{"id":788,"date":"2017-02-26T18:53:03","date_gmt":"2017-02-26T18:53:03","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?page_id=788"},"modified":"2023-09-21T12:51:17","modified_gmt":"2023-09-21T16:51:17","slug":"medical-database","status":"publish","type":"page","link":"https:\/\/www.progeriaresearch.org\/ps\/medical-database\/","title":{"rendered":"\u0637\u0628\u064a \u0689\u06cc\u067c\u0627\u0628\u06cc\u0633"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; disabled_on=&#8221;off|off|off&#8221; _builder_version=&#8221;4.16&#8243; border_width_bottom=&#8221;55px&#8221; border_color_bottom=&#8221;#29327a&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_fullwidth_header _builder_version=&#8221;4.16&#8243; title_font=&#8221;||||||||&#8221; title_font_size=&#8221;55&#8243; background_color=&#8221;#29327a&#8221; background_image=&#8221;https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2020\/12\/Jes.jpg&#8221; background_position=&#8221;center_left&#8221; custom_padding=&#8221;11.5vw||11.5vw||true&#8221; custom_padding_tablet=&#8221;&#8221; custom_padding_phone=&#8221;|56px||&#8221; custom_padding_last_edited=&#8221;on|desktop&#8221; title_font_size_tablet=&#8221;45px&#8221; title_font_size_phone=&#8221;40px&#8221; title_font_size_last_edited=&#8221;on|phone&#8221; z_index_tablet=&#8221;500&#8243; custom_css_main_element=&#8221;background-position: center 18% !important;&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h1 class=\"vc_custom_heading\" data-fontsize=\"34\" data-lineheight=\"48\">\u0637\u0628\u064a <br \/>\u0689\u06cc\u067c\u0627\u0628\u06cc\u0633<\/h1>\n<p>[\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;1&#8243; specialty=&#8221;on&#8221; padding_left_1=&#8221;35px&#8221; padding_left_2=&#8221;35px&#8221; padding_2_tablet=&#8221;|||0px&#8221; padding_2_phone=&#8221;|||0px&#8221; padding_2_last_edited=&#8221;on|desktop&#8221; module_class_1=&#8221;sidebar-secondary-nav&#8221; module_class=&#8221;handprint-bg&#8221; _builder_version=&#8221;4.16&#8243; background_image=&#8221;https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/blue-handprint-only.png&#8221; parallax=&#8221;on&#8221; parallax_method=&#8221;off&#8221; inner_width=&#8221;100%&#8221; inner_max_width=&#8221;100%&#8221; custom_padding=&#8221;0|0px|54px|0px|false|false&#8221; z_index_tablet=&#8221;500&#8243; border_width_top=&#8221;10px&#8221; border_color_top=&#8221;#8fd2ed&#8221; use_custom_width=&#8221;on&#8221; width_unit=&#8221;off&#8221; custom_width_percent=&#8221;100%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_sidebar area=&#8221;et_pb_widget_area_1&#8243; disabled_on=&#8221;on|on|off&#8221; module_class=&#8221;subpage-sidebars&#8221; _builder_version=&#8221;4.16&#8243; animation_style=&#8221;fade&#8221; z_index_tablet=&#8221;500&#8243; border_width_right=&#8221;5px&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<br \/>\n[\/et_pb_sidebar][\/et_pb_column][et_pb_column type=&#8221;3_4&#8243; specialty_columns=&#8221;3&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_row_inner _builder_version=&#8221;4.16&#8243; background_color=&#8221;#00b2e2&#8243; custom_margin=&#8221;41px||&#8221; custom_margin_tablet=&#8221;0px||&#8221; custom_margin_phone=&#8221;&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; custom_padding=&#8221;39.4375px|20px|0|20px|false|true&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;top&#8221; animation_intensity_slide=&#8221;25%&#8221; box_shadow_style=&#8221;preset1&#8243; box_shadow_blur=&#8221;38px&#8221; box_shadow_spread=&#8221;-12px&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column_inner saved_specialty_column_type=&#8221;3_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;What is the International Medical and Research Database?&#8221; _builder_version=&#8221;4.16&#8243; header_2_line_height=&#8221;1.2em&#8221; background_layout=&#8221;dark&#8221; custom_margin=&#8221;||35px&#8221; custom_padding=&#8221;|||&#8221; custom_padding_tablet=&#8221;|50px||50px||true&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|desktop&#8221; header_font_size_tablet=&#8221;&#8221; header_font_size_phone=&#8221;&#8221; header_font_size_last_edited=&#8221;on|desktop&#8221; header_2_font_size_tablet=&#8221;25px&#8221; header_2_font_size_phone=&#8221;&#8221; header_2_font_size_last_edited=&#8221;on|tablet&#8221; header_4_font_size_tablet=&#8221;&#8221; header_4_font_size_phone=&#8221;19px&#8221; header_4_font_size_last_edited=&#8221;on|phone&#8221; header_4_line_height_tablet=&#8221;&#8221; header_4_line_height_phone=&#8221;1.2em&#8221; header_4_line_height_last_edited=&#8221;on|phone&#8221; z_index_tablet=&#8221;500&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2 style=\"text-align: center;\"><strong>\u062f \u0646\u0693\u06cc\u0648\u0627\u0644 \u0637\u0628\u064a \u0627\u0648 \u0685\u06cc\u0693\u0646\u06d0 \u0689\u06cc\u067c\u0627\u0628\u06cc\u0633 \u0685\u0647 \u0634\u06cc \u062f\u06cc\u061f<\/strong><\/h2>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner custom_padding_last_edited=&#8221;on|phone&#8221; _builder_version=&#8221;4.16&#8243; custom_margin=&#8221;||20px&#8221; custom_padding=&#8221;|35px|0|0px|false|false&#8221; custom_padding_tablet=&#8221;|35px||35px||true&#8221; custom_padding_phone=&#8221;&#8221; animation_direction=&#8221;top&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column_inner saved_specialty_column_type=&#8221;3_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.17.4&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>\u0645\u0648\u0696 \u0644\u0647 \u067c\u0648\u0644\u06d0 \u0646\u0693\u06cd \u0685\u062e\u0647 \u062f \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0645\u0627\u0634\u0648\u0645\u0627\u0646\u0648 \u0644\u067e\u0627\u0631\u0647 \u0637\u0628\u064a \u0631\u06cc\u06a9\u0627\u0631\u0689\u0648\u0646\u0647 \u0631\u0627\u067c\u0648\u0644\u0648\u0648. \u0628\u06cc\u0627 \u0645\u0648\u0696 \u062f \u0637\u0628\u064a \u067e\u0627\u0645\u0644\u0631\u0646\u06d0 \u0647\u0631 \u0627\u0693\u062e \u062a\u0647 \u06ab\u0648\u0631\u0648 \u0686\u06d0 \u0645\u0627\u0634\u0648\u0645\u0627\u0646\u0648 \u062a\u0647 \u0648\u0631\u06a9\u0693\u0644 \u0634\u0648\u064a. \u0645\u0648\u0696 \u0627\u062d\u0635\u0627\u06cc\u0648\u064a \u062a\u062d\u0644\u06cc\u0644\u0648\u0646\u0647 \u062a\u0631\u0633\u0631\u0647 \u06a9\u0648\u0648\u060c \u0627\u0648 \u06ab\u0648\u0631\u0648 \u0686\u06d0 \u06a9\u0648\u0645 \u062f\u0631\u0645\u0644\u0646\u06d0 \u062f \u0698\u0648\u0646\u062f \u06a9\u06cc\u0641\u06cc\u062a \u0633\u0627\u062a\u0644\u0648 \u0644\u067e\u0627\u0631\u0647 \u06a9\u0627\u0631 \u06a9\u0693\u06cc \u0627\u0648 \u06a9\u0648\u0645 \u062f\u0631\u0645\u0644\u0646\u06d0 \u06a9\u0627\u0631 \u0646\u0647 \u062f\u06cc \u06a9\u0693\u06cc. \u0689\u06cc\u0631\u06cc \u0689\u0627\u06a9\u067c\u0631\u0627\u0646\u0648 \u06cc\u0648\u0627\u0632\u06d0 \u06cc\u0648 \u0645\u0627\u0634\u0648\u0645 \u062f \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0631\u0647 \u0644\u06cc\u062f\u0644\u06cc \u060c \u0627\u0648 \u062f\u0648\u06cc \u0689\u0627\u0689\u0647 \u0646\u062f\u064a \u0686\u06d0 \u0685\u0647 \u0648\u06a9\u0693\u064a \u06a9\u0644\u0647 \u0686\u06d0 \u0645\u0627\u0634\u0648\u0645 \u062f \u0632\u0693\u0647 \u062f\u0631\u0645\u0644\u0648 \u060c \u0627\u0646\u0633\u062a\u06cc\u0632\u06cc\u0627 \u060c \u0627\u0648 \u0645\u0646\u0627\u0633\u0628 \u0641\u0632\u06cc\u06a9\u064a \u062f\u0631\u0645\u0644\u0646\u06d0 \u062a\u0647 \u0627\u0693\u062a\u06cc\u0627 \u0648\u0644\u0631\u064a. \u0645\u0648\u0696 \u062f \u062f\u06d0 \u0689\u06cc\u067c\u0627\u0628\u06cc\u0633 \u067e\u0631\u0648\u06ab\u0631\u0627\u0645 \u067e\u0631 \u0628\u0646\u0633\u067c \u0689\u0627\u06a9\u067c\u0631\u0627\u0646\u0648 \u0627\u0648 \u062f \u0647\u063a\u0648\u06cc \u06a9\u0648\u0631\u0646\u06cc\u0648 \u062a\u0647 \u062f \u0645\u0634\u0648\u0631\u06d0 \u0648\u0631\u06a9\u0648\u0644\u0648 \u0648\u0693\u062a\u06cc\u0627 \u0644\u0631\u0648.<\/p>\n<p>\u062f \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0685\u06cc\u0693\u0646\u06cc\u0632 \u0628\u0646\u0633\u067c \u062f \u062f\u06d0 \u067e\u0647 \u0632\u0693\u0647 \u067e\u0648\u0631\u06d0 \u067e\u0631\u0648\u0698\u06d0 \u0644\u067e\u0627\u0631\u0647 \u062f \u06ab\u06cc\u0631\u0648\u0646\u067c\u0648\u0644\u0648\u0698\u064a \u0627\u0648 \u0631\u0648\u063a\u062a\u06cc\u0627 \u067e\u0627\u0645\u0644\u0631\u0646\u06d0 \u0685\u06cc\u0693\u0646\u06d0 \u0644\u067e\u0627\u0631\u0647 \u062f \u0628\u0631\u0627\u0648\u0646 \u067e\u0648\u0647\u0646\u062a\u0648\u0646 \u0645\u0631\u06a9\u0632 \u0633\u0631\u0647 \u0647\u0645\u06a9\u0627\u0631\u064a \u06a9\u0648\u064a. \u062f \u0628\u0631\u0627\u0648\u0646 \u0645\u0631\u06a9\u0632 \u062f \u0631\u0648\u063a\u062a\u06cc\u0627 \u067e\u0627\u0645\u0644\u0631\u0646\u06d0 \u0689\u06cc\u067c\u0627\u0628\u06cc\u0633\u0648\u0646\u0648 \u0631\u0627\u0645\u06cc\u0646\u0681\u062a\u0647 \u06a9\u0648\u0644\u0648 \u0627\u0648 \u062a\u062d\u0644\u06cc\u0644 \u06a9\u0648\u0644\u0648 \u0633\u0631\u0647 \u0689\u06cc\u0631\u06cc \u06a9\u0644\u0648\u0646\u0647 \u062a\u062c\u0631\u0628\u0647 \u0644\u0631\u064a.<\/p>\n<p>\u0645\u0648\u0696 \u067e\u0647 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u06a9\u06d0 \u062f \u0646\u0627\u0631\u0648\u063a\u06cd \u0627\u0633\u0627\u0633 \u067e\u0647 \u0627\u0693\u0647 \u0646\u0648\u0631 \u067e\u0648\u0647\u06cc\u062f\u0648 \u0644\u067e\u0627\u0631\u0647 \u0637\u0628\u064a \u0631\u06cc\u06a9\u0627\u0631\u0689\u0648\u0646\u0647 \u0647\u0645 \u06a9\u0627\u0631\u0648\u0648 \u060c \u06a9\u0648\u0645 \u0686\u06d0 \u067e\u0647 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u06a9\u06d0 \u062f \u0646\u0648\u064a \u0685\u06cc\u0693\u0646\u06d0 \u0644\u067e\u0627\u0631\u0647 \u062f \u067e\u0633\u0631\u0644\u064a \u067e\u0647 \u062a\u0648\u06ab\u0647 \u06a9\u0627\u0631 \u06a9\u0648\u064a \u0627\u0648 \u062f \u0632\u0693\u0648 \u0646\u0627\u0631\u0648\u063a\u06cc\u0648 \u0644\u06a9\u0647 \u062f \u0632\u0693\u0647 \u0646\u0627\u0631\u0648\u063a\u06cd \u06a9\u06d0. \u062f\u0627 \u0645\u0645\u06a9\u0646 \u062f \u0645\u0627\u0634\u0648\u0645\u0627\u0646\u0648 \u0627\u0648 \u0632\u0645\u0648\u0696 \u067c\u0648\u0644\u0648 \u0644\u067e\u0627\u0631\u0647 \u062f \u0646\u0648\u064a \u062f\u0631\u0645\u0644\u0646\u06d0 \u0644\u067e\u0627\u0631\u0647 \u0646\u069a\u06d0 \u0631\u0627\u0645\u06cc\u0646\u0681\u062a\u0647 \u06a9\u0693\u064a!