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\u092f\u093e\u092e\u0941\u0933\u0947 \u092e\u0941\u0932\u093e\u0902\u0938\u093e\u0920\u0940 \u0906\u0923\u093f \u0906\u092a\u0932\u094d\u092f\u093e \u0938\u0930\u094d\u0935\u093e\u0902\u0938\u093e\u0920\u0940 \u0928\u0935\u0940\u0928 \u0909\u092a\u091a\u093e\u0930\u093e\u0902\u0938\u093e\u0920\u0940 \u0938\u0902\u0915\u0947\u0924 \u092e\u093f\u0933\u0942 \u0936\u0915\u0924\u093e\u0924!<\/p>\n<p>\u0915\u0947\u0902\u0926\u094d\u0930\u0940\u0915\u0943\u0924 \u092c\u093e\u0932\u092a\u0923 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0921\u0947\u091f\u093e\u092c\u0947\u0938 \u0915\u0927\u0940\u0939\u0940 \u0928\u0935\u094d\u0939\u0924\u093e \u091c\u094d\u092f\u093e\u0924\u0942\u0928 \u0906\u0930\u094b\u0917\u094d\u092f \u0938\u0947\u0935\u093e \u092e\u093e\u0939\u093f\u0924\u0940 \u0915\u093e\u0922\u093e\u0935\u0940. \u092f\u093e\u092e\u0941\u0933\u0947 \u0930\u0942\u0917\u094d\u0923\u093e\u0902\u0935\u0930 \u0905\u0928\u093e\u0935\u0927\u093e\u0928\u093e\u0928\u0947 \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u0917\u0948\u0930\u0935\u0930\u094d\u0924\u0928, \u091a\u0941\u0915\u0940\u091a\u0947 \u0928\u093f\u0926\u093e\u0928 \u0906\u0923\u093f \u0909\u0936\u0940\u0930 \u091d\u093e\u0932\u0947\u0932\u094d\u092f\u093e \u0928\u093f\u0926\u093e\u0928\u093e\u0938 \u0915\u093e\u0930\u0923\u0940\u092d\u0942\u0924 \u0920\u0930\u0932\u0947 \u0906\u0939\u0947, \u0915\u093e\u0930\u0923 \u0915\u093e\u0933\u091c\u0940\u0935\u093e\u0939\u0915\u093e\u0902\u0928\u093e \u0939\u0947 \u092e\u093e\u0939\u093f\u0924 \u0928\u0938\u0924\u0947 \u0915\u0940 \u0907\u0924\u0930 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u092e\u0941\u0932\u093e\u0902\u0938\u0939 \u0915\u094b\u0923\u0924\u0940 \u0935\u0948\u0926\u094d\u092f\u0915\u0940\u092f \u0927\u094b\u0930\u0923\u0947 \u092f\u0936\u0938\u094d\u0935\u0940 \u091d\u093e\u0932\u0940 \u0906\u0939\u0947\u0924 \u0906\u0923\u093f \u0915\u094b\u0923\u0924\u094d\u092f\u093e \u0928\u093e\u0939\u0940\u0924. \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0905\u0938\u0932\u0947\u0932\u094d\u092f\u093e \u092e\u0941\u0932\u093e\u0902\u0938\u093e\u0920\u0940 \u0906\u0930\u094b\u0917\u094d\u092f \u0938\u0947\u0935\u093e \u0928\u094b\u0902\u0926\u0940 \u0917\u094b\u0933\u093e \u0915\u0930\u0923\u0947 \u0906\u0923\u093f \u0906\u0930\u094b\u0917\u094d\u092f \u0938\u0947\u0935\u093e \u0935\u094d\u092f\u093e\u0935\u0938\u093e\u092f\u093f\u0915, \u0935\u0948\u0926\u094d\u092f\u0915\u0940\u092f \u0938\u0902\u0936\u094b\u0927\u0915 \u0906\u0923\u093f \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0905\u0938\u0932\u0947\u0932\u094d\u092f\u093e \u092e\u0941\u0932\u093e\u0902\u091a\u0947 \u0915\u0941\u091f\u0941\u0902\u092c \u0935\u093e\u092a\u0930\u0923\u094d\u092f\u093e\u0938\u093e\u0920\u0940 \u0915\u0947\u0902\u0926\u094d\u0930\u0940\u0915\u0943\u0924 \u0906\u0930\u094b\u0917\u094d\u092f \u0921\u0947\u091f\u093e\u092c\u0947\u0938 \u0935\u093f\u0915\u0938\u093f\u0924 \u0915\u0930\u0923\u0947 \u0939\u0947 \u092f\u093e \u092a\u094d\u0930\u0915\u0932\u094d\u092a\u093e\u091a\u0947 \u0909\u0926\u094d\u0926\u093f\u0937\u094d\u091f \u0906\u0939\u0947.<\/p>\n<h4><strong>\u0921\u0947\u091f\u093e\u092c\u0947\u0938\u091a\u0940 \u0909\u0926\u094d\u0926\u093f\u0937\u094d\u091f\u0947<\/strong><\/h4>\n<ul>\n<li>HGPS \u0905\u0938\u0932\u0947\u0932\u094d\u092f\u093e \u092e\u0941\u0932\u093e\u0902\u0928\u093e \u092d\u0947\u0921\u0938\u093e\u0935\u0923\u093e\u0931\u094d\u092f\u093e \u0935\u0948\u0926\u094d\u092f\u0915\u0940\u092f \u0938\u092e\u0938\u094d\u092f\u093e\u0902\u0938\u093e\u0920\u0940 \u0915\u094b\u0923\u0924\u0940 \u0909\u092a\u091a\u093e\u0930 \u092f\u094b\u091c\u0928\u093e \u092f\u0936\u0938\u094d\u0935\u0940 \u091d\u093e\u0932\u0940 \u0906\u0923\u093f \u0915\u094b\u0923\u0924\u0947 \u0909\u092a\u091a\u093e\u0930 \u0905\u092f\u0936\u0938\u094d\u0935\u0940 \u0920\u0930\u0932\u0947 \u092f\u093e\u091a\u0947 \u0924\u092a\u0936\u0940\u0932\u0935\u093e\u0930 \u0935\u0930\u094d\u0923\u0928 \u0915\u0930\u0923\u094d\u092f\u093e\u0938\u093e\u0920\u0940. \u0939\u0947 \u0915\u0941\u091f\u0941\u0902\u092c\u093e\u0902\u0928\u093e \u0906\u0923\u093f \u0924\u094d\u092f\u093e\u0902\u091a\u094d\u092f\u093e \u0921\u0949\u0915\u094d\u091f\u0930\u093e\u0902\u0928\u093e \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0905\u0938\u0932\u0947\u0932\u094d\u092f\u093e \u092e\u0941\u0932\u093e\u0902\u091a\u0940 \u0938\u0930\u094d\u0935\u094b\u0924\u094d\u0924\u092e \u0915\u093e\u0933\u091c\u0940 \u0915\u0936\u0940 \u0918\u094d\u092f\u093e\u0935\u0940 \u0939\u0947 \u0938\u092e\u091c\u0923\u094d\u092f\u093e\u0938 \u092e\u0926\u0924 \u0915\u0930\u0942 \u0936\u0915\u0924\u0947.<\/li>\n<li>HGPS \u0905\u0938\u0932\u0947\u0932\u094d\u092f\u093e \u092e\u0941\u0932\u093e\u0902\u091a\u094d\u092f\u093e \u091c\u0940\u0935\u0928\u093e\u091a\u094d\u092f\u093e \u0917\u0941\u0923\u0935\u0924\u094d\u0924\u0947\u0938\u093e\u0920\u0940 \u092e\u0939\u0924\u094d\u0924\u094d\u0935\u093e\u091a\u094d\u092f\u093e \u0905\u0938\u0932\u0947\u0932\u094d\u092f\u093e \u0938\u092e\u0938\u094d\u092f\u093e\u0902\u092c\u0926\u094d\u0926\u0932 \u0915\u0941\u091f\u0941\u0902\u092c\u093e\u0902\u0928\u093e \u0917\u0948\u0930-\u0935\u0948\u0926\u094d\u092f\u0915\u0940\u092f \u092d\u093e\u0937\u0947\u0924 \u0906\u0930\u094b\u0917\u094d\u092f \u0938\u0947\u0935\u093e \u0936\u093f\u092b\u093e\u0930\u0938\u0940 \u092a\u094d\u0930\u0926\u093e\u0928 \u0915\u0930\u0923\u0947.<\/li>\n<li>\u0921\u0947\u091f\u093e\u092c\u0947\u0938 \u0939\u0947 HGPS \u091a\u094d\u092f\u093e \u0938\u094d\u0935\u0930\u0942\u092a\u093e\u0935\u093f\u0937\u092f\u0940 \u0906\u0923\u093f \u090f\u0925\u0947\u0930\u094b\u0938\u094d\u0915\u094d\u0932\u0947\u0930\u094b\u0938\u093f\u0938 \u0938\u093e\u0930\u0916\u094d\u092f\u093e \u0907\u0924\u0930 \u0930\u094b\u0917\u093e\u0902\u091a\u094d\u092f\u093e \u0938\u094d\u0935\u0930\u0942\u092a\u093e\u092c\u0926\u094d\u0926\u0932 \u0928\u0935\u0940\u0928 \u0905\u0902\u0924\u0930\u094d\u0926\u0943\u0937\u094d\u091f\u0940 \u092a\u094d\u0930\u093e\u092a\u094d\u0924 \u0915\u0930\u0923\u094d\u092f\u093e\u0938\u093e\u0920\u0940 \u090f\u0915 \u0938\u0902\u0938\u093e\u0927\u0928 \u0906\u0939\u0947, \u091c\u094d\u092f\u093e\u092e\u0941\u0933\u0947 \u0928\u0935\u0940\u0928 \u0938\u0902\u0936\u094b\u0927\u0928 \u092a\u094d\u0930\u0915\u0932\u094d\u092a\u093e\u0902\u091a\u094d\u092f\u093e \u092a\u094d\u0930\u0917\u0924\u0940\u0932\u093e \u091a\u093e\u0932\u0928\u093e \u092e\u093f\u0933\u0947\u0932.<\/li>\n<\/ul>\n<h4><strong>\u0938\u0902\u0938\u094d\u0925\u093e\u0924\u094d\u092e\u0915 \u092a\u0941\u0928\u0930\u093e\u0935\u0932\u094b\u0915\u0928 \u092e\u0902\u0921\u0933\u093e\u091a\u094d\u092f\u093e \u092e\u0902\u091c\u0941\u0930\u0940:<\/strong><\/h4>\n<p>PRF \u0935\u0948\u0926\u094d\u092f\u0915\u0940\u092f \u0906\u0923\u093f \u0938\u0902\u0936\u094b\u0927\u0928 \u0921\u0947\u091f\u093e\u092c\u0947\u0938 \u0939\u093e \u0938\u0902\u0938\u094d\u0925\u093e\u0924\u094d\u092e\u0915 \u092a\u0941\u0928\u0930\u093e\u0935\u0932\u094b\u0915\u0928 \u092e\u0902\u0921\u0933 (IRB) \u0906\u0939\u0947 \u091c\u094b \u0931\u094d\u0939\u094b\u0921 \u0906\u092f\u0932\u0902\u0921 \u0939\u0949\u0938\u094d\u092a\u093f\u091f\u0932 \u0906\u0923\u093f \u092c\u094d\u0930\u093e\u0909\u0928 \u092f\u0941\u0928\u093f\u0935\u094d\u0939\u0930\u094d\u0938\u093f\u091f\u0940 \u0938\u092e\u093f\u0924\u094d\u092f\u093e\u0902\u0928\u0940 \u092e\u093e\u0928\u0935\u0940 \u0935\u093f\u0937\u092f\u093e\u0902\u091a\u094d\u092f\u093e \u0938\u0902\u0930\u0915\u094d\u0937\u0923\u093e\u0935\u0930 \u092e\u0902\u091c\u0942\u0930 \u0915\u0947\u0932\u093e \u0906\u0939\u0947. \u0930\u094b\u0921 \u0906\u092f\u0932\u0902\u0921 \u0939\u0949\u0938\u094d\u092a\u093f\u091f\u0932 \u092b\u0947\u0921\u0930\u0932 \u0935\u093e\u0907\u0921 \u0972\u0936\u094d\u092f\u0941\u0930\u0928\u094d\u0938 FWA00001230, \u0938\u094d\u091f\u0921\u0940 CMTT# 0152-01, \u092c\u094d\u0930\u093e\u0909\u0928 \u092f\u0941\u0928\u093f\u0935\u094d\u0939\u0930\u094d\u0938\u093f\u091f\u0940 \u092b\u0947\u0921\u0930\u0932 \u0935\u093e\u0907\u0921 \u0972\u0936\u094d\u092f\u0941\u0930\u0928\u094d\u0938 FWA 00004460, \u0938\u094d\u091f\u0921\u0940 CMTT# 0211991243<\/p>\n<h4 style=\"font-weight: 400;\"><strong>\u092a\u094d\u0930\u0915\u093e\u0936\u0928\u093e\u0902\u092e\u0927\u094d\u092f\u0947 \u0938\u093e\u0939\u093f\u0924\u094d\u092f\u093e\u091a\u093e \u0935\u093e\u092a\u0930:<\/strong><\/h4>\n<p style=\"font-weight: 400;\">\u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0930\u093f\u0938\u0930\u094d\u091a \u092b\u093e\u090a\u0902\u0921\u0947\u0936\u0928 \u092e\u0947\u0921\u093f\u0915\u0932 \u0905\u0901\u0921 \u0930\u093f\u0938\u0930\u094d\u091a \u0921\u0947\u091f\u093e\u092c\u0947\u0938\u092e\u0927\u0942\u0928 \u092e\u093f\u0933\u093e\u0932\u0947\u0932\u094d\u092f\u093e \u092e\u093e\u0939\u093f\u0924\u0940\u091a\u094d\u092f\u093e \u0935\u093e\u092a\u0930\u093e\u092e\u0941\u0933\u0947 \u0928\u093f\u0930\u094d\u092e\u093e\u0923 \u091d\u093e\u0932\u0947\u0932\u094d\u092f\u093e \u0938\u0930\u094d\u0935 \u092a\u094d\u0930\u0915\u093e\u0936\u0928\u093e\u0902\u0938\u093e\u0920\u0940, \u0938\u0902\u0936\u094b\u0927\u0915\u093e\u0902\u0928\u0940 \u0916\u093e\u0932\u0940\u0932 \u0905\u0935\u0924\u0930\u0923 \u0938\u093e\u092e\u0917\u094d\u0930\u0940 \u0906\u0923\u093f \u092a\u0926\u094d\u0927\u0924\u0940 \u0935\u093f\u092d\u093e\u0917\u093e\u0924 \u0938\u092e\u093e\u0935\u093f\u0937\u094d\u091f \u0915\u0930\u0923\u0947 \u0906\u0935\u0936\u094d\u092f\u0915 \u0906\u0939\u0947 (\u092b\u0915\u094d\u0924 \u092a\u094b\u091a\u092a\u093e\u0935\u0924\u0940 \u0928\u093e\u0939\u0940). \u0938\u0902\u0936\u094b\u0927\u0928\u093e\u0938\u093e\u0920\u0940 \u0915\u094b\u0923\u0924\u094d\u092f\u093e \u092e\u093e\u0939\u093f\u0924\u0940\u091a\u093e \u092a\u0941\u0930\u0935\u0920\u093e \u0915\u0947\u0932\u093e \u0917\u0947\u0932\u093e \u092f\u093e\u0935\u0930 \u0905\u0935\u0932\u0902\u092c\u0942\u0928, \u0939\u0947 \u0936\u092c\u094d\u0926\u093e\u0902\u0915\u0928 \u0925\u094b\u0921\u0947\u0938\u0947 \u092c\u0926\u0932\u0942 \u0936\u0915\u0924\u0947.<\/p>\n<p style=\"font-weight: 400;\">\u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0930\u093f\u0938\u0930\u094d\u091a \u092b\u093e\u0909\u0902\u0921\u0947\u0936\u0928 (\u092a\u0940\u0906\u0930\u090f\u092b) \u092e\u0947\u0921\u093f\u0915\u0932 \u0905\u0901\u0921 \u0930\u093f\u0938\u0930\u094d\u091a \u0921\u0947\u091f\u093e\u092c\u0947\u0938 (\u092a\u0940\u0906\u0930\u090f\u092b) \u0915\u0921\u0942\u0928 \u0913\u0933\u0916\u0932\u0940 \u091c\u093e\u0923\u093e\u0930\u0940 \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u092e\u093e\u0939\u093f\u0924\u0940 \u092a\u094d\u0930\u093e\u092a\u094d\u0924 \u091d\u093e\u0932\u0940 \u0906\u0939\u0947.<a href=\"https:\/\/www.progeriaresearch.org\/mr\/\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/www.progeriaresearch.org&amp;source=gmail&amp;ust=1656539975208000&amp;usg=AOvVaw2-Ugfzc0IoTq-jMG-qMW0F\">www.progeriaresearch.org<\/a>).