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PRF Research Program <\/span><\/strong><\/h1>\n

Related Publications<\/span><\/strong><\/h1>\n

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The Progeria Research Foundation (PRF) plays a vital role in promoting Progeria research by leading scientists around the world.\u00a0 Many publications by these scientists acknowledge PRF\u2019s programs.\u00a0 By providing funding through grants; supplying material and data from the Cell and Tissue Bank, Medical and Research Database and the International Progeria Registry; publishing findings from clinical drug trials; and hosting scientific workshops where researchers can discuss their latest findings, PRF continues to drive the research that will eventually lead to a cure for Progeria.<\/p>\n

Below is a list, by program, of the many publications that have acknowledged one or more of PRF\u2019s research programs.<\/p>\n

[\/et_pb_text][et_pb_toggle title=”PRF Cell and Tissue Bank” open_toggle_background_color=”#f7f7f7″ closed_toggle_text_color=”#ffffff” closed_toggle_background_color=”#00b2e2″ icon_color=”#ffc15e” open_icon_color=”#ffc15e” admin_label=”Cell and Tissue Bank” _builder_version=”4.27.5″ title_text_color=”#00b2e2″ background_color=”#ffffff” custom_margin=”40px||40px||true|false” custom_padding=”|50px||50px||true” animation_style=”slide” animation_direction=”top” animation_intensity_slide=”25%” link_option_url_new_window=”on” hover_enabled=”0″ z_index_tablet=”500″ border_width_all=”0px” global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

Publications Utilizing Material from <\/strong><\/h4>\n

The Progeria Research Foundation Cell and Tissue Bank<\/strong><\/h4>\n

2026<\/strong><\/p>\n

Ameliorating calcium homeostasis improves longevity and healthspan in progeroid and naturally aged mice<\/a><\/h5>\n

Xiang W, Hu Q, Sun P, et al.\u00a0Nat Commun<\/em>. Published online June 6, 2026. doi:10.1038\/s41467-026-74021-z<\/p>\n

Farnesylated prelamin A induces fibroblast polarity defects in premature aging disorders by inhibiting nesprin-2-SUN2 LINC complex function – PubMed<\/a><\/h5>\n

Lio C, Wang Y, Wilson PC, et al. J Cell Sci<\/em>. 2026;139(12):jcs264488. doi:10.1242\/jcs.264488<\/p>\n

A Long-lived Avatar for Modeling Age-Related Vascular Disease<\/a><\/h5>\n

Qin W, Tran TN, Xiao Y, et al. Preprint.\u00a0bioRxiv<\/em>. 2026;2026.04.29.721776. Published 2026 May 4. doi:10.64898\/2026.04.29.721776<\/p>\n

Increased Telomere Mobility in Progeria is Restored by Isoprenylcysteine Carboxyl Methyltransferase Inhibition<\/a><\/h5>\n

Gagliano G, Raterink A, Yang X, Berg\u00f6 M, Gustavsson AK. Preprint.\u00a0bioRxiv<\/em>. 2026;2026.04.25.720781. Published 2026 Apr 28. doi:10.64898\/2026.04.25.720781<\/p>\n

Detection of nuclear STING in cultured human cells and in the normal and cancer tissues<\/a><\/h5>\n

Vo N, Chen E, Sidorova JM.\u00a0iScience<\/em>. 2026;29(5):115711. Published 2026 Apr 10. doi:10.1016\/j.isci.2026.115711<\/p>\n

First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria<\/a><\/h5>\n

Macicior-Michelena J, Telechea M, Fern\u00e1ndez D, Garc\u00eda-Mart\u00edn A, Canales \u00c1, Ortega-Guti\u00e9rrez S.\u00a0Adv Sci (Weinh)<\/em>. Published online March 23, 2026. doi:10.1002\/advs.202521608<\/p>\n

Hutchinson-Gilford progeria syndrome alters the endothelial genetic response to laminar shear stress<\/a><\/h5>\n

Kennedy CC, Carter JL, Truskey GA.\u00a0Front Physiol<\/em>. 2026;16:1599339. Published 2026 Feb 24. doi:10.3389\/fphys.2025.1599339<\/p>\n

Senescence-inhibitory \u0394133p53\u03b1 counteracts accelerated ageing and mortality<\/a><\/h5>\n

Yamada L, Liu H, von Muhlinen N, Harris CC, Horikawa I. Preprint.\u00a0bioRxiv<\/em>. 2026;2025.12.31.697195. Published 2026 Jan 20. doi:10.64898\/2025.12.31.697195<\/p>\n

\n

2025<\/strong><\/p>\n

Selection of specific and efficient siRNAs in new cellular model for Hutchinson-Gilford progeria syndrome therapy<\/a><\/h5>\n

Dzianisava V, Piekarowicz K, Machowska M, Rzepecki R. Mol Ther Nucleic Acids<\/em>. 2025;36(4):102727. Published 2025 Oct 3. doi:10.1016\/j.omtn.2025.102727<\/p>\n

Generation of Nonintegrative-Induced Pluripotent Stem Cells in Hutchinson-Gilford Progeria Syndrome: Enhancing Aging Research<\/a><\/h5>\n

Kadiwala J, Shakur R.\u00a0Aging Med (Milton)<\/em>. 2025;8(5):493-498. Published 2025 Sep 22. doi:10.1002\/agm2.70041<\/p>\n

A longevity-associated variant of the human BPIFB4 gene prevents diastolic dysfunction in progeria mice<\/a><\/h5>\n

Qiu Y, Cattaneo M, Maciag A, Puca AA, Madeddu P.\u00a0Signal Transduct Target Ther<\/em>. 2025;10(1):314. Published 2025 Sep 29. doi:10.1038\/s41392-025-02416-3<\/p>\n

Manipulation of the nucleoscaffold potentiates cellular reprogramming kinetics<\/a><\/h5>\n

Yang BA, Vesga-Castro C, Monteiro da Rocha A, et al. PNAS Nexus<\/em>. 2025;4(10):pgaf307. Published 2025 Sep 25. doi:10.1093\/pnasnexus\/pgaf307<\/p>\n

Transcriptional profiling of Hutchinson-Gilford Progeria patients identifies primary target pathways of progerin<\/a><\/h5>\n

Vidak S, Kim S, Misteli T. Preprint.\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125. Published 2025 Sep 20. doi:10.1101\/2025.09.18.677125<\/p>\n

Deregulated miR-145 and miR-27b in hutchinson-gilford progeria syndrome: implications for adipogenesis<\/a><\/h5>\n

Fenzl FQ, Lederer EM, Brumma L, et al. Aging (Albany NY)<\/em>. Published online August 27, 2025. doi:10.18632\/aging.206309<\/p>\n

Impact of miR-181a on SIRT1 Expression and Senescence in Hutchinson-Gilford Progeria Syndrome<\/a><\/h5>\n