<\/p>\n<p>\u0647\u06cc\u0685\u06a9\u0644\u0647 \u062f \u0645\u0627\u0634\u0648\u0645\u062a\u0648\u0628 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0645\u0631\u06a9\u0632\u064a \u0689\u06cc\u067c\u0627\u0628\u06cc\u0633 \u0634\u062a\u0648\u0646 \u0646\u0644\u0631\u064a \u0686\u06d0 \u0644\u0647 \u0647\u063a\u06d0 \u0685\u062e\u0647 \u062f \u0631\u0648\u063a\u062a\u06cc\u0627 \u067e\u0627\u0645\u0644\u0631\u0646\u06d0 \u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0631\u0627\u0648\u0628\u0627\u0633\u064a. \u062f\u0627 \u062f \u0646\u0627\u0631\u0648\u063a\u0627\u0646\u0648 \u063a\u06cc\u0631 \u0627\u0631\u0627\u062f\u064a \u06a9\u0644\u06cc\u0646\u06cc\u06a9\u064a \u0646\u0627\u0648\u0693\u0647 \u0686\u0644\u0646\u062f \u060c \u063a\u0644\u0637 \u062a\u0634\u062e\u06cc\u0635 \u0627\u0648 \u0681\u0646\u0689\u0648\u0644 \u062a\u0634\u062e\u06cc\u0635 \u0644\u0627\u0645\u0644 \u0634\u0648\u06cc \u060c \u067e\u0647 \u0633\u0627\u062f\u0647 \u0689\u0648\u0644 \u0681\u06a9\u0647 \u0686\u06d0 \u0633\u0627\u062a\u0648\u0646\u06a9\u064a \u0646\u0647 \u067e\u0648\u0647\u06cc\u0696\u064a \u0686\u06d0 \u06a9\u0648\u0645\u06d0 \u0637\u0628\u064a \u0633\u062a\u0631\u0627\u062a\u06cc\u0698\u06cd \u062f \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0646\u0648\u0631\u0648 \u0645\u0627\u0634\u0648\u0645\u0627\u0646\u0648 \u0633\u0631\u0647 \u0628\u0631\u06cc\u0627\u0644\u06cd \u0648\u06d0 \u0627\u0648 \u06a9\u0648\u0645\u06d0 \u0646\u062f\u064a. \u062f \u062f\u06d0 \u067e\u0631\u0648\u0698\u06d0 \u0647\u062f\u0641 \u062f \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0631\u0647 \u062f \u0645\u0627\u0634\u0648\u0645\u0627\u0646\u0648 \u0644\u067e\u0627\u0631\u0647 \u062f \u0631\u0648\u063a\u062a\u06cc\u0627 \u067e\u0627\u0645\u0644\u0631\u0646\u06d0 \u0631\u06cc\u06a9\u0627\u0631\u0689\u0648\u0646\u0647 \u0631\u0627\u067c\u0648\u0644\u0648\u0644 \u0627\u0648 \u062f \u0631\u0648\u063a\u062a\u06cc\u0627 \u067e\u0627\u0645\u0644\u0631\u0646\u06d0 \u0645\u062a\u062e\u0635\u0635\u06cc\u0646\u0648 \u060c \u0637\u0628\u064a \u0685\u06cc\u0693\u0648\u0646\u06a9\u0648 \u0627\u0648 \u062f \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0631\u0647 \u062f \u0645\u0627\u0634\u0648\u0645\u0627\u0646\u0648 \u06a9\u0648\u0631\u0646\u06cc\u0648 \u0644\u062e\u0648\u0627 \u06a9\u0627\u0631\u0648\u0644\u0648 \u0644\u067e\u0627\u0631\u0647 \u062f \u0645\u0631\u06a9\u0632\u064a \u0631\u0648\u063a\u062a\u06cc\u0627 \u0689\u06cc\u067c\u0627\u0628\u06cc\u0633 \u0631\u0627\u0645\u06cc\u0646\u0681\u062a\u0647 \u06a9\u0648\u0644 \u062f\u064a.<\/p>\n<h4><strong>\u062f \u0689\u06cc\u067c\u0627\u0628\u06cc\u0633 \u0645\u0648\u062e\u06d0<\/strong><\/h4>\n<ul>\n<li>\u062f \u062f\u06d0 \u0644\u067e\u0627\u0631\u0647 \u0686\u06d0 \u067e\u0647 \u062a\u0641\u0635\u06cc\u0644 \u0633\u0631\u0647 \u062a\u0634\u0631\u06cc\u062d \u06a9\u0693\u0626 \u0686\u06d0 \u062f \u062f\u0631\u0645\u0644\u0646\u06d0 \u06a9\u0648\u0645\u06d0 \u0633\u062a\u0631\u0627\u062a\u06cc\u0698\u06cd \u0628\u0631\u06cc\u0627\u0644\u06cd \u0648\u06d0\u060c \u0627\u0648 \u06a9\u0648\u0645\u06d0 \u062f\u0631\u0645\u0644\u0646\u06d0 \u062f \u0647\u063a\u0648 \u0637\u0628\u064a \u0645\u0633\u0644\u0648 \u0644\u067e\u0627\u0631\u0647 \u0646\u0627\u06a9\u0627\u0645\u06d0 \u0634\u0648\u06d0 \u0686\u06d0 \u062f HGPS \u0633\u0631\u0647 \u0645\u0627\u0634\u0648\u0645\u0627\u0646 \u0648\u0631\u0633\u0631\u0647 \u0645\u062e \u062f\u064a. \u062f\u0627 \u0645\u0645\u06a9\u0646 \u062f \u06a9\u0648\u0631\u0646\u06cc\u0648 \u0627\u0648 \u062f \u062f\u0648\u06cc \u0689\u0627\u06a9\u067c\u0631\u0627\u0646\u0648 \u0633\u0631\u0647 \u0645\u0631\u0633\u062a\u0647 \u0648\u06a9\u0693\u064a \u0686\u06d0 \u067e\u0648\u0647 \u0634\u064a \u0686\u06d0 \u0685\u0646\u06ab\u0647 \u062f \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0645\u0627\u0634\u0648\u0645\u0627\u0646\u0648 \u0644\u067e\u0627\u0631\u0647 \u063a\u0648\u0631\u0647 \u067e\u0627\u0645\u0644\u0631\u0646\u0647 \u0648\u06a9\u0693\u064a.<\/li>\n<li>\u062f \u0647\u063a\u0648 \u0645\u0633\u0644\u0648 \u067e\u0647 \u0627\u0693\u0647 \u0686\u06d0 \u062f HGPS \u0633\u0631\u0647 \u062f \u0645\u0627\u0634\u0648\u0645\u0627\u0646\u0648 \u062f \u0698\u0648\u0646\u062f \u06a9\u06cc\u0641\u06cc\u062a \u0644\u067e\u0627\u0631\u0647 \u0645\u0647\u0645 \u062f\u064a \u067e\u0647 \u063a\u06cc\u0631 \u0637\u0628\u064a \u0698\u0628\u0647 \u06a9\u06d0 \u06a9\u0648\u0631\u0646\u06cc\u0648 \u062a\u0647 \u062f \u0631\u0648\u063a\u062a\u06cc\u0627 \u067e\u0627\u0645\u0644\u0631\u0646\u06d0 \u0633\u067e\u0627\u0631\u069a\u062a\u0646\u06d0 \u0686\u0645\u062a\u0648 \u06a9\u0648\u0644.<\/li>\n<li>\u0689\u06cc\u067c\u0627\u0628\u06cc\u0633 \u062f HGPS \u0637\u0628\u06cc\u0639\u062a \u0627\u0648 \u062f \u0646\u0648\u0631\u0648 \u0646\u0627\u0631\u0648\u063a\u06cc\u0648 \u0637\u0628\u06cc\u0639\u062a \u0644\u06a9\u0647 \u0627\u06cc\u062a\u0631\u0648\u0633\u06a9\u0644\u0631\u0648\u0633\u06cc\u0633 \u067e\u0647 \u0627\u0693\u0647 \u0646\u0648\u064a \u0628\u0635\u06cc\u0631\u062a \u062a\u0631\u0644\u0627\u0633\u0647 \u06a9\u0648\u0644\u0648 \u0644\u067e\u0627\u0631\u0647 \u06cc\u0648\u0647 \u0633\u0631\u0686\u06cc\u0646\u0647 \u062f\u0647 \u060c \u06a9\u0648\u0645 \u0686\u06d0 \u067e\u0647 \u067e\u0627\u06cc\u0644\u0647 \u06a9\u06d0 \u0628\u0647 \u062f \u0646\u0648\u064a \u0685\u06cc\u0693\u0646\u06cc\u0632\u0648 \u067e\u0631\u0648\u0698\u0648 \u067e\u0631\u0645\u062e\u062a\u06ab \u0647\u0685\u0648\u064a.<\/li>\n<\/ul>\n<h4><strong>\u062f \u0627\u062f\u0627\u0631\u06cc \u0628\u06cc\u0627\u06a9\u062a\u0646\u06d0 \u0628\u0648\u0631\u0689 \u062a\u0635\u0648\u06cc\u0628\u0648\u0646\u0647:<\/strong><\/h4>\n<p>\u062f PRF \u0637\u0628\u064a \u0627\u0648 \u0685\u06cc\u0693\u0646\u06d0 \u0689\u06cc\u067c\u0627\u0628\u06cc\u0633 \u062f \u0627\u062f\u0627\u0631\u064a \u0628\u06cc\u0627\u06a9\u062a\u0646\u06d0 \u0628\u0648\u0631\u0689 (IRB) \u062f\u06cc \u0686\u06d0 \u062f \u0631\u0648\u0689 \u067c\u0627\u067e\u0648 \u0631\u0648\u063a\u062a\u0648\u0646 \u0627\u0648 \u062f \u0628\u0631\u0627\u0648\u0646 \u067e\u0648\u0647\u0646\u062a\u0648\u0646 \u06a9\u0645\u06cc\u067c\u0648 \u0644\u062e\u0648\u0627 \u062f \u0628\u0634\u0631\u064a \u0645\u0636\u0627\u0645\u06cc\u0646\u0648 \u0633\u0627\u062a\u0646\u06d0 \u067e\u0647 \u0627\u0693\u0647 \u062a\u0635\u0648\u06cc\u0628 \u0634\u0648\u06cc. \u062f \u0631\u0648\u0689 \u067c\u0627\u067e\u0648 \u0631\u0648\u063a\u062a\u0648\u0646 \u0641\u062f\u0631\u0627\u0644\u064a \u067e\u0631\u0627\u062e\u0647 \u062a\u0636\u0645\u06cc\u0646 FWA00001230\u060c \u0645\u0637\u0627\u0644\u0639\u0647 CMTT# 0152-01\u060c \u062f \u0628\u0631\u0627\u0648\u0646 \u067e\u0648\u0647\u0646\u062a\u0648\u0646 \u0641\u062f\u0631\u0627\u0644\u064a \u067e\u0631\u0627\u062e\u0647 \u062a\u0636\u0645\u06cc\u0646 FWA 00004460\u060c \u0645\u0637\u0627\u0644\u0639\u0647 CMTT# 0211991243<\/p>\n<h4 style=\"font-weight: 400;\"><strong>\u067e\u0647 \u062e\u067e\u0631\u0648\u0646\u0648 \u06a9\u06d0 \u062f \u0645\u0648\u0627\u062f\u0648 \u06a9\u0627\u0631\u0648\u0644:<\/strong><\/h4>\n<p style=\"font-weight: 400;\">\u062f \u067c\u0648\u0644\u0648 \u062e\u067e\u0631\u0648\u0646\u0648 \u0644\u067e\u0627\u0631\u0647 \u0686\u06d0 \u062f \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0631\u06cc\u0633\u0631\u0686 \u0641\u0627\u0648\u0646\u0689\u06cc\u0634\u0646 \u0637\u0628\u064a \u0627\u0648 \u0685\u06cc\u0693\u0646\u06d0 \u0689\u06cc\u067c\u0627\u0628\u06cc\u0633 \u0685\u062e\u0647 \u062a\u0631\u0644\u0627\u0633\u0647 \u0634\u0648\u064a \u0645\u0639\u0644\u0648\u0645\u0627\u062a\u0648 \u06a9\u0627\u0631\u0648\u0644\u0648 \u067e\u0627\u06cc\u0644\u0647 \u06a9\u06d0 \u060c \u0685\u06cc\u0693\u0648\u0646\u06a9\u064a \u0627\u0693\u06cc\u0646 \u062f\u064a \u0686\u06d0 \u0644\u0627\u0646\u062f\u06d0 \u0646\u0631\u062e\u0648\u0646\u0647 \u062f \u0645\u0648\u0627\u062f\u0648 \u0627\u0648 \u0645\u06cc\u062a\u0648\u062f\u0648\u0646\u0648 \u0628\u0631\u062e\u06d0 \u06a9\u06d0 \u0634\u0627\u0645\u0644 \u06a9\u0693\u064a (\u0646\u0647 \u06cc\u0648\u0627\u0632\u06d0 \u0627\u0639\u062a\u0631\u0627\u0641\u0648\u0646\u0647). \u062f\u0627 \u06a9\u0644\u0645\u06d0 \u0645\u0645\u06a9\u0646 \u06cc\u0648 \u0685\u0647 \u062a\u0648\u067e\u06cc\u0631 \u0648\u0644\u0631\u064a\u060c \u067e\u062f\u06d0 \u067e\u0648\u0631\u06d0 \u0627\u0693\u0647 \u0644\u0631\u064a \u0686\u06d0 \u06a9\u0648\u0645 \u0645\u0639\u0644\u0648\u0645\u0627\u062a \u062f \u0685\u06cc\u0693\u0646\u06d0 \u0644\u067e\u0627\u0631\u0647 \u0686\u0645\u062a\u0648 \u0634\u0648\u064a.<\/p>\n<p style=\"font-weight: 400;\">&quot;\u067e\u06cc\u0698\u0646\u062f\u0644 \u0634\u0648\u064a \u06a9\u0644\u06cc\u0646\u06cc\u06a9\u064a \u0645\u0639\u0644\u0648\u0645\u0627\u062a \u062f \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0631\u06cc\u0633\u0631\u0686 \u0641\u0627\u0624\u0646\u0688\u06cc\u0634\u0646 (PRF) \u0637\u0628\u064a \u0627\u0648 \u0685\u06cc\u0693\u0646\u06d0 \u0689\u06cc\u067c\u0627\u0628\u06cc\u0633 \u0685\u062e\u0647 \u062a\u0631\u0644\u0627\u0633\u0647 \u0634\u0648\u064a.<a href=\"https:\/\/www.progeriaresearch.org\/ps\/\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/www.progeriaresearch.org&amp;source=gmail&amp;ust=1656539975208000&amp;usg=AOvVaw2-Ugfzc0IoTq-jMG-qMW0F\">www.progeriaresearch.org<\/a>).&quot;<\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; background_color=&#8221;#29327a&#8221; custom_padding=&#8221;40px|35px|35.2344px|35px|false|true&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;right&#8221; animation_intensity_slide=&#8221;25%&#8221; border_width_bottom=&#8221;10px&#8221; border_color_bottom=&#8221;#8fd2ed&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column_inner saved_specialty_column_type=&#8221;3_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;Publications Stemming From The Progeria Research Foundation Medical and Research Database&#8221; _builder_version=&#8221;4.16&#8243; header_text_align=&#8221;center&#8221; header_text_color=&#8221;#ffffff&#8221; background_layout=&#8221;dark&#8221; animation_style=&#8221;fade&#8221; header_font_size_tablet=&#8221;&#8221; header_font_size_phone=&#8221;30px&#8221; header_font_size_last_edited=&#8221;on|desktop&#8221; z_index_tablet=&#8221;500&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2 style=\"text-align: center;\"><strong>\u062e\u067e\u0631\u0648\u0646\u06d0 \u062f \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0631\u06cc\u0633\u0631\u0686 \u0641\u0627\u0624\u0646\u0688\u06cc\u0634\u0646 \u0637\u0628\u064a \u0627\u0648 \u0685\u06cc\u0693\u0646\u06d0 \u0689\u06cc\u067c\u0627\u0628\u06cc\u0633 \u0685\u062e\u0647 \u0631\u0627\u0645\u06cc\u0646\u0681\u062a\u0647 \u06a9\u06cc\u0696\u064a<\/strong><\/h2>\n<p>\u00a0<\/p>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner column_structure=&#8221;1_2,1_2&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; padding_left_right_link_1=&#8221;false&#8221; padding_left_right_link_2=&#8221;false&#8221; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|35px|0|0px|false|false&#8221; custom_padding_tablet=&#8221;|35px||35px||true&#8221; custom_padding_phone=&#8221;&#8221; animation_direction=&#8221;top&#8221; border_width_bottom=&#8221;10px&#8221; border_color_bottom=&#8221;#8fd2ed&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column_inner type=&#8221;1_2&#8243; saved_specialty_column_type=&#8221;3_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|20px||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>\u062f \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0631\u06cc\u0633\u0631\u0686 \u0641\u0627\u0624\u0646\u0688\u06cc\u0634\u0646 \u0637\u0628\u064a \u0627\u0648 \u0685\u06cc\u0693\u0646\u06d0 \u0689\u06cc\u067c\u0627\u0628\u06cc\u0633 \u0644\u0627\u0646\u062f\u06d0 \u0637\u0628\u064a \u062e\u067e\u0631\u0648\u0646\u0648 \u06a9\u06d0 \u0645\u0631\u0633\u062a\u0647 \u06a9\u0693\u06d0:<\/p>\n<p><strong>\u062f \u06a9\u0644\u06cc\u0646\u06cc\u06a9\u064a \u067e\u0627\u0645\u0644\u0631\u0646\u06d0 \u0644\u0627\u0633\u064a \u06a9\u062a\u0627\u0628<\/strong><\/p>\n<p><em>\u062f \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0644\u0627\u0633\u064a \u06a9\u062a\u0627\u0628\u061b \u062f \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0631\u0647 \u062f \u0645\u0627\u0634\u0648\u0645\u0627\u0646\u0648 \u062f \u06a9\u0648\u0631\u0646\u06cc\u0648 \u0627\u0648 \u0631\u0648\u063a\u062a\u06cc\u0627 \u067e\u0627\u0645\u0644\u0631\u0646\u06d0 \u0686\u0645\u062a\u0648 \u06a9\u0648\u0646\u06a9\u0648 \u0644\u067e\u0627\u0631\u0647 \u0644\u0627\u0631\u069a\u0648\u062f.