\u201d<\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner use_custom_gutter=\u201don\u201d gutter_width=\u201d1\u2033 _builder_version=\u201d4.16\u2033 background_color=\u201d#29327a\u201d custom_padding=\u201d40px|35px|35.2344px|35px|false|true\u201d animation_style=\u201dslide\u201d animation_direction=\u201dright\u201d animation_intensity_slide=\u201d25%\u201dborder_width_bottom=\u201d10px\u201d\u0915\u093f\u0902\u0935\u093e \u092c\u0949\u0930\u094d\u0921\u0930 10TP_2\u201d\u0915\u093f\u0902\u0935\u093e \u091f\u0940\u090f\u092b\u0921\u0940 5 \u092c\u0949\u0930\u094d\u0921\u0930 locked=\u201doff\u201d global_colors_info=\u201d{}\u201d][et_pb_column_inner saved_specialty_column_type=\u201d3_4\u2033 _builder_version=\u201d4.16\u2033 custom_padding=\u201d|||\u201d global_colors_info=\u201d{}\u201d custom_padding__hover=\u201d|||\u201d][et_pb_text admin_label=\u201d\u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0930\u093f\u0938\u0930\u094d\u091a \u092b\u093e\u090a\u0902\u0921\u0947\u0936\u0928 \u092e\u0947\u0921\u093f\u0915\u0932 \u0905\u0901\u0921 \u0930\u093f\u0938\u0930\u094d\u091a \u0921\u0947\u091f\u093e\u092c\u0947\u0938 \u092e\u0927\u0942\u0928 \u092a\u094d\u0930\u0915\u093e\u0936\u093f\u0924 \u0939\u094b\u0923\u093e\u0930\u0940 \u092a\u094d\u0930\u0915\u093e\u0936\u0928\u0947\u201d _builder_version=\u201d4.16\u2033 header_text_align=\u201dcenter\u201d header_text_color=\u201d5koutdarkout=\u201d1center &quot; animation_style=\u201dfade\u201d header_font_size_tablet=\u201d\u201d header_font_size_phone=\u201d30px\u201d header_font_size_last_edited=\u201don|desktop\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n<h2 style=\"text-align: center;\"><strong>\u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0930\u093f\u0938\u0930\u094d\u091a \u092b\u093e\u090a\u0902\u0921\u0947\u0936\u0928 \u092e\u0947\u0921\u093f\u0915\u0932 \u0905\u0901\u0921 \u0930\u093f\u0938\u0930\u094d\u091a \u0921\u0947\u091f\u093e\u092c\u0947\u0938\u092e\u0927\u0942\u0928 \u092a\u094d\u0930\u0915\u093e\u0936\u093f\u0924 \u0939\u094b\u0923\u093e\u0930\u0940 \u092a\u094d\u0930\u0915\u093e\u0936\u0928\u0947<\/strong><\/h2>\n<p>\u00a0<\/p>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner column_structure=\u201d1_2,1_2\u2033 custom_padding_last_edited=\u201don|phone\u201d padding_left_right_link_1=\u201dfalse\u201d_left_right_link_1=\u201dfalse\u201d_left_fal\u201d padding=right_2 _builder_version=\u201d4.16\u2033 custom_padding=\u201d|35px|0|0px|false|false\u201d custom_padding_tablet=\u201d|35px||35px||true\u201d custom_padding_phone=\u201d\u201d animation_direction=\u201dtop\u201d border_width_bottom=\u201d1 border_color_bottom=\u201d#8fd2ed\u201d global_colors_info=\u201d{}\u201d][et_pb_column_inner type=\u201d1_2\u2033 saved_specialty_column_type=\u201d3_4\u2033 _builder_version=\u201d4.16\u2033 custom_padding=\u201d|20p global_colors_info=\u201d{}\u201d custom_padding__hover=\u201d|||\u201d][et_pb_text _builder_version=\u201d4.16\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n<p>\u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0930\u093f\u0938\u0930\u094d\u091a \u092b\u093e\u0909\u0902\u0921\u0947\u0936\u0928 \u092e\u0947\u0921\u093f\u0915\u0932 \u0905\u0901\u0921 \u0930\u093f\u0938\u0930\u094d\u091a \u0921\u0947\u091f\u093e\u092c\u0947\u0938\u0928\u0947 \u0916\u093e\u0932\u0940\u0932 \u0935\u0948\u0926\u094d\u092f\u0915\u0940\u092f \u092a\u094d\u0930\u0915\u093e\u0936\u0928\u093e\u0902\u092e\u0927\u094d\u092f\u0947 \u092f\u094b\u0917\u0926\u093e\u0928 \u0926\u093f\u0932\u0947 \u0906\u0939\u0947:<\/p>\n<p><strong>\u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u0915\u0947\u0905\u0930 \u0939\u0901\u0921\u092c\u0941\u0915<\/strong><\/p>\n<p><em>\u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0939\u0901\u0921\u092c\u0941\u0915; \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0905\u0938\u0932\u0947\u0932\u094d\u092f\u093e \u092e\u0941\u0932\u093e\u0902\u091a\u094d\u092f\u093e \u0915\u0941\u091f\u0941\u0902\u092c\u093e\u0902\u0938\u093e\u0920\u0940 \u0906\u0923\u093f \u0906\u0930\u094b\u0917\u094d\u092f \u0938\u0947\u0935\u093e \u092a\u094d\u0930\u0926\u093e\u0924\u094d\u092f\u093e\u0902\u0938\u093e\u0920\u0940 \u092e\u093e\u0930\u094d\u0917\u0926\u0930\u094d\u0936\u0915.<\/em> \u0917\u0949\u0930\u094d\u0921\u0928, \u0932\u0947\u0938\u094d\u0932\u0940 \u092c\u0940., \u0915\u093e\u0930\u094d\u092f\u0915\u093e\u0930\u0940 \u0938\u0902\u092a\u093e\u0926\u0915. \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0930\u093f\u0938\u0930\u094d\u091a \u092b\u093e\u0909\u0902\u0921\u0947\u0936\u0928 \u0926\u094d\u0935\u093e\u0930\u0947 \u0915\u0949\u092a\u0940\u0930\u093e\u0907\u091f 2019. \u0938\u0930\u094d\u0935 \u0939\u0915\u094d\u0915 \u0930\u093e\u0916\u0940\u0935.<\/p>\n<p>\u00a0\u0939\u0901\u0921\u092c\u0941\u0915\u091a\u0940 \u092a\u0939\u093f\u0932\u0940 \u0906\u0935\u0943\u0924\u094d\u0924\u0940 \u0938\u094d\u092a\u0945\u0928\u093f\u0936 \u0906\u0923\u093f \u092a\u094b\u0930\u094d\u0924\u0941\u0917\u0940\u091c \u0906\u0935\u0943\u0924\u094d\u0924\u094d\u092f\u093e\u0902\u092e\u0927\u094d\u092f\u0947 \u0909\u092a\u0932\u092c\u094d\u0927 \u0906\u0939\u0947. \u0939\u0901\u0921\u092c\u0941\u0915\u091a\u094d\u092f\u093e \u0926\u0941\u0938\u0931\u094d\u092f\u093e \u0906\u0935\u0943\u0924\u094d\u0924\u0940\u091a\u0947 \u0938\u094d\u092a\u0945\u0928\u093f\u0936 \u0906\u0923\u093f \u092a\u094b\u0930\u094d\u0924\u0941\u0917\u0940\u091c\u092e\u0927\u0940\u0932 \u092d\u093e\u0937\u093e\u0902\u0924\u0930 \u0909\u092a\u0932\u092c\u094d\u0927 \u091d\u093e\u0932\u094d\u092f\u093e\u0935\u0930 \u092a\u094b\u0938\u094d\u091f \u0915\u0947\u0932\u0947 \u091c\u093e\u0924\u0940\u0932.<\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][\/et_pb_column_inner][et_pb_column_inner type=\u201d1_2\u2033 saved_specialty_column_type=\u201d3_4\u2033 _builder_version=\u201d4.16\u2033 custom_padding=\u201d|||15px\u201d global_colors_info=\u201d} custom_padding__hover=\u201d|||\u201d][et_pb_button button_url=\u201dhttps:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/01\/Handbook-2018-PDF-One-File-v3-1.pdf\u201d url_new_window =\u201d\u091a\u093e\u0932\u0942\u201d \u092c\u091f\u0928_\u091f\u0947\u0915\u094d\u0938\u094d\u091f=\u201d\u0926\u0941\u0938\u0930\u0940 \u0906\u0935\u0943\u0924\u094d\u0924\u0940 \u2013 \u0907\u0902\u0917\u094d\u0930\u091c\u0940\u201d button_alignment=\u201dcenter\u201d admin_label=\u201d2\u0930\u093e \u0938\u0902\u0938\u094d\u0915\u0930\u0923 \u2013 \u0907\u0902\u0917\u094d\u0930\u091c\u0940\u201d _builder_version=\u201d4.16\u2033 background_layout=\u201ddark\u201d custom_margin=\u201d||20px\u201d animation_style=\u201dslide\u201d animation_direction=\u201dright\u201d animation_intensity_slide=\u201dT_TP0=\u201d2513 \u091f\u0945\u092c\u0932\u0947\u091f=\u201d2513\u201d \u091f\u0945\u092c\u0932\u0947\u091f custom_css_main_element=&quot;\u0930\u0941\u0902\u0926\u0940: 70%;&quot; \u0917\u094d\u0932\u094b\u092c\u0932_\u0930\u0902\u0917_\u092e\u093e\u0939\u093f\u0924\u0940=\u201d{}\u201d]<br \/>\n[\/et_pb_button][et_pb_button button_url=&#8221;https:\/\/www.progeriaresearch.org\/assets\/files\/pdf\/PRF%20Handbook%20Spanish.pdf&#8221; url_new_window=&#8221;on&#8221; button_text=&#8221;1st Edition &#8211; Spanish&#8221; button_alignment=&#8221;center&#8221; admin_label=&#8221;1st Edition &#8211; Spanish&#8221; _builder_version=&#8221;4.16&#8243; background_layout=&#8221;dark&#8221; custom_margin=&#8221;||20px&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;right&#8221; animation_intensity_slide=&#8221;25%&#8221; z_index_tablet=&#8221;500&#8243; custom_css_main_element=&#8221;width: 70%;&#8221; global_colors_info=&#8221;{}&#8221;]<br \/>\n[\/et_pb_button][et_pb_button button_url=\u201dhttps:\/\/www.progeriaresearch.org\/assets\/files\/pdf\/Handbook\u2014Portuguese.pdf\u201d button_text=\u201d\u092a\u0939\u093f\u0932\u0940 \u0906\u0935\u0943\u0924\u094d\u0924\u0940 \u2013 \u092a\u094b\u0930\u094d\u0924\u0941\u0917\u0940\u091c\u201d button_alignment=\u201dcenter\u201d admin_label=\u201d1\u0932\u0940 \u0906\u0935\u0943\u0924\u094d\u0924\u0940 \u2013 \u092a\u094b\u0930\u094d\u0924\u0941\u0917\u0940\u091c&quot; _builder_version=\u201d4.16\u2033 background_layout=\u201ddark\u201d custom_margin=\u201d||20px\u201d animation_style=\u201dslide\u201d animation_direction=\u201dright\u201d animation_intensity_slide=\u201d25%\u201d z_index_tablet=\u201d500\u2033 custom_css_main_tp=1with3telement; \u0917\u094d\u0932\u094b\u092c\u0932_\u0930\u0902\u0917_\u092e\u093e\u0939\u093f\u0924\u0940=\u201d{}\u201d]<br \/>\n[\/et_pb_button][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner custom_padding_last_edited=\u201don|phone\u201d _builder_version=\u201d4.16\u2033 custom_padding=\u201d0|35px|0|0pxal\u201dal custom_padding_tablet=\u201d|35px||35px||true\u201d custom_padding_phone=\u201d\u201d animation_direction=\u201dtop\u201d global_colors_info=\u201d{}\u201d][et_pb_column_inner saved_specialty_column_type=\u201d3_4\u2033 _builder\u2033_padding==\u201d||4\u2033 _builder\u2033_padding==\u201d| global_colors_info=\u201d{}\u201d custom_padding__hover=\u201d|||\u201d][et_pb_text admin_label=\u201dJournal Articles\u201d _builder_version=\u201d4.17.6\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201dindex_0\u201d=\u201d_5 \u091f\u0945\u092c\u0932\u0947\u091f\u201d_00=\u201d\u092a\u0941\u0928\u0930\u093e\u0935\u0943\u0924\u094d\u0924\u0940\u201d \u0917\u094d\u0932\u094b\u092c\u0932_\u0930\u0902\u0917_\u092e\u093e\u0939\u093f\u0924\u0940=\u201d{}\u201d]<\/p>\n<h4><strong>\u091c\u0930\u094d\u0928\u0932 \u0932\u0947\u0916<\/strong><\/h4>\n<p class=\"m_5556619090296294739MsoNoSpacing\"><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35752705\/\" target=\"_blank\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/pubmed.ncbi.nlm.nih.gov\/35752705\/&amp;source=gmail&amp;ust=1658414740427000&amp;usg=AOvVaw3JN2-5dxsoBxFs9Lk6gXDY\" rel=\"noopener\">\u0939\u091a\u093f\u0928\u094d\u0938\u0928-\u0917\u093f\u0932\u092b\u094b\u0930\u094d\u0921 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0938\u093f\u0902\u0921\u094d\u0930\u094b\u092e\u092e\u0927\u094d\u092f\u0947 \u0915\u094d\u0932\u094b\u0928\u0932 \u0939\u0947\u092e\u0945\u091f\u094b\u092a\u094b\u0908\u0938\u093f\u0938 \u092a\u094d\u0930\u091a\u0932\u093f\u0924 \u0928\u093e\u0939\u0940<\/a><\/strong><br \/><span><u><\/u><u><\/u><\/span><span>D\u00edez-D\u00edez M, Amor\u00f3s-P\u00e9rez M, de la Barrera J, et al. [\u091b\u092a\u093e\u0908\u092a\u0942\u0930\u094d\u0935\u0940 \u0911\u0928\u0932\u093e\u0907\u0928 \u092a\u094d\u0930\u0915\u093e\u0936\u093f\u0924, 2022 \u091c\u0942\u0928 25]. \u091c\u0947\u0930\u094b\u0938\u093e\u092f\u0928\u094d\u0938. 2022;10.1007\/s11357-022-00607-<wbr \/>2. doi:10.1007\/s11357-022-00607-2<\/span><\/p>\n<p><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29710166\/?from_term=Gordon+LB+Association+of+&amp;from_pos=1\" target=\"_blank\" rel=\"noopener noreferrer\">\u0905\u0938\u094b\u0938\u093f\u090f\u0936\u0928 \u0911\u092b \u0932\u094b\u0928\u093e\u092b\u0930\u094d\u0928\u093f\u092c \u091f\u094d\u0930\u0940\u091f\u092e\u0947\u0902\u091f \u0935\u093f\u0930\u0941\u0926\u094d\u0927 \u0939\u091a\u093f\u0928\u094d\u0938\u0928-\u0917\u093f\u0932\u092b\u094b\u0930\u094d\u0921 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0938\u093f\u0902\u0921\u094d\u0930\u094b\u092e \u0905\u0938\u0932\u0947\u0932\u094d\u092f\u093e \u0930\u0941\u0917\u094d\u0923\u093e\u0902\u092e\u0927\u094d\u092f\u0947 \u092e\u0943\u0924\u094d\u092f\u0942 \u0926\u0930\u093e\u0938\u0939 \u0909\u092a\u091a\u093e\u0930 \u0928\u093e\u0939\u0940.