{"id":19201,"date":"2024-07-30T17:49:04","date_gmt":"2024-07-30T21:49:04","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?page_id=19201"},"modified":"2026-04-03T13:42:34","modified_gmt":"2026-04-03T17:42:34","slug":"prp","status":"publish","type":"page","link":"https:\/\/www.progeriaresearch.org\/ko\/prp\/","title":{"rendered":"\ud504\ub85c\uac8c\ub9ac\uc544 \uad00\ub828 \ucd9c\ud310\ubb3c"},"content":{"rendered":"

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PRF \uc5f0\uad6c \ud504\ub85c\uadf8\ub7a8 <\/span><\/strong><\/h1>\n

\uad00\ub828 \ucd9c\ud310\ubb3c<\/span><\/strong><\/h1>\n

[\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built="1" use_custom_gutter="on" gutter_width="1" specialty="on" padding_left_1="35px" padding_left_2="35px" padding_2_tablet="|||0px" padding_2_phone="|||0px" padding_2_last_edited="on|desktop" module_class_1="sidebar-secondary-nav" module_class="handprint-bg" _builder_version="4.16" background_image="https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/blue-handprint-only.png" parallax="on" parallax_method="off" inner_width="100%" inner_max_width="100%" \ucee4\uc2a4\ud140_\ud328\ub529="0|0px|54px|0px|false|false" z_index_tablet="500" border_width_top="10px" border_color_top="#8fd2ed" use_custom_width="on" width_unit="off" \ucee4\uc2a4\ud140_\ub108\ube44_\ud37c\uc13c\ud2b8="100%" global_colors_info="{}"][et_pb_column type="1_4" _builder_version="4.16" \ucee4\uc2a4\ud140_\ud328\ub529="|||" global_colors_info="{}" custom_padding__hover="|||"][et_pb_sidebar area="et_pb_widget_area_1" disabled_on="on|on|off" module_class="subpage-sidebars" _builder_version="4.24.3" animation_style="fade" z_index_tablet="500" border_width_right="5px" global_colors_info="{}"]
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\n

\ud504\ub85c\uac8c\ub9ac\uc544 \uc5f0\uad6c \uc7ac\ub2e8(PRF)\uc740 \uc804 \uc138\uacc4 \uc720\uc218 \uacfc\ud559\uc790\ub4e4\uc758 \ud504\ub85c\uac8c\ub9ac\uc544 \uc5f0\uad6c \uc99d\uc9c4\uc5d0 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \uc774 \uacfc\ud559\uc790\ub4e4\uc774 \ubc1c\ud45c\ud55c \ub9ce\uc740 \ub17c\ubb38\uc740 PRF\uc758 \ud504\ub85c\uadf8\ub7a8\uc744 \uc778\uc815\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. PRF\ub294 \ubcf4\uc870\uae08\uc744 \ud1b5\ud574 \uc790\uae08\uc744 \uc9c0\uc6d0\ud558\uace0, \uc138\ud3ec \ubc0f \uc870\uc9c1 \uc740\ud589, \uc758\ud559 \ubc0f \uc5f0\uad6c \ub370\uc774\ud130\ubca0\uc774\uc2a4, \uadf8\ub9ac\uace0 \uad6d\uc81c \ud504\ub85c\uac8c\ub9ac\uc544 \ub4f1\ub85d\uc18c\uc758 \uc790\ub8cc\uc640 \ub370\uc774\ud130\ub97c \uc81c\uacf5\ud558\uba70, \uc784\uc0c1 \uc57d\ubb3c \uc2dc\ud5d8 \uacb0\uacfc\ub97c \ubc1c\ud45c\ud558\uace0, \uc5f0\uad6c\uc790\ub4e4\uc774 \ucd5c\uc2e0 \uc5f0\uad6c \uacb0\uacfc\ub97c \ub17c\uc758\ud560 \uc218 \uc788\ub294 \uacfc\ud559 \uc6cc\ud06c\uc20d\uc744 \uac1c\ucd5c\ud568\uc73c\ub85c\uc368 \uad81\uadf9\uc801\uc73c\ub85c \ud504\ub85c\uac8c\ub9ac\uc544 \uce58\ub8cc\ubc95 \uac1c\ubc1c\ub85c \uc774\uc5b4\uc9c8 \uc5f0\uad6c\ub97c \uc9c0\uc18d\uc801\uc73c\ub85c \ucd94\uc9c4\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc544\ub798\ub294 PRF\uc758 \uc5f0\uad6c \ud504\ub85c\uadf8\ub7a8 \uc911 \ud558\ub098 \uc774\uc0c1\uc744 \uc778\uc815\ud55c \ub9ce\uc740 \ucd9c\ud310\ubb3c\uc758 \ud504\ub85c\uadf8\ub7a8\ubcc4 \ubaa9\ub85d\uc785\ub2c8\ub2e4.<\/p>\n

[\/et_pb_text][et_pb_toggle title=\u201dPRF \uc138\ud3ec \ubc0f \uc870\uc9c1 \uc740\ud589\u201d open_toggle_background_color=\u201d#f7f7f7\u2033 closed_toggle_text_color=\u201d#ffffff\u201d closed_toggle_background_color=\u201d#00b2e2\u2033 icon_color=\u201d#ffc15e\u201d open_icon_color=\u201d#ffc15e\u201d admin_label=\u201d\uc138\ud3ec \ubc0f \uc870\uc9c1 \uc740\ud589\u201d _builder_version=\u201d4.27.5\u2033 title_text_color=\u201d#00b2e2\u2033 background_color=\u201d#ffffff\u201d custom_margin=\u201d40px||40px||true|false\u201d custom_padding=\u201d|50px||50px||true\u201d animation_style=\u201dslide\u201d animation_direction=\u201dtop\u201d] animation_intensity_slide=\u201d25%\u201d link_option_url_new_window=\u201don\u201d hover_enabled=\u201d0\u2033 z_index_tablet=\u201d500\u2033 border_width_all=\u201d0px\u201d global_colors_info=\u201d{}\u201d sticky_enabled=\u201d0\u2033]<\/p>\n

\uc790\ub8cc\ub97c \ud65c\uc6a9\ud55c \ucd9c\ud310\ubb3c <\/strong><\/h4>\n

\ud504\ub85c\uac8c\ub9ac\uc544 \uc5f0\uad6c \uc7ac\ub2e8 \uc138\ud3ec \ubc0f \uc870\uc9c1 \uc740\ud589<\/strong><\/h4>\n

2026<\/strong><\/p>\n

\uc870\ub85c\uc99d \uce58\ub8cc\ub97c \uc704\ud55c 1\uc138\ub300 \ub2e8\ubc31\uc9c8 \ubd84\ud574 \ud45c\uc801 \ud0a4\uba54\ub77c(PROTAC)<\/a><\/h5>\n

Macicior-Michelena J, Telechea M, Fern\u00e1ndez D, Garc\u00eda-Mart\u00edn A, Canales \u00c1, Ortega-Guti\u00e9rrez S.\u00a0\uace0\uae09 \uacfc\ud559 (Weinh)<\/em>. 2026\ub144 3\uc6d4 23\uc77c \uc628\ub77c\uc778 \uac8c\uc7ac. doi:10.1002\/advs.202521608<\/p>\n

\ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \uc870\ub85c\uc99d \uc99d\ud6c4\uad70\uc740 \uce35\ub958 \uc804\ub2e8 \uc751\ub825\uc5d0 \ub300\ud55c \ub0b4\ud53c \uc138\ud3ec\uc758 \uc720\uc804\uc801 \ubc18\uc751\uc744 \ubcc0\ud654\uc2dc\ud0a8\ub2e4<\/a><\/h5>\n

\ucf00\ub124\ub514 CC, \uce74\ud130 JL, \ud2b8\ub7ec\uc2a4\ud0a4 GA.\u00a0\ud504\ub860\ud2b8 \ud53c\uc9c0\uc62c<\/em>. 2026;16:1599339. 2026\ub144 2\uc6d4 24\uc77c \ubc1c\ud589. doi:10.3389\/fphys.2025.1599339<\/p>\n

\ub178\ud654 \uc5b5\uc81c \u0394133p53\u03b1\ub294 \uac00\uc18d \ub178\ud654 \ubc0f \uc0ac\ub9dd\ub960\uc5d0 \ub300\uc751\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Yamada L, Liu H, von Muhlinen N, Harris CC, Horikawa I. \uc0ac\uc804 \ucd9c\ud310\ubb3c.\u00a0\ubc14\uc774\uc624\uc544\uce74\uc774\ube0c<\/em>. 2026;2025.12.31.697195. 2026\ub144 1\uc6d4 20\uc77c \ubc1c\ud589. doi:10.64898\/2025.12.31.697195<\/p>\n

\n

2025<\/strong><\/p>\n

\ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \uc870\ub85c\uc99d \uce58\ub8cc\ub97c \uc704\ud55c \uc0c8\ub85c\uc6b4 \uc138\ud3ec \ubaa8\ub378\uc5d0\uc11c \ud2b9\uc774\uc801\uc774\uace0 \ud6a8\uc728\uc801\uc778 siRNA \uc120\ud0dd<\/a><\/h5>\n

Dzianisava V, Piekarowicz K, Machowska M, Rzepecki R. \ubd84\uc790 \ud575\uc0b0<\/em>. 2025;36(4):102727. 2025\ub144 10\uc6d4 3\uc77c \ubc1c\ud589. doi:10.1016\/j.omtn.2025.102727<\/p>\n

\ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \uc870\ub85c\uc99d\uc5d0\uc11c \ube44\ud1b5\ud569\ud615 \uc720\ub3c4 \ub9cc\ub2a5 \uc904\uae30\uc138\ud3ec \uc0dd\uc131: \ub178\ud654 \uc5f0\uad6c\uc758 \ubc1c\uc804<\/a><\/h5>\n

\uce74\ub514\uc648\ub77c J, \uc0e4\ucfe0\ub974 R.\u00a0\ub178\ud654 \uc758\ud559 (\ubc00\ud134)<\/em>. 2025;8(5):493-498. 2025\ub144 9\uc6d4 22\uc77c \ubc1c\ud589. doi:10.1002\/agm2.70041<\/p>\n

\uc778\uac04 BPIFB4 \uc720\uc804\uc790\uc758 \uc7a5\uc218 \uad00\ub828 \ubcc0\uc774\ub294 \ud504\ub85c\uac8c\ub9ac\uc544 \ub9c8\uc6b0\uc2a4\uc5d0\uc11c \uc774\uc644\uae30 \uae30\ub2a5 \uc7a5\uc560\ub97c \uc608\ubc29\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Qiu Y, Cattaneo M, Maciag A, Puca AA, Madedu P.\u00a0\uc2e0\ud638 \uc804\ub2ec \ud45c\uc801<\/em>. 2025;10(1):314. 2025\ub144 9\uc6d4 29\uc77c \ucd9c\ud310. doi:10.1038\/s41392-025-02416-3<\/p>\n

\ud575\uccb4 \uc9c0\uc9c0\ub300 \uc870\uc791\uc740 \uc138\ud3ec \uc7ac\ud504\ub85c\uadf8\ub798\ubc0d \ub3d9\uc5ed\ud559\uc744 \uac15\ud654\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

\uc591 BA, Vesga-Castro C, Monteiro da Rocha A, \uc678. PNAS \ub125\uc11c\uc2a4<\/em>. 2025;4(10):pgaf307. 2025\ub144 9\uc6d4 25\uc77c \ucd9c\ud310. doi:10.1093\/pnasnexus\/pgaf307<\/p>\n

Hutchinson-Gilford Progeria \ud658\uc790\uc758 \uc804\uc0ac \ud504\ub85c\ud30c\uc77c\ub9c1\uc740 \ud504\ub85c\uac8c\ub9b0\uc758 \uc8fc\uc694 \ud45c\uc801 \uacbd\ub85c\ub97c \uc2dd\ubcc4\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Vidak S, Kim S, Misteli T. Preprint.\u00a0\ubc14\uc774\uc624\uc544\uce74\uc774\ube0c<\/em>. 2025;2025.09.18.677125. 2025\ub144 9\uc6d4 20\uc77c \ucd9c\ud310. doi:10.1101\/2025.09.18.677125<\/p>\n

\ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \uc870\ub85c\uc99d \uc99d\ud6c4\uad70\uc5d0\uc11c \uc870\uc808\ub418\uc9c0 \uc54a\uc740 miR-145 \ubc0f miR-27b: \uc9c0\ubc29 \uc0dd\uc131\uc5d0 \ub300\ud55c \uc758\ubbf8<\/a><\/h5>\n

Fenzl FQ, Lederer EM, Brumma L, \uc678. \ub178\ud654(Albany NY)<\/em>. 2025\ub144 8\uc6d4 27\uc77c \uc628\ub77c\uc778 \ucd9c\ud310. doi:10.18632\/aging.206309<\/p>\n

Hutchinson-Gilford Progeria \uc99d\ud6c4\uad70\uc5d0\uc11c SIRT1 \ubc1c\ud604 \ubc0f \ub178\ud654\uc5d0 \ub300\ud55c miR-181a\uc758 \uc601\ud5a5<\/a><\/h5>\n

Lederer EM, Fenzl FQ, Kr\u00fcger P, Schroll M, Hartinger R, Djabali K. \uc9c8\ubcd1<\/em>. 2025;13(8):245. 2025\ub144 8\uc6d4 4\uc77c \ucd9c\ud310. doi:10.3390\/diseases13080245<\/p>\n

\uc815\ub7c9\uc801 \uace0\ucc98\ub9ac\ub7c9 \uc2a4\ud06c\ub9b0\uc744 \ud1b5\ud574 p53 \ub3d9\ud615\uccb4 \u0394133p53\u03b1\ub97c \uc0c1\ud5a5 \uc870\uc808\ud558\uace0 \uc138\ud3ec \ub178\ud654\ub97c \uc5b5\uc81c\ud558\ub294 \ud654\ud569\ubb3c \uc2dd\ubcc4<\/a><\/h5>\n

Lissa D, Joruiz SM, Dranchak PK \ub4f1.\u00a0ACS Pharmacol Transl Sci<\/em>. 2025;8(7):2061-2074. 2025\ub144 6\uc6d4 20\uc77c \ucd9c\ud310. doi:10.1021\/acsptsci.5c00186<\/p>\n

\u0394133p53\u03b1\uc758 \uc57d\ub9ac\ud559\uc801 \ud65c\uc131\ud654\ub294 \uc870\ub85c\uc99d \ud658\uc790 \uc720\ub798 \uc138\ud3ec\uc758 \uc138\ud3ec \ub178\ud654\ub97c \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4.<\/a><\/h5>\n