<\/em> \u06ab\u0648\u0631\u0689\u0646\u060c \u0644\u06cc\u0633\u0644\u064a \u0628\u06cc\u060c \u0627\u062c\u0631\u0627\u06cc\u0648\u064a \u0645\u062f\u06cc\u0631. \u062f \u06a9\u0627\u067e\u064a \u062d\u0642 2019 \u062f \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0685\u06cc\u0693\u0646\u06cc\u0632 \u0628\u0646\u0633\u067c \u0644\u062e\u0648\u0627. \u067c\u0648\u0644 \u062d\u0642\u0648\u0646\u0647 \u062e\u0648\u0646\u062f\u064a \u062f\u064a.<\/p>\n<p>\u00a0\u062f \u0644\u0627\u0633\u064a \u06a9\u062a\u0627\u0628 \u0644\u0648\u0645\u0693\u06cd \u0646\u0633\u062e\u0647 \u067e\u0647 \u0647\u0633\u067e\u0627\u0646\u0648\u064a \u0627\u0648 \u067e\u0631\u062a\u06ab\u0627\u0644\u064a \u0646\u0633\u062e\u0648 \u06a9\u06d0 \u0634\u062a\u0648\u0646 \u0644\u0631\u064a. \u067e\u0647 \u0647\u0633\u067e\u0627\u0646\u0648\u064a \u0627\u0648 \u067e\u0631\u062a\u06ab\u0627\u0644\u064a \u06a9\u06d0 \u062f \u0644\u0627\u0633\u064a \u06a9\u062a\u0627\u0628 \u062f \u062f\u0648\u06cc\u0645\u06d0 \u0646\u0633\u062e\u06d0 \u0698\u0628\u0627\u0693\u06d0 \u0628\u0647 \u06a9\u0644\u0647 \u0686\u06d0 \u0634\u062a\u0648\u0646 \u0648\u0644\u0631\u064a \u067e\u0648\u0633\u067c \u0634\u064a.<\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][\/et_pb_column_inner][et_pb_column_inner type=&#8221;1_2&#8243; saved_specialty_column_type=&#8221;3_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||15px&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_button button_url=&#8221;https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/01\/Handbook-2018-PDF-One-File-v3-1.pdf&#8221; url_new_window=&#8221;on&#8221; button_text=&#8221;2nd Edition &#8211; English&#8221; button_alignment=&#8221;center&#8221; admin_label=&#8221;2nd Edition &#8211; English&#8221; _builder_version=&#8221;4.16&#8243; background_layout=&#8221;dark&#8221; custom_margin=&#8221;||20px&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;right&#8221; animation_intensity_slide=&#8221;25%&#8221; z_index_tablet=&#8221;500&#8243; custom_css_main_element=&#8221;width: 70%;&#8221; global_colors_info=&#8221;{}&#8221;]<br \/>\n[\/et_pb_button][et_pb_button button_url=&#8221;https:\/\/www.progeriaresearch.org\/assets\/files\/pdf\/PRF%20Handbook%20Spanish.pdf&#8221; url_new_window=&#8221;on&#8221; button_text=&#8221;1st Edition &#8211; Spanish&#8221; button_alignment=&#8221;center&#8221; admin_label=&#8221;1st Edition &#8211; Spanish&#8221; _builder_version=&#8221;4.16&#8243; background_layout=&#8221;dark&#8221; custom_margin=&#8221;||20px&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;right&#8221; animation_intensity_slide=&#8221;25%&#8221; z_index_tablet=&#8221;500&#8243; custom_css_main_element=&#8221;width: 70%;&#8221; global_colors_info=&#8221;{}&#8221;]<br \/>\n[\/et_pb_button][et_pb_button button_url=&#8221;https:\/\/www.progeriaresearch.org\/assets\/files\/pdf\/Handbook&#8212;Portuguese.pdf&#8221; button_text=&#8221;1st Edition &#8211; Portuguese&#8221; button_alignment=&#8221;center&#8221; admin_label=&#8221;1st Edition &#8211; Portuguese&#8221; _builder_version=&#8221;4.16&#8243; background_layout=&#8221;dark&#8221; custom_margin=&#8221;||20px&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;right&#8221; animation_intensity_slide=&#8221;25%&#8221; z_index_tablet=&#8221;500&#8243; custom_css_main_element=&#8221;width: 70%;&#8221; global_colors_info=&#8221;{}&#8221;]<br \/>\n[\/et_pb_button][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner custom_padding_last_edited=&#8221;on|phone&#8221; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;0|35px|0|0px|false|false&#8221; custom_padding_tablet=&#8221;|35px||35px||true&#8221; custom_padding_phone=&#8221;&#8221; animation_direction=&#8221;top&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column_inner saved_specialty_column_type=&#8221;3_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;Journal Articles&#8221; _builder_version=&#8221;4.17.6&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; z_index_tablet=&#8221;500&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4><strong>\u062f \u0698\u0648\u0631\u0646\u0627\u0644 \u0645\u0642\u0627\u0644\u06d0<\/strong><\/h4>\n<p class=\"m_5556619090296294739MsoNoSpacing\"><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35752705\/\" target=\"_blank\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/pubmed.ncbi.nlm.nih.gov\/35752705\/&amp;source=gmail&amp;ust=1658414740427000&amp;usg=AOvVaw3JN2-5dxsoBxFs9Lk6gXDY\" rel=\"noopener\">\u06a9\u0644\u0648\u0646\u0627\u0644 \u0647\u06cc\u0645\u0627\u062a\u067e\u0648\u0632\u06cc\u0633\u0633 \u067e\u0647 \u0647\u0686\u06cc\u0646\u0633\u0646 - \u06ab\u06cc\u0644\u0641\u0648\u0631\u0689 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0689\u0631\u0648\u0645 \u06a9\u06d0 \u0634\u062a\u0648\u0646 \u0646\u0644\u0631\u064a<\/a><\/strong><br \/><span><u><\/u><u><\/u><\/span><span>D\u00edez-D\u00edez M\u060c Amor\u00f3s-P\u00e9rez M\u060c de la Barrera J\u060c et al. [\u062f \u0686\u0627\u067e \u0685\u062e\u0647 \u0645\u062e\u06a9\u06d0 \u0622\u0646\u0644\u0627\u06cc\u0646 \u062e\u067e\u0648\u0631 \u0634\u0648\u06cc\u060c 2022 \u062c\u0648\u0646 25]. \u062c\u06cc\u0631\u0648\u0633\u06cc\u0646\u0633. 2022;10.1007\/s11357-022-00607-<wbr \/>2. doi:10.1007\/s11357-022-00607-2<\/span><\/p>\n<p><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29710166\/?from_term=Gordon+LB+Association+of+&amp;from_pos=1\" target=\"_blank\" rel=\"noopener noreferrer\">\u062f \u0644\u0648\u0646\u0627\u0641\u0631\u0646\u06cc\u0628 \u062f\u0631\u0645\u0644\u0646\u06d0 \u067c\u0648\u0644\u0646\u0647 \u062f \u0647\u0686\u06cc\u0646\u0633\u0646 - \u06ab\u06cc\u0644\u0641\u0648\u0631\u0689 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0689\u0631\u0648\u0645 \u0646\u0627\u0631\u0648\u063a\u0627\u0646\u0648 \u06a9\u06d0 \u062f \u0645\u0693\u06cc\u0646\u06d0 \u06a9\u0686\u06d0 \u0633\u0631\u0647 \u0647\u06cc\u0685 \u062f\u0631\u0645\u0644\u0646\u0647 \u0646\u0647.<\/a><\/strong><br \/>\u06ab\u0648\u0631\u0689\u0646 \u0627\u06cc\u0644 \u0628\u06cc\u060c \u0634\u0627\u067e\u06cc\u0644 \u0627\u06cc\u0686\u060c \u0645\u0627\u0633\u0627\u0631\u0648 J\u060c \u062f \u0627\u06ab\u0648\u0633\u062a\u06cc\u0646\u0648 RB Sr\u060c Brazier J\u060c Campbell SE\u060c Kleinman ME\u060c Kieran MW.Gordon LB\u060c et al. JAMA. 2018 \u0627\u067e\u0631\u06cc\u0644 24\u061b319(16):1687-1695. doi: 10.1001\/jama.2018.3264.<\/p>\n<p><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30450527\/?from_term=lessel+d&amp;from_page=4&amp;from_pos=4\" target=\"_blank\" rel=\"noopener noreferrer\">\u062f LMNA-\u0645\u0646\u0641\u064a \u0681\u0648\u0627\u0646 \u067e\u0631\u0648\u062c\u06cc\u0631\u0627\u06cc\u0689 \u0642\u0636\u06cc\u0648 \u062a\u062d\u0644\u06cc\u0644 \u062f \u0648\u06cc\u0689\u06cc\u0645\u06cc\u0646-\u0631\u0627\u0648\u062a\u06cc\u0646\u0633\u067c\u0631\u0648\u0686 \u067e\u0647 \u0685\u06cc\u0631 \u0633\u0646\u0689\u0631\u0648\u0645 \u06a9\u06d0 \u062f \u0628\u0627\u06cc\u0644\u06cc\u06a9 POLR3A \u062a\u063a\u06cc\u0631\u0627\u062a \u062a\u0627\u06cc\u06cc\u062f\u0648\u064a \u0627\u0648 \u062f PYCR1 \u062a\u063a\u06cc\u0631\u0627\u062a\u0648 \u0641\u06cc\u0646\u0648\u067c\u0627\u06cc\u067e\u06cc\u06a9 \u0633\u067e\u06cc\u06a9\u0679\u0631\u0645 \u067e\u0631\u0627\u062e\u0648\u064a.<\/a><\/strong><br \/>Lessel D, Ozel AB, Campbell SE, Saadi A, Arlt MF, McSweeney KM, Plaiasu V, Szakszon K, Sz\u0151ll\u0151s A, Rusu C, Rojas AJ, Lopez-Valdez J, Thiele H, N\u00fcrnberg P, Nickerson DA, Bamshad MJ, \u0644\u06cc \u062c\u06d0 \u0632\u06cc\u0689\u060c \u06a9\u0648\u0628\u06cc\u0634 \u0633\u06cc\u060c \u06ab\u0644\u0648\u0648\u0631 TW\u060c \u06ab\u0648\u0631\u0689\u0646 LB.Lessel D\u060c et al. \u0647\u0648\u0645 \u062c\u06cc\u0646\u067c. 2018 \u062f\u0633\u0645\u0628\u0631\u061b 137(11-12):921-939. doi: 10.1007\/s00439-018-1957-1. Epub 2018 Nov 19.Hum Genet. 2018. PMID: 30450527<\/p>\n<p><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29581305\/?from_term=dubose+a&amp;from_pos=1\" target=\"_blank\" rel=\"noopener noreferrer\">\u0627\u06cc\u0648\u0631\u0648\u0644\u06cc\u0645\u0633 \u062f \u0644\u0627\u0645\u06cc\u0646\u0648\u067e\u06cc\u062a\u064a \u0646\u0627\u0631\u0648\u063a\u0627\u0646\u0648 \u0641\u0627\u06cc\u0628\u0631\u0648\u0628\u0644\u0627\u0633\u062a\u0648\u0646\u0648 \u06a9\u06d0 \u062f \u0689\u06cc\u0631\u06cc \u0633\u06cc\u0644\u0648\u0644\u0631 \u0646\u06cc\u0645\u06ab\u0693\u062a\u06cc\u0627\u0648 \u0685\u062e\u0647 \u0698\u063a\u0648\u0631\u064a. <\/a><\/strong><br \/>DuBose AJ\u060c Lichtenstein ST\u060c Petrash NM\u060c Erdos MR\u060c Gordon LB\u060c Collins FS.DuBose AJ\u060c et al. Proc Natl Acad Sci US A. 2018 \u0627\u067e\u0631\u06cc\u0644 17;115(16):4206-4211. doi: 10.1073\/pnas.1802811115. Epub 2018 \u0645\u0627\u0631\u0686 26. Proc Natl Acad Sci US A. 2018. PMID: 29581305<\/p>\n<p><strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28756152\" target=\"_blank\" rel=\"noopener noreferrer\">\u062f \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u062f \u0633\u062a\u0631\u06ab\u0648 \u062f \u0633\u062a\u0631\u06ab\u0648 \u0681\u0627\u0646\u06ab\u0693\u062a\u06cc\u0627\u0648\u06d0.<br \/><\/a><\/strong>\u0645\u0627\u0646\u067c\u0627\u06ab\u0648\u0633 IS\u060c \u06a9\u0644\u06cc\u0646\u0645\u0646 ME\u060c \u06a9\u06cc\u0631\u0627\u0646 MW\u060c \u06ab\u0648\u0631\u0689\u0646 LB.<br \/>\u0627\u0645 J Ophthalmol. 2017 \u062c\u0648\u0644\u0627\u06cc 27. pii: S0002-9394(17)30317-3. doi: 10.1016\/j.ajo.2017.07.020. [\u0627\u06cc \u067e\u06cc\u0628 \u0644\u0647 \u0686\u0627\u067e \u0685\u062e\u0647 \u0645\u062e\u06a9\u06d0]<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27920058\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>\u06cc\u0648 \u0646\u0648\u06cc \u0633\u0648\u0645\u0627\u062a\u06cc\u06a9 \u0628\u062f\u0644\u0648\u0646 \u062f \u0647\u0686\u06cc\u0646\u0633\u0646 - \u06ab\u06cc\u0644\u0641\u0648\u0631\u0689 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0689\u0631\u0648\u0645 \u0633\u0631\u0647 \u067e\u0647 \u0645\u0627\u0634\u0648\u0645 \u06a9\u06d0 \u062c\u0632\u0648\u064a \u0646\u062c\u0627\u062a \u062a\u0631\u0644\u0627\u0633\u0647 \u06a9\u0648\u064a.<\/strong><br \/><\/a>\u0628\u0627\u0631 DZ\u060c Arlt MF\u060c Brazier JF\u060c Norris WE\u060c Campbell SE\u060c Chines P\u060c Larrieu D\u060c Jackson SP\u060c Collins FS\u060c Glover TW\u060c \u06ab\u0648\u0631\u0689\u0646 LB.<br \/>J Med Genet. 2017 \u0645\u0627\u0631\u0686\u061b 54(3):212-216. doi: 10.1136\/jmedgenet-2016-104295. Epub 2016 \u062f\u0633\u0645\u0628\u0631 5.