{"id":1902,"date":"2017-05-09T20:21:18","date_gmt":"2017-05-09T20:21:18","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?page_id=1902"},"modified":"2023-09-21T12:37:56","modified_gmt":"2023-09-21T16:37:56","slug":"2003-hutchinson-gilford-workshop","status":"publish","type":"page","link":"https:\/\/www.progeriaresearch.org\/ko\/2003-hutchinson-gilford-workshop\/","title":{"rendered":"2003 \ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \uc6cc\ud06c\uc20d"},"content":{"rendered":"<div><strong>\ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \uc6cc\ud06c\uc20d<\/strong><\/div>\n<div><strong>\ubca0\ub370\uc2a4\ub2e4, MD<\/strong><\/div>\n<div>\n<p><strong>2003\ub144 7\uc6d4 28-29\uc77c<\/strong><\/p>\n<div><\/div>\n<\/div>\n<div>\uc720\uc804\uc790 \ubc1c\uacac\uc758 \ubc1c\uc790\ucde8: PRF-NIH \uacf5\ub3d9 \uc6cc\ud06c\uc20d 2003 \uacfc\ud559\uc790\ub4e4\uc774 \uce58\ub8cc\ubc95\uacfc \uc644\uce58\ubc95\uc744 \uac1c\ubc1c\ud558\uae30 \uc704\ud574 \ud568\uaed8 \ub178\ub825\ud558\ub2e4<\/div>\n<p align=\"left\">\ud504\ub85c\uac8c\ub9ac\uc544 \uc720\uc804\uc790 \ubc1c\uacac \ubc1c\ud45c \ud6c4 4\uac1c\uc6d4\ub3c4 \ucc44 \uc9c0\ub098\uc9c0 \uc54a\uc544 \ubbf8\uad6d \uad6d\ub9bd\ubcf4\uac74\uc6d0 \ub178\ud654\uc5f0\uad6c\uc18c, \ud76c\uadc0\uc9c8\ud658\uad6d, \uad6d\ub9bd\uc778\uac04\uc720\uc804\uccb4\uc5f0\uad6c\uc18c\uc758 \uc9c0\uc6d0\uc744 \ubc1b\uc544 PRF\uc640 NIH\ub294 \ub180\ub77c\uc6b8 \uc815\ub3c4\ub85c \uc131\uacf5\uc801\uc778 <strong>2\ubc88\uc9f8 \ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544 <\/strong>\uc720\uc804\uc790 \ubc1c\uacac \uc774\ud6c4\uc758 \uc6cc\ud06c\uc20d. 55\uba85\uc758 \uacfc\ud559\uc790\uac00 \uc720\uc804\uc790 \ubc1c\uacac \uc774\ud6c4\uc758 \ud604\uc7ac \ub370\uc774\ud130\uc640 \uc7a0\uc7ac\uc801\uc778 \uc0c8\ub85c\uc6b4 \uc5f0\uad6c \ubc29\ud5a5\uc5d0 \ub300\ud55c \ud504\ub808\uc820\ud14c\uc774\uc158\uacfc \uc790\uadf9\uc801\uc778 \ud1a0\ub860\uc73c\ub85c \uac00\ub4dd \ucc2c \uc774 2\uc77c\uac04\uc758 \uc6cc\ud06c\uc20d\uc5d0 \ucc38\uc5ec\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<div><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.progeriaresearch.org\/assets\/images\/medical_images\/workshop-05-ALLsm.jpg\" alt=\"\" width=\"200\" height=\"56\" border=\"0\" \/><\/div>\n<div>\ucc38\uac00\uc790 \ud504\ub85c\ud544 \uc815\ubcf4<\/div>\n<div><strong>\ud06c\ub9ac\uc2a4\ud1a0\ud37c \uc624\uc2a4\ud2f4, MD<\/strong><\/div>\n<p>NIH\uc758 National Human Genome Research Institute\uc5d0\uc11c Translational Research\ub97c \uc704\ud55c \uc774\uc0ac\uc758 \uc218\uc11d \uace0\ubb38. Austin \ubc15\uc0ac\uc758 \uc791\uc5c5\uc740 \ucd5c\uadfc \uc644\uc131\ub41c \uc778\uac04 \uac8c\ub188 \uc2dc\ud000\uc2a4\uc5d0\uc11c \uc0dd\ubb3c\ud559\uc801 \ud1b5\ucc30\ub825\uacfc \uce58\ub8cc\uc801 \uc774\uc810\uc744 \ub3c4\ucd9c\ud558\uae30 \uc704\ud55c \uc5f0\uad6c \ud504\ub85c\uadf8\ub7a8\uc758 \uad6c\ud604\uc5d0 \uc911\uc810\uc744 \ub461\ub2c8\ub2e4. \ud604\uc7ac \uc9c1\uc704\uc5d0 \uc624\ub974\uae30 \uc804\uc5d0 Austin \ubc15\uc0ac\ub294 Merck Research Laboratories\uc5d0\uc11c \uac8c\ub188 \uc2e0\uacbd \uacfc\ud559 \uc774\uc0ac\ub85c \uc7ac\uc9c1\ud558\uba74\uc11c \uc5ec\ub7ec \uc2e0\uacbd\uc815\uc2e0 \uc9c8\ud658\uc5d0 \ub300\ud55c \ud45c\uc801 \uc2dd\ubcc4 \ubc0f \uc57d\ubb3c \uac1c\ubc1c \ud504\ub85c\uadf8\ub7a8\uc744 \uc9c0\ud718\ud588\uc73c\uba70, \ud2b9\ud788 DNA \ub9c8\uc774\ud06c\ub85c\uc5b4\ub808\uc774 \uae30\uc220, \uc57d\ubb3c\uc720\uc804\uccb4\ud559 \ubc0f \ubd84\uc790 \uc870\uc9c1\ud559\uc5d0\uc11c \uc815\uc2e0\ubd84\uc5f4\uc99d\uc5d0 \uc911\uc810\uc744 \ub450\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>Scott D. Berns, MD, MPH, FAAP<\/strong><br \/>\nMarch of Dimes\uc758 Chapter Programs \ubd80\uc0ac\uc7a5, Brown University School of Medicine\uc758 \uc18c\uc544\uacfc \uacb8\uc784 \uc870\uad50\uc218, Progeria Research Foundation(PRF) \uc774\uc0ac\ud68c \uba64\ubc84\uc785\ub2c8\ub2e4. \uc774\uc804\uc5d0 Berns \ubc15\uc0ac\ub294 \ubc31\uc545\uad00 \ud3a0\ub85c\uc6b0\uc2ed\uc744 \uc218\uc5ec\ubc1b\uc544 \ubbf8\uad6d \uad50\ud1b5\ubd80 \uc7a5\uad00\uc758 \ud2b9\ubcc4 \ubcf4\uc88c\uad00\uc73c\ub85c \uc7ac\uc9c1\ud588\uc2b5\ub2c8\ub2e4. Berns \ubc15\uc0ac\ub294 American Academy of Pediatrics\uc758 \ud3a0\ub85c\uc6b0\uc774\uba70 Genetic Alliance, National Healthy Mothers, Healthy Babies Coalition\uc758 \uc774\uc0ac\ud68c\uc5d0\uc11c \ud65c\ub3d9\ud588\uc2b5\ub2c8\ub2e4. Berns \ubc15\uc0ac\ub294 American Academy of Pediatrics, National Highway Traffic Safety Administration, \ubbf8\uad6d \uad50\ud1b5\ubd80 \uc7a5\uad00 Norman Mineta\ub85c\ubd80\ud130 \uc0c1\uc744 \ubc1b\uc558\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>W. Ted Brown, MD, PhD, FACMG<\/strong><br \/>\n\ub274\uc695 \uc8fc\ub9bd \uae30\ucd08 \uc5f0\uad6c\uc18c\uc758 \uc778\uac04 \uc720\uc804\ud559\uacfc \uc704\uc6d0\uc7a5\uc774\uc790 \uc870\uc9c0 A. \uc800\ube44\uc2a4 \ud074\ub9ac\ub2c9\uc758 \uc774\uc0ac\uc785\ub2c8\ub2e4. \uadf8\ub294 PRF \uc774\uc0ac\ud68c\uc640 \uc758\ud559 \uc5f0\uad6c \uc704\uc6d0\ud68c\uc758 \ucc3d\ub9bd \uba64\ubc84\uc600\uc2b5\ub2c8\ub2e4. \uc758\ub300\uc0dd \uc2dc\uc808, \ube0c\ub77c\uc6b4 \ubc15\uc0ac\ub294 \ud504\ub85c\uac8c\ub9ac\uc544\uc640 \ub178\ud654\uc640\uc758 \uad00\uacc4\uc5d0 \uad00\uc2ec\uc744 \uac16\uac8c \ub418\uc5c8\uace0, \uc774\ub85c \uc778\ud574 \ud504\ub85c\uac8c\ub9ac\uc544 \uc138\ud3ec\uc758 DNA \ubcf5\uad6c \uc774\uc0c1\uc5d0 \ub300\ud55c \ucd08\uae30 \uc5f0\uad6c\uac00 \uc2dc\uc791\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uadf8\ub294 \uad6d\uc81c \ud504\ub85c\uac8c\ub9ac\uc544 \ub4f1\ub85d\ubd80\ub97c \uc124\ub9bd\ud558\uc5ec 25\ub144 \ub3d9\uc548 \uc57d 60\uac74\uc758 \uc0ac\ub840\ub97c \uc870\uc0ac\ud588\uc2b5\ub2c8\ub2e4. \uc5ec\ub7ec \ud504\ub85c\uac8c\ub9ac\uc544 \uc138\ud3ec\uc8fc\uc5d0 \ub300\ud55c \uadf8\uc758 \uc138\ud3ec \uc740\ud589\uacfc \uc5fc\uc0c9\uccb4 1\uacfc \uad00\ub828\ub41c \uc7ac\ubc30\uc5f4\uc774 \uc788\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub09c \uc77c\ub780\uc131 \uc30d\ub465\uc774\uc5d0 \ub300\ud55c \uadf8\uc758 \uc5f0\uad6c\ub294 \uacb0\uad6d \ud504\ub85c\uac8c\ub9ac\uc544\uc5d0\uc11c LMNA \ub3cc\uc5f0\ubcc0\uc774\ub97c \uc2dd\ubcc4\ud558\ub294 \ub370 \uae30\uc5ec\ud588\uc2b5\ub2c8\ub2e4. \uc758\ud559 \uc720\uc804\ud559\uc790\ub85c\uc11c \uadf8\uc758 \uc5f0\uad6c \ucd08\uc810\uc740 \uc5f0\uc57d X \uc99d\ud6c4\uad70\uacfc \ubc1c\ub2ec \uc7a5\uc560 \uc720\uc804\ud559\uc5d0 \ub9de\ucdb0\uc838 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>\uc8fc\ub514\uc2a4 \ucea0\ud53c\uc2dc \ubc15\uc0ac <\/strong><br \/>\n\ub85c\ub80c\uc2a4 \ubc84\ud074\ub9ac \uad6d\ub9bd \uc5f0\uad6c\uc18c\uc758 \uc218\uc11d \uacfc\ud559\uc790\uc774\uc790 Buck Institute for Age Research\uc758 \uad50\uc218\uc785\ub2c8\ub2e4. \ucea0\ud53c\uc2dc \ubc15\uc0ac\uc758 \uc5f0\uad6c\ub294 \ub178\ud654\uc758 \ubd84\uc790\uc801, \uc138\ud3ec\uc801 \uae30\ucd08\uc640 \uc554 \ubc1c\ubcd1\uc5d0\uc11c \ub178\ud654\uc758 \uc5ed\ud560\uc744 \uc774\ud574\ud558\ub294 \ub370 \uc911\uc810\uc744 \ub450\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\ub140\ub294 \uc5f0\uad6c \uae30\uc5ec\uc5d0 \ub300\ud55c \uc5ec\ub7ec \uc0c1\uc744 \uc218\uc0c1\ud588\uc73c\uba70 \uc5ec\ub7ec \uc790\ubb38 \ubc0f \ud3b8\uc9d1 \uc704\uc6d0\ud68c\uc5d0\uc11c \ud65c\ub3d9\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>\uc548\uc824\ub77c M. \ud06c\ub9ac\uc2a4\ud2f0\uc544\ub178, \ubc15\uc0ac<\/strong><br \/>\n\uceec\ub7fc\ube44\uc544 \ub300\ud559\uad50 \ud53c\ubd80\uacfc \ubc0f \uc720\uc804\ud559 \ubc0f \uac1c\ubc1c\ud559\uacfc \ubd80\uad50\uc218, \ud53c\ubd80\uacfc \uc5f0\uad6c \ucc45\uc784\uc790.