Joruiz SM, Lissa D, Von Muhlinen N, et al. \uc0ac\uc804 \uc778\uc1c4\ubcf8.\u00a0\ubc14\uc774\uc624\uc544\uce74\uc774\ube0c<\/em>. 2025;2025.07.28.667224. 2025\ub144 8\uc6d4 2\uc77c \ucd9c\ud310. doi:10.1101\/2025.07.28.667224<\/p>\n

\ud658\uc790 \uc720\ub798 \ud53c\uc9c8 \uae30\uad00\uccb4\ub294 \ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \uc870\ub85c\uc99d \uc99d\ud6c4\uad70\uc5d0\uc11c \uc2e0\uacbd \uc804\uad6c \uc138\ud3ec\uc758 \ub178\ud654\ub97c \ubcf4\uc5ec\uc90d\ub2c8\ub2e4.<\/a><\/strong><\/h5>\n

Jeon S, Park CS, Hong J, et al.\u00a0\ub178\ud654\uc138\ud3ec<\/em>. 2025\ub144 6\uc6d4 30\uc77c \uc628\ub77c\uc778 \ucd9c\ud310.<\/p>\n

\ubc14\ub9ac\uc2dc\ud2f0\ub2d9\uacfc \ub85c\ub098\ud30c\ub2d9\uc740 \ud504\ub85c\uac8c\ub9b0\uacfc \uc5fc\uc99d\uc744 \uc2dc\ub108\uc9c0\uc801\uc73c\ub85c \ud45c\uc801\uc73c\ub85c \uc0bc\uc544 \ud504\ub85c\uac8c\ub9ac\uc544 \ub9c8\uc6b0\uc2a4\uc758 \uc218\uba85\uacfc \uac74\uac15\uc744 \uac1c\uc120\ud569\ub2c8\ub2e4.<\/a><\/strong><\/h5>\n

Kr\u00fcger P, Schroll M, Fenzl FQ, \uc678.\u00a0\uad6d\uc81c \ubd84\uc790 \uacfc\ud559 \uc800\ub110<\/em>. 2025;26(10):4849. 2025\ub144 5\uc6d4 19\uc77c \ucd9c\ud310. doi:10.3390\/ijms26104849<\/p>\n

\ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544 \uc99d\ud6c4\uad70<\/a><\/h5>\n

Gordon LB, Brown WT, Collins FS. 2003\ub144 12\uc6d4 12\uc77c [2025\ub144 3\uc6d4 13\uc77c \uc5c5\ub370\uc774\ud2b8]. In: Adam MP, Feldman J, Mirzaa GM, et al., editors. GeneReviews\u00ae [\uc778\ud130\ub137]. Seattle (WA): University of Washington, Seattle; 1993-2025.<\/p>\n

\uc6d0\ud615 RNA \ud154\ub85c\uba38\ub77c\uc81c\ub294 \uc870\ub85c\uc99d \ud658\uc790\uc758 \ub0b4\ud53c \uc138\ud3ec \ub178\ud654\ub97c \uc5ed\uc804\uc2dc\ud0a8\ub2e4<\/a><\/h5>\n

\uc9c4 W, \uce74\uc2a4\ud2f0\uc694 KD, \ub9ac H, \uc678.\u00a0\ub178\ud654\uc138\ud3ec<\/em>. 2025\ub144 2\uc6d4 23\uc77c \uc628\ub77c\uc778 \ucd9c\ud310. doi:10.1111\/acel.70021<\/p>\n

\uc544\ub370\ub2cc \uc5fc\uae30 \ud3b8\uc9d1\uc740 \ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544 \uc99d\ud6c4\uad70\uc758 \uc870\uc9c1\uacf5\ud559 \ud608\uad00 \ubaa8\ub378\uc5d0\uc11c \ubcd1\uc6d0\uc131 \ud45c\ud604\ud615\uc744 \uad6c\ucd9c\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Abutaleb NO, Gao XD, Bedapudi A, \uc678. APL\ubc14\uc774\uc624\uc5d4\uc9c0\ub2c8\uc5b4\ub9c1<\/em>. 2025;9(1):016110. 2025\ub144 2\uc6d4 26\uc77c \ucd9c\ud310. doi:10.1063\/5.0244026<\/p>\n

\n

2024<\/strong><\/p>\n

\ub178\ud654\ub41c \ud608\uad00 \ud2c8\uc0c8\ub294 Wnt \ucd95\uc758 \ubd80\uc2e0 \ubd84\ube44 \uc5b5\uc81c\ub97c \ud1b5\ud574 \uc911\uac04\uc5fd \uc904\uae30 \uc138\ud3ec\uc758 \uace8 \ud615\uc131\uc744 \ubc29\ud574\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Fleischhacker V, Milosic F, Bricelj M, \uc678. \ub178\ud654\uc138\ud3ec<\/em>. 2024;23(6):e14139. doi:10.1111\/acel.14139<\/p>\n

\ud5cc\ud305\ud134\ubcd1 \ud658\uc790\uc758 1\ucc28 \ud53c\ubd80 \uc12c\uc720\uc544\uc138\ud3ec\uc758 \ube44\uc815\uc0c1\uc801\uc778 \uc774\ub3d9 \ud2b9\uc9d5\uc740 \uc774\ubbf8\uc9c0 \uae30\ubc18 \uba38\uc2e0 \ub7ec\ub2dd \ub3c4\uad6c\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc9c8\ubcd1 \uc9c4\ud589\uc744 \ud480 \uc218 \uc788\ub294 \uc7a0\uc7ac\ub825\uc744 \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/a><\/h5>\n

Gharaba S, Shalem A, Paz O, Muchtar N, Wolf L, Weil M. \ucef4\ud4e8\ud130 \uc0dd\ubb3c\ud559 \uc758\ud559<\/em>. 2024;180:108970. doi:10.1016\/j.compbiomed.2024.108970<\/p>\n

\uc138\ud3ec \ud56d\uc0c1\uc131 \ud5a5\uc0c1: \ud45c\uc801 \uc2dd\ubb3c\uc131 \ud654\ud569\ubb3c\uc740 \uc815\uc0c1 \ubc0f \uc870\uae30 \ub178\ud654 \uc12c\uc720\uc544\uc138\ud3ec\uc5d0\uc11c \uc138\ud3ec \uac74\uac15 \uae30\ub2a5\uc744 \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4.<\/a><\/h5>\n

Hartinger R, Singh K, Leverett J, Djabali K. \uc0dd\uccb4 \ubd84\uc790<\/em>. 2024;14(10):1310. 2024\ub144 10\uc6d4 16\uc77c \ucd9c\ud310. doi:10.3390\/biom14101310<\/p>\n

NLRP3 \uc5b5\uc81c\uc81c \ub2e4\ud310\uc218\ud2b8\ub9b4\uc740 \ud504\ub85c\uac8c\ub85c\uc774\ub4dc \ub9c8\uc6b0\uc2a4\uc5d0\uc11c \ub85c\ub098\ud30c\ub2d9\uc758 \uce58\ub8cc \uc791\uc6a9\uc744 \uac1c\uc120\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Muela-Zarzuela I, Suarez-Rivero JM, Boy-Ruiz D \ub4f1. \ub178\ud654\uc138\ud3ec<\/em>. 2024;23(9):e14272. doi:10.1111\/acel.14272<\/p>\n

\ud504\ub85c\uac8c\ub9ac\uc544 \uae30\ubc18 \ud608\uad00 \ubaa8\ub378\uc740 \uc2ec\ud608\uad00 \ub178\ud654 \ubc0f \uc9c8\ubcd1\uacfc \uad00\ub828\ub41c \ub124\ud2b8\uc6cc\ud06c\ub97c \uc2dd\ubcc4\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Ngubo M, Chen Z, McDonald D, \uc678. \ub178\ud654\uc138\ud3ec<\/em>. 2024;23(7):e14150. doi:10.1111\/acel.14150<\/p>\n

\uc548\uc9c0\uc624\ud3ec\uc774\uc5d0\ud2f4-2\ub294 \ud504\ub85c\uac8c\ub9ac\uc544 \ud608\uad00\uc758 \ub0b4\ud53c\uc138\ud3ec \uae30\ub2a5 \uc7a5\uc560\ub97c \uc5ed\uc804\uc2dc\ud0a8\ub2e4<\/a><\/h5>\n

Vakili S, Izydore EK, Losert L, \uc678. \ub178\ud654\uc138\ud3ec<\/em>. 2025;24(2):e14375. doi:10.1111\/acel.14375<\/p>\n

HGPS\uac00 \uc544\ub2cc \ud658\uc790\uc758 \ud504\ub85c\uac8c\ub9b0 mRNA \ubc1c\ud604\uc740 \uc804\uc0ac\uccb4 \ub3d9\ud615\uccb4\uc758 \uad11\ubc94\uc704\ud55c \ubcc0\ud654\uc640 \uc0c1\uad00 \uad00\uacc4\uac00 \uc788\uc2b5\ub2c8\ub2e4.<\/a><\/h5>\n

\uc720 R, \uc250 H, \ub9b0 W, \ucf5c\ub9b0\uc2a4 FS, \ub9c8\uc6b4\ud2b8 SM, \uce74\uc624 K. NAR Genom Bioinform<\/em>. 2024;6(3):lqae115. 2024\ub144 8\uc6d4 29\uc77c \ucd9c\ud310. doi:10.1093\/nargab\/lqae115<\/p>\n

\ud575 \uc8fc\ubcc0\ubd80\uc5d0\uc11c \ub9ac\ubcf4\uc19c \uc0dd\ud569\uc131 \ucf54\uce6d<\/a><\/h5>\n

Zhuang Y, Guo X, Razorenova OV, Miles CE, Zhao W, Shi X. \uc0ac\uc804 \uc778\uc1c4.\u00a0\ubc14\uc774\uc624\uc544\uce74\uc774\ube0c<\/em>. 2024;2024.06.21.597078. 2024\ub144 6\uc6d4 22\uc77c \ucd9c\ud310. doi:10.1101\/2024.06.21.597078<\/p>\n

\n

2023<\/strong><\/p>\n

\ub85c\ub098\ud30c\ub2d9\uacfc \uc5d0\ubca0\ub864\ub9ac\ubb34\uc2a4\ub294 \ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544 \uc99d\ud6c4\uad70\uc758 iPSC \uc720\ub798 \uc870\uc9c1\uacf5\ud559 \ud608\uad00 \ubaa8\ub378\uc5d0\uc11c \ubcd1\ub9ac\ud559\uc744 \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4.<\/a><\/h5>\n

Abutaleb NO, Atchison L, \ucd5c L, \uadf8 \uc678 \uc5ec\ub7ec\ubd84. \uacfc\ud559 \ub300\ud45c<\/em>. 2023;13(1):5032. 2023\ub144 3\uc6d4 28\uc77c \ucd9c\ud310. doi:10.1038\/s41598-023-32035-3<\/p>\n

\ud504\ub85c\uac8c\ub9ac\uc544 \ud658\uc790 \uc720\ub798 \uc720\ub3c4 \ub2e4\ub2a5\uc131 \uc904\uae30 \uc138\ud3ec\uc5d0\uc11c \ubd84\ud654\ub41c \uc2ec\uadfc\uc138\ud3ec\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc57d\ubb3c \uc720\ubc1c \ubd80\uc815\ub9e5 \uc704\ud5d8 \ubd84\uc11d\uc744 \uc704\ud55c \ub178\ud654 \ubaa8\ub378<\/a><\/h5>\n

\ub370\uc77c\ub9acN, \uc5d8\uc2a8J, \uc640\uce74\uce20\ud0a4T. \uad6d\uc81c \ubd84\uc790 \uacfc\ud559 \uc800\ub110<\/em>. 2023;24(15):11959. 2023\ub144 7\uc6d4 26\uc77c \ucd9c\ud310. doi:10.3390\/ijms241511959<\/p>\n

\uadf8\ub810\ub9b0\uc740 \ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544 \uc99d\ud6c4\uad70\uc5d0\uc11c \uc870\uae30 \ub178\ud654\ub97c \uc9c0\uc5f0\uc2dc\ud0a8\ub2e4<\/a><\/h5>\n

Ferreira-Marques M, Carvalho A, Franco AC \ub4f1. \ub178\ud654\uc138\ud3ec<\/em>. 2023;22(12):e13983. doi:10.1111\/acel.13983<\/p>\n

\ud5cc\ud305\ud134\ubcd1 \ud658\uc790\uc758 1\ucc28 \uc12c\uc720\uc544\uc138\ud3ec\uc5d0\uc11c \uc0c8\ub85c\uc6b4 \uac1c\uc778\ud654\ub41c \ubc14\uc774\uc624\ub9c8\ucee4\ub85c\uc11c \uad50\ub780\ub41c \uc561\ud2f4 \ucea1<\/a><\/h5>\n

Gharaba S, Paz O, Feld L, \uc678. \ud504\ub7f0\ud2b8 \uc140 \ub370\ube0c \ubc14\uc774\uc62c<\/em>. 2023;11:1013721. 2023\ub144 1\uc6d4 18\uc77c \ucd9c\ud310. doi:10.3389\/fcell.2023.1013721<\/p>\n

\ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544 \uc99d\ud6c4\uad70 \ud658\uc790\uc758 \ud608\uc7a5 \ud504\ub85c\uac8c\ub9b0: \uba74\uc5ed \uac80\uc815 \uac1c\ubc1c \ubc0f \uc784\uc0c1 \ud3c9\uac00<\/a><\/h5>\n

Gordon LB, Norris W, Hamren S, \ub4f1. \uc21c\ud658<\/em>. 2023;147(23):1734-1744. doi:10.1161\/CIRCULATIONAHA.122.060002<\/p>\n

\ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544 \uc99d\ud6c4\uad70 \ubc0f \uae30\ud0c0 \uc9c0\ubc29\uc774\uc601\uc591\uc131 \uce35\uc0c1\ubcd1\uc99d\uc5d0\uc11c \ubc14\ub9ac\uc2dc\ud2f0\ub2d9\uacfc FTI \ubcf5\ud569 \uce58\ub8cc\uac00 \uc9c0\ubc29\ud615\uc131\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5<\/a><\/h5>\n

Hartinger R, Lederer EM, Schena E, Lattanzi G, Djabali K. \uc138\ud3ec<\/em>. 2023;12(10):1350. 2023\ub144 5\uc6d4 9\uc77c \ucd9c\ud310. doi:10.3390\/cells12101350<\/p>\n

\ub85c\ub098\ud30c\ub2d9\uc740 \ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \uc870\ub85c\uc99d \uc99d\ud6c4\uad70 \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc5d0\uc11c \uc2ec\ud608\uad00 \uae30\ub2a5\uacfc \uc0dd\uc874\uc728\uc744 \uac1c\uc120\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Murtada SI, Mikush N, Wang M, \uc678. \uc5d8\ub9ac\ud504<\/em>. 2023;12:e82728. 2023\ub144 3\uc6d4 17\uc77c \ucd9c\ud310. doi:10.7554\/eLife.82728<\/p>\n

