\u0cbf\u0ca4\u0ccd\u0cb8\u0c95\u0c97\u0cb3 \u0cac\u0cb3\u0c95\u0cc6\u0caf \u0cae\u0cc7\u0cb2\u0cc6 \u0c8e\u0cb0\u0ca1\u0cc1 \u0cb0\u0ccb\u0c9a\u0c95 \u0caa\u0ccd\u0cb0\u0c97\u0ca4\u0cbf\u0caf \u0c85\u0ca7\u0ccd\u0caf\u0caf\u0ca8\u0c97\u0cb3\u0cc1<\/strong> \u0caa\u0ccd\u0cb0\u0cca\u0c9c\u0cc6\u0cb0\u0cbf\u0caf\u0cbe \u0cb8\u0c82\u0cb6\u0ccb\u0ca7\u0ca8\u0cc6\u0caf\u0cb2\u0ccd\u0cb2\u0cbf. \u0c8e\u0cb0\u0ca1\u0cc2 \u0c85\u0ca7\u0ccd\u0caf\u0caf\u0ca8\u0c97\u0cb3\u0cc1 \u0caa\u0ccd\u0cb0\u0cca\u0c9c\u0cc6\u0cb0\u0cbf\u0caf\u0cbe \u0cb0\u0cbf\u0cb8\u0cb0\u0ccd\u0c9a\u0ccd \u0cab\u0ccc\u0c82\u0ca1\u0cc7\u0cb6\u0ca8\u0ccd (PRF) \u0ca8\u0cbf\u0c82\u0ca6 \u0cb8\u0cb9-\u0ca7\u0ca8\u0cb8\u0cb9\u0cbe\u0caf\u0cb5\u0ca8\u0ccd\u0ca8\u0cc1 \u0caa\u0ca1\u0cc6\u0ca6\u0cbf\u0cb5\u0cc6 \u0cae\u0ca4\u0ccd\u0ca4\u0cc1 PRF \u0ca8 \u0cb5\u0cc8\u0ca6\u0ccd\u0caf\u0c95\u0cc0\u0caf \u0ca8\u0cbf\u0cb0\u0ccd\u0ca6\u0cc7\u0cb6\u0c95 \u0ca1\u0cbe. \u0cb2\u0cc6\u0cb8\u0ccd\u0cb2\u0cbf \u0c97\u0cbe\u0cb0\u0ccd\u0ca1\u0ca8\u0ccd \u0cb8\u0cb9-\u0cb2\u0cc7\u0c96\u0c95\u0cb0\u0cbe\u0c97\u0cbf\u0ca6\u0ccd\u0ca6\u0cbe\u0cb0\u0cc6.<\/p>\n<p>\u0caa\u0ccd\u0cb0\u0cca\u0c9c\u0cc6\u0cb0\u0cbf\u0caf\u0cbe\u0ca6\u0cb2\u0ccd\u0cb2\u0cbf \u0caa\u0ccd\u0cb0\u0cca\u0c9c\u0cc6\u0cb0\u0cbf\u0ca8\u0ccd \u0cb0\u0ccb\u0c97\u0cb5\u0ca8\u0ccd\u0ca8\u0cc1 \u0c89\u0c82\u0c9f\u0cc1\u0cae\u0cbe\u0ca1\u0cc1\u0cb5 \u0caa\u0ccd\u0cb0\u0ccb\u0c9f\u0cc0\u0ca8\u0ccd \u0c86\u0c97\u0cbf\u0ca6\u0cc6. \u0c86\u0cb0\u0ccd\u200c\u0c8e\u0ca8\u0ccd\u200c\u0c8e \u0c9a\u0cbf\u0c95\u0cbf\u0ca4\u0ccd\u0cb8\u0cc6\u0c97\u0cb3\u0cc1 \u0c86\u0cb0\u0ccd\u200c\u0c8e\u0ca8\u0ccd\u200c\u0c8e \u0cae\u0c9f\u0ccd\u0c9f\u0ca6\u0cb2\u0ccd\u0cb2\u0cbf \u0c85\u0ca6\u0cb0 \u0c89\u0ca4\u0ccd\u0caa\u0cbe\u0ca6\u0ca8\u0cc6\u0caf\u0ca8\u0ccd\u0ca8\u0cc1 \u0ca4\u0ca1\u0cc6\u0caf\u0cc1\u0cb5 \u0cae\u0cc2\u0cb2\u0c95 \u0caa\u0ccd\u0cb0\u0cca\u0c9c\u0cc6\u0cb0\u0cbf\u0ca8\u0ccd \u0c89\u0ca4\u0ccd\u0caa\u0cbe\u0ca6\u0cbf\u0cb8\u0cc1\u0cb5 \u0ca6\u0cc7\u0cb9\u0ca6 \u0cb8\u0cbe\u0cae\u0cb0\u0ccd\u0ca5\u0ccd\u0caf\u0c95\u0ccd\u0c95\u0cc6 \u0c85\u0ca1\u0ccd\u0ca1\u0cbf\u0caa\u0ca1\u0cbf\u0cb8\u0cc1\u0ca4\u0ccd\u0ca4\u0cb5\u0cc6. \u0c87\u0ca6\u0cb0 \u0c85\u0cb0\u0ccd\u0ca5<strong> \u0c9a\u0cbf\u0c95\u0cbf\u0ca4\u0ccd\u0cb8\u0cc6\u0caf\u0cc1 \u0cb9\u0cc6\u0c9a\u0ccd\u0c9a\u0cbf\u0ca8 \u0c9a\u0cbf\u0c95\u0cbf\u0ca4\u0ccd\u0cb8\u0cc6\u0c97\u0cb3\u0cbf\u0c97\u0cbf\u0c82\u0ca4 \u0cb9\u0cc6\u0c9a\u0ccd\u0c9a\u0cc1 \u0ca8\u0cbf\u0cb0\u0ccd\u0ca6\u0cbf\u0cb7\u0ccd\u0c9f\u0cb5\u0cbe\u0c97\u0cbf\u0ca6\u0cc6<\/strong> \u0caa\u0ccd\u0cb0\u0ccb\u0c9f\u0cc0\u0ca8\u0ccd \u0cae\u0c9f\u0ccd\u0c9f\u0ca6\u0cb2\u0ccd\u0cb2\u0cbf \u0caa\u0ccd\u0cb0\u0cca\u0c9c\u0cc6\u0cb0\u0cbf\u0ca8\u0ccd \u0c85\u0ca8\u0ccd\u0ca8\u0cc1 \u0c97\u0cc1\u0cb0\u0cbf\u0caa\u0ca1\u0cbf\u0cb8\u0cc1\u0ca4\u0ccd\u0ca4\u0ca6\u0cc6.<\/p>\n<p>\u0caa\u0ccd\u0cb0\u0ca4\u0cbf \u0c85\u0ca7\u0ccd\u0caf\u0caf\u0ca8\u0cb5\u0cc1 \u0cb5\u0cbf\u0cad\u0cbf\u0ca8\u0ccd\u0ca8 \u0c94\u0cb7\u0ca7 \u0cb5\u0cbf\u0ca4\u0cb0\u0ca3\u0cbe \u0cb5\u0ccd\u0caf\u0cb5\u0cb8\u0ccd\u0ca5\u0cc6\u0caf\u0ca8\u0ccd\u0ca8\u0cc1 \u0cac\u0cb3\u0cb8\u0cbf\u0ca6\u0cb0\u0cc2, \u0c8e\u0cb0\u0ca1\u0cc2 \u0c85\u0ca7\u0ccd\u0caf\u0caf\u0ca8\u0c97\u0cb3\u0cc1 \u0c92\u0c82\u0ca6\u0cc7 \u0cae\u0cc2\u0cb2\u0cad\u0cc2\u0ca4 \u0c9a\u0cbf\u0c95\u0cbf\u0ca4\u0ccd\u0cb8\u0cbe \u0ca4\u0c82\u0ca4\u0ccd\u0cb0\u0cb5\u0ca8\u0ccd\u0ca8\u0cc1 \u0c97\u0cc1\u0cb0\u0cbf\u0caf\u0cbe\u0c97\u0cbf\u0cb8\u0cbf\u0c95\u0cca\u0c82\u0ca1\u0cb5\u0cc1, \u0c85\u0cb8\u0cb9\u0c9c \u0caa\u0ccd\u0cb0\u0ccb\u0c9f\u0cc0\u0ca8\u0ccd \u0caa\u0ccd\u0cb0\u0cca\u0c9c\u0cc6\u0cb0\u0cbf\u0ca8\u0ccd\u200c\u0c97\u0cc6 \u0c86\u0cb0\u0ccd\u200c\u0c8e\u0ca8\u0ccd\u200c\u0c8e \u0c95\u0ccb\u0ca1\u0cbf\u0c82\u0c97\u0ccd \u0c89\u0ca4\u0ccd\u0caa\u0cbe\u0ca6\u0ca8\u0cc6\u0caf\u0ca8\u0ccd\u0ca8\u0cc1 \u0ca4\u0ca1\u0cc6\u0caf\u0cc1\u0ca4\u0ccd\u0ca4\u0ca6\u0cc6. \u0c8e\u0cb0\u0ca1\u0ca8\u0ccd\u0ca8\u0cc2 \u0ca8\u0ccd\u0caf\u0cbe\u0cb7\u0ca8\u0cb2\u0ccd \u0c87\u0ca8\u0ccd\u200c\u0cb8\u0ccd\u0c9f\u0cbf\u0c9f\u0ccd\u0caf\u0cc2\u0c9f\u0ccd \u0c86\u0cab\u0ccd \u0cb9\u0cc6\u0cb2\u0ccd\u0ca4\u0ccd\u200c\u0ca8 (NIH) \u0cb8\u0c82\u0cb6\u0ccb\u0ca7\u0c95\u0cb0\u0cc1 \u0cae\u0cc1\u0ca8\u0ccd\u0ca8\u0ca1\u0cc6\u0cb8\u0cbf\u0ca6\u0cb0\u0cc1 \u0cae\u0ca4\u0ccd\u0ca4\u0cc1 \u0c87\u0c82\u0ca6\u0cc1 \u0c9c\u0cb0\u0ccd\u0ca8\u0cb2\u0ccd\u200c\u0ca8\u0cb2\u0ccd\u0cb2\u0cbf \u0caa\u0ccd\u0cb0\u0c95\u0c9f\u0cbf\u0cb8\u0cb2\u0cbe\u0c97\u0cbf\u0ca6\u0cc6 <em>\u0ca8\u0cc7\u0c9a\u0cb0\u0ccd \u0cae\u0cc6\u0ca1\u0cbf\u0cb8\u0cbf\u0ca8\u0ccd<\/em>.<\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41591-021-01274-0\">\u0c92\u0c82\u0ca6\u0cc1 \u0c85\u0ca7\u0ccd\u0caf\u0caf\u0ca8<\/a>, \u0cab\u0ccd\u0cb0\u0cbe\u0ca8\u0ccd\u0cb8\u0cbf\u0cb8\u0ccd \u0c95\u0cbe\u0cb2\u0cbf\u0ca8\u0ccd\u0cb8\u0ccd, MD, PhD, NIH \u0ca8 \u0ca8\u0cbf\u0cb0\u0ccd\u0ca6\u0cc7\u0cb6\u0c95\u0cb0 \u0ca8\u0cc7\u0ca4\u0cc3\u0ca4\u0ccd\u0cb5\u0ca6\u0cb2\u0ccd\u0cb2\u0cbf, \u0caa\u0ccd\u0cb0\u0cca\u0c9c\u0cc6\u0cb0\u0cbf\u0caf\u0cbe \u0c87\u0cb2\u0cbf\u0c97\u0cb3\u0cbf\u0c97\u0cc6 SRP2001 r \u0c8e\u0c82\u0cac \u0c94\u0cb7\u0ca7\u0cbf\u0caf\u0cca\u0c82\u0ca6\u0cbf\u0c97\u0cc6 \u0c9a\u0cbf\u0c95\u0cbf\u0ca4\u0ccd\u0cb8\u0cc6 \u0ca8\u0cc0\u0ca1\u0cc1\u0cb5\u0cc1\u0ca6\u0ca8\u0ccd\u0ca8\u0cc1 \u0ca4\u0ccb\u0cb0\u0cbf\u0cb8\u0cbf\u0ca6\u0cc6<strong>\u0cae\u0cb9\u0cbe\u0caa\u0ca7\u0cae\u0ca8\u0cbf\u0caf\u0cb2\u0ccd\u0cb2\u0cbf \u0cb9\u0cbe\u0ca8\u0cbf\u0c95\u0cbe\u0cb0\u0c95 \u0caa\u0ccd\u0cb0\u0cca\u0c9c\u0cc6\u0cb0\u0cbf\u0ca8\u0ccd \u0c8e\u0cae\u0ccd\u0c86\u0cb0\u0ccd\u0c8e\u0ca8\u0ccd\u0c8e \u0cae\u0ca4\u0ccd\u0ca4\u0cc1 \u0caa\u0ccd\u0cb0\u0ccb\u0c9f\u0cc0\u0ca8\u0ccd \u0c85\u0cad\u0cbf\u0cb5\u0ccd\u0caf\u0c95\u0ccd\u0ca4\u0cbf\u0c97\u0cc6 \u0cb6\u0cbf\u0c95\u0ccd\u0cb7\u0ca3 \u0ca8\u0cc0\u0ca1\u0cbf\u0ca4\u0cc1<\/strong>, \u0ca6\u0cc7\u0cb9\u0ca6\u0cb2\u0ccd\u0cb2\u0cbf\u0ca8 \u0cae\u0cc1\u0c96\u0ccd\u0caf \u0c85\u0caa\u0ca7\u0cae\u0ca8\u0cbf, \u0cb9\u0cbe\u0c97\u0cc6\u0caf\u0cc7 \u0c87\u0ca4\u0cb0 \u0c85\u0c82\u0c97\u0cbe\u0c82\u0cb6\u0c97\u0cb3\u0cb2\u0ccd\u0cb2\u0cbf. \u0c85\u0ca7\u0ccd\u0caf\u0caf\u0ca8\u0ca6 \u0c95\u0cca\u0ca8\u0cc6\u0caf\u0cb2\u0ccd\u0cb2\u0cbf, \u0cae\u0cb9\u0cbe\u0caa\u0ca7\u0cae\u0ca8\u0cbf\u0caf \u0c97\u0ccb\u0ca1\u0cc6\u0caf\u0cc1 \u0cac\u0cb2\u0cb5\u0cbe\u0c97\u0cbf \u0c89\u0cb3\u0cbf\u0caf\u0cbf\u0ca4\u0cc1 \u0cae\u0ca4\u0ccd\u0ca4\u0cc1 \u0c87\u0cb2\u0cbf\u0c97\u0cb3\u0cc1 \u0c92\u0c82\u0ca6\u0cc1 \u0caa\u0ccd\u0cb0\u0ca6\u0cb0\u0ccd\u0cb6\u0cbf\u0cb8\u0cbf\u0ca6\u0cb5\u0cc1 <strong>60% \u0c97\u0cbf\u0c82\u0ca4 \u0cb9\u0cc6\u0c9a\u0ccd\u0c9a\u0cbf\u0ca6 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&quot;\u0caa\u0ccd\u0cb0\u0cca\u0c9c\u0cc6\u0cb0\u0cbf\u0caf\u0cbe \u0cb9\u0cca\u0c82\u0ca6\u0cbf\u0cb0\u0cc1\u0cb5 \u0cae\u0c95\u0ccd\u0c95\u0cb3\u0cbf\u0c97\u0cc6 \u0c86\u0cb0\u0ccd\u0c8e\u0ca8\u0ccd\u0c8e \u0c9a\u0cbf\u0c95\u0cbf\u0ca4\u0ccd\u0cb8\u0cc6\u0caf\u0ca8\u0ccd\u0ca8\u0cc1 \u0cae\u0cc1\u0c82\u0ca6\u0cc1\u0cb5\u0cb0\u0cbf\u0cb8\u0cb2\u0cc1 \u0c88 \u0c85\u0ca6\u0ccd\u0cad\u0cc1\u0ca4 \u0cb8\u0c82\u0cb6\u0ccb\u0ca7\u0ca8\u0cbe \u0c97\u0cc1\u0c82\u0caa\u0cc1\u0c97\u0cb3\u0cca\u0c82\u0ca6\u0cbf\u0c97\u0cc6 \u0c95\u0cc6\u0cb2\u0cb8 \u0cae\u0cbe\u0ca1\u0cb2\u0cc1 \u0ca8\u0cbe\u0ca8\u0cc1 \u0cb0\u0ccb\u0cae\u0cbe\u0c82\u0c9a\u0ca8\u0c97\u0cca\u0c82\u0ca1\u0cbf\u0ca6\u0ccd\u0ca6\u0cc7\u0ca8\u0cc6. \u0c8e\u0cb0\u0ca1\u0cc2 \u0c85\u0ca4\u0ccd\u0caf\u0cbe\u0c95\u0cb0\u0ccd\u0cb7\u0c95 \u0caa\u0cc1\u0cb0\u0cbe\u0cb5\u0cc6-\u0ca4\u0ca4\u0ccd\u0cb5 \u0c85\u0ca7\u0ccd\u0caf\u0caf\u0ca8\u0c97\u0cb3\u0cc1, \u0cae\u0ca4\u0ccd\u0ca4\u0cc1 <strong>\u0c95\u0ccd\u0cb2\u0cbf\u0ca8\u0cbf\u0c95\u0cb2\u0ccd \u0caa\u0ccd\u0cb0\u0caf\u0ccb\u0c97\u0c97\u0cb3 \u0c95\u0ca1\u0cc6\u0c97\u0cc6 \u0cae\u0cc1\u0ca8\u0ccd\u0ca8\u0cc1\u0c97\u0ccd\u0c97\u0cb2\u0cc1 PRF \u0c89\u0ca4\u0ccd\u0cb8\u0cc1\u0c95\u0cb5\u0cbe\u0c97\u0cbf\u0ca6\u0cc6<\/strong> \u0c88 \u0c9a\u0cbf\u0c95\u0cbf\u0ca4\u0ccd\u0cb8\u0cbe \u0ca4\u0c82\u0ca4\u0ccd\u0cb0\u0c97\u0cb3\u0ca8\u0ccd\u0ca8\u0cc1 \u0c85\u0ca8\u0ccd\u0cb5\u0caf\u0cbf\u0cb8\u0cc1\u0ca4\u0ccd\u0ca4\u0ca6\u0cc6.<\/p>\n<p>&nbsp;<\/p>\n<p>\u2014<\/p>\n<p>\u0c8e\u0cb0\u0ccd\u0ca1\u0ccb\u0cb8\u0ccd, MR, \u0c95\u0ccd\u0caf\u0cbe\u0cac\u0ccd\u0cb0\u0cbe\u0cb2\u0ccd, WA, \u0ca4\u0cb5\u0cb0\u0cc6\u0c9c\u0ccd, UL\u00a0<i>\u0cae\u0ca4\u0ccd\u0ca4\u0cc1 \u0c87\u0ca4\u0cb0\u0cb0\u0cc1.<\/i>\u00a0\u0cb9\u0c9a\u0cbf\u0ca8\u0ccd\u0cb8\u0ca8\u0ccd-\u0c97\u0cbf\u0cb2\u0ccd\u0cab\u0ccb\u0cb0\u0ccd\u0ca1\u0ccd \u0caa\u0ccd\u0cb0\u0cca\u0c9c\u0cc6\u0cb0\u0cbf\u0caf\u0cbe 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