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27799555\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>\u067e\u0647 \u067e\u0631\u0648\u062c\u0631\u0627\u06cc\u0689 \u0645\u0648\u0696\u06a9\u0627\u0646\u0648 \u06a9\u06d0 \u062f \u0632\u0693\u0647 \u0628\u0631\u06cc\u069a\u0646\u0627\u06cc\u06cc \u0646\u06cc\u0645\u06ab\u0693\u062a\u06cc\u0627\u0648\u06d0 \u0627\u0648 \u062f \u0647\u0686\u06cc\u0646\u0633\u0646 - \u06ab\u06cc\u0644\u0641\u0648\u0631\u0689 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0689\u0631\u0648\u0645 \u0646\u0627\u0631\u0648\u063a\u0627\u0646\u0648 \u06a9\u06d0 \u062f \u0627\u067c\u0648\u0645\u064a \u0644\u0627\u0645\u06cc\u0646\u0627 \u0628\u062f\u0644\u0648\u0646\u0648\u0646\u0648 \u0633\u0631\u0647.<\/strong><br \/><\/a>Rivera-Torres J, Calvo CJ, Llach A, Guzm\u00e1n-Mart\u00ednez G, Caballero R, Gonz\u00e1lez-G\u00f3mez C, Jim\u00e9nez-Borreguero LJ, Guadix JA, Osorio FG, L\u00f3pez-Ot\u00edn C, Herraiz-Mart\u00ednez A, Cabellina A, , Ben\u00edtez R, Gordon LB\u060c Jalife J\u060c P\u00e9rez-Pomares JM\u060c Tamargo J\u060c Delp\u00f3n E\u060c Hove-Madsen L\u060c Filgueiras-Rama D\u060c Andr\u00e9s V.<br \/>Proc Natl Acad Sci US A. 2016 \u0646\u0648\u0645\u0628\u0631 15;113(46):E7250-E7259. Epub 2016 \u0627\u06a9\u062a\u0648\u0628\u0631 31.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27400896\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>\u062f \u0647\u0686\u06cc\u0646\u0633\u0646 - \u06ab\u06cc\u0644\u0641\u0648\u0631\u0689 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0689\u0631\u0648\u0645 \u0633\u0631\u0647 \u067e\u0647 \u0645\u0627\u0634\u0648\u0645\u0627\u0646\u0648 \u06a9\u06d0 \u062f \u067e\u0631\u0648\u067c\u06cc\u0646 \u0641\u0627\u0631\u0646\u06cc\u0633\u06cc\u0644\u06cc\u0634\u0646 \u0645\u062e\u0646\u06cc\u0648\u06cc \u06a9\u0648\u0646\u06a9\u0648 \u0644\u0648\u0646\u0627\u0641\u0627\u0631\u0646\u06cc\u0628 \u060c \u067e\u0631\u0648\u0627\u0633\u062a\u0627\u062a\u06cc\u0646 \u0627\u0648 \u0632\u0648\u0644\u06cc\u0689\u0631\u0648\u0646\u06cc\u06a9 \u0627\u0633\u06cc\u062f \u06a9\u0644\u06cc\u0646\u06cc\u06a9\u064a \u0622\u0632\u0645\u0648\u06cc\u0646\u0647.<\/strong><br \/><\/a>\u06ab\u0648\u0631\u0689\u0646 LB\u060c \u06a9\u0644\u06cc\u0646\u0645\u0646 ME\u060c \u0645\u0627\u0633\u0627\u0631\u0648 J\u060c D&#039;Agostino RB Sr\u060c Shappell H\u060c Gehard-Herman M\u060c Smoot LB\u060c \u06ab\u0648\u0631\u0689\u0646 CM\u060c \u06a9\u0644\u06cc\u0648\u0644\u06cc\u0646\u0689 RH\u060c Nazarian A\u060c Snyder BD\u060c Ullrich NJ\u060c Silvera VM\u060c Liang MG\u060c Quinn N, \u0645\u0644\u0631 DT\u060c \u0647\u0648 SY\u060c \u0689\u0648\u067c\u0646 AA\u060c \u0644\u06cc\u067c\u0644\u0641\u06cc\u0644\u0689 K\u060c \u06ab\u0631\u06cc\u0631 \u0627\u06cc\u0645 \u0627\u06cc\u0645\u060c \u06a9\u06cc\u0631\u0627\u0646 \u0645\u06cc\u06ab\u0627\u0648\u0627\u067c.<br \/>\u06af\u0631\u062f\u0634. 2016 \u062c\u0648\u0644\u0627\u06cc 12\u061b 134(2):114-25. doi: 10.1161\/CIRCULATIONAHA.116.022188.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26564085\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>\u0647\u0686\u06cc\u0646\u0633\u0646 - \u06ab\u06cc\u0644\u0641\u0648\u0631\u0689 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0689\u0631\u0648\u0645.<\/strong><br \/><\/a>\u0627\u0644\u0631\u06cc\u0686 NJ\u060c \u06ab\u0648\u0631\u0689\u0646 LB.<br \/>\u0647\u06cc\u0646\u0689\u0628 \u06a9\u0644\u06cc\u0646 \u0646\u06cc\u0648\u0631\u0648\u0644. 2015\u061b132:249-64.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24795390\"><strong>\u062f \u0647\u0686\u06cc\u0646\u0633\u0646 - \u06ab\u06cc\u0644\u0641\u0648\u0631\u0689 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0689\u0631\u0648\u0645 \u06a9\u06d0 \u062f \u0628\u0642\u0627 \u067e\u0647 \u0627\u0693\u0647 \u062f \u0641\u0627\u0631\u0646\u06cc\u0633\u06cc\u06cc\u0644\u06cc\u0634\u0646 \u0645\u062e\u0646\u06cc\u0648\u06cc \u06a9\u0648\u0646\u06a9\u0648 \u0627\u063a\u06cc\u0632.<\/strong><br \/><\/a>\u06ab\u0648\u0631\u0689\u0646 LB\u060c \u0645\u0627\u0633\u0627\u0631\u0648 J\u060c D&#039;Agostino RB Sr\u060c Campbell SE\u060c Brazier J\u060c Brown WT\u060c Kleinman ME\u060c Kieran MW\u061b \u062f \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u06a9\u0644\u06cc\u0646\u06cc\u06a9\u064a \u0622\u0632\u0645\u0648\u06cc\u0646\u06d0 \u0647\u0645\u06a9\u0627\u0631\u064a.<br \/>\u06af\u0631\u062f\u0634. 2014 \u062c\u0648\u0644\u0627\u06cc 1\u061b130(1):27-34. doi: 10.1161\/CIRCULATIONAHA.113.008285. Epub 2014 \u0645\u06cc 2.<\/p>\n<p><strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24456199\">\u062f \u0647\u0686\u06cc\u0646\u0633\u0646 - \u06ab\u06cc\u0644\u0641\u0648\u0631\u0689 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0689\u0631\u0648\u0645 \u0644\u0648\u0645\u0693\u0646\u064a \u067e\u0648\u067c\u06a9\u064a \u0685\u0631\u06ab\u0646\u062f\u0648\u0646\u0647.<\/a>\u00a0<\/strong>Rork JF\u060c Huang JT\u060c \u06ab\u0648\u0631\u0689\u0646 LB\u060c \u06a9\u0644\u06cc\u0646\u0645\u0646 \u0627\u06cc\u0645\u060c \u06a9\u06cc\u0631\u0627\u0646 MW\u060c \u0644\u06cc\u0627\u0646\u06ab MG. \u062f \u067e\u06cc\u0689\u06cc\u067c\u0631 \u0689\u0631\u0645\u0627\u062a\u0648\u0644. 2014 \u062c\u0646\u0648\u0631\u064a 24: 1-7. doi: 10.1111\/pde.12284.<\/p>\n<p class=\"desc\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23897869\"><b>\u0639\u0635\u0628\u064a<\/b>\u00a0<b>\u0681\u0627\u0646\u06ab\u0693\u062a\u06cc\u0627\u0648\u06d0<\/b>\u00a0\u062f\u00a0<b>\u0647\u0686\u06cc\u0646\u0633\u0646 \u06ab\u06cc\u0644\u0641\u0648\u0631\u0689<\/b>\u00a0\u062f \u0644\u0648\u0646\u0627\u0641\u0627\u0631\u0646\u06cc\u0628 \u062f\u0631\u0645\u0644\u0646\u06d0 \u0648\u0631\u0648\u0633\u062a\u0647 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0689\u0631\u0648\u0645.<br \/><\/a>\u0627\u0644\u0631\u06cc\u0686 NJ\u060c \u06a9\u06cc\u0631\u0627\u0646 MW\u060c Miller DT\u060c Gordon LB\u060c Cho YJ\u060c Silvera VM\u060c Giobbie-Hurder A\u060c Neuberg D\u060c Kleinman ME. <i>\u0646\u06cc\u0648\u0631\u0648\u0644\u0648\u0698\u064a<\/i>. \u06f2\u06f0\u06f1\u06f3 \u062c\u0648\u0644\u0627\u06cc \u06f3\u06f0\u061b\u06f8\u06f1(\u06f5):\u06f4\u06f2\u06f7-\u06f3\u06f0. doi: 10.1212\/WNL.0b013e31829d85c0. Epub 2013 \u062c\u0648\u0646 28.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23179651\"><b>\u0627\u0646\u0681\u0648\u0631\u06ab\u0631\u064a<\/b>\u00a0<b>\u0681\u0627\u0646\u06ab\u0693\u062a\u06cc\u0627\u0648\u06d0<\/b>\u00a0\u062f\u00a0<b>\u0645\u063a\u0632<\/b>\u00a0<b>arteriopathy<\/b>\u00a0\u0627\u0648\u00a0<b>\u0636\u0631\u0628\u0647<\/b>\u00a0\u067e\u0647 \u0647\u0686\u06cc\u0646\u0633\u0646 - \u06ab\u06cc\u0644\u0641\u0648\u0631\u0689 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0689\u0631\u0648\u0645 \u06a9\u06d0.<\/a> \u0633\u0644\u0648\u06cc\u0631\u0627 VM\u060c \u06ab\u0648\u0631\u0689\u0646 LB\u060c Orbach DB\u060c Campbell SE\u060c Machan JT\u060c Ullrich NJ.<br \/><i>AJNR Am J \u0646\u06cc\u0648\u0631\u0648\u0631\u0627\u0689\u06cc\u0648\u0644<\/i>. 2013 \u0645\u06cc\u061b34(5):1091-7. doi: 10.3174\/ajnr.A3341. Epub 2012 \u062f \u0646\u0648\u0645\u0628\u0631 22.<\/p>\n<p class=\"desc\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22460337\"><b>\u062f \u06a9\u0631\u06cc\u0646\u06cc\u0648 \u0641\u0627\u0633\u06cc\u0644 \u063a\u06cc\u0631 \u0645\u0639\u0645\u0648\u0644\u064a \u062d\u0627\u0644\u062a\u0648\u0646\u0647<\/b>\u00a0\u067e\u0647\u00a0<b>\u0647\u0686\u06cc\u0646\u0633\u0646<\/b>- \u06ab\u06cc\u0644\u0641\u0648\u0631\u0689 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0689\u0631\u0648\u0645.<br \/><\/a>\u0627\u0644\u0631\u06cc\u0686 NJ\u060c \u0633\u0644\u0648\u06cc\u0631\u0627 VM\u060c \u06a9\u06cc\u0645\u0628\u0644 SE\u060c \u06ab\u0648\u0631\u0689\u0646 LB. <i>AJNR Am J \u0646\u06cc\u0648\u0631\u0648\u0631\u0627\u0689\u06cc\u0648\u0644<\/i>. \u06f2\u06f0\u06f1\u06f2 \u0633\u067e\u062a\u0645\u0628\u0631\u061b\u06f3\u06f3(\u06f8):\u06f1\u06f5\u06f1\u06f2-\u06f8. doi: 10.3174\/ajnr.A3088. Epub 2012 \u062f \u0645\u0627\u0631\u0686 29.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23012407\"><b>\u06a9\u0644\u06cc\u0646\u06cc\u06a9\u064a \u0645\u062d\u0627\u06a9\u0645\u0647<\/b>\u00a0\u062f a\u00a0<b>farnesyltransferase<\/b>\u00a0<b>\u0645\u062e\u0646\u06cc\u0648\u06cc \u06a9\u0648\u0646\u06a9\u06cc<\/b>\u00a0\u067e\u0647\u00a0<b>\u0645\u0627\u0634\u0648\u0645\u0627\u0646<\/b>\u00a0\u0633\u0631\u0647\u00a0<b>\u0647\u0686\u06cc\u0646\u0633\u0646<\/b>- \u06ab\u06cc\u0644\u0641\u0648\u0631\u0689 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0689\u0631\u0648\u0645.<\/a> \u06ab\u0648\u0631\u0689\u0646 LB\u060c \u06a9\u0644\u06cc\u0646\u0645\u0646 ME\u060c \u0645\u0644\u0631 DT\u060c \u0646\u06cc\u0648\u0628\u0631\u06ab DS\u060c \u062c\u06cc\u0648\u0628\u064a \u0647\u0631\u0689\u0631 A\u060c \u06ab\u06cc\u0631\u0627\u0631\u0689-\u0647\u0631\u0645\u0646 \u0627\u06cc\u0645\u060c \u0633\u0645\u0648\u067c \u0627\u06cc\u0644 \u0628\u06cc\u060c \u06ab\u0648\u0631\u0689\u0646 \u0633\u06cc \u0627\u06cc\u0645\u060c \u06a9\u0644\u06cc\u0648\u0644\u06cc\u0646\u0689 \u0622\u0631\u060c \u0633\u0646\u0627\u06cc\u0689\u0631 \u0628\u06cc \u0689\u06cc\u060c \u0641\u0644\u06cc\u06ab\u0648\u0631 \u0628\u06cc\u060c \u0628\u0634\u067e WR\u060c \u0633\u067c\u06cc\u067c\u06a9\u06cc\u0648\u0686 \u067e\u06cc\u060c \u0631\u06cc\u06ab\u0646 A\u060c \u0633\u0648\u0646\u06cc\u0633 A\u060c \u0631\u06cc\u0644\u06cc S, Ploski C, Correia A, Quinn N, Ulrich NJ, \u0646\u0632\u0627\u0631\u06cc\u0627\u0646 A\u060c Liang MG\u060c Huh SY\u060c Schwartzman A\u060c Kieran MW. <i>Proc Natl Acad Sci USA<\/i>. 2012 \u0627\u06a9\u062a\u0648\u0628\u0631 9;109(41):16666-71. doi: 10.1073\/pnas.1202529109. Epub 2012 \u0633\u067e\u062a\u0645\u0628\u0631 24<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22083160\"><b>\u0645\u06cc\u06a9\u0627\u0646\u06cc\u0632\u0645\u0648\u0646\u0647<\/b>\u00a0\u062f\u00a0<b>\u0648\u062e\u062a \u0645\u062e\u06a9\u06d0<\/b>\u00a0<b>\u0639\u0635\u0628\u064a<\/b>\u00a0<b>\u0632\u0693\u069a\u062a<\/b>\u00a0\u067e\u0647\u00a0<b>\u0645\u0627\u0634\u0648\u0645\u0627\u0646<\/b>\u00a0\u0633\u0631\u0647\u00a0<b>\u0647\u0686\u06cc\u0646\u0633\u0646<\/b>- \u06ab\u06cc\u0644\u0641\u0648\u0631\u0689 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0689\u0631\u0648\u0645.<\/a> \u06ab\u06cc\u0631\u0627\u0631\u0689 \u0647\u0631\u0645\u0646 \u0627\u06cc\u0645\u060c \u0633\u0645\u0648\u067c \u0627\u06cc\u0644 \u0628\u06cc\u060c \u0648\u06cc\u06a9 \u0627\u06cc\u0646\u060c \u06a9\u06cc\u0631\u0627\u0646 \u0645\u06cc\u06ab\u0627\u0648\u0627\u067c\u060c \u06a9\u0644\u06cc\u0646\u0645\u0646 ME\u060c \u0645\u0644\u0631 DT\u060c \u0634\u0648\u0627\u0631\u067c\u0632\u0645\u0627\u0646 A\u060c \u062c\u06cc\u0648\u0628\u06cc-\u0647\u0631\u0689\u0631 A\u060c \u0646\u06cc\u0648\u0628\u0631\u06ab \u0689\u064a\u060c \u06ab\u0648\u0631\u0689\u0646 \u0627\u06cc\u0644 \u0628\u06cc. <i>\u0644\u0648\u0693 \u0641\u0634\u0627\u0631<\/i>. \u06f2\u06f0\u06f1\u06f2 \u062c\u0646\u0648\u0631\u064a\u061b\u06f5\u06f9(\u06f1):\u06f9\u06f2-\u06f7. doi: 10.1161\/HypertensionaHA.111.180919. Epub 2011 \u062f \u0646\u0648\u0645\u0628\u0631 14.