\ud30c\ub124\uc2e4 \uc804\uc774\ud6a8\uc18c \uc5b5\uc81c\uc81c(FTI)\uc778 \ub85c\ub098\ud30c\ub2d9\uc740 \uc870\ub85c\uc99d \uc7a5\uc560 MAD-B \ud658\uc790\uc758 ZMPSTE24 \uacb0\ud54d \uc12c\uc720\uc544\uc138\ud3ec\uc5d0\uc11c \ud575 \ud615\ud0dc\ub97c \uac1c\uc120\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Odinammadu KO, Shilagardi K, Tuminelli K, DP \ud310\uc0ac, Gordon LB, Michaelis S. \ud575<\/em>. 2023;14(1):2288476. doi:10.1080\/19491034.2023.2288476<\/p>\n

Hutchinson-Gilford \ud504\ub85c\uac8c\ub9ac\uc544 \ud658\uc790 \uc720\ub798 \uc2ec\uadfc\uc138\ud3ec \ubaa8\ub378 LMNA \uc720\uc804\uc790 \ubcc0\ud615 \ubcf4\uc720 c.1824 C > T<\/a><\/h5>\n

\ud398\ub784\ub808\uc2a4 S, \uc2dc\uac00\ub9c8\ub2c8 V, \ub77c\uc790\uc2f1 S, Czirok A, \ub77c\uc790\uc2f1 J. \uc138\ud3ec \uc870\uc9c1 \uc5f0\uad6c<\/em>. 2023;394(1):189-207. doi:10.1007\/s00441-023-03813-2<\/p>\n

\uc5f0\ub300\uae30\uc801 \ubc0f \ubcd1\ub9ac\uc801 \ub178\ud654 \uc911 \uc2ec\uc7a5 \uc138\ud3ec\uc678 \uae30\uc9c8 \ud504\ub85c\ud14c\uc634\uc758 \ub9ac\ubaa8\ub378\ub9c1<\/a><\/h5>\n

Santinha D, Vila\u00e7a A, Estronca L, \uc678. \ubab0 \uc140 \ud504\ub85c\ud14c\uc624\ubbf9\uc2a4<\/em>. 2024;23(1):100706. doi:10.1016\/j.mcpro.2023.100706<\/p>\n

\uc870\uae30 \ub178\ud654\uc5d0 \ub530\ub978 \ub0b4\ud575\ub9c9 \ub2e8\ubc31\uc9c8 SUN2\ub97c \ud1b5\ud55c \ub0b4\uc9c8\ub9dd \uc2a4\ud2b8\ub808\uc2a4 \ud65c\uc131\ud654<\/a><\/h5>\n

Vidak S, Serebryannyy LA, Pegoraro G, Misteli T. \uc140 \ub300\ud45c<\/em>. 2023;42(5):112534. doi:10.1016\/j.celrep.2023.112534<\/p>\n

\ub3c5\ud2b9\ud55c \ud504\ub85c\uac8c\ub9b0 C-\ub9d0\ub2e8 \ud3a9\ud0c0\uc774\ub4dc\ub294 BUBR1\uc744 \uad6c\ucd9c\ud558\uc5ec \ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544 \uc99d\ud6c4\uad70 \ud45c\ud604\ud615\uc744 \uac1c\uc120\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Zhang N, Hu Q, Sui T, et al. [\uac8c\uc2dc\ub41c \uc218\uc815 \uc0ac\ud56d\uc740 Nat Aging. 2023 Jun;3(6):752\uc5d0 \ub098\ud0c0\ub0a9\ub2c8\ub2e4. doi: 10.1038\/s43587-023-00427-9].\u00a0\uc790\uc5f0 \ub178\ud654<\/em>. 2023;3(2):185-201. doi:10.1038\/s43587-023-00361-w<\/p>\n

Senotherapeutic \ud3a9\ud0c0\uc774\ub4dc \uce58\ub8cc\ub294 \uc778\uac04 \ud53c\ubd80 \ubaa8\ub378\uc5d0\uc11c \uc0dd\ubb3c\ud559\uc801 \uc5f0\ub839 \ubc0f \ub178\ud654 \ubd80\ub2f4\uc744 \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4.<\/a><\/h5>\n

Zonari A, Brace LE, Al-Katib K, et al. [\uac8c\uc2dc\ub41c \uc218\uc815 \uc0ac\ud56d\uc740 NPJ Aging. 2024 Feb 15;10(1):14\uc5d0 \ub098\ud0c0\ub0a9\ub2c8\ub2e4. doi: 10.1038\/s41514-024-00140-w].\u00a0NPJ \ub178\ud654<\/em>. 2023;9(1):10. 2023\ub144 5\uc6d4 22\uc77c \ucd9c\ud310. doi:10.1038\/s41514-023-00109-1<\/p>\n

\n

2022<\/strong><\/p>\n

\uc9c8\ub7c9 \ubd84\uc11d\ubc95\uc744 \uc774\uc6a9\ud55c Hutchinson-Gilford Progeria \ud658\uc790 \uc138\ud3ec\uc5d0\uc11c Farnesylated Progerin\uc758 \uc815\ub7c9\ud654<\/a><\/h5>\n

Camafeita E, Jorge I, Rivera-Torres J, Andr\u00e9s V, V\u00e1zquez J. \uad6d\uc81c \ubd84\uc790 \uacfc\ud559 \uc800\ub110<\/em>. 2022;23(19):11733. 2022\ub144 10\uc6d4 3\uc77c \ucd9c\ud310. doi:10.3390\/ijms231911733<\/p>\n

SerpinE1\uc740 Hutchinson-Gilford \uc870\ub85c\uc99d \uc99d\ud6c4\uad70\uc5d0\uc11c \uc138\ud3ec \uc790\uc728 \ubcd1\uc6d0\uc131 \uc2e0\ud638 \uc804\ub2ec\uc744 \uc8fc\ub3c4\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Catarinella G, Nicoletti C, Bracaglia A, \uc678. \uc138\ud3ec\uc0ac\uba78\uc7a5\uc560<\/em>. 2022;13(8):737. 2022\ub144 8\uc6d4 26\uc77c \ucd9c\ud310. doi:10.1038\/s41419-022-05168-y<\/p>\n

Hutchinson-Gilford \uc870\ub85c\uc99d \uc99d\ud6c4\uad70\uc5d0\uc11c\ub294 \ud074\ub860\uc131 \uc870\ud608\uc774 \ud754\ud558\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4.<\/a><\/h5>\n

D\u00edez-D\u00edez M, Amor\u00f3s-P\u00e9rez M, de la Barrera J, \uc678.\u00a0\ub178\uacfc\ud559<\/em>. 2023;45(2):1231-1236. doi:10.1007\/s11357-022-00607-2<\/p>\n

MG132\ub294 HGPS \uc720\uc0ac \ud658\uc790\uc758 \uc138\ud3ec\uc5d0\uc11c \ud504\ub85c\uac8c\ub9b0 \ud074\ub9ac\uc5b4\ub7f0\uc2a4\ub97c \uc720\ub3c4\ud558\uace0 \uc9c8\ubcd1 \ud45c\ud604\ud615\uc744 \uac1c\uc120\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

\ud558\ub974\ud638\ub9ac K, \uce74\uc6b0 P, \ucf00\uc774\uc2dc F, \uc678. \uc138\ud3ec<\/em>. 2022;11(4):610. 2022\ub144 2\uc6d4 10\uc77c \ucd9c\ud310. doi:10.3390\/cells11040610<\/p>\n

\ud56d-hsa-miR-59\ub294 \uc950\uc758 Hutchinson-Gilford \ud504\ub85c\uac8c\ub9ac\uc544 \uc99d\ud6c4\uad70\uacfc \uad00\ub828\ub41c \uc870\uae30 \ub178\ud654\ub97c \uc644\ud654\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Hu Q, Zhang N, Sui T \ub4f1 \uc5e0\ubcf4J<\/em>. 2023;42(1):e110937. doi:10.15252\/embj.2022110937<\/p>\n

\ub77c\ubbfc\uacfc \ud575 \ud615\ud0dc\uc758 \uacb0\ud569\ub41c \ubcc0\ud654\ub294 \uc885\uc591 \uad00\ub828 \uc778\uc790 AKTIP\uc758 \uad6d\uc18c\ud654\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce69\ub2c8\ub2e4.<\/a><\/h5>\n

\ub77c \ud1a0\ub808 M, Merigliano C, Maccaroni K, \uc678. J Exp Clin Cancer Res<\/em>. 2022;41(1):273. 2022\ub144 9\uc6d4 13\uc77c \ucd9c\ud310. doi:10.1186\/s13046-022-02480-5<\/p>\n

hTERT \ubd88\uba78\ud654 Hutchinson-Gilford Progeria \uc12c\uc720\uc544\uc138\ud3ec \uacc4\ud1b5\uc758 \ud655\ub9bd \ubc0f \ud2b9\uc131\ud654<\/a><\/h5>\n

\ub9b0 H, \uba58\uc26c J, \ud558\uc288\ucf00 M, \uc678.\u00a0\uc138\ud3ec<\/em>. 2022;11(18):2784. 2022\ub144 9\uc6d4 6\uc77c \ucd9c\ud310. doi:10.3390\/cells11182784<\/p>\n

\uc190\uc0c1\ub41c LEF1 \ud65c\uc131\ud654\ub294 Hutchinson-Gilford Progeria \uc99d\ud6c4\uad70\uc5d0\uc11c iPSC \uc720\ub798 \uac01\uc9c8\uc138\ud3ec \ubd84\ud654\ub97c \uac00\uc18d\ud654\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

\ub9c8\uc624 X, Xiong ZM, Xue H, \uc678.\u00a0\uad6d\uc81c \ubd84\uc790 \uacfc\ud559 \uc800\ub110<\/em>. 2022;23(10):5499. 2022\ub144 5\uc6d4 14\uc77c \ucd9c\ud310. doi:10.3390\/ijms23105499<\/p>\n

\ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544 \uc99d\ud6c4\uad70 \ud658\uc790\uc758 \uc720\ub3c4 \ub2e4\ub2a5\uc131 \uc904\uae30 \uc138\ud3ec\ub97c \uc774\uc6a9\ud55c \uc870\uae30 \uc2ec\uc7a5 \ub178\ud654 \ubaa8\ub378\ub9c1<\/a><\/h5>\n

Monnerat G, Kasai-Brunswick TH, Asensi KD, \uc678.\u00a0\ud504\ub860\ud2b8 \ud53c\uc9c0\uc62c<\/em>. 2022;13:1007418. 2022\ub144 11\uc6d4 23\uc77c \ucd9c\ud310. doi:10.3389\/fphys.2022.1007418<\/p>\n

\uac00\uc6b0\uc2a4 \uace1\ub960\uc740 \ud575\ub9c9\uc744 \ud76c\uc11d\ud558\uc5ec \ud2b9\ud788 \ub192\uc740 \ubcc0\ud615\ub960 \uc18d\ub3c4\uc5d0\uc11c \ud575 \ud30c\uc5f4\uc744 \ucd09\uc9c4\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Pfeifer CR, Tobin MP, Cho S, \ub4f1. \ud575<\/em>. 2022;13(1):129-143. doi:10.1080\/19491034.2022.2045726<\/p>\n

Hutchinson-Gilford Progeria \uc99d\ud6c4\uad70 \uc12c\uc720\uc544\uc138\ud3ec\uc758 \uc804\uc0ac \ud504\ub85c\ud30c\uc77c\ub9c1\uc740 \uc5f0\uace8\ub0b4 \uace8\ud654\uc758 \ucd08\uae30 \uc0ac\uac74\uacfc \uad00\ub828\ub41c \ubd84\ud654\uc5d0 \ub300\ud55c \uc911\uac04\uc5fd \uc904\uae30 \uc138\ud3ec \uacb0\uc190\uc744 \ubcf4\uc5ec\uc90d\ub2c8\ub2e4.<\/a><\/h5>\n

\uc0b0 \ub9c8\ud2f4 R, \ub2e4\uc2a4 P, \uc0cc\ub354\uc2a4 JT, \ud790 AM, \ub9e5\ucf54\ub4dc RP. \uc5d8\ub9ac\ud504<\/em>. 2022;11:e81290. 2022\ub144 12\uc6d4 29\uc77c \ucd9c\ud310. doi:10.7554\/eLife.81290<\/p>\n

MnTBAP \ubc0f Baricitinib \uce58\ub8cc\uac00 Hutchinson-Gilford Progeria \uc12c\uc720\uc544\uc138\ud3ec\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5<\/a><\/h5>\n

\ubca4\uc2a4 E, \uc544\ub180\ub4dc R, \uc790\ubc1c\ub9ac K. \uc81c\uc57d(\ubc14\uc824)<\/em>. 2022;15(8):945. 2022\ub144 7\uc6d4 29\uc77c \ucd9c\ud310. doi:10.3390\/ph15080945<\/p>\n

\uc9c1\uc811 \ud558\uc774\ube0c\ub9ac\ub514\uc81c\uc774\uc158 \uac8c\ub188 \uc774\ubbf8\uc9d5\uc5d0\uc11c \ub2e8\uc77c \ub274\ud074\ub808\uc624\ud2f0\ub4dc \uac10\ub3c4 \ub2ec\uc131<\/a><\/h5>\n

\uc655 Y, \ucf54\ud2c0 WT, \uc655 H, \uc678. \uad6d\ubbfc \uacf5\ub3d9\uccb4<\/em>. 2022;13(1):7776. 2022\ub144 12\uc6d4 15\uc77c \ucd9c\ud310. doi:10.1038\/s41467-022-35476-y<\/p>\n

\uc870\ub85c\uc99d\uc758 \ud608\uad00 \ub178\ud654: \ub0b4\ud53c \uae30\ub2a5 \uc7a5\uc560\uc758 \uc5ed\ud560<\/a><\/h5>\n

Xu Q, Mojiri A, Boulahouache L, Morales E, Walther BK, Cooke JP. \uc870\ub85c\uc99d \ud658\uc790\uc758 \ud608\uad00 \ub178\ud654: \ub0b4\ud53c \uae30\ub2a5 \uc7a5\uc560\uc758 \uc5ed\ud560.\u00a0\uc720\uc5b4 \ud558\ud2b8 J \uc624\ud508<\/em>. 2022;2(4):oeac047. 2022\ub144 7\uc6d4 28\uc77c \ucd9c\ud310. doi:10.1093\/ehjopen\/oeac047<\/strong><\/p>\n

