{"id":8398,"date":"2020-11-02T18:57:17","date_gmt":"2020-11-02T23:57:17","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?p=8398"},"modified":"2022-12-09T06:43:20","modified_gmt":"2022-12-09T11:43:20","slug":"2020-workshop","status":"publish","type":"post","link":"https:\/\/www.progeriaresearch.org\/ko\/2020\/11\/02\/2020-workshop\/","title":{"rendered":"PRF 10\ubc88\uc9f8 \uad6d\uc81c \uacfc\ud559 \uc6cc\ud06c\uc20d"},"content":{"rendered":"

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[\/et_pb_fullwidth_image][\/et_pb_section][et_pb_section fb_built=”1″ use_custom_gutter=”on” gutter_width=”1″ specialty=”on” padding_left_1=”35px” padding_left_2=”35px” padding_2_tablet=”|||0px” padding_2_phone=”|||0px” padding_2_last_edited=”on|desktop” module_class_1=”sidebar-secondary-nav” module_class=”handprint-bg” _builder_version=”4.16″ background_image=”https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/blue-handprint-only.png” parallax=”on” parallax_method=”off” inner_width=”100%” inner_max_width=”100%” custom_padding=”0|0px|54px|0px|false|false” z_index_tablet=”500″ border_width_top=”10px” border_color_top=”#8fd2ed” use_custom_width=”on” width_unit=”off” custom_width_percent=”100%” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_sidebar area=”et_pb_widget_area_24″ disabled_on=”on|on|off” admin_label=”Scientific meetings sidebar” module_class=”subpage-sidebars” _builder_version=”4.16″ text_orientation=”left” animation_style=”fade” hover_enabled=”0″ z_index_tablet=”500″ border_width_right=”5px” global_colors_info=”{}” sticky_enabled=”0″ locked=”off”][\/et_pb_sidebar][\/et_pb_column][et_pb_column type=”3_4″ specialty_columns=”3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_row_inner custom_padding_last_edited=”on|phone” _builder_version=”4.16″ custom_padding=”39.4375px|35px|35px||false|false” custom_padding_tablet=”|35px||35px||true” custom_padding_phone=”” animation_direction=”top” global_colors_info=”{}”][et_pb_column_inner saved_specialty_column_type=”3_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

370\uac1c \uc774\uc0c1<\/strong> \ub4f1\ub85d\uc790 30<\/strong> 1\uac1c\uad6d\uc774 \ucc38\uc11d\ud588\uc2b5\ub2c8\ub2e4\uc131<\/sup> \uc774\uc81c \uc6f9 \uae30\ubc18\uc758 \uacfc\ud559 \ud68c\uc758\ub97c \ub9cc\ub098\ubcf4\uc138\uc694!<\/h4>\n

[\/et_pb_text][et_pb_image src=”https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2020\/07\/Registrant-Map-1.jpg” title_text=”Registrant-Map” align=”center” admin_label=”map” _builder_version=”4.16″ _module_preset=”default” custom_margin=”10px||20px||false|false” global_colors_info=”{}”][\/et_pb_image][et_pb_image src=”https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2020\/12\/Complete-Photo.jpg” title_text=”Complete-Photo” align=”center” admin_label=”participants” _builder_version=”4.16″ _module_preset=”default” custom_margin=”10px||15px||false|false” global_colors_info=”{}”][\/et_pb_image][et_pb_text admin_label=”video clip text” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

2020\ub144 \uad6d\uc81c \uc6cc\ud06c\uc20d\uc758 \uc774 \ud074\ub9bd\uc744 \uc990\uae30\uc2dc\uae30 \ubc14\ub78d\ub2c8\ub2e4.
\u201c\uac00\ub2a5\uc131 \uc5f0\uad6c, \uc0b6\uc758 \ud655\uc7a5\u201d \uc6e8\ube44\ub098<\/h4>\n

[\/et_pb_text][et_pb_video src=”https:\/\/www.youtube.com\/watch?v=pedD1zXVw1o&feature=youtu.be” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_video][et_pb_text admin_label=”disclaimer” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

\u00a0\ubaa8\ub4e0 \uad8c\ub9ac\ub294 \ubcf4\ud638\ub429\ub2c8\ub2e4. \uc774 \ud504\ub808\uc820\ud14c\uc774\uc158\uc744 \uc5b4\ub5a4 \uc2dd\uc73c\ub85c\ub4e0 \ub2e4\uc6b4\ub85c\ub4dc, \ubcf5\uc0ac, \ubc30\ud3ec \ub610\ub294 \uc218\uc815\ud558\uc9c0 \ub9c8\uc2ed\uc2dc\uc624.<\/i><\/p>\n

[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner _builder_version=”4.16″ _module_preset=”default” custom_padding=”|35px||||” global_colors_info=”{}”][et_pb_column_inner saved_specialty_column_type=”3_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=”Chat Questions” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

\ub2f5\ubcc0\uc774 \uc5c6\ub294 \ucc44\ud305 \uc9c8\ubb38<\/strong><\/h4>\n

[\/et_pb_text][et_pb_toggle title=”To Dr. Francis Collins: Question: From Mansoor Amiji: Dr. Collins, have you looked at the biodistribution of the PPPMO upon systemic ” open_toggle_background_color=”#f7f7f7″ closed_toggle_text_color=”#ffffff” closed_toggle_background_color=”#00b2e2″ icon_color=”#ffc15e” open_icon_color=”#ffc15e” admin_label=”Collins Q&A” _builder_version=”4.16″ _module_preset=”default” title_text_color=”#00b2e2″ title_font=”||||||||” background_color=”#ffffff” custom_margin=”||25px” custom_padding=”|50px||50px||true” border_width_all=”0px” global_colors_info=”{}”]<\/p>\n


\"\"\ub2f5\ubcc0:<\/strong> PK\/PD \uc5f0\uad6c\ub294 \uc2ec\uc7a5, \ub300\ub3d9\ub9e5 \ubc0f \uc2e0\uc7a5\uc5d0\uc11c 100% \uc0dd\uccb4\uc774\uc6a9\ub960\uc744 \ub098\ud0c0\ub0c8\uc2b5\ub2c8\ub2e4. \uc870\uc9c1\ud559\uc801 \uac80\uc0ac \ubc0f PK\/PD \ub370\uc774\ud130\uc5d0 \ub530\ub974\uba74 \uc2e0\uc7a5\uc740 \ucd95\uc801\uc774 \uc2dc\uc0ac\ub418\ub294 \uc720\uc77c\ud55c \uc870\uc9c1\uc774\uc5c8\uc2b5\ub2c8\ub2e4. SRP-2001\uc758 \ub2e8\uc77c \ud22c\uc5ec\ub7c9\uc740 PPMO\uac00 \uc2ec\uc7a5\uc5d0\uc11c \ube60\ub974\uac8c \uc81c\uac70(2\uc2dc\uac04 \uc774\ub0b4), \ub300\ub3d9\ub9e5\uc5d0\uc11c 4\uc2dc\uac04 \uc774\ub0b4\uc5d0 \uc81c\uac70\ub418\uc5c8\uc9c0\ub9cc \uc2e0\uc7a5\uc5d0\uc11c 48\uc2dc\uac04 \uc2dc\uc810\uae4c\uc9c0 \uc9c0\uc18d\ub418\uc5c8\uc74c\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4. \uc815\ub7c9\uc801 ddPCR\uc740 \uc9c0\uae08\uae4c\uc9c0 \ud14c\uc2a4\ud2b8\ud55c \ubaa8\ub4e0 \uc870\uc9c1(\ub300\ub3d9\ub9e5, \uc2ec\uc7a5, \uc2e0\uc7a5, \uac04, \ub300\ud1f4\uc0ac\ub450\uadfc, \ubf08)\uc5d0\uc11c G608G \uc554\ud638\ud654 \uc2a4\ud50c\ub77c\uc774\uc2a4 \uc5b5\uc81c \ud65c\ub3d9\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\uc9c0\ub9cc \ud65c\ub3d9\uc740 \uc870\uc9c1\uc5d0 \ub530\ub77c \ub2ec\ub790\uc2b5\ub2c8\ub2e4.<\/p>\n