<\/a><\/strong><br \/>Gordon LB, Shappell H, Massaro J, D&#039;Agostino RB Sr, Brazier J, Campbell SE, Kleinman ME, Kieran MW. Gordon LB, et al. \u091c\u093e\u092e\u093e. 2018 \u090f\u092a\u094d\u0930\u093f\u0932 24;319(16):1687-1695. doi: 10.1001\/jama.2018.3264.<\/p>\n<p><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30450527\/?from_term=lessel+d&amp;from_page=4&amp;from_pos=4\" target=\"_blank\" rel=\"noopener noreferrer\">\u090f\u0932\u090f\u092e\u090f\u0928\u090f-\u0928\u0915\u093e\u0930\u093e\u0924\u094d\u092e\u0915 \u0915\u093f\u0936\u094b\u0930 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u0949\u0907\u0921 \u092a\u094d\u0930\u0915\u0930\u0923\u093e\u0902\u091a\u0947 \u0935\u093f\u0936\u094d\u0932\u0947\u0937\u0923 Wiedemann-Rautenstrauch-\u0938\u093e\u0930\u0916\u094d\u092f\u093e \u0938\u093f\u0902\u0921\u094d\u0930\u094b\u092e\u092e\u0927\u094d\u092f\u0947 \u092c\u093e\u092f\u0932\u0947\u0932\u093f\u0915 POLR3A \u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928\u093e\u0902\u091a\u0940 \u092a\u0941\u0937\u094d\u091f\u0940 \u0915\u0930\u0924\u0947 \u0906\u0923\u093f PYCR1 \u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928\u093e\u0902\u091a\u094d\u092f\u093e \u092b\u0947\u0928\u094b\u091f\u093e\u0907\u092a\u093f\u0915 \u0938\u094d\u092a\u0947\u0915\u094d\u091f\u094d\u0930\u092e\u091a\u093e \u0935\u093f\u0938\u094d\u0924\u093e\u0930 \u0915\u0930\u0924\u0947.<\/a><\/strong><br \/>Lessel D, Ozel AB, Campbell SE, Saadi A, Arlt MF, McSweeney KM, Plaiasu V, Szakszon K, Sz\u0151ll\u0151s A, Rusu C, Rojas AJ, Lopez-Valdez J, Thiele H, N\u00fcrnberg P, Nickerson DA, Bamshad MJ, Li JZ, Kubisch C, Glover TW, Gordon LB.Lessel D, et al. \u0906\u092e\u094d\u0939\u0940 \u091c\u0947\u0928\u0947\u091f. 2018 \u0921\u093f\u0938\u0947\u0902\u092c\u0930;137(11-12):921-939. doi: 10.1007\/s00439-018-1957-1. Epub 2018 \u0928\u094b\u0935\u094d\u0939\u0947\u0902 19.Hum Genet. 2018. PMID: 30450527<\/p>\n<p><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29581305\/?from_term=dubose+a&amp;from_pos=1\" target=\"_blank\" rel=\"noopener noreferrer\">\u090f\u0935\u094d\u0939\u0930\u094b\u0932\u093f\u092e\u0938 \u0932\u0945\u092e\u093f\u0928\u094b\u092a\u0945\u0925\u0940-\u0930\u0941\u0917\u094d\u0923 \u092b\u093e\u092f\u092c\u094d\u0930\u094b\u092c\u094d\u0932\u093e\u0938\u094d\u091f\u094d\u0938\u092e\u0927\u0940\u0932 \u090f\u0915\u093e\u0927\u093f\u0915 \u0938\u0947\u0932\u094d\u092f\u0941\u0932\u0930 \u0926\u094b\u0937\u093e\u0902\u092a\u093e\u0938\u0942\u0928 \u092c\u091a\u093e\u0935 \u0915\u0930\u0924\u0947. <\/a><\/strong><br \/>DuBose AJ, Lichtenstein ST, Petrash NM, Erdos MR, Gordon LB, Collins FS.DuBose AJ, et al. Proc Natl Acad Sci US A. 2018 \u090f\u092a\u094d\u0930\u093f\u0932 17;115(16):4206-4211. doi: 10.1073\/pnas.1802811115. Epub 2018 \u092e\u093e\u0930\u094d\u091a 26. Proc Natl Acad Sci US A. 2018. PMID: 29581305<\/p>\n<p><strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28756152\" target=\"_blank\" rel=\"noopener noreferrer\">\u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e\u091a\u0940 \u0928\u0947\u0924\u094d\u0930\u0930\u094b\u0917\u0935\u093f\u0937\u092f\u0915 \u0935\u0948\u0936\u093f\u0937\u094d\u091f\u094d\u092f\u0947.<br \/><\/a><\/strong>Mantagos IS, Kleinman ME, Kieran MW, Gordon LB.<br \/>Am J Ophthalmol. 2017 \u091c\u0941\u0932\u0948 27. pii: S0002-9394(17)30317-3. doi: 10.1016\/j.ajo.2017.07.020. [\u092e\u0941\u0926\u094d\u0930\u0923\u093e\u091a\u094d\u092f\u093e \u092a\u0941\u0922\u0947 Epub]<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27920058\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>\u0939\u091a\u093f\u0928\u094d\u0938\u0928-\u0917\u093f\u0932\u092b\u094b\u0930\u094d\u0921 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0938\u093f\u0902\u0921\u094d\u0930\u094b\u092e \u0905\u0938\u0932\u0947\u0932\u094d\u092f\u093e \u092e\u0941\u0932\u093e\u092e\u0927\u094d\u092f\u0947 \u0928\u0935\u0940\u0928 \u0938\u094b\u092e\u093e\u091f\u093f\u0915 \u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928\u093e\u092e\u0941\u0933\u0947 \u0906\u0902\u0936\u093f\u0915 \u092c\u091a\u093e\u0935 \u0939\u094b\u0924\u094b.<\/strong><br \/><\/a>Bar DZ, Arlt MF, Brazier JF, Norris WE, Campbell SE, Chines P, Larrieu D, Jackson SP, Collins FS, Glover TW, Gordon LB.<br \/>\u091c\u0947 \u092e\u0947\u0921 \u091c\u0947\u0928\u0947\u091f. 2017 \u092e\u093e\u0930\u094d\u091a;54(3):212-216. doi: 10.1136\/jmedgenet-2016-104295. Epub 2016 \u0921\u093f\u0938\u0947\u0902\u092c\u0930 5.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27799555\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>\u092a\u094d\u0930\u094b\u091c\u0947\u0930\u0949\u0907\u0921 \u092e\u093e\u0908\u0938 \u0906\u0923\u093f \u0939\u091a\u093f\u0928\u094d\u0938\u0928-\u0917\u093f\u0932\u092b\u094b\u0930\u094d\u0921 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0938\u093f\u0902\u0921\u094d\u0930\u094b\u092e \u0930\u0942\u0917\u094d\u0923\u093e\u0902\u092e\u0927\u094d\u092f\u0947 \u0939\u094d\u0930\u0926\u092f\u093e\u091a\u093e \u0935\u093f\u0926\u094d\u092f\u0941\u0924 \u0926\u094b\u0937 \u0928\u094d\u092f\u0942\u0915\u094d\u0932\u093f\u092f\u0930 \u0932\u0945\u092e\u093f\u0928\u093e \u092c\u0926\u0932.<\/strong><br \/><\/a>\u0930\u093f\u0935\u0947\u0930\u093e-\u091f\u094b\u0930\u0947\u0938 \u091c\u0947, \u0915\u0945\u0932\u094d\u0935\u094b \u0938\u0940\u091c\u0947, \u0932\u0945\u091a \u090f, \u0917\u0941\u091d\u092e\u093e\u0928-\u092e\u093e\u0930\u094d\u091f\u093f\u0928\u0947\u091d \u091c\u0940, \u0915\u0945\u092c\u0932\u0947\u0930\u094b \u0906\u0930, \u0917\u094b\u0928\u094d\u091d\u093e\u0932\u0947\u091d-\u0917\u094b\u092e\u0947\u091d \u0938\u0940, \u091c\u093f\u092e\u0947\u0928\u0947\u091d-\u092c\u094b\u0930\u0947\u0917\u094d\u092f\u0941\u0930\u094b \u090f\u0932\u091c\u0947, \u0917\u0941\u0906\u0921\u093f\u0915\u094d\u0938 \u091c\u0947\u090f, \u0913\u0938\u094b\u0930\u093f\u0913 \u090f\u092b\u091c\u0940, \u0932\u094b\u092a\u0947\u091d-\u0913\u091f\u093f\u0928 \u0938\u0940, \u0939\u0947\u0930\u0930\u093e\u0908\u091c-\u092e\u093e\u0930\u094d\u091f\u093f\u0928\u0947\u091d \u090f, \u0915\u0945\u092c\u0932\u0947\u0930\u094b, \u0915\u0945\u092c\u0945\u0932\u0947\u091d , \u092c\u0947\u0928\u093f\u091f\u0947\u091d \u0906\u0930, \u0917\u0949\u0930\u094d\u0921\u0928 LB, Jalife J, P\u00e9rez-Pomares JM, Tamargo J, Delp\u00f3n E, Hove-Madsen L, Filgueiras-Rama D, Andr\u00e9s V.<br \/>Proc Natl Acad Sci US A. 2016 \u0928\u094b\u0935\u094d\u0939\u0947\u0902\u092c\u0930 15;113(46):E7250-E7259. Epub 2016 \u0911\u0915\u094d\u091f\u094b\u092c\u0930 31.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27400896\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>\u0939\u091a\u093f\u0928\u094d\u0938\u0928-\u0917\u093f\u0932\u092b\u094b\u0930\u094d\u0921 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0938\u093f\u0902\u0921\u094d\u0930\u094b\u092e \u0905\u0938\u0932\u0947\u0932\u094d\u092f\u093e \u092e\u0941\u0932\u093e\u0902\u092e\u0927\u094d\u092f\u0947 \u092a\u094d\u0930\u0925\u093f\u0928\u0947 \u092b\u0930\u094d\u0928\u0947\u0938\u093f\u0932\u0947\u0936\u0928 \u0907\u0928\u0939\u093f\u092c\u093f\u091f\u0930 \u0932\u094b\u0928\u093e\u092b\u0930\u094d\u0928\u093f\u092c, \u092a\u094d\u0930\u0935\u093e\u0938\u094d\u091f\u093e\u091f\u093f\u0928 \u0906\u0923\u093f \u091d\u094b\u0932\u0947\u0921\u094d\u0930\u0949\u0928\u093f\u0915 \u090d\u0938\u093f\u0921\u091a\u0940 \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u091a\u093e\u091a\u0923\u0940.<\/strong><br \/><\/a>\u0917\u0949\u0930\u094d\u0921\u0928 LB, Kleinman ME, Massaro J, D&#039;Agostino RB Sr, Shappell H, Gerhard-Herman M, Smoot LB, Gordon CM, Cleveland RH, Nazarian A, Snyder BD, Ulrich NJ, Silvera VM, Liang MG, Quinn N, \u092e\u093f\u0932\u0930 \u0921\u0940\u091f\u0940, \u0939\u0941\u0939 \u090f\u0938\u0935\u093e\u092f, \u0921\u093e\u0909\u091f\u0928 \u090f\u090f, \u0932\u093f\u091f\u0932\u092b\u093f\u0932\u094d\u0921 \u0915\u0947, Greer MM, Kieran MW.<br \/>\u0905\u092d\u093f\u0938\u0930\u0923. 2016 \u091c\u0941\u0932\u0948 12;134(2):114-25. doi: 10.1161\/CIRCULATIONAHA.116.022188.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26564085\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>\u0939\u091a\u093f\u0928\u094d\u0938\u0928-\u0917\u093f\u0932\u092b\u094b\u0930\u094d\u0921 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0938\u093f\u0902\u0921\u094d\u0930\u094b\u092e.<\/strong><br \/><\/a>\u0909\u0932\u094d\u0930\u093f\u091a \u090f\u0928\u091c\u0947, \u0917\u0949\u0930\u094d\u0921\u0928 \u090f\u0932\u092c\u0940.<br \/>\u0939\u0901\u0921\u092c\u0940 \u0915\u094d\u0932\u093f\u0928 \u0928\u094d\u092f\u0942\u0930\u094b\u0932. 2015;132:249-64.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24795390\"><strong>\u0939\u091a\u093f\u0928\u094d\u0938\u0928-\u0917\u093f\u0932\u092b\u094b\u0930\u094d\u0921 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0938\u093f\u0902\u0921\u094d\u0930\u094b\u092e\u092e\u0927\u094d\u092f\u0947 \u091c\u0917\u0923\u094d\u092f\u093e\u0935\u0930 \u092b\u093e\u0930\u094d\u0928\u0947\u0938\u093f\u0932\u0947\u0936\u0928 \u0907\u0928\u0939\u093f\u092c\u093f\u091f\u0930\u091a\u093e \u092a\u094d\u0930\u092d\u093e\u0935.<\/strong><br \/><\/a>\u0917\u0949\u0930\u094d\u0921\u0928 \u090f\u0932\u092c\u0940, \u092e\u093e\u0938\u093e\u0930\u094b \u091c\u0947, \u0921\u0940&#039;\u0905\u0917\u094b\u0938\u094d\u091f\u093f\u0928\u094b \u0906\u0930\u092c\u0940 \u0938\u0940\u0928\u093f\u092f\u0930, \u0915\u0945\u092e\u094d\u092a\u092c\u0947\u0932 \u090f\u0938\u0908, \u092c\u094d\u0930\u093e\u091d\u093f\u092f\u0930 \u091c\u0947, \u092c\u094d\u0930\u093e\u0909\u0928 \u0921\u092c\u094d\u0932\u094d\u092f\u0942\u091f\u0940, \u0915\u094d\u0932\u0947\u0928\u092e\u0928 \u090f\u092e\u0908, \u0915\u093f\u0930\u0928 \u090f\u092e\u0921\u092c\u094d\u0932\u094d\u092f\u0942; \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u091f\u094d\u0930\u093e\u092f\u0932\u094d\u0938 \u0938\u0939\u092f\u094b\u0917\u0940.<br \/>\u0905\u092d\u093f\u0938\u0930\u0923. 2014 \u091c\u0941\u0932\u0948 1;130(1):27-34. doi: 10.1161\/CIRCULATIONAHA.113.008285. Epub 2014 \u092e\u0947 2.<\/p>\n<p><strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24456199\">\u0939\u091a\u093f\u0928\u094d\u0938\u0928-\u0917\u093f\u0932\u092b\u094b\u0930\u094d\u0921 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0938\u093f\u0902\u0921\u094d\u0930\u094b\u092e\u091a\u0947 \u092a\u094d\u0930\u093e\u0930\u0902\u092d\u093f\u0915 \u0924\u094d\u0935\u091a\u093e \u092a\u094d\u0930\u0915\u091f\u0940\u0915\u0930\u0923.