Lederer EM, Fenzl FQ, Kr\u00fcger P, Schroll M, Hartinger R, Djabali K. Diseases<\/em>. 2025;13(8):245. Published 2025 Aug 4. doi:10.3390\/diseases13080245<\/p>\n

A Quantitative High-Throughput Screen Identifies Compounds that Upregulate the p53 Isoform \u0394133p53\u03b1 and Inhibit Cellular Senescence<\/a><\/h5>\n

Lissa D, Joruiz SM, Dranchak PK, et al.\u00a0ACS Pharmacol Transl Sci<\/em>. 2025;8(7):2061-2074. Published 2025 Jun 20. doi:10.1021\/acsptsci.5c00186<\/p>\n

Pharmacologic activation of \u0394133p53\u03b1 reduces cellular senescence in progeria patients-derived cells<\/a><\/h5>\n

Joruiz SM, Lissa D, Von Muhlinen N, et al. Preprint.\u00a0bioRxiv<\/em>. 2025;2025.07.28.667224. Published 2025 Aug 2. doi:10.1101\/2025.07.28.667224<\/p>\n

Patient-Derived Cortical Organoids Reveal Senescence of Neural Progenitor Cells in Hutchinson-Gilford Progeria Syndrome<\/a><\/strong><\/h5>\n

Jeon S, Park CS, Hong J, et al.\u00a0Aging Cell<\/em>. Published online June 30, 2025.<\/p>\n

Baricitinib and Lonafarnib Synergistically Target Progerin and Inflammation, Improving Lifespan and Health in Progeria Mice<\/a><\/strong><\/h5>\n

Kr\u00fcger P, Schroll M, Fenzl FQ, et al.\u00a0Int J Mol Sci<\/em>. 2025;26(10):4849. Published 2025 May 19. doi:10.3390\/ijms26104849<\/p>\n

Hutchinson-Gilford Progeria Syndrome<\/a><\/h5>\n

Gordon LB, Brown WT, Collins FS. 2003 Dec 12 [Updated 2025 Mar 13]. In: Adam MP, Feldman J, Mirzaa GM, et al., editors. GeneReviews\u00ae [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2025.<\/p>\n

Circular RNA Telomerase Reverses Endothelial Senescence in Progeria<\/a><\/h5>\n

Qin W, Castillo KD, Li H, et al.\u00a0Aging Cell<\/em>. Published online February 23, 2025. doi:10.1111\/acel.70021<\/p>\n

Adenine base editing rescues pathogenic phenotypes in tissue engineered vascular model of Hutchinson-Gilford progeria syndrome<\/a><\/h5>\n

Abutaleb NO, Gao XD, Bedapudi A, et al. APL Bioeng<\/em>. 2025;9(1):016110. Published 2025 Feb 26. doi:10.1063\/5.0244026<\/p>\n

\n

2024<\/strong><\/p>\n

Aged-vascular niche hinders osteogenesis of mesenchymal stem cells through paracrine repression of Wnt-axis<\/a><\/h5>\n

Fleischhacker V, Milosic F, Bricelj M, et al. Aging Cell<\/em>. 2024;23(6):e14139. doi:10.1111\/acel.14139<\/p>\n

Aberrant migration features in primary skin fibroblasts of Huntington’s disease patients hold potential for unraveling disease progression using an image based machine learning tool<\/a><\/h5>\n

Gharaba S, Shalem A, Paz O, Muchtar N, Wolf L, Weil M. Comput Biol Med<\/em>. 2024;180:108970. doi:10.1016\/j.compbiomed.2024.108970<\/p>\n

Enhancing Cellular Homeostasis: Targeted Botanical Compounds Boost Cellular Health Functions in Normal and Premature Aging Fibroblasts<\/a><\/h5>\n

Hartinger R, Singh K, Leverett J, Djabali K. Biomolecules<\/em>. 2024;14(10):1310. Published 2024 Oct 16. doi:10.3390\/biom14101310<\/p>\n

The NLRP3 inhibitor Dapansutrile improves the therapeutic action of lonafarnib on progeroid mice<\/a><\/h5>\n

Muela-Zarzuela I, Suarez-Rivero JM, Boy-Ruiz D, et al. Aging Cell<\/em>. 2024;23(9):e14272. doi:10.1111\/acel.14272<\/p>\n

Progeria-based vascular model identifies networks associated with cardiovascular aging and disease<\/a><\/h5>\n

Ngubo M, Chen Z, McDonald D, et al. Aging Cell<\/em>. 2024;23(7):e14150. doi:10.1111\/acel.14150<\/p>\n

Angiopoietin-2 reverses endothelial cell dysfunction in progeria vasculature<\/a><\/h5>\n

Vakili S, Izydore EK, Losert L, et al. Aging Cell<\/em>. 2025;24(2):e14375. doi:10.1111\/acel.14375<\/p>\n

Progerin mRNA expression in non-HGPS patients is correlated with widespread shifts in transcript isoforms<\/a><\/h5>\n

Yu R, Xue H, Lin W, Collins FS, Mount SM, Cao K. NAR Genom Bioinform<\/em>. 2024;6(3):lqae115. Published 2024 Aug 29. doi:10.1093\/nargab\/lqae115<\/p>\n

Coaching ribosome biogenesis from the nuclear periphery<\/a><\/h5>\n

Zhuang Y, Guo X, Razorenova OV, Miles CE, Zhao W, Shi X. Preprint.\u00a0bioRxiv<\/em>. 2024;2024.06.21.597078. Published 2024 Jun 22. doi:10.1101\/2024.06.21.597078<\/p>\n

\n

2023<\/strong><\/p>\n

Lonafarnib and everolimus reduce pathology in iPSC-derived tissue engineered blood vessel model of Hutchinson-Gilford Progeria Syndrome<\/a><\/h5>\n

Abutaleb NO, Atchison L, Choi L, et al. Sci Rep<\/em>. 2023;13(1):5032. Published 2023 Mar 28. doi:10.1038\/s41598-023-32035-3<\/p>\n

Aging Model for Analyzing Drug-Induced Proarrhythmia Risks Using Cardiomyocytes Differentiated from Progeria-Patient-Derived Induced Pluripotent Stem Cells<\/a><\/h5>\n

Daily N, Elson J, Wakatsuki T. Int J Mol Sci<\/em>. 2023;24(15):11959. Published 2023 Jul 26. doi:10.3390\/ijms241511959<\/p>\n

Ghrelin delays premature aging in Hutchinson-Gilford progeria syndrome<\/a><\/h5>\n

Ferreira-Marques M, Carvalho A, Franco AC, et al. Aging Cell<\/em>. 2023;22(12):e13983. doi:10.1111\/acel.13983<\/p>\n

Perturbed actin cap as a new personalized biomarker in primary fibroblasts of Huntington’s disease patients<\/a><\/h5>\n

Gharaba S, Paz O, Feld L, et al. Front Cell Dev Biol<\/em>. 2023;11:1013721. Published 2023 Jan 18. doi:10.3389\/fcell.2023.1013721<\/p>\n