\ud504\ub79c\uc2dc\uc2a4, \ub9c8\uc774\ud06c, \uc6e8\uc778<\/em><\/p>\n

[\/et_pb_toggle][et_pb_toggle title=”To Dr. Pinak Shah and Dr. Francesco Musumeci: Question: From RVB: Can magnesium\/calcium intake determine the degree of calcification in children with HGPS?” open_toggle_background_color=”#f7f7f7″ closed_toggle_text_color=”#ffffff” closed_toggle_background_color=”#00b2e2″ icon_color=”#ffc15e” open_icon_color=”#ffc15e” admin_label=”Shah & Musumeci Q&A” _builder_version=”4.16″ _module_preset=”default” title_text_color=”#00b2e2″ title_font=”||||||||” background_color=”#ffffff” custom_margin=”||25px” custom_padding=”|50px||50px||true” border_width_all=”0px” global_colors_info=”{}”]<\/p>\n

\"\"<\/strong>\ub2f5\ubcc0:<\/strong>\uc9c8\ubb38\uc5d0 \ub300\ud574 \uc194\uc9c1\ud788 \ub9d0\ud574\uc11c, \uc800\ub294 \uc774 \uc9c8\ubb38\uc5d0 \ub300\ud55c \ub2f5\uc744 \ubaa8\ub985\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc77c\ubc18\uc801\uc778 \uc131\uc778\uc758 \uacbd\uc6b0 \ud310\ub9c9 \uc11d\ud68c\ud654 \uc815\ub3c4\uc640 Mg\/Ca \uc12d\ucde8\ub7c9\uc744 \uc5f0\uad00\uc2dc\ud0a4\uc9c0 \uc54a\uc73c\uba70, \ub354 \uc2ec\ud55c \uc11d\ud68c\ud654\ub294 \ub2e4\ub978 \uc694\uc778 \ub54c\ubb38\uc77c \uac00\ub2a5\uc131\uc774 \ud07d\ub2c8\ub2e4.<\/p>\n

\ubc15\uc0ac \ud53c\ub099 \uc0e4<\/em><\/p>\n

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\"\"\ub2f5\ubcc0: <\/strong>\uc800\ub294 \uc0e4 \ubc15\uc0ac\uc758 \uc758\uacac\uc5d0 \ub3d9\uc758\ud569\ub2c8\ub2e4. \uc544\ub9c8\ub3c4 HGPS\uc758 \ud310\ub9c9 \uc11d\ud68c\ud654 \uc6d0\uc778\uc740 \ub178\uc778 \ud658\uc790\uc5d0\uc11c \ubcf4\ub294 \uc6d0\uc778\uacfc \ub2e4\ub97c \uac83\uc785\ub2c8\ub2e4. \uc800\ub294 \ub610\ud55c Ca\uc640 Mg \ub300\uc0ac\uc5d0 \ub300\ud55c \uc9c0\uc2dd\uc774 \uc5c6\uc2b5\ub2c8\ub2e4.<\/p>\n

\ubc15\uc0ac \ud504\ub780\uccb4\uc2a4\ucf54 \ubb34\uc2a4\uba54\uce58<\/em><\/p>\n

\u00a0<\/strong><\/p>\n

[\/et_pb_toggle][et_pb_toggle title=” To Dr. Vicente Andres: Question: From Andre Monteiro Da Rocha – University of Michigan: Do the mice lacking Lamin A develop DCM?” open_toggle_background_color=”#f7f7f7″ closed_toggle_text_color=”#ffffff” closed_toggle_background_color=”#00b2e2″ icon_color=”#ffc15e” open_icon_color=”#ffc15e” admin_label=”Andres Q&A” _builder_version=”4.16″ _module_preset=”default” title_text_color=”#00b2e2″ title_font=”||||||||” background_color=”#ffffff” custom_margin=”||25px” custom_padding=”|50px||50px||true” border_width_all=”0px” global_colors_info=”{}”]<\/p>\n

\"\"\ub2f5\ubcc0: <\/strong>\ub77c\ubbfc A\/C \ub110(\uc5d8\uc5e0\ub098<\/em>-\/-<\/sup>) \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc740 \uc2ec\uc7a5 \uae30\ub2a5 \uc0c1\uc2e4\uc744 \ub3d9\ubc18\ud55c DCM\uc744 \ubc1c\ubcd1\ud569\ub2c8\ub2e4. \uac8c\ub2e4\uac00, \uc774 \ub9c8\uc6b0\uc2a4\ub294 \uc2ec\uc7a5 \uc804\ub3c4 \uacb0\ud568\uacfc \uad11\ubc94\uc704\ud55c \uc2ec\uc7a5 \uc12c\uc720\uc99d\uc744 \ubcf4\uc774\uba70, \uc0dd\ud6c4 5-8\uc8fc\uc5d0 \uc870\uae30 \uc0ac\ub9dd\ud569\ub2c8\ub2e4(Auguste et al., 2018; Frock et al., 2012; Sullivan, 1999). \uadf8\ub7ec\ub098 \ub77c\ubbfc A(Fong et al., 2006) \ub610\ub294 \ub77c\ubbfc C(Coffinier et al., 2010)\ub9cc \uacb0\ud54d\ub41c \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc740 \uc2ec\uc7a5 \uacb0\ud568\uc744 \ubcf4\uc774\uc9c0 \uc54a\uc73c\uba70 \uc815\uc0c1\uc801\uc778 \uc218\uba85\uc744 \ubcf4\uc785\ub2c8\ub2e4.<\/p>\n

\ucc38\uace0\ubb38\ud5cc:
<\/strong>Auguste, G., Gurha, P., Lombardi, R., Coarfa, C., Willerson, JT, & Marian, AJ (2018). \uc2ec\uc7a5\uc5d0\uc11c \ud65c\uc131\ud654\ub41c FOXO \uc804\uc0ac \uc778\uc790 \uc5b5\uc81c\ub294 \uce35\uc0c1\ubcd1 \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc5d0\uc11c \uc0dd\uc874\uc744 \uc5f0\uc7a5\ud569\ub2c8\ub2e4.<\/em>. https:\/\/doi.org\/10.1161\/CIRCRESAHA.117.312052<\/a><\/p>\n

Coffinier, C., Jung, HJ, Li, Z., Nobumori, C., Yun, UJ, Farber, EA, Davies, BS, Weinstein, MM, Yang, SH, Lammerding, J., Farahani, JN, Bentolila, LA, Fong, LG, & Young, SG (2010). \ub77c\ubbfc A\uc758 \uc9c1\uc811 \ud569\uc131\uc740 \uc804\ub77c\ubbfc A \ud504\ub85c\uc138\uc2f1\uc744 \uc6b0\ud68c\ud558\uc5ec \uc12c\uc720\uc544\uc138\ud3ec\uc5d0\uc11c \ud575\uc758 \ubaa8\uc591\uc744 \ubcc0\ud615\uc2dc\ud0a4\uc9c0\ub9cc \uc0dd\uc950\uc5d0\uc11c\ub294 \uac80\ucd9c \uac00\ub2a5\ud55c \ubcd1\ub9ac\ud559\uc801 \ud2b9\uc9d5\uc774 \uc5c6\ub2e4. \uc0dd\ud654\ud559 \uc800\ub110<\/em>, 285<\/em>(27), 20818-20826. https:\/\/doi.org\/10.1074\/jbc.M110.128835<\/a><\/p>\n