<\/p>\n<p><strong>\ud504\ub79c\uc2dc\uc2a4 S. \ucf5c\ub9b0\uc2a4, MD, PhD<\/strong><br \/>\nNIH\uc758 National Human Genome Research Institute \uc18c\uc7a5. Collins \ubc15\uc0ac\ub294 \uc804\uccb4 \uc778\uac04 DNA\ub97c \ub9e4\ud551\ud558\uace0 \uc2dc\ud000\uc2f1\ud558\uace0 \uae30\ub2a5\uc758 \ub2e8\uba74\uc744 \uacb0\uc815\ud558\ub294 \uc778\uac04 \uac8c\ub188 \ud504\ub85c\uc81d\ud2b8\ub97c \uac10\ub3c5\ud560 \ucc45\uc784\uc774 \uc788\uc2b5\ub2c8\ub2e4. \uc644\uc131\ub41c \uc2dc\ud000\uc2a4\ub294 2003\ub144 4\uc6d4\uc5d0 \uacf5\uac1c\ub418\uc5c8\uace0 \ubaa8\ub4e0 \ub370\uc774\ud130\ub294 \uacfc\ud559\uacc4\uc5d0 \uacf5\uac1c\ub418\uc5c8\uc2b5\ub2c8\ub2e4. Collins \ubc15\uc0ac\uc758 \uc5f0\uad6c\ub294 \ub0ad\ud3ec\uc131 \uc12c\uc720\uc99d, \uc2e0\uacbd\uc12c\uc720\uc885\uc99d, \ud5cc\ud305\ud134\ubcd1, \uadf8\ub9ac\uace0 \uac00\uc7a5 \ucd5c\uadfc\uc5d0\ub294 Hutchinson-Gilford Progeria Syndrome(HGPS)\uc744 \ub2f4\ub2f9\ud558\ub294 \uc720\uc804\uc790\ub97c \uc2dd\ubcc4\ud558\ub294 \ub370 \uc774\ub974\ub800\uc2b5\ub2c8\ub2e4. Collins \ubc15\uc0ac\ub294 \ub610\ud55c Institute of Medicine\uacfc National Academy of Sciences\uc758 \ud68c\uc6d0\uc785\ub2c8\ub2e4.<\/p>\n<p><strong>\ub9c8\ub9ac\uc544 \ub85c\uc0ac\ub9ac\uc544 \ub2e4\ud53c\uc2a4 \ubc15\uc0ac<\/strong><br \/>\n\uc774\ud0c8\ub9ac\uc544 \ub85c\ub9c8\uc5d0 \uc788\ub294 Tor Vergata University&#039;s School of Medicine\uc758 Prof. Novelli\uc758 \uc778\uac04 \uc720\uc804\ud559 \uc5f0\uad6c\uc2e4\uc758 \uacfc\ud559\uc790. Dr. Rosaria\uc758 \uc5f0\uad6c\ub294 Mandibuloacral Dysplasia(MAD)\uc640 HGPS\uc758 LMNA \uc720\uc804\uc790 \ub3cc\uc5f0\ubcc0\uc774 \ubd84\uc11d\uc5d0 \uc9d1\uc911\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\ub140\uc758 \ubaa9\ud45c\ub294 LMNA \uc720\uc804\uc790\uc88c\uc640 \uc5f0\uacb0\ub418\uc9c0 \uc54a\uc740 \ud608\ud1b5\uc5d0\uc11c MAD\ub97c \uc720\ubc1c\ud558\ub294 \uc720\uc804\uc790\uc640 LMNA \ub3cc\uc5f0\ubcc0\uc774\uac00 \uc788\ub294 MAD \uc12c\uc720\uc544\uc138\ud3ec\uc758 \uc870\uc9c1 \ud2b9\uc774\uc801 \uc138\ud3ec \uacbd\ub85c\uc5d0 \ucc38\uc5ec\ud558\ub294 \uc720\uc804\uc790\ub97c \uc2dd\ubcc4\ud558\ub294 \uac83\uc785\ub2c8\ub2e4.<\/p>\n<p><strong>\uce74\ub9ac\ub9c8 \uc790\ubc1c\ub9ac \ubc15\uc0ac<\/strong><br \/>\n\uceec\ub7fc\ube44\uc544 \ub300\ud559\uad50 \ud53c\ubd80\uacfc \uc870\uad50\uc218. Djabali \ubc15\uc0ac\uc758 \uc5f0\uad6c \uad00\uc2ec\uc0ac\ub294 \ud06c\ub85c\ub9c8\ud2f4 \uc870\uc9c1, \uc720\uc804\uc790 \ubc1c\ud604, \uc138\ud3ec \uc131\uc7a5 \ubc0f \ubd84\ud654\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \ud575 \uae30\uc9c8 \uad6c\ud68d\uc785\ub2c8\ub2e4. Djabali \ubc15\uc0ac\ub294 \ud53c\ubd80\ub97c \ubaa8\ub378 \uc2dc\uc2a4\ud15c\uc73c\ub85c \uc0ac\uc6a9\ud558\uc5ec \ud575 \uae30\uc9c8 \uad6c\uc131 \uc694\uc18c\ub97c \uc774\ud574\ud558\uace0 \uc720\uc804\uc801 \ubc0f \ud504\ub85c\ud14c\uc624\ubbf9 \uc811\uadfc \ubc29\uc2dd\uc744 \uacb0\ud569\ud558\uc5ec \uc138\ud3ec \uc131\uc7a5 \ubc0f \ubd84\ud654 \uc911 \ub2e8\ubc31\uc9c8 \ubc1c\ud604 \ud504\ub85c\ud544\uc744 \ub530\ub985\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ud575 \uae30\uc9c8 \ub2e8\ubc31\uc9c8 \uc911 \ud558\ub098\ub77c\ub3c4 \uc798\ubabb \ubc1c\ud604\ub418\uba74 \ud575 \uad6c\uc870, \ud06c\ub85c\ub9c8\ud2f4 \ub9ac\ubaa8\ub378\ub9c1 \ubc0f \uc720\uc804\uc790 \ubc1c\ud604\uc774 \uc2ec\uac01\ud558\uac8c \uc190\uc0c1\ub418\uc5b4 \ud2b9\uc815 \uc720\ud615\uc758 \uc554 \ubc0f \uce35\uc0c1\ubcd1\uc99d\uacfc \uac19\uc740 \ud2b9\uc815 \uc7a5\uc560\uac00 \ubc1c\uc0dd\ud569\ub2c8\ub2e4.<\/p>\n<p><strong>\ub9c8\ub9ac\uc544 \uc5d0\ub9ad\uc2a8 \ubc15\uc0ac<\/strong><br \/>\nNIH\uc758 National Human Genome Research Institute\uc5d0\uc11c Dr. Collins\uc758 \uc5f0\uad6c\uc2e4\uc5d0\uc11c \ubc15\uc0ac\ud6c4 \uc5f0\uad6c\uc6d0. Dr. Eriksson\uc740 HGPS\uc758 \uc6d0\uc778\uc778 \uc720\uc804\uc790 \uacb0\ud568\uc744 \uc124\uba85\ud558\ub294 \ucd5c\uadfc Nature \ub17c\ubb38\uc758 \uc8fc\uc694 \uc800\uc790\uc785\ub2c8\ub2e4.<\/p>\n<p><strong>\ud074\ub808\uc5b4 A. \ud504\ub791\ucf54\ub9c8\ub178, MD <\/strong><br \/>\n\uc120\uc784 \uc5f0\uad6c\uc6d0 \uacb8 \uc778\uac04 \uc720\uc804\ud559 \ubc0f \ud1b5\ud569 \uc758\ud559 \ubd80\ubb38 \ucc45\uc784\uc790, \uc720\uc804\ud559 \uc5f0\uad6c\uc18c, \uad6d\ub9bd \ub178\ud654 \uc5f0\uad6c\uc18c. Francomano \ubc15\uc0ac\uc758 \uc5f0\uad6c\uc2e4\uc740 \uc12c\uc720\uc544\uc138\ud3ec \uc131\uc7a5 \uc778\uc790 \uc218\uc6a9\uccb4 3\uc758 \ub3cc\uc5f0\ubcc0\uc774\ub85c \uc778\ud55c \uc778\uac04 \uc9c8\ubcd1\uc5d0 \ub300\ud55c \ub9c8\uc6b0\uc2a4 \ubaa8\ub378 \uc0dd\uc131\uacfc \uc5f0\uace8 \ubc0f \uc5f0\uace8 \uc138\ud3ec \uc0dd\ubb3c\ud559\uc744 \uc5f0\uad6c\ud558\uae30 \uc704\ud55c \uc2dc\ud5d8\uad00 \ub0b4 \ubc29\ubc95 \uac1c\ubc1c\uc5d0 \uc911\uc810\uc744 \ub450\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\ub140\ub294 \ub610\ud55c Marfan \uc99d\ud6c4\uad70, Stickler \uc99d\ud6c4\uad70 \ubc0f Ehlers-Danlos \uc99d\ud6c4\uad70\uc758 \uc790\uc5f0\uc0ac\ub97c \uc5f0\uad6c\ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub140\ub294 \uc5ec\ub7ec \uc790\ubb38 \uc704\uc6d0\ud68c\uc5d0 \ucc38\uc5ec\ud558\uace0 \uc788\uc73c\uba70 \uad6d\uc81c \uace8\uaca9\uc131 \uc774\ud615\uc131\uc99d \ud559\ud68c \ud68c\uc7a5\uc785\ub2c8\ub2e4.<\/p>\n<p><strong>\ud1a0\ub9c8\uc2a4 W. \uae00\ub85c\ubc84, \ubc15\uc0ac <\/strong><br \/>\n\ubbf8\uc2dc\uac04 \ub300\ud559\uad50 \uc778\uac04 \uc720\uc804\ud559\uacfc\uc758 \uc218\uc11d \uc5f0\uad6c\uc6d0. Glover \ubc15\uc0ac\uc758 \uc5f0\uad6c \uad00\uc2ec\uc0ac\ub294 \uc778\uac04 \uc720\uc804 \uc9c8\ud658\uacfc \uc5fc\uc0c9\uccb4 \ubd88\uc548\uc815\uc131\uc758 \ubd84\uc790\uc801 \uae30\ucd08\uc785\ub2c8\ub2e4. \uadf8\uc758 \uc5f0\uad6c\uc2e4\uc740 \ucde8\uc57d\ud55c \ubd80\uc704\uc758 \uc5fc\uc0c9\uccb4 \ubd88\uc548\uc815\uc131\uc744 \uc5f0\uad6c\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. Glover \ubc15\uc0ac\uc758 \uc5f0\uad6c\ub294 \uc720\uc804\uc131 \ub9bc\ud504\ubd80\uc885\uc744 \ub2f4\ub2f9\ud558\ub294 \uc720\uc804\uc790\ub97c \ud3ec\ud568\ud558\uc5ec \uc5ec\ub7ec \uc778\uac04 \uc9c8\ubcd1 \uc720\uc804\uc790\ub97c \uc2dd\ubcc4\ud558\uace0 \ubcf5\uc81c\ud588\uc2b5\ub2c8\ub2e4. Glover \ubc15\uc0ac\ub294 HGPS\ub97c \ub2f4\ub2f9\ud558\ub294 \ub77c\ubbfc A \uc720\uc804\uc790\ub97c \uc2dd\ubcc4\ud558\uae30 \uc704\ud55c \ud611\ub825 \ub178\ub825\uc5d0 \ucc38\uc5ec\ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub294 \ud604\uc7ac \ub77c\ubbfc A\uc758 \ub3cc\uc5f0\ubcc0\uc774\uac00 \ud504\ub85c\uac8c\ub9ac\uc544 \ud45c\ud604\ud615\uc73c\ub85c \uc774\uc5b4\uc9c0\ub294 \uc774\uc720\uc5d0 \ub300\ud55c \uc758\ubb38\uc744 \ub2e4\ub8e8\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>\ub9c8\uc774\ud074 W. \uae00\ub9b0, MS<\/strong><br \/>\nUniversity of Michigan\uc5d0\uc11c \uc778\uac04 \uc720\uc804\ud559 \ubc15\uc0ac\uacfc\uc815\uc744 \ubc1f\uace0 \uc788\ub294 \uc120\uc784 \ud559\uc0dd\uc785\ub2c8\ub2e4. \uadf8\ub294 \ubc15\uc0ac \uacfc\uc815\uc5d0\uc11c Progeria\uc5d0 \uc9d1\uc911\ud588\uc73c\uba70, \ucd5c\uadfc HGPS \uc5f0\uad6c\ub97c \uacc4\uc18d\ud558\uae30 \uc704\ud574 University of Michigan Rackham Graduate Student Fellowship\uc744 \ub0b4\ub144\uc5d0 \uc218\uc5ec\ubc1b\uc558\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>\ub85c\ubc84\ud2b8 