{"id":2128,"date":"2005-05-16T20:41:26","date_gmt":"2005-05-16T20:41:26","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?p=2128"},"modified":"2020-12-09T11:08:36","modified_gmt":"2020-12-09T16:08:36","slug":"exciting-news-on-potential-drug-treatments","status":"publish","type":"post","link":"https:\/\/www.progeriaresearch.org\/nl\/2005\/05\/16\/exciting-news-on-potential-drug-treatments\/","title":{"rendered":"Spannend nieuws over mogelijke medicamenteuze behandelingen"},"content":{"rendered":"

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\n

Augustus 2005 \u2013 februari 2006: Onderzoekers hebben studies gepubliceerd die een mogelijke medicamenteuze behandeling voor kinderen met Progeria ondersteunen. Farnesyltransferaseremmers (FTI's), oorspronkelijk ontwikkeld voor kanker, zijn in staat de dramatische afwijkingen in de kernstructuur die kenmerkend zijn voor cellen van kinderen met Progeria, om te keren.<\/p>\n

Hier zijn enkele antwoorden op veelgestelde vragen over FTI's en deze recente bevindingen<\/a><\/strong><\/p>\n

Uit het lab van Susan Michaelis aan de Johns Hopkins University School of Medicine en de University of Seattle. Eerste auteur: Monica Mallampalli.<\/a> PRF financierde deze studie.<\/em> Klik hier<\/a> voor het artikel \"<\/p>\n

Uit het laboratorium van Dr. Thomas Glover aan de Universiteit van Michigan.<\/a> Eerste auteur: Michael W. Glynn. PRF financierde deze studie.<\/em> Klik hier<\/a> voor het artikel \"<\/p>\n

Uit het laboratorium van Dr. Francis Collins van het National Human Genome Research Institute: Eerste auteur: Brian Capell.<\/a> Extra auteur: PRF's medisch directeur Dr. Leslie Gordon<\/em><\/p>\n

Capell BC, Erdos MR, Madigan JP, Fiordalisi JJ, Varga R, Conneely KN, et al. Door de farnesylering van progerine te remmen, wordt de karakteristieke nucleaire blaarvorming van het Hutchinson-Gilford progeriasyndroom voorkomen.<\/em> Proc Natl Acad Sci USA 2005;102(36):12879-84.<\/p>\n

Uit het laboratorium van Drs. Loren Fong en Steven Young van UCLA.<\/a> PRF heeft deze studie medegefinancierd.<\/em><\/p>\n

Fong LG, Frost D, Meta M, Qiao X, Yang SH, Coffinier C, et al. Een prote\u00efnefarnesyltransferaseremmer verlicht de ziekte in een muizenmodel van progeria.<\/em> Wetenschap 2006;311(5767):1621-3.<\/p>\n

Hier zijn slechts enkele van de vele media die over dit verhaal hebben bericht:<\/strong><\/p>\n

ABCNIEUWS.COM<\/strong>
Kankermedicijnen kunnen zeldzame ziekte die snel veroudert bestrijden: 29 september 2005 (artikel niet meer beschikbaar)
LA TIJDEN<\/strong>
Onderzoek toont aan dat medicijnen vroegtijdige verouderingsziekten kunnen blokkeren (artikel niet langer beschikbaar)
FORBES <\/strong>
Kankermedicijnen kunnen snelle verouderingsziekte bestrijden (artikel niet meer beschikbaar)
REUTERS<\/strong>
Kankermedicijnen kunnen verouderingssyndroom bij kinderen behandelen (artikel niet meer beschikbaar)
GEZONDHEIDSNIEUWSDIGEST.COM<\/strong>
Het blokkeren van een vroegtijdig verouderingssyndroom met antikankermedicijnen (artikel niet meer beschikbaar)<\/p>\n<\/div>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”3.22″][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.6.5″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” hover_enabled=”0″ sticky_enabled=”0″] August 2005 \u2013February 2006: Researchers have published studies that support a potential drug treatment for children with Progeria. Farnesyltransferase inhibitors (FTIs), originally developed for cancer, are capable of reversing the dramatic nuclear structure abnormalities that are the hallmark […]<\/p>","protected":false},"author":1,"featured_media":2043,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"

[vc_custom_heading text=\"Exciting News on Potential Drug Treatments\" font_container=\"tag:h1|text_align:left\" use_theme_fonts=\"yes\"]<\/p>

August 2005 \u2013February 2006: Researchers have published studies that support a potential drug treatment for children with Progeria. Farnesyltransferase inhibitors (FTIs), originally developed for cancer, are capable of reversing the dramatic nuclear structure abnormalities that are the hallmark of cells from children with Progeria.<\/p>

Here are some answers to Frequently Asked Questions about FTI's and these recent findings<\/a><\/strong><\/p>

From the lab of Susan Michaelis at Johns Hopkins University School of Medicine and the University of Seattle. First author: Monica Mallampalli.<\/a> PRF funded this study.<\/em> Click here<\/a> for the article \"<\/p>

From the lab of Dr. Thomas Glover at the University of Michigan.<\/a> First author: Michael W. Glynn. PRF funded this study.<\/em> Click here<\/a> for the article \"<\/p>

From the lab of Dr. Francis Collins at the National Human Genome Research Institute: First author: Brian Capell.<\/a> Additional author: PRF's Medical Director Dr. Leslie Gordon<\/em><\/p>

Capell BC, Erdos MR, Madigan JP, Fiordalisi JJ, Varga R, Conneely KN, et al. Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome.<\/em> Proc Natl Acad Sci U S A 2005;102(36):12879-84.<\/p>

From the lab of Drs. Loren Fong and Steven Young at UCLA.<\/a> PRF helped fund this study.<\/em><\/p>

Fong LG, Frost D, Meta M, Qiao X, Yang SH, Coffinier C, et al. A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria.<\/em> Science 2006;311(5767):1621-3.<\/p>

Here are just a few of the many media outlets that have covered this story:<\/strong><\/p>

ABCNEWS.COM<\/strong>
Cancer Drugs May Fight Rare Rapid-Aging Disease: Sept.29, 2005<\/a> (article no longer available)
LA TIMES<\/strong>
Research Shows Drugs Could Block Early-Aging Disease<\/a>
FORBES <\/strong>
Cancer Drugs May Fight Rapid-Aging Disease<\/a>\u00a0(article no longer available)
REUTERS<\/strong>
Cancer Drugs May Treat Aging Syndrome in Children<\/a> (article no longer available)
HEALTHNEWSDIGEST.COM<\/strong>
Blocking a Premature Aging Syndrome with Anticancer Drugs<\/a>\u00a0(article no longer available)<\/p>
You will need the Adobe Acrobat Plugin to view and print forms. 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