Fong, LG, Bergo, MO, Young, SG, Fong, LG, Ng, JK, Lammerding, J., Vickers, TA, Meta, M., Cot\u00e9, N., Gavino, B., Qiao, X., Chang, SY, Young, SR, Yang, SH, Stewart, CL, Lee, RT, Bennett, CF, Bergo, MO, & Young, SG (2006). Prelamin A\uc640 lamin A\ub294 \ud575 \ub77c\ubbf8\ub098\uc5d0\uc11c \uc5c6\uc5b4\ub3c4 \ub418\ub294 \uac83\uc73c\ub85c \ubcf4\uc778\ub2e4. \uc784\uc0c1 \uc870\uc0ac \uc800\ub110<\/em>, 116<\/em>(3), 743-752. https:\/\/doi.org\/10.1172\/JCI27125.with<\/a><\/p>\n

Frock, RL, Chen, SC, Da, D., Frett, E., Lau, C., Brown, C., Pak, DN, Wang, Y., Muchir, A., Worman, HJ, Santana, LF, Ladiges, WC, Rabinovitch, PS, & Kennedy, BK (2012). \uc2ec\uadfc\uc138\ud3ec \ud2b9\uc774\uc801 \ub77c\ubbfc A \ubc1c\ud604\uc740 Lmna-\/- \ub9c8\uc6b0\uc2a4\uc5d0\uc11c \uc2ec\uc7a5 \uae30\ub2a5\uc744 \uac1c\uc120\ud569\ub2c8\ub2e4. \ud50c\ub85c\uc2a4 \uc6d0<\/em>, 7<\/em>(8), 1-9. https:\/\/doi.org\/10.1371\/journal.pone.0042918<\/a><\/p>\n

Sullivan, T. (1999). A\ud615 \ub77c\ubbfc \ubc1c\ud604\uc758 \uc190\uc2e4\uc740 \ud575\ub9c9 \ubb34\uacb0\uc131\uc744 \uc190\uc0c1\uc2dc\ucf1c \uadfc\uc774\uc601\uc591\uc2e4\uc870\ub97c \ucd08\ub798\ud569\ub2c8\ub2e4. \uc138\ud3ec\uc0dd\ubb3c\ud559 \uc800\ub110<\/em>, 147<\/em>(5), 913-920. https:\/\/doi.org\/10.1083\/jcb.147.5.913<\/a><\/p>\n

[\/et_pb_toggle][et_pb_toggle title=” To Dr. Giovanna Lattanzi: 2 Questions and Answers for Dr. Lattanzi listed below.” open_toggle_background_color=”#f7f7f7″ closed_toggle_text_color=”#ffffff” closed_toggle_background_color=”#00b2e2″ icon_color=”#ffc15e” open_icon_color=”#ffc15e” admin_label=”Lattanzi Q&A 2″ _builder_version=”4.16″ _module_preset=”default” title_text_color=”#00b2e2″ title_font=”||||||||” background_color=”#ffffff” custom_margin=”||25px” custom_padding=”|50px||50px||true” border_width_all=”0px” global_colors_info=”{}”]<\/p>\n

\"\"\uc9c8\ubb38:<\/span> <\/strong>\ud1b0 \ubbf8\uc2a4\ud154\ub9ac\uc758 \ub9d0: \ub3d9\ubb3c\uc5d0\uac8c \ub85c\ub098\ud30c\ub2d9 + \ud1a0\uc9c8\ub9ac\uc8fc\ub9d9\uc744 \ud22c\uc5ec\ud55c \uae30\uac04\uc740 \uc5bc\ub9c8\ub098 \ub418\uc5c8\ub098\uc694?
\ub2f5\ubcc0:<\/span> <\/strong>\uc6b0\ub9ac\ub294 22\uc8fc\ucc28\ubd80\ud130 30\uc8fc\ucc28\uae4c\uc9c0 \uc774\ud615 \uc811\ud569 \ub3d9\ubb3c\uc5d0\uc11c \uc608\ube44 \uc2e4\ud5d8\uc744 \uc218\ud589\ud588\uc2b5\ub2c8\ub2e4. \uc6b0\ub9ac\ub294 \uc774\uc804\uc5d0 \ud1a0\uc2e4\ub9ac\uc8fc\ub9d9\uc73c\ub85c \uad00\ucc30\ub41c \uccb4\uc911 \uc99d\uac00\uc5d0 \ub300\ud55c \ud6a8\uacfc\ub97c \ud3c9\uac00\ud558\uae30 \uc704\ud574 \uc774 \uae30\uac04 \ub3d9\uc548 \uc9d1\uc911\ud558\uace0\uc790 \ud569\ub2c8\ub2e4.<\/p>\n

\uc9c8\ubb38: <\/strong><\/span>Sgonzalo\ub85c\ubd80\ud130: \uc544\ub984\ub2e4\uc6b4 \uc774\uc57c\uae30 Giovanna\uc640 Sammy!!! tocilizumab \uce58\ub8cc\uc758 \ubd80\uc791\uc6a9\uc744 \ubcf4\uc168\ub098\uc694? \uc544\ub2c8\uba74 progeria \ub9c8\uc6b0\uc2a4\uc5d0\uc11c \uac1c\uc120\ub418\uc9c0 \uc54a\uc740 \ud45c\ud604\ud615\uc774 \uc788\ub098\uc694? Giovanna Lattanzi \ubc15\uc0ac\uc5d0\uac8c: \uc9c8\ubb38: tom misteli\ub85c\ubd80\ud130: \ub3d9\ubb3c\uc5d0\uc11c lonafarnib + tozilizumab \uce58\ub8cc\ub294 \uc5bc\ub9c8\ub098 \uc624\ub798 \uc9c4\ud589\ub418\uc5c8\ub098\uc694?
\ub2f5\ubcc0: <\/strong><\/span>\uc218\uc790\ub098, \uace0\ub9d9\uc2b5\ub2c8\ub2e4. \uc544\ub2c8\uc694, \ud1a0\uc2e4\ub9ac\uc8fc\ub9d9\uc758 \ubd80\uc791\uc6a9\uc740 \ubcf4\uc774\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4. \uac80\uc0ac\ud55c \ud45c\ud604\ud615(\ucc99\ucd94\ud6c4\ub9cc\uc99d, \uc9c0\ubc29\uc870\uc9c1 \uc774\uc0c1\uc99d, \ubaa8\ubc1c \ubc0f \ud53c\ubd80 \uacb0\ud568, \uc6b4\ub3d9 \ud65c\ub3d9, \ub300\ub3d9\ub9e5 \ubcd1\ubcc0 \ubc0f \uc2ec\uadfc \ube44\ub300\uc99d) \uc911\uc5d0\uc11c \uc9c0\uc5f0\/\uac1c\uc120\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n

\ub17c\ud3c9: <\/strong><\/span>MARIE GERHARD-HERMAN\uc758 \uc800\uc11c: \ubbf8\uad6d\uc5d0\uc11c\ub3c4 \ub958\ub9c8\ud2f0\uc2a4 \uc9c8\ud658 \ubc0f \ud608\uad00\uc5fc\uc5d0 \uc0ac\uc6a9\ub428
\ud68c\uc2e0\ud558\ub2e4:<\/span> <\/strong>\ud608\uad00\uc5fc \uce58\ub8cc\uc5d0 \uad00\ud55c \ud765\ubbf8\ub85c\uc6b4 \uc815\ubcf4\ub97c \uc54c\ub824\uc8fc\uc154\uc11c \uac10\uc0ac\ud569\ub2c8\ub2e4, Marie.<\/p>\n

