{"id":2054,"date":"2011-05-16T12:41:18","date_gmt":"2011-05-16T12:41:18","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?p=2054"},"modified":"2020-12-10T17:52:21","modified_gmt":"2020-12-10T22:52:21","slug":"prf-funded-study-identifies-rapamycin-as-possible-treatment-for-progeria","status":"publish","type":"post","link":"https:\/\/www.progeriaresearch.org\/mr\/2011\/05\/16\/prf-funded-study-identifies-rapamycin-as-possible-treatment-for-progeria\/","title":{"rendered":"PRF-\u0928\u093f\u0927\u0940\u091a\u093e \u0905\u092d\u094d\u092f\u093e\u0938 \u0930\u0945\u092a\u093e\u092e\u093e\u092f\u0938\u093f\u0928\u0932\u093e \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e\u0938\u093e\u0920\u0940 \u0938\u0902\u092d\u093e\u0935\u094d\u092f \u0909\u092a\u091a\u093e\u0930 \u092e\u094d\u0939\u0923\u0942\u0928 \u0913\u0933\u0916\u0924\u094b"},"content":{"rendered":"

[et_pb_section fb_built=\u201d1\u2033 _builder_version=\u201d3.22\u2033][et_pb_row _builder_version=\u201d3.25\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201drepeat\u201d][et_pb_column type=\u201d4_4\u2033 _builder_version=\u201d3.25\u2033 custom_padding=\u201d||\u201d custom_padding__hover=\u201d||\u201d][et_pb_text _builder_version=\u201d4.6.5\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201drepeat\u201d hover_enabled=\u201d0\u2033 sticky_enabled=\u201d0\u2033]<\/p>\n

\u092c\u094b\u0938\u094d\u091f\u0928\u092e\u0927\u0940\u0932 \u0928\u0945\u0936\u0928\u0932 \u0907\u0928\u094d\u0938\u094d\u091f\u093f\u091f\u094d\u092f\u0942\u091f \u0911\u092b \u0939\u0947\u0932\u094d\u0925 \u0906\u0923\u093f \u092e\u0945\u0938\u0945\u091a\u094d\u092f\u0941\u0938\u0947\u091f\u094d\u0938 \u091c\u0928\u0930\u0932 \u0939\u0949\u0938\u094d\u092a\u093f\u091f\u0932\u092e\u0927\u0940\u0932 \u0938\u0902\u0936\u094b\u0927\u0915\u093e\u0902\u0928\u0940 \u0906\u091c \u090f\u0915 \u0928\u0935\u0940\u0928 \u0905\u092d\u094d\u092f\u093e\u0938 \u092a\u094d\u0930\u0915\u093e\u0936\u093f\u0924 \u0915\u0947\u0932\u093e. \u0935\u093f\u091c\u094d\u091e\u093e\u0928, \u092d\u093e\u0937\u093e\u0902\u0924\u0930\u093f\u0924 \u0914\u0937\u0927<\/em> \u091c\u094d\u092f\u093e\u092e\u0941\u0933\u0947 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0905\u0938\u0932\u0947\u0932\u094d\u092f\u093e \u092e\u0941\u0932\u093e\u0902\u0938\u093e\u0920\u0940 \u0928\u0935\u0940\u0928 \u0914\u0937\u0927 \u0909\u092a\u091a\u093e\u0930 \u0939\u094b\u090a \u0936\u0915\u0924\u093e\u0924.*<\/p>\n