<\/a>\u00a0<\/strong>\u0930\u094b\u0930\u094d\u0915 \u091c\u0947\u090f\u092b, \u0939\u0941\u0906\u0902\u0917 \u091c\u0947\u091f\u0940, \u0917\u0949\u0930\u094d\u0921\u0928 \u090f\u0932\u092c\u0940, \u0915\u094d\u0932\u0947\u0928\u092e\u0928 \u090f\u092e, \u0915\u093f\u0930\u0928 \u090f\u092e\u0921\u092c\u094d\u0932\u094d\u092f\u0942, \u0932\u093f\u0906\u0902\u0917 \u090f\u092e\u091c\u0940. \u092a\u0947\u0921\u093f\u092f\u093e\u091f\u0930 \u0921\u0930\u094d\u092e\u093e\u091f\u094b\u0932. 2014 \u091c\u093e\u0928\u0947\u0935\u093e\u0930\u0940 24: 1-7. doi: 10.1111\/pde.12284.<\/p>\n<p class=\"desc\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23897869\"><b>\u0928\u094d\u092f\u0942\u0930\u094b\u0932\u0949\u091c\u093f\u0915\u0932<\/b>\u00a0<b>\u0935\u0948\u0936\u093f\u0937\u094d\u091f\u094d\u092f\u0947<\/b>\u00a0\u091a\u094d\u092f\u093e\u00a0<b>\u0939\u091a\u093f\u0928\u094d\u0938\u0928-\u0917\u093f\u0932\u092b\u094b\u0930\u094d\u0921<\/b>\u00a0\u0932\u094b\u0928\u093e\u092b\u0930\u094d\u0928\u093f\u092c \u0909\u092a\u091a\u093e\u0930\u093e\u0928\u0902\u0924\u0930 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0938\u093f\u0902\u0921\u094d\u0930\u094b\u092e.<br \/><\/a>\u0909\u0932\u0930\u093f\u091a \u090f\u0928\u091c\u0947, \u0915\u093f\u0930\u0928 \u090f\u092e\u0921\u092c\u094d\u0932\u094d\u092f\u0942, \u092e\u093f\u0932\u0930 \u0921\u0940\u091f\u0940, \u0917\u0949\u0930\u094d\u0921\u0928 \u090f\u0932\u092c\u0940, \u091a\u094b \u0935\u093e\u092f\u091c\u0947, \u0938\u093f\u0932\u094d\u0935\u0947\u0930\u093e \u0935\u094d\u0939\u0940\u090f\u092e, \u091c\u093f\u0913\u092c\u0940-\u0939\u0930\u094d\u0921\u0930 \u090f, \u0928\u094d\u092f\u0942\u092c\u0930\u094d\u0917 \u0921\u0940, \u0915\u094d\u0932\u0947\u0928\u092e\u0928 \u090f\u092e\u0908. <i>\u0928\u094d\u092f\u0942\u0930\u094b\u0932\u0949\u091c\u0940<\/i>. 2013 \u091c\u0941\u0932\u0948 30;81(5):427-30. doi: 10.1212\/WNL.0b013e31829d85c0. Epub 2013 \u091c\u0942\u0928 28.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23179651\"><b>\u0907\u092e\u0947\u091c\u093f\u0902\u0917<\/b>\u00a0<b>\u0935\u0948\u0936\u093f\u0937\u094d\u091f\u094d\u092f\u0947<\/b>\u00a0\u091a\u094d\u092f\u093e\u00a0<b>\u0938\u0947\u0930\u0947\u092c\u094d\u0930\u094b\u0935\u094d\u0939\u0938\u094d\u0915\u0941\u0932\u0930<\/b>\u00a0<b>\u0906\u0930\u094d\u091f\u093f\u0930\u093f\u0913\u092a\u0945\u0925\u0940<\/b>\u00a0\u0906\u0923\u093f\u00a0<b>\u0938\u094d\u091f\u094d\u0930\u094b\u0915<\/b>\u00a0\u0939\u091a\u093f\u0928\u094d\u0938\u0928-\u0917\u093f\u0932\u092b\u094b\u0930\u094d\u0921 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0938\u093f\u0902\u0921\u094d\u0930\u094b\u092e\u092e\u0927\u094d\u092f\u0947.<\/a> Silvera VM, Gordon LB, Orbach DB, Campbell SE, Machan JT, Ulrich NJ.<br \/><i>AJNR Am J Neuroradiol<\/i>. 2013 \u092e\u0947;34(5):1091-7. doi: 10.3174\/ajnr.A3341. Epub 2012 \u0928\u094b\u0935\u094d\u0939\u0947\u0902\u092c\u0930 22.<\/p>\n<p class=\"desc\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22460337\"><b>\u0915\u094d\u0930\u0945\u0928\u093f\u0913\u092b\u0947\u0936\u093f\u092f\u0932 \u0935\u093f\u0915\u0943\u0924\u0940<\/b>\u00a0\u092e\u0927\u094d\u092f\u0947\u00a0<b>\u0939\u091a\u093f\u0928\u094d\u0938\u0928<\/b>-\u0917\u093f\u0932\u092b\u094b\u0930\u094d\u0921 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0938\u093f\u0902\u0921\u094d\u0930\u094b\u092e.<br \/><\/a>\u0909\u0932\u0930\u093f\u091a \u090f\u0928\u091c\u0947, \u0938\u093f\u0932\u094d\u0935\u0947\u0930\u093e \u0935\u094d\u0939\u0940\u090f\u092e, \u0915\u0945\u092e\u094d\u092a\u092c\u0947\u0932 \u090f\u0938\u0908, \u0917\u0949\u0930\u094d\u0921\u0928 \u090f\u0932\u092c\u0940. <i>AJNR Am J Neuroradiol<\/i>. 2012 \u0938\u092a\u094d\u091f\u0947\u0902\u092c\u0930;33(8):1512-8. doi: 10.3174\/ajnr.A3088. Epub 2012 \u092e\u093e\u0930\u094d\u091a 29.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23012407\"><b>\u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u091a\u093e\u091a\u0923\u0940<\/b>\u00a0\u091a\u094d\u092f\u093e a\u00a0<b>farnesyltransferase<\/b>\u00a0<b>\u0905\u0935\u0930\u094b\u0927\u0915<\/b>\u00a0\u092e\u0927\u094d\u092f\u0947\u00a0<b>\u092e\u0941\u0932\u0947<\/b>\u00a0\u0938\u0939\u00a0<b>\u0939\u091a\u093f\u0928\u094d\u0938\u0928<\/b>-\u0917\u093f\u0932\u092b\u094b\u0930\u094d\u0921 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0938\u093f\u0902\u0921\u094d\u0930\u094b\u092e.<\/a> \u0917\u0949\u0930\u094d\u0921\u0928 \u090f\u0932\u092c\u0940, \u0915\u094d\u0932\u0947\u0928\u092e\u0928 \u090f\u092e\u0908, \u092e\u093f\u0932\u0930 \u0921\u0940\u091f\u0940, \u0928\u094d\u092f\u0942\u092c\u0930\u094d\u0917 \u0921\u0940\u090f\u0938, \u091c\u093f\u0913\u092c\u0940-\u0939\u0930\u094d\u0921\u0930 \u090f, \u0917\u0947\u0930\u0939\u093e\u0930\u094d\u0921-\u0939\u0930\u094d\u092e\u0928 \u090f\u092e, \u0938\u094d\u092e\u0942\u091f \u090f\u0932\u092c\u0940, \u0917\u0949\u0930\u094d\u0921\u0928 \u0938\u0940\u090f\u092e, \u0915\u094d\u0932\u0940\u0935\u094d\u0939\u0932\u0901\u0921 \u0906\u0930, \u0938\u094d\u0928\u093e\u092f\u0921\u0930 \u092c\u0940\u0921\u0940, \u092b\u094d\u0932\u093f\u0917\u094b\u0930 \u092c\u0940, \u092c\u093f\u0936\u092a \u0921\u092c\u094d\u0932\u094d\u092f\u0942\u0906\u0930, \u0938\u094d\u091f\u0945\u091f\u0915\u0947\u0935\u093f\u091a \u092a\u0940, \u0930\u0947\u0917\u0947\u0928 \u090f, \u0938\u094b\u0928\u093f\u0938 \u090f, \u0930\u093f\u0932\u0947 S, Ploski C, Correia A, Quinn N, Ulrich NJ, \u0928\u093e\u091d\u0930\u093f\u092f\u0928 \u090f, \u0932\u093f\u0906\u0902\u0917 \u090f\u092e\u091c\u0940, \u0939\u0941\u0939 \u090f\u0938\u0935\u093e\u092f, \u0936\u094d\u0935\u093e\u0930\u094d\u091f\u091d\u092e\u0928 \u090f, \u0915\u093f\u0930\u0928 \u090f\u092e\u0921\u092c\u094d\u0932\u094d\u092f\u0942. <i>Proc Natl Acad Sci USA<\/i>. 2012 \u0911\u0915\u094d\u091f\u094b\u092c\u0930 9;109(41):16666-71. doi: 10.1073\/pnas.1202529109. Epub 2012 \u0938\u092a\u094d\u091f\u0947\u0902 24<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22083160\"><b>\u092f\u0902\u0924\u094d\u0930\u0923\u093e<\/b>\u00a0\u091a\u094d\u092f\u093e\u00a0<b>\u0905\u0915\u093e\u0932\u0940<\/b>\u00a0<b>\u0930\u0915\u094d\u0924\u0935\u0939\u093f\u0928\u094d\u092f\u093e\u0938\u0902\u092c\u0902\u0927\u0940\u091a\u093e<\/b>\u00a0<b>\u0935\u0943\u0926\u094d\u0927\u0924\u094d\u0935<\/b>\u00a0\u092e\u0927\u094d\u092f\u0947\u00a0<b>\u092e\u0941\u0932\u0947<\/b>\u00a0\u0938\u0939\u00a0<b>\u0939\u091a\u093f\u0928\u094d\u0938\u0928<\/b>-\u0917\u093f\u0932\u092b\u094b\u0930\u094d\u0921 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0938\u093f\u0902\u0921\u094d\u0930\u094b\u092e.<\/a> \u0917\u0947\u0930\u0939\u093e\u0930\u094d\u0921-\u0939\u0930\u094d\u092e\u0928 \u090f\u092e, \u0938\u094d\u092e\u0942\u091f \u090f\u0932\u092c\u0940, \u0935\u0947\u0915 \u090f\u0928, \u0915\u093f\u0930\u0928 \u090f\u092e\u0921\u092c\u094d\u0932\u094d\u092f\u0942, \u0915\u094d\u0932\u0947\u0928\u092e\u0928 \u090f\u092e\u0908, \u092e\u093f\u0932\u0930 \u0921\u0940\u091f\u0940, \u0936\u094d\u0935\u093e\u0930\u094d\u091f\u091d\u092e\u0928 \u090f, \u091c\u093f\u0913\u092c\u0940-\u0939\u0930\u094d\u0921\u0930 \u090f, \u0928\u094d\u092f\u0942\u092c\u0930\u094d\u0917 \u0921\u0940, \u0917\u0949\u0930\u094d\u0921\u0928 \u090f\u0932\u092c\u0940. <i>\u0909\u091a\u094d\u091a \u0930\u0915\u094d\u0924\u0926\u093e\u092c<\/i>. 2012 \u091c\u093e\u0928\u0947\u0935\u093e\u0930\u0940;59(1):92-7. doi: 10.1161\/\u0939\u093e\u092f\u092a\u0930\u091f\u0947\u0928\u094d\u0936\u0928\u0939\u093e.111.180919. Epub 2011 \u0928\u094b\u0935\u094d\u0939\u0947\u0902\u092c\u0930 14.<\/p>\n<p class=\"desc\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22752073\"><strong>\u0939\u091a\u093f\u0928\u094d\u0938\u0928-\u0917\u093f\u0932\u092b\u094b\u0930\u094d\u0921 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0938\u093f\u0902\u0921\u094d\u0930\u094b\u092e\u092e\u0927\u0940\u0932 \u0930\u0947\u0921\u093f\u092f\u094b\u0917\u094d\u0930\u093e\u092b\u093f\u0915 \u0905\u092d\u093f\u0935\u094d\u092f\u0915\u094d\u0924\u0940\u0902\u091a\u093e \u0938\u0902\u092d\u093e\u0935\u094d\u092f \u0905\u092d\u094d\u092f\u093e\u0938.<\/strong><br \/><\/a>Cleveland RH, Gordon LB, Kleinman ME, Miller DT, Gordon CM, Snyder BD, Nazarian A, Giobbie-Hurder A, Neuberg D, Kieran MW. <i>\u092a\u0947\u0921\u093f\u092f\u093e\u091f\u0930 \u0930\u0947\u0921\u093f\u0913\u0932<\/i>. 2012 \u0938\u092a\u094d\u091f\u0947\u0902\u092c\u0930;42(9):1089-98. doi: 10.1007\/s00247-012-2423-1. Epub 2012 \u091c\u0941\u0932\u0948 1.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21980471\"><b>\u0915\u092e\u0940<\/b>\u00a0\u0906\u0923\u093f\u00a0<b>\u0909\u091a\u094d\u091a<\/b>\u00a0<b>\u0935\u094d\u092f\u0915\u094d\u0924 \u0915\u0930\u0923\u0947<\/b>\u00a0<b>alleles<\/b>\u00a0\u090f\u0932\u090f\u092e\u090f\u0928\u090f \u091c\u0940\u0928: \u0932\u0945\u092e\u093f\u0928\u094b\u092a\u0945\u0925\u0940 \u0930\u094b\u0917\u093e\u091a\u094d\u092f\u093e \u0935\u093f\u0915\u093e\u0938\u093e\u0938\u093e\u0920\u0940 \u092a\u0930\u093f\u0923\u093e\u092e.<\/a> \u0930\u0949\u0921\u094d\u0930\u093f\u0917\u094d\u091c \u090f\u0938, \u090f\u0930\u093f\u0915\u094d\u0938\u0928 \u090f\u092e. <i>\u092a\u0940\u090f\u0932\u0913\u090f\u0938 \u0935\u0928<\/i>. 2011;6(9):e25472. doi: 10.1371\/journal.pone.0025472. Epub 2011 \u0938\u092a\u094d\u091f\u0947\u0902\u092c\u0930 29.<br \/><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21445982\"><b><br \/>\u0939\u091a\u093f\u0928\u094d\u0938\u0928-\u0917\u093f\u0932\u092b\u094b\u0930\u094d\u0921<\/b>\u00a0<b>\u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e<\/b>\u00a0\u0906\u0939\u0947\u00a0<b>\u0915\u0902\u0915\u093e\u0932<\/b>\u00a0\u0921\u093f\u0938\u092a\u094d\u0932\u0947\u0938\u0940\u092f\u093e<\/a> Gordon CM, Gordon LB, Snyder BD, Nazarian A, Quinn N, Huh S, Giobbie-Hurder A, Neuberg D, Cleveland R, Kleinman M, Miller DT, Kieran MW. <i>\u091c\u0947 \u092c\u094b\u0928 \u092e\u093e\u092f\u0928\u0930 \u0930\u093e<\/i>. 2011 \u091c\u0941\u0932\u0948;26(7):1670-9. doi: 10.1002\/jbmr.392.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20798379\"><b>\u0939\u0943\u0926\u092f \u0935 \u0930\u0915\u094d\u0924\u0935\u093e\u0939\u093f\u0928\u094d\u092f\u093e\u0938\u0902\u092c\u0902\u0927\u0940 \u092a\u0945\u0925\u0949\u0932\u0949\u091c\u0940<\/b>\u00a0\u092e\u0927\u094d\u092f\u0947\u00a0<b>\u0939\u091a\u093f\u0928\u094d\u0938\u0928<\/b>-\u0917\u093f\u0932\u092b\u094b\u0930\u094d\u0921 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e: \u0930\u0915\u094d\u0924\u0935\u0939\u093f\u0928\u094d\u092f\u093e\u0936\u0940 \u0938\u0939\u0938\u0902\u092c\u0902\u0927<b>\u092a\u0945\u0925\u0949\u0932\u0949\u091c\u0940<\/b>\u00a0\u0935\u0943\u0926\u094d\u0927\u0924\u094d\u0935.<\/a> \u0911\u0932\u093f\u0935\u094d\u0939 \u090f\u092e, \u0939\u093e\u0930\u094d\u091f\u0947\u0928 I, \u092e\u093f\u0936\u0947\u0932 \u0906\u0930, \u092c\u093f\u092f\u0930\u094d\u0938 \u091c\u0947\u0915\u0947, \u091c\u093e\u092c\u093e\u0932\u0940 \u0915\u0947, \u0915\u093e\u0913 \u0915\u0947, \u090f\u0930\u094d\u0921\u094b\u0938 \u090f\u092e\u0906\u0930, \u092c\u094d\u0932\u0947\u0905\u0930 \u0938\u0940, \u092b\u0902\u0915\u0947 \u092c\u0940, \u0938\u094d\u092e\u0942\u091f \u090f\u0932, \u0917\u0947\u0930\u094d\u0939\u093e\u0930\u094d\u0921-\u0939\u0930\u094d\u092e\u0928 \u090f\u092e, \u092e\u091a\u093e\u0928 \u091c\u0947\u091f\u0940, \u0915\u0941\u091f\u0940\u0938 \u0906\u0930, \u0935\u093f\u0930\u092e\u093e\u0928\u0940 \u0906\u0930, \u0915\u0949\u0932\u093f\u0928\u094d\u0938 \u090f\u092b\u090f\u0938, \u0935\u094d\u0939\u093e\u0907\u091f \u091f\u0940\u090f\u0928, \u0928\u0947\u092c\u0947\u0932 \u0908\u091c\u0940, \u0917\u0949\u0930\u094d\u0921\u0928 \u090f\u0932\u092c\u0940. <i>\u0906\u0930\u094d\u091f\u0947\u0930\u093f\u0913\u0938\u094d\u0915\u0932\u0930 \u0925\u094d\u0930\u094b\u092e\u094d\u092c \u0935\u094d\u0939\u0945\u0938\u094d\u0915 \u092c\u093e\u092f\u094b\u0932<\/i>. 