\ub17c\ud3c9:<\/span> <\/strong>pc stefano\uc5d0\uc11c: Tocilizumab\uc740 \uba74\uc5ed \uc5b5\uc81c \ud6a8\uacfc \uc5c6\uc774 Castleman \uc9c8\ubcd1\uc744 \uce58\ub8cc\ud558\uae30 \uc704\ud574 \uc77c\ubcf8\uc5d0\uc11c\ub3c4 \uc2b9\uc778\ub418\uc5c8\uc2b5\ub2c8\ub2e4.
\ud68c\uc2e0\ud558\ub2e4: <\/strong><\/span>\uc774 \uc815\ubcf4\ub97c \uc54c\ub824\uc8fc\uc154\uc11c \uac10\uc0ac\ud569\ub2c8\ub2e4, \uc2a4\ud14c\ud30c\ub178.<\/p>\n

[\/et_pb_toggle][et_pb_toggle title=”To Dr. Minju Kim and Somi Kang who presented on behalf of Dr. Bum-Joon Park: 8 Questions and Answers for Dr. Minju Kim and Somi Kanglisted below.” open_toggle_background_color=”#f7f7f7″ closed_toggle_text_color=”#ffffff” closed_toggle_background_color=”#00b2e2″ icon_color=”#ffc15e” open_icon_color=”#ffc15e” admin_label=”Kim and Kang Q&A 6 questions” _builder_version=”4.16″ _module_preset=”default” title_text_color=”#00b2e2″ title_font=”||||||||” background_color=”#ffffff” custom_margin=”||25px” custom_padding=”|50px||50px||true” border_width_all=”0px” global_colors_info=”{}”]<\/p>\n

\"\"\"\" <\/strong><\/p>\n

\uc9c8\ubb38:<\/span> <\/strong>Delphine Larrieu: HGPS \uc138\ud3ec\/HGPS \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc5d0\uc11c \ud504\ub85c\uac8c\ub9ac\ub2cc \uce58\ub8cc\ub97c \ud558\uba74 DNA \uc190\uc0c1\uc774 \uac10\uc18c\ud558\ub294 \uac83\uc744 \ubcf4\uc2ed\ub2c8\uae4c?
\ub2f5\ubcc0: <\/strong><\/span>\uc6b0\ub9ac\ub294 \ud504\ub85c\uac8c\ub9ac\ub2cc \uce58\ub8cc \ud6c4\uc5d0 DNA \ubcf5\uad6c \uad00\ub828 \uc720\uc804\uc790(BRCA1, Rad51 \ub4f1)\uac00 \ubcc0\ud654\ub418\ub294 \uac83\uc744 \uad00\ucc30\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc9c8\ubb38:<\/strong> <\/span>Delphine Larrieu\uc758 \uae00: \ud504\ub85c\uac8c\ub9ac\ub2cc\uc740 \ubca0\ub974\ub108\uc5d0\uc11c \uc5b4\ub5bb\uac8c \uc791\ub3d9\ud569\ub2c8\uae4c?
\uc81c\uac00 \uc544\ub294 \ud55c \ud504\ub85c\uac8c\ub9b0\uc744 \ubc1c\ud604\ud558\uc9c0 \uc54a\ub294 \uc99d\ud6c4\uad70? \ubd84\uc790\uc5d0 \ub2e4\ub978 \ud45c\uc801\uc774 \uc788\ub098\uc694?
\ub2f5\ubcc0: <\/strong><\/span>WS \uc138\ud3ec\ub294 \ub610\ud55c \uc815\uc0c1\uc801\uc778 \ub178\ud654\uc640 \ub9c8\ucc2c\uac00\uc9c0\ub85c \uc18c\ub7c9\uc758 \ud504\ub85c\uac8c\ub9b0\uc744 \uc0dd\uc131\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.
\uc138\ud3ec. \uc6b0\ub9ac\ub294 mRNA \uc218\uc900\uc5d0\uc11c WS \uc138\ud3ec\uc5d0\uc11c \ud504\ub85c\uac8c\ub9b0 \ubc1c\ud604\uc744 \uad00\ucc30\ud588\uc2b5\ub2c8\ub2e4.
\uc6b0\ub9ac\ub294 WRN \ub2e8\ubc31\uc9c8\uc774 \ud504\ub85c\uac8c\ub9b0\uc744 \uc5b5\uc81c\ud558\ub294 \uae30\ub2a5\uc744 \ud560 \uc218 \uc788\ub2e4\uace0 \uc0dd\uac01\ud569\ub2c8\ub2e4. \uadf8\ub7ec\ub098
WS \ud658\uc790\uc758 \uacbd\uc6b0 WRN \ub2e8\ubc31\uc9c8\uc774 \uc5c6\uae30 \ub54c\ubb38\uc5d0 \ud504\ub85c\uac8c\ub9b0 \ubc1c\ud604\uc740
\uc815\uc0c1 \uc5f0\ub839\ub300\uc5d0\uc11c \ub098\ud0c0\ub098\ub294 \ub9cc\ud07c 20\ub300\uc640 30\ub300\uc5d0\ub3c4 \ub098\ud0c0\ub0a0 \uac83\uc73c\ub85c \uc0dd\uac01\ub41c\ub2e4.
\uc0ac\ub78c\ub4e4.<\/p>\n

\uc9c8\ubb38: <\/strong><\/span>Bob Bishop\uc758 \uae00: \ud504\ub85c\uac8c\ub9ac\ub2cc \uacb0\ud569 \ubd80\uc704\ub294 \uc0dd\ud654\ud559\uc801\uc73c\ub85c \uc815\uc758\ub418\uc5b4 \uc788\uc2b5\ub2c8\uae4c?
\uad6c\uc870\uc801\uc73c\ub85c? \ucd94\uac00 \ud654\ud569\ubb3c\uc744 \ucc3e\uae30 \uc704\ud55c \uc0dd\ud654\ud559\uc801 \ubd84\uc11d\uc774 \uc788\uc2b5\ub2c8\uae4c?
\uc774\ub7f0 \uba54\ucee4\ub2c8\uc998\uc73c\ub85c?
\ub2f5\ubcc0: <\/strong><\/span>\uc6b0\ub9ac\ub294 \ubc14\uc774\uc624\ud2f4-\uc544\ube44\ub518 \ube44\ub4dc \ud480\ub2e4\uc6b4 \ubd84\uc11d\uc744 \uc218\ud589\ud558\uc5ec \uad00\ucc30\ud588\uc2b5\ub2c8\ub2e4.
\ud398\ub85c\uac8c\ub9ac\ub2cc\uacfc \ud504\ub85c\uac8c\ub9b0\uc758 \ud2b9\uc815 \uc0c1\ud638\uc791\uc6a9\uc740 \ub77c\ubbfc A, \ub77c\ubbfc\uacfc\ub294 \uc0c1\ud638\uc791\uc6a9\uc774 \uc544\ub2d8
B, p53, \ub610\ub294 \uc5d0\uba54\ub9b0.
\ub610\ud55c \uc6b0\ub9ac\ub294 \ucd94\uac00\uc801\uc778 \ud654\ud569\ubb3c\uc744 \ucc3e\uae30 \uc704\ud574 Elisa \ubd84\uc11d\ub3c4 \uc218\ud589\ud588\uc2b5\ub2c8\ub2e4.
\ucd94\uc815\ub418\ub294 \ud504\ub85c\uac8c\ub9b0\/\ub77c\ubbfc A \uacb0\ud569 \uc5b5\uc81c\uc81c\uac00 \ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ud504\ub85c\uac8c\ub9b0 \uc7ac\uc870\ud569 \ub2e8\ubc31\uc9c8\uc740 \ud654\ud559 \ub77c\uc774\ube0c\ub7ec\ub9ac\uc640 \ub77c\ubbfc A\uc640 \uc21c\ucc28\uc801\uc73c\ub85c \ubc30\uc591\ub418\uc5c8\uc2b5\ub2c8\ub2e4.
\uadf8\ub7ec\ub098 \ud504\ub85c\uac8c\ub9ac\ub2cc\uc740 \ud654\ud559 \ubb3c\uc9c8 \uc911 \uac00\uc7a5 \ud6a8\uacfc\uc801\uc778 \ud654\ud559 \ubb3c\uc9c8\uc774\uc5c8\uc2b5\ub2c8\ub2e4.
\ub3c4\uc11c\uad00.\"\"<\/p>\n