<\/p>\n<p class=\"desc\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22752073\"><strong>\u067e\u0647 \u0647\u0686\u06cc\u0646\u0633\u0646 - \u06ab\u06cc\u0644\u0641\u0648\u0631\u0689 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0689\u0631\u0648\u0645 \u06a9\u06d0 \u062f \u0631\u0627\u0689\u06cc\u0648\u06ab\u0631\u0627\u0641\u06cc\u06a9 \u0685\u0631\u06ab\u0646\u062f\u0648\u0646\u0648 \u0627\u062d\u062a\u0645\u0627\u0644\u064a \u0645\u0637\u0627\u0644\u0639\u0647.<\/strong><br \/><\/a>\u06a9\u0644\u06cc\u0648\u0644\u06cc\u0646\u0689 RH\u060c \u06ab\u0648\u0631\u0689\u0646 LB\u060c \u06a9\u0644\u06cc\u0646\u0645\u0646 ME\u060c \u0645\u0644\u0631 DT\u060c \u06ab\u0648\u0631\u0689\u0646 \u0633\u06cc \u0627\u06cc\u0645\u060c \u0633\u0646\u0627\u06cc\u0689\u0631 \u0628\u06cc \u0689\u06cc\u060c \u0646\u0632\u0627\u0631\u06cc\u0627\u0646 A\u060c \u062c\u06cc\u0648\u0628\u06cc-\u0647\u0648\u0631\u0689\u0631 A\u060c \u0646\u06cc\u0648\u0628\u0631\u06ab \u0689\u064a\u060c \u06a9\u06cc\u0631\u0627\u0646 MW. <i>\u067e\u06cc\u0689\u06cc\u067c\u0631 \u0631\u0627\u062f\u06cc\u0648\u0644<\/i>. \u06f2\u06f0\u06f1\u06f2 \u0633\u067e\u062a\u0645\u0628\u0631\u061b\u06f4\u06f2(\u06f9):\u06f1\u06f0\u06f8\u06f9-\u06f9\u06f8. doi: 10.1007\/s00247-012-2423-1. Epub 2012 \u062c\u0648\u0644\u0627\u06cc 1.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21980471\"><b>\u067c\u06cc\u067c<\/b>\u00a0\u0627\u0648\u00a0<b>\u0644\u0648\u0693<\/b>\u00a0<b>\u0685\u0631\u06ab\u0646\u062f\u0648\u0644<\/b>\u00a0<b>alleles<\/b>\u00a0\u062f LMNA \u062c\u06cc\u0646: \u062f \u0644\u0627\u0645\u06cc\u0646\u0648\u067e\u06cc\u062a\u064a \u0646\u0627\u0631\u0648\u063a\u06cd \u067e\u0631\u0627\u062e\u062a\u06cc\u0627 \u0644\u067e\u0627\u0631\u0647 \u0627\u063a\u06cc\u0632\u06d0.<\/a> \u0631\u0648\u0689\u0631\u06cc\u06ab\u0632 \u0627\u06cc\u0633\u060c \u0627\u06cc\u0631\u06a9\u0633\u0646 \u0627\u06cc\u0645. <i>PLOS One<\/i>. 2011;6(9):e25472. doi: 10.1371\/journal.pone.0025472. Epub 2011 \u0633\u067e\u062a\u0645\u0628\u0631 29.<br \/><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21445982\"><b><br \/>\u0647\u0686\u06cc\u0646\u0633\u0646 \u06ab\u06cc\u0644\u0641\u0648\u0631\u0689<\/b>\u00a0<b>\u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627<\/b>\u00a0\u06cc\u0648 \u062f\u06cc\u00a0<b>\u06a9\u0646\u06a9\u0627\u0644<\/b>\u00a0dysplasia<\/a> \u06ab\u0648\u0631\u0689\u0646 \u0633\u06cc \u0627\u06cc\u0645\u060c \u06ab\u0648\u0631\u0689\u0646 \u0627\u06cc\u0644 \u0628\u06cc\u060c \u0633\u0646\u0627\u06cc\u0689\u0631 \u0628\u06cc \u0689\u06cc\u060c \u0646\u0632\u0627\u0631\u06cc\u0627\u0646 A\u060c \u06a9\u0648\u06cc\u0646 \u0627\u06cc\u0646\u060c \u0647\u0648 \u0627\u06cc\u0633\u060c \u062c\u06cc\u0648\u0628\u06cc-\u0647\u0631\u0689\u0631 A\u060c \u0646\u06cc\u0648\u0628\u0631\u06ab \u0689\u064a\u060c \u06a9\u0644\u06cc\u0648\u0644\u06cc\u0646\u0689 \u0622\u0631\u060c \u06a9\u0644\u06cc\u0646\u0645\u0646 \u0627\u06cc\u0645\u060c \u0645\u0644\u0631 DT\u060c \u06a9\u06cc\u0631\u0627\u0646 MW. <i>J Bone Miner Res<\/i>. 2011 \u062c\u0648\u0644\u0627\u06cc\u061b 26 (7): 1670-9. doi: 10.1002\/jbmr.392.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20798379\"><b>\u062f \u0632\u0693\u0647 \u0631\u0646\u0681\u067e\u0648\u0647\u0646\u0647<\/b>\u00a0\u067e\u0647\u00a0<b>\u0647\u0686\u06cc\u0646\u0633\u0646<\/b>- \u06ab\u06cc\u0644\u0641\u0648\u0631\u0689 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627: \u062f \u0648\u06cc\u0633\u06a9\u0648\u0644\u0631 \u0633\u0631\u0647 \u0627\u0693\u06cc\u06a9\u0647<b>\u0631\u0646\u0681\u067e\u0648\u0647\u0646\u0647<\/b>\u00a0\u062f \u0632\u0693\u069a\u062a<\/a> Olive M, Harten I, Mitchell R, Beers JK, Djabali K, Cao K, Erdos MR, Blair C, Funke B, Smoot L, Gerhard-Herman M, Machan JT, Kutys R, Virmani R, Collins FS, Wight TN, \u0646\u0628\u06cc\u0644 \u0627\u06cc \u062c\u06cc\u060c \u06ab\u0648\u0631\u0689\u0646 \u0627\u06cc\u0644 \u0628\u06cc. <i>Arterioscler Thromb Vasc Biol<\/i>. 2010 \u0646\u0648\u0645\u0628\u0631\u061b 30 (11): 2301-9. doi: 10.1161\/ATVBAHA.110.209460. Epub 2010 \u0627\u06ab\u0633\u062a 26.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19236595\"><b>\u0647\u0686\u06cc\u0646\u0633\u0646 \u06ab\u06cc\u0644\u0641\u0648\u0631\u0689<\/b>\u00a0<b>\u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627<\/b>\u00a0<b>\u0633\u0646\u0689\u0631\u0648\u0645<\/b>:\u00a0<b>\u0634\u0641\u0627\u0647\u064a<\/b>\u00a0\u0627\u0648 craniofacial phenotypes.<\/a> \u0689\u0648\u0645\u06cc\u0646\u06ab\u0648 DL\u060c Trujillo MI\u060c Council SE\u060c Merideth MA\u060c Gordon LB\u060c Wu T\u060c Intron WJ\u060c Gahl WA\u060c Hart TC. <i>\u0632\u0628\u0627\u0646\u064a<\/i><i>\u00a0<\/i><i>\u0689\u06cc\u0633<\/i>. 2009 \u0627\u067e\u0631\u06cc\u0644\u061b 15(3): 187-95. doi: 10.1111\/j.1601-0825.2009.01521.x Epub 2009 \u0641\u0628\u0631\u0648\u0631\u064a 19.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18334552\"><b>\u067e\u0647 \u0646\u069a\u0647 \u0634\u0648\u064a<\/b>\u00a0<b>\u067c\u0631\u0627\u0646\u062c\u06cc\u0646\u06a9<\/b>\u00a0<b>\u0628\u06cc\u0627\u0646<\/b>\u00a0\u062f\u00a0<b>\u0628\u062f\u0644\u0648\u0646<\/b>\u00a0<b>\u0644\u0627\u0645\u0644 \u06a9\u06cc\u0696\u064a<\/b>\u00a0\u062f \u0647\u0686\u06cc\u0646\u0633\u0646 - \u06ab\u06cc\u0644\u0641\u0648\u0631\u0689 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0689\u0631\u0648\u0645 \u062f \u062e\u067e\u0631\u06cc\u062f\u0648 \u0627\u0648 \u062a\u062e\u0631\u06cc\u0628 \u06a9\u0648\u0646\u06a9\u064a \u0627\u06cc\u067e\u06cc\u0689\u0631\u0645\u0644 \u0646\u0627\u0631\u0648\u063a\u06cd \u0644\u0627\u0645\u0644 \u06a9\u06cc\u0696\u064a.<\/a> \u0633\u06cc\u06ab\u06cc\u0644\u06cc\u0633 \u0627\u06cc\u0686\u060c \u0631\u0648\u0632\u0646\u06ab\u0627\u0631\u0689\u067c\u0646 \u0648\u0627\u0626\u06cc\u060c \u062d\u0646\u06cc\u0641 \u0627\u06cc\u0645\u060c \u0627\u06cc\u0631\u0689\u0648\u0633 \u0627\u06cc\u0645 \u0622\u0631\u060c \u0631\u0648\u0632\u06cc\u0644 \u0628\u06cc\u060c \u06a9\u0648\u0644\u06cc\u0646\u0632 \u0627\u06cc\u0641 \u0627\u06cc\u0633\u060c \u0627\u06cc\u0631\u06a9\u0633\u0646 \u0627\u06cc\u0645. <i>J Cell Sci<\/i>. 2008 \u0627\u067e\u0631\u06cc\u0644 1\u061b 121 (Pt 7): 969-78. doi: 10.1242\/jcs.022913. Epub 2008 \u062f \u0645\u0627\u0631\u0686 11.<\/p>\n<p class=\"desc\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18708427\"><b>\u062f \u0628\u06cc\u0631\u062a\u0647 \u0631\u0627\u06ab\u0631\u0681\u06cc\u062f\u0648\u0646\u06a9\u064a<\/b>\u00a0<b>\u0641\u06cc\u0646\u0648\u067c\u0627\u06cc\u067e<\/b>\u00a0\u067e\u0647 a\u00a0<b>\u0645\u0648\u0696\u06a9<\/b>\u00a0\u062f \u0647\u0686\u06cc\u0646\u0633\u0646 - \u06ab\u06cc\u0644\u0641\u0648\u0631\u0689 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0689\u0631\u0648\u0645 \u0645\u0627\u0689\u0644.<br \/><\/a>\u0633\u06cc\u06ab\u06cc\u0644\u06cc\u0648\u0633 \u0627\u06cc\u0686\u060c \u0631\u0648\u0632\u0646\u06ab\u0627\u0631\u062f\u067c\u0646 \u0648\u0627\u0626\u06cc\u060c \u0634\u0645\u06cc\u062a \u0627\u06cc\u060c \u0633\u0648\u0646\u0646\u0627\u0628\u06cc\u0646\u0689 \u0633\u06cc\u060c \u0631\u0648\u0632\u06cc\u0644 \u0628\u06cc\u060c \u0627\u06cc\u0631\u06a9\u0633\u0646 \u0627\u06cc\u0645. <i>J Med Genet<\/i>. 2008 \u062f\u0633\u0645\u0628\u0631\u061b 45(12):794-801. doi: 10.1136\/jmg.2008.060772. Epub 2008 \u0627\u06ab\u0633\u062a 15.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18256394\"><b>\u0641\u06cc\u0646\u0648\u067c\u0627\u0626\u067e<\/b>\u00a0\u0627\u0648\u00a0<b>\u06a9\u0648\u0631\u0633<\/b>\u00a0\u062f\u00a0<b>\u0647\u0686\u06cc\u0646\u0633\u0646<\/b>- \u06ab\u06cc\u0644\u0641\u0648\u0631\u0689 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0689\u0631\u0648\u0645.<\/a> \u0645\u0631\u06cc\u062f\u06cc\u062a MA\u060c \u06ab\u0648\u0631\u0689\u0646 LB\u060c \u06a9\u0644\u0627\u0648\u0633 \u0627\u06cc\u0633\u060c \u0633\u0686\u062f\u06cc\u0648 \u0648\u06cc\u060c \u0633\u0645\u06cc\u067c AC\u060c \u067e\u06cc\u0631\u064a MB\u060c \u0628\u0631\u06cc\u0648\u0631 CC\u060c \u0632\u0627\u0644\u0648\u0633\u06a9\u064a \u0633\u064a\u060c \u06a9\u06cc\u0645 \u0627\u06cc\u0686 \u062c\u06d2\u060c \u0633\u0644\u06cc\u0645\u0627\u0646 \u0628\u06cc\u060c \u0628\u0631\u0648\u06a9\u0633 \u0628\u06cc \u067e\u06cc\u060c \u06ab\u06cc\u0631\u0628\u0631 \u0627\u06cc\u0644 \u0627\u06cc\u0686\u060c \u067c\u0631\u0646\u0631 \u0627\u06cc\u0645 \u0627\u06cc\u0644\u060c \u0689\u0648\u0645\u06cc\u0646\u06ab\u0648 DL\u060c \u0647\u0627\u0631\u067c TC\u060c \u06ab\u0631\u0627\u0641 \u062c\u06d2\u060c \u0631\u06cc\u0646\u0648\u0644\u0689\u0632 JC , Gropman A, Yanovski JA, Gerhard-Herman M, Collins FS\u060c Nabel EG\u060c Cannon RO 3rd\u060c Gahl WA\u060c Introne WJ. <i>N Engl J Med<\/i>. 2008 \u0641\u0628\u0631\u0648\u0631\u064a 7\u061b358(6):592-604. doi: 10.1056\/NEJMoa0706898.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17908771\"><b>\u0646\u0648\u06cc<\/b>\u00a0<b>\u062a\u06ab \u0631\u0627\u062a\u06ab<\/b>\u00a0\u062a\u0647\u00a0<b>\u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627<\/b>.<\/a> \u06a9\u06cc\u0631\u0627\u0646 \u0645\u06cc\u06ab\u0627\u0648\u0627\u067c\u060c \u06ab\u0648\u0631\u0689\u0646 \u0627\u06cc\u0644\u060c \u06a9\u0644\u06cc\u0645\u0646 \u0627\u06cc\u0645 \u067e\u06cc\u0689\u06cc\u0627\u067c\u0631\u06cc\u06a9\u0633. 2007 \u0627\u06a9\u062a\u0648\u0628\u0631\u061b 120(4):834-41. \u0628\u06cc\u0627\u06a9\u062a\u0646\u0647. \u062a\u06d0\u0631\u0648\u062a\u0646\u0647 \u067e\u0647 \u06a9\u06d0: <i>\u062f \u0645\u0627\u0634\u0648\u0645\u0627\u0646\u0648 \u062f\u0631\u0645\u0644\u0646\u0647<\/i>. 2007 \u062f\u0633\u0645\u0628\u0631\u061b 120(6):1405.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17908770\"><b>\u062f \u0646\u0627\u0631\u0648\u063a\u06cd \u0648\u062f\u0647<\/b>\u00a0\u067e\u0647\u00a0<b>\u0647\u0686\u06cc\u0646\u0633\u0646 \u06ab\u06cc\u0644\u0641\u0648\u0631\u0689<\/b>\u00a0\u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0689\u0631\u0648\u0645: \u067e\u0647 \u0648\u062f\u0647 \u0627\u0648 \u067e\u0631\u0627\u062e\u062a\u06cc\u0627 \u0627\u063a\u06cc\u0632\u0647.<\/a> \u06ab\u0648\u0631\u0689\u0646 \u0627\u06cc\u0644 \u0628\u06cc\u060c \u0645\u06a9 \u06a9\u0627\u0631\u067c\u06cc\u0646 KM\u060c \u062c\u06cc\u0648\u0628\u06cc-\u0647\u0631\u0689\u0631 A\u060c \u0645\u0686\u0627\u0646 JT\u060c \u06a9\u06cc\u0645\u0628\u0644 SE\u060c Berns SD\u060c Kieran MW. <i>\u062f \u0645\u0627\u0634\u0648\u0645\u0627\u0646\u0648 \u062f\u0631\u0645\u0644\u0646\u0647<\/i>. 2007 \u0627\u06a9\u062a\u0648\u0628\u0631\u061b 120(4):824-33.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15756215\"><b>\u06a9\u0645 \u0634\u0648\u06cc<\/b>\u00a0<b>adiponectin<\/b>\u00a0\u0627\u0648\u00a0<b>HDL \u06a9\u0648\u0644\u06cc\u0633\u067c\u0631\u0648\u0644<\/b>\u00a0\u067e\u0631\u062a\u0647\u00a0<b>\u0644\u0648\u0693 \u0634\u0648\u06cc<\/b>\u00a0<b>\u062f C- \u062a\u0639\u0627\u0645\u0644 \u0648\u0693 \u067e\u0631\u0648\u067c\u06cc\u0646<\/b>: \u067e\u0647 \u0647\u0686\u06cc\u0646\u0633\u0646 - \u06ab\u06cc\u0644\u0641\u0648\u0631\u0689 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0689\u0631\u0648\u0645 \u06a9\u06d0 \u062f \u0648\u062e\u062a \u062f\u0645\u062e\u0647 \u0627\u06cc\u062a\u0631\u0648\u0633\u06a9\u0644\u0631\u0648\u0633\u06cc\u0633 \u0628\u06cc\u0648\u0644\u0648\u0698\u064a \u062a\u0647 \u0627\u0634\u0627\u0631\u06d0.