{"id":768,"date":"2017-02-25T22:25:44","date_gmt":"2017-02-25T22:25:44","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?page_id=768"},"modified":"2023-09-22T10:25:27","modified_gmt":"2023-09-22T14:25:27","slug":"the-science-behind-progeria","status":"publish","type":"page","link":"https:\/\/www.progeriaresearch.org\/ps\/the-science-behind-progeria\/","title":{"rendered":"\u062f \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0634\u0627\u062a\u0647 \u0633\u0627\u06cc\u0646\u0633"},"content":{"rendered":"

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\n[\/et_pb_sidebar][\/et_pb_column][et_pb_column type=”3_4″ specialty_columns=”3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_row_inner custom_padding_last_edited=”on|phone” _builder_version=”4.16″ custom_padding=”39.4375px|35px|35px||false|false” custom_padding_tablet=”|35px||35px||true” custom_padding_phone=”” animation_direction=”top” global_colors_info=”{}”][et_pb_column_inner saved_specialty_column_type=”3_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.17.6″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

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\u06a9\u0644\u06cc\u06a9 \u0648\u06a9\u0693\u0626 \u062f\u0644\u062a\u0647<\/a> \u062f \u0645\u0627\u0644\u06cc\u06a9\u0648\u0644\u0631 \u06a9\u0686\u06d0 \u0685\u062e\u0647 \u062f \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0644\u0627\u0645\u0644 \u067e\u0647 \u0627\u0693\u0647 \u0646\u0648\u0631 \u0645\u0639\u0644\u0648\u0645\u0627\u062a \u062a\u0631\u0644\u0627\u0633\u0647 \u06a9\u0648\u0644\u0648 \u0644\u067e\u0627\u0631\u0647 \u062f \u0633\u0627\u0645 \u067e\u0647 \u0648\u06cc\u0646\u0627 \u0698\u0648\u0646\u062f<\/a><\/em>\u060c \u062f PRF \u062f \u0637\u0628\u064a \u0631\u06cc\u06cc\u0633 \u0689\u0627\u06a9\u067c\u0631 \u0644\u06cc\u0633\u0644\u064a \u06ab\u0648\u0631\u0689\u0646 \u0644\u062e\u0648\u0627 \u0631\u0648\u0627\u06cc\u062a \u0634\u0648\u06cc.<\/p>\n

\u062f custom_margin="-2px||||||" custom_padding=\u201d0|0px|0|0px|false|false\u201d z_index_tablet=\u201d500\u2033 Border_width_top=\u201d12px\u201d border_color_top=\u201d#00b2e2\u2033 global_module=\u201d133\u2033 locked=\u201doff\u201d global_colors_p=\u201d[et_colors_info] column_structure=\u201d1_4,1_4,1_2\u2033 make_equal=\u201don\u201dmodule_class=\u201det_pb_row_fullwidth\u201d _builder_version=\u201d4.16\u2033 \u0637\u0648\u0644=\u201d89%\u201d width_tablet=\u201d80%\u201d\u201d width_table=\u201d80%\u201d\u201d\u062f _\u0689\u06d0\u067c \u0641\u0648\u0646 =\u201d\u062f_\u0689\u06d0\u0689\u067c \u067e\u0647 \u0633\u0631 max_width=\u201d89%\u201d max_width_tablet=\u201d80%\u201d max_width_phone=\u201d\u201dmax_width_last_edited=\u201don|desktop\u201d z_index_tablet=\u201d500\u2033 make_fullwidth=\u201d\u067e\u0647\u201d \u067e\u0631\u0627\u062e\u0648\u0627\u0644\u064a_unit=\u201d01Tp_1\u201d% 100 \u0628\u0646\u062f\u201d \u067e\u0647 \u0627\u0646\u062f\u0627\u0632\u0647 Global_colors_info=\u201d{}\u201d][et_pb_column type=\u201d1_4\u2033 _builder_version=\u201d4.16\u2033 custom_padding=\u201d|||\u201d global_colors_info="{}" custom_padding__hover="|||"][et_pb_cta button_url="https:\/\/www.progeriaresearch.org\/newsletter-signup\/" button_text="\u0627\u0648\u0633 \u0646\u0648\u0645 \u0644\u06cc\u06a9\u0646\u0647 \u0648\u06a9\u0693\u0626" admin_label="\u062f \u062e\u0628\u0631 \u067e\u0627\u06bc\u064a \u0644\u067e\u0627\u0631\u0647 \u0644\u0627\u0633\u0644\u06cc\u06a9 \u0648\u06a9\u0693\u0626" \u0645\u0627\u0689\u0644_\u06a9\u0644\u0627\u0633 ="sign-btn" _builder_version="4.16\u2033 header_font_size=\u201d25px\u201d background_color=\u201d#29327a\u201d animation_style=\u201dslide\u201d animation_direction=\u201dleft\u201d animation_intensity_slide=\u201d25%\u201d header_font_size_tablet=\u201d\u201d header_font_size_phone=\u201d30p header_font_size_last_edited=\u201don|desktop\u201d z_index_tablet=\u201d500\u2033 Border_radii=\u201don|25px|25px|25px|25px\u201d Global_colors_info=\u201d{}\u201d button_bg_color__hover_enabled=\u201don\u201dcolor_tverg=\u201dtp__tverg1\u201don\u201d. button_border_color__hover_enabled="on"]<\/p>\n