\"\"<\/p>\n

\uc9c8\ubb38: <\/strong><\/span>John Cooke\uc758 \uae00: \ud070 \uc9c4\uc804\uc785\ub2c8\ub2e4, \uae40 \ubc15\uc0ac\ub2d8. \ud504\ub85c\uac8c\ub9ac\ub2cc\uc774
SASP \uc0ac\uc774\ud1a0\uce74\uc778 \ubd84\ube44?
\ub2f5\ubcc0: <\/strong><\/span>\uc6b0\ub9ac\ub294 \ud504\ub85c\uac8c\ub9ac\ub2cc\uc774 IL6 \ubc0f IL8\uc758 \ubc1c\ud604\uc744 \uac10\uc18c\uc2dc\ud0ac \uc218 \uc788\ub2e4\ub294 \uac83\uc744 \uad00\ucc30\ud588\uc2b5\ub2c8\ub2e4.
HGPS \uc138\ud3ec.<\/p>\n

\uc9c8\ubb38: <\/strong><\/span>\uc218\uc794 \ubbf8\uce74\uc5d8\ub9ac\uc2a4\uc758 \ub9d0: \uc5f0\uad6c\uc790\ub4e4\uc774 \ud504\ub85c\uac8c\ub9ac\ub2cc\uc744 \uc774\uc6a9\ud560 \uc218 \uc788\uc744\uae4c\uc694?
\ub2f5\ubcc0: <\/strong><\/span>\ubb3c\ub860, \uc694\uccad\ud558\uc2dc\uba74 \uc81c\uacf5 \uac00\ub2a5\ud569\ub2c8\ub2e4.<\/p>\n

\uc9c8\ubb38: <\/strong><\/span>Thomas W Glover\uc758 \uae00: \ub0b4\uac00 \ub193\uce5c \uac83\uc77c \uc218\ub3c4 \uc788\uc9c0\ub9cc \ub2f9\uc2e0\uc740 \ubb34\uc5c7\uc774\ub77c\uace0 \uc0dd\uac01\ud558\uc2ed\ub2c8\uae4c?
\ubca0\ub974\ub108 \uc99d\ud6c4\uad70\uc5d0 \uc720\uc775\ud55c \ud6a8\uacfc\ub97c \uc8fc\ub294 \uba54\ucee4\ub2c8\uc998\uc740 \ubb34\uc5c7\uc785\ub2c8\uae4c?
\ub2f5\ubcc0: <\/strong><\/span>WS \ud658\uc790 \uc720\ub798 \uc138\ud3ec\ub294 \ub610\ud55c \uc18c\ub7c9\uc758 \ud504\ub85c\uac8c\ub9b0\uc744 \uc0dd\uc131\ud569\ub2c8\ub2e4.
\ub178\ub839\uc790\ub85c\ubd80\ud130 \uc720\ub798\ub41c \uc815\uc0c1 \uc138\ud3ec\uc640 \ub9e4\uc6b0 \uc720\uc0ac\ud569\ub2c8\ub2e4. \ud504\ub85c\uac8c\ub9ac\ub2cc\uc740 \ub610\ud55c
\ud504\ub85c\uac8c\ub9b0 \ubc1c\ud604\uc744 \uac10\uc18c\uc2dc\ucf1c WS \uc138\ud3ec\uc5d0\uc11c \ud6a8\uacfc\uc801\uc785\ub2c8\ub2e4.<\/p>\n

[\/et_pb_toggle][et_pb_toggle title=”To Dr. Martin Berg\u00f6: Question: From Mario D. Cordero: Have you studied the effect about inflammation?” open_toggle_background_color=”#f7f7f7″ closed_toggle_text_color=”#ffffff” closed_toggle_background_color=”#00b2e2″ icon_color=”#ffc15e” open_icon_color=”#ffc15e” admin_label=”Dr. Martin Berg\u00f6” _builder_version=”4.16″ _module_preset=”default” title_text_color=”#00b2e2″ title_font=”||||||||” background_color=”#ffffff” custom_margin=”||25px” custom_padding=”|50px||50px||true” border_width_all=”0px” global_colors_info=”{}”]<\/p>\n

\"\"\ub2f5\ubcc0: <\/strong>\uc9c8\ubb38 \uac10\uc0ac\ud569\ub2c8\ub2e4: \uc544\ub2c8\uc694, \uc5fc\uc99d \uc790\uccb4\ub294 \uc544\ub2d9\ub2c8\ub2e4. \uc5fc\uc99d\uacfc \ubd80\ubd84\uc801\uc73c\ub85c \uad00\ub828\uc774 \uc788\uc73c\uba70, \uc774 \ud504\ub85c\uc81d\ud2b8\uc5d0\uc11c \ub300\uc2dd\uc138\ud3ec\ub97c \uc5f0\uad6c\ud588\uace0 \ub179\uc544\uc6c3\u00a0\uc544\uc774\uc528\uc5e0\ud2f0<\/i>\u00a0\ub300\uc2dd\uc138\ud3ec \ucf5c\ub808\uc2a4\ud14c\ub864 \uc720\ucd9c\uc744 \uc99d\uac00\uc2dc\ud0a4\uace0, \uae30\uc800 \ubc0f ApoAI \ubc0f HDL \uc790\uadf9 \ubaa8\ub450\uc5d0\uc11c. \uc774 \ud6a8\uacfc\ub294 \ub54c\ub54c\ub85c \uc0dd\uccb4 \ub0b4 \uc5ed \ucf5c\ub808\uc2a4\ud14c\ub864 \uc218\uc1a1 \uc99d\uac00\uc640 \uad00\ub828\uc774 \uc788\uc73c\ubbc0\ub85c, \uc6b0\ub9ac\ub294 \ub2e4\uc74c\uc744 \uacb0\uc815\ud558\uace0\uc790 \ud569\ub2c8\ub2e4.\u00a0\uc544\uc774\uc528\uc5e0\ud2f0<\/i>\u00a0\uc5b5\uc81c\ud558\uba74 \uc8fd\uc0c1\uacbd\ud654\uc99d \ubc1c\ubcd1\uc774 \uac10\uc18c\ud569\ub2c8\ub2e4.<\/p>\n

[\/et_pb_toggle][et_pb_toggle title=”To Dr. David Liu: Question: 3 Questions and Answers for Dr. Lui listed below.” open_toggle_background_color=”#f7f7f7″ closed_toggle_text_color=”#ffffff” closed_toggle_background_color=”#00b2e2″ icon_color=”#ffc15e” open_icon_color=”#ffc15e” admin_label=”Dr. David Liu Q&A 3″ _builder_version=”4.16″ _module_preset=”default” title_text_color=”#00b2e2″ title_font=”||||||||” background_color=”#ffffff” custom_margin=”||25px” custom_padding=”|50px||50px||true” border_width_all=”0px” global_colors_info=”{}”]<\/p>\n