D. \uace8\ub4dc\uba3c \ubc15\uc0ac<\/strong><br \/>\nStephen Walter Ranson Northwestern University Medical School\uc758 \uc138\ud3ec \ubc0f \ubd84\uc790 \uc0dd\ubb3c\ud559 \uad50\uc218 \uacb8 \ud559\uacfc\uc7a5. Goldman \ubc15\uc0ac\uc758 \uc5f0\uad6c\ub294 \uc138\ud3ec \uc8fc\uae30 \ub3d9\uc548 \ud575 \ub77c\ubbfc\uc758 \uc5ed\ud559\uc5d0 \ucd08\uc810\uc744 \ub9de\ucd94\uace0 \uad6c\uc870\uc640 \uae30\ub2a5 \uac04\uc758 \uad00\uacc4\ub97c \uc870\uc0ac\ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub294 \uc138\ud3ec \uae30\ub2a5 \ubc0f \uc0c1\ud638 \uc791\uc6a9\uc5d0 \ub300\ud55c \ubd84\uc790\uc801 \uc811\uadfc\uc758 NIH \ud68c\uc6d0\uc774\uba70 Juvenile Diabetes Foundation\uc758 \uc778\uac04 \ubc30\uc544\uc904\uae30\uc138\ud3ec \uc790\ubb38 \uc704\uc6d0\ud68c\uc5d0\uc11c \ud65c\ub3d9\ud569\ub2c8\ub2e4. \uadf8\ub294 Woods Hole\uc758 Marine Biological Laboratory\uc5d0\uc11c \uc138\ud3ec \ubc0f \ubd84\uc790 \uc0dd\ubb3c\ud559 \uac15\uc0ac \ubc0f \ucc45\uc784\uc790\ub85c \uc77c\ud588\uc2b5\ub2c8\ub2e4. Goldman \ubc15\uc0ac\ub294 \ubc1c\ub2ec \ubc0f \uc9c8\ubcd1\uc5d0\uc11c \ud575 \uc870\uc9c1\uc5d0 \ub300\ud55c Novartis \uc2ec\ud3ec\uc9c0\uc5c4\uc758 \uc758\uc7a5\uc744 \ub9e1\uc744 \uc608\uc815\uc785\ub2c8\ub2e4.<\/p>\n<p><strong>\uc2a4\ud2f0\ube10 \uace8\ub4dc\uba3c \ubc15\uc0ac<\/strong><br \/>\n\uad6d\ub9bd\ubcf4\uac74\uc6d0 \uc2ec\uc7a5\ud608\uad00\uc9c8\ud658\ubd80 \uad6d\ub9bd\uc2ec\uc7a5\ud3d0\ud608\uc561\uc5f0\uad6c\uc18c\uc758 \uac74\uac15\uacfc\ud559 \uad00\ub9ac\uc790\uc785\ub2c8\ub2e4.<\/p>\n<p><strong>\uc694\uc149 \uadf8\ub8e8\uc5d4\ubc14\uc6c0 \ubc15\uc0ac<\/strong><br \/>\n\uc608\ub8e8\uc0b4\ub818 \ud788\ube0c\ub9ac \ub300\ud559\uad50 \uc720\uc804\ud559 \uad50\uc218 \uacb8 \uc720\uc804\ud559 \ud559\uacfc\uc7a5. \ud604\uc7ac Dr. Gruenbaum\uc740 \ub178\uc2a4\uc6e8\uc2a4\ud134 \ub300\ud559\uad50\uc758 \ubc29\ubb38 \uad50\uc218\uc785\ub2c8\ub2e4. \uadf8\uc758 \uc5f0\uad6c\uc5d0\ub294 \uc9c4\ud575 \uc138\ud3ec\uc758 DNA \uba54\ud2f8\ud654 \uba54\ucee4\ub2c8\uc998\uc774 \ud3ec\ud568\ub418\uba70, \uadf8\ub294 \uc7ac\ub8cc \uacfc\ud559, \ud654\ud559 \ubc0f \ubb3c\ub9ac\ud559 \ubd84\uc57c\uc5d0\uc11c \uacbd\ub825\uc744 \uc313\uc558\uc2b5\ub2c8\ub2e4. \ucd5c\uadfc\uc5d0 \uadf8\ub294 Gruss-Lipper \ud3a0\ub85c\uc6b0\uc2ed\uc744 \uc218\uc0c1\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>\uc624\ub4dc\ub9ac \uace0\ub4e0, \ubcc0\ud638\uc0ac<\/strong><br \/>\nThe Progeria Research Foundation(PRF)\uc758 \ucc3d\ub9bd \ud68c\uc7a5 \uacb8 \uc804\ubb34 \uc774\uc0ac\ub85c, HGPS\uc758 \uc6d0\uc778\uc744 \ubc1c\uacac\ud558\uace0 \uce58\ub8cc\ubc95\uacfc \uc644\uce58\ubc95\uc744 \uac1c\ubc1c\ud558\ub294 \uac83\uc744 \uc0ac\uba85\uc73c\ub85c \ud569\ub2c8\ub2e4. Ms. Gordon\uc740 1988\ub144\ubd80\ud130 \ub9e4\uc0ac\ucd94\uc138\uce20\uc640 \ud50c\ub85c\ub9ac\ub2e4\uc5d0\uc11c \ubcc0\ud638\uc0ac \uc790\uaca9\uc744 \ucde8\ub4dd\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>Leslie B. Gordon, MD, PhD <\/strong><br \/>\n\ub85c\ub4dc\uc544\uc77c\ub79c\ub4dc \uc8fc \ud504\ub85c\ube44\ub358\uc2a4\uc5d0 \uc788\ub294 \ube0c\ub77c\uc6b4 \ub300\ud559\uad50 \uc758\uacfc\ub300\ud559 \uc18c\uc544\uacfc \uc870\uad50\uc218\uc774\uc790 \ub9e4\uc0ac\ucd94\uc138\uce20 \uc8fc \ubcf4\uc2a4\ud134\uc5d0 \uc788\ub294 \ud130\ud504\uce20 \ub300\ud559\uad50 \uc758\uacfc\ub300\ud559 \ud574\ubd80\ud559 \ubc0f \uc138\ud3ec\uc0dd\ubb3c\ud559 \uc870\uad50\uc218\ub85c HGPS\uc5d0 \ub300\ud55c \uae30\ucd08 \uacfc\ud559 \uc5f0\uad6c\ub97c \uc218\ud589\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\ub140\ub294 PRF\uc758 \uc758\ub8cc \ucc45\uc784\uc790\uc774\uba70 \ud504\ub85c\uac8c\ub9ac\uc544\ub97c \uc553\uace0 \uc788\ub294 \uc544\uc774\uc758 \ubd80\ubaa8\uc785\ub2c8\ub2e4. \uadf8\ub140\ub294 \ub610\ud55c PRF \uc138\ud3ec \ubc0f \uc870\uc9c1 \uc740\ud589, PRF \uc758\ud559 \ubc0f \uc5f0\uad6c \ub370\uc774\ud130\ubca0\uc774\uc2a4, PRF \uc9c4\ub2e8 \ud504\ub85c\uadf8\ub7a8\uc758 \uc8fc\uc694 \uc5f0\uad6c\uc6d0\uc774\uae30\ub3c4 \ud569\ub2c8\ub2e4.<\/p>\n<p><strong>\uc2a4\ud2f0\ube10 C. \uadf8\ub85c\ud504\ud2b8, \uc57d\ud559\ubc15\uc0ac<\/strong><br \/>\n\uad6d\ub9bd\ubcf4\uac74\uc6d0(NIH) \ud76c\uadc0\uc9c8\ud658\uad6d \uad6d\uc7a5. Groft \ubc15\uc0ac\ub294 \ud658\uc790 \uc9c0\uc6d0 \uadf8\ub8f9\uacfc \ud611\ub825\ud558\uc5ec \uc9c8\ubcd1 \uc5f0\uad6c\ub97c \ucd09\uc9c4\ud558\ub294 \ub370 \uc8fc\ub825\ud588\uc2b5\ub2c8\ub2e4. \uadf8\uc758 \uc0ac\ubb34\uc2e4\uc740 \uad6d\ub9bd\ubcf4\uac74\uc6d0(NIH) \uc5f0\uad6c \uae30\uad00 \ubc0f \uc13c\ud130\uc640 \ud658\uc790 \uc9c0\uc6d0 \uadf8\ub8f9\uacfc \ud568\uaed8 380\uac1c\uac00 \ub118\ub294 \uacfc\ud559 \uc6cc\ud06c\uc20d\uacfc \uc2ec\ud3ec\uc9c0\uc5c4\uc744 \uacf5\ub3d9 \ud6c4\uc6d0\ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub294 \ucd5c\uadfc \ubc31\uc545\uad00 \ubcf4\uc644 \ubc0f \ub300\uccb4 \uc758\ud559 \uc815\ucc45 \uc704\uc6d0\ud68c\uc758 \uc804\ubb34 \uc774\uc0ac\ub85c \uc784\uba85\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uadf8\ub294 \uad6d\ub9bd\ubcf4\uac74\uc6d0(NIH)\uc5d0 \ub300\uccb4 \uc758\ud559\uad6d\uc744 \uc124\ub9bd\ud588\uace0 \ubcf4\uac74\ubcf5\uc9c0\ubd80\uc5d0\uc11c \ud76c\uadc0\uc9c8\ud658 \uad6d\uac00 \uc704\uc6d0\ud68c\uc758 \uc804\ubb34 \uc774\uc0ac\ub85c \uadfc\ubb34\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>\uc6e8\uc778 \ud558\uac90 <\/strong><br \/>\nUniversity of California, Irvine\uc758 \ud559\ubd80 4\ud559\ub144 \ud559\uc0dd\uc785\ub2c8\ub2e4. Hagen \uc528\ub294 \uc0dd\ud654\ud559\uacfc \ubd84\uc790\uc0dd\ubb3c\ud559\uc5d0 \uc9d1\uc911\ud558\uc5ec \uc5f0\uad6c\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\ub294 \ub610\ud55c National Human Genome Research Institute\uc758 Collin \ubc15\uc0ac \uc5f0\uad6c\uc2e4\uc5d0\uc11c HGPS\ub97c \uc5f0\uad6c\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>\uadf8\ub808\uace0\ub9ac \ud574\ub10c \ubc15\uc0ac<\/strong><br \/>\n\ucf5c\ub4dc \uc2a4\ud504\ub9c1 \ud558\ubc84 \uc5f0\uad6c\uc18c\uc758 \uc653\uc2a8 \uc0dd\ubb3c\ud559 \ub300\ud559 \uad50\uc218. \ud574\ub10c \ubc15\uc0ac\uc758 \uc5f0\uad6c\ub294 \uc774\uc911 \uac00\ub2e5 RNA \uc720\ub3c4 \uc720\uc804\uc790 \uce68\ubb35 \ub610\ub294 RNAi\uc5d0 \uc911\uc810\uc744 \ub450\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\uc758 \uc5f0\uad6c\ub294 \uc774 \ud604\uc0c1\uc758 \uc0dd\ud654\ud559\uc801 \uba54\ucee4\ub2c8\uc998\uc744 \uc774\ud574\ud558\ub294 \ub370 \uc911\uc810\uc744 \ub450\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \uae30\uacc4\uc758 \uc0c8\ub85c\uc6b4 \uc694\uc18c\ub97c \uc2dd\ubcc4\ud558\uba74 RNAi \uacbd\ub85c\uc758 \uc0dd\ubb3c\ud559\uc801 \uae30\ub2a5\uc5d0 \ub300\ud55c \ub354 \uae4a\uc740 \uc774\ud574\uc640 \ud3ec\uc720\ub958 \uc720\uc804\ud559\uc5d0\uc11c \uc0ac\uc6a9\ud560 \uc218 \uc788\ub294 \ub354 \ub098\uc740 RNAi \uae30\ubc18 \ub3c4\uad6c\uc758 \uac1c\ubc1c\ub85c \uc774\uc5b4\uc9c0\uace0 \uad81\uadf9\uc801\uc73c\ub85c RNAi\ub97c \uce58\ub8cc\uc801 \uc811\uadfc \ubc29\uc2dd\uc73c\ub85c \uc801\uc6a9\ud558\uac8c \ub420 \uac83\uc785\ub2c8\ub2e4.<\/p>\n<p><strong>\ud5e4\ub354 \ud558\ub514, MD<\/strong><br \/>\n\ub9e4\uc0ac\ucd94\uc138\uce20\uc8fc \uc560\ud2c0\ubc84\ub7ec\uc5d0 \uc788\ub294 \uc2a4\ud130\ub514 \uba54\ubaa8\ub9ac\uc5bc \ubcd1\uc6d0\uc758 \uadfc\uace8\uaca9\uacc4 \uc601\uc0c1\uacfc\uc7a5, \ubc29\uc0ac\uc120\uacfc \uc8fc\uce58\uc758. \ud558\ub514 \ubc15\uc0ac\ub294 \ub9e4\uc0ac\ucd94\uc138\uce20\uc8fc \ubcf4\uc2a4\ud134\uc5d0 \uc788\ub294 \ub9e4\uc0ac\ucd94\uc138\uce20 \uc885\ud569\ubcd1\uc6d0\uc5d0\uc11c \uadfc\uace8\uaca9\uacc4 \uc601\uc0c1\uacfc \uc804\ubb38\uc758\uc785\ub2c8\ub2e4.