Plasma Progerin in Patients With Hutchinson-Gilford Progeria Syndrome: Immunoassay Development and Clinical Evaluation<\/a><\/h5>\n

Gordon LB, Norris W, Hamren S, et al. Circulation<\/em>. 2023;147(23):1734-1744. doi:10.1161\/CIRCULATIONAHA.122.060002<\/p>\n

Impact of Combined Baricitinib and FTI Treatment on Adipogenesis in Hutchinson-Gilford Progeria Syndrome and Other Lipodystrophic Laminopathies<\/a><\/h5>\n

Hartinger R, Lederer EM, Schena E, Lattanzi G, Djabali K. Cells<\/em>. 2023;12(10):1350. Published 2023 May 9. doi:10.3390\/cells12101350<\/p>\n

Lonafarnib improves cardiovascular function and survival in a mouse model of Hutchinson-Gilford progeria syndrome<\/a><\/h5>\n

Murtada SI, Mikush N, Wang M, et al. Elife<\/em>. 2023;12:e82728. Published 2023 Mar 17. doi:10.7554\/eLife.82728<\/p>\n

The farnesyl transferase inhibitor (FTI) lonafarnib improves nuclear morphology in ZMPSTE24-deficient fibroblasts from patients with the progeroid disorder MAD-B<\/a><\/h5>\n

Odinammadu KO, Shilagardi K, Tuminelli K, Judge DP, Gordon LB, Michaelis S. Nucleus<\/em>. 2023;14(1):2288476. doi:10.1080\/19491034.2023.2288476<\/p>\n

Hutchinson-Gilford progeria patient-derived cardiomyocyte model of carrying LMNA gene variant c.1824 C > T<\/a><\/h5>\n

Perales S, Sigamani V, Rajasingh S, Czirok A, Rajasingh J. Cell Tissue Res<\/em>. 2023;394(1):189-207. doi:10.1007\/s00441-023-03813-2<\/p>\n

Remodeling of the Cardiac Extracellular Matrix Proteome During Chronological and Pathological Aging<\/a><\/h5>\n

Santinha D, Vila\u00e7a A, Estronca L, et al. Mol Cell Proteomics<\/em>. 2024;23(1):100706. doi:10.1016\/j.mcpro.2023.100706<\/p>\n

Activation of endoplasmic reticulum stress in premature aging via the inner nuclear membrane protein SUN2<\/a><\/h5>\n

Vidak S, Serebryannyy LA, Pegoraro G, Misteli T. Cell Rep<\/em>. 2023;42(5):112534. doi:10.1016\/j.celrep.2023.112534<\/p>\n

Unique progerin C-terminal peptide ameliorates Hutchinson-Gilford progeria syndrome phenotype by rescuing BUBR1<\/a><\/h5>\n

Zhang N, Hu Q, Sui T, et al. [published correction appears in Nat Aging. 2023 Jun;3(6):752. doi: 10.1038\/s43587-023-00427-9].\u00a0Nat Aging<\/em>. 2023;3(2):185-201. doi:10.1038\/s43587-023-00361-w<\/p>\n

Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models<\/a><\/h5>\n

Zonari A, Brace LE, Al-Katib K, et al. [published correction appears in NPJ Aging. 2024 Feb 15;10(1):14. doi: 10.1038\/s41514-024-00140-w].\u00a0NPJ Aging<\/em>. 2023;9(1):10. Published 2023 May 22. doi:10.1038\/s41514-023-00109-1<\/p>\n

\n

2022<\/strong><\/p>\n

Quantification of Farnesylated Progerin in Hutchinson-Gilford Progeria Patient Cells by Mass Spectrometry<\/a><\/h5>\n

Camafeita E, Jorge I, Rivera-Torres J, Andr\u00e9s V, V\u00e1zquez J. Int J Mol Sci<\/em>. 2022;23(19):11733. Published 2022 Oct 3. doi:10.3390\/ijms231911733<\/p>\n

SerpinE1 drives a cell-autonomous pathogenic signaling in Hutchinson-Gilford progeria syndrome<\/a><\/h5>\n

Catarinella G, Nicoletti C, Bracaglia A, et al. Cell Death Dis<\/em>. 2022;13(8):737. Published 2022 Aug 26. doi:10.1038\/s41419-022-05168-y<\/p>\n

Clonal hematopoiesis is not prevalent in Hutchinson-Gilford progeria syndrome<\/a><\/h5>\n

D\u00edez-D\u00edez M, Amor\u00f3s-P\u00e9rez M, de la Barrera J, et al.\u00a0Geroscience<\/em>. 2023;45(2):1231-1236. doi:10.1007\/s11357-022-00607-2<\/p>\n

MG132 Induces Progerin Clearance and Improves Disease Phenotypes in HGPS-like Patients’ Cells<\/a><\/h5>\n

Harhouri K, Cau P, Casey F, et al. Cells<\/em>. 2022;11(4):610. Published 2022 Feb 10. doi:10.3390\/cells11040610<\/p>\n

Anti-hsa-miR-59 alleviates premature senescence associated with Hutchinson-Gilford progeria syndrome in mice<\/a><\/h5>\n

Hu Q, Zhang N, Sui T, et al. EMBO J<\/em>. 2023;42(1):e110937. doi:10.15252\/embj.2022110937<\/p>\n

Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP<\/a><\/h5>\n

La Torre M, Merigliano C, Maccaroni K, et al. J Exp Clin Cancer Res<\/em>. 2022;41(1):273. Published 2022 Sep 13. doi:10.1186\/s13046-022-02480-5<\/p>\n

Establishment and Characterization of hTERT Immortalized Hutchinson-Gilford Progeria Fibroblast Cell Lines<\/a><\/h5>\n

Lin H, Mensch J, Haschke M, et al.\u00a0Cells<\/em>. 2022;11(18):2784. Published 2022 Sep 6. doi:10.3390\/cells11182784<\/p>\n

Impaired LEF1 Activation Accelerates iPSC-Derived Keratinocytes Differentiation in Hutchinson-Gilford Progeria Syndrome<\/a><\/h5>\n

Mao X, Xiong ZM, Xue H, et al.\u00a0Int J Mol Sci<\/em>. 2022;23(10):5499. Published 2022 May 14. doi:10.3390\/ijms23105499<\/p>\n

Modelling premature cardiac aging with induced pluripotent stem cells from a hutchinson-gilford Progeria Syndrome patient<\/a><\/h5>\n

Monnerat G, Kasai-Brunswick TH, Asensi KD, et al.\u00a0Front Physiol<\/em>. 2022;13:1007418. Published 2022 Nov 23. doi:10.3389\/fphys.2022.1007418<\/p>\n

Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate<\/a><\/h5>\n

Pfeifer CR, Tobin MP, Cho S, et al. Nucleus<\/em>. 2022;13(1):129-143. doi:10.1080\/19491034.2022.2045726<\/p>\n

Transcriptional profiling of Hutchinson-Gilford Progeria syndrome fibroblasts reveals deficits in mesenchymal stem cell commitment to differentiation related to early events in endochondral ossification<\/a><\/h5>\n