\u06ab\u0689\u0648\u0646 \u06a9\u0648\u0644<\/h2>\n

\u0632\u0645\u0648\u0696 \u0644\u067e\u0627\u0631\u0647<\/h2>\n

\u062e\u0628\u0631\u067e\u0627\u06bc\u0647!<\/h2>\n

[\/et_pb_cta][\/et_pb_column][et_pb_column type=\u201d1_4\u2033 _builder_version=\u201d4.16\u2033 custom_padding=\u201d|||\u201d global_colors_info="{}" custom_padding__hover="|||"][et_pb_cta button_url="https:\/\/progeriaresearch.donorsupport.co\/-\/XZHJVWZR" button_text="\u0627\u0648\u0633 \u0645\u0631\u0633\u062a\u0647 \u0648\u06a9\u0693\u0626" admin_label="\u067e\u0647 \u06ab\u0689\u0647\u060c \u0645\u0648\u0696 \u0628\u0647 \u062f\u0631\u0645\u0644\u0646\u0647 \u0648\u0645\u0648\u0645\u0626! \u00bb module_class = "sign-btn" _builder_version="4.16" header_font_size="25px" background_color="#29327a" animation_style="slide" animation_direction="left" animation_intensity_slide="T_font_slide="T_font_size="251 \u067c\u0627\u0628\u0644\u06cc\u067c header_font_size_phone="30px" header_font_size_last_edited="on|desktop" body_font_size_tablet="" body_font_size_phone="" body_font_size_last_edited="on|desktop" z_index_tablet="500\u2033 border_radii=\u201don|25px|25px|25px|25px\u201d global_colors_info=\u201d{}\u201d button_bg_color__hover_enabled=\u201don\u201d button_bg_color__hover=\u201d#8fd2ed\u201d button_border_color__hover_enabled=\u201d]<\/p>\n