<\/a> \u06ab\u0648\u0631\u0689\u0646 LB\u060c \u0647\u0627\u0631\u067c\u06cc\u0646 IA\u060c \u067e\u06cc\u067c\u064a ME\u060c \u0644\u06cc\u0686\u067c\u06cc\u0646\u0633\u067c\u06cc\u0646 AH. <i>\u062c \u067e\u06cc\u0689\u06cc\u067c\u0631<\/i>. 2005 \u0645\u0627\u0631\u0686\u061b 146 (3): 336-41.<\/p>\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16129833\"><b>\u0645\u062e\u0646\u06cc\u0648\u06cc \u06a9\u0648\u064a<\/b>\u00a0<b>farnesylation<\/b>\u00a0\u062f \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0646 \u062f \u0647\u0686\u06cc\u0646\u0633\u0646 \u06ab\u06cc\u0644\u0641\u0648\u0631\u0689 \u062f \u0681\u0627\u0646\u06ab\u0693\u062a\u06cc\u0627\u0648 \u0627\u067c\u0648\u0645\u064a \u0628\u0644\u06cc\u0646\u06ab \u0645\u062e\u0647 \u0646\u06cc\u0633\u064a\u00a0<b>\u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627<\/b>\u00a0\u0633\u0646\u0689\u0631\u0648\u0645<\/a> Capell BC\u060c Erdos MR\u060c Madigan JP\u060c Fiordalisi JJ\u060c Varga R\u060c Conneely KN\u060c Gordon LB\u060c Der CJ\u060c Cox AD\u060c Collins FS. <i>Proc Natl Acad Sci USA<\/i>. 2005 \u0633\u067e\u062a\u0645\u0628\u0631 6\u061b 102 (36): 12879-84. Epub 2005 \u0627\u06ab\u0633\u062a 29<\/p>\n<p class=\"details\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15184648\"><b>\u062c\u0645\u0639 \u06a9\u0648\u0644<\/b>\u00a0\u062f\u00a0<b>\u0645\u062a\u063a\u06cc\u0631<\/b>\u00a0<b>\u0644\u0627\u0645\u06cc\u0646 \u0627\u06d0<\/b>\u00a0<b>\u0644\u0627\u0645\u0644\u0648\u0646\u0647<\/b>\u00a0\u067e\u0647 \u0647\u0686\u06cc\u0646\u0633\u0646 - \u06ab\u06cc\u0644\u0641\u0648\u0631\u0689 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0689\u0631\u0648\u0645 \u06a9\u06d0 \u062f \u0627\u067c\u0648\u0645\u064a \u062c\u0648\u0693\u069a\u062a \u06a9\u06d0 \u067e\u0631\u0645\u062e\u062a\u0644\u0644\u064a \u0628\u062f\u0644\u0648\u0646\u0648\u0646\u0647.<\/a> \u06af\u0648\u0644\u0689\u0645\u0646 RD\u060c \u0634\u0648\u0645\u0627\u06a9\u0631 DK\u060c Erdos MR\u060c Eriksson M\u060c Goldman AE\u060c Gordon LB\u060c Gruenbaum Y\u060c Khuon S\u060c Mendez M\u060c Varga R\u060c Collins FS. <i>Proc Natl Acad Sci USA<\/i>. 2004 \u062c\u0648\u0646 15\u061b 101 (24): 8963-8. Epub 2004 \u062c\u0648\u0646 7.<\/p>\n<h4><strong>\u06a9\u062a\u0627\u0628\u0648\u0646\u0647 \u0627\u0648 \u0627\u0633\u0646\u0627\u062f<\/strong><\/h4>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20301300\" target=\"_blank\" rel=\"noopener noreferrer\">\u0647\u0686\u06cc\u0646\u0633\u0646 - \u06ab\u06cc\u0644\u0641\u0648\u0631\u0689 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0689\u0631\u0648\u0645.<\/a>\u00a0 \u06ab\u0648\u0631\u0689\u0646 LB\u060c \u0628\u0631\u0627\u0648\u0646 WT\u060c \u06a9\u0648\u0644\u06cc\u0646\u0633 FS. \u067e\u0647 \u06a9\u06d0: Pagon RA\u060c Bird TD\u060c Dolan CR\u060c Stephens K\u060c \u0645\u062f\u06cc\u0631\u0627\u0646. GeneReviews [\u0627\u0646\u067c\u0631\u0646\u067c]. \u0633\u06cc\u067c\u0644 (WA): \u062f \u0648\u0627\u0634\u0646\u06ab\u067c\u0646 \u067e\u0648\u0647\u0646\u062a\u0648\u0646\u060c \u0633\u06cc\u067c\u0644\u061b \u06f1\u06f9\u06f9\u06f3-.<br \/>2003 \u0689\u06cc\u0633\u0645\u0628\u0631 12 [\u062a\u0627\u0632\u0647 \u0634\u0648\u06cc 2011 \u062c\u0646\u0648\u0631\u064a 06].<\/p>\n<div class=\"wpb_text_column wpb_content_element\">\n<div class=\"wpb_wrapper\">\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20301300\" target=\"_blank\" rel=\"noopener noreferrer\">\u0647\u0686\u06cc\u0646\u0633\u0646 - \u06ab\u06cc\u0644\u0641\u0648\u0631\u0689 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0689\u0631\u0648\u0645.<\/a>\u00a0 \u06ab\u0648\u0631\u0689\u0646 LB\u060c \u0628\u0631\u0627\u0648\u0646 WT\u060c \u06a9\u0648\u0644\u06cc\u0646\u0633 FS. \u067e\u0647 \u06a9\u06d0: Pagon RA\u060c Bird TD\u060c Dolan CR\u060c Stephens K\u060c \u0645\u062f\u06cc\u0631\u0627\u0646. GeneReviews [\u0627\u0646\u067c\u0631\u0646\u067c]. \u0633\u06cc\u067c\u0644 (WA): \u062f \u0648\u0627\u0634\u0646\u06ab\u067c\u0646 \u067e\u0648\u0647\u0646\u062a\u0648\u0646\u060c \u0633\u06cc\u067c\u0644\u061b \u06f1\u06f9\u06f9\u06f3-.<br \/>2003 \u0689\u06cc\u0633\u0645\u0628\u0631 12 [\u062a\u0627\u0632\u0647 \u0634\u0648\u06cc 2011 \u062c\u0646\u0648\u0631\u064a 06].<\/p>\n<p>\u062f \u0648\u062e\u062a \u062f\u0645\u062e\u0647 \u0639\u0645\u0631 \u0633\u0646\u0689\u0631\u0648\u0645 \u0647\u0686\u06cc\u0646\u0633\u0646 - \u06ab\u06cc\u0644\u0641\u0648\u0631\u0689 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627: \u062f \u0646\u0648\u0631\u0645\u0627\u0644 \u0639\u0645\u0631 \u067e\u0647 \u0627\u0693\u0647 \u0644\u06cc\u062f\u0648\u0646\u0647. \u06ab\u0648\u0631\u0689\u0646\u060c \u0644\u06cc\u0633\u0644\u064a. \u067e\u0647 \u0627\u0648\u0648\u0645\u0647 \u06ab\u06bc\u0647 \u06a9\u06d0 \u0685\u067e\u0631\u06a9\u06cc\u00a0<em>\u062f \u062c\u06cc\u0631\u06cc\u0627\u067c\u0631\u06cc\u06a9 \u062f\u0631\u0645\u0644\u0648 \u0627\u0648 \u062c\u06cc\u0631\u0648\u0646\u067c\u0648\u0644\u0648\u0698\u064a \u062f \u0628\u0631\u0648\u06a9\u0644\u0648\u0631\u0633\u067c \u062f\u0631\u0633\u064a \u06a9\u062a\u0627\u0628<\/em>. \u062f \u0686\u0627\u067e \u062d\u0642: 2010.<\/p>\n<p><em>LMNA<\/em>\u00a0\u0627\u0648 \u062f \u0647\u0686\u06cc\u0646\u0633\u0646 - \u06ab\u06cc\u0644\u0641\u0648\u0631\u0689 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0689\u0631\u0648\u0645 \u0627\u0648 \u0627\u0633\u0648\u0634\u06cc\u067c\u06cc\u0689 \u0644\u0627\u0645\u06cc\u0646\u0648\u067e\u06cc\u062a\u064a\u0632. \u06ab\u0648\u0631\u0689\u0646 LB\u060c \u0628\u0631\u0627\u0648\u0646 WT\u060c Rothman FG.  \u067e\u0647 CJ Epstein\u060c RP Erickson\u060c A. Wynshaw-Boris (Eds.) \u06a9\u06d0<em>\u00a0\u062f \u067e\u0631\u0627\u062e\u062a\u06cc\u0627 \u0632\u06cc\u0696\u06cc\u062f\u0646\u06d0 \u062a\u06d0\u0631\u0648\u062a\u0646\u06d0: \u062f \u0645\u0648\u0631\u0641\u0648\u06ab\u06cc\u0646\u06cc\u0633\u06cc\u0633 \u06a9\u0644\u06cc\u0646\u06cc\u06a9\u064a \u0627\u062e\u062a\u0644\u0627\u0644\u0627\u062a\u0648 \u0645\u0627\u0644\u06cc\u06a9\u0648\u0644 \u0627\u0633\u0627\u0633<\/em>\u00a0(2<sup>nd<\/sup>\u00a0ed.) \u0646\u06cc\u0648\u06cc\u0627\u0631\u06a9\u060c \u0646\u06cc\u0648\u06cc\u0627\u0631\u06a9: \u062f \u0627\u06a9\u0633\u0641\u0648\u0631\u0689 \u067e\u0648\u0647\u0646\u062a\u0648\u0646 \u067e\u0631\u06cc\u0633. 2008 139: 1219-1229.<\/p>\n<\/div>\n<\/div>\n<p>\u062f custom_margin=&quot;-2px||||||&quot; custom_padding=\u201d0|0px|0|0px|false|false\u201d z_index_tablet=\u201d500\u2033 Border_width_top=\u201d12px\u201d border_color_top=\u201d#00b2e2\u2033 global_module=\u201d133\u2033 locked=\u201doff\u201d global_colors_p=\u201d[et_colors_info] column_structure=\u201d1_4,1_4,1_2\u2033 make_equal=\u201don\u201dmodule_class=\u201det_pb_row_fullwidth\u201d _builder_version=\u201d4.16\u2033 \u0637\u0648\u0644=\u201d89%\u201d width_tablet=\u201d80%\u201d\u201d width_table=\u201d80%\u201d\u201d\u062f _\u0689\u06d0\u067c \u0641\u0648\u0646 =\u201d\u062f_\u0689\u06d0\u0689\u067c \u067e\u0647 \u0633\u0631 max_width=\u201d89%\u201d max_width_tablet=\u201d80%\u201d max_width_phone=\u201d\u201dmax_width_last_edited=\u201don|desktop\u201d z_index_tablet=\u201d500\u2033 make_fullwidth=\u201d\u067e\u0647\u201d \u067e\u0631\u0627\u062e\u0648\u0627\u0644\u064a_unit=\u201d01Tp_1\u201d% 100 \u0628\u0646\u062f\u201d \u067e\u0647 \u0627\u0646\u062f\u0627\u0632\u0647 Global_colors_info=\u201d{}\u201d][et_pb_column type=\u201d1_4\u2033 _builder_version=\u201d4.16\u2033 custom_padding=\u201d|||\u201d global_colors_info=&quot;{}&quot; custom_padding__hover=&quot;|||&quot;][et_pb_cta button_url=&quot;https:\/\/www.progeriaresearch.org\/newsletter-signup\/&quot; button_text=&quot;\u0627\u0648\u0633 \u0646\u0648\u0645 \u0644\u06cc\u06a9\u0646\u0647 \u0648\u06a9\u0693\u0626&quot; admin_label=&quot;\u062f \u062e\u0628\u0631 \u067e\u0627\u06bc\u064a \u0644\u067e\u0627\u0631\u0647 \u0644\u0627\u0633\u0644\u06cc\u06a9 \u0648\u06a9\u0693\u0626&quot; \u0645\u0627\u0689\u0644_\u06a9\u0644\u0627\u0633 =&quot;sign-btn&quot; _builder_version=&quot;4.16\u2033 header_font_size=\u201d25px\u201d background_color=\u201d#29327a\u201d animation_style=\u201dslide\u201d animation_direction=\u201dleft\u201d animation_intensity_slide=\u201d25%\u201d header_font_size_tablet=\u201d\u201d header_font_size_phone=\u201d30p header_font_size_last_edited=\u201don|desktop\u201d z_index_tablet=\u201d500\u2033 Border_radii=\u201don|25px|25px|25px|25px\u201d Global_colors_info=\u201d{}\u201d button_bg_color__hover_enabled=\u201don\u201dcolor_tverg=\u201dtp__tverg1\u201don\u201d. button_border_color__hover_enabled=&quot;on&quot;]<\/p>\n<h2>\u06ab\u0689\u0648\u0646 \u06a9\u0648\u0644<\/h2>\n<h2>\u0632\u0645\u0648\u0696 \u0644\u067e\u0627\u0631\u0647<\/h2>\n<h2>\u062e\u0628\u0631\u067e\u0627\u06bc\u0647!<\/h2>\n<p>[\/et_pb_cta][\/et_pb_column][et_pb_column type=\u201d1_4\u2033 _builder_version=\u201d4.16\u2033 custom_padding=\u201d|||\u201d global_colors_info=&quot;{}&quot; custom_padding__hover=&quot;|||&quot;][et_pb_cta button_url=&quot;https:\/\/progeriaresearch.donorsupport.co\/-\/XZHJVWZR&quot; button_text=&quot;\u0627\u0648\u0633 \u0645\u0631\u0633\u062a\u0647 \u0648\u06a9\u0693\u0626&quot; admin_label=&quot;\u067e\u0647 \u06ab\u0689\u0647\u060c \u0645\u0648\u0696 \u0628\u0647 \u062f\u0631\u0645\u0644\u0646\u0647 \u0648\u0645\u0648\u0645\u0626! \u00bb module_class = &quot;sign-btn&quot; _builder_version=&quot;4.16&quot; header_font_size=&quot;25px&quot; background_color=&quot;#29327a&quot; animation_style=&quot;slide&quot; animation_direction=&quot;left&quot; animation_intensity_slide=&quot;T_font_slide=&quot;T_font_size=&quot;251 \u067c\u0627\u0628\u0644\u06cc\u067c header_font_size_phone=&quot;30px&quot; header_font_size_last_edited=&quot;on|desktop&quot; body_font_size_tablet=&quot;&quot; body_font_size_phone=&quot;&quot; body_font_size_last_edited=&quot;on|desktop&quot; z_index_tablet=&quot;500\u2033 border_radii=\u201don|25px|25px|25px|25px\u201d global_colors_info=\u201d{}\u201d button_bg_color__hover_enabled=\u201don\u201d button_bg_color__hover=\u201d#8fd2ed\u201d button_border_color__hover_enabled=\u201d]<\/p>\n<h2>\u067e\u0647 \u06ab\u0689\u0647\u060c \u0645\u0648\u0696<\/h2>\n<h2><em>\u0628\u0647<\/em><\/h2>\n<h2>\u0639\u0644\u0627\u062c \u067e\u06cc\u062f\u0627 \u06a9\u0693\u0647!