San Martin R, Das P, Sanders JT, Hill AM, McCord RP. Elife<\/em>. 2022;11:e81290. Published 2022 Dec 29. doi:10.7554\/eLife.81290<\/p>\n

Impact of MnTBAP and Baricitinib Treatment on Hutchinson-Gilford Progeria Fibroblasts<\/a><\/h5>\n

Vehns E, Arnold R, Djabali K. Pharmaceuticals (Basel)<\/em>. 2022;15(8):945. Published 2022 Jul 29. doi:10.3390\/ph15080945<\/p>\n

Achieving single nucleotide sensitivity in direct hybridization genome imaging<\/a><\/h5>\n

Wang Y, Cottle WT, Wang H, et al. Nat Commun<\/em>. 2022;13(1):7776. Published 2022 Dec 15. doi:10.1038\/s41467-022-35476-y<\/p>\n

Vascular senescence in progeria: role of endothelial dysfunction<\/a><\/h5>\n

Xu Q, Mojiri A, Boulahouache L, Morales E, Walther BK, Cooke JP. Vascular senescence in progeria: role of endothelial dysfunction.\u00a0Eur Heart J Open<\/em>. 2022;2(4):oeac047. Published 2022 Jul 28. doi:10.1093\/ehjopen\/oeac047<\/strong><\/p>\n

\n

2021<\/strong><\/p>\n

Baricitinib, a JAK-STAT Inhibitor, Reduces the Cellular Toxicity of the Farnesyltransferase Inhibitor Lonafarnib in Progeria Cells<\/a><\/h5>\n

Arnold R, Vehns E, Randl H, Djabali K. Int J Mol Sci<\/em>. 2021;22(14):7474. Published 2021 Jul 12. doi:10.3390\/ijms22147474<\/p>\n

A targeted antisense therapeutic approach for Hutchinson-Gilford progeria syndrome<\/a><\/h5>\n

Erdos MR, Cabral WA, Tavarez UL, et al. Nat Med<\/em>. 2021;27(3):536-545. doi:10.1038\/s41591-021-01274-0<\/p>\n

Self-assembly of multi-component mitochondrial nucleoids via phase separation<\/a><\/h5>\n

Feric M, Demarest TG, Tian J, Croteau DL, Bohr VA, Misteli T. EMBO J<\/em>. 2021;40(6):e107165. doi:10.15252\/embj.2020107165<\/p>\n

Mechanisms of angiogenic incompetence in Hutchinson-Gilford progeria via downregulation of endothelial NOS<\/a><\/h5>\n

Gete YG, Koblan LW, Mao X, et al. Aging Cell<\/em>. 2021;20(7):e13388. doi:10.1111\/acel.13388<\/p>\n

Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson-Gilford Progeria<\/a><\/h5>\n

Gonz\u00e1lez-Dominguez A, Monta\u00f1ez R, Castej\u00f3n-Vega B, et al.\u00a0EMBO Mol Med<\/em>. 2021;13(10):e14012. doi:10.15252\/emmm.202114012<\/p>\n

Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome<\/a><\/h5>\n

Kang SM, Yoon MH, Ahn J, et al. [published correction appears in Commun Biol. 2021 Mar 2;4(1):297. doi: 10.1038\/s42003-021-01843-6.].\u00a0Commun Biol<\/em>. 2021;4(1):5. Published 2021 Jan 4. doi:10.1038\/s42003-020-01540-w<\/p>\n

In vivo base editing rescues Hutchinson-Gilford progeria syndrome in mice<\/a><\/h5>\n

Koblan LW, Erdos MR, Wilson C, et al. Nature<\/em>. 2021;589(7843):608-614. doi:10.1038\/s41586-020-03086-7<\/p>\n

Isoprenylcysteine Carboxylmethyltransferase-Based Therapy for Hutchinson-Gilford Progeria Syndrome<\/a><\/h5>\n

Marcos-Ramiro B, Gil-Ord\u00f3\u00f1ez A, Mar\u00edn-Ramos NI, et al. ACS Cent Sci<\/em>. 2021;7(8):1300-1310. doi:10.1021\/acscentsci.0c01698<\/p>\n

Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice<\/a><\/h5>\n

Mojiri A, Walther BK, Jiang C, et al. Eur Heart J<\/em>. 2021;42(42):4352-4369. doi:10.1093\/eurheartj\/ehab547<\/p>\n

Impact of Progerin Expression on Adipogenesis in Hutchinson-Gilford Progeria Skin-Derived Precursor Cells<\/a><\/h5>\n

Najdi F, Kr\u00fcger P, Djabali K. Cells<\/em>. 2021;10(7):1598. Published 2021 Jun 25. doi:10.3390\/cells10071598<\/p>\n

Systematic screening identifies therapeutic antisense oligonucleotides for Hutchinson-Gilford progeria syndrome<\/a><\/h5>\n

Puttaraju M, Jackson M, Klein S, et al. [published correction appears in Nat Med. 2021 Jul;27(7):1309. doi: 10.1038\/s41591-021-01415-5.].\u00a0Nat Med<\/em>. 2021;27(3):526-535. doi:10.1038\/s41591-021-01262-4<\/p>\n

Nuclear Pore Complexes Cluster in Dysmorphic Nuclei of Normal and Progeria Cells during Replicative Senescence<\/a><\/h5>\n

R\u00f6hrl JM, Arnold R, Djabali K. Cells<\/em>. 2021;10(1):153. Published 2021 Jan 14. doi:10.3390\/cells10010153<\/p>\n

\n

2020<\/strong><\/p>\n

iPSC-Derived Endothelial Cells Affect Vascular Function in a Tissue-Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome<\/a><\/h5>\n

Atchison L, Abutaleb NO, Snyder-Mounts E, et al. Stem Cell Reports<\/em>. 2020;14(2):325-337. doi:10.1016\/j.stemcr.2020.01.005<\/p>\n

Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome<\/a><\/h5>\n

Bersini S, Schulte R, Huang L, Tsai H, Hetzer MW. Elife<\/em>. 2020;9:e54383. Published 2020 Sep 8. doi:10.7554\/eLife.54383<\/p>\n

Phosphorylated Lamin A\/C in the Nuclear Interior Binds Active Enhancers Associated with Abnormal Transcription in Progeria<\/a><\/h5>\n

Ikegami K, Secchia S, Almakki O, Lieb JD, Moskowitz IP. Dev Cell<\/em>. 2020;52(6):699-713.e11. doi:10.1016\/j.devcel.2020.02.011<\/p>\n

Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome<\/a><\/h5>\n

K\u00f6hler F, Bormann F, Raddatz G, et al. Genome Med<\/em>. 2020;12(1):46. Published 2020 May 25. doi:10.1186\/s13073-020-00749-y<\/p>\n

Chromatin and Cytoskeletal Tethering Determine Nuclear Morphology in Progerin-Expressing Cells<\/a><\/h5>\n