\u067e\u0647 \u06ab\u0689\u0647\u060c \u0645\u0648\u0696<\/h2>\n

\u0628\u0647<\/em><\/h2>\n

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[\/et_pb_cta][\/et_pb_column][et_pb_column \u0689\u0648\u0644=\u201d1_2\u2033 _\u062c\u0648\u0693\u0648\u0646\u06a9\u06cc_\u0646\u0633\u062e\u0647=\u201d4.16\u2033 \u062f\u0648\u062f\u06cc\u0632_\u067e\u06cc\u0689\u06cc\u0646\u06ab=\u201d||\u201d global_colors_info=\u201d{}\u201d custom_padding__hover=\u201d||\u201d][et_pb_image src=\u201dhttps:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2023\/06\/2023-footer-strip-5.png\u201d title_text=\u201d2023 \u0641\u0648\u067c\u0631 \u067e\u067c\u0647 5\u2033 _builder_version=\u201d4.21.0\u2033 _module_preset=\u201ddefault\u201d custom_margin=\u201d35px|||false|false\u201d global_colors_info=\u201d{}\u201d][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” disabled_on=”off|off|off” _builder_version=”4.16″ border_width_bottom=”55px” border_color_bottom=”#29327a” global_colors_info=”{}”][et_pb_fullwidth_header _builder_version=”4.16″ title_font_size=”55″ background_color=”#29327a” background_image=”https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/About-Header.jpg” background_position=”center_left” custom_padding=”9vw||9vw||true” custom_padding_tablet=”” custom_padding_phone=”|56px||” custom_padding_last_edited=”on|desktop” title_font_size_tablet=”45px” title_font_size_phone=”40px” title_font_size_last_edited=”on|phone” z_index_tablet=”500″ custom_css_main_element=”background-position: center 18% !important;” global_colors_info=”{}”] The Science Behind Progeria [\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ use_custom_gutter=”on” gutter_width=”1″ specialty=”on” padding_left_1=”35px” padding_left_2=”35px” padding_2_tablet=”|||0px” padding_2_phone=”|||0px” padding_2_last_edited=”on|desktop” module_class_1=”sidebar-secondary-nav” module_class=”handprint-bg” _builder_version=”4.16″ background_image=”https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/blue-handprint-only.png” parallax=”on” parallax_method=”off” inner_width=”100%” inner_max_width=”100%” custom_padding=”0|0px|54px|0px|false|false” z_index_tablet=”500″ border_width_top=”10px” border_color_top=”#8fd2ed” use_custom_width=”on” width_unit=”off” custom_width_percent=”100%” […]<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"\t\t\t\t[vc_row][vc_column][vc_custom_heading source=\"post_title\" font_container=\"tag:h1|text_align:center\" use_theme_fonts=\"yes\"][vc_column_text]\"\"Children with Progeria are genetically predisposed to premature, progressive heart disease. Death occurs almost exclusively due to widespread heart disease, the leading cause of death worldwide. As with any person suffering from heart disease, the common events for Progeria children are high blood pressure, strokes, angina (chest pain due to poor blood flow to the heart itself), enlarged heart, and heart failure, all conditions associated with aging.\r\n\r\nThus, there is clearly a tremendous need for research in Progeria. Finding a cure for Progeria will not only help these children, but may provide keys for treating millions of adults with heart disease and stroke associated with the natural aging process.\r\n\r\nHutchinson-Gilford Progeria Syndrome (\"Progeria\", or \"HGPS\") is caused by a mutation in the gene called LMNA (pronounced, lamin - a). The LMNA gene produces the Lamin A protein, which is the structural scaffolding that holds the nucleus of a cell together. Researchers now believe that the defective Lamin A protein makes the nucleus unstable. That cellular instability appears to lead to the process of premature aging in Progeria.\r\n\r\nPRF was the driving force behind finding the gene responsible for Progeria. A group of leading scientists from The Progeria Research Foundation's Genetics Consortium was able to isolate the Progeria gene in October 2002, and in April 2003, PRF led the announcement that Progeria is caused by a mutation of the gene LMNA, or Lamin A. This gene discovery was reported in the leading scientific journal Nature\u00a8.\r\n\r\nThe Progeria gene finding involved intensive collaboration between scientists including Dr. Leslie Gordon, PRF's Medical Director, Dr. W. Ted Brown, a world expert on Progeria and Chairman of New York's Institute of Basic Research in Developmental Disabilities' Department of Human Genetics, Dr. Tom Glover, a PRF grantee and Professor at University of Michigan's Department of Human Genetics, Dr. Francis Collins, Director of the National Human Genome Research Institute (responsible for mapping the human genome) and the senior author on the report, and first author Dr. Maria Eriksson, a postdoctoral fellow with Dr. Collins.\r\n

How is Progeria Diagnosed?<\/h1>\r\nNow that the gene mutation has been identified, The Progeria Research Foundation has created a Diagnostics Testing Program<\/a><\/strong>. We can now look at the specific genetic change, or mutation, in the Progeria gene that leads to HGPS. After an initial clinical evaluation (looking at the child's appearance and medical records), a sample of the child's blood will be tested for the Progeria gene. For the first time ever, there is a definitive, scientific way to diagnose the children. This will lead to more accurate and earlier diagnoses so that the children can receive proper care.[\/vc_column_text][\/vc_column][\/vc_row]\t\t","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-768","page","type-page","status-publish","hentry"],"yoast_head":"\nscience behind Progeria | The Progeria Research Foundation<\/title>\n<meta name=\"description\" content=\"The Science Behind Progeria have shown that children with Progeria are genetically predisposed to premature, progressive heart disease.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.progeriaresearch.org\/ps\/the-science-behind-progeria\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"science behind Progeria | The Progeria Research Foundation\" \/>\n<meta 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