\"\"<\/p>\n

\uc9c8\ubb38: <\/strong><\/span>vandres\ub2d8\uaed8: \ub2e4\uc591\ud55c \uc5f0\ub839\ub300\uc758 \uc778\uac04 HGPS \uc12c\uc720\uc544\uc138\ud3ec\uc5d0\uc11c DNA \uad50\uc815\uc744 \uc2dc\ub3c4\ud574 \ubcf4\uc168\ub098\uc694? (\uc2dc\ud5d8\uad00 \ub0b4) \uadf8\ub9ac\uace0 \uc138\ud3ec\uac00 \ub178\ud654\ub428\uc5d0 \ub530\ub77c \ud45c\ud604\ud615\uc774 \uac10\uc18c\ud558\ub294\uc9c0 \ud655\uc778\ud558\uae30 \uc704\ud574 \uc815\uc0c1\ud654\ub418\ub294\uc9c0\ub3c4 \ud14c\uc2a4\ud2b8\ud574 \ubcf4\uc168\ub098\uc694?
\ub2f5\ubcc0:<\/span> <\/strong>\uc544\ub2c8\uc694, \uc6b0\ub9ac\ub294 \uc11c\ub85c \ub2e4\ub978 \uc5ec\ub7ec \uc5f0\ub839\ub300\uc758 \ud658\uc790\uc758 \uc12c\uc720\uc544\uc138\ud3ec\ub97c \uad50\uc815\ud558\ub294 \uac83\uc744 \uc2dc\ub3c4\ud558\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4. \ub450 \uba85\uc758 \ub2e4\ub978 \ud658\uc790\ub97c \ub300\uc0c1\uc73c\ub85c\ub9cc \uad50\uc815\uc744 \uc2dc\ub3c4\ud588\uace0, \uadf8 \uacb0\uacfc\ub294 \ube44\uc2b7\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc9c8\ubb38:<\/strong> <\/span>\ub378\ud540 \ub77c\ub9ac\uc6b0\uc758 \uae00: \ub180\ub77c\uc6b4 \ud6a8\uacfc! \uc774\ud615\uc811\ud569 \ub9c8\uc6b0\uc2a4\uc5d0\uc11c \ud504\ub85c\uac8c\ub9b0\uc774 \uc644\uc804\ud788 KO\ub418\ub294 \uac78 \uae30\ub300\ud558\uc2dc\ub098\uc694?
\ub2f5\ubcc0:<\/span> <\/strong>\ub2e8\uc77c \uc0ac\ubcf8 \ub9c8\uc6b0\uc2a4\uc758 \uacbd\uc6b0 \ud604\uc7ac \uad00\ucc30\ub418\ub294 \uac83\uacfc \ud06c\uac8c \ub2e4\ub978 \ud3b8\uc9d1 \ud6a8\uc728\uc744 \uae30\ub300\ud558\uc9c0\ub294 \uc54a\uc744 \uac83\uc785\ub2c8\ub2e4. \uc65c\ub0d0\ud558\uba74 \uac01 \ud504\ub85c\uac8c\ub9b0\uc5d0 \ub300\ud55c \ud3b8\uc9d1 \uc5d0\uc774\uc804\ud2b8\uac00 \uc774\ubbf8 \uacfc\uc789 \uc0c1\ud0dc\uc774\uae30 \ub54c\ubb38\uc785\ub2c8\ub2e4.<\/p>\n

\uc9c8\ubb38: <\/span><\/strong>\uc548\ub4dc\ub808 \ubaac\ud14c\uc774\ub85c \ub2e4 \ub85c\uc0e4\uc758 \ub9d0: \ub0ae\uc740 \ube44\uc728\uc758 \uc138\ud3ec\ub97c \uc7ac\ud504\ub85c\uadf8\ub798\ubc0d\ud558\uba74 \uc904\uae30\uc138\ud3ec \uae30\ub2a5\uc740 \ubcf5\uad6c\ud560 \uc218 \uc788\uc9c0\ub9cc, \uc131\uccb4 \uc904\uae30\uc138\ud3ec\uac00 \uace0\uac08\ub420 \uc218 \uc788\ub2e4\uace0 \uc0dd\uac01\ud558\uc2ed\ub2c8\uae4c?
\ub2f5\ubcc0:<\/span> <\/strong>\uc774 \uc9c8\ubb38\uc5d0 \ub300\ub2f5\ud560 \uc218 \uc788\ub294 \uc790\ub8cc\uac00 \uc5c6\uc2b5\ub2c8\ub2e4.<\/p>\n

[\/et_pb_toggle][et_pb_toggle title=”To Dr. Colin Stewart: 8 Questions and Answers for Dr. Stewart listed below.” open_toggle_background_color=”#f7f7f7″ closed_toggle_text_color=”#ffffff” closed_toggle_background_color=”#00b2e2″ icon_color=”#ffc15e” open_icon_color=”#ffc15e” admin_label=”Dr. Colin Stewart” _builder_version=”4.16″ _module_preset=”default” title_text_color=”#00b2e2″ title_font=”||||||||” background_color=”#ffffff” custom_margin=”||25px” custom_padding=”|50px||50px||true” border_width_all=”0px” global_colors_info=”{}”]<\/p>\n

\"\"\uc9c8\ubb38:<\/strong><\/span> \uba54\uc774\uc758 \ub9d0: \uc2ec\uadfc\uc138\ud3ec \uac19\ub124\uc694. \uc5fc\uc0c9\uc774 \ucc38 \uc608\uc058\ub124\uc694!
Abby Buchwalter\uc758 \uae00: \uc6b0\uc131\uc801 \uc74c\uc131 Sun1 \ubc1c\ud604\uc774 Sun2\ub97c \ud3ec\ud568\ud55c \ubaa8\ub4e0 LINC \ubcf5\ud569\uccb4\ub97c \ubc29\ud574\ud569\ub2c8\uae4c?
\ub2f5\ubcc0:<\/span> <\/strong>\ub124, NE\uc758 \ubaa8\ub4e0 Nesprin\uc774 DNSUN1\uc5d0 \uc758\ud574 \ub300\uccb4\ub420 \uc218 \uc788\ub2e4\ub294 \uc2dc\ud5d8\uad00 \ub0b4 \uc99d\uac70\uac00 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc9c8\ubb38:<\/strong><\/span> Suet Nee Chen\uc758 \ub2f5\ubcc0: AAV9-SunDn\uc774 \uc7a5\uae30\uc801\uc778 \ud6a8\uacfc\ub97c \ub098\ud0c0\ub0bc \uc218 \uc788\ub294 \uba54\ucee4\ub2c8\uc998\uc740 \ubb34\uc5c7\uc774\uace0 \uc5b4\ub5bb\uac8c \uac00\ub2a5\ud569\ub2c8\uae4c? LMNA \ub3cc\uc5f0\ubcc0\uc774 \ub9c8\uc6b0\uc2a4\uc5d0 AAV9-Sun1DN\uc744 \uba87 \uc0b4 \ub54c \uc8fc\uc0ac\ud588\uc2b5\ub2c8\uae4c?
\ub2f5\ubcc0:<\/span> <\/strong>\uc6b0\ub9ac\ub294 Cre \uc7ac\uc870\ud569\ud6a8\uc18c\uac00 \ub77c\ubbfcA\ub97c \uc0ad\uc81c\ud558\ub3c4\ub85d \uc720\ub3c4\ud55c \uc9c0 \ud558\ub8e8 \ud6c4\uc5d0 DNSUN1 AAV\ub97c \uc8fc\uc785\ud588\uc2b5\ub2c8\ub2e4. \uc6b0\ub9ac\ub294 AAV\uac00 \uc804\ub2ec\ud55c DNSUN1\uc774 \uc8fc\uc785 \ud6c4 1\ub144 \ud6c4\uc5d0\ub3c4 \uc2ec\uadfc\uc138\ud3ec\uc5d0\uc11c \uacc4\uc18d \ubc1c\ud604\ub41c\ub2e4\ub294 \ub370\uc774\ud130\ub97c \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc6b0\ub9ac\ub294 \uc2e4\ud5d8\uc2e4\ub85c \ub3cc\uc544\uc640\uc11c \ucda9\ubd84\ud55c \uc591\uc758 AAV\ub97c \uc9c1\uc811 \ub9cc\ub4e4 \uc218 \uc788\uac8c \ub418\uc5b4\uc11c \uc6a9\ub7c9\/\ud0c0\uc774\ubc0d\/\ubc18\uc751 \uc2e4\ud5d8\uc744 \ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc9c8\ubb38:<\/span><\/strong> Martin Berg\u00f6, Viceordf\u00f6rande Kommitt\u00e9n f\u00f6r forskning: Lmna \ub179\uc544\uc6c3 \uc2e4\ud5d8\uc5d0\uc11c \ub77c\ubbfc A\uac00 \uc5c6\ub294 \uacbd\uc6b0\uc640 \ub77c\ubbfc C\uac00 \uc0c1\ub300\uc801\uc73c\ub85c \uc5b4\ub5bb\uac8c \uae30\uc5ec\ud55c\ub2e4\uace0 \uc0dd\uac01\ud558\uc2ed\ub2c8\uae4c?
\ub2f5\ubcc0:<\/strong><\/span> \uc774\uac83\uc5d0 \ub300\ud574\uc11c\ub294 \ud655\uc2e4\ud558\uc9c0 \uc54a\uc9c0\ub9cc Sun1\uc740 LaminA\uc640 \uc0c1\ud638 \uc791\uc6a9\ud558\uba70 HGPS \ub9c8\uc6b0\uc2a4\uc5d0\uc11c\ub294 \ubaa8\ub4e0 LaminA(\ud504\ub85c\uac8c\ub9b0\uc774 \uc720\ub798\ub428)\uac00 \uae30\uc5ec\ud574\uc57c \ud569\ub2c8\ub2e4.<\/p>\n