<\/p>\n<p><strong>\ud06c\ub9ac\uc2a4\ud2f4 J. \ud560\ub9c1-\ubc84\uadf8(Christine J. Harling-Berg) \ubc15\uc0ac<\/strong><br \/>\n\ube0c\ub77c\uc6b4 \ub300\ud559\uad50 \uc758\uacfc\ub300\ud559 \ubc0f \ub85c\ub4dc\uc544\uc77c\ub79c\ub4dc \uba54\ubaa8\ub9ac\uc5bc \ubcd1\uc6d0 \uc18c\uc544\uacfc \uc870\uad50\uc218(\uc5f0\uad6c). Harling-Berg \ubc15\uc0ac\ub294 PRF \uc758\ud559 \uc5f0\uad6c \uc704\uc6d0\ud68c\uc758 \ucc3d\ub9bd \uba64\ubc84\uc785\ub2c8\ub2e4. \uadf8\ub140\uc758 \uc5f0\uad6c\ub294 \ub1cc\uc758 \ub2e8\ubc31\uc9c8\uc5d0 \ub300\ud55c \uba74\uc5ed \ubc18\uc751\uc744 \uc5f0\uad6c\ud558\uace0 \ub1cc\/\uba74\uc5ed \uccb4\uacc4 \uc0c1\ud638\uc791\uc6a9\uc758 TH2 \ud3b8\ud5a5 \uba74\uc5ed \ubc18\uc751\uc744 \ubc1d\ud788\uae30 \uc704\ud55c \ub3d9\ubb3c \ubaa8\ub378\uc744 \uac1c\ubc1c\ud558\ub294 \ub370 \uc911\uc810\uc744 \ub450\uc5c8\uc2b5\ub2c8\ub2e4. \ucd5c\uadfc\uc5d0\ub294 \uad50\ucc28 \ubc18\uc751\uc131 \ud56d\uc2e0\uacbd \ud56d\uccb4\uac00 \ub1cc \uae30\ub2a5\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \uc5f0\uad6c\ud588\uc2b5\ub2c8\ub2e4. Harling-Berg \ubc15\uc0ac\ub294 \uc6b0\uc988\ud640\uc758 \ud574\uc591 \uc0dd\ubb3c\ud559 \uc5f0\uad6c\uc18c\uc5d0\uc11c \uac15\uc0ac\ub85c \ud65c\ub3d9\ud560 \uc608\uc815\uc785\ub2c8\ub2e4.<\/p>\n<p><strong>\uc789\uadf8\ub9ac\ub4dc \ud558\ud2bc, MS<\/strong><br \/>\nTufts University\uc758 \uc138\ud3ec, \ubd84\uc790 \ubc0f \ubc1c\ub2ec \uc0dd\ubb3c\ud559 \ud504\ub85c\uadf8\ub7a8\uc758 \ub300\ud559\uc6d0\uc0dd. Harten \uc528\uc758 \uc5f0\uad6c \ubaa9\ud45c\uc5d0\ub294 \uc2dc\ud5d8\uad00 \ub0b4 HGPS \uc12c\uc720\uc544\uc138\ud3ec\uc758 \ud45c\ud604\ud615\uc801 \ud2b9\uc131\uc744 \uacb0\uc815\ud558\uace0 \uc9c8\ubcd1\uc758 \ubcd1\ud0dc\uc0dd\ub9ac\ud559\uc5d0\uc11c \uc5b4\ub5a4 \uc5ed\ud560\uc744 \ud560 \uc218 \uc788\ub294\uc9c0\uac00 \ud3ec\ud568\ub429\ub2c8\ub2e4.<\/p>\n<p><strong>\ub9ac\ucc28\ub4dc J. \ud638\ub370\uc2a4 \ubc15\uc0ac <\/strong><br \/>\n\uad6d\ub9bd\ubcf4\uac74\uc6d0(NIH) \uc0b0\ud558 \uad6d\ub9bd\ub178\ud654\uc5f0\uad6c\uc18c(NIA) \uc18c\uc7a5, \ubcf4\uac74\ubcf5\uc9c0\ubd80. NIA\ub294 \ub178\ud654\uc758 \uae30\ubcf8\uc801, \uc784\uc0c1\uc801, \uc5ed\ud559\uc801, \uc0ac\ud68c\uc801 \uc601\ud5a5\uc5d0 \ub300\ud55c \uc5f0\uad6c\ub97c \uc704\ud55c \uc8fc\uc694 \uc5f0\ubc29 \uc790\uae08 \uc9c0\uc6d0 \uae30\uad00\uc785\ub2c8\ub2e4. Hodes \ubc15\uc0ac\ub294 1993\ub144\uc5d0 NIA \uc18c\uc7a5\uc73c\ub85c \uc784\uba85\ub418\uc5c8\uc9c0\ub9cc, \uad6d\ub9bd\uc554\uc5f0\uad6c\uc18c\uc758 \uc5f0\uad6c\uc790\ub85c\uc11c NIH\uc5d0\uc11c \uacfc\ud559 \ubd84\uc57c\uc5d0\uc11c \uc624\ub79c \uacbd\ub825\uc744 \uc313\uc558\uc2b5\ub2c8\ub2e4. Hodes \ubc15\uc0ac\ub294 NIH\uc5d0\uc11c \uba74\uc5ed \ubc18\uc751\uc758 \uc138\ud3ec \ubc0f \ubd84\uc790\uc801 \uc870\uc808\uc5d0 \ucd08\uc810\uc744 \ub9de\ucd98 \ud65c\ubc1c\ud55c \uc5f0\uad6c \ud504\ub85c\uadf8\ub7a8\uc744 \uc720\uc9c0\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\ub294 \ubbf8\uad6d \ub0b4\uacfc \uc704\uc6d0\ud68c\uc758 \uc678\uad50\uad00\uc785\ub2c8\ub2e4. Hodes \ubc15\uc0ac\ub294 Dana Alliance for Brain Initiatives, American Association for the Advancement of Science, National Academy of Sciences\uc758 Institute of Medicine\uc5d0 \uc120\ucd9c\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>\uce7c\ub808\ucf54 \ubc15\uc0ac, \ubc15\uc0ac, \uc758\ud559\ubc15\uc0ac <\/strong><br \/>\nAdvanced Vision Therapies, Inc.\uc758 \uacf5\ub3d9 \ucc3d\ub9bd\uc790. Kaleko \ubc15\uc0ac\uc758 \uc5f0\uad6c\ub294 \uc548\uacfc \uce58\ub8cc\uc5d0 \uc9d1\uc911\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4. Kaleko \ubc15\uc0ac\ub294 Genetic Therapy, Inc.\uc5d0\uc11c \ud608\uc6b0\ubcd1, \uc554 \ubc0f \uc548\uacfc \uc9c8\ud658 \uce58\ub8cc\ub97c \uc704\ud55c \uc720\uc804\uc790 \uc804\uc774 \ubca1\ud130\ub97c \uac1c\ubc1c\ud558\ub294 \ud504\ub85c\uc81d\ud2b8\ub97c \uc9c0\ud718\ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub294 \ub610\ud55c Fred Hutchinson Cancer Research Center\uc5d0\uc11c \uc720\uc804\uc790 \uce58\ub8cc \uc5f0\uad6c\ub97c \uc218\ud589\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>\uc694\ud558\ub124 \uce74\ud50c\ub780, \ubc15\uc0ac <\/strong><br \/>\nGenzyme Corporation\uc758 \uba74\uc5ed \uc694\ubc95 \ubd80\ubb38 \uc218\uc11d \uc774\uc0ac. Kaplan \ubc15\uc0ac\ub294 \uc784\uc0c1 \uc804 \uc720\uc804\uc790 \uc694\ubc95 \ubc0f \uba74\uc5ed \uc694\ubc95 \uc5f0\uad6c\uc5d0 \ucc38\uc5ec\ud588\uc2b5\ub2c8\ub2e4. \ud604\uc7ac \uc9c1\uc704\uc5d0 \uc624\ub974\uae30 \uc804\uc5d0 Kaplan \ubc15\uc0ac\ub294 SmithKline Beecham Pharmaceuticals\uc758 \uc2e4\ud5d8 \ubcd1\ub9ac\ud559\uacfc\uc5d0 \uba74\uc5ed \ub3c5\uc131\ud559 \ubd80\uc11c\ub97c \uc124\ub9bd\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>\ubaa8\ub2c8\uce74 \ud074\ub77c\uc778\ub9cc, MD <\/strong><br \/>\n\ub9e4\uc0ac\ucd94\uc138\uce20\uc8fc \ubcf4\uc2a4\ud134\uc5d0 \uc788\ub294 Children&#039;s Hospital\uc758 \uc18c\uc544 \uc911\ud658\uc790 \uc804\ubb38\uc758. \ud074\ub77c\uc778\ub9cc \ubc15\uc0ac\ub294 PRF \uc774\uc0ac\ud68c\uc758 \ucc3d\ub9bd \uba64\ubc84\uc774\uc790 PRF \uc758\ud559 \uc5f0\uad6c \uc704\uc6d0\ud68c \uc758\uc7a5\uc785\ub2c8\ub2e4. \uadf8\ub140\ub294 PRF \ubcf4\uc870\uae08 \uc2e0\uccad\uc11c \uac80\ud1a0\uc640 PRF \uc790\uae08 \uc9c0\uc6d0 \uc5f0\uad6c\uc5d0 \ub300\ud55c \uc774\uc0ac\ud68c \ubcf4\uace0\ub97c \ub2f4\ub2f9\ud569\ub2c8\ub2e4.<\/p>\n<p><strong>\ud3f4 \ub178\ud504, \ubc15\uc0ac<\/strong><br \/>\n\ube0c\ub77c\uc6b4 \ub300\ud559\uad50\uc758 \ubd84\uc790, \ubbf8\uc0dd\ubb3c \ubc0f \uba74\uc5ed\ud559\uc5d0\uc11c \uc758\ud559\uacfc \uba85\uc608\uad50\uc218\uc778 Charles A. \ubc0f Helen B. Stuart. Knopf \ubc15\uc0ac\ub294 PRF \uc758\ud559 \uc5f0\uad6c \uc704\uc6d0\ud68c\uc758 \ucc3d\ub9bd \uba64\ubc84\uc785\ub2c8\ub2e4. \uadf8\ub294 MRC \uc5f0\uad6c\uc2e4 \ubd84\uc790 \uc0dd\ubb3c\ud559\uc758 Francis Crick \uc5f0\uad6c\uc2e4\uc5d0\uc11c \uc77c\ud558\uba74\uc11c \uc2dc\ud5d8\uad00 \ub0b4\uc5d0\uc11c \uc2e0\uc0dd \ud3f4\ub9ac\ud3a9\ud0c0\uc774\ub4dc \uc0ac\uc2ac\uc758 \uc2dc\uc791\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4. \uadf8\ub294 \ub610\ud55c Salk \uc5f0\uad6c\uc18c\uc5d0\uc11c \uc77c\ud558\uba74\uc11c \uba74\uc5ed\uae00\ub85c\ubd88\ub9b0\uc758 \ud45c\uba74 \ubc1c\ud604 \ub610\ub294 \ubd84\ube44\ub85c \uc774\uc5b4\uc9c0\ub294 \uc138\ud3ec \ub0b4 \uacbd\ub85c\uc758 \ub2e8\uacc4\ub97c \ubc1d\ud600\ub0c8\uc2b5\ub2c8\ub2e4. \ube0c\ub77c\uc6b4 \ub300\ud559\uad50\uc5d0\uc11c \uadf8\uc758 \uc5f0\uad6c\uc2e4\uc740 \uc720\uc804\uc790\ub97c \ubcf5\uc81c\ud558\uace0 Schistosoma mansoni\uc758 \ud6c4\ubcf4 \ubc31\uc2e0 \ud56d\uc6d0\uc744 \ubc1c\ud604\uc2dc\ucf30\uc2b5\ub2c8\ub2e4. \ucd5c\uadfc\uc5d0\ub294 \ud608\uc561-\ub1cc \uc7a5\ubcbd \ub4a4\uc5d0\uc11c \ub1cc\ub85c \ub3c4\uc785\ub41c \ud56d\uc6d0\uc5d0 \ub300\ud55c \uba74\uc5ed \ubc18\uc751\uc744 \uc5f0\uad6c\ud558\uae30 \uc704\ud55c \ubaa8\ub378 \uc2dc\uc2a4\ud15c\uc744 \uacf5\ub3d9 \uac1c\ubc1c\ud588\uc73c\uba70, \ub1cc \uae30\ub2a5\uc5d0 \ub300\ud55c \ud56d\uc2e0\uacbd \ud56d\uccb4\uc758 \ud6a8\uacfc\ub97c \uc5f0\uad6c\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>\uc870\uc548 \ub808\ubbf8\uc5b4 \ubc15\uc0ac<\/strong><br \/>\nTufts University\uc758 \uc870\uad50\uc218(\uc5f0\uad6c). Lemire \ubc15\uc0ac\ub294 \ucd5c\uadfc