Lionetti MC, Bonfanti S, Fumagalli MR, et al. Biophys J<\/em>. 2020;118(9):2319-2332. doi:10.1016\/j.bpj.2020.04.001<\/p>\n

Peroxisomal abnormalities and catalase deficiency in Hutchinson-Gilford Progeria Syndrome<\/a><\/h5>\n

Mao X, Bharti P, Thaivalappil A, Cao K. Aging (Albany NY)<\/em>. 2020;12(6):5195-5208. doi:10.18632\/aging.102941<\/p>\n

SAMMY-seq reveals early alteration of heterochromatin and deregulation of bivalent genes in Hutchinson-Gilford Progeria Syndrome<\/a><\/h5>\n

Sebesty\u00e9n E, Marullo F, Lucini F, et al. Nat Commun<\/em>. 2020;11(1):6274. Published 2020 Dec 8. doi:10.1038\/s41467-020-20048-9<\/p>\n

PML2-mediated thread-like nuclear bodies mark late senescence in Hutchinson-Gilford progeria syndrome<\/a><\/h5>\n

Wang M, Wang L, Qian M, et al. Aging Cell<\/em>. 2020;19(6):e13147. doi:10.1111\/acel.13147<\/p>\n

Targeting RAS-converting enzyme 1 overcomes senescence and improves progeria-like phenotypes of ZMPSTE24 deficiency<\/a><\/h5>\n

Yao H, Chen X, Kashif M, et al. Aging Cell<\/em>. 2020;19(8):e13200. doi:10.1111\/acel.13200<\/p>\n

\n

2019<\/strong><\/p>\n

Imbalanced nucleocytoskeletal connections create common polarity defects in progeria and physiological aging<\/a><\/h5>\n

Chang W, Wang Y, Luxton GWG, \u00d6stlund C, Worman HJ, Gundersen GG. Proc Natl Acad Sci U S A<\/em>. 2019;116(9):3578-3583. doi:10.1073\/pnas.1809683116<\/p>\n

Transient introduction of human telomerase mRNA improves hallmarks of progeria cells<\/a><\/h5>\n

Li Y, Zhou G, Bruno IG, et al. Aging Cell<\/em>. 2019;18(4):e12979. doi:10.1111\/acel.12979<\/p>\n

Inhibition of JAK-STAT Signaling with Baricitinib Reduces Inflammation and Improves Cellular Homeostasis in Progeria Cells<\/a><\/h5>\n

Liu C, Arnold R, Henriques G, Djabali K. Cells<\/em>. 2019;8(10):1276. Published 2019 Oct 18. doi:10.3390\/cells8101276<\/p>\n

Dysfunction of iPSC-derived endothelial cells in human Hutchinson-Gilford progeria syndrome<\/a><\/h5>\n

Matrone G, Thandavarayan RA, Walther BK, Meng S, Mojiri A, Cooke JP. Cell Cycle<\/em>. 2019;18(19):2495-2508. doi:10.1080\/15384101.2019.1651587<\/p>\n

Metabolomic profiling suggests systemic signatures of premature aging induced by Hutchinson-Gilford progeria syndrome<\/a><\/h5>\n

Monnerat G, Evaristo GPC, Evaristo JAM, et al. Metabolomics<\/em>. 2019;15(7):100. Published 2019 Jun 28. doi:10.1007\/s11306-019-1558-6<\/p>\n

Analysis of somatic mutations identifies signs of selection during in vitro aging of primary dermal fibroblasts<\/a><\/h5>\n

Narisu N, Rothwell R, Vrta\u010dnik P, et al. Aging Cell<\/em>. 2019;18(6):e13010. doi:10.1111\/acel.13010<\/p>\n

Restoring extracellular matrix synthesis in senescent stem cells<\/a><\/h5>\n

Rong N, Mistriotis P, Wang X, et al. FASEB J<\/em>. 2019;33(10):10954-10965. doi:10.1096\/fj.201900377R<\/strong><\/p>\n

\n

2018<\/strong><\/p>\n

Smurf2 regulates stability and the autophagic-lysosomal turnover of lamin A and its disease-associated form progerin<\/a><\/h5>\n

Borroni AP, Emanuelli A, Shah PA, et al. Aging Cell<\/em>. 2018;17(2):e12732. doi:10.1111\/acel.12732<\/p>\n

Progerin phosphorylation in interphase is lower and less mechanosensitive than lamin-A,C in iPS-derived mesenchymal stem cells<\/a><\/h5>\n

Cho S, Abbas A, Irianto J, et al. Nucleus<\/em>. 2018;9(1):230-245. doi:10.1080\/19491034.2018.1460185<\/p>\n

Diminished Canonical \u03b2-Catenin Signaling During Osteoblast Differentiation Contributes to Osteopenia in Progeria<\/a><\/h5>\n

Choi JY, Lai JK, Xiong ZM, et al. J Bone Miner Res<\/em>. 2018;33(11):2059-2070. doi:10.1002\/jbmr.3549<\/p>\n

Everolimus rescues multiple cellular defects in laminopathy-patient fibroblasts<\/a><\/h5>\n

DuBose AJ, Lichtenstein ST, Petrash NM, Erdos MR, Gordon LB, Collins FS. [published correction appears in Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4140. doi: 10.1073\/pnas.1805694115.].\u00a0Proc Natl Acad Sci U S A<\/em>. 2018;115(16):4206-4211. doi:10.1073\/pnas.1802811115<\/p>\n

Predicting age from the transcriptome of human dermal fibroblasts<\/a><\/h5>\n

Fleischer JG, Schulte R, Tsai HH, et al. Genome Biol<\/em>. 2018;19(1):221. Published 2018 Dec 20. doi:10.1186\/s13059-018-1599-6<\/p>\n

Targeting the phospholipase A2 receptor ameliorates premature aging phenotypes<\/a><\/h5>\n

Griveau A, Wiel C, Le Calv\u00e9 B, et al. Aging Cell<\/em>. 2018;17(6):e12835. doi:10.1111\/acel.12835<\/p>\n

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies<\/a><\/h5>\n

Horvath S, Oshima J, Martin GM, et al. Aging (Albany NY)<\/em>. 2018;10(7):1758-1775. doi:10.18632\/aging.101508<\/p>\n

A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin<\/a><\/h5>\n

Kreienkamp R, Graziano S, Coll-Bonfill N, et al. Cell Rep<\/em>. 2018;22(8):2006-2015. doi:10.1016\/j.celrep.2018.01.090<\/p>\n

Analyses of LMNA-negative juvenile progeroid cases confirms biallelic POLR3A mutations in Wiedemann-Rautenstrauch-like syndrome and expands the phenotypic spectrum of PYCR1 mutations<\/a><\/h5>\n

Lessel D, Ozel AB, Campbell SE, et al.\u00a0Hum Genet<\/em>. 2018;137(11-12):921-939. doi:10.1007\/s00439-018-1957-1<\/p>\n