\uc9c8\ubb38:<\/span><\/strong> jcampisi\uc758 \uae00: SUN1 KO \ub610\ub294 hets\uc758 \uc0ac\ub9dd \uc6d0\uc778\uc740 \ubb34\uc5c7\uc785\ub2c8\uae4c?
\ub2f5\ubcc0:<\/strong><\/span> \uc88b\uc740 \uc9c8\ubb38\uc785\ub2c8\ub2e4. \uc6b0\ub9ac\ub294 \uc544\uc9c1 \ubaa8\ub974\uc9c0\ub9cc \ud604\uc7ac \uba87\uba87 \uace8\uaca9\uadfc \uadf8\ub8f9\uc744 \uc758\uc2ec\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc8fd\uc5b4\uac00\ub294 \uc950\uc5d0 \ub300\ud55c \uc801\uc808\ud55c \uc870\uc9c1\ubcd1\ub9ac\ud559\uc801 \ubd84\uc11d\uc744 \ud574\uc57c \ud569\ub2c8\ub2e4.<\/p>\n

\uc9c8\ubb38: <\/span><\/strong>\ud1b0 \ubbf8\uc2a4\ud154\ub9ac\uc758 \ub9d0: \ucf5c\ub9b0: Lmna\/Sun \ub3d9\ubb3c\uc5d0\uc11c \uc138\ud3ec \uc2a4\ud2b8\ub808\uc2a4 \ubc18\uc751 \uacbd\ub85c\uc758 \ubcc0\ud654\ub97c \ubcf4\uc168\ub098\uc694?
\ub2f5\ubcc0:<\/strong><\/span> \uc6b0\ub9ac\ub294 \uc544\uc9c1 \uc774\ub4e4 \ub9c8\uc6b0\uc2a4\uc5d0\uc11c \uc2a4\ud2b8\ub808\uc2a4 \ubc18\uc751 \uc720\uc804\uc790\/\ub9c8\ucee4\ub97c \uce21\uc815\ud558\uc9c0 \ubabb\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc9c8\ubb38: \ub378\ud540 \ub77c\ub9ac\uc6b0\uc758 \ub2f5\ubcc0: HGPS \ud658\uc790\uc5d0\uc11c DNSUN1\uc744 \ud1b5\ud574 \uc2ec\uc7a5\ub9cc\uc744 \ud45c\uc801\uc73c\ub85c \uc0bc\uc744 \uc218 \uc788\uc744 \uac83\uc73c\ub85c \uc0dd\uac01\ud558\uc2dc\ub098\uc694?
\ub2f5\ubcc0:<\/strong><\/span> \ud608\uccad\ud615\uacfc \uc2ec\uadfc\uc138\ud3ec \ud2b9\uc774\uc801 \ud504\ub85c\ubaa8\ud130\uc758 \uc0ac\uc6a9\uc744 \uac10\uc548\ud558\uba74 \uac00\ub2a5\ud569\ub2c8\ub2e4. \ud604\uc7ac \uc774\ub7ec\ud55c \uc2e4\ud5d8\uc774 \uc9c4\ud589 \uc911\uc785\ub2c8\ub2e4.<\/p>\n

\uc9c8\ubb38:<\/span><\/strong>\uc6e8\uc2dc\uc544 \uc655\uc758 \ub9d0: KO SUN1\uc774 \ub3d9\ud615 \uc811\ud569\uccb4 G609G \ub9c8\uc6b0\uc2a4\uc5d0\uc11c \uc65c \ud6a8\uacfc\uac00 \uc801\uc740\uac00?
\ub2f5\ubcc0:<\/strong><\/span> \uc544\ub9c8\ub3c4 \ub3d9\ud615\uc811\ud569\uccb4 \ub9c8\uc6b0\uc2a4\uac00 \ub354 \ub9ce\uc740 \ud504\ub85c\uac8c\ub9b0\uc744 \ubc1c\ud604\ud558\uae30 \ub54c\ubb38\uc77c \uac83\uc785\ub2c8\ub2e4. \uc6b0\ub9ac\ub294 \uc720\uc804 \uc2e4\ud5d8\uc5d0\uc11c \uc774\ud615\uc811\ud569\uccb4 \ub300 \ub3d9\ud615\uc811\ud569\uccb4\uc758 \ubc18\uc751 \ud6a8\uacfc\ub97c \ubd05\ub2c8\ub2e4.<\/p>\n

\uc9c8\ubb38:<\/span><\/strong>Roland Foisner\uc758 \uae00: \uc548\ub155\ud558\uc138\uc694, Colin, \uc88b\uc740 \uc774\uc57c\uae30\uc600\uc2b5\ub2c8\ub2e4. HGPS\uc5d0\uc11c \uc0c1\ud5a5 \uc870\uc808\ub41c SUN1\uc758 \ubd80\uc815\uc801 \uc601\ud5a5\uc740 \ubb34\uc5c7\uc785\ub2c8\uae4c? Roland
\ub2f5\ubcc0:<\/strong><\/span> \uc544\ub9c8\ub3c4 MT \ub124\ud2b8\uc6cc\ud06c\uc640 LINC \ubcf5\ud569\uccb4\uc758 \uc5f0\uad00\uc131\uc774 \uc99d\uac00\ud588\uc744 \uac83\uc785\ub2c8\ub2e4. \ubc30\uc591 \uc138\ud3ec\uc5d0\uc11c Sun\/Nesprin \ubc1c\ud604\uc774 \uc99d\uac00\ud558\uba74 \ud575 \uc704\uce58\uc640 \uc138\ud3ec \uc774\ub3d9\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce69\ub2c8\ub2e4.<\/p>\n

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Basso\uc640 Peraut \uac00\uc871\uc744 \ub9cc\ub098\uc11c \uc601\uad11\uc785\ub2c8\ub2e4. \uc5ec\ub7ec\ubd84\uc758 \uc5ec\uc815\uc744 \uacf5\uc720\ud574 \uc8fc\uc154\uc11c \uac10\uc0ac\ud569\ub2c8\ub2e4. \uc5ec\ub7ec\ubd84\uc740 \uc815\ub9d0 \uc601\uac10\uc774 \ub418\uc2ed\ub2c8\ub2e4!<\/p>\n