\n

\u0930\u0947\u092a\u093e\u092e\u093e\u092f\u0938\u093f\u0928<\/em> \u090f\u0915 FDA \u092e\u0902\u091c\u0942\u0930 \u0914\u0937\u0927 \u0906\u0939\u0947 \u091c\u0947 \u092f\u093e\u092a\u0942\u0930\u094d\u0935\u0940 \u0928\u0949\u0928-\u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u092e\u093e\u090a\u0938 \u092e\u0949\u0921\u0947\u0932\u094d\u0938\u091a\u0947 \u0906\u092f\u0941\u0937\u094d\u092f \u0935\u093e\u0922\u0935\u0923\u094d\u092f\u093e\u0938 \u0926\u0930\u094d\u0936\u0935\u093f\u0932\u0947 \u0917\u0947\u0932\u0947 \u0906\u0939\u0947. \u092f\u093e \u0928\u0935\u0940\u0928 \u0905\u092d\u094d\u092f\u093e\u0938\u093e\u0924\u0942\u0928 \u0905\u0938\u0947 \u0926\u093f\u0938\u0942\u0928 \u0906\u0932\u0947 \u0906\u0939\u0947 \u0915\u0940 \u0930\u0945\u092a\u093e\u092e\u093e\u092f\u0938\u0940\u0928 \u0930\u094b\u0917\u093e\u0938 \u0915\u093e\u0930\u0923\u0940\u092d\u0942\u0924 \u0905\u0938\u0932\u0947\u0932\u094d\u092f\u093e \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u0928\u091a\u0947 \u092a\u094d\u0930\u092e\u093e\u0923 50% \u0928\u0947 \u0915\u092e\u0940 \u0915\u0930\u0924\u0947, \u0905\u0938\u093e\u092e\u093e\u0928\u094d\u092f \u0906\u0923\u094d\u0935\u093f\u0915 \u0906\u0915\u093e\u0930 \u0938\u0941\u0927\u093e\u0930\u0924\u0947 \u0906\u0923\u093f \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u092a\u0947\u0936\u0940\u0902\u091a\u0947 \u0906\u092f\u0941\u0937\u094d\u092f \u0935\u093e\u0922\u0935\u0924\u0947. \u0939\u093e \u0905\u092d\u094d\u092f\u093e\u0938 \u092a\u094d\u0930\u0925\u092e \u092a\u0941\u0930\u093e\u0935\u093e \u092a\u094d\u0930\u0926\u093e\u0928 \u0915\u0930\u0924\u094b \u0915\u0940 \u0930\u0945\u092a\u093e\u092e\u093e\u0907\u0938\u093f\u0928 \u0915\u092e\u0940 \u0939\u094b\u090a \u0936\u0915\u0924\u0947 \"\"\u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0905\u0938\u0932\u0947\u0932\u094d\u092f\u093e \u092e\u0941\u0932\u093e\u0902\u092e\u0927\u094d\u092f\u0947 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u0928\u091a\u0947 \u0939\u093e\u0928\u093f\u0915\u093e\u0930\u0915 \u092a\u094d\u0930\u092d\u093e\u0935.<\/p>\n

\u092f\u093e\u0935\u0930 \u092a\u094d\u0930\u091a\u0902\u0921 \u092e\u0940\u0921\u093f\u092f\u093e \u0915\u0935\u094d\u0939\u0930\u0947\u091c \u0906\u0939\u0947! \u092e\u0940\u0921\u093f\u092f\u093e \u0938\u094d\u091f\u094b\u0930\u0940\u091c\u091a\u094d\u092f\u093e \u0932\u093f\u0902\u0915\u094d\u0938\u0938\u093e\u0920\u0940 \u0916\u093e\u0932\u0940 \u0915\u094d\u0932\u093f\u0915 \u0915\u0930\u093e:<\/p>\n

\u0935\u0949\u0932 \u0938\u094d\u091f\u094d\u0930\u0940\u091f \u091c\u0930\u094d\u0928\u0932 \u0939\u0947\u0932\u094d\u0925 \u092c\u094d\u0932\u0949\u0917<\/a><\/strong><\/p>\n

\u092f\u0942\u090f\u0938 \u092c\u093e\u0924\u092e\u094d\u092f\u093e \u0906\u0923\u093f \u091c\u093e\u0917\u0924\u093f\u0915 \u0905\u0939\u0935\u093e\u0932<\/a><\/strong><\/p>\n

\u0935\u093f\u091c\u094d\u091e\u093e\u0928 \u092e\u093e\u0938\u093f\u0915<\/a><\/strong><\/p>\n

\u092c\u094b\u0938\u094d\u091f\u0928 \u0917\u094d\u0932\u094b\u092c<\/a><\/strong><\/p>\n

CNN<\/strong> (\u0926\u0941\u0935\u093e \u092f\u093e\u092a\u0941\u0922\u0947 \u0938\u0915\u094d\u0930\u093f\u092f \u0928\u093e\u0939\u0940)
<\/strong><\/p>\n