<\/h2>\n<p>[\/et_pb_cta][\/et_pb_column][et_pb_column \u0689\u0648\u0644=\u201d1_2\u2033 _\u062c\u0648\u0693\u0648\u0646\u06a9\u06cc_\u0646\u0633\u062e\u0647=\u201d4.16\u2033 \u062f\u0648\u062f\u06cc\u0632_\u067e\u06cc\u0689\u06cc\u0646\u06ab=\u201d||\u201d global_colors_info=\u201d{}\u201d custom_padding__hover=\u201d||\u201d][et_pb_image src=\u201dhttps:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2023\/06\/2023-footer-strip-5.png\u201d title_text=\u201d2023 \u0641\u0648\u067c\u0631 \u067e\u067c\u0647 5\u2033 _builder_version=\u201d4.21.0\u2033 _module_preset=\u201ddefault\u201d custom_margin=\u201d35px|||false|false\u201d global_colors_info=\u201d{}\u201d][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; disabled_on=&#8221;off|off|off&#8221; _builder_version=&#8221;4.16&#8243; border_width_bottom=&#8221;55px&#8221; border_color_bottom=&#8221;#29327a&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_fullwidth_header _builder_version=&#8221;4.16&#8243; title_font=&#8221;||||||||&#8221; title_font_size=&#8221;55&#8243; background_color=&#8221;#29327a&#8221; background_image=&#8221;https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2020\/12\/Jes.jpg&#8221; background_position=&#8221;center_left&#8221; custom_padding=&#8221;11.5vw||11.5vw||true&#8221; custom_padding_tablet=&#8221;&#8221; custom_padding_phone=&#8221;|56px||&#8221; custom_padding_last_edited=&#8221;on|desktop&#8221; title_font_size_tablet=&#8221;45px&#8221; title_font_size_phone=&#8221;40px&#8221; title_font_size_last_edited=&#8221;on|phone&#8221; z_index_tablet=&#8221;500&#8243; custom_css_main_element=&#8221;background-position: center 18% !important;&#8221; global_colors_info=&#8221;{}&#8221;] Medical Database [\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;1&#8243; specialty=&#8221;on&#8221; padding_left_1=&#8221;35px&#8221; padding_left_2=&#8221;35px&#8221; padding_2_tablet=&#8221;|||0px&#8221; padding_2_phone=&#8221;|||0px&#8221; padding_2_last_edited=&#8221;on|desktop&#8221; module_class_1=&#8221;sidebar-secondary-nav&#8221; module_class=&#8221;handprint-bg&#8221; _builder_version=&#8221;4.16&#8243; background_image=&#8221;https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/blue-handprint-only.png&#8221; parallax=&#8221;on&#8221; parallax_method=&#8221;off&#8221; inner_width=&#8221;100%&#8221; inner_max_width=&#8221;100%&#8221; custom_padding=&#8221;0|0px|54px|0px|false|false&#8221; z_index_tablet=&#8221;500&#8243; border_width_top=&#8221;10px&#8221; border_color_top=&#8221;#8fd2ed&#8221; use_custom_width=&#8221;on&#8221; width_unit=&#8221;off&#8221; custom_width_percent=&#8221;100%&#8221; [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"\t\t\t\t[vc_row][vc_column][vc_custom_heading text=\"Medical Database\" font_container=\"tag:h1|text_align:center\" use_theme_fonts=\"yes\"][vc_column_text]<strong>What is the International Medical and Research Database?<\/strong>\r\n\r\nWe collect the medical records for children with Progeria from all over the world. Then we look at every aspect of medical care that has been given to the children. We perform statistical analyses, and look at what treatments have worked for maintaining quality of life and what treatments have not worked. Most doctors have only seen one child with Progeria, and they are not sure what to do when the child needs things like heart medications, anesthesia, and proper physical therapy. We have the ability to give advice to the doctors and their families based on this database program.\r\n\r\nThe Progeria Research Foundation is collaborating with Brown University Center for Gerontology and Health Care Research for this wonderful project. The Brown Center has many years of experience with creating and analyzing healthcare databases.\r\n\r\nWe also use the medical records to understand more about the basis of disease in Progeria, which serves as a springboard for new research in Progeria and in the diseases of aging such as heart disease. This may lead to clues for new treatments for the children and for all of us!\r\n\r\nThere has never been a centralized childhood Progeria database from which to draw health care information. This has led to unintentional clinical maltreatment of patients, misdiagnoses and delayed diagnoses, simply because caretakers do not know which medical strategies have been successful with other Progeria children and which have not. The goal of this project is to collect the health care records for children with Progeria and develop a centralized health database for use by health care professionals, medical researchers, and families of children with Progeria.\r\n\r\n<strong>Aims of the Database<\/strong>\r\n<ul>\r\n \t<li>To describe in detail what treatment strategies have been successful, and what treatments have failed for the medical issues faced by children with HGPS. This may help the families and their doctors understand how to best care for children with Progeria.<\/li>\r\n \t<li>To provide health care recommendations to families in non-medical language about the issues that are important to the quality of life for children with HGPS.<\/li>\r\n \t<li>The database is a resource for gaining new insights into the nature of HGPS and into the nature of other diseases such as atherosclerosis, which in turn will serve to stimulate the advancement of new research projects.<\/li>\r\n<\/ul>\r\n<strong>Institutional Review Board Approvals:<\/strong>\r\n\r\nThe PRF Medical and Research Database is Institutional Review Board (IRB) approved by the Rhode Island Hospital and the Brown University Committees on the Protection of Human Subjects. Rhode Island Hospital Federal Wide Assurance FWA00001230, Study CMTT# 0152-01, Brown University Federal Wide Assurance FWA 00004460, Study CMTT# 0211991243\r\n\r\n<strong>Publications Stemming From The Progeria Research Foundation Medical and Research Database<\/strong>\r\n\r\nThe Progeria Research Foundation Medical and Research Database has contributed to the following medical publications:\r\n\r\n<strong>Clinical Care Handbook<\/strong>\r\n\r\n<em>The Progeria Handbook; A Guide for Families and Health Care Providers of Children with Progeria.<\/em> Gordon, Leslie B., Executive Editor. Copyright 2019 by The Progeria Research Foundation. All rights reserved.\r\n\r\n<img src=\"https:\/\/www.progeriaresearch.org\/assets\/images\/iconPDF.gif\" width=\"34\" height=\"20\" \/> <a href=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/01\/Handbook-2018-PDF-One-File-v3-1.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Click here\u00a0<\/a>\u00a0to download the second edition of the Handbook in English.\r\n\r\nThe first edition of the handbook is available in Spanish and Portuguese versions. Translations of the second edition of the handbook in Spanish and Portuguese will be posted when available.\r\n\r\n<a href=\"https:\/\/www.progeriaresearch.org\/assets\/files\/pdf\/PRF%20Handbook%20Spanish.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><img src=\"https:\/\/www.progeriaresearch.org\/assets\/images\/iconPDF.gif\" width=\"34\" height=\"20\" \/><\/a>\u00a0<a href=\"https:\/\/www.progeriaresearch.org\/assets\/files\/pdf\/PRF%20Handbook%20Spanish.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Click here<\/a> to download the Handbook in Spanish.\r\n\r\n<a href=\"https:\/\/www.progeriaresearch.org\/assets\/files\/pdf\/PRF%20Handbook%20Spanish.pdf\"><img src=\"https:\/\/www.progeriaresearch.org\/assets\/images\/iconPDF.gif\" width=\"34\" height=\"20\" \/><\/a>\u00a0<a href=\"https:\/\/www.progeriaresearch.org\/assets\/files\/pdf\/Handbook---Portuguese.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Click here<\/a> to download the Handbook in Portuguese.\r\n\r\n<strong>Journal Articles<\/strong>\r\n\r\n<strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28756152\" target=\"_blank\" rel=\"noopener noreferrer\">Ophthalmologic\u00a0Features\u00a0of\u00a0Progeria.\r\n<\/a><\/strong>Mantagos IS, Kleinman ME, Kieran MW, Gordon LB.\r\nAm J Ophthalmol. 2017 Jul 27. pii: S0002-9394(17)30317-3. doi: 10.1016\/j.ajo.2017.07.020. [Epub ahead of print]\r\n\r\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27920058\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>A\u00a0novel\u00a0somatic\u00a0mutation\u00a0achieves\u00a0partial rescue in a child with Hutchinson-Gilford progeria syndrome.<\/strong>\r\n<\/a>Bar DZ, Arlt MF, Brazier JF, Norris WE, Campbell SE, Chines P, Larrieu D, Jackson SP, Collins FS, Glover TW, Gordon LB.\r\nJ Med Genet. 2017 Mar;54(3):212-216. doi: 10.1136\/jmedgenet-2016-104295. Epub 2016 Dec 5.\r\n\r\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27799555\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Cardiac\u00a0electrical\u00a0defects\u00a0in\u00a0progeroid\u00a0mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations.<\/strong>\r\n<\/a>Rivera-Torres J, Calvo CJ, Llach A, Guzm\u00e1n-Mart\u00ednez G, Caballero R, Gonz\u00e1lez-G\u00f3mez C, Jim\u00e9nez-Borreguero LJ, Guadix JA, Osorio FG, L\u00f3pez-Ot\u00edn C, Herraiz-Mart\u00ednez A, Cabello N, Vallmitjana A, Ben\u00edtez R, Gordon LB, Jalife J, P\u00e9rez-Pomares JM, Tamargo J, Delp\u00f3n E, Hove-Madsen L, Filgueiras-Rama D, Andr\u00e9s V.\r\nProc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7250-E7259. Epub 2016 Oct 31.\r\n\r\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27400896\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Clinical Trial\u00a0of the\u00a0Protein Farnesylation\u00a0Inhibitors\u00a0Lonafarnib, Pravastatin, and Zoledronic Acid in Children With Hutchinson-Gilford Progeria Syndrome.<\/strong>\r\n<\/a>Gordon LB, Kleinman ME, Massaro J, D'Agostino RB Sr, Shappell H, Gerhard-Herman M, Smoot LB, Gordon CM, Cleveland RH, Nazarian A, Snyder BD, Ullrich NJ, Silvera VM, Liang MG, Quinn N, Miller DT, Huh SY, Dowton AA, Littlefield K, Greer MM, Kieran MW.\r\nCirculation. 2016 Jul 12;134(2):114-25. doi: 10.1161\/CIRCULATIONAHA.116.022188.\r\n\r\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26564085\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Hutchinson-Gilford progeria syndrome.<\/strong>\r\n<\/a>Ullrich NJ, Gordon LB.\r\nHandb Clin Neurol. 2015;132:249-64.\r\n\r\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24795390\"><strong>Impact\u00a0of\u00a0farnesylation\u00a0inhibitors\u00a0on\u00a0survival\u00a0in hutchinson-gilford progeria syndrome.<\/strong>\r\n<\/a>Gordon LB, Massaro J, D'Agostino RB Sr, Campbell SE, Brazier J, Brown WT, Kleinman ME, Kieran MW; Progeria Clinical Trials Collaborative.\r\nCirculation. 2014 Jul 1;130(1):27-34. doi: 10.1161\/CIRCULATIONAHA.113.008285. Epub 2014 May 2.\r\n\r\n<strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24456199\">Initial\u00a0Cutaneous\u00a0Manifestations of Hutchinson-Gilford Progeria Syndrome.<\/a>\u00a0<\/strong>Rork JF, Huang JT, Gordon LB, Kleinman M, Kieran MW, Liang MG. Pediatr Dermatol. 2014 Jan 24: 1-7. doi: 10.1111\/pde.12284.\r\n<p class=\"desc\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23897869\"><b>Neurologic<\/b>\u00a0<b>features<\/b>\u00a0of\u00a0<b>Hutchinson-Gilford<\/b>\u00a0progeria syndrome after lonafarnib treatment.\r\n<\/a>Ullrich NJ, Kieran MW, Miller DT, Gordon LB, Cho YJ, Silvera VM, Giobbie-Hurder A, Neuberg D, Kleinman ME. <i>Neurology<\/i>. 2013 Jul 30;81(5):427-30. doi: 10.1212\/WNL.0b013e31829d85c0. Epub 2013 Jun 28.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23179651\"><b>Imaging<\/b>\u00a0<b>characteristics<\/b>\u00a0of\u00a0<b>cerebrovascular<\/b>\u00a0<b>arteriopathy<\/b>\u00a0and\u00a0<b>stroke<\/b>\u00a0in Hutchinson-Gilford progeria syndrome.<\/a> Silvera VM, Gordon LB, Orbach DB, Campbell SE, Machan JT, Ullrich NJ.\r\n<i>AJNR Am J Neuroradiol<\/i>. 2013 May;34(5):1091-7. doi: 10.3174\/ajnr.A3341. Epub 2012 Nov 22.