\n

2021<\/strong><\/p>\n

JAK-STAT \uc5b5\uc81c\uc81c\uc778 \ubc14\ub9ac\uc2dc\ud2f0\ub2d9\uc740 \ud504\ub85c\uac8c\ub9ac\uc544 \uc138\ud3ec\uc5d0\uc11c \ud30c\ub124\uc2e4\ud2b8\ub79c\uc2a4\ud37c\ub77c\uc81c \uc5b5\uc81c\uc81c \ub85c\ub098\ud30c\ub2d9\uc758 \uc138\ud3ec \ub3c5\uc131\uc744 \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4.<\/a><\/h5>\n

\uc544\ub180\ub4dc R, Vehns E, Randl H, Djabali K. \uad6d\uc81c \ubd84\uc790 \uacfc\ud559 \uc800\ub110<\/em>. 2021;22(14):7474. 2021\ub144 7\uc6d4 12\uc77c \ucd9c\ud310. doi:10.3390\/ijms22147474<\/p>\n

\ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544 \uc99d\ud6c4\uad70\uc5d0 \ub300\ud55c \ud45c\uc801\ud615 \uc548\ud2f0\uc13c\uc2a4 \uce58\ub8cc \uc811\uadfc\ubc95<\/a><\/h5>\n

Erdos MR, Cabral WA, Tavarez UL \ub4f1. \ub0b4\ucd94\ub7f4 \uba54\ub4dc<\/em>. 2021;27(3):536-545. doi:10.1038\/s41591-021-01274-0<\/p>\n

\uc0c1 \ubd84\ub9ac\ub97c \ud1b5\ud55c \ub2e4\uc131\ubd84 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ud575\uc18c\uccb4\uc758 \uc790\uac00 \uc870\ub9bd<\/a><\/h5>\n

Feric M, Demarest TG, Tian J, Croteau DL, Bohr VA, Misteli T. \uc5e0\ubcf4J<\/em>. 2021;40(6):e107165. doi:10.15252\/embj.2020107165<\/p>\n

\ub0b4\ud53c\uc138\ud3ec NOS\uc758 \ud558\ud5a5 \uc870\uc808\uc744 \ud1b5\ud55c Hutchinson-Gilford \uc870\ub85c\uc99d\uc758 \ud608\uad00\uc2e0\uc0dd \ubd88\ub2a5 \uba54\ucee4\ub2c8\uc998<\/a><\/h5>\n

Gete YG, Koblan LW, Mao X \ub4f1 \ub178\ud654\uc138\ud3ec<\/em>. 2021;20(7):e13388. doi:10.1111\/acel.13388<\/p>\n

NLRP3 \uc778\ud50c\ub77c\ub9c8\uc880 \uc5b5\uc81c\ub85c \ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544 \ub3d9\ubb3c \uc950 \ubaa8\ub378\uc5d0\uc11c \uc218\uba85\uc774 \ud5a5\uc0c1\ub428<\/a><\/h5>\n

Gonz\u00e1lez-Dominguez A, Monta\u00f1ez R, Castej\u00f3n-Vega B \ub4f1.\u00a0\uc5e0\ubcf4 \ubab0 \uba54\ub4dc<\/em>. 2021;13(10):e14012. doi:10.15252\/emm.202114012<\/p>\n

\ucd5c\uc801\ud654\ub41c \ud504\ub85c\uac8c\ub9b0-\ub77c\ubbfc A \uacb0\ud569 \uc5b5\uc81c\uc81c\uc778 \ud504\ub85c\uac8c\ub9ac\ub2cc\uc740 \ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544 \uc99d\ud6c4\uad70\uc758 \uc870\uae30 \ub178\ud654 \ud45c\ud604\ud615\uc744 \uac1c\uc120\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Kang SM, Yoon MH, Ahn J, et al. [\uac8c\uc2dc\ub41c \uc218\uc815 \uc0ac\ud56d\uc740 Commun Biol. 2021 Mar 2;4(1):297. doi: 10.1038\/s42003-021-01843-6\uc5d0 \ub098\ud0c0\ub0a9\ub2c8\ub2e4.].\u00a0\ucee4\uba3c \ubc14\uc774\uc62c<\/em>. 2021;4(1):5. 2021\ub144 1\uc6d4 4\uc77c \ucd9c\ud310. doi:10.1038\/s42003-020-01540-w<\/p>\n

\uc0dd\uccb4 \ub0b4 \uc5fc\uae30 \ud3b8\uc9d1\uc73c\ub85c \uc950\uc758 \ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544 \uc99d\ud6c4\uad70\uc744 \uad6c\uc81c\ud558\ub2e4<\/a><\/h5>\n

\ucf54\ube14\ub780 LW, \uc5d0\ub974\ub418\uc2dc MR, \uc70c\uc2a8 C, et al. \uc790\uc5f0<\/em>. 2021;589(7843):608-614. doi:10.1038\/s41586-020-03086-7<\/p>\n

\ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544 \uc99d\ud6c4\uad70\uc5d0 \ub300\ud55c \uc774\uc18c\ud504\ub808\ub2d0\uc2dc\uc2a4\ud14c\uc778 \uce74\ub974\ubcf5\uc2e4\uba54\ud2f8\ud2b8\ub79c\uc2a4\ud37c\ub77c\uc81c \uae30\ubc18 \uce58\ub8cc\ubc95<\/a><\/h5>\n

Marcos-Ramiro B, Gil-Ord\u00f3\u00f1ez A, Mar\u00edn-Ramos NI, \uc678. ACS \uc13c\ud2b8 \uc0ac\uc774\uc5b8\uc2a4<\/em>. 2021;7(8):1300-1310. doi:10.1021\/acscentsci.0c01698<\/p>\n

\ud154\ub85c\uba38\ub77c\uc81c \uce58\ub8cc\ub294 \ud608\uad00 \ub178\ud654\ub97c \uc5ed\uc804\uc2dc\ud0a4\uace0 \ud504\ub85c\uac8c\ub9ac\uc544 \ub9c8\uc6b0\uc2a4\uc758 \uc218\uba85\uc744 \uc5f0\uc7a5\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

\ubaa8\uc9c0\ub9ac A, \ubc1c\ud130 BK, \uc7a5 C, \ub4f1 \uc720\ub85c \ud558\ud2b8 J<\/em>. 2021;42(42):4352-4369. doi:10.1093\/eurheartj\/ehab547<\/p>\n

\ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544 \ud53c\ubd80 \uc720\ub798 \uc804\uad6c\uc138\ud3ec\uc5d0\uc11c \uc9c0\ubc29\ud615\uc131\uc5d0 \ub300\ud55c \ud504\ub85c\uac8c\ub9b0 \ubc1c\ud604\uc758 \uc601\ud5a5<\/a><\/h5>\n

\ub098\uc9c0\ub514 F, \ud06c\ub8e8\uac70 P, \uc790\ubc1c\ub9ac K. \uc138\ud3ec<\/em>. 2021;10(7):1598. 2021\ub144 6\uc6d4 25\uc77c \ucd9c\ud310. doi:10.3390\/cells10071598<\/p>\n

\uccb4\uacc4\uc801\uc778 \uc2a4\ud06c\ub9ac\ub2dd\uc744 \ud1b5\ud574 Hutchinson-Gilford \ud504\ub85c\uac8c\ub9ac\uc544 \uc99d\ud6c4\uad70\uc5d0 \ub300\ud55c \uce58\ub8cc\uc6a9 \uc548\ud2f0\uc13c\uc2a4 \uc62c\ub9ac\uace0\ub274\ud074\ub808\uc624\ud0c0\uc774\ub4dc \uc2dd\ubcc4<\/a><\/h5>\n

Puttaraju M, \uc7ad\uc2a8 M, \ud074\ub77c\uc778 S, \uc678. [\uac8c\uc2dc\ub41c \uc218\uc815 \uc0ac\ud56d\uc740 Nat Med\uc5d0 \ub098\ud0c0\ub0a9\ub2c8\ub2e4. 2021\ub144 7\uc6d4;27(7):1309. \ub3c4\uc774: 10.1038\/s41591-021-01415-5.].\u00a0\ub0b4\ucd94\ub7f4 \uba54\ub4dc<\/em>. 2021;27(3):526-535. doi:10.1038\/s41591-021-01262-4<\/p>\n

\ubcf5\uc81c \ub178\ud654 \ub3d9\uc548 \uc815\uc0c1\uc138\ud3ec\uc640 \uc870\ub85c\uc99d \uc138\ud3ec\uc758 \uae30\ud615 \ud575\uc5d0 \ud575 \ubaa8\uacf5 \ubcf5\ud569\uccb4\uac00 \ubaa8\uc5ec \uc788\uc74c<\/a><\/h5>\n

R\u00f6hrl JM, Arnold R, Djabali K. \uc138\ud3ec<\/em>. 2021;10(1):153. 2021\ub144 1\uc6d4 14\uc77c \ucd9c\ud310. doi:10.3390\/cells10010153<\/p>\n

\n

2020<\/strong><\/p>\n

iPSC \uc720\ub798 \ub0b4\ud53c\uc138\ud3ec\ub294 Hutchinson-Gilford Progeria \uc99d\ud6c4\uad70\uc758 \uc870\uc9c1\uacf5\ud559 \ud608\uad00 \ubaa8\ub378\uc5d0\uc11c \ud608\uad00 \uae30\ub2a5\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce69\ub2c8\ub2e4.<\/a><\/h5>\n

Atchison L, Abutaleb NO, Snyder-Mounts E, \uc678. \uc904\uae30\uc138\ud3ec \ubcf4\uace0\uc11c<\/em>. 2020;14(2):325-337. doi:10.1016\/j.stemcr.2020.01.005<\/p>\n

\uc778\uac04 \ud3c9\ud65c\uadfc \ubc0f \ud608\uad00 \ub0b4\ud53c \uc138\ud3ec\uc758 \uc9c1\uc811 \uc7ac\ud504\ub85c\uadf8\ub798\ubc0d\uc740 \ub178\ud654 \ubc0f \ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544 \uc99d\ud6c4\uad70\uacfc \uad00\ub828\ub41c \uacb0\ud568\uc744 \ubcf4\uc5ec\uc90d\ub2c8\ub2e4.<\/a><\/h5>\n

Bersini S, Schulte R, Huang L, Tsai H, Hetzer MW. \uc5d8\ub9ac\ud504<\/em>. 2020;9:e54383. 2020\ub144 9\uc6d4 8\uc77c \ucd9c\ud310. doi:10.7554\/eLife.54383<\/p>\n

\ud575 \ub0b4\ubd80\uc758 \uc778\uc0b0\ud654\ub41c \ub77c\ubbfc A\/C\ub294 \ud504\ub85c\uac8c\ub9ac\uc544\uc5d0\uc11c \ube44\uc815\uc0c1\uc801\uc778 \uc804\uc0ac\uc640 \uad00\ub828\ub41c \ud65c\uc131 \uc99d\uac15\uc81c\ub97c \uacb0\ud569\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Ikegami K, Secchia S, Almakki O, Lieb JD, Moskowitz IP. \uac1c\ubc1c \uc140<\/em>. 2020;52(6):699-713.e11. doi:10.1016\/j.devcel.2020.02.011<\/p>\n

\ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \uc870\ub85c\uc99d \uc99d\ud6c4\uad70\uc5d0\uc11c \uce35\uc0c1 \uad00\ub828 \ub3c4\uba54\uc778\uc758 \ud6c4\uc131\uc720\uc804\uc801 \uc870\uc808 \ud574\uc81c<\/a><\/h5>\n

K\u00f6hler F, Bormann F, Raddatz G, \ub4f1. \uac8c\ub188\uba54\ub4dc<\/em>. 2020;12(1):46. 2020\ub144 5\uc6d4 25\uc77c \ucd9c\ud310. doi:10.1186\/s13073-020-00749-y<\/p>\n

\ud06c\ub85c\ub9c8\ud2f4\uacfc \uc138\ud3ec\uace8\uaca9 \uace0\uc815\uc740 \ud504\ub85c\uac8c\ub9b0 \ubc1c\ud604 \uc138\ud3ec\uc758 \ud575 \ud615\ud0dc\ub97c \uacb0\uc815\ud569\ub2c8\ub2e4<\/a><\/h5>\n

Lionetti MC, Bonfanti S, Fumagalli MR, \uc678. \ubc14\uc774\uc624\ud53c\uc2a4 J<\/em>. 2020;118(9):2319-2332. doi:10.1016\/j.bpj.2020.04.001<\/p>\n

\ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544 \uc99d\ud6c4\uad70\uc758 \uacfc\uc0b0\ud654\ubb3c \uc774\uc0c1 \ubc0f \uce74\ud0c8\ub77c\uc81c \uacb0\ud54d<\/a><\/h5>\n

\ub9c8\uc624 X, Bharti P, Thaivalappil A, Cao K. \ub178\ud654(Albany NY)<\/em>. 2020;12(6):5195-5208. doi:10.18632\/aging.102941<\/p>\n

SAMMY-seq\ub294 Hutchinson-Gilford Progeria \uc99d\ud6c4\uad70\uc5d0\uc11c \uc774\uc885\uc5fc\uc0c9\uc9c8\uc758 \uc870\uae30 \ubcc0\ud654\uc640 2\uac00 \uc720\uc804\uc790\uc758 \uc870\uc808 \uc774\uc0c1 \ud604\uc0c1\uc744 \ubcf4\uc5ec\uc90d\ub2c8\ub2e4.<\/a><\/h5>\n

Sebesty\u00e9n E, Marullo F, Lucini F, \uc678. \uad6d\ubbfc \uacf5\ub3d9\uccb4<\/em>. 2020;11(1):6274. 2020\ub144 12\uc6d4 8\uc77c \ucd9c\ud310. doi:10.1038\/s41467-020-20048-9<\/p>\n

PML2-\ub9e4\uac1c \uc2e4\ubaa8\uc591 \ud575\uccb4\ub294 Hutchinson-Gilford \uc870\ub85c\uc99d \uc99d\ud6c4\uad70\uc5d0\uc11c \ub2a6\uc740 \ub178\ud654\ub97c \ub098\ud0c0\ub0c4<\/a><\/h5>\n

\uc655 M, \uc655 L, \uccb8 M, \ub4f1 \ub178\ud654\uc138\ud3ec<\/em>. 2020;19(6):e13147. doi:10.1111\/acel.13147<\/p>\n

RAS \uc804\ud658 \ud6a8\uc18c 1\uc744 \ud45c\uc801\uc73c\ub85c \uc0bc\uc73c\uba74 \ub178\ud654\ub97c \uadf9\ubcf5\ud558\uace0 ZMPSTE24 \uacb0\ud54d\uc758 \ud504\ub85c\uac8c\ub9ac\uc544 \uc720\uc0ac \ud45c\ud604\ud615\uc774 \uac1c\uc120\ub429\ub2c8\ub2e4.<\/a><\/h5>\n

\uc57c\uc624 H, \uccb8 X, Kashif M, \uc678. \ub178\ud654\uc138\ud3ec<\/em>. 2020;19(8):e13200. doi:10.1111\/acel.13200<\/p>\n