\u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0930\u093f\u0938\u0930\u094d\u091a \u092b\u093e\u0909\u0902\u0921\u0947\u0936\u0928\u0932\u093e \u092f\u093e \u092a\u094d\u0930\u0915\u0932\u094d\u092a\u093e\u0938\u093e\u0920\u0940 \u0938\u0947\u0932\u094d\u0938 \u092a\u094d\u0930\u0926\u093e\u0928 \u0915\u0930\u0923\u094d\u092f\u093e\u0924 \u0906\u0928\u0902\u0926 \u091d\u093e\u0932\u093e PRF \u0938\u0947\u0932 \u0906\u0923\u093f \u091f\u093f\u0936\u094d\u092f\u0942 \u092c\u0901\u0915<\/a>, \u0906\u0923\u093f \u0906\u092e\u091a\u094d\u092f\u093e\u0926\u094d\u0935\u093e\u0930\u0947 \u0938\u0902\u0936\u094b\u0927\u0928\u093e\u0938\u093e\u0920\u0940 \u0928\u093f\u0927\u0940 \u092e\u0926\u0924 \u0915\u0930\u093e \u0905\u0928\u0941\u0926\u093e\u0928 \u0915\u093e\u0930\u094d\u092f\u0915\u094d\u0930\u092e<\/a>.<\/p>\n

\u0939\u093e \u0930\u094b\u092e\u093e\u0902\u091a\u0915 \u0928\u0935\u0940\u0928 \u0905\u092d\u094d\u092f\u093e\u0938 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u0938\u0902\u0936\u094b\u0927\u0928\u093e\u091a\u0940 \u0909\u0932\u094d\u0932\u0947\u0916\u0928\u0940\u092f \u0917\u0924\u0940 \u0926\u0930\u094d\u0936\u0935\u093f\u0924\u094b, \u0924\u0938\u0947\u091a \u0935\u0943\u0926\u094d\u0927\u0924\u094d\u0935\u093e\u091a\u094d\u092f\u093e \u092a\u094d\u0930\u0915\u094d\u0930\u093f\u092f\u0947\u092c\u0926\u094d\u0926\u0932 \u0905\u0927\u093f\u0915 \u0905\u0902\u0924\u0930\u094d\u0926\u0943\u0937\u094d\u091f\u0940 \u092a\u094d\u0930\u0926\u093e\u0928 \u0915\u0930\u0924\u094b \u091c\u0940 \u0906\u092a\u0932\u094d\u092f\u093e \u0938\u0930\u094d\u0935\u093e\u0902\u0928\u093e \u092a\u094d\u0930\u092d\u093e\u0935\u093f\u0924 \u0915\u0930\u0924\u0947.<\/p>\n

*"Rapamycin \u0938\u0947\u0932\u094d\u092f\u0941\u0932\u0930 \u092b\u0940\u0928\u094b\u091f\u093e\u0907\u092a\u094d\u0938 \u0909\u0932\u091f \u0915\u0930\u0924\u0947 \u0906\u0923\u093f \u0939\u091a\u093f\u0928\u094d\u0938\u0928-\u0917\u093f\u0932\u092b\u094b\u0930\u094d\u0921 \u092a\u094d\u0930\u094b\u091c\u0947\u0930\u093f\u092f\u093e \u092a\u0947\u0936\u0940\u0902\u092e\u0927\u094d\u092f\u0947 \u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0940 \u092a\u094d\u0930\u094b\u091f\u0940\u0928 \u0915\u094d\u0932\u093f\u0905\u0930\u0928\u094d\u0938 \u0935\u093e\u0922\u0935\u0924\u0947"
\u0915\u093e\u0928 \u0915\u093e\u0913, \u091c\u0949\u0928 \u091c\u0947. \u0917\u094d\u0930\u0945\u091d\u093f\u0913\u091f\u094d\u091f\u094b, \u0938\u0947\u0938\u093f\u0932\u093f\u092f\u093e \u0921\u0940. \u092c\u094d\u0932\u0947\u0905\u0930, \u091c\u094b\u0938\u0947\u092b \u0906\u0930. \u092e\u093e\u091d\u0941\u0932\u094d\u0932\u0940, \u092e\u093e\u092f\u0915\u0947\u0932 \u0906\u0930. \u090f\u0930\u094d\u0921\u094b\u0938, \u0926\u093f\u092e\u093f\u0924\u094d\u0930\u0940 \u0915\u094d\u0930\u0947\u0928, \u092b\u094d\u0930\u093e\u0928\u094d\u0938\u093f\u0938 \u090f\u0938. \u0915\u0949\u0932\u093f\u0928\u094d\u0938
29 \u091c\u0942\u0928 2011 \u0916\u0902\u0921 3 \u0905\u0902\u0915 89
Epub \u092a\u094d\u0930\u093f\u0902\u091f\u091a\u094d\u092f\u093e \u092a\u0941\u0922\u0947<\/p>\n<\/div>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”3.22″][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.6.5″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” hover_enabled=”0″ sticky_enabled=”0″] Researchers at the National Institutes of Health and Massachusetts General Hospital in Boston, MA published a new study today in Science, Translational Medicine that may lead to a new drug treatment for children with Progeria.* Rapamycin is an […]<\/p>","protected":false},"author":1,"featured_media":11636,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"