Autophagic Removal of Farnesylated Carboxy-Terminal Lamin Peptides<\/a><\/h5>\n

Lu X, Djabali K. Cells<\/em>. 2018;7(4):33. Published 2018 Apr 23. doi:10.3390\/cells7040033<\/p>\n

p53 isoforms regulate premature aging in human cells<\/a><\/h5>\n

von Muhlinen N, Horikawa I, Alam F, et al. Oncogene<\/em>. 2018;37(18):2379-2393. doi:10.1038\/s41388-017-0101-3<\/p>\n

\n

2017<\/strong><\/p>\n

SIRPA-Inhibited, Marrow-Derived Macrophages Engorge, Accumulate, and Differentiate in Antibody-Targeted Regression of Solid Tumors<\/a><\/h5>\n

Alvey CM, Spinler KR, Irianto J, et al. Curr Biol<\/em>. 2017;27(14):2065-2077.e6. doi:10.1016\/j.cub.2017.06.005<\/p>\n

Nucleolar expansion and elevated protein translation in premature aging<\/a><\/h5>\n

Buchwalter A, Hetzer MW. Nat Commun<\/em>. 2017;8(1):328. Published 2017 Aug 30. doi:10.1038\/s41467-017-00322-z<\/p>\n

Reprogramming progeria fibroblasts re-establishes a normal epigenetic landscape<\/a><\/h5>\n

Chen Z, Chang WY, Etheridge A, et al. Aging Cell<\/em>. 2017;16(4):870-887. doi:10.1111\/acel.12621<\/p>\n

Intermittent treatment with farnesyltransferase inhibitor and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts<\/a><\/h5>\n

Gabriel D, Shafry DD, Gordon LB, Djabali K. Oncotarget<\/em>. 2017;8(39):64809-64826. Published 2017 Jul 18. doi:10.18632\/oncotarget.19363<\/p>\n

Progerin sequestration of PCNA promotes replication fork collapse and mislocalization of XPA in laminopathy-related progeroid syndromes<\/a><\/h5>\n

Hilton BA, Liu J, Cartwright BM, et al. FASEB J<\/em>. 2017;31(9):3882-3893. doi:10.1096\/fj.201700014R<\/p>\n

Cross-linked matrix rigidity and soluble retinoids synergize in nuclear lamina regulation of stem cell differentiation<\/a><\/h5>\n

Ivanovska IL, Swift J, Spinler K, Dingal D, Cho S, Discher DE. Mol Biol Cell<\/em>. 2017;28(14):2010-2022. doi:10.1091\/mbc.E17-01-0010<\/p>\n

Identification of novel PDE\u03b4 interacting proteins<\/a><\/h5>\n

K\u00fcchler P, Zimmermann G, Winzker M, Janning P, Waldmann H, Ziegler S. Bioorg Med Chem<\/em>. 2018;26(8):1426-1434. doi:10.1016\/j.bmc.2017.08.033<\/p>\n

Telomerase mRNA Reverses Senescence in Progeria Cells<\/a><\/h5>\n

Li Y, Zhou G, Bruno IG, Cooke JP. J Am Coll Cardiol<\/em>. 2017;70(6):804-805. doi:10.1016\/j.jacc.2017.06.017<\/p>\n

Metformin alleviates ageing cellular phenotypes in Hutchinson-Gilford progeria syndrome dermal fibroblasts<\/a><\/h5>\n

Park SK, Shin OS. Exp Dermatol<\/em>. 2017;26(10):889-895. doi:10.1111\/exd.13323<\/p>\n

Nucleoplasmic lamins define growth-regulating functions of lamina-associated polypeptide 2\u03b1 in progeria cells<\/a><\/h5>\n

Vidak S, Georgiou K, Fichtinger P, Naetar N, Dechat T, Foisner R. J Cell Sci<\/em>. 2018;131(3):jcs208462. Published 2018 Feb 8. doi:10.1242\/jcs.208462<\/p>\n

\n

2016<\/strong><\/p>\n

A novel somatic mutation achieves partial rescue in a child with Hutchinson-Gilford progeria syndrome<\/a><\/h5>\n

Bar DZ, Arlt MF, Brazier JF, et al. J Med Genet<\/em>. 2017;54(3):212-216. doi:10.1136\/jmedgenet-2016-104295<\/p>\n

Progerin impairs chromosome maintenance by depleting CENP-F from metaphase kinetochores in Hutchinson-Gilford progeria fibroblasts<\/a><\/h5>\n

Eisch V, Lu X, Gabriel D, Djabali K. Oncotarget<\/em>. 2016;7(17):24700-24718. doi:10.18632\/oncotarget.8267<\/p>\n

Temsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular Phenotype<\/a><\/h5>\n

Gabriel D, Gordon LB, Djabali K. PLoS One<\/em>. 2016;11(12):e0168988. Published 2016 Dec 29. doi:10.1371\/journal.pone.0168988<\/p>\n

Vitamin D receptor signaling improves Hutchinson-Gilford progeria syndrome cellular phenotypes<\/a><\/h5>\n

Kreienkamp R, Croke M, Neumann MA, et al. Oncotarget<\/em>. 2016;7(21):30018-30031. doi:10.18632\/oncotarget.9065<\/p>\n

NANOG Reverses the Myogenic Differentiation Potential of Senescent Stem Cells by Restoring ACTIN Filamentous Organization and SRF-Dependent Gene Expression<\/a><\/h5>\n

Mistriotis P, Bajpai VK, Wang X, et al. Stem Cells<\/em>. 2017;35(1):207-221. doi:10.1002\/stem.2452<\/p>\n

Permanent farnesylation of lamin A mutants linked to progeria impairs its phosphorylation at serine 22 during interphase<\/a><\/h5>\n

Moiseeva O, Lopes-Paciencia S, Huot G, Lessard F, Ferbeyre G. Aging (Albany NY)<\/em>. 2016;8(2):366-381. doi:10.18632\/aging.100903<\/p>\n

A mutation abolishing the ZMPSTE24 cleavage site in prelamin A causes a progeroid disorder<\/a><\/h5>\n

Wang Y, Lichter-Konecki U, Anyane-Yeboa K, et al. J Cell Sci<\/em>. 2016;129(10):1975-1980. doi:10.1242\/jcs.187302<\/p>\n

Comparing lamin proteins post-translational relative stability using a 2A peptide-based system reveals elevated resistance of progerin to cellular degradation<\/a><\/h5>\n

Wu D, Yates PA, Zhang H, Cao K. Nucleus<\/em>. 2016;7(6):585-596.<\/p>\n

doi:10.1080\/19491034.2016.1260803<\/p>\n

Loss of H3K9me3 Correlates with ATM Activation and Histone H2AX Phosphorylation Deficiencies in Hutchinson-Gilford Progeria Syndrome<\/a><\/h5>\n

Zhang H, Sun L, Wang K, et al. PLoS One<\/em>. 2016;11(12):e0167454. Published 2016 Dec 1. doi:10.1371\/journal.pone.0167454<\/strong><\/p>\n