\n

2019<\/strong><\/p>\n

\ubd88\uade0\ud615\ud55c \ud575-\uc138\ud3ec\uace8\uaca9 \uc5f0\uacb0\uc740 \uc870\ub85c\uc99d\uacfc \uc0dd\ub9ac\uc801 \ub178\ud654\uc5d0\uc11c \uc77c\ubc18\uc801\uc778 \uadf9\uc131 \uacb0\ud568\uc744 \uc0dd\uc131\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

\uc7a5 W, \uc655 Y, Luxton GWG, \u00d6stlund C, Worman HJ, Gundersen GG. Proc Natl Acad Sci USA<\/em>. 2019;116(9):3578-3583. doi:10.1073\/pnas.1809683116<\/p>\n

\uc778\uac04 \ud154\ub85c\uba38\ub77c\uc81c mRNA\uc758 \uc77c\uc2dc\uc801 \ub3c4\uc785\uc740 \ud504\ub85c\uac8c\ub9ac\uc544 \uc138\ud3ec\uc758 \ud2b9\uc9d5\uc744 \uac1c\uc120\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Li Y, Zhou G, Bruno IG \ub4f1. \ub178\ud654\uc138\ud3ec<\/em>. 2019;18(4):e12979. doi:10.1111\/acel.12979<\/p>\n

\ubc14\ub9ac\uc2dc\ud2f0\ub2d9\uc744 \uc774\uc6a9\ud55c JAK-STAT \uc2e0\ud638\uc804\ub2ec \uc5b5\uc81c\ub294 \ud504\ub85c\uac8c\ub9ac\uc544 \uc138\ud3ec\uc758 \uc5fc\uc99d\uc744 \uac10\uc18c\uc2dc\ud0a4\uace0 \uc138\ud3ec \ud56d\uc0c1\uc131\uc744 \uac1c\uc120\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Liu C, Arnold R, Henriques G, Djabali K. \uc138\ud3ec<\/em>. 2019;8(10):1276. 2019\ub144 10\uc6d4 18\uc77c \ucd9c\ud310. doi:10.3390\/cells8101276<\/p>\n

\uc778\uac04 \ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544 \uc99d\ud6c4\uad70\uc5d0\uc11c iPSC \uc720\ub798 \ub0b4\ud53c\uc138\ud3ec\uc758 \uae30\ub2a5 \uc7a5\uc560<\/a><\/h5>\n

\ub9c8\ud2b8\ub860 G, \ud0c4\ub2e4\ubc14\ub77c\uc580 RA, \ubc1c\ud130 BK, \uba69 S, \ubaa8\uc9c0\ub9ac A, \ucfe1 JP. \uc138\ud3ec\uc8fc\uae30<\/em>. 2019;18(19):2495-2508. doi:10.1080\/15384101.2019.1651587<\/p>\n

\ub300\uc0ac\uccb4 \ud504\ub85c\ud30c\uc77c\ub9c1\uc740 Hutchinson-Gilford \uc870\ub85c\uc99d \uc99d\ud6c4\uad70\uc73c\ub85c \uc778\ud55c \uc870\uae30 \ub178\ud654\uc758 \uc804\uc2e0\uc801 \ud2b9\uc9d5\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Monnerat G, Evaristo GPC, Evaristo JAM \ub4f1. \ub300\uc0ac\uccb4\ud559<\/em>. 2019;15(7):100. 2019\ub144 6\uc6d4 28\uc77c \ucd9c\ud310. doi:10.1007\/s11306-019-1558-6<\/p>\n

\uccb4\uc138\ud3ec \ub3cc\uc5f0\ubcc0\uc774 \ubd84\uc11d\uc740 1\ucc28 \ud53c\ubd80 \uc12c\uc720\uc544\uc138\ud3ec\uc758 \uc2dc\ud5d8\uad00 \ub0b4 \ub178\ud654 \uc911 \uc120\ud0dd\uc758 \uc9d5\ud6c4\ub97c \uc2dd\ubcc4\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Narisu N, Rothwell R, Vrta\u010dnik P, \uc678. \ub178\ud654\uc138\ud3ec<\/em>. 2019;18(6):e13010. doi:10.1111\/acel.13010<\/p>\n

\ub178\ud654\uc904\uae30\uc138\ud3ec\uc5d0\uc11c \uc138\ud3ec\uc678\uae30\uc9c8 \ud569\uc131 \ud68c\ubcf5<\/a><\/h5>\n

\ub871 N, \ubbf8\uc2a4\ud2b8\ub9ac\uc624\ud2f0\uc2a4 P, \uc655 X, \uc678. \ud30c\uc138\ube0c J<\/em>. 2019;33(10):10954-10965. doi:10.1096\/fj.201900377R<\/strong><\/p>\n

\n

2018<\/strong><\/p>\n

Smurf2\ub294 \ub77c\ubbfc A\uc640 \uc9c8\ubcd1 \uad00\ub828 \ud615\ud0dc\uc778 \ud504\ub85c\uac8c\ub9b0\uc758 \uc548\uc815\uc131\uacfc \uc790\uac00\ud3ec\uc2dd-\ub9ac\uc18c\uc880 \ud68c\uc804\uc728\uc744 \uc870\uc808\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Borroni AP, Emanuelli A, Shah PA, \uc678. \ub178\ud654\uc138\ud3ec<\/em>. 2018;17(2):e12732. doi:10.1111\/acel.12732<\/p>\n

iPS \uc720\ub798 \uc911\uac04\uc5fd \uc904\uae30 \uc138\ud3ec\uc5d0\uc11c \uc778\ud130\ud398\uc774\uc988\uc758 \ud504\ub85c\uac8c\ub9b0 \uc778\uc0b0\ud654\ub294 \ub77c\ubbfc-A,C\ubcf4\ub2e4 \ub0ae\uace0 \uae30\uacc4\uc801 \ubbfc\uac10\ub3c4\uac00 \ub0ae\uc2b5\ub2c8\ub2e4.<\/a><\/h5>\n

Cho S, Abbas A, Irianto J, \uc678. \ud575<\/em>. 2018;9(1):230-245. doi:10.1080\/19491034.2018.1460185<\/p>\n

\uc870\uace8\uc138\ud3ec \ubd84\ud654 \uc911 \uac10\uc18c\ub41c \ud45c\uc900 \u03b2-\uce74\ud14c\ub2cc \uc2e0\ud638 \uc804\ub2ec\uc740 \uc870\ub85c\uc99d \ud658\uc790\uc758 \uace8\uac10\uc18c\uc99d\uc5d0 \uae30\uc5ec\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

\ucd5c JY, \ub77c\uc774 JK, Xiong ZM, \uc678. J \ubcf8 \ub9c8\uc774\ub108 \uc5f0\uad6c<\/em>. 2018;33(11):2059-2070. doi:10.1002\/jbmr.3549<\/p>\n

\uc5d0\ubca0\ub864\ub9ac\ubb34\uc2a4\ub294 \uce35\uc0c1\ubcd1 \ud658\uc790 \uc12c\uc720\uc544\uc138\ud3ec\uc758 \uc5ec\ub7ec \uc138\ud3ec \uacb0\ud568\uc744 \uad6c\uc81c\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

DuBose AJ, Lichtenstein ST, Petrash NM, Erdos MR, Gordon LB, Collins FS. [\uac8c\uc2dc\ub41c \uc218\uc815 \uc0ac\ud56d\uc740 Proc Natl Acad Sci US A. 2018\ub144 4\uc6d4 24\uc77c;115(17):E4140\uc5d0 \ub098\ud0c0\ub0a9\ub2c8\ub2e4. doi: 10.1073\/pnas.1805694115.].\u00a0Proc Natl Acad Sci USA<\/em>. 2018;115(16):4206-4211. doi:10.1073\/pnas.1802811115<\/p>\n

\uc778\uac04 \ud53c\ubd80 \uc12c\uc720\uc544\uc138\ud3ec \uc804\uc0ac\uccb4\ub85c\ubd80\ud130 \uc5f0\ub839 \uc608\uce21<\/a><\/h5>\n

Fleischer JG, Schulte R, Tsai HH, \uc678. \uac8c\ub188\ubc14\uc774\uc62c<\/em>. 2018;19(1):221. 2018\ub144 12\uc6d4 20\uc77c \ucd9c\ud310. doi:10.1186\/s13059-018-1599-6<\/p>\n

\uc778\uc9c0\uc9c8\ubd84\ud574\ud6a8\uc18c A2 \uc218\uc6a9\uccb4\ub97c \ud45c\uc801\uc73c\ub85c \uc0bc\uc73c\uba74 \uc870\uae30 \ub178\ud654 \ud45c\ud604\ud615\uc774 \uac1c\uc120\ub429\ub2c8\ub2e4.<\/a><\/h5>\n

Griveau A, Wiel C, Le Calv\u00e9 B, \ub4f1. \ub178\ud654\uc138\ud3ec<\/em>. 2018;17(6):e12835. doi:10.1111\/acel.12835<\/p>\n

\ud53c\ubd80 \ubc0f \ud608\uc561 \uc138\ud3ec\uc758 \ud6c4\uc0dd\uc720\uc804\uc801 \uc2dc\uacc4\uac00 \ud5c8\uce5c\uc2a8 \uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544 \uc99d\ud6c4\uad70\uacfc \uccb4\uc678 \uc5f0\uad6c\uc5d0 \uc801\uc6a9\ub428<\/a><\/h5>\n

\ud638\ub974\ubc14\uc2a4 S, \uc624\uc2dc\ub9c8 J, \ub9c8\ud2f4 GM \ub4f1. \ub178\ud654(Albany NY)<\/em>. 2018;10(7):1758-1775. doi:10.18632\/aging.101508<\/p>\n

\uc138\ud3ec \ub0b4\uc7ac\uc801 \uc778\ud130\ud398\ub860 \uc720\uc0ac \ubc18\uc751\uc740 \ud504\ub85c\uac8c\ub9b0\uc73c\ub85c \uc778\ud55c \uc138\ud3ec \ub178\ud654\uc5d0 \ubcf5\uc81c \uc2a4\ud2b8\ub808\uc2a4\ub97c \uc5f0\uacb0\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Kreienkamp R, Graziano S, Coll-Bonfill N, \uc678. \uc140 \ub300\ud45c<\/em>. 2018;22(8):2006-2015. doi:10.1016\/j.celrep.2018.01.090<\/p>\n

LMNA \uc74c\uc131 \uccad\uc18c\ub144 \uc870\ub85c\uc99d \uc0ac\ub840 \ubd84\uc11d\uc740 Wiedemann-Rautenstrauch \uc720\uc0ac \uc99d\ud6c4\uad70\uc5d0\uc11c \uc774\uc911 \ub300\ub9bd\uc720\uc804\uc790 POLR3A \ub3cc\uc5f0\ubcc0\uc774\ub97c \ud655\uc778\ud558\uace0 PYCR1 \ub3cc\uc5f0\ubcc0\uc774\uc758 \ud45c\ud604\ud615 \uc2a4\ud399\ud2b8\ub7fc\uc744 \ud655\uc7a5\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Lessel D, Ozel AB, Campbell SE \ub4f1.\u00a0\ud5d8 \uc81c\ub124<\/em>. 2018;137(11-12):921-939. doi:10.1007\/s00439-018-1957-1<\/p>\n

\ud30c\ub124\uc2e4\ud654\ub41c \uce74\ub974\ubcf5\uc2dc \ub9d0\ub2e8 \ub77c\ubbfc \ud3a9\ud0c0\uc774\ub4dc\uc758 \uc790\uac00\ud3ec\uc2dd \uc81c\uac70<\/a><\/h5>\n

\ub8e8 X, \uc790\ubc1c\ub9ac K. \uc138\ud3ec<\/em>. 2018;7(4):33. 2018\ub144 4\uc6d4 23\uc77c \ucd9c\ud310. doi:10.3390\/cells7040033<\/p>\n

p53 \ub3d9\ud615\uccb4\ub294 \uc778\uac04 \uc138\ud3ec\uc758 \uc870\uae30 \ub178\ud654\ub97c \uc870\uc808\ud569\ub2c8\ub2e4<\/a><\/h5>\n

\ud3f0 Muhlinen N, Horikawa I, Alam F, \uadf8 \uc678 \uc5ec\ub7ec\ubd84. \uc628\ucf54\uc9c4<\/em>. 2018;37(18):2379-2393. doi:10.1038\/s41388-017-0101-3<\/p>\n

\n

2017<\/strong><\/p>\n

SIRPA \uc5b5\uc81c, \uace8\uc218 \uc720\ub798 \ub300\uc2dd\uc138\ud3ec\ub294 \uace0\ud615 \uc885\uc591\uc758 \ud56d\uccb4 \ud45c\uc801 \ud1f4\ud589\uc5d0\uc11c \ud33d\ucc3d, \ucd95\uc801 \ubc0f \ubd84\ud654\ub429\ub2c8\ub2e4.<\/a><\/h5>\n

Alvey CM, Spinler KR, Irianto J, \uc678. \ucee4 \ubc14\uc774\uc62c<\/em>. 2017;27(14):2065-2077.e6. doi:10.1016\/j.cub.2017.06.005<\/p>\n

\uc870\uae30 \ub178\ud654\uc5d0\uc11c\uc758 \ud575\uc18c\uccb4 \ud655\uc7a5 \ubc0f \ub2e8\ubc31\uc9c8 \ubc88\uc5ed \uc99d\uac00<\/a><\/h5>\n

\ubd80\ud750\ubc1c\ud130 A, \ud5e4\ucc98 MW. \uad6d\ubbfc \uacf5\ub3d9\uccb4<\/em>. 2017;8(1):328. 2017\ub144 8\uc6d4 30\uc77c \ucd9c\ud310. doi:10.1038\/s41467-017-00322-z<\/p>\n

\ud504\ub85c\uac8c\ub9ac\uc544 \uc12c\uc720\uc544\uc138\ud3ec \uc7ac\ud504\ub85c\uadf8\ub798\ubc0d\uc740 \uc815\uc0c1\uc801\uc778 \ud6c4\uc131\uc720\uc804\uc801 \ud48d\uacbd\uc744 \uc7ac\uc815\ub9bd\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Chen Z, Chang WY, Etheridge A \ub4f1. \ub178\ud654\uc138\ud3ec<\/em>. 2017;16(4):870-887. doi:10.1111\/acel.12621<\/p>\n

\ud30c\ub124\uc2e4\ud2b8\ub79c\uc2a4\ud37c\ub77c\uc81c \uc5b5\uc81c\uc81c\uc640 \uc124\ud3ec\ub77c\ud310\uc744 \uc774\uc6a9\ud55c \uac04\ud5d0\uc801 \uce58\ub8cc\ub294 \ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544 \uc12c\uc720\uc544\uc138\ud3ec\uc758 \uc138\ud3ec \ud56d\uc0c1\uc131\uc744 \uac1c\uc120\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