2010 \u0928\u094b\u0935\u094d\u0939\u0947\u0902;30(11):2301-9. doi: 10.1161\/ATVBAHA.110.209460. Epub 2010 \u0911\u0917\u0938\u094d\u091f 26.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19236595\"><b>\u0939\u091a\u093f\u0928\u094d\u0938\u0928-\u0917\u093f\u0932\u092b\u094b\u0930\u094d\u0921<\/b>\u00a0<b>\u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e<\/b>\u00a0<b>\u0938\u093f\u0902\u0921\u094d\u0930\u094b\u092e<\/b>:\u00a0<b>\u0924\u094b\u0902\u0921\u0940<\/b>\u00a0\u0906\u0923\u093f \u0915\u094d\u0930\u0945\u0928\u093f\u0913\u092b\u0947\u0938\u093f\u092f\u0932 \u092b\u0947\u0928\u094b\u091f\u093e\u0907\u092a.<\/a> Domingo DL, Trujillo MI, Council SE, Merideth MA, Gordon LB, Wu T, Introne WJ, Gahl WA, Hart TC. <i>\u0924\u094b\u0902\u0921\u0940<\/i><i>\u00a0<\/i><i>\u091c\u093f<\/i>. 2009 \u090f\u092a\u094d\u0930\u093f\u0932;15(3):187-95. doi: 10.1111\/j.1601-0825.2009.01521.x. Epub 2009 \u092b\u0947\u092c\u094d\u0930\u0941\u0935\u093e\u0930\u0940 19.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18334552\"><b>\u0932\u0915\u094d\u0937\u094d\u092f \u0915\u0947\u0932\u0947<\/b>\u00a0<b>\u091f\u094d\u0930\u093e\u0928\u094d\u0938\u091c\u0947\u0928\u093f\u0915<\/b>\u00a0<b>\u0905\u092d\u093f\u0935\u094d\u092f\u0915\u094d\u0924\u0940<\/b>\u00a0\u091a\u094d\u092f\u093e\u00a0<b>\u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928<\/b>\u00a0<b>\u0915\u093e\u0930\u0923\u0940\u092d\u0942\u0924<\/b>\u00a0\u0939\u091a\u093f\u0928\u094d\u0938\u0928-\u0917\u093f\u0932\u092b\u094b\u0930\u094d\u0921 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0938\u093f\u0902\u0921\u094d\u0930\u094b\u092e\u092e\u0941\u0933\u0947 \u092a\u094d\u0930\u094b\u0932\u093f\u092b\u0947\u0930\u0947\u091f\u093f\u0935\u094d\u0939 \u0906\u0923\u093f \u0921\u0940\u091c\u0928\u0930\u0947\u091f\u093f\u0935\u094d\u0939 \u090f\u092a\u093f\u0921\u0930\u094d\u092e\u0932 \u0930\u094b\u0917 \u0939\u094b\u0924\u094b.<\/a> \u0938\u0947\u0917\u0947\u0932\u093f\u092f\u0938 \u090f\u091a, \u0930\u094b\u0938\u0947\u0928\u0917\u093e\u0930\u094d\u0921\u094d\u091f\u0928 \u0935\u093e\u0908, \u0939\u0928\u0940\u092b \u090f\u092e, \u090f\u0930\u094d\u0921\u094b\u0938 \u090f\u092e\u0906\u0930, \u0930\u094b\u091d\u0947\u0932 \u092c\u0940, \u0915\u0949\u0932\u093f\u0928\u094d\u0938 \u090f\u092b\u090f\u0938, \u090f\u0930\u093f\u0915\u094d\u0938\u0928 \u090f\u092e. <i>\u091c\u0947 \u0938\u0947\u0932 \u0938\u093e\u092f\u0928\u094d\u0938<\/i>. 2008 \u090f\u092a\u094d\u0930\u093f\u0932 1;121(\u092a\u0902. 7):969-78. doi: 10.1242\/jcs.022913. Epub 2008 \u092e\u093e\u0930\u094d\u091a 11.<\/p>\n<p class=\"desc\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18708427\"><b>\u0909\u0932\u091f \u0915\u0930\u0923\u094d\u092f\u093e\u092f\u094b\u0917\u094d\u092f<\/b>\u00a0<b>\u092b\u0947\u0928\u094b\u091f\u093e\u0907\u092a<\/b>\u00a0a \u092e\u0927\u094d\u092f\u0947\u00a0<b>\u0909\u0902\u0926\u0940\u0930<\/b>\u00a0\u0939\u091a\u093f\u0928\u094d\u0938\u0928-\u0917\u093f\u0932\u092b\u094b\u0930\u094d\u0921 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0938\u093f\u0902\u0921\u094d\u0930\u094b\u092e\u091a\u0947 \u092e\u0949\u0921\u0947\u0932.<br \/><\/a>\u0938\u0947\u0917\u0947\u0932\u093f\u092f\u0938 \u090f\u091a, \u0930\u094b\u0938\u0947\u0928\u0917\u093e\u0930\u094d\u0921\u0928 \u0935\u093e\u0908, \u0936\u094d\u092e\u093f\u091f \u0908, \u0938\u094b\u0928\u093e\u092c\u0947\u0902\u0921 \u0938\u0940, \u0930\u094b\u091d\u0947\u0932 \u092c\u0940, \u090f\u0930\u093f\u0915\u094d\u0938\u0928 \u090f\u092e. <i>\u091c\u0947 \u092e\u0947\u0921 \u091c\u0947\u0928\u0947\u091f<\/i>. 2008 \u0921\u093f\u0938\u0947\u0902\u092c\u0930;45(12):794-801. doi: 10.1136\/jmg.2008.060772. Epub 2008 \u0911\u0917\u0938\u094d\u091f 15.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18256394\"><b>\u092b\u0947\u0928\u094b\u091f\u093e\u0907\u092a<\/b>\u00a0\u0906\u0923\u093f\u00a0<b>\u0905\u092d\u094d\u092f\u093e\u0938\u0915\u094d\u0930\u092e<\/b>\u00a0\u091a\u094d\u092f\u093e\u00a0<b>\u0939\u091a\u093f\u0928\u094d\u0938\u0928<\/b>-\u0917\u093f\u0932\u092b\u094b\u0930\u094d\u0921 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0938\u093f\u0902\u0921\u094d\u0930\u094b\u092e.<\/a> \u092e\u0947\u0930\u093f\u0921\u0947\u0925 \u090f\u092e\u090f, \u0917\u0949\u0930\u094d\u0921\u0928 \u090f\u0932\u092c\u0940, \u0915\u094d\u0932\u0949\u0938 \u090f\u0938, \u0938\u091a\u0926\u0947\u0935 \u0935\u094d\u0939\u0940, \u0938\u094d\u092e\u093f\u0925 \u090f\u0938\u0940, \u092a\u0947\u0930\u0940 \u090f\u092e\u092c\u0940, \u092c\u094d\u0930\u0947\u0935\u0930 \u0938\u0940\u0938\u0940, \u091d\u093e\u0932\u0947\u0935\u094d\u0938\u094d\u0915\u0940 \u0938\u0940, \u0915\u093f\u092e \u090f\u091a\u091c\u0947, \u0938\u0949\u0932\u094b\u092e\u0928 \u092c\u0940, \u092c\u094d\u0930\u0942\u0915\u094d\u0938 \u092c\u0940\u092a\u0940, \u0917\u0947\u0930\u094d\u092c\u0930 \u090f\u0932\u090f\u091a, \u091f\u0930\u094d\u0928\u0930 \u090f\u092e\u090f\u0932, \u0921\u094b\u092e\u093f\u0902\u0917\u094b \u0921\u0940\u090f\u0932, \u0939\u093e\u0930\u094d\u091f \u091f\u0940\u0938\u0940, \u0917\u094d\u0930\u093e\u092b \u091c\u0947, \u0930\u0947\u0928\u0949\u0932\u094d\u0921\u094d\u0938 \u091c\u0947\u0938\u0940 , Gropman A, Yanovski JA, Gerhard-Herman M, Collins FS, Nabel EG, Cannon RO 3rd, Gahl WA, Introne WJ. <i>\u090f\u0928 \u0907\u0902\u0917\u094d\u0932\u093f\u0936 \u091c\u0947 \u092e\u0947\u0921<\/i>. 2008 \u092b\u0947\u092c\u094d\u0930\u0941\u0935\u093e\u0930\u0940 7;358(6):592-604. doi: 10.1056\/NEJMoa0706898.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17908771\"><b>\u0928\u0935\u0940\u0928<\/b>\u00a0<b>\u0926\u0943\u0937\u094d\u091f\u0940\u0915\u094b\u0928<\/b>\u00a0\u0915\u0930\u0923\u094d\u092f\u093e\u0938\u093e\u0920\u0940\u00a0<b>\u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e<\/b>.<\/a> Kieran MW, Gordon L, Kleinman M. Pediatrics. 2007 \u0911\u0915\u094d\u091f\u094b\u092c\u0930;120(4):834-41. \u092a\u0941\u0928\u0930\u093e\u0935\u0932\u094b\u0915\u0928 \u0915\u0930\u093e. \u092e\u0927\u094d\u092f\u0947 \u0924\u094d\u0930\u0941\u091f\u0940: <i>\u092c\u093e\u0932\u0930\u094b\u0917<\/i>. 2007 \u0921\u093f\u0938\u0947\u0902\u092c\u0930;120(6):1405.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17908770\"><b>\u0930\u094b\u0917\u093e\u091a\u0940 \u092a\u094d\u0930\u0917\u0924\u0940<\/b>\u00a0\u092e\u0927\u094d\u092f\u0947\u00a0<b>\u0939\u091a\u093f\u0928\u094d\u0938\u0928-\u0917\u093f\u0932\u092b\u094b\u0930\u094d\u0921<\/b>\u00a0\u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0938\u093f\u0902\u0921\u094d\u0930\u094b\u092e: \u0935\u093e\u0922 \u0906\u0923\u093f \u0935\u093f\u0915\u093e\u0938\u093e\u0935\u0930 \u092a\u0930\u093f\u0923\u093e\u092e.<\/a> \u0917\u0949\u0930\u094d\u0921\u0928 \u090f\u0932\u092c\u0940, \u092e\u0945\u0915\u0915\u093e\u0930\u094d\u091f\u0928 \u0915\u0947\u090f\u092e, \u091c\u093f\u0913\u092c\u0940-\u0939\u0930\u094d\u0921\u0930 \u090f, \u092e\u093e\u091a\u093e\u0928 \u091c\u0947\u091f\u0940, \u0915\u0945\u092e\u094d\u092a\u092c\u0947\u0932 \u090f\u0938\u0908, \u092c\u0930\u094d\u0928\u094d\u0938 \u090f\u0938\u0921\u0940, \u0915\u093f\u0930\u0928 MW. <i>\u092c\u093e\u0932\u0930\u094b\u0917<\/i>. 2007 \u0911\u0915\u094d\u091f\u094b\u092c\u0930;120(4):824-33.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15756215\"><b>\u0915\u092e\u0940 \u0915\u0947\u0932\u0947<\/b>\u00a0<b>\u090d\u0921\u093f\u092a\u094b\u0928\u0947\u0915\u094d\u091f\u093f\u0928<\/b>\u00a0\u0906\u0923\u093f\u00a0<b>\u090f\u091a\u0921\u0940\u090f\u0932 \u0915\u094b\u0932\u0947\u0938\u094d\u091f\u094d\u0930\u0949\u0932<\/b>\u00a0\u0936\u093f\u0935\u093e\u092f\u00a0<b>\u092d\u093e\u0930\u0926\u0938\u094d\u0924<\/b>\u00a0<b>\u0938\u0940-\u092a\u094d\u0930\u0924\u093f\u0915\u094d\u0930\u093f\u092f\u093e\u0936\u0940\u0932 \u092a\u094d\u0930\u0925\u093f\u0928\u0947<\/b>: \u0939\u091a\u093f\u0928\u094d\u0938\u0928-\u0917\u093f\u0932\u092b\u094b\u0930\u094d\u0921 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0938\u093f\u0902\u0921\u094d\u0930\u094b\u092e\u092e\u0927\u0940\u0932 \u0905\u0915\u093e\u0932\u0940 \u090f\u0925\u0947\u0930\u094b\u0938\u094d\u0915\u094d\u0932\u0947\u0930\u094b\u0938\u093f\u0938\u091a\u094d\u092f\u093e \u091c\u0940\u0935\u0936\u093e\u0938\u094d\u0924\u094d\u0930\u093e\u091a\u0947 \u0938\u0902\u0915\u0947\u0924.<\/a> \u0917\u0949\u0930\u094d\u0921\u0928 LB, Harten IA, Patti ME, Lichtenstein AH. <i>\u091c\u0947 \u092a\u0947\u0921\u093f\u092f\u093e\u091f\u0930<\/i>. 2005 \u092e\u093e\u0930\u094d\u091a;146(3):336-41.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16129833\"><b>\u092a\u094d\u0930\u0924\u093f\u092c\u0902\u0927 \u0915\u0930\u0923\u093e\u0930\u093e<\/b>\u00a0<b>farnesylation<\/b>\u00a0\u0911\u092b \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u0928 \u0939\u091a\u093f\u0928\u094d\u0938\u0928-\u0917\u093f\u0932\u092b\u094b\u0930\u094d\u0921\u091a\u094d\u092f\u093e \u0935\u0948\u0936\u093f\u0937\u094d\u091f\u094d\u092f\u092a\u0942\u0930\u094d\u0923 \u0906\u0923\u094d\u0935\u093f\u0915 \u092c\u094d\u0932\u0947\u092c\u093f\u0902\u0917\u0932\u093e \u092a\u094d\u0930\u0924\u093f\u092c\u0902\u0927\u093f\u0924 \u0915\u0930\u0924\u0947\u00a0<b>\u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e<\/b>\u00a0\u0938\u093f\u0902\u0921\u094d\u0930\u094b\u092e<\/a> \u0915\u0945\u092a\u0947\u0932 \u092c\u0940\u0938\u0940, \u090f\u0930\u094d\u0921\u094b\u0938 \u090f\u092e\u0906\u0930, \u092e\u0945\u0921\u093f\u0917\u0928 \u091c\u0947\u092a\u0940, \u092b\u093f\u0913\u0930\u094d\u0921\u0932\u093f\u0938\u0940 \u091c\u0947\u091c\u0947, \u0935\u0930\u094d\u0917\u093e \u0906\u0930, \u0915\u094b\u0928\u0940\u0932\u0940 \u0915\u0947\u090f\u0928, \u0917\u0949\u0930\u094d\u0921\u0928 \u090f\u0932\u092c\u0940, \u0921\u0947\u0930 \u0938\u0940\u091c\u0947, \u0915\u0949\u0915\u094d\u0938 \u090f\u0921\u0940, \u0915\u0949\u0932\u093f\u0928\u094d\u0938 \u090f\u092b\u090f\u0938. <i>Proc Natl Acad Sci USA<\/i>. 2005 \u0938\u092a\u094d\u091f\u0947\u0902\u092c\u0930 6;102(36):12879-84. Epub 2005 \u0911\u0917\u0938\u094d\u091f 29<\/p>\n<p class=\"details\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15184648\"><b>\u091c\u092e\u093e<\/b>\u00a0\u091a\u094d\u092f\u093e\u00a0<b>\u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0940<\/b>\u00a0<b>\u0932\u0945\u092e\u093f\u0928 \u090f<\/b>\u00a0<b>\u0915\u093e\u0930\u0923\u0947<\/b>\u00a0\u0939\u091a\u093f\u0928\u094d\u0938\u0928-\u0917\u093f\u0932\u092b\u094b\u0930\u094d\u0921 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0938\u093f\u0902\u0921\u094d\u0930\u094b\u092e\u092e\u0927\u094d\u092f\u0947 \u0906\u0923\u094d\u0935\u093f\u0915 \u0906\u0930\u094d\u0915\u093f\u091f\u0947\u0915\u094d\u091a\u0930\u092e\u0927\u094d\u092f\u0947 \u092a\u094d\u0930\u0917\u0924\u0940\u0936\u0940\u0932 \u092c\u0926\u0932.