HGPS\uc5d0\uc11c \ub370\ucf54\ub9b0\uc758 \uc5ed\ud560\uc5d0 \ub300\ud55c \uc5f0\uad6c\ub97c \uc9c0\uc6d0\ud558\ub294 \ubcf4\uc870\uae08\uc744 \ubc1b\uc558\uc2b5\ub2c8\ub2e4. \uadf8\ub140\ub294 Tufts University\uc758 Dr. Toole \uc5f0\uad6c\uc2e4\uc5d0\uc11c HGPS \uc5f0\uad6c\ub97c \uc2dc\uc791\ud588\uc2b5\ub2c8\ub2e4. \uc774\uc804\uc5d0 Lemire \ubc15\uc0ac\ub294 Washington University\uc5d0\uc11c Stephen M. Schwartz \ubc15\uc0ac\uc640 Thomas N. Wight \ubc15\uc0ac\uc758 \uc5f0\uad6c\uc2e4\uc5d0\uc11c \uc77c\ud558\uba74\uc11c \ud608\uad00 \ud3c9\ud65c\uadfc \uc138\ud3ec \uc720\ud615\uacfc \ud608\uad00 \ud504\ub85c\ud14c\uc624\uae00\ub9ac\uce78 versican\uc758 \uc2a4\ud50c\ub77c\uc774\uc2a4 \ubcc0\uc885\uc744 \uc5f0\uad6c\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>\ub9c8\ud06c \ub8e8\uc774\uc2a4, \ubc15\uc0ac<\/strong><br \/>\n\ud14d\uc0ac\uc2a4 \uc624\uc2a4\ud2f4 \ub300\ud559\uc758 \uc2ec\ub9ac\ud559 \uad50\uc218\uc774\uc790 \uc5f4\ub300 \uc5f0\uad6c \ubc0f \ud0d0\uc0ac \uae30\uad6c\uc758 \uc218\uc11d \ubbfc\uc871\ud559\uc790\uc785\ub2c8\ub2e4. \uadf8\ub294 \uc774 \ubd84\uc57c\uc5d0 \uc0c8\ub85c \ub4e4\uc5b4\uc654\uc73c\uba70, Cold Spring Harbor Yeast Genetics Course\uc640 Ellison Foundation Molecular Biology of Aging Course \ud3a0\ub85c\uc6b0\uc2ed\uc744 \ud1b5\ud574 \ub4e4\uc5b4\uc654\uc2b5\ub2c8\ub2e4. \uadf8\uc758 \uc5f0\uad6c\ub294 \ubd84\uc790 \uc0dd\ubb3c\ud559, \ubb38\uc81c \ud574\uacb0 \ubc0f \uc5ed\ud559\uc744 \uacb0\ud569\ud558\uc5ec \ub178\ud654\ub97c \uc0b4\ud3b4\ubd05\ub2c8\ub2e4.<\/p>\n<p><strong>\uc900 \ucf08\ub9ac \ub9ac\uc6b0, \ubc15\uc0ac<\/strong><br \/>\n\ucf54\ub12c \ub300\ud559\uad50 \ubd84\uc790\uc0dd\ubb3c\ud559 \ubc0f \uc720\uc804\ud559\uacfc \uc870\uad50\uc218. Liu \ubc15\uc0ac\uc758 \uc5f0\uad6c\uc2e4\uc740 \uc120\ucda9\ub958 C. elegans\ub97c \uc0ac\uc6a9\ud558\uc5ec \ub450 \uac00\uc9c0 \uc5f0\uad6c \ubd84\uc57c\ub97c \ud0d0\uad6c\ud569\ub2c8\ub2e4. 1) \uc911\ubc30\uc5fd\uc5d0\uc11c \uc720\ub798\ud55c \uadfc\uc721 \uc138\ud3ec\uc640 \ube44\uadfc\uc721 \uc138\ud3ec\uac00 \ubc1c\ub2ec \uc911\uc5d0 \ud2b9\uc815 \uc138\ud3ec \uc6b4\uba85\uc744 \uc120\ud0dd\ud558\ub294 \ubc29\ubc95, 2) \ub2e4\uc591\ud55c \ud575\ub9c9 \ub2e8\ubc31\uc9c8\uc774 \ubc1c\ub2ec \uc911\uc5d0 \uae30\ub2a5\ud558\ub294 \ubc29\ubc95. \ud575\ub9c9 \ud504\ub85c\uc81d\ud2b8\uc5d0 \ub300\ud55c \uc774\uc804 \uc5f0\uad6c\uc5d0\ub294 \ucd08\ud30c\ub9ac \ucd08\uae30 \ubc30\uc544 \ubc1c\ub2ec \uc911\uc5d0 \ud575\ub9c9 \ub2e8\ubc31\uc9c8 YA\uc758 \uae30\ub2a5\uc744 \ud2b9\uc131\ud654\ud558\uace0 C. elegans \ubc1c\ub2ec \uc911\uc5d0 \ub77c\ubbfc \ubc0f \ub77c\ubbfc \uad00\ub828 \ud575\ub9c9 \ub2e8\ubc31\uc9c8(LEM \ub3c4\uba54\uc778 \ub2e8\ubc31\uc9c8 Emerin \ubc0f MAN1 \ud3ec\ud568)\uc758 \uc0dd\uccb4 \ub0b4 \uae30\ub2a5\uc744 \uc124\uba85\ud558\ub294 \uac83\uc774 \ud3ec\ud568\ub429\ub2c8\ub2e4. \uadf8\ub140\ub294 \ud604\uc7ac C. elegans\ub97c \ubaa8\ub378 \uc2dc\uc2a4\ud15c\uc73c\ub85c \uc0ac\uc6a9\ud558\uc5ec \ud575\ub9c9, \ub77c\ubbfc \ubc0f \ub178\ud654 \uac04\uc758 \uad00\uacc4\ub97c \uc870\uc0ac\ud558\uace0 \uc788\uc73c\uba70 C. elegans\ub97c \uc0ac\uc6a9\ud558\uc5ec \ub2e4\uc591\ud55c \ub77c\ubbf8\ub178\ubcd1\uc758 \uc138\ud3ec \ubc0f \ubd84\uc790\uc801 \uae30\ucd08\ub97c \uc870\uc0ac\ud560 \uac00\ub2a5\uc131\uc744 \ud0d0\uad6c\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>\ubaa8\ub2c8\uce74 \ub9d0\ub78c\ud314\ub9ac \ubc15\uc0ac<\/strong><br \/>\n\uc874\uc2a4\ud649\ud0a8\uc2a4 \uc758\ub300 \uc138\ud3ec\uc0dd\ubb3c\ud559\uacfc\uc758 \ubc15\uc0ac\ud6c4 \uc5f0\uad6c\uc6d0\uc73c\ub85c, \uc218\uc794 \ubbf8\uce74\uc5d8\ub9ac\uc2a4 \ubc15\uc0ac\uc640 \ud568\uaed8 \uc77c\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>\uc218\uc794 \ubbf8\uce74\uc5d8\ub9ac\uc2a4 \ubc15\uc0ac<\/strong><br \/>\n\uc874\uc2a4\ud649\ud0a8\uc2a4 \uc758\ub300\uc758 \uc138\ud3ec\uc0dd\ubb3c\ud559 \uc0dd\ubb3c\ubb3c\ub9ac\ud559 \uad50\uc218. Michaelis \ubc15\uc0ac\uc758 \uc5f0\uad6c\ub294 Saccharomyces cerevisiae, \ud2b9\ud788 \ud6a8\ubaa8 \uad50\ubc30 \uacbd\ub85c\uc5d0 \uc9d1\uc911\ub418\uc5b4 \uc788\uc73c\uba70, \uc774\ub294 \ubaa8\ub4e0 \uc9c4\ud575 \uc138\ud3ec\uc5d0 \uacf5\ud1b5\uc801\uc778 \ub2e4\uc591\ud55c \uae30\ubcf8 \uc138\ud3ec \uc0dd\ubb3c\ud559\uc801 \uacfc\uc815\uc744 \ubd84\uc11d\ud558\ub294 \ub370 \uc774\uc0c1\uc801\uc778 \ubaa8\ub378 \uc2dc\uc2a4\ud15c\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4. \uadf8\ub140\uc758 \uc5f0\uad6c\uc2e4\uc740 \uc720\uc804\uc801, \uc0dd\ud654\ud559\uc801, \uc138\ud3ec \uc0dd\ubb3c\ud559\uc801 \uc811\uadfc \ubc29\uc2dd\uc744 \uc0ac\uc6a9\ud558\uc5ec \ub2e8\ubc31\uc9c8 \uc218\uc1a1, \ub2e8\ubc31\uc9c8\uc758 \ubc88\uc5ed \ud6c4 \ubcc0\ud615(\ud504\ub808\ub2d0\ud654, \ub2e8\ubc31\uc9c8 \ubd84\ud574 \uc808\ub2e8, \uce74\ub974\ubcf5\uc2e4 \uba54\ud2f8\ud654 \ud3ec\ud568), ER \ud488\uc9c8 \uad00\ub9ac, \uc720\ube44\ud034\ud2f4-\ud504\ub85c\ud14c\uc544\uc880 \uc2dc\uc2a4\ud15c, ABC \uc218\uc1a1\uccb4\uc5d0 \ub300\ud574 \uc54c\uc544\ubd05\ub2c8\ub2e4. \uadf8\ub140\uc758 \uc5f0\uad6c \uacb0\uacfc\ub294 \ub0ad\ud3ec\uc131 \uc12c\uc720\uc99d, Ras \uae30\ubc18 \uc554\uc758 \ud654\ud559 \uc694\ubc95 \uac1c\uc785, ABC \ub2e8\ubc31\uc9c8 \uc218\uc1a1\uccb4\ub97c \ub9e4\uac1c\ub85c \ud558\ub294 \uc885\uc591 \uc138\ud3ec\uc758 \ub2e4\uc911 \uc57d\ubb3c \ub0b4\uc131, \uadf8\ub9ac\uace0 \uac00\uc7a5 \ucd5c\uadfc\uc5d0\ub294 \uce35\uc0c1\uc138\ud3ec\uc99d\uc5d0 \uc801\uc6a9\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>\ud1b0 \ubbf8\uc2a4\ud154\ub9ac \ubc15\uc0ac<\/strong><br \/>\n\uad6d\ub9bd\uc554\uc5f0\uad6c\uc18c, NIH\uc758 \uc138\ud3ec\uc0dd\ubb3c\ud559 \uac8c\ub188 \uadf8\ub8f9 \ucc45\uc784\uc790. Misteli \ubc15\uc0ac\ub294 \uc0dd\uccb4 \ub0b4 \uc774\ubbf8\uc9d5\uacfc \uacc4\uc0b0 \ubc29\ubc95\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc0b4\uc544\uc788\ub294 \uc138\ud3ec\uc758 \ud575 \uad6c\uc870\uc640 \uac8c\ub188 \uc870\uc9c1\uc744 \uc5f0\uad6c\ud569\ub2c8\ub2e4.<\/p>\n<p><strong>\uc5d8\ub9ac\uc790\ubca0\uc2a4 G. \ub098\ubca8<\/strong><br \/>\n\uad6d\ub9bd \uc2ec\uc7a5, \ud3d0, \ud608\uc561 \uc5f0\uad6c\uc18c, NIH\uc758 \uc784\uc0c1 \uc5f0\uad6c \uacfc\ud559 \ucc45\uc784\uc790. Nabel \ubc15\uc0ac\ub294 \ud608\uad00 \uc9c8\ud658\uc758 \ubd84\uc790\uc801 \ubcd1\uc778\uacfc \uc720\uc804\uc801 \uce58\ub8cc\uc5d0 \uad00\uc2ec\uc774 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\ub140\uc758 \uc5f0\uad6c\uc2e4\uc740 \uc138\ud3ec \uc8fc\uae30 \ub2e8\ubc31\uc9c8\uc5d0 \uc758\ud55c \ud608\uad00 \ud3c9\ud65c\uadfc \uc138\ud3ec \uc99d\uc2dd\uacfc \ud608\uad00 \ub0b4 \uc5fc\uc99d\uc758 \uc870\uc808\uc744 \uc870\uc0ac\ud569\ub2c8\ub2e4. \ucd5c\uadfc\uc5d0\ub294 \uadf8\ub140\uc758 \uc5f0\uad6c\ub294 \ud608\uad00 \uc7ac\uc0dd\uc5d0\uc11c \uace8\uc218 \uc720\ub798 \uc804\uad6c \uc138\ud3ec\uc758 \uc5ed\ud560\uacfc \ud608\uad00 \uc9c8\ud658\uc778 \uc7ac\ud611\ucc29\uc758 \uc720\uc804\uccb4\ud559\uc5d0 \ub300\ud55c \uc784\uc0c1 \uc5f0\uad6c\uc5d0 \uc9d1\uc911\ub418\uc5c8\uc2b5\ub2c8\ub2e4. NHBLI\uc5d0 \ud569\ub958\ud558\uae30 \uc804\uc5d0 Nabel \ubc15\uc0ac\ub294 \ubbf8\uc2dc\uac04 \ub300\ud559\uad50\uc5d0\uc11c \uc2ec\uc7a5\ud559\uacfc\uc7a5\uc774\uc790 \uc2ec\ud608\uad00 \uc5f0\uad6c \uc13c\ud130\uc758 \ucc45\uc784\uc790\uc600\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>\ub0b8\uc2dc L \ub098\ub3c8, \ubc15\uc0ac<\/strong><br \/>\n\uad6d\ub9bd \ub178\ud654 \uc5f0\uad6c\uc18c\uc758 \uc0dd\ubb3c \uc790\uc6d0 \ubc0f \uc790\uc6d0 \uac1c\ubc1c \uc0ac\ubb34\uc18c\ub97c \uc774\ub04c\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ub178\ub839 \uc124\uce58\ub958 \uad70\uc9d1, \ub178\ub839 \uc138\ud3ec \uc740\ud589, \ub178\ub839 \uc124\uce58\ub958 \uad70\uc9d1\uc758 \uc870\uc9c1 \uc740\ud589\uc744 \ud3ec\ud568\ud558\uc5ec \ub178\ub839\ud559 \uc5f0\uad6c \ucee4\ubba4\ub2c8\ud2f0\ub97c \uc9c0\uc6d0\ud558\uae30 \uc704\ud55c \uc0c8\ub85c\uc6b4 \uc790\uc6d0\uc744 \uac1c\ubc1c\ud558\ub294 \uc5c5\ubb34\ub97c \ub2f4\ub2f9\ud569\ub2c8\ub2e4.