\uc6cc\ud06c\uc20d\uc5d0 \ucc38\uc5ec\ud574 \uc8fc\uc2dc\uace0, \ud504\ub85c\uac8c\ub9ac\uc544\uc5d0 \ub300\ud55c \uc601\uac10 \uc5b4\ub9b0 \uc5ec\uc815\uc744 \uacf5\uc720\ud574 \uc8fc\uc2e0 \uc0ac\ubbf8\uc640 \uc54c\ub809\uc0b0\ub4dc\ub77c\uc758 \uac00\uc871\uc5d0\uac8c \uac10\uc0ac\ub4dc\ub9bd\ub2c8\ub2e4!<\/p>\n

\uc544\uc774\uac70\uc758 \ud658\uc0c1\uc801\uc778 \uc9c4\uc804\uc774 \uace7 \uc2b9\uc778\ub420 \ub4ef\ud569\ub2c8\ub2e4.<\/p>\n

\uc774 \uc138\uc158\uc744 \uc8fc\ub9d0\uae4c\uc9c0 \uc5f0\uc7a5\ud574\uc11c \ud1a0\ub860\uc744 \uacc4\uc18d\ud560 \uc218 \uc788\uc744\uae4c\uc694? (\ubaa8\ub450\ub4e4 \uac10\uc0ac\ud569\ub2c8\ub2e4!)\u00a0<\/p>\n

\uc774 \uc6cc\ud06c\uc20d\uc740 \uc815\ub9d0 \ub300\ub2e8\ud588\uc2b5\ub2c8\ub2e4. \uc774 \ud6cc\ub96d\ud55c \ud65c\ub3d9\uc744 \ud558\uae30\ub85c \ud55c PRF\uc758 \ud5cc\uc2e0\uc5d0 \ucd95\ud558\ub97c \uc804\ud569\ub2c8\ub2e4. \uc758\uc2ec\ud560 \uc5ec\uc9c0 \uc5c6\uc774 \uc774 \uc6cc\ud06c\uc20d\uc740 \uc81c \ubbf8\ub798\uc5d0 \ub300\ud55c \ub9ce\uc740 \uc9c0\uc2dd\uc744 \ucc44\uc6cc\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4. \uc815\ub9d0 \ub300\ub2e8\ud588\uc2b5\ub2c8\ub2e4. \ud568\uaed8 \uce58\ub8cc\ubc95\uc744 \ucc3e\uc744 \uac83\uc785\ub2c8\ub2e4!<\/p>\n

PRF \ud68c\uc758\uc5d0\uc11c \ud765\ubbf8\ub85c\uc6b4 \uacfc\ud559\uc5d0 \ud56d\uc0c1 \uac10\uba85\uc744 \ubc1b\uc558\uc2b5\ub2c8\ub2e4. \uc774 \uac00\uc0c1 \ud615\uc2dd\uc5d0\uc11c\ub3c4 \ucee4\ubba4\ub2c8\ud2f0 \uc6cc\ud06c\uc20d \uacbd\ud5d8\uc744 \ubcf4\uc874\ud55c \uc8fc\ucd5c\uc790\uc5d0\uac8c \ub9ce\uc740 \ucc2c\uc0ac\ub97c \ubcf4\ub0c5\ub2c8\ub2e4!<\/p>\n

\uc5ec\ub7ec\ubd84 \ubaa8\ub450 \ud6cc\ub96d\ud574\uc694!!! \uc774 \uc88b\uc740 \uae30\ud68c\ub97c \uc8fc\uc154\uc11c \uac10\uc0ac\ud569\ub2c8\ub2e4. \uba87 \ub144 \uc804\uc744 \uc0dd\uac01\ud558\uba74 \uc9c0\uae08\uc740 \ubbf8\ub798\uc5d0 \uc0ac\ub294 \uac83\uacfc \uac19\uc544\uc694! \ucc38\uc5ec\ud558\uac8c \ub418\uc5b4 \ud589\ubcf5\ud574\uc694<\/p>\n

\ucf5c\ub9b0 \ubc15\uc0ac\uc758 \uae30\ud0c0\uac00 \uadf8\ub9ac\uc6cc\uc694. \uc798\ud558\uc168\uc5b4\uc694!<\/p>\n

\uc774\ub7f0 \uc77c\uc744 \uc8fc\uc120\ud574 \uc8fc\uc154\uc11c \uc815\ub9d0 \uac10\uc0ac\ud569\ub2c8\ub2e4. \uc815\ub9d0 \uc774\ubc88 \uc8fc\uc758 \ud558\uc774\ub77c\uc774\ud2b8\uc600\uc2b5\ub2c8\ub2e4!<\/p>\n

\ubaa8\ub450\ub4e4 \uac10\uc0ac\ub4dc\ub9ac\uace0, \ub0b4\ub144\uc5d0 \ucf00\uc784\ube0c\ub9ac\uc9c0\uc5d0\uc11c \uc9c1\uc811 \ub9cc\ub098\uc694!!<\/p>\n

\u00a0<\/strong>\ud568\uaed8 \ud574\uc8fc\uc2e0 \ubaa8\ub4e0 \ubd84\ub4e4\uaed8 \uac10\uc0ac\ub4dc\ub9bd\ub2c8\ub2e4!<\/strong><\/p>\n

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\uac00\uc785\ud558\uae30<\/h2>\n

\uc6b0\ub9ac\ub97c \uc704\ud574<\/h2>\n

\ud68c\ub78c \uc2e0\ubb38!<\/h2>\n

[\/et_pb_cta][\/et_pb_column][et_pb_column type="1_4" _builder_version="4.16" custom_padding="|||" global_colors_info="{}" custom_padding__hover="|||"][et_pb_cta button_url="https:\/\/progeriaresearch.donorsupport.co\/-\/XZHJVWZR" button_text="\uc9c0\uae08 \uae30\ubd80\ud558\uae30" admin_label="\ud568\uaed8\ub77c\uba74 \uc6b0\ub9ac\ub294 \uce58\ub8cc\ubc95\uc744 \ucc3e\uc744 \uac83\uc785\ub2c8\ub2e4!" module_class="sign-btn" _builder_version="4.16" header_font_size="25px" background_color="#29327a" animation_style="slide" animation_direction="left" animation_intensity_slide="25%" header_font_size_tablet="" header_font_size_phone="30px" header_font_size_last_edited="on|desktop" body_font_size_tablet="" body_font_size_phone="" body_font_size_last_edited="on|desktop" z_index_tablet="500" border_radii="on|25px|25px|25px|25px" global_colors_info="{}" button_bg_color__hover_enabled="on" \ubc84\ud2bc_bg_color__hover="#8fd2ed" \ubc84\ud2bc_\ud14c\ub450\ub9ac_\uc0c9\uc0c1__hover_\ud65c\uc131\ud654="\ucf1c\uc9d0"]<\/p>\n

\uc6b0\ub9ac\ub294 \ud568\uaed8<\/h2>\n

\ud560 \uac83\uc774\ub2e4<\/em><\/h2>\n

\uce58\ub8cc\ubc95\uc744 \ucc3e\uc544\ub77c!<\/h2>\n

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\ud074\ub9bd, \uc0ac\uc9c4, \ub313\uae00, Q&A\ub97c \uc990\uaca8\ubcf4\uc138\uc694!<\/p>","protected":false},"author":2,"featured_media":8394,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[3,2],"tags":[],"class_list":["post-8398","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-events","category-news"],"yoast_head":"\nPRF\u2019s 10th International Scientific Workshop - The Progeria Research Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.progeriaresearch.org\/ko\/2020\/11\/02\/2020-workshop\/\" \/>\n<meta property=\"og:locale\" content=\"ko_KR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PRF\u2019s 10th International Scientific Workshop - 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