<\/a> \u0917\u094b\u0932\u094d\u0921\u092e\u0928 \u0906\u0930\u0921\u0940, \u0936\u0941\u092e\u093e\u0915\u0930 \u0921\u0940\u0915\u0947, \u090f\u0930\u094d\u0921\u094b\u0938 \u090f\u092e\u0906\u0930, \u090f\u0930\u093f\u0915\u094d\u0938\u0928 \u090f\u092e, \u0917\u094b\u0932\u094d\u0921\u092e\u0928 \u090f\u0908, \u0917\u0949\u0930\u094d\u0921\u0928 \u090f\u0932\u092c\u0940, \u0917\u094d\u0930\u0941\u090f\u0928\u092c\u0949\u092e \u0935\u093e\u0908, \u0916\u0941\u0913\u0928 \u090f\u0938, \u092e\u0947\u0902\u0921\u0947\u091d \u090f\u092e, \u0935\u0930\u094d\u0917\u093e \u0906\u0930, \u0915\u0949\u0932\u093f\u0928\u094d\u0938 \u090f\u092b\u090f\u0938. <i>Proc Natl Acad Sci USA<\/i>. 2004 \u091c\u0942\u0928 15;101(24):8963-8. Epub 2004 \u091c\u0942\u0928 7.<\/p>\n<h4><strong>\u092a\u0941\u0938\u094d\u0924\u0915\u0947 \u0906\u0923\u093f \u0915\u093e\u0917\u0926\u092a\u0924\u094d\u0930\u0947<\/strong><\/h4>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20301300\" target=\"_blank\" rel=\"noopener noreferrer\">\u0939\u091a\u093f\u0928\u094d\u0938\u0928-\u0917\u093f\u0932\u092b\u094b\u0930\u094d\u0921 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0938\u093f\u0902\u0921\u094d\u0930\u094b\u092e.<\/a>\u00a0 \u0917\u0949\u0930\u094d\u0921\u0928 \u090f\u0932\u092c\u0940, \u092c\u094d\u0930\u093e\u0909\u0928 \u0921\u092c\u094d\u0932\u094d\u092f\u0942\u091f\u0940, \u0915\u0949\u0932\u093f\u0928\u094d\u0938 \u090f\u092b\u090f\u0938. \u092e\u0927\u094d\u092f\u0947: Pagon RA, Bird TD, Dolan CR, Stephens K, \u0938\u0902\u092a\u093e\u0926\u0915. GeneReviews [\u0907\u0902\u091f\u0930\u0928\u0947\u091f]. \u0938\u093f\u090f\u091f\u0932 (WA): \u0935\u0949\u0936\u093f\u0902\u0917\u094d\u091f\u0928 \u0935\u093f\u0926\u094d\u092f\u093e\u092a\u0940\u0920, \u0938\u093f\u090f\u091f\u0932; 1993-.<br \/>2003 \u0921\u093f\u0938\u0947\u0902\u092c\u0930 12 [\u0905\u0926\u094d\u092f\u0924\u0928\u093f\u0924 2011 \u091c\u093e\u0928\u0947\u0935\u093e\u0930\u0940 06].<\/p>\n<div class=\"wpb_text_column wpb_content_element\">\n<div class=\"wpb_wrapper\">\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20301300\" target=\"_blank\" rel=\"noopener noreferrer\">\u0939\u091a\u093f\u0928\u094d\u0938\u0928-\u0917\u093f\u0932\u092b\u094b\u0930\u094d\u0921 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0938\u093f\u0902\u0921\u094d\u0930\u094b\u092e.<\/a>\u00a0 \u0917\u0949\u0930\u094d\u0921\u0928 \u090f\u0932\u092c\u0940, \u092c\u094d\u0930\u093e\u0909\u0928 \u0921\u092c\u094d\u0932\u094d\u092f\u0942\u091f\u0940, \u0915\u0949\u0932\u093f\u0928\u094d\u0938 \u090f\u092b\u090f\u0938. \u092e\u0927\u094d\u092f\u0947: Pagon RA, Bird TD, Dolan CR, Stephens K, \u0938\u0902\u092a\u093e\u0926\u0915. GeneReviews [\u0907\u0902\u091f\u0930\u0928\u0947\u091f]. \u0938\u093f\u090f\u091f\u0932 (WA): \u0935\u0949\u0936\u093f\u0902\u0917\u094d\u091f\u0928 \u0935\u093f\u0926\u094d\u092f\u093e\u092a\u0940\u0920, \u0938\u093f\u090f\u091f\u0932; 1993-.<br \/>2003 \u0921\u093f\u0938\u0947\u0902\u092c\u0930 12 [\u0905\u0926\u094d\u092f\u0924\u0928\u093f\u0924 2011 \u091c\u093e\u0928\u0947\u0935\u093e\u0930\u0940 06].<\/p>\n<p>\u0905\u0915\u093e\u0932\u0940 \u0935\u0943\u0926\u094d\u0927\u0924\u094d\u0935 \u0938\u093f\u0902\u0921\u094d\u0930\u094b\u092e \u0939\u091a\u093f\u0928\u094d\u0938\u0928-\u0917\u093f\u0932\u092b\u094b\u0930\u094d\u0921 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e: \u0938\u093e\u092e\u093e\u0928\u094d\u092f \u0935\u0943\u0926\u094d\u0927\u0924\u094d\u0935\u093e\u091a\u0940 \u0905\u0902\u0924\u0930\u094d\u0926\u0943\u0937\u094d\u091f\u0940. \u0917\u0949\u0930\u094d\u0921\u0928, \u0932\u0947\u0938\u094d\u0932\u0940. \u091a\u094d\u092f\u093e 7 \u0935\u094d\u092f\u093e \u0906\u0935\u0943\u0924\u094d\u0924\u0940\u0924\u0940\u0932 \u092a\u094d\u0930\u0915\u0930\u0923\u00a0<em>\u092c\u094d\u0930\u094b\u0915\u0932\u0939\u0930\u094d\u0938\u094d\u091f\u091a\u0947 \u091c\u0947\u0930\u093f\u092f\u093e\u091f\u094d\u0930\u093f\u0915 \u092e\u0947\u0921\u093f\u0938\u093f\u0928 \u0906\u0923\u093f \u091c\u0947\u0930\u094b\u0928\u094d\u091f\u094b\u0932\u0949\u091c\u0940\u091a\u0947 \u092a\u093e\u0920\u094d\u092f\u092a\u0941\u0938\u094d\u0924\u0915<\/em>. \u0915\u0949\u092a\u0940\u0930\u093e\u0907\u091f: 2010.<\/p>\n<p><em>LMNA<\/em>\u00a0\u0906\u0923\u093f \u0939\u091a\u093f\u0928\u094d\u0938\u0928-\u0917\u093f\u0932\u092b\u094b\u0930\u094d\u0921 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0938\u093f\u0902\u0921\u094d\u0930\u094b\u092e \u0906\u0923\u093f \u0905\u0938\u094b\u0938\u093f\u090f\u091f\u0947\u0921 \u0932\u0945\u092e\u093f\u0928\u094b\u092a\u0945\u0925\u0940. \u0917\u0949\u0930\u094d\u0921\u0928 \u090f\u0932\u092c\u0940, \u092c\u094d\u0930\u093e\u0909\u0928 \u0921\u092c\u094d\u0932\u094d\u092f\u0942\u091f\u0940, \u0930\u094b\u0925\u092e\u0928 \u090f\u092b\u091c\u0940.  CJ Epstein, RP Erickson, A. Wynshaw-Boris (Eds.) \u092e\u0927\u094d\u092f\u0947<em>\u00a0\u0935\u093f\u0915\u093e\u0938\u093e\u091a\u094d\u092f\u093e \u091c\u0928\u094d\u092e\u091c\u093e\u0924 \u0924\u094d\u0930\u0941\u091f\u0940: \u092e\u0949\u0930\u094d\u092b\u094b\u091c\u0947\u0928\u0947\u0938\u093f\u0938\u091a\u094d\u092f\u093e \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u0935\u093f\u0915\u093e\u0930\u093e\u0902\u091a\u093e \u0906\u0923\u094d\u0935\u093f\u0915 \u0906\u0927\u093e\u0930<\/em>\u00a0(2<sup>\u090f\u0928\u0921\u0940<\/sup>\u00a0\u090f\u0921.) \u0928\u094d\u092f\u0942\u092f\u0949\u0930\u094d\u0915, \u0928\u094d\u092f\u0942\u092f\u0949\u0930\u094d\u0915: \u0911\u0915\u094d\u0938\u092b\u0930\u094d\u0921 \u092f\u0941\u0928\u093f\u0935\u094d\u0939\u0930\u094d\u0938\u093f\u091f\u0940 \u092a\u094d\u0930\u0947\u0938. 2008 139: 1219-1229.<\/p>\n<\/div>\n<\/div>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][\/et_pb_section][et_pb_section fb_built=\u201d1\u2033 module_class=\u201dfooter\u201d _builder_version=\u2033TP_27=\u201d4.21=\u201dTp_27 \u092a\u093e\u0930\u094d\u0936\u094d\u0935\u092d\u0942\u092e\u0940\u201d9. custom_margin=\u201d-2px|||||\u201d custom_padding=\u201d0|0px|0|0px|false|false\u201d z_index_tablet=\u201d500\u2033 border_width_top=\u201d12px\u201d border_color_top=\u201d#00b2e2\u2033 global_module=\u201d133\u2033 locked=\u201doff\u201d global_colors_p=\u201d][_colors_info] column_structure=\u201d1_4,1_4,1_2\u2033 make_equal=\u201don\u201d module_class=\u201d et_pb_row_fullwidth\u201d _builder_version=\u201d4.16\u2033 width=\u201d89%\u201d width_tablet=\u201d80%\u201d\u201dwidth_thla=\u201dwidth_phone=\u201dwidth_phone=\u201d \u0935\u0930 max_width=\u201d89%\u201d max_width_tablet=\u201d80%\u201d max_width_phone=\u201d\u201dmax_width_last_edited=\u201d\u0911\u0928|\u0921\u0947\u0938\u094d\u0915\u091f\u0949\u092a\u201d z_index_tablet=\u201d500\u2033 make_fullwidth=\u201don\u201d \u0930\u0942\u0902\u0926\u0940_\u092f\u0941\u0928\u093f\u091f=\u201d01 \u092a\u094d\u0930\u0924\u093f \u091f\u0915\u094d\u091f\u201d01 \u092c\u0902\u0926 global_colors_info=\u201d{}\u201d][et_pb_column type=\u201d1_4\u2033 _builder_version=\u201d4.16\u2033 custom_padding=\u201d|||\u201d global_colors_info=\u201d{}\u201d custom_padding__hover=\u201d|||\u201d][et_pb_cta button_url=\u201dhttps:\/\/www.progeriaresearch.org\/newsletter-signup\/\u201d button_text=\u201d\u0906\u0924\u093e \u0938\u093e\u0907\u0928 \u0905\u092a \u0915\u0930\u093e\u201d admin_label=\u201d\u0935\u0943\u0924\u094d\u0924\u092a\u0924\u094d\u0930\u093e\u0938\u093e\u0920\u0940 \u0938\u093e\u0907\u0928 \u0905\u092a \u0915\u0930\u093e\u201d module_class =\u201dsign-btn\u201d _builder_version=\u201d4.16\u2033 header_font_size=\u201d25px\u201d background_color=\u201d#29327a\u201d animation_style=\u201dslide\u201d animation_direction=\u201dleft\u201d animation_intensity_slide=\u201d25%\u201d header_font_size_tablet=\u201d\u201d header_font_size_phone=\u201d30p header_font_size_last_edited=\u201don|desktop\u201d z_index_tablet=\u201d500\u2033 border_radii=\u201don|25px|25px|25px|25px\u201d global_colors_info=\u201d{}\u201d button_bg_color__hover_enabled=\u201dcolor_bg_color__hover_enabled=\u201dor\u201dcolor_tp28\u201dcolor_b08\u201d button_border_color__hover_enabled=\u201d\u091a\u093e\u0932\u0942\u201d]<\/p>\n<h2>\u0938\u093e\u0907\u0928 \u0905\u092a \u0915\u0930\u093e<\/h2>\n<h2>\u0906\u092e\u091a\u094d\u092f\u093e \u0938\u093e\u0920\u0940<\/h2>\n<h2>\u0935\u0943\u0924\u094d\u0924\u092a\u0924\u094d\u0930!<\/h2>\n<p>[\/et_pb_cta][\/et_pb_column][et_pb_column type=\u201d1_4\u2033 _builder_version=\u201d4.16\u2033 custom_padding=\u201d|||\u201d global_colors_info=\u201d{}\u201d custom_padding__hover=\u201d|||\u201d][et_pb_cta button_url=\u201dhttps:\/\/progeriaresearch.donorsupport.co\/-\/XZHJVWZR\u201d button_text=\u201d\u0906\u0924\u093e \u0926\u0947\u0923\u0917\u0940 \u0926\u094d\u092f\u093e\u201d admin_label=\u201d\u090f\u0915\u0924\u094d\u0930\u093f\u0924\u092a\u0923\u0947, \u0906\u092e\u094d\u0939\u0940 \u092c\u0930\u093e \u0936\u094b\u0927\u0942! &quot; module_class=\u201dsign-btn\u201d _builder_version=\u201d4.16\u2033 header_font_size=\u201d25px\u201d background_color=\u201d#29327a\u201d animation_style=\u201dslide\u201d animation_direction=\u201dleft\u201d animation_intensity_slide=\u201dT_font_slide=\u201d251 header=\u201d251 header_font_size_phone=\u201d30px\u201d header_font_size_last_edited=\u201don|desktop\u201d body_font_size_tablet=\u201d\u201d body_font_size_phone=\u201d\u201d body_font_size_last_edited=\u201don|desktop\u201d z_index_tablet=\u201d500\u2033 border_radii=\u201don|25px|25px|25px|25px\u201d global_colors_info=\u201d{}\u201d button_bg_color__hover_enabled=\u201don\u201d button_bg_color__hover=\u201d#8fd2ed\u201d button_border_color__hover_enabled\u201d]=\u201d]<\/p>\n<h2>\u090f\u0915\u0924\u094d\u0930, \u0906\u092e\u094d\u0939\u0940<\/h2>\n<h2><em>\u0939\u094b\u0908\u0932<\/em><\/h2>\n<h2>\u0909\u092a\u091a\u093e\u0930 \u0936\u094b\u0927\u093e!