\uac00\ube0c\ub9ac\uc5d8 D, \uc0e4\ud504\ub9ac DD, \uace0\ub4e0 LB, \uc790\ubc1c\ub9ac K. \uc628\ucf54\ud0c0\uac9f<\/em>. 2017;8(39):64809-64826. 2017\ub144 7\uc6d4 18\uc77c \ucd9c\ud310. doi:10.18632\/oncotarget.19363<\/p>\n

PCNA\uc758 \ud504\ub85c\uac8c\ub9b0 \uaca9\ub9ac\ub294 \uce35\uc0c1\ubcd1 \uad00\ub828 \ud504\ub85c\uac8c\ub85c\uc774\ub4dc \uc99d\ud6c4\uad70\uc5d0\uc11c \ubcf5\uc81c \ud3ec\ud06c \ubd95\uad34\uc640 XPA\uc758 \uc798\ubabb\ub41c \uc704\uce58 \uc9c0\uc815\uc744 \ucd09\uc9c4\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

\ud790\ud2bc BA, \ub958 J, \uce74\ud2b8\ub77c\uc774\ud2b8 BM \ub4f1. \ud30c\uc138\ube0c J<\/em>. 2017;31(9):3882-3893. doi:10.1096\/fj.201700014R<\/p>\n

\uac00\uad50\ub41c \ub9e4\ud2b8\ub9ad\uc2a4 \uac15\uc131\uacfc \uac00\uc6a9\uc131 \ub808\ud2f0\ub178\uc774\ub4dc\ub294 \uc904\uae30\uc138\ud3ec \ubd84\ud654\uc758 \ud575\ub9c9 \uc870\uc808\uc5d0\uc11c \uc2dc\ub108\uc9c0 \ud6a8\uacfc\ub97c \ubc1c\ud718\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Ivanovska IL, Swift J, Spinler K, Dingal D, Cho S, Discher DE. \ubab0 \ubc14\uc774\uc62c \uc140<\/em>. 2017;28(14):2010-2022. doi:10.1091\/mbc.E17-01-0010<\/p>\n

\uc0c8\ub85c\uc6b4 PDE\u03b4 \uc0c1\ud638 \uc791\uc6a9 \ub2e8\ubc31\uc9c8 \uc2dd\ubcc4<\/a><\/h5>\n

K\u00fcchler P, Zimmermann G, Winzker M, Janning P, Waldmann H, Ziegler S. \ubc14\uc774\uc624\uc624\ub974\uadf8 \uba54\ub4dc\ucf10<\/em>. 2018;26(8):1426-1434. doi:10.1016\/j.bmc.2017.08.033<\/p>\n

\ud154\ub85c\uba38\ub77c\uc81c mRNA\ub294 \ud504\ub85c\uac8c\ub9ac\uc544 \uc138\ud3ec\uc758 \ub178\ud654\ub97c \uc5ed\uc804\uc2dc\ud0a8\ub2e4<\/a><\/h5>\n

\ub9ac Y, \uc800\uc6b0 G, \ube0c\ub8e8\ub178 IG, \ucfe1 JP. J Am Coll Cardiol<\/em>. 2017;70(6):804-805. doi:10.1016\/j.jacc.2017.06.017<\/p>\n

\uba54\ud2b8\ud3ec\ub974\ubbfc\uc740 \ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544 \uc99d\ud6c4\uad70 \ud53c\ubd80 \uc12c\uc720\uc544\uc138\ud3ec\uc758 \ub178\ud654 \uc138\ud3ec \ud45c\ud604\ud615\uc744 \uc644\ud654\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

\ubc15 SK, \uc2e0 OS. \uc5d1\uc2a4\ud53c \ub370\ub974\ub9c8\ud1a8<\/em>. 2017;26(10):889-895. doi:10.1111\/exd.13323<\/p>\n

\ud575\uc9c8 \ub77c\ubbfc\uc740 \ud504\ub85c\uac8c\ub9ac\uc544 \uc138\ud3ec\uc5d0\uc11c \ub77c\ubbf8\ub098 \uad00\ub828 \ud3f4\ub9ac\ud3a9\ud2f0\ub4dc 2\u03b1\uc758 \uc131\uc7a5 \uc870\uc808 \uae30\ub2a5\uc744 \uc815\uc758\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Vidak S, Georgiou K, Fichtinger P, Naetar N, Dechat T, Foisner R. \uc138\ud3ec\uacfc\ud559 \uc800\ub110<\/em>. 2018;131(3):jcs208462. 2018\ub144 2\uc6d4 8\uc77c \ucd9c\ud310. doi:10.1242\/jcs.208462<\/p>\n

\n

2016<\/strong><\/p>\n

\uc0c8\ub85c\uc6b4 \uccb4\uc138\ud3ec \ub3cc\uc5f0\ubcc0\uc774\ub85c \ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \uc870\ub85c\uc99d \uc99d\ud6c4\uad70\uc774 \uc788\ub294 \uc5b4\ub9b0\uc774\uc758 \ubd80\ubd84\uc801 \uad6c\uc870\uac00 \ub2ec\uc131\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/a><\/h5>\n

Bar DZ, Arlt MF, Brazier JF \ub4f1. \uc81c\uc774 \uba54\ub4dc \uc81c\ub137<\/em>. 2017;54(3):212-216. doi:10.1136\/jmedgenet-2016-104295<\/p>\n

\ud504\ub85c\uac8c\ub9b0\uc740 \ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544 \uc12c\uc720\uc544\uc138\ud3ec\uc758 \uc911\uae30 \ub3d9\uc5ed\uccb4\uc5d0\uc11c CENP-F\ub97c \uace0\uac08\uc2dc\ucf1c \uc5fc\uc0c9\uccb4 \uc720\uc9c0\ub97c \uc190\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4.<\/a><\/h5>\n

\uc544\uc774\uc26c V, \ub8e8 X, \uac00\ube0c\ub9ac\uc5d8 D, \uc790\ubc1c\ub9ac K. \uc628\ucf54\ud0c0\uac9f<\/em>. 2016;7(17):24700-24718. doi:10.18632\/oncotarget.8267<\/p>\n

\ud15c\uc2dc\ub864\ub9ac\ubb34\uc2a4\ub294 \ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544 \uc138\ud3ec \ud45c\ud604\ud615\uc744 \ubd80\ubd84\uc801\uc73c\ub85c \uad6c\ucd9c\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

\uac00\ube0c\ub9ac\uc5d8 D, \uace0\ub4e0 LB, \uc790\ubc1c\ub9ac K. \ud50c\ub85c\uc2a4 \uc6d0<\/em>. 2016;11(12):e0168988. 2016\ub144 12\uc6d4 29\uc77c \ucd9c\ud310. doi:10.1371\/journal.pone.0168988<\/p>\n

\ube44\ud0c0\ubbfc D \uc218\uc6a9\uccb4 \uc2e0\ud638 \uc804\ub2ec\uc740 Hutchinson-Gilford progeria \uc99d\ud6c4\uad70 \uc138\ud3ec \ud45c\ud604\ud615\uc744 \uac1c\uc120\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Kreienkamp R, Croke M, Neumann MA, \uc678. \uc628\ucf54\ud0c0\uac9f<\/em>. 2016;7(21):30018-30031. doi:10.18632\/oncotarget.9065<\/p>\n

NANOG\ub294 ACTIN \ud544\ub77c\uba58\ud2b8 \uc870\uc9c1\uacfc SRF \uc758\uc874 \uc720\uc804\uc790 \ubc1c\ud604\uc744 \ud68c\ubcf5\ud558\uc5ec \ub178\ud654 \uc904\uae30 \uc138\ud3ec\uc758 \uadfc\uc6d0\uc801 \ubd84\ud654 \uc7a0\uc7ac\ub825\uc744 \uc5ed\uc804\uc2dc\ud0b5\ub2c8\ub2e4.<\/a><\/h5>\n

\ubbf8\uc2a4\ud2b8\ub9ac\uc624\ud2f0\uc2a4 P, \ubc14\uc988\ud30c\uc774 VK, \uc655 X, et al. \uc904\uae30\uc138\ud3ec<\/em>. 2017;35(1):207-221. doi:10.1002\/stem.2452<\/p>\n

\ud504\ub85c\uac8c\ub9ac\uc544\uc640 \uad00\ub828\ub41c \ub77c\ubbfc A \ub3cc\uc5f0\ubcc0\uc774\uccb4\uc758 \uc601\uad6c\uc801\uc778 \ud30c\ub124\uc2e4\ud654\ub294 \uc0c1\ud638\uc791\uc6a9 \uc911 \uc138\ub9b0 22\uc5d0\uc11c\uc758 \uc778\uc0b0\ud654\ub97c \uc190\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4.<\/a><\/h5>\n

Moiseeva O, Lopes-Paciencia S, Huot G, Lessard F, Ferbeyre G. \ub178\ud654(Albany NY)<\/em>. 2016;8(2):366-381. doi:10.18632\/aging.100903<\/p>\n

\ud504\ub9ac\ub77c\ubbfc A\uc758 ZMPSTE24 \uc808\ub2e8 \ubd80\uc704\ub97c \uc5c6\uc560\ub294 \ub3cc\uc5f0\ubcc0\uc774\ub294 \uc870\ub85c\uc99d \uc7a5\uc560\ub97c \uc720\ubc1c\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

\uc655 Y, Lichter-Konecki U, Anyane-Yeboa K, \uc678. \uc138\ud3ec\uacfc\ud559 \uc800\ub110<\/em>. 2016;129(10):1975-1980. doi:10.1242\/jcs.187302<\/p>\n

2A \ud3a9\ud0c0\uc774\ub4dc \uae30\ubc18 \uc2dc\uc2a4\ud15c\uc744 \uc0ac\uc6a9\ud558\uc5ec \ub77c\ubbfc \ub2e8\ubc31\uc9c8\uc758 \ubc88\uc5ed \ud6c4 \uc0c1\ub300\uc801 \uc548\uc815\uc131\uc744 \ube44\uad50\ud558\uba74 \ud504\ub85c\uac8c\ub9b0\uc758 \uc138\ud3ec \ubd84\ud574\uc5d0 \ub300\ud55c \uc800\ud56d\uc131\uc774 \ub192\uc544\uc9d0\uc774 \ub4dc\ub7ec\ub0ac\uc2b5\ub2c8\ub2e4.<\/a><\/h5>\n

\uc6b0 D, \uc608\uc774\uce20 PA, \uc7a5 H, \uce74\uc624 K. \ud575<\/em>. 2016;7(6):585-596.<\/p>\n

doi:10.1080\/19491034.2016.1260803<\/p>\n

H3K9me3 \uc190\uc2e4\uc740 Hutchinson-Gilford Progeria \uc99d\ud6c4\uad70\uc5d0\uc11c ATM \ud65c\uc131\ud654 \ubc0f \ud788\uc2a4\ud1a4 H2AX \uc778\uc0b0\ud654 \uacb0\ud54d\uacfc \uc0c1\uad00\uad00\uacc4\uac00 \uc788\uc74c<\/a><\/h5>\n

\uc7a5 H, \uc120 L, \uc655 K, \ub4f1 \ud50c\ub85c\uc2a4 \uc6d0<\/em>. 2016;11(12):e0167454. 2016\ub144 12\uc6d4 1\uc77c \ucd9c\ud310. doi:10.1371\/journal.pone.0167454<\/strong><\/p>\n

\n

2015<\/strong><\/p>\n

\ud504\ub85c\uac8c\ub9b0 \ubc1c\ud604\uc5d0 \ub530\ub978 \ud575 \uacbd\ud654 \ubc0f \ud06c\ub85c\ub9c8\ud2f4 \uc5f0\ud654\ub294 \ud798\uc5d0 \ub300\ud55c \ud575 \ubc18\uc751\uc774 \uc57d\ud654\ub418\ub294 \uacb0\uacfc\ub97c \ucd08\ub798\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

\ubd80\uc2a4 EA, Spagnol ST, Alcoser TA, Dahl KN. \uc18c\ud504\ud2b8 \ub9e4\ud130<\/em>. 2015;11(32):6412-6418. doi:10.1039\/c5sm00521c<\/p>\n

\ub77c\ubbfc A\ub294 \ub0b4\uc778\uc131 SIRT6 \ud65c\uc131\uc81c\uc774\uba70 SIRT6 \ub9e4\uac1c DNA \ubcf5\uad6c\ub97c \ucd09\uc9c4\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

\uace0\uc26c S, \ub958 B, \uc655 Y, \ud558\uc624 Q, \uc800\uc6b0 Z. \uc140 \ub300\ud45c<\/em>. 2015;13(7):1396-1406. doi:10.1016\/j.celrep.2015.10.006<\/p>\n

\ub178\ud654 \uc138\ud3ec \ubaa8\ub378\uc5d0\uc11c \uc218\ub450\ub300\uc0c1\ud3ec\uc9c4 \ubc14\uc774\ub7ec\uc2a4 \uac10\uc5fc(\ub300\uc0c1\ud3ec\uc9c4) \uc911 \uba74\uc5ed\ub178\ud654\uc758 \uc5ed\ud560\uc5d0 \ub300\ud55c \ud1b5\ucc30\ub825<\/a><\/h5>\n

\uae40\uc790, \ubc15\uc131\uaddc, \ucfe0\ub9c8 \uc5e0, \uc774\ucca0\ud76c, \uc2e0\uc624\uc5d0\uc2a4. \uc628\ucf54\ud0c0\uac9f<\/em>. 2015;6(34):35324-35343. doi:10.18632\/oncotarget.6117<\/p>\n

\ud504\ub85c\uac8c\ub9ac\uc544 \uc138\ud3ec\uc758 \uc99d\uc2dd\uc740 \uc138\ud3ec\uc678 \uae30\uc9c8 \ub2e8\ubc31\uc9c8\uc758 \ubc1c\ud604\uc744 \ud1b5\ud574 \ub77c\ubbf8\ub098 \uad00\ub828 \ud3f4\ub9ac\ud3a9\ud0c0\uc774\ub4dc 2\u03b1(LAP2\u03b1)\uc5d0 \uc758\ud574 \ud5a5\uc0c1\ub429\ub2c8\ub2e4.<\/a><\/h5>\n

Vidak S, Kubben N, Dechat T, Foisner R. \uc9c4\uc2a4 \ub370\ube0c<\/em>. 2015;29(19):2022-2036. doi:10.1101\/gad.263939.115<\/p>\n

\ud45c\ud604\ud615 \uc758\uc874\uc801 \uacf5\ubc1c\ud604 \uc720\uc804\uc790 \ud074\ub7ec\uc2a4\ud130: \uc815\uc0c1 \ubc0f \uc870\uae30 \ub178\ud654\uc5d0 \ub300\ud55c \uc751\uc6a9<\/a><\/h5>\n