<\/p>\n<p><strong>\uc0d0\ub9ac \ub180\ub9b0 \ubc15\uc0ac <\/strong><br \/>\n\ub274\uc695\uc8fc \uae30\ucd08\ubc1c\ub2ec\uc7a5\uc560\uc5f0\uad6c\uc18c\uc758 DNA \uc9c4\ub2e8 \uc2e4\ud5d8\uc2e4 \uc18c\uc7a5. \ub180\ub7f0 \ubc15\uc0ac\ub294 \ucde8\uc57d X \uc99d\ud6c4\uad70\uc5d0 \ub300\ud574 \uad11\ubc94\uc704\ud558\uac8c \uc5f0\uad6c\ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub140\ub294 \uc6d0\ub798 \uc138\ud3ec\uc720\uc804\ud559\uc790\ub85c \ud6c8\ub828\uc744 \ubc1b\uc558\uace0, IBR\uc5d0 \ud569\ub958\ud558\uae30 \uc804\uc5d0\ub294 \uc720\uc804\uc0c1\ub2f4\uc0ac\ub85c \uc77c\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>\uc8fc\uc138\ud398 \ub178\ubca8\ub9ac \ubc15\uc0ac<\/strong><br \/>\n\ub85c\ub9c8\uc758 \ud1a0\ub974 \ubca0\ub974\uac00\ud0c0 \ub300\ud559\uad50 \uad50\uc218. \ub178\ubca8\ub9ac \ubc15\uc0ac\uc758 \uc5f0\uad6c\uc2e4\uc740 SNP(\ub2e8\uc77c \ub274\ud074\ub808\uc624\ud0c0\uc774\ub4dc \ub2e4\ud615\uc131)\uc758 \uae30\ub2a5 \ubd84\uc11d\uacfc \ud76c\uadc0 \uc9c8\ud658\uc758 \ubd84\uc790 \uc720\uc804\ud559\uc744 \uc5f0\uad6c\ud569\ub2c8\ub2e4. \uadf8\uc758 \uc5f0\uad6c\uc2e4\uc740 \ud559\uc81c\uac04 \uc5f0\uad6c \uc811\uadfc \ubc29\uc2dd\uc744 \ucde8\ud558\uace0 \uc788\uc73c\uba70 \uc778\uac04 \uc720\uc804\ud559, \uc758\ud559 \uc720\uc804\ud559, \uc720\uc804\uccb4\ud559, \ubd84\uc790 \uc720\uc804\ud559 \ubd84\uc57c\ub97c \uacb0\ud569\ud569\ub2c8\ub2e4. \uadf8\uc758 \uc5f0\uad6c\uc2e4\uc758 \uc804\ud658 \uc5f0\uad6c \uacb0\uacfc\ub294 \ubd84\uc790 \uc9c4\ub2e8, \uc99d\uc0c1 \uc804 \ubc0f \uc608\uce21 \uc9c4\ub2e8, \uc0b0\uc804 \uc9c4\ub2e8, \uc57d\ubb3c \uc720\uc804\ud559\uc5d0 \uc801\uc6a9\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>\uc900\ucf54 \uc624\uc2dc\ub9c8, MD, PhD <\/strong><br \/>\n\uc6cc\uc2f1\ud134 \ub300\ud559\uad50 \uc758\uacfc\ub300\ud559 \ubcd1\ub9ac\ud559\uacfc \uc5f0\uad6c \uc870\uad50\uc218. \uc624\uc2dc\ub9c8 \ubc15\uc0ac\ub294 \uc624\ub7ab\ub3d9\uc548 \uc778\uac04 \ub178\ud654\uc758 \uc720\uc804\uc801 \uba54\ucee4\ub2c8\uc998\uc5d0 \uad00\uc2ec\uc744 \uac00\uc84c\uc2b5\ub2c8\ub2e4. \uadf8\ub140\ub294 \uc138\ud3ec \ub178\ud654 \ub3d9\uc548 \uc720\uc804\uc790 \ubc1c\ud604\uc758 \ubcc0\ud654\uc5d0 \uad00\ud574 \uc8fc\ub514\uc2a4 \uce84\ud53c\uc2dc \ubc15\uc0ac\uc640 \ud611\ub825\ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub7f0 \ub2e4\uc74c \uadf8\ub140\ub294 \uc5f0\ub839 \uad00\ub828 \uc720\uc804\uc801 \uc9c8\ud658, \uc54c\uce20\ud558\uc774\uba38\ubcd1 \ubc0f \ubca0\ub974\ub108 \uc99d\ud6c4\uad70\uc758 \uc704\uce58 \ubcf5\uc81c\ub97c \uc5f0\uad6c\ud588\uc73c\uba70, \uc774\ub294 \uc870\uc9c0 M. \ub9c8\ud2f4 \ubc15\uc0ac\uc640 \ud611\ub825\ud558\uc5ec \uc131\uacf5\uc801\uc73c\ub85c \ubcf5\uc81c\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc624\uc2dc\ub9c8 \ubc15\uc0ac\uc758 \uc9c4\ud589 \uc911\uc778 \ud504\ub85c\uc81d\ud2b8\uc5d0\ub294 \ubca0\ub974\ub108 \uc99d\ud6c4\uad70 \uad6d\uc81c \ub4f1\ub85d\ubd80, WRN \uc720\uc804\uc790\uc758 \uc138\ud3ec \uc0dd\ubb3c\ud559\uc801 \uc5f0\uad6c, \ub178\ud654\uc758 \uc0b0\ud654\uc801 \uc190\uc0c1 \uc774\ub860\uc5d0 \uad00\ub828\ub41c \uc720\uc804\uc790\uc758 \uc9d1\ub2e8 \uc5f0\uad6c\uac00 \ud3ec\ud568\ub429\ub2c8\ub2e4.<\/p>\n<p><strong>\ub2e4\uc708 J. \ud504\ub85c\ucf54\ud504, MD, PhD<\/strong><br \/>\nTulane University Health Sciences Center\uc758 \uc720\uc804\uc790 \uce58\ub8cc \uc13c\ud130 \uad50\uc218 \uacb8 \uc18c\uc7a5. Prockop \ubc15\uc0ac\uc758 \uc8fc\uc694 \uad00\uc2ec\uc0ac\ub294 \uace8\uc218\uc5d0\uc11c \ucd94\ucd9c\ud55c \uc131\uc778 \uc904\uae30 \uc138\ud3ec\ub97c \uc0ac\uc6a9\ud558\uc5ec \uace8\ub2e4\uacf5\uc99d, \ud30c\ud0a8\uc2a8\ubcd1, \uc54c\uce20\ud558\uc774\uba38\ubcd1\uc744 \ud3ec\ud568\ud55c \ub2e4\uc591\ud55c \uc9c8\ubcd1\uc758 \uc138\ud3ec \ubc0f \uc720\uc804\uc790 \uce58\ub8cc\uc5d0 \uc0ac\uc6a9\ud558\ub294 \uac83\uc785\ub2c8\ub2e4. \uadf8\ub294 \ub610\ud55c \ucf5c\ub77c\uac90 \uc0dd\ud569\uc131, \ucf5c\ub77c\uac90 \uc720\uc804\uc790\uc758 \uad6c\uc870 \ubc0f \uae30\ub2a5, \ubf08\uc640 \uc5f0\uace8 \uc9c8\ubcd1\uc744 \uc720\ubc1c\ud558\ub294 \uc720\uc804\uc790 \ub3cc\uc5f0\ubcc0\uc774\uc5d0 \ub300\ud55c \uc5f0\uad6c\ub97c \uc218\ud589\ud588\uc2b5\ub2c8\ub2e4. \ud604\uc7ac \uc9c1\uc704\uc5d0 \uc624\ub974\uae30 \uc804\uc5d0 Prockop \ubc15\uc0ac\ub294 MCP Hahnemann Medical School\uc758 \uc720\uc804\uc790 \uce58\ub8cc \uc13c\ud130 \uc18c\uc7a5\uc774\uc5c8\uc2b5\ub2c8\ub2e4. \uadf8\ub294 \ud540\ub780\ub4dc \uc544\uce74\ub370\ubbf8, \ubbf8\uad6d \uc758\ud559 \uc5f0\uad6c\uc18c, \ubbf8\uad6d \uacfc\ud559 \uc544\uce74\ub370\ubbf8\uc758 \uc120\ucd9c \ud68c\uc6d0\uc785\ub2c8\ub2e4.<\/p>\n<p><strong>\ud504\ub7ad\ud06c \ub85c\uc2a4\uba3c \ubc15\uc0ac <\/strong><br \/>\n\ube0c\ub77c\uc6b4 \ub300\ud559\uad50\uc758 \ubd84\uc790 \uc0dd\ubb3c\ud559, \uc138\ud3ec \uc0dd\ubb3c\ud559 \ubc0f \uc0dd\ud654\ud559(\uc5f0\uad6c) \uad50\uc218\uc774\uc790 \uba85\uc608 \uad50\ubb34\ucc98\uc7a5. Rothman \ubc15\uc0ac\ub294 PRF \uc758\ud559 \uc5f0\uad6c \uc704\uc6d0\ud68c\uc758 \ucc3d\ub9bd \uba64\ubc84\uc785\ub2c8\ub2e4. \uadf8\uc758 \uc5f0\uad6c\uc5d0\ub294 E. coli\uc758 \uc720\uc804\uc790-\ub2e8\ubc31\uc9c8 \uad00\uacc4\uc640 \uc720\uc804\uc790 \uc870\uc808\uc774 \ud3ec\ud568\ub418\uc5c8\uc73c\uba70, \uc774\uc5b4\uc11c \uc138\ud3ec \uc810\uc561 \uacf0\ud321\uc774 D. discoideum\uc758 \uc720\uc804\ud559 \ubc0f \ubc1c\ub2ec\uc5d0 \ub300\ud55c \uc5f0\uad6c\uac00 \uc774\uc5b4\uc84c\uc2b5\ub2c8\ub2e4. \ube0c\ub77c\uc6b4 \ub300\ud559\uad50\uc5d0 \uc7ac\uc9c1\ud558\ub294 \ub3d9\uc548 Rothman \ubc15\uc0ac\ub294 \ub178\ud654 \uc0dd\ubb3c\ud559 \ubd84\uc57c\uc5d0\uc11c \uc18c\uaddc\ubaa8 \uad50\uc721 \ubc0f \uc5f0\uad6c \ud504\ub85c\uadf8\ub7a8\uc744 \uac1c\ubc1c\ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub294 \ucd5c\uadfc HGPS\uc5d0 \ub300\ud55c \ud611\ub825 \uc5f0\uad6c\ub97c \uc218\ud589\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>\ud30c\uc62c\ub77c \uc2a4\uce74\ud53c\ub514 \ubc15\uc0ac<\/strong><br \/>\n\uad6d\ub9bd\uc554\uc5f0\uad6c\uc18c, NIH\uc758 \ubc15\uc0ac\ud6c4 \uc5f0\uad6c\uc6d0. Scaffidi \ubc15\uc0ac\ub294 \ub7f0\ub358 \uc624\ud508 \ub300\ud559\uad50\uc5d0\uc11c \ubc15\uc0ac \ud559\uc704\ub97c \ubc1b\uc558\uace0 \uc774\ud0c8\ub9ac\uc544 \ubc00\ub77c\ub178\uc758 Dibit, San Raffaele Scientific Institute\uc5d0\uc11c \uc77c\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>\uc170\ud37c\ub4dc H. \uc288\ub974\ub9cc, MD<\/strong><br \/>\nNIH\uc758 National Institute on Aging \uc720\uc804\ud559 \uc5f0\uad6c\uc2e4\uc758 \uc5f0\uad6c\uc6d0. \uc774\uc804\uc5d0 Schurman \ubc15\uc0ac\ub294 NIH\uc758 National Human Genome Research Institute\uc5d0\uc11c \uc5f0\uad6c\uc6d0 \ubc0f \uc8fc\uce58\uc758\ub85c \uc77c\ud558\uba74\uc11c ADA \uc720\uc804\uc790\ub97c \uc790\uac00 \uace8\uc218 \uc904\uae30 \uc138\ud3ec\ub85c \uc774\uc2dd\ud55c Adenosine Deaminase(ADA) \uacb0\ud54d \ud658\uc790\ub97c \uce58\ub8cc\ud558\ub294 \uc784\uc0c1 \ud504\ub85c\ud1a0\ucf5c\uc744 \ub2f4\ub2f9\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>\uc2a4\ud2f0\ube10 M. \uc288\uc6cc\uce20, MD, PhD<\/strong><br \/>\n\uc6cc\uc2f1\ud134 \uc2dc\uc560\ud2c0\uc5d0 \uc788\ub294 \uc6cc\uc2f1\ud134 \ub300\ud559\uad50 \uc758\ub300\uc758 \ubcd1\ub9ac\ud559 \uad50\uc218\uc774\uc790 \uc2ec\uc7a5\ud559 \ubc0f \uc0dd\uccb4\uacf5\ud559\uc758 \uacb8\uc784 \uad50\uc218\uc785\ub2c8\ub2e4. \uc288\uc6cc\uce20 \ubc15\uc0ac\uc758 \uc5f0\uad6c\uc2e4\uc740 \ud608\uad00\ubcbd \uc138\ud3ec\uc758 \uc131\uc7a5 \uc81c\uc5b4\ub97c \uc804\ubb38\uc73c\ub85c \ud569\ub2c8\ub2e4. \uadf8\ub294 &quot;\ud50c\ub77c\ud06c \ud30c\uc5f4\uc5d0 \ub300\ud55c \uc720\uc804\uccb4 \ubc0f \uc720\uc804\uc801 \uc811\uadfc&quot;\uc774\ub77c\ub294 \uc81c\ubaa9\uc758 NIH \ud504\ub85c\uadf8\ub7a8 \ud504\ub85c\uc81d\ud2b8, &quot;\uc18c\ud608\uad00\uc758 \ub0b4\ud53c \uc190\uc0c1&quot;\uc5d0 \ub300\ud55c MERIT \ubcf4\uc870\uae08, \uadf8\ub9ac\uace0 \uc5ec\ub7ec RO1 \ubcf4\uc870\uae08\uc758 \uc8fc\uc694 \uc5f0\uad6c\uc790\uc785\ub2c8\ub2e4. \uadf8\ub294 \ub610\ud55c UW\uc758 \uc2ec\ud608\uad00 \ubcd1\ub9ac\ud559 \uad50\uc721 \ud504\ub85c\uadf8\ub7a8\uc758 \ucc45\uc784\uc790\uc785\ub2c8\ub2e4. \uc288\uc6cc\uce20 \ubc15\uc0ac\ub294 \uc5ec\ub7ec \ud3b8\uc9d1 \uc704\uc6d0\ud68c\uc5d0\uc11c \ud65c\ub3d9\ud558\uba70, \uc5ec\ub7ec NHLBI \uc704\uc6d0\ud68c\uc640 \uc6cc\uc2f1\ud134 \ub300\ud559\uad50\uc758 \ub2e4\uc591\ud55c \uc704\uc6d0\ud68c \uc9c1\ucc45\uc744 \uc5ed\uc784\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>\ud3a0\ub9ac\ud398 \uc2dc\uc5d0\ub77c \ubc15\uc0ac <\/strong><br \/>\nNIA\uc758 \ub178\ud654 \uc0dd\ubb3c\ud559 \ud504\ub85c\uadf8\ub7a8\uc758 \uc138\ud3ec \uad6c\uc870 \ubc0f \uae30\ub2a5\uc5d0 \ub300\ud55c \uc138\ud3ec \uc678 \ud3ec\ud2b8\ud3f4\ub9ac\uc624 \ucc45\uc784\uc790\uc785\ub2c8\ub2e4. \uadf8\ub294 \ubca0\ub974\ub108 \uc99d\ud6c4\uad70\uc744 \ud3ec\ud568\ud55c \uac00\uc18d \ub178\ud654 \uc99d\ud6c4\uad70\uc758 \uc138\ud3ec \uae30\ubc18\uacfc \uad00\ub828\ub41c \uc751\uc6a9 \ud504\ub85c\uadf8\ub7a8\uc744 \ucc98\ub9ac\ud558\uace0 HGPS\ub97c \ub2e4\ub8e8\ub294 \ub300\ubd80\ubd84\uc758 \uc751\uc6a9 \ud504\ub85c\uadf8\ub7a8\uc744 \ucd09\uc9c4\ud569\ub2c8\ub2e4. Sierra \ubc15\uc0ac\ub294 \ub610\ud55c \ub2e8\ubc31\uc9c8 \uad6c\uc870 \ubc0f \uae30\ub2a5\uacfc \uace0\uae09 \uc5f0\uad6c \uae30\uc220 \ud3ec\ud2b8\ud3f4\ub9ac\uc624\uc5d0 \ucc38\uc5ec\ud569\ub2c8\ub2e4. \uc774\uc804\uc5d0 \uadf8\uc758 \uc5f0\uad6c\ub294 \ub178\ud654\uc5d0 \ub530\ub978 \uc2e0\ud638 \uc804\ub2ec \ubc0f \uc720\uc804\uc790 \ubc1c\ud604\uc758 \uc870\uc808 \uc7a5\uc560\uc640 \uc774 \uacfc\uc815\uc5d0\uc11c \ud504\ub85c\ud14c\uc544\uc81c\uc640 \uc778\uc0b0\uac00\uc218\ubd84\ud574\ud6a8\uc18c\uc758 \uc5ed\ud560\uc5d0 \uc9d1\uc911\ud588\uc2b5\ub2c8\ub2e4. Sierra \ubc15\uc0ac\uc758 \uacbd\ub825\uc740 \uc2a4\uc704\uc2a4, \uce60\ub808, \ubbf8\uad6d\uc5d0\uc11c \ud559\uacc4 \ubc0f \uc0b0\uc5c5\uacc4 \uc9c1\ucc45\uc744 \ub9e1\uc558\uc2b5\ub2c8\ub2e4. \uadf8\ub294 NIH \uc2dc\uc2a4\ud15c \ub0b4\ubd80\uc640 \ud574\uc678\uc5d0\uc11c \uc218\ub9ce\uc740 \uc790\ubb38 \ud328\ub110\uc5d0\uc11c \ud65c\ub3d9\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>\ucf5c\ub9b0 \uc2a4\ud29c\uc5b4\ud2b8 \ubc15\uc0ac<\/strong><br \/>\n1999\ub144 NCI\uc5d0 \ud3b8\uc785\ub41c ABL-\uae30\ucd08 \uc5f0\uad6c \ud504\ub85c\uadf8\ub7a8\uc758 \uc554 \ubc0f \ubc1c\ub2ec \uc0dd\ubb3c\ud559 \uc5f0\uad6c\uc2e4 \uc18c\uc7a5. Stewart \ubc15\uc0ac\uc758 \uc5f0\uad6c \uad00\uc2ec\uc0ac\ub294 \ud3ec\uc720\ub958 \ubc1c\ub2ec \uc720\uc804\ud559, \uadf8\ub9ac\uace0 \ubc1c\ub2ec\uacfc \uc9c8\ubcd1\uc5d0\uc11c \ud575\ub9c9\uc758 \uc5ed\ud560\uc5d0 \uc9d1\uc911\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>\ub9ac\ub178 \ud14c\uc0ac\ub864\ub85c \ubc15\uc0ac<\/strong><br \/>\n\uc218\uc11d \uc5f0\uad6c\uc6d0, \uc2e0\uacbd \ubc1c\ub2ec \uadf8\ub8f9, \ub9c8\uc6b0\uc2a4 \uc554 \uc720\uc804\ud559 \ud504\ub85c\uadf8\ub7a8, \uad6d\ub9bd\uc554\uc5f0\uad6c\uc18c \uc720\uc804\uc790 \ud0c0\uac9f\ud305 \uc2dc\uc124 \ucc45\uc784\uc790. \ud14c\uc0ac\ub864\ub85c \ubc15\uc0ac\uc758 \uad00\uc2ec\uc0ac\uc5d0\ub294 \ub9c8\uc6b0\uc2a4 \uc720\uc804\ud559 \ubc0f \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\ub9c1\uc774 \uc788\uc73c\uba70, \ud2b9\ud788 \uc2e0\uacbd \uc601\uc591 \uc778\uc790\uc5d0 \uc911\uc810\uc744 \ub461\ub2c8\ub2e4.<\/p>\n<p><strong>\ube0c\ub77c\uc774\uc5b8 \ud234 \ubc15\uc0ac<\/strong><br \/>\n\uc138\ud3ec \uc0dd\ubb3c\ud559 \ubc0f \ud574\ubd80\ud559 \uad50\uc218\uc774\uc790 \uc0ac\uc6b0\uc2a4\uce90\ub864\ub77c\uc774\ub098 \uc758\uacfc\ub300\ud559 \ud640\ub9c1\uc2a4 \uc554 \uc13c\ud130 \ud68c\uc6d0\uc785\ub2c8\ub2e4. \ud234 \ubc15\uc0ac\ub294 PRF \uc758\ud559 \uc5f0\uad6c \uc704\uc6d0\ud68c \ud68c\uc6d0\uc774\uba70, \ud130\ud504\uce20 \ub300\ud559\uc758 \uadf8\uc758 \uc5f0\uad6c\uc2e4\uc740 \ub808\uc2ac\ub9ac \uace0\ub4e0 \ubc15\uc0ac\uc758 \ud504\ub85c\uac8c\ub9ac\uc544 \uc5f0\uad6c\uc758 \ucd08\uae30 \uc5f0\uad6c\uc2e4\uc774\uc5c8\uc2b5\ub2c8\ub2e4. \ud234 \ubc15\uc0ac\uc758 \uc5f0\uad6c\uc2e4\uc740 \ucd5c\uadfc \ud788\uc54c\ub8e8\ub860\uc0b0 &quot;\uace0\uce58&quot;\uac00 HGPS \ud658\uc790\uc758 \uc12c\uc720\uc544\uc138\ud3ec\uc5d0 \uc5c6\ub2e4\ub294 \uac83\uc744 \ubc1c\uacac\ud588\uc73c\uba70, \uc138\ud3ec \uad00\ub828 \ud788\uc54c\ub8e8\ub860\uc0b0 \uc190\uc2e4\uc774 \uc138\ud3ec \ub178\ud654 \ud504\ub85c\uadf8\ub7a8\uc758 \uc77c\ubd80\uc77c \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4. \ud788\uc54c\ub8e8\ub860\uc0b0\uc740 \uc138\ud3ec\ub97c \ubb3c\ub9ac\uc801\uc73c\ub85c \ubcf4\ud638\ud558\uace0 \uc218\uc6a9\uccb4 \ub9e4\uac1c \uc138\ud3ec \ub0b4 \uc2e0\ud638 \uc804\ub2ec\uc744 \uc720\ub3c4\ud558\uc5ec \uc138\ud3ec \uc0dd\uc874\uacfc \ubc30\uc544 \ubc1c\uc0dd \ubc0f \uc131\uc778 \uc870\uc9c1 \ubcf5\uad6c \uc911 \ud615\ud0dc \ubc1c\uc0dd\uc801 \uc138\ud3ec \ud589\ub3d9\uc5d0 \uc911\uc694\ud569\ub2c8\ub2e4. \uadf8\ub294 \ubbf8\uad6d \uacfc\ud559 \uc9c4\ud765 \ud611\ud68c\uc758 \ud3a0\ub85c\uc6b0\uc774\uba70 \uc0dd\ud654\ud559 \uc800\ub110\uc758 \ud3b8\uc9d1 \uc704\uc6d0\ud68c \ud68c\uc6d0\uc785\ub2c8\ub2e4.<\/p>\n<p><strong>\uc2e4\ube44\uc544 \ube14\uccb4\ud06c \ubc15\uc0ac <\/strong><br \/>\n\uc874\uc2a4\ud649\ud0a8\uc2a4 \uc758\ub300\uc758 \uce90\uc11c\ub9b0 \uc70c\uc2a8 \ubc15\uc0ac \uc5f0\uad6c\uc2e4\uc5d0\uc11c \ubc15\uc0ac\ud6c4 \uc5f0\uad6c\uc6d0\uc73c\ub85c \uc77c\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ube14\uccb4\ud06c \ubc15\uc0ac\ub294 Lip1\uc774\ub77c\ub294 \uc0c8\ub85c\uc6b4 \ub2e8\ubc31\uc9c8\uacfc \ud575 \ub0b4\ubd80\uc758 A\ud615 \ub77c\ubbfc\uc758 \uc0c1\ud638\uc791\uc6a9\uc744 \uc5f0\uad6c\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc774\uc804\uc5d0 \uadf8\ub140\ub294 \uc624\uc2a4\ud2b8\ub9ac\uc544\uc758 \ube44\uc5d4\ub098 \ubc14\uc774\uc624\uc13c\ud130\uc5d0\uc11c \ub864\ub79c\ub4dc \ud3ec\uc774\uc2a4\ub108 \ubc15\uc0ac\uc640 \ud568\uaed8 \uc77c\ud558\uba74\uc11c \uc138\ud3ec \uc99d\uc2dd\uacfc \ud575 \uc870\ub9bd\uc5d0\uc11c \ud575 \ub0b4 \ub77c\ubbfc A\/C \uacb0\ud569 \ud30c\ud2b8\ub108\uc778 LAP2a\uc758 \uae30\ub2a5 \ubd84\uc11d\uc5d0 \uc9d1\uc911\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>\ud734\ubc84 \uc6cc\ub108 \ubc15\uc0ac <\/strong><br \/>\nNIA\uc758 \ubd80\uc18c\uc7a5. \uc6cc\ub108 \ubc15\uc0ac\ub294 \ub178\ud654 \uc0dd\ubb3c\ud559 \uc678\ubd80 \ubcf4\uc870\uae08 \ud504\ub85c\uadf8\ub7a8\uc744 \ub2f4\ub2f9\ud569\ub2c8\ub2e4. \uc6cc\ub108 \ubc15\uc0ac\uc758 \ud504\ub85c\uadf8\ub7a8\uc740 