<\/h2>\n<p>[\/et_pb_cta][\/et_pb_column][et_pb_column type=\u201d1_2\u2033 _builder_version=\u201d4.16\u2033 custom_padding=\u201d|||\u201d global_colors_info=\u201d{}\u201d custom_padding__hover=\u201d|||\u201d][et_pb_image src=\u201dhttps:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2023\/06\/2023-footer-strip-5.png\u201d title_text =\u201d\u0968\u0966\u0968\u0969 \u092b\u0942\u091f\u0930 \u0938\u094d\u091f\u094d\u0930\u093f\u092a \u096b\u2033 _builder_version=\u201d4.21.0\u2033 _module_preset=\u201ddefault\u201d custom_margin=\u201d35px||||false|false\u201d global_colors_info=\u201d{}\u201d][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_se]<\/p>","protected":false},"excerpt":{"rendered":"<p>[et_pb_section fb_built=\u201d1\u2033 fullwidth=\u201d\u091a\u093e\u0932\u0942\u201d disabled_on=\u201doff|off|off\u201d _builder_version=\u201d4.16\u2033 border_width_bottom=\u201d55px\u201d border_color_bottom=\u201d#29327a\u201d \u0932\u0949\u0915=\u201d\u092c\u0902\u0926 global_colors_info=\u201d{}\u201d][et_pb_fullwidth_header _builder_version=\u201d4.16\u2033 title_font=\u201d||||||||\u201d title_font_size=\u201d55\u2033 background_color=\u201d#29327a\u201d background_image=\u201dhttps:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2020\/12\/Jes.jpg\u201d background_position=\u201dcenter_left\u201d custom_padding=\u201d11.5w||11.5v vw || \u0916\u0930\u0947&quot; custom_padding_tablet=&quot;&quot; custom_padding_phone=&quot;|56px||&quot; custom_padding_last_edited=\u201d\u0911\u0928|\u0921\u0947\u0938\u094d\u0915\u091f\u0949\u092a\u201d title_font_size_tablet=\u201d45px\u201d title_font_size_phone=\u201d40px\u201d title_font_size_last_edited=\u201don|phone\u201d z_index_tablet=\u201d500\u2033 custom_css_main_element=\u201dTpg 3mportant=\u201dBackgimport:8 global_colors_info=\u201d{}\u201d] \u0935\u0948\u0926\u094d\u092f\u0915\u0940\u092f \u0921\u0947\u091f\u093e\u092c\u0947\u0938 [\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=\u201d1\u2033 use_custom_gutter=\u201don\u201d gutter_width=\u201d1\u2033 specialty=\u201don\u201d padding_left_1=\u201d5x=\u201d padding_left_2=\u201d35px\u201d padding_2_tablet=\u201d|||0px\u201d padding_2_phone=\u201d|||0px\u201d padding_2_last_edited=\u201d\u0911\u0928|\u0921\u0947\u0938\u094d\u0915\u091f\u0949\u092a\u201d module_class_1=\u201dsidebar-secondary-nav\u201d module_class=&quot;_b_6=\u201d_handprint=\u201dgirl-6\u201d background_image=\u201dhttps:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/blue-handprint-only.png\u201d parallax=\u201don\u201d parallax_method=\u201doff\u201d inner_width=\u201d100%\u201d inner_max_width=\u201d1001TP &quot; custom_padding=\u201d0|0px|54px|0px|false|false\u201d z_index_tablet=\u201d500\u2033 border_width_top=\u201d10px\u201d border_color_top=\u201d#8fd2ed\u201d use_custom_width=\u201don\u201d TP_width_unit=\u201d01th\u201d 0% off\u201d _Tp=1\u2026<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"\t\t\t\t[vc_row][vc_column][vc_custom_heading text=\"Medical Database\" font_container=\"tag:h1|text_align:center\" use_theme_fonts=\"yes\"][vc_column_text]<strong>What is the International Medical and Research Database?<\/strong>\r\n\r\nWe collect the medical records for children with Progeria from all over the world. Then we look at every aspect of medical care that has been given to the children. We perform statistical analyses, and look at what treatments have worked for maintaining quality of life and what treatments have not worked. Most doctors have only seen one child with Progeria, and they are not sure what to do when the child needs things like heart medications, anesthesia, and proper physical therapy. We have the ability to give advice to the doctors and their families based on this database program.\r\n\r\nThe Progeria Research Foundation is collaborating with Brown University Center for Gerontology and Health Care Research for this wonderful project. The Brown Center has many years of experience with creating and analyzing healthcare databases.\r\n\r\nWe also use the medical records to understand more about the basis of disease in Progeria, which serves as a springboard for new research in Progeria and in the diseases of aging such as heart disease. This may lead to clues for new treatments for the children and for all of us!\r\n\r\nThere has never been a centralized childhood Progeria database from which to draw health care information. This has led to unintentional clinical maltreatment of patients, misdiagnoses and delayed diagnoses, simply because caretakers do not know which medical strategies have been successful with other Progeria children and which have not. The goal of this project is to collect the health care records for children with Progeria and develop a centralized health database for use by health care professionals, medical researchers, and families of children with Progeria.\r\n\r\n<strong>Aims of the Database<\/strong>\r\n<ul>\r\n \t<li>To describe in detail what treatment strategies have been successful, and what treatments have failed for the medical issues faced by children with HGPS. This may help the families and their doctors understand how to best care for children with Progeria.<\/li>\r\n \t<li>To provide health care recommendations to families in non-medical language about the issues that are important to the quality of life for children with HGPS.<\/li>\r\n \t<li>The database is a resource for gaining new insights into the nature of HGPS and into the nature of other diseases such as atherosclerosis, which in turn will serve to stimulate the advancement of new research projects.<\/li>\r\n<\/ul>\r\n<strong>Institutional Review Board Approvals:<\/strong>\r\n\r\nThe PRF Medical and Research Database is Institutional Review Board (IRB) approved by the Rhode Island Hospital and the Brown University Committees on the Protection of Human Subjects. Rhode Island Hospital Federal Wide Assurance FWA00001230, Study CMTT# 0152-01, Brown University Federal Wide Assurance FWA 00004460, Study CMTT# 0211991243\r\n\r\n<strong>Publications Stemming From The Progeria Research Foundation Medical and Research Database<\/strong>\r\n\r\nThe Progeria Research Foundation Medical and Research Database has contributed to the following medical publications:\r\n\r\n<strong>Clinical Care Handbook<\/strong>\r\n\r\n<em>The Progeria Handbook; A Guide for Families and Health Care Providers of Children with Progeria.<\/em> Gordon, Leslie B., Executive Editor. Copyright 2019 by The Progeria Research Foundation. All rights reserved.\r\n\r\n<img src=\"https:\/\/www.progeriaresearch.org\/assets\/images\/iconPDF.gif\" width=\"34\" height=\"20\" \/> <a href=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/01\/Handbook-2018-PDF-One-File-v3-1.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Click here\u00a0<\/a>\u00a0to download the second edition of the Handbook in English.\r\n\r\nThe first edition of the handbook is available in Spanish and Portuguese versions. Translations of the second edition of the handbook in Spanish and Portuguese will be posted when available.\r\n\r\n<a href=\"https:\/\/www.progeriaresearch.org\/assets\/files\/pdf\/PRF%20Handbook%20Spanish.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><img src=\"https:\/\/www.progeriaresearch.org\/assets\/images\/iconPDF.gif\" width=\"34\" height=\"20\" \/><\/a>\u00a0<a href=\"https:\/\/www.progeriaresearch.org\/assets\/files\/pdf\/PRF%20Handbook%20Spanish.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Click here<\/a> to download the Handbook in Spanish.\r\n\r\n<a href=\"https:\/\/www.progeriaresearch.org\/assets\/files\/pdf\/PRF%20Handbook%20Spanish.pdf\"><img src=\"https:\/\/www.progeriaresearch.org\/assets\/images\/iconPDF.gif\" width=\"34\" height=\"20\" \/><\/a>\u00a0<a href=\"https:\/\/www.progeriaresearch.org\/assets\/files\/pdf\/Handbook---Portuguese.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Click here<\/a> to download the Handbook in Portuguese.\r\n\r\n<strong>Journal Articles<\/strong>\r\n\r\n<strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28756152\" target=\"_blank\" rel=\"noopener noreferrer\">Ophthalmologic\u00a0Features\u00a0of\u00a0Progeria.\r\n<\/a><\/strong>Mantagos IS, Kleinman ME, Kieran MW, Gordon LB.\r\nAm J Ophthalmol. 2017 Jul 27. pii: S0002-9394(17)30317-3. doi: 10.1016\/j.ajo.2017.07.020. [Epub ahead of print]\r\n\r\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27920058\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>A\u00a0novel\u00a0somatic\u00a0mutation\u00a0achieves\u00a0partial rescue in a child with Hutchinson-Gilford progeria syndrome.<\/strong>\r\n<\/a>Bar DZ, Arlt MF, Brazier JF, Norris WE, Campbell SE, Chines P, Larrieu D, Jackson SP, Collins FS, Glover TW, Gordon LB.\r\nJ Med Genet. 2017 Mar;54(3):212-216. doi: 10.1136\/jmedgenet-2016-104295. Epub 2016 Dec 5.\r\n\r\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27799555\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Cardiac\u00a0electrical\u00a0defects\u00a0in\u00a0progeroid\u00a0mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations.<\/strong>\r\n<\/a>Rivera-Torres J, Calvo CJ, Llach A, Guzm\u00e1n-Mart\u00ednez G, Caballero R, Gonz\u00e1lez-G\u00f3mez C, Jim\u00e9nez-Borreguero LJ, Guadix JA, Osorio FG, L\u00f3pez-Ot\u00edn C, Herraiz-Mart\u00ednez A, Cabello N, Vallmitjana A, Ben\u00edtez R, Gordon LB, Jalife J, P\u00e9rez-Pomares JM, Tamargo J, Delp\u00f3n E, Hove-Madsen L, Filgueiras-Rama D, Andr\u00e9s V.\r\nProc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7250-E7259. Epub 2016 Oct 31.\r\n\r\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27400896\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Clinical Trial\u00a0of the\u00a0Protein Farnesylation\u00a0Inhibitors\u00a0Lonafarnib, Pravastatin, and Zoledronic Acid in Children With Hutchinson-Gilford Progeria Syndrome.<\/strong>\r\n<\/a>Gordon LB, Kleinman ME, Massaro J, D'Agostino RB Sr, Shappell H, Gerhard-Herman M, Smoot LB, Gordon CM, Cleveland RH, Nazarian A, Snyder BD, Ullrich NJ, Silvera VM, Liang MG, Quinn N, Miller DT, Huh SY, Dowton AA, Littlefield K, Greer MM, Kieran MW.\r\nCirculation. 2016 Jul 12;134(2):114-25. doi: 10.1161\/CIRCULATIONAHA.116.022188.\r\n\r\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26564085\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Hutchinson-Gilford progeria syndrome.<\/strong>\r\n<\/a>Ullrich NJ, Gordon LB.\r\nHandb Clin Neurol. 2015;132:249-64.\r\n\r\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24795390\"><strong>Impact\u00a0of\u00a0farnesylation\u00a0inhibitors\u00a0on\u00a0survival\u00a0in hutchinson-gilford progeria syndrome.<\/strong>\r\n<\/a>Gordon LB, Massaro J, D'Agostino RB Sr, Campbell SE, Brazier J, Brown WT, Kleinman ME, Kieran MW; Progeria Clinical Trials Collaborative.\r\nCirculation. 2014 Jul 1;130(1):27-34. doi: 10.1161\/CIRCULATIONAHA.113.008285. Epub 2014 May 2.\r\n\r\n<strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24456199\">Initial\u00a0Cutaneous\u00a0Manifestations of Hutchinson-Gilford Progeria Syndrome.<\/a>\u00a0<\/strong>Rork JF, Huang JT, Gordon LB, Kleinman M, Kieran MW, Liang MG. Pediatr Dermatol. 2014 Jan 24: 1-7. doi: 10.1111\/pde.12284.\r\n<p class=\"desc\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23897869\"><b>Neurologic<\/b>\u00a0<b>features<\/b>\u00a0of\u00a0<b>Hutchinson-Gilford<\/b>\u00a0progeria syndrome after lonafarnib treatment.\r\n<\/a>Ullrich NJ, Kieran MW, Miller DT, Gordon LB, Cho YJ, Silvera VM, Giobbie-Hurder A, Neuberg D, Kleinman ME. <i>Neurology<\/i>. 2013 Jul 30;81(5):427-30. doi: 10.1212\/WNL.0b013e31829d85c0. Epub 2013 Jun 28.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23179651\"><b>Imaging<\/b>\u00a0<b>characteristics<\/b>\u00a0of\u00a0<b>cerebrovascular<\/b>\u00a0<b>arteriopathy<\/b>\u00a0and\u00a0<b>stroke<\/b>\u00a0in Hutchinson-Gilford progeria syndrome.<\/a> Silvera VM, Gordon LB, Orbach DB, Campbell SE, Machan JT, Ullrich NJ.\r\n<i>AJNR Am J Neuroradiol<\/i>. 2013 May;34(5):1091-7. doi: 10.3174\/ajnr.A3341. Epub 2012 Nov 22.<\/p>\r\n<p class=\"desc\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22460337\"><b>Craniofacial abnormalities<\/b>\u00a0in\u00a0<b>Hutchinson<\/b>-Gilford progeria syndrome.