\uc655 K, \ub2e4\uc2a4 A, \uc29d ZM, \uce74\uc624 K, \ud558\ub128\ud560\ub9ac S. IEEE\/ACM Trans Comput Biol Bioinform<\/em>. 2015;12(1):30-39. doi:10.1109\/TCBB.2014.2359446<\/p>\n

\uba54\ud2f8\ub80c\ube14\ub8e8\ub294 \ud504\ub85c\uac8c\ub9ac\uc544\uc758 \ud575\uacfc \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uc774\uc0c1\uc744 \uc644\ud654\ud569\ub2c8\ub2e4<\/a><\/h5>\n

Xiong ZM, \ucd5c JY, \uc655 K, \uc678. \ub178\ud654\uc138\ud3ec<\/em>. 2016;15(2):279-290. doi:10.1111\/acel.12434<\/p>\n

\n

2014<\/strong><\/p>\n

\uc124\ud3ec\ub77c\ud310\uc740 \ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544 \uc12c\uc720\uc544\uc138\ud3ec\uc5d0\uc11c \ud504\ub85c\uac8c\ub9b0 \ud074\ub9ac\uc5b4\ub7f0\uc2a4\ub97c \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4.<\/a><\/h5>\n

\uac00\ube0c\ub9ac\uc5d8 D, Roedl D, \uace0\ub4e0 LB, \uc790\ubc1c\ub9ac K. \ub178\ud654\uc138\ud3ec<\/em>. 2015;14(1):78-91. doi:10.1111\/acel.12300<\/p>\n

\ud504\ub85c\uac8c\ub9ac\uc544\uc5d0\uc11c \ud3f4\ub9ac(ADP-\ub9ac\ubcf4\uc2a4) \uc911\ud569\ud6a8\uc18c 1\uc758 \ub2e4\uc6b4\ub808\uade4\ub808\uc774\uc158\uc744 \ud1b5\ud55c \ud3c9\ud65c\uadfc \uc138\ud3ec \uc0ac\uba78 \uc81c\uc5b4 \uba54\ucee4\ub2c8\uc998<\/a><\/p>\n

\uc7a5 H, \uc29d ZM, \uce74\uc624 K. Proc Natl Acad Sci USA<\/em>. 2014;111(22):E2261-E2270. doi:10.1073\/pnas.1320843111<\/p>\n

\n

2013<\/strong><\/p>\n

\uba54\ud2f8\ud2b8\ub79c\uc2a4\ud37c\ub77c\uc81c Suv39h1\uc744 \uace0\uac08\uc2dc\ud0a4\uba74 \ud504\ub85c\uac8c\ub9ac\uc544 \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc5d0\uc11c DNA \ubcf5\uad6c\uac00 \uac1c\uc120\ub418\uace0 \uc218\uba85\uc774 \uc5f0\uc7a5\ub429\ub2c8\ub2e4.<\/a><\/h5>\n

\ub958\ube44, \uc655\uc988, \uc7a5\uc5d8, \uace0\uc2dc\uc528, \uc815\ud5c8, \uc800\uc6b0\uc988. \uad6d\ubbfc \uacf5\ub3d9\uccb4<\/em>. 2013;4:1868. doi:10.1038\/ncomms2885<\/p>\n

Hutchinson-Gilford \ud504\ub85c\uac8c\ub9ac\uc544 \uc99d\ud6c4\uad70\uc5d0\uc11c \uac8c\ub188 \uc870\uc9c1, \ud788\uc2a4\ud1a4 \uba54\ud2f8\ud654 \ubc0f DNA-\ub77c\ubbfc A\/C \uc0c1\ud638 \uc791\uc6a9\uc758 \uc0c1\uad00 \uad00\uacc4 \ubcc0\ud654<\/a><\/h5>\n

McCord RP, Nazario-Toole A, Zhang H, et al. \uac8c\ub188 \uc5f0\uad6c<\/em>. 2013;23(2):260-269. doi:10.1101\/gr.138032.112<\/p>\n

\uc704\uc131 \ud5e4\ud14c\ub85c\ud06c\ub85c\ub9c8\ud2f4\uc758 \uace0\ucc28 \ud3bc\uce68\uc740 \uc138\ud3ec \ub178\ud654\uc758 \uc77c\uad00\ub418\uace0 \ucd08\uae30\uc758 \uc0ac\uac74\uc785\ub2c8\ub2e4.<\/a><\/h5>\n

\uc2a4\uc644\uc2a8 EC, \ub9e4\ub2dd B, \uc7a5 H, \ub85c\ub80c\uc2a4 JB. \uc81c\uc774 \uc140 \ubc14\uc774\uc62c<\/em>. 2013;203(6):929-942. doi:10.1083\/jcb.201306073<\/p>\n

iPS\uc138\ud3ec\ub85c\ubd80\ud130 \uc9c0\ubc29\uc138\ud3ec \ubd84\ud654\uc758 \uc720\uc804\uc790 \uc720\ub3c4 \ub124\ud2b8\uc6cc\ud06c\uc5d0\uc11c \ud504\ub85c\uac8c\ub9b0\uc758 \uc5b5\uc81c \uc5ed\ud560<\/a><\/h5>\n

Xiong ZM, LaDana C, Wu D, Cao K. \ub178\ud654(Albany NY)<\/em>. 2013;5(4):288-303. doi:10.18632\/aging.100550<\/p>\n

\n

2012<\/strong><\/p>\n

\ud575 \ubaa8\uc591\uc758 \uc790\ub3d9\ud654\ub41c \uc774\ubbf8\uc9c0 \ubd84\uc11d: \uc870\uae30 \ub178\ud654\ub41c \uc138\ud3ec\uc5d0\uc11c \ubb34\uc5c7\uc744 \ubc30\uc6b8 \uc218 \uc788\uc744\uae4c?<\/a><\/h5>\n

\ub4dc\ub9ac\uc2a4\ucf5c MK, \uc54c\ubc14\ub2c8\uc2a4 JL, \uc2dc\uc639 ZM, \uba54\uc77c\uba3c M, \ub85c\uc800\ud2b8 W, \uce74\uc624 K.\u00a0\ub178\ud654(Albany NY)<\/em>. 2012;4(2):119-132. doi:10.18632\/aging.100434<\/p>\n

\ud504\ub85c\uac8c\ub9ac\uc544: \uc138\ud3ec \uc0dd\ubb3c\ud559\uc73c\ub85c\ubd80\ud130\uc758 \uc804\ud658\uc801 \ud1b5\ucc30\ub825<\/a><\/h5>\n

\uace0\ub4e0 LB, \uce74\uc624 K, \ucf5c\ub9b0\uc2a4 FS. \uc81c\uc774 \uc140 \ubc14\uc774\uc62c<\/em>. 2012;199(1):9-13. doi:10.1083\/jcb.201207072<\/p>\n

\ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544 \uc99d\ud6c4\uad70\uc5d0 \ub300\ud55c \ud504\ub85c\ud14c\uc624\ubbf9 \uc5f0\uad6c: \uc870\uae30 \ub178\ud654 \uc9c8\ud658\uc5d0 \ub300\ud55c 2D \ud06c\ub85c\ub9c8\ud1a0\uadf8\ub798\ud53c\uc758 \uc751\uc6a9<\/a><\/h5>\n

\uc655 L, \uc591 W, \uc8fc W, \ub4f1 \uc0dd\ud654\ud559 \uc0dd\ubb3c\ub9ac \uc5f0\uad6c \ucee4\ubba4\ub2c8\ud2f0<\/em>. 2012;417(4):1119-1126. doi:10.1016\/j.bbrc.2011.12.056<\/p>\n

\ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544 \uc99d\ud6c4\uad70 \ud658\uc790\uc758 \uc21c\uc218 \uc131\uc778 \uc904\uae30 \uc138\ud3ec\ub294 \uc0dd\uccb4 \ub0b4\uc5d0\uc11c \ub0ae\uc740 \uc218\uc900\uc758 \ud504\ub85c\uac8c\ub9b0\uc744 \ubc1c\ud604\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Wenzel V, Roedl D, Gabriel D, et al. \ubc14\uc774\uc62c \uc624\ud508<\/em>. 2012;1(6):516-526. doi:10.1242\/bio.20121149<\/p>\n

\n

2011<\/strong><\/p>\n

SNP \uc5b4\ub808\uc774\uc640 \uba54\uc774\ud2b8 \uc30d \uc2dc\ud000\uc2f1\uc744 \ud1b5\ud55c \uad6c\uc131\uc801 \ubc0f \ubcf5\uc81c \uc2a4\ud2b8\ub808\uc2a4\ub85c \uc778\ud55c \uac8c\ub188 \uad6c\uc870\uc801 \ubcc0\uc774\uc758 \ube44\uad50<\/a><\/h5>\n

\uc544\ub97c\ud2b8 MF, \uc624\uc988\ub370\ubbf8\ub974 AC, \ubc84\ucf08\ub79c\ub4dc SR, \ub9ac\uc628\uc2a4 RH \uc8fc\ub2c8\uc5b4, \uae00\ub85c\ubc84 TW, \uc70c\uc2a8 TE. \uc720\uc804\ud559<\/em>. 2011;187(3):675-683. doi:10.1534\/genetics.110.124776<\/p>\n

\ud558\uc774\ub4dc\ub85d\uc2dc\uc6b0\ub808\uc544\ub294 \uc778\uac04 \uc138\ud3ec\uc5d0\uc11c \uc0c8\ub85c\uc6b4 \ubcf5\uc0ac \uc218 \ubcc0\ud615\uc744 \uc720\ub3c4\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

\uc544\ub97c\ud2b8 MF, \uc624\uc988\ub370\ubbf8\ub974 AC, \ubc84\ucf08\ub79c\ub4dc SR, \uc70c\uc2a8 TE, \uae00\ub85c\ubc84 TW. Proc Natl Acad Sci USA<\/em>. 2011;108(42):17360-17365. doi:10.1073\/pnas.1109272108<\/p>\n

\ud504\ub85c\uac8c\ub9b0\uacfc \ud154\ub85c\ubbf8\uc5b4 \uae30\ub2a5 \uc7a5\uc560\ub294 \uc815\uc0c1 \uc778\uac04 \uc12c\uc720\uc544\uc138\ud3ec\uc5d0\uc11c \uc138\ud3ec \ub178\ud654\ub97c \uc720\ubc1c\ud558\uae30 \uc704\ud574 \ud611\ub825\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Cao K, Blair CD, Faddah DA \ub4f1. \uc81c\uc774\ud074\ub9b0\uc778\ubca0\uc2a4\ud2b8<\/em>. 2011;121(7):2833-2844. doi:10.1172\/JCI43578<\/p>\n

\ub77c\ud30c\ub9c8\uc774\uc2e0\uc740 Hutchinson-Gilford progeria \uc99d\ud6c4\uad70 \uc138\ud3ec\uc5d0\uc11c \uc138\ud3ec \ud45c\ud604\ud615\uc744 \uc5ed\uc804\uc2dc\ud0a4\uace0 \ub3cc\uc5f0\ubcc0\uc774 \ub2e8\ubc31\uc9c8 \uc81c\uac70\ub97c \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4.<\/a><\/h5>\n

Cao K, Graziotto JJ, \ube14\ub808\uc5b4 CD, \uc678. \uacfc\ud559 \ubc88\uc5ed \uc758\ud559<\/em>. 2011;3(89):89ra58. doi:10.1126\/scitranslmed.3002346<\/p>\n

\ub2e4\uc591\ud55c \ud575\ud2b9\uc774 \ub178\ud654\uc7a5\uc560\uc640 \uad00\ub828\ub41c \ud575\ud615\ud0dc\uc758 \uacc4\uc0b0\uc601\uc0c1 \ubd84\uc11d<\/a><\/h5>\n

\ucd5c S, \uc655 W, \ub9ac\ubca0\uc774\ub85c AJ, et al. \ud575<\/em>. 2011;2(6):570-579. \ub3c4\uc774:10.4161\/nucl.2.6.17798<\/p>\n

CTP: \ud3ec\uc2a4\ud3ec\ucf5c\ub9b0 \uc2dc\ud2f0\ub51c\ub9b4\ud2b8\ub79c\uc2a4\ud37c\ub77c\uc81c \u03b1(CCT\u03b1) \ubc0f \ub77c\ubbfc\uc740 \ud3ec\uc2a4\ud30c\ud2f0\ub51c\ucf5c\ub9b0 \ud569\uc131\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\uc9c0 \uc54a\uace0 \ud575\ub9c9 \uad6c\uc870\ub97c \ubcc0\uacbd\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

\uac8c\ub9ad K, \ub9ac\uc9c0\uc6e8\uc774 \ub178\uc2a4\ub2e4\ucf54\ud0c0\uc8fc \ubc14\uc774\uc624\ud0b4 \ubc14\uc774\uc624\ud53c\uc2a4 \uc561\ud0c0<\/em>. 2011;1811(6):377-385. doi:10.1016\/j.bbalip.2011.04.001<\/p>\n

\ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544 \uc99d\ud6c4\uad70\uc5d0\uc11c \uc5f0\ub839\uc5d0 \ub530\ub978 MMP-3 \uc190\uc2e4<\/a><\/h5>\n

Harten IA, Zahr RS, Lemire JM \ub4f1. J Gerontol A Biol Sci Med Sci<\/em>. 2011;66(11):1201-1207. doi:10.1093\/gerona\/glr137<\/p>\n

LMNA \uc720\uc804\uc790\uc758 \ub0ae\uace0 \ub192\uc740 \ubc1c\ud604 \ub300\ub9bd\uc720\uc804\uc790: \uce35\uc0c1\ubcd1 \uc9c8\ubcd1 \ubc1c\ubcd1\uc5d0 \ub300\ud55c \uc758\ubbf8<\/a><\/h5>\n

\ub85c\ub4dc\ub9ac\uac8c\uc2a4 S, \uc5d0\ub9ad\uc2a8 M. \ud50c\ub85c\uc2a4 \uc6d0<\/em>. 2011;6(9):e25472. doi:10.1371\/journal.pone.0025472<\/p>\n

\ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544 \uc99d\ud6c4\uad70\uc5d0\uc11c\uc758 \uc904\uae30\uc138\ud3ec \uace0\uac08<\/a><\/h5>\n

Rosengardten Y, McKenna T, Grochov\u00e1 D, Eriksson M. \ub178\ud654\uc138\ud3ec<\/em>. 2011;10(6):1011-1020. doi:10.1111\/j.1474-9726.2011.00743.x<\/strong><\/p>\n