2001\ub144\uc758 \uc6d0\ub798 HGPS \uc6cc\ud06c\uc20d\uacfc \ud604\uc7ac \uc6cc\ud06c\uc20d\uc744 \ubaa8\ub450 \uacf5\ub3d9 \ud6c4\uc6d0\ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub294 2002\ub144\uacfc 2003\ub144\uc5d0 HGPS\uc5d0 \ub300\ud55c \uc5f0\uad6c \uc81c\uc548\uc744 \uc694\uccad\ud558\ub294 \ub450 \uac00\uc9c0 \ud504\ub85c\uadf8\ub7a8 \ubc1c\ud45c\ub97c \uc9c4\ud589\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>\uc564\uc11c\ub2c8 \ubc14\uc774\uc2a4 \ubc15\uc0ac <\/strong><br \/>\n\uc2dc\ub4dc\ub2c8 \ub300\ud559\uad50\uc5d0\uc11c \uc0dd\ud654\ud559 \uad50\uc218, \uae30\ubd80 \uad50\uc218\uc9c1 \ubc0f \ubd84\uc790 \uc0dd\uba85\uacf5\ud559 \ucc3d\ub9bd \uad50\uc218. Weiss \ubc15\uc0ac\ub294 \uc778\uac04 \uc5d8\ub77c\uc2a4\ud2f4\uc5d0 \uc911\uc810\uc744 \ub454 \uacb0\ud569 \uc870\uc9c1 \ub2e8\ubc31\uc9c8 \uc5f0\uad6c\ub97c \uc804\ubb38\uc73c\ub85c \ud569\ub2c8\ub2e4. \uadf8\ub294 \ubd84\uc790 \uc0dd\ubb3c\ud559\uacfc \ub2e8\ubc31\uc9c8 \uae30\ubc18 \ub3c4\uad6c\ub97c \uacb0\ud569\ud558\uc5ec HGPS\uc758 DNA \ubcc0\ud654\uc5d0 \ub530\ub978 \ubd84\uc790\uc801 \ud558\ub958 \uacb0\uacfc\ub97c \ud0d0\uad6c\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc774\uc804 \uc5f0\uad6c\uc5d0\ub294 \uc778\uac04 \ud2b8\ub85c\ud3ec\uc5d8\ub77c\uc2a4\ud2f4\uc744 \uc0dd\uc131\ud560 \uc218 \uc788\ub294 \ub300\ud615 \ud569\uc131 \uc720\uc804\uc790\uc758 \uc0dd\uc0b0\uc774 \ud3ec\ud568\ub429\ub2c8\ub2e4. Weiss \ubc15\uc0ac\ub294 \ub610\ud55c Royal Prince Alfred Hospital\uc5d0\uc11c \ubd84\uc790 \ubc0f \uc784\uc0c1 \uc720\uc804\ud559 \uba85\uc608 \ubc29\ubb38 \uc9c1\ucc45\uc744 \ub9e1\uace0 \uc788\uc73c\uba70 \uad00\ub828 \uc9c0\uc5ed \ud559\uc220 \uc9c1\ucc45\uc744 \ub9e1\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>\uce90\uc11c\ub9b0 L. \uc70c\uc2a8, \ubc15\uc0ac <\/strong><br \/>\n\uc874\uc2a4\ud649\ud0a8\uc2a4 \uc758\ub300 \uc138\ud3ec\uc0dd\ubb3c\ud559\uacfc \uad50\uc218. \uc70c\uc2a8 \ubc15\uc0ac\uc758 \uc5f0\uad6c\uc2e4\uc740 \uc5d0\uba54\ub9b0\uc5d0 \ud2b9\ud788 \uc911\uc810\uc744 \ub450\uace0 &#039;LEM-\ub3c4\uba54\uc778&#039; \ud575\ub9c9 \ub2e8\ubc31\uc9c8\uc744 \uc5f0\uad6c\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\ub140\uc758 \uc5f0\uad6c\uc2e4\uc740 \uc5d0\uba54\ub9b0\uacfc \ub77c\ubbfc \ud544\ub77c\uba58\ud2b8, BAF, \uc804\uc0ac \ubc0f \uc2a4\ud50c\ub77c\uc774\uc2f1 \uc778\uc790, &#039;\uc575\ucee4\ub9c1&#039; \ud30c\ud2b8\ub108 \ubc0f \ud575 \uc561\ud2f4 \uac04\uc758 \uc0c1\ud638 \uc791\uc6a9\uc744 \uc5f0\uad6c\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc5d0\uba54\ub9b0\uc758 \uc190\uc2e4\uc740 \uc2ec\uc7a5, \uace8\uaca9\uadfc \ubc0f \ud798\uc904\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \uc870\uc9c1 \ud2b9\uc774\uc801 \uc9c8\ud658\uc778 \uc5d0\uba38\ub9ac-\ub4dc\ub77c\uc774\ud478\uc2a4 \uadfc\uc704\ucd95\uc99d(EDMD)\uc744 \uc720\ubc1c\ud569\ub2c8\ub2e4. \uc5d0\uba54\ub9b0\uc758 \uc190\uc2e4\uc740 \ub77c\ubbfc A\uc758 \ub9ce\uc740 \uc6b0\uc131 \ubbf8\uc2a4\uc13c\uc2a4 \ub3cc\uc5f0\ubcc0\uc774\uc640 \ub9c8\ucc2c\uac00\uc9c0\ub85c \uc815\ud655\ud788 \ub3d9\uc77c\ud55c \uc9c8\ud658\uc778 EDMD\ub97c \uc720\ubc1c\ud569\ub2c8\ub2e4. \uc70c\uc2a8 \ubc15\uc0ac\uc640 \uadf8\ub140\uc758 \ub3d9\ub8cc\ub4e4\uc740 \uc5d0\uba54\ub9b0\uacfc \ub77c\ubbfc A\uac00 \ud575\uc5d0\uc11c \ub9ce\uc740 \ub2e4\ub978 \uacb0\ud569 \ud30c\ud2b8\ub108\uc758 \uc870\ub9bd \ub610\ub294 \uae30\ub2a5\uc5d0 \ud544\uc694\ud55c 3\uc911 \ubcf5\ud569\uccb4\ub97c \ud615\uc131\ud55c\ub2e4\uace0 \uac00\uc124\uc744 \uc138\uc6c1\ub2c8\ub2e4.<\/p>\n<p><strong>\ud558\uc6cc\ub4dc J. \uc6cc\uba3c, \ubc15\uc0ac<\/strong><br \/>\n\uceec\ub7fc\ube44\uc544 \ub300\ud559\uad50 \uc758\uacfc\ub300\ud559\uc758 \uc758\ud559 \ubc0f \ud574\ubd80\ud559\uacfc \uc138\ud3ec\uc0dd\ubb3c\ud559 \ubd80\uad50\uc218. Worman \ubc15\uc0ac\ub294 1987\ub144 \ub178\ubca8\uc0c1 \uc218\uc0c1\uc790 G\u00fcnter Blobel \ubc15\uc0ac\uc640 \ud568\uaed8 \ub85d\ud3a0\ub7ec \ub300\ud559\uad50\uc5d0\uc11c \ubc15\uc0ac\ud6c4 \uc5f0\uad6c\uc6d0\uc73c\ub85c \ud575\ub9c9\uacfc \ud575\ub9c9\uc5d0 \ub300\ud55c \uc5f0\uad6c\ub97c \uc2dc\uc791\ud588\uc2b5\ub2c8\ub2e4. Worman \ubc15\uc0ac\ub294 \ud575\ub9c9\uacfc \ud575\ub9c9\uc5d0 \ub300\ud55c \uc774\ud574\uc5d0 \uae30\uc5ec\ud55c \ubc14\uac00 \uc788\uc73c\uba70, \uc5ec\uae30\uc5d0\ub294 \ud575\ub9c9 \ub77c\ubbfc A\uc640 \ud575\ub9c9 \ub77c\ubbfc C\ub97c \uc778\ucf54\ub529\ud558\ub294 \uc720\uc804\uc790\uc778 LMNA\uc758 \ucd08\uae30 \uad6c\uc870\uc801 \ud2b9\uc131\ud654, \ud575\ub9c9 \ub0b4\ub9c9\uc758 \uc0c8\ub85c\uc6b4 \ub2e8\ubc31\uc9c8\uc758 \ubc1c\uacac \ubc0f cDNA \ud074\ub85c\ub2dd, \ud1b5\ud569\ub9c9\uc774 \ud575\ub9c9 \ub0b4\ub9c9\uc744 \ud45c\uc801\uc73c\ub85c \uc0bc\ub294 \ubc29\ubc95\uc5d0 \ub300\ud55c \ubaa8\ub378 \uac1c\ubc1c\uc774 \ud3ec\ud568\ub429\ub2c8\ub2e4.<\/p>\n<p><strong>\uc2a4\ud2f0\ube10 G. \uc601, MD<\/strong><br \/>\n\uce98\ub9ac\ud3ec\ub2c8\uc544 \ub300\ud559\uad50\uc758 Gladstone \uc2ec\ud608\uad00 \uc9c8\ud658 \uc5f0\uad6c\uc18c. Young \ubc15\uc0ac\uc758 \uc5f0\uad6c \uad00\uc2ec\uc0ac\ub294 \uc9c0\ub2e8\ubc31\uc9c8\uacfc \uc8fd\uc0c1\uacbd\ud654\uc99d, \ud504\ub808\ub2d0\ud654 \ub2e8\ubc31\uc9c8\uc758 \ubc88\uc5ed \ud6c4 \ucc98\ub9ac, ES \uc138\ud3ec\uc758 \uc720\uc804\uc790 \ud2b8\ub798\ud551\uc785\ub2c8\ub2e4. \uadf8\ub294 \uc758\ud559 \ubc0f \uc2ec\uc7a5\ud559\uc5d0\uc11c \ubcf4\ub4dc \uc778\uc99d\uc744 \ubc1b\uc558\uc2b5\ub2c8\ub2e4.<\/p>\n<p><strong>\ub9c8\uc774\ud074 \uc790\uc2a4\ud2b8\ub85c, BA <\/strong><br \/>\n\uc874\uc2a4\ud649\ud0a8\uc2a4 \ub300\ud559\uad50 \uc758\uacfc\ub300\ud559 \uc138\ud3ec\uc0dd\ubb3c\ud559\uacfc \uce90\uc11c\ub9b0 \uc70c\uc2a8 \ubc15\uc0ac \uc5f0\uad6c\uc2e4\uc758 \ub300\ud559\uc6d0\uc0dd.<\/p>\n<p><strong>\ub0b8\ubc84\ud2b8 A. \uc885, MD <\/strong><br \/>\n\ub274\uc695\uc8fc \uae30\ucd08\ubc1c\ub2ec\uc7a5\uc560\uc5f0\uad6c\uc18c \uc778\uac04\uc720\uc804\ud559\uacfc \ubc1c\ub2ec\uc720\uc804\ud559\uc5f0\uad6c\uc2e4\uc7a5. Zhong \ubc15\uc0ac\ub294 \uc5f0\uc57d X \uc99d\ud6c4\uad70\uacfc \ubc30\ud2bc\ubcd1\uc5d0 \ub300\ud574 \uc5f0\uad6c\ud588\uc73c\uba70, NCL(\ubc30\ud2bc \uad00\ub828 \uc9c8\ud658)\uc5d0\uc11c \ub2e8\ubc31\uc9c8 \uc0c1\ud638\uc791\uc6a9\uc744 \uc5f0\uad6c\ud558\uae30 \uc704\ud55c NIH \ubcf4\uc870\uae08\uc744 \ubc1b\uc558\uc2b5\ub2c8\ub2e4.<\/p>\n<div><a href=\"https:\/\/www.progeriaresearch.org\/assets\/files\/pdf\/V18Agenda.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">\uc77c\uc815 [109k]<\/a><\/div>\n<ul>\n<li><a href=\"https:\/\/www.progeriaresearch.org\/ko\/scientific-meetings\/\">\uc9c0\ub09c \ud68c\uc758<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Hutchinson-Gilford Workshop Bethesda, MD July 28-29, 2003 On The Heels of the Gene Discovery: PRF-NIH Joint Workshop 2003 Scientists Working Together To Develop Treatments and a Cure Less than 4 months after the Progeria gene discovery announcement, and with support from the National Institutes of Health\u2019s National Institute on Aging, Office of Rare Diseases, and [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-1902","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>2003 Workshop | The Progeria Research Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.progeriaresearch.org\/ko\/2003-hutchinson-gilford-workshop\/\" \/>\n<meta property=\"og:locale\" content=\"ko_KR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"2003 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