\r\n<\/a>Ullrich NJ, Silvera VM, Campbell SE, Gordon LB. <i>AJNR Am J Neuroradiol<\/i>. 2012 Sep;33(8):1512-8. doi: 10.3174\/ajnr.A3088. Epub 2012 Mar 29.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23012407\"><b>Clinical trial<\/b>\u00a0of a\u00a0<b>farnesyltransferase<\/b>\u00a0<b>inhibitor<\/b>\u00a0in\u00a0<b>children<\/b>\u00a0with\u00a0<b>Hutchinson<\/b>-Gilford progeria syndrome.<\/a> Gordon LB, Kleinman ME, Miller DT, Neuberg DS, Giobbie-Hurder A, Gerhard-Herman M, Smoot LB, Gordon CM, Cleveland R, Snyder BD, Fligor B, Bishop WR, Statkevich P, Regen A, Sonis A, Riley S, Ploski C, Correia A, Quinn N, Ullrich NJ, Nazarian A, Liang MG, Huh SY, Schwartzman A, Kieran MW. <i>Proc Natl Acad Sci U S A<\/i>. 2012 Oct 9;109(41):16666-71. doi: 10.1073\/pnas.1202529109. Epub 2012 Sep 24<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22083160\"><b>Mechanisms<\/b>\u00a0of\u00a0<b>premature<\/b>\u00a0<b>vascular<\/b>\u00a0<b>aging<\/b>\u00a0in\u00a0<b>children<\/b>\u00a0with\u00a0<b>Hutchinson<\/b>-Gilford progeria syndrome.<\/a> Gerhard-Herman M, Smoot LB, Wake N, Kieran MW, Kleinman ME, Miller DT, Schwartzman A, Giobbie-Hurder A, Neuberg D, Gordon LB. <i>Hypertension<\/i>. 2012 Jan;59(1):92-7. doi: 10.1161\/HYPERTENSIONAHA.111.180919. Epub 2011 Nov 14.<\/p>\r\n<p class=\"desc\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22752073\"><strong>A\u00a0prospective study\u00a0of\u00a0radiographic\u00a0manifestations\u00a0in Hutchinson-Gilford progeria syndrome.<\/strong>\r\n<\/a>Cleveland RH, Gordon LB, Kleinman ME, Miller DT, Gordon CM, Snyder BD, Nazarian A, Giobbie-Hurder A, Neuberg D, Kieran MW. <i>Pediatr Radiol<\/i>. 2012 Sep;42(9):1089-98. doi: 10.1007\/s00247-012-2423-1. Epub 2012 Jul 1.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21980471\"><b>Low<\/b>\u00a0and\u00a0<b>high<\/b>\u00a0<b>expressing<\/b>\u00a0<b>alleles<\/b>\u00a0of the LMNA gene: implications for laminopathy disease development.<\/a> Rodr\u00edguez S, Eriksson M. <i>PLoS One<\/i>. 2011;6(9):e25472. doi: 10.1371\/journal.pone.0025472. Epub 2011 Sep 29.\r\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21445982\"><b>\r\nHutchinson-Gilford<\/b>\u00a0<b>progeria<\/b>\u00a0is a\u00a0<b>skeletal<\/b>\u00a0dysplasia.<\/a> Gordon CM, Gordon LB, Snyder BD, Nazarian A, Quinn N, Huh S, Giobbie-Hurder A, Neuberg D, Cleveland R, Kleinman M, Miller DT, Kieran MW. <i>J Bone Miner Res<\/i>. 2011 Jul;26(7):1670-9. doi: 10.1002\/jbmr.392.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20798379\"><b>Cardiovascular pathology<\/b>\u00a0in\u00a0<b>Hutchinson<\/b>-Gilford progeria: correlation with the vascular<b>pathology<\/b>\u00a0of aging.<\/a> Olive M, Harten I, Mitchell R, Beers JK, Djabali K, Cao K, Erdos MR, Blair C, Funke B, Smoot L, Gerhard-Herman M, Machan JT, Kutys R, Virmani R, Collins FS, Wight TN, Nabel EG, Gordon LB. <i>Arterioscler Thromb Vasc Biol<\/i>. 2010 Nov;30(11):2301-9. doi: 10.1161\/ATVBAHA.110.209460. Epub 2010 Aug 26.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19236595\"><b>Hutchinson-Gilford<\/b>\u00a0<b>progeria<\/b>\u00a0<b>syndrome<\/b>:\u00a0<b>oral<\/b>\u00a0and craniofacial phenotypes.<\/a> Domingo DL, Trujillo MI, Council SE, Merideth MA, Gordon LB, Wu T, Introne WJ, Gahl WA, Hart TC. <i>Oral<\/i><i>\u00a0<\/i><i>Dis<\/i>. 2009 Apr;15(3):187-95. doi: 10.1111\/j.1601-0825.2009.01521.x. Epub 2009 Feb 19.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18334552\"><b>Targeted<\/b>\u00a0<b>transgenic<\/b>\u00a0<b>expression<\/b>\u00a0of the\u00a0<b>mutation<\/b>\u00a0<b>causing<\/b>\u00a0Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease.<\/a> Sagelius H, Rosengardten Y, Hanif M, Erdos MR, Rozell B, Collins FS, Eriksson M. <i>J Cell Sci<\/i>. 2008 Apr 1;121(Pt 7):969-78. doi: 10.1242\/jcs.022913. Epub 2008 Mar 11.<\/p>\r\n<p class=\"desc\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18708427\"><b>Reversible<\/b>\u00a0<b>phenotype<\/b>\u00a0in a\u00a0<b>mouse<\/b>\u00a0model of Hutchinson-Gilford progeria syndrome.\r\n<\/a>Sagelius H, Rosengardten Y, Schmidt E, Sonnabend C, Rozell B, Eriksson M. <i>J Med Genet<\/i>. 2008 Dec;45(12):794-801. doi: 10.1136\/jmg.2008.060772. Epub 2008 Aug 15.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18256394\"><b>Phenotype<\/b>\u00a0and\u00a0<b>course<\/b>\u00a0of\u00a0<b>Hutchinson<\/b>-Gilford progeria syndrome.<\/a> Merideth MA, Gordon LB, Clauss S, Sachdev V, Smith AC, Perry MB, Brewer CC, Zalewski C, Kim HJ, Solomon B, Brooks BP, Gerber LH, Turner ML, Domingo DL, Hart TC, Graf J, Reynolds JC, Gropman A, Yanovski JA, Gerhard-Herman M, Collins FS, Nabel EG, Cannon RO 3rd, Gahl WA, Introne WJ. <i>N Engl J Med<\/i>. 2008 Feb 7;358(6):592-604. doi: 10.1056\/NEJMoa0706898.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17908771\"><b>New<\/b>\u00a0<b>approaches<\/b>\u00a0to\u00a0<b>progeria<\/b>.<\/a> Kieran MW, Gordon L, Kleinman M. Pediatrics. 2007 Oct;120(4):834-41. Review. Erratum in: <i>Pediatrics<\/i>. 2007 Dec;120(6):1405.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17908770\"><b>Disease progression<\/b>\u00a0in\u00a0<b>Hutchinson-Gilford<\/b>\u00a0progeria syndrome: impact on growth and development.<\/a> Gordon LB, McCarten KM, Giobbie-Hurder A, Machan JT, Campbell SE, Berns SD, Kieran MW. <i>Pediatrics<\/i>. 2007 Oct;120(4):824-33.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15756215\"><b>Reduced<\/b>\u00a0<b>adiponectin<\/b>\u00a0and\u00a0<b>HDL cholesterol<\/b>\u00a0without\u00a0<b>elevated<\/b>\u00a0<b>C-reactive protein<\/b>: clues to the biology of premature atherosclerosis in Hutchinson-Gilford Progeria Syndrome.<\/a> Gordon LB, Harten IA, Patti ME, Lichtenstein AH. <i>J Pediatr<\/i>. 2005 Mar;146(3):336-41.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16129833\"><b>Inhibiting<\/b>\u00a0<b>farnesylation<\/b>\u00a0of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford\u00a0<b>progeria<\/b>\u00a0syndrome.<\/a> Capell BC, Erdos MR, Madigan JP, Fiordalisi JJ, Varga R, Conneely KN, Gordon LB, Der CJ, Cox AD, Collins FS. <i>Proc Natl Acad Sci U S A<\/i>. 2005 Sep 6;102(36):12879-84. Epub 2005 Aug 29<\/p>\r\n<p class=\"details\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15184648\"><b>Accumulation<\/b>\u00a0of\u00a0<b>mutant<\/b>\u00a0<b>lamin A<\/b>\u00a0<b>causes<\/b>\u00a0progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome.<\/a> Goldman RD, Shumaker DK, Erdos MR, Eriksson M, Goldman AE, Gordon LB, Gruenbaum Y, Khuon S, Mendez M, Varga R, Collins FS. <i>Proc Natl Acad Sci U S A<\/i>. 2004 Jun 15;101(24):8963-8. Epub 2004 Jun 7.<\/p>\r\n<strong>Books and Documents<\/strong>\r\n\r\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20301300\" target=\"_blank\" rel=\"noopener noreferrer\">Hutchinson-Gilford Progeria Syndrome.<\/a>\u00a0 Gordon LB, Brown WT, Collins FS. In: Pagon RA, Bird TD, Dolan CR, Stephens K, editors. GeneReviews [Internet]. Seattle (WA): University of Washington, Seattle; 1993-.\r\n2003 Dec 12 [updated 2011 Jan 06].\r\n\r\nThe Premature Aging Syndrome Hutchinson-Gilford Progeria: Insights Into Normal Aging. Gordon, Leslie. Chapter in the 7th edition of <em>Brocklehurst\u2019s Textbook of Geriatric Medicine and Gerontology<\/em>. Copyright: 2010.\r\n\r\n<em>LMNA<\/em> and the Hutchinson-Gilford Progeria Syndrome and Associated Laminopathies. Gordon LB, Brown WT, Rothman FG. \u00a0In C. J. Epstein, R. P. Erickson, A. Wynshaw-Boris (Eds.)<em> Inborn Errors of Development: The molecular basis of clinical disorders of morphogenesis<\/em> (2<sup>nd<\/sup> ed.). New York, NY: Oxford University Press. 2008 139: 1219-1229.[\/vc_column_text][vc_column_text]Sam passed away on January 10, 2014, leaving a legacy of inspiration that now drives PRF and its supporters to continue the quest for a cure, with more determination than ever. <a href=\"https:\/\/www.progeriaresearch.org\/sam-berns-102396-0110141.html\">Click here<\/a> to learn more about this remarkable young man.[\/vc_column_text][vc_column_text]Together with caring, dedicated board members and other generous volunteers, The Progeria Research Foundation was created to raise awareness, educate and help the families, their doctors, researchers and the general public about Hutchinson-Gilford Progeria Syndrome. In addition, PRF funds medical research and runs research-related programs specifically aimed at finding the cause*, treatments, and cure for this syndrome.[\/vc_column_text][vc_column_text]Since its inception, PRF has benefited from the leadership of Attorney Audrey Gordon, Sam's aunt, who serves as the organization's President and Executive Director.[\/vc_column_text][vc_column_text]<strong>Did you know?<\/strong>\r\n\r\nWith the exception of our staff, everyone involved with PRF is a volunteer! Our Board of Directors, Clerk, Treasurer, committee members, translators, fund-raisers, etc. all devote their time, energy and talents to furthering our mission without pay. As a result, our administrative costs are very low. This leaves more money to devote to medical research and raising public awareness, which ultimately lead to finding a cure for Progeria.[\/vc_column_text][vc_column_text css=\".vc_custom_1508790933490{background-color: #ffffff !important;}\"]\r\n<p class=\"\">Leslie B. Gordon, MD, PhD, is PRF's Medical Director. She is also the Principal Investigator of PRF's research-related programs: The PRF International Registry, Cell & Tissue Bank, Medical & Research Database, and Diagnostics Testing Program, and co-author on the historic Progeria gene finding and treatment discovery*.<\/p>\r\n[\/vc_column_text][vc_column_text css=\".vc_custom_1488054553154{background-color: #ffffff !important;}\"]\r\n<p class=\"\">* Thanks to PRF's efforts, in April 2003 PRF and the National Institutes of Health announced that <a href=\"https:\/\/www.progeriaresearch.org\/identification_of_gene_gives_hope_to_children_with_progeria.html\">the cause of Progeria, a mutation in the LMNA gene, was found<\/a>, and in September 2012, <a href=\"https:\/\/www.progeriaresearch.org\/first-ever-progeria-treatment.html\">the first-ever treatment was discovered.<\/a><\/p>\r\n[\/vc_column_text][vc_column_text css=\".vc_custom_1488054565202{background-color: #ffffff !important;}\"]There is much work to be done and little resources with which to do so. We cannot do it alone. With your support, the cure will be discovered for these wonderful children.[\/vc_column_text][vc_column_text css=\".vc_custom_1488054579010{background-color: #ffffff !important;}\"]Together, we <em>WILL<\/em> find the cure.[\/vc_column_text][\/vc_column][\/vc_row]\t\t","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-788","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Database | The Progeria Research Foundation<\/title>\n<meta name=\"description\" content=\"As part of our continued efforts in finding the cure, PRF collects the medical records for children with Progeria from all over the world.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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