\n

2015<\/strong><\/p>\n

Nuclear stiffening and chromatin softening with progerin expression leads to an attenuated nuclear response to force<\/a><\/h5>\n

Booth EA, Spagnol ST, Alcoser TA, Dahl KN. Soft Matter<\/em>. 2015;11(32):6412-6418. doi:10.1039\/c5sm00521c<\/p>\n

Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair<\/a><\/h5>\n

Ghosh S, Liu B, Wang Y, Hao Q, Zhou Z. Cell Rep<\/em>. 2015;13(7):1396-1406. doi:10.1016\/j.celrep.2015.10.006<\/p>\n

Insights into the role of immunosenescence during varicella zoster virus infection (shingles) in the aging cell model<\/a><\/h5>\n

Kim JA, Park SK, Kumar M, Lee CH, Shin OS. Oncotarget<\/em>. 2015;6(34):35324-35343. doi:10.18632\/oncotarget.6117<\/p>\n

Proliferation of progeria cells is enhanced by lamina-associated polypeptide 2\u03b1 (LAP2\u03b1) through expression of extracellular matrix proteins<\/a><\/h5>\n

Vidak S, Kubben N, Dechat T, Foisner R. Genes Dev<\/em>. 2015;29(19):2022-2036. doi:10.1101\/gad.263939.115<\/p>\n

Phenotype-Dependent Coexpression Gene Clusters: Application to Normal and Premature Ageing<\/a><\/h5>\n

Wang K, Das A, Xiong ZM, Cao K, Hannenhalli S. IEEE\/ACM Trans Comput Biol Bioinform<\/em>. 2015;12(1):30-39. doi:10.1109\/TCBB.2014.2359446<\/p>\n

Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria<\/a><\/h5>\n

Xiong ZM, Choi JY, Wang K, et al. Aging Cell<\/em>. 2016;15(2):279-290. doi:10.1111\/acel.12434<\/p>\n

\n

2014<\/strong><\/p>\n

Sulforaphane enhances progerin clearance in Hutchinson-Gilford progeria fibroblasts<\/a><\/h5>\n

Gabriel D, Roedl D, Gordon LB, Djabali K. Aging Cell<\/em>. 2015;14(1):78-91. doi:10.1111\/acel.12300<\/p>\n

Mechanisms controlling the smooth muscle cell death in progeria via down-regulation of poly(ADP-ribose) polymerase 1<\/a><\/p>\n

Zhang H, Xiong ZM, Cao K. Proc Natl Acad Sci U S A<\/em>. 2014;111(22):E2261-E2270. doi:10.1073\/pnas.1320843111<\/p>\n

\n

2013<\/strong><\/p>\n

Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model<\/a><\/h5>\n

Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z. Nat Commun<\/em>. 2013;4:1868. doi:10.1038\/ncomms2885<\/p>\n

Correlated alterations in genome organization, histone methylation, and DNA-lamin A\/C interactions in Hutchinson-Gilford progeria syndrome<\/a><\/h5>\n

McCord RP, Nazario-Toole A, Zhang H, et al. Genome Res<\/em>. 2013;23(2):260-269. doi:10.1101\/gr.138032.112<\/p>\n

Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence<\/a><\/h5>\n

Swanson EC, Manning B, Zhang H, Lawrence JB. J Cell Biol<\/em>. 2013;203(6):929-942. doi:10.1083\/jcb.201306073<\/p>\n

An inhibitory role of progerin in the gene induction network of adipocyte differentiation from iPS cells<\/a><\/h5>\n

Xiong ZM, LaDana C, Wu D, Cao K. Aging (Albany NY)<\/em>. 2013;5(4):288-303. doi:10.18632\/aging.100550<\/p>\n

\n

2012<\/strong><\/p>\n

Automated image analysis of nuclear shape: what can we learn from a prematurely aged cell?<\/a><\/h5>\n

Driscoll MK, Albanese JL, Xiong ZM, Mailman M, Losert W, Cao K.\u00a0Aging (Albany NY)<\/em>. 2012;4(2):119-132. doi:10.18632\/aging.100434<\/p>\n

Progeria: translational insights from cell biology<\/a><\/h5>\n

Gordon LB, Cao K, Collins FS. J Cell Biol<\/em>. 2012;199(1):9-13. doi:10.1083\/jcb.201207072<\/p>\n

A proteomic study of Hutchinson-Gilford progeria syndrome: Application of 2D-chromotography in a premature aging disease<\/a><\/h5>\n

Wang L, Yang W, Ju W, et al. Biochem Biophys Res Commun<\/em>. 2012;417(4):1119-1126. doi:10.1016\/j.bbrc.2011.12.056<\/p>\n

Na\u00efve adult stem cells from patients with Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo<\/a><\/h5>\n

Wenzel V, Roedl D, Gabriel D, et al. Biol Open<\/em>. 2012;1(6):516-526. doi:10.1242\/bio.20121149<\/p>\n

\n

2011<\/strong><\/p>\n

Comparison of constitutional and replication stress-induced genome structural variation by SNP array and mate-pair sequencing<\/a><\/h5>\n

Arlt MF, Ozdemir AC, Birkeland SR, Lyons RH Jr, Glover TW, Wilson TE. Genetics<\/em>. 2011;187(3):675-683. doi:10.1534\/genetics.110.124776<\/p>\n

Hydroxyurea induces de novo copy number variants in human cells<\/a><\/h5>\n

Arlt MF, Ozdemir AC, Birkeland SR, Wilson TE, Glover TW. Proc Natl Acad Sci U S A<\/em>. 2011;108(42):17360-17365. doi:10.1073\/pnas.1109272108<\/p>\n

Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts<\/a><\/h5>\n

Cao K, Blair CD, Faddah DA, et al. J Clin Invest<\/em>. 2011;121(7):2833-2844. doi:10.1172\/JCI43578<\/p>\n

Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells<\/a><\/h5>\n

Cao K, Graziotto JJ, Blair CD, et al. Sci Transl Med<\/em>. 2011;3(89):89ra58. doi:10.1126\/scitranslmed.3002346<\/p>\n

Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders<\/a><\/h5>\n

Choi S, Wang W, Ribeiro AJ, et al. Nucleus<\/em>. 2011;2(6):570-579. doi:10.4161\/nucl.2.6.17798<\/p>\n

CTP: phosphocholine cytidylyltransferase \u03b1 (CCT\u03b1) and lamins alter nuclear membrane structure without affecting phosphatidylcholine synthesis<\/a><\/h5>\n

Gehrig K, Ridgway ND. Biochim Biophys Acta<\/em>. 2011;1811(6):377-385. doi:10.1016\/j.bbalip.2011.04.001<\/p>\n

Age-dependent loss of MMP-3 in Hutchinson-Gilford progeria syndrome<\/a><\/h5>\n

Harten IA, Zahr RS, Lemire JM, et al. J Gerontol A Biol Sci Med Sci<\/em>. 2011;66(11):1201-1207. doi:10.1093\/gerona\/glr137<\/p>\n