[vc_custom_heading text=\"PRF-funded study Identifies Rapamycin as Possible Treatment for Progeria\" font_container=\"tag:h1|text_align:left\" use_theme_fonts=\"yes\"]<\/p>

Researchers at the National Institutes of Health and Massachusetts General Hospital in Boston, MA published a new study today in Science, Translational Medicine<\/em> that may lead to a new drug treatment for children with Progeria.*<\/p>

Rapamycin<\/em> is an FDA approved drug that has previously been shown to extend the lives of non-progeria mouse models. This new study demonstrates that rapamycin decreases the amount of the disease-causing protein progerin by 50%, improves the abnormal nuclear shape, and extends the lifespan of progeria cells. This study provides the first evidence that rapamycin may be able to decrease \"\"progerin's damaging effects in children with progeria.<\/p>

There is tremendous media coverage on this! Click below for links to media stories:<\/p>

Wall Street Journal Health Blog<\/a><\/strong><\/p>

US News and World Report<\/a><\/strong><\/p>

Science Magazine<\/a><\/strong><\/p>

Boston Globe<\/a><\/strong><\/p>

CNN<\/a>
<\/strong><\/p>

The Progeria Research Foundation was delighted to provide cells for this project from the PRF Cell & Tissue Bank<\/a>, and help fund the research through our grants program<\/a>.<\/p>

This exciting new study demonstrates the remarkable pace of progeria research, while providing further insight into the aging process that affects us all.<\/p>

*\"Rapamycin Reverses Cellular Phenotypes and Enhances Mutant Protein Clearance in Hutchinson-Gilford Progeria Cells\"
Kan Cao, John J. Graziotto, Cecilia D. Blair, Joseph R. Mazzulli, Michael R. Erdos, Dimitri Krainc, Francis S. Collins
29 June 2011 Vol 3 Issue 89
Epub ahead of print<\/p><\/div>","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-2054","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"yoast_head":"\nPRF-funded study Identifies Rapamycin as Possible Treatment for Progeria - The Progeria Research Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.progeriaresearch.org\/mr\/2011\/05\/16\/prf-funded-study-identifies-rapamycin-as-possible-treatment-for-progeria\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PRF-funded study Identifies Rapamycin as Possible Treatment for Progeria - The Progeria Research Foundation\" \/>\n<meta property=\"og:description\" content=\"[et_pb_section fb_built=”1″ _builder_version=”3.22″][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.6.5″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” hover_enabled=”0″ sticky_enabled=”0″] Researchers at the National Institutes of Health and Massachusetts General Hospital in Boston, MA published a new study today in Science, Translational Medicine that may lead to a new drug treatment for children with Progeria.* Rapamycin is an […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.progeriaresearch.org\/mr\/2011\/05\/16\/prf-funded-study-identifies-rapamycin-as-possible-treatment-for-progeria\/\" \/>\n<meta property=\"og:site_name\" content=\"The Progeria Research Foundation\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ProgeriaResearch\/\" \/>\n<meta property=\"article:published_time\" content=\"2011-05-16T12:41:18+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-12-10T22:52:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2006\/05\/cells-e1607545663671.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"733\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"gravoc\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@Progeria\" \/>\n<meta name=\"twitter:site\" content=\"@Progeria\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"gravoc\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 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Researchers at the National Institutes of Health and Massachusetts General Hospital in Boston, MA published a new study today in Science, Translational Medicine that may lead to a new drug treatment for children with Progeria.* Rapamycin is an […]","og_url":"https:\/\/www.progeriaresearch.org\/mr\/2011\/05\/16\/prf-funded-study-identifies-rapamycin-as-possible-treatment-for-progeria\/","og_site_name":"The Progeria Research Foundation","article_publisher":"https:\/\/www.facebook.com\/ProgeriaResearch\/","article_published_time":"2011-05-16T12:41:18+00:00","article_modified_time":"2020-12-10T22:52:21+00:00","og_image":[{"width":500,"height":733,"url":"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2006\/05\/cells-e1607545663671.jpg","type":"image\/jpeg"}],"author":"gravoc","twitter_card":"summary_large_image","twitter_creator":"@Progeria","twitter_site":"@Progeria","twitter_misc":{"Written by":"gravoc","Est. reading time":"1 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