\n

2010<\/strong><\/p>\n

\ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544 \uc99d\ud6c4\uad70\uc5d0\uc11c\uc758 \uacb0\ud568 \uc788\ub294 \ub77c\ubbfc A-Rb \uc2e0\ud638 \uc804\ub2ec \ubc0f \ud30c\ub124\uc2e4\ud2b8\ub79c\uc2a4\ud37c\ub77c\uc81c \uc5b5\uc81c\uc5d0 \uc758\ud55c \uc5ed\uc804<\/a><\/h5>\n

Marji J, O'Donoghue SI, McClintock D \ub4f1. \ud50c\ub85c\uc2a4 \uc6d0<\/em>. 2010;5(6):e11132. 2010\ub144 6\uc6d4 15\uc77c \ucd9c\ud310. doi:10.1371\/journal.pone.0011132<\/p>\n

\ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \uc870\ub85c\uc99d\uc758 \uc2ec\ud608\uad00 \ubcd1\ub9ac\ud559: \ub178\ud654\uc758 \ud608\uad00 \ubcd1\ub9ac\ud559\uacfc\uc758 \uc0c1\uad00\uad00\uacc4<\/a><\/h5>\n

\uc62c\ub9ac\ube0c M, \ud558\ud150 I, \ubbf8\uccbc R, \uc678. \ub3d9\ub9e5\uacbd\ud654\uc99d \ud608\uc804 \ud608\uad00\uc0dd\ubb3c\ud559<\/em>. 2010;30(11):2301-2309. \ub3c4\uc774:10.1161\/ATVBAHA.110.209460<\/p>\n

\ud5c8\uce5c\uc2a8 \uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544 \ud658\uc790\uc758 \uc12c\uc720\uc544\uc138\ud3ec\uc5d0\uc11c \uc0b0\ud654\ub41c \ub2e8\ubc31\uc9c8 \ucd95\uc801\uc5d0 \ub300\ud55c \ud504\ub85c\uac8c\ub9b0\uc758 \ud6a8\uacfc<\/a><\/h5>\n

Viteri G, \uc815 YW, Stadtman ER. Mech \ub178\ud654 \uac1c\ubc1c<\/em>. 2010;131(1):2-8. doi:10.1016\/j.mad.2009.11.006<\/p>\n

\n

2009<\/strong><\/p>\n

\ubcf5\uc81c \uc2a4\ud2b8\ub808\uc2a4\ub294 \ub2e4\ud615\uc131 \ubc0f \ubcd1\uc6d0\uc131 \ubcc0\ud615\uacfc \uc720\uc0ac\ud55c \uc778\uac04 \uc138\ud3ec\uc758 \uac8c\ub188 \uc804\uccb4 \ubcf5\uc0ac \ubc88\ud638 \ubcc0\ud654\ub97c \uc720\ub3c4\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Arlt MF, Mulle JG, Schaibley VM \ub4f1.\u00a0\uc554 \uc81c\uc774 \ud5d8 \uc81c\ub137<\/em>. 2009;84(3):339-350. doi:10.1016\/j.ajhg.2009.01.024<\/p>\n

NURD \ubcf5\ud569\uccb4 \uc190\uc2e4\uc744 \ud1b5\ud55c \ub178\ud654 \uad00\ub828 \ud06c\ub85c\ub9c8\ud2f4 \uacb0\ud568<\/a><\/h5>\n

Pegoraro G, Kubben N, Wickert U, G\u00f6hler H, Hoffmann K, Misteli T. \ub0b4\ucd94\ub7f4 \uc140 \ubc14\uc774\uc62c<\/em>. 2009;11(10):1261-1267. doi:10.1038\/ncb1971<\/strong><\/p>\n

\n

2008<\/strong><\/p>\n

\uc57c\uc0dd\ud615 \ub77c\ubbfc A \ub300\uc0ac\uc758 \uad50\ub780\uc740 \uc870\ub85c\uc99d \ud45c\ud604\ud615\uc744 \ucd08\ub798\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Candelario J, Sudhakar S, Navarro S, Reddy S, Comai L. \ub178\ud654\uc138\ud3ec<\/em>. 2008;7(3):355-367. doi:10.1111\/j.1474-9726.2008.00393.x<\/p>\n

\uc131\uc778\uc904\uae30\uc138\ud3ec\uc758 \ub77c\ubbfc A \uc758\uc874\uc801 \uc870\uc808 \ubd88\ub7c9\uc740 \ub178\ud654 \ucd09\uc9c4\uacfc \uad00\ub828\uc774 \uc788\uc74c<\/a><\/h5>\n

\uc2a4\uce90\ud53c\ub514 P, \ubbf8\uc2a4\ud154\ub9ac T. \ub0b4\ucd94\ub7f4 \uc140 \ubc14\uc774\uc62c<\/em>. 2008;10(4):452-459. doi:10.1038\/ncb1708<\/p>\n

Hutchinson-Gilford progeria \uc138\ud3ec\uc758 \uae30\uacc4\uc801 \uac10\uc218\uc131\uacfc \ud575 \uac15\uc131 \uc99d\uac00: farnesyltransferase \uc5b5\uc81c\uc81c\uc758 \ud6a8\uacfc<\/a><\/h5>\n

Verstraeten VL, Ji JY, Cummings KS, Lee RT, Lammerding J. \ub178\ud654\uc138\ud3ec<\/em>. 2008;7(3):383-393. doi:10.1111\/j.1474-9726.2008.00382.x<\/p>\n

\n

2007<\/strong><\/p>\n

\ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc(Hutchinson-Gilford) \ud504\ub85c\uac8c\ub9ac\uc544 \uc99d\ud6c4\uad70\uc5d0\uc11c \uacfc\uc789 \ubc1c\ud604\ub418\ub294 \ub77c\ubbfc A \ub2e8\ubc31\uc9c8 \ub3d9\ud615\uccb4\ub294 \ud504\ub85c\uac8c\ub9ac\uc544 \uc138\ud3ec\uc640 \uc815\uc0c1 \uc138\ud3ec\uc758 \uc720\uc0ac \ubd84\uc5f4\uc744 \ubc29\ud574\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Cao K, Capell BC, Erdos MR, Djabali K, Collins FS. Proc Natl Acad Sci USA<\/em>. 2007;104(12):4949-4954. doi:10.1073\/pnas.0611640104<\/p>\n

\uc778\uac04 \ub178\ud654\ub97c \uac00\uc18d\ud654\ud558\ub294 \uac83\uc73c\ub85c \uc54c\ub824\uc9c4 \ub3cc\uc5f0\ubcc0\uc774 \ub77c\ubbfc A\ub85c \uc778\ud55c \uc138\ud3ec \ubd84\uc5f4 \ubc0f \uc138\ud3ec \uc8fc\uae30 \uc9c4\ud589\uc758 \ubcc0\ud654<\/a><\/h5>\n

Dechat T, Shimi T, Adam SA, \uc678. Proc Natl Acad Sci USA<\/em>. 2007;104(12):4955-4960. doi:10.1073\/pnas.0700854104<\/p>\n

\uce35\uc0c1\ubcd1\uc99d\uc5d0\uc11c\uc758 \uc804\ub77c\ubbfc A \ucc98\ub9ac \ubc0f \uc774\uc885\uc5fc\uc0c9\uc9c8 \uc5ed\ud559<\/a><\/h5>\n

Maraldi NM, Mattioli E, Lattanzi G, \uc678. Adv \ud6a8\uc18c \uc870\uc808\uc81c<\/em>. 2007;47:154-167. doi:10.1016\/j.advenzreg.2006.12.016<\/p>\n

\ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc(Hutchinson-Gilford) \ud504\ub85c\uac8c\ub9ac\uc544\ub97c \uc720\ubc1c\ud558\ub294 \ub77c\ubbfc A\uc758 \ub3cc\uc5f0\ubcc0\uc774 \ud615\ud0dc\ub294 \uc778\uac04 \ud53c\ubd80\uc758 \uc138\ud3ec \ub178\ud654 \ubc14\uc774\uc624\ub9c8\ucee4\uc785\ub2c8\ub2e4.<\/a><\/h5>\n

McClintock D, Ratner D, Lokuge M, \uc678. \ud50c\ub85c\uc2a4 \uc6d0<\/em>. 2007;2(12):e1269. 2007\ub144 12\uc6d4 5\uc77c \ucd9c\ud310. doi:10.1371\/journal.pone.0001269<\/p>\n

\ube44\uc815\uc0c1\uc801\uc778 LMNA \ub3cc\uc5f0\ubcc0\uc774\uc640 \uad00\ub828\ub41c \ud504\ub85c\uac8c\ub9b0 \ubc1c\ud604 \uc99d\uac00\ub294 \uc2ec\uac01\ud55c \ud504\ub85c\uac8c\ub85c\uc774\ub4dc \uc99d\ud6c4\uad70\uc744 \uc720\ubc1c\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

Moulson CL, Fong LG, Gardner JM \ub4f1 \ud5d8 \ubb34\ud0c0\ud2b8<\/em>. 2007;28(9):882-889. doi:10.1002\/humu.20536<\/p>\n

\n

2006<\/strong><\/p>\n

Aggrecan \ubc1c\ud604\uc740 Hutchinson-Gilford Progeria \uc99d\ud6c4\uad70 \ud53c\ubd80 \uc12c\uc720\uc544\uc138\ud3ec\uc5d0\uc11c \uc0c1\ub2f9\ud788 \ube44\uc815\uc0c1\uc801\uc73c\ub85c \uc0c1\ud5a5 \uc870\uc808\ub429\ub2c8\ub2e4.<\/a><\/h5>\n

\ub808\ub9c8\uc774\uc5b4 JM, \ud30c\ud2f0\uc2a4 C, \uace0\ub4e0 LB, \uc0cc\ub514 JD, \ud234 BP, \ubc14\uc774\uc2a4 AS. Mech \ub178\ud654 \uac1c\ubc1c<\/em>. 2006;127(8):660-669. doi:10.1016\/j.mad.2006.03.004<\/p>\n

Hutchinson-Gilford progeria \ub3cc\uc5f0\ubcc0\uc774 \ub77c\ubbfc A\ub294 \ud56d-\ub77c\ubbfc A G608G \ud56d\uccb4\uc5d0 \uc758\ud574 \uac10\uc9c0\ub418\ub294 \uac83\ucc98\ub7fc \uc8fc\ub85c \uc778\uac04 \ud608\uad00 \uc138\ud3ec\ub97c \ud45c\uc801\uc73c\ub85c \ud569\ub2c8\ub2e4.<\/a><\/h5>\n

\ub9e4\ud074\ub9b0\ud1a1 D, \uace0\ub4e0 LB, \uc790\ubc1c\ub9ac K. Proc Natl Acad Sci USA<\/em>. 2006;103(7):2154-2159. doi:10.1073\/pnas.0511133103<\/strong><\/p>\n

\n

2005<\/strong><\/p>\n

\uc57d\ubb3c \uce58\ub8cc\ub97c \ud1b5\ud55c \ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \ud504\ub85c\uac8c\ub9ac\uc544\uc758 \uc774\uc885\uc5fc\uc0c9\uc9c8 \uc870\uc9c1 \uad6c\ucd9c<\/a><\/h5>\n

Columbaro M, Capanni C, Mattioli E, \uc678. \uc138\ud3ec \ubd84\uc790 \uc0dd\uba85 \uacfc\ud559<\/em>. 2005;62(22):2669-2678. doi:10.1007\/s00018-005-5318-6<\/p>\n

Hutchinson-Gilford progeria\uc5d0\uc11c \ub3cc\uc5f0\ubcc0\uc774 \ub77c\ubbfc A\uc758 \ubd88\uc644\uc804\ud55c \ucc98\ub9ac\ub85c \uc778\ud574 \ud575 \uc774\uc0c1\uc774 \ubc1c\uc0dd\ud558\uace0 \uc774\ub294 farnesyltransferase \uc5b5\uc81c\ub85c \uc5ed\uc804\ub429\ub2c8\ub2e4.<\/a><\/h5>\n

\uae00\ub9b0 MW, \uae00\ub85c\ubc84 TW. \ud5d8 \ubab0 \uc81c\ub124<\/em>. 2005;14(20):2959-2969. doi:10.1093\/hmg\/ddi326<\/p>\n

\uce35\uc0c1\ubcd1 \uae30\ubc18 \uc870\uae30 \ub178\ud654\uc758 \uc720\uc804\uccb4 \ubd88\uc548\uc815\uc131<\/a><\/h5>\n

Liu B, Wang J, Chan KM \ub4f1 \ub0b4\ucd94\ub7f4 \uba54\ub4dc<\/em>. 2005;11(7):780-785. doi:10.1038\/nm1266<\/p>\n

\uc0c8\ub85c\uc6b4 \ud504\ub85c\uac8c\ub9b0 \uc0c1\ud638 \uc791\uc6a9 \ud30c\ud2b8\ub108 \ub2e8\ubc31\uc9c8 hnRNP E1, EGF, Mel 18 \ubc0f UBC9\ub294 \ub77c\ubbfc A\/C\uc640 \uc0c1\ud638 \uc791\uc6a9\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

\uc885 N, Radu G, Ju W, \ube0c\ub77c\uc6b4 WT. \uc0dd\ud654\ud559 \uc0dd\ubb3c\ub9ac \uc5f0\uad6c \ucee4\ubba4\ub2c8\ud2f0<\/em>. 2005;338(2):855-861. doi:10.1016\/j.bbrc.2005.10.020<\/p>\n

\n

2004<\/strong><\/p>\n

\ub3cc\uc5f0\ubcc0\uc774 \ub77c\ubbfc A\uc758 \ucd95\uc801\uc740 Hutchinson-Gilford progeria \uc99d\ud6c4\uad70\uc5d0\uc11c \ud575 \uad6c\uc870\uc758 \uc810\uc9c4\uc801\uc778 \ubcc0\ud654\ub97c \uc720\ubc1c\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

\uace8\ub4dc\uba3c RD, \uc288\ub9c8\ucee4 DK, \uc5d0\ub974\ub418\uc2dc MR \ub4f1 Proc Natl Acad Sci USA<\/em>. 2004;101(24):8963-8968. doi:10.1073\/pnas.0402943101<\/strong><\/p>\n

\n

2003<\/strong><\/p>\n

\ub77c\ubbfc A\uc758 \uc7ac\ubc1c\uc131 \uc2e0\uc0dd \uc810 \ub3cc\uc5f0\ubcc0\uc774\ub294 \ud5c8\uce5c\uc2a8-\uae38\ud3ec\ub4dc \uc870\ub85c\uc99d \uc99d\ud6c4\uad70\uc744 \uc720\ubc1c\ud569\ub2c8\ub2e4.<\/a><\/h5>\n

\uc5d0\ub9ad\uc2a8 M, \ube0c\ub77c\uc6b4 WT, \uace0\ub4e0 LB, \uc678 \uc790\uc5f0<\/em>. 2003;423(6937):293-298. \ub3c4\uc774:10.1038\/nature01629<\/p>\n