Low and high expressing alleles of the LMNA gene: implications for laminopathy disease development<\/a><\/h5>\n

Rodr\u00edguez S, Eriksson M. PLoS One<\/em>. 2011;6(9):e25472. doi:10.1371\/journal.pone.0025472<\/p>\n

Stem cell depletion in Hutchinson-Gilford progeria syndrome<\/a><\/h5>\n

Rosengardten Y, McKenna T, Grochov\u00e1 D, Eriksson M. Aging Cell<\/em>. 2011;10(6):1011-1020. doi:10.1111\/j.1474-9726.2011.00743.x<\/strong><\/p>\n

\n

2010<\/strong><\/p>\n

Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition<\/a><\/h5>\n

Marji J, O’Donoghue SI, McClintock D, et al. PLoS One<\/em>. 2010;5(6):e11132. Published 2010 Jun 15. doi:10.1371\/journal.pone.0011132<\/p>\n

Cardiovascular pathology in Hutchinson-Gilford progeria: correlation with the vascular pathology of aging<\/a><\/h5>\n

Olive M, Harten I, Mitchell R, et al. Arterioscler Thromb Vasc Biol<\/em>. 2010;30(11):2301-2309. doi:10.1161\/ATVBAHA.110.209460<\/p>\n

Effect of progerin on the accumulation of oxidized proteins in fibroblasts from Hutchinson Gilford progeria patients<\/a><\/h5>\n

Viteri G, Chung YW, Stadtman ER. Mech Ageing Dev<\/em>. 2010;131(1):2-8. doi:10.1016\/j.mad.2009.11.006<\/p>\n

\n

2009<\/strong><\/p>\n

Replication stress induces genome-wide copy number changes in human cells that resemble polymorphic and pathogenic variants<\/a><\/h5>\n

Arlt MF, Mulle JG, Schaibley VM, et al.\u00a0Am J Hum Genet<\/em>. 2009;84(3):339-350. doi:10.1016\/j.ajhg.2009.01.024<\/p>\n

Ageing-related chromatin defects through loss of the NURD complex<\/a><\/h5>\n

Pegoraro G, Kubben N, Wickert U, G\u00f6hler H, Hoffmann K, Misteli T. Nat Cell Biol<\/em>. 2009;11(10):1261-1267. doi:10.1038\/ncb1971<\/strong><\/p>\n

\n

2008<\/strong><\/p>\n

Perturbation of wild-type lamin A metabolism results in a progeroid phenotype<\/a><\/h5>\n

Candelario J, Sudhakar S, Navarro S, Reddy S, Comai L. Aging Cell<\/em>. 2008;7(3):355-367. doi:10.1111\/j.1474-9726.2008.00393.x<\/p>\n

Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing<\/a><\/h5>\n

Scaffidi P, Misteli T. Nat Cell Biol<\/em>. 2008;10(4):452-459. doi:10.1038\/ncb1708<\/p>\n

Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: effects of farnesyltransferase inhibitors<\/a><\/h5>\n

Verstraeten VL, Ji JY, Cummings KS, Lee RT, Lammerding J. Aging Cell<\/em>. 2008;7(3):383-393. doi:10.1111\/j.1474-9726.2008.00382.x<\/p>\n

\n

2007<\/strong><\/p>\n

A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells<\/a><\/h5>\n

Cao K, Capell BC, Erdos MR, Djabali K, Collins FS. Proc Natl Acad Sci U S A<\/em>. 2007;104(12):4949-4954. doi:10.1073\/pnas.0611640104<\/p>\n

Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging<\/a><\/h5>\n

Dechat T, Shimi T, Adam SA, et al. Proc Natl Acad Sci U S A<\/em>. 2007;104(12):4955-4960. doi:10.1073\/pnas.0700854104<\/p>\n

Prelamin A processing and heterochromatin dynamics in laminopathies<\/a><\/h5>\n

Maraldi NM, Mattioli E, Lattanzi G, et al. Adv Enzyme Regul<\/em>. 2007;47:154-167. doi:10.1016\/j.advenzreg.2006.12.016<\/p>\n

The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin<\/a><\/h5>\n

McClintock D, Ratner D, Lokuge M, et al. PLoS One<\/em>. 2007;2(12):e1269. Published 2007 Dec 5. doi:10.1371\/journal.pone.0001269<\/p>\n

Increased progerin expression associated with unusual LMNA mutations causes severe progeroid syndromes<\/a><\/h5>\n

Moulson CL, Fong LG, Gardner JM, et al. Hum Mutat<\/em>. 2007;28(9):882-889. doi:10.1002\/humu.20536<\/p>\n

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2006<\/strong><\/p>\n

Aggrecan expression is substantially and abnormally upregulated in Hutchinson-Gilford Progeria Syndrome dermal fibroblasts<\/a><\/h5>\n

Lemire JM, Patis C, Gordon LB, Sandy JD, Toole BP, Weiss AS. Mech Ageing Dev<\/em>. 2006;127(8):660-669. doi:10.1016\/j.mad.2006.03.004<\/p>\n

Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody<\/a><\/h5>\n

McClintock D, Gordon LB, Djabali K. Proc Natl Acad Sci U S A<\/em>. 2006;103(7):2154-2159. doi:10.1073\/pnas.0511133103<\/strong><\/p>\n

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2005<\/strong><\/p>\n

Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment<\/a><\/h5>\n

Columbaro M, Capanni C, Mattioli E, et al. Cell Mol Life Sci<\/em>. 2005;62(22):2669-2678. doi:10.1007\/s00018-005-5318-6<\/p>\n

Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition<\/a><\/h5>\n

Glynn MW, Glover TW. Hum Mol Genet<\/em>. 2005;14(20):2959-2969. doi:10.1093\/hmg\/ddi326<\/p>\n

Genomic instability in laminopathy-based premature aging<\/a><\/h5>\n

Liu B, Wang J, Chan KM, et al. Nat Med<\/em>. 2005;11(7):780-785. doi:10.1038\/nm1266<\/p>\n

Novel progerin-interactive partner proteins hnRNP E1, EGF, Mel 18, and UBC9 interact with lamin A\/C<\/a><\/h5>\n

Zhong N, Radu G, Ju W, Brown WT. Biochem Biophys Res Commun<\/em>. 2005;338(2):855-861. doi:10.1016\/j.bbrc.2005.10.020<\/p>\n

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2004<\/strong><\/p>\n

Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome<\/a><\/h5>\n

Goldman RD, Shumaker DK, Erdos MR, et al. Proc Natl Acad Sci U S A<\/em>. 2004;101(24):8963-8968. doi:10.1073\/pnas.0402943101<\/strong><\/p>\n

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2003<\/strong><\/p>\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome<\/a><\/h5>\n

Eriksson M, Brown WT, Gordon LB, et al. Nature<\/em>. 2003;423(6937):293-298. doi:10.1038\/nature01629<\/p>\n