<\/p>\r\n<p class=\"desc\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22460337\"><b>Craniofacial abnormalities<\/b>\u00a0in\u00a0<b>Hutchinson<\/b>-Gilford progeria syndrome.\r\n<\/a>Ullrich NJ, Silvera VM, Campbell SE, Gordon LB. <i>AJNR Am J Neuroradiol<\/i>. 2012 Sep;33(8):1512-8. doi: 10.3174\/ajnr.A3088. Epub 2012 Mar 29.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23012407\"><b>Clinical trial<\/b>\u00a0of a\u00a0<b>farnesyltransferase<\/b>\u00a0<b>inhibitor<\/b>\u00a0in\u00a0<b>children<\/b>\u00a0with\u00a0<b>Hutchinson<\/b>-Gilford progeria syndrome.<\/a> Gordon LB, Kleinman ME, Miller DT, Neuberg DS, Giobbie-Hurder A, Gerhard-Herman M, Smoot LB, Gordon CM, Cleveland R, Snyder BD, Fligor B, Bishop WR, Statkevich P, Regen A, Sonis A, Riley S, Ploski C, Correia A, Quinn N, Ullrich NJ, Nazarian A, Liang MG, Huh SY, Schwartzman A, Kieran MW. <i>Proc Natl Acad Sci U S A<\/i>. 2012 Oct 9;109(41):16666-71. doi: 10.1073\/pnas.1202529109. Epub 2012 Sep 24<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22083160\"><b>Mechanisms<\/b>\u00a0of\u00a0<b>premature<\/b>\u00a0<b>vascular<\/b>\u00a0<b>aging<\/b>\u00a0in\u00a0<b>children<\/b>\u00a0with\u00a0<b>Hutchinson<\/b>-Gilford progeria syndrome.<\/a> Gerhard-Herman M, Smoot LB, Wake N, Kieran MW, Kleinman ME, Miller DT, Schwartzman A, Giobbie-Hurder A, Neuberg D, Gordon LB. <i>Hypertension<\/i>. 2012 Jan;59(1):92-7. doi: 10.1161\/HYPERTENSIONAHA.111.180919. Epub 2011 Nov 14.<\/p>\r\n<p class=\"desc\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22752073\"><strong>A\u00a0prospective study\u00a0of\u00a0radiographic\u00a0manifestations\u00a0in Hutchinson-Gilford progeria syndrome.<\/strong>\r\n<\/a>Cleveland RH, Gordon LB, Kleinman ME, Miller DT, Gordon CM, Snyder BD, Nazarian A, Giobbie-Hurder A, Neuberg D, Kieran MW. <i>Pediatr Radiol<\/i>. 2012 Sep;42(9):1089-98. doi: 10.1007\/s00247-012-2423-1. Epub 2012 Jul 1.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21980471\"><b>Low<\/b>\u00a0and\u00a0<b>high<\/b>\u00a0<b>expressing<\/b>\u00a0<b>alleles<\/b>\u00a0of the LMNA gene: implications for laminopathy disease development.<\/a> Rodr\u00edguez S, Eriksson M. <i>PLoS One<\/i>. 2011;6(9):e25472. doi: 10.1371\/journal.pone.0025472. Epub 2011 Sep 29.\r\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21445982\"><b>\r\nHutchinson-Gilford<\/b>\u00a0<b>progeria<\/b>\u00a0is a\u00a0<b>skeletal<\/b>\u00a0dysplasia.<\/a> Gordon CM, Gordon LB, Snyder BD, Nazarian A, Quinn N, Huh S, Giobbie-Hurder A, Neuberg D, Cleveland R, Kleinman M, Miller DT, Kieran MW. <i>J Bone Miner Res<\/i>. 2011 Jul;26(7):1670-9. doi: 10.1002\/jbmr.392.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20798379\"><b>Cardiovascular pathology<\/b>\u00a0in\u00a0<b>Hutchinson<\/b>-Gilford progeria: correlation with the vascular<b>pathology<\/b>\u00a0of aging.<\/a> Olive M, Harten I, Mitchell R, Beers JK, Djabali K, Cao K, Erdos MR, Blair C, Funke B, Smoot L, Gerhard-Herman M, Machan JT, Kutys R, Virmani R, Collins FS, Wight TN, Nabel EG, Gordon LB. <i>Arterioscler Thromb Vasc Biol<\/i>. 2010 Nov;30(11):2301-9. doi: 10.1161\/ATVBAHA.110.209460. Epub 2010 Aug 26.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19236595\"><b>Hutchinson-Gilford<\/b>\u00a0<b>progeria<\/b>\u00a0<b>syndrome<\/b>:\u00a0<b>oral<\/b>\u00a0and craniofacial phenotypes.<\/a> Domingo DL, Trujillo MI, Council SE, Merideth MA, Gordon LB, Wu T, Introne WJ, Gahl WA, Hart TC. <i>Oral<\/i><i>\u00a0<\/i><i>Dis<\/i>. 2009 Apr;15(3):187-95. doi: 10.1111\/j.1601-0825.2009.01521.x. Epub 2009 Feb 19.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18334552\"><b>Targeted<\/b>\u00a0<b>transgenic<\/b>\u00a0<b>expression<\/b>\u00a0of the\u00a0<b>mutation<\/b>\u00a0<b>causing<\/b>\u00a0Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease.<\/a> Sagelius H, Rosengardten Y, Hanif M, Erdos MR, Rozell B, Collins FS, Eriksson M. <i>J Cell Sci<\/i>. 2008 Apr 1;121(Pt 7):969-78. doi: 10.1242\/jcs.022913. Epub 2008 Mar 11.<\/p>\r\n<p class=\"desc\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18708427\"><b>Reversible<\/b>\u00a0<b>phenotype<\/b>\u00a0in a\u00a0<b>mouse<\/b>\u00a0model of Hutchinson-Gilford progeria syndrome.\r\n<\/a>Sagelius H, Rosengardten Y, Schmidt E, Sonnabend C, Rozell B, Eriksson M. <i>J Med Genet<\/i>. 2008 Dec;45(12):794-801. doi: 10.1136\/jmg.2008.060772. Epub 2008 Aug 15.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18256394\"><b>Phenotype<\/b>\u00a0and\u00a0<b>course<\/b>\u00a0of\u00a0<b>Hutchinson<\/b>-Gilford progeria syndrome.<\/a> Merideth MA, Gordon LB, Clauss S, Sachdev V, Smith AC, Perry MB, Brewer CC, Zalewski C, Kim HJ, Solomon B, Brooks BP, Gerber LH, Turner ML, Domingo DL, Hart TC, Graf J, Reynolds JC, Gropman A, Yanovski JA, Gerhard-Herman M, Collins FS, Nabel EG, Cannon RO 3rd, Gahl WA, Introne WJ. <i>N Engl J Med<\/i>. 2008 Feb 7;358(6):592-604. doi: 10.1056\/NEJMoa0706898.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17908771\"><b>New<\/b>\u00a0<b>approaches<\/b>\u00a0to\u00a0<b>progeria<\/b>.<\/a> Kieran MW, Gordon L, Kleinman M. Pediatrics. 2007 Oct;120(4):834-41. Review. Erratum in: <i>Pediatrics<\/i>. 2007 Dec;120(6):1405.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17908770\"><b>Disease progression<\/b>\u00a0in\u00a0<b>Hutchinson-Gilford<\/b>\u00a0progeria syndrome: impact on growth and development.<\/a> Gordon LB, McCarten KM, Giobbie-Hurder A, Machan JT, Campbell SE, Berns SD, Kieran MW. <i>Pediatrics<\/i>. 2007 Oct;120(4):824-33.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15756215\"><b>Reduced<\/b>\u00a0<b>adiponectin<\/b>\u00a0and\u00a0<b>HDL cholesterol<\/b>\u00a0without\u00a0<b>elevated<\/b>\u00a0<b>C-reactive protein<\/b>: clues to the biology of premature atherosclerosis in Hutchinson-Gilford Progeria Syndrome.<\/a> Gordon LB, Harten IA, Patti ME, Lichtenstein AH. <i>J Pediatr<\/i>. 2005 Mar;146(3):336-41.<\/p>\r\n<p class=\"Title1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16129833\"><b>Inhibiting<\/b>\u00a0<b>farnesylation<\/b>\u00a0of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford\u00a0<b>progeria<\/b>\u00a0syndrome.<\/a> Capell BC, Erdos MR, Madigan JP, Fiordalisi JJ, Varga R, Conneely KN, Gordon LB, Der CJ, Cox AD, Collins FS. <i>Proc Natl Acad Sci U S A<\/i>. 2005 Sep 6;102(36):12879-84. Epub 2005 Aug 29<\/p>\r\n<p class=\"details\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15184648\"><b>Accumulation<\/b>\u00a0of\u00a0<b>mutant<\/b>\u00a0<b>lamin A<\/b>\u00a0<b>causes<\/b>\u00a0progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome.<\/a> Goldman RD, Shumaker DK, Erdos MR, Eriksson M, Goldman AE, Gordon LB, Gruenbaum Y, Khuon S, Mendez M, Varga R, Collins FS. <i>Proc Natl Acad Sci U S A<\/i>. 2004 Jun 15;101(24):8963-8. Epub 2004 Jun 7.<\/p>\r\n<strong>Books and Documents<\/strong>\r\n\r\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20301300\" target=\"_blank\" rel=\"noopener noreferrer\">Hutchinson-Gilford Progeria Syndrome.<\/a>\u00a0 Gordon LB, Brown WT, Collins FS. In: Pagon RA, Bird TD, Dolan CR, Stephens K, editors. GeneReviews [Internet]. Seattle (WA): University of Washington, Seattle; 1993-.\r\n2003 Dec 12 [updated 2011 Jan 06].\r\n\r\nThe Premature Aging Syndrome Hutchinson-Gilford Progeria: Insights Into Normal Aging. Gordon, Leslie. Chapter in the 7th edition of <em>Brocklehurst\u2019s Textbook of Geriatric Medicine and Gerontology<\/em>. Copyright: 2010.\r\n\r\n<em>LMNA<\/em> and the Hutchinson-Gilford Progeria Syndrome and Associated Laminopathies. Gordon LB, Brown WT, Rothman FG. \u00a0In C. J. Epstein, R. P. Erickson, A. Wynshaw-Boris (Eds.)<em> Inborn Errors of Development: The molecular basis of clinical disorders of morphogenesis<\/em> (2<sup>nd<\/sup> ed.). New York, NY: Oxford University Press. 2008 139: 1219-1229.[\/vc_column_text][vc_column_text]Sam passed away on January 10, 2014, leaving a legacy of inspiration that now drives PRF and its supporters to continue the quest for a cure, with more determination than ever. <a href=\"https:\/\/www.progeriaresearch.org\/sam-berns-102396-0110141.html\">Click here<\/a> to learn more about this remarkable young man.[\/vc_column_text][vc_column_text]Together with caring, dedicated board members and other generous volunteers, The Progeria Research Foundation was created to raise awareness, educate and help the families, their doctors, researchers and the general public about Hutchinson-Gilford Progeria Syndrome. In addition, PRF funds medical research and runs research-related programs specifically aimed at finding the cause*, treatments, and cure for this syndrome.[\/vc_column_text][vc_column_text]Since its inception, PRF has benefited from the leadership of Attorney Audrey Gordon, Sam's aunt, who serves as the organization's President and Executive Director.[\/vc_column_text][vc_column_text]<strong>Did you know?<\/strong>\r\n\r\nWith the exception of our staff, everyone involved with PRF is a volunteer! Our Board of Directors, Clerk, Treasurer, committee members, translators, fund-raisers, etc. all devote their time, energy and talents to furthering our mission without pay. As a result, our administrative costs are very low. This leaves more money to devote to medical research and raising public awareness, which ultimately lead to finding a cure for Progeria.[\/vc_column_text][vc_column_text css=\".vc_custom_1508790933490{background-color: #ffffff !important;}\"]\r\n<p class=\"\">Leslie B. Gordon, MD, PhD, is PRF's Medical Director. She is also the Principal Investigator of PRF's research-related programs: The PRF International Registry, Cell & Tissue Bank, Medical & Research Database, and Diagnostics Testing Program, and co-author on the historic Progeria gene finding and treatment discovery*.<\/p>\r\n[\/vc_column_text][vc_column_text css=\".vc_custom_1488054553154{background-color: #ffffff !important;}\"]\r\n<p class=\"\">* Thanks to PRF's efforts, in April 2003 PRF and the National Institutes of Health announced that <a href=\"https:\/\/www.progeriaresearch.org\/identification_of_gene_gives_hope_to_children_with_progeria.html\">the cause of Progeria, a mutation in the LMNA gene, was found<\/a>, and in September 2012, <a href=\"https:\/\/www.progeriaresearch.org\/first-ever-progeria-treatment.html\">the first-ever treatment was discovered.<\/a><\/p>\r\n[\/vc_column_text][vc_column_text css=\".vc_custom_1488054565202{background-color: #ffffff !important;}\"]There is much work to be done and little resources with which to do so. We cannot do it alone. With your support, the cure will be discovered for these wonderful children.[\/vc_column_text][vc_column_text css=\".vc_custom_1488054579010{background-color: #ffffff !important;}\"]Together, we <em>WILL<\/em> find the cure.[\/vc_column_text][\/vc_column][\/vc_row]\t\t","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-788","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Database | The Progeria Research Foundation<\/title>\n<meta name=\"description\" content=\"As part of our continued efforts in finding the cure, PRF collects the medical records for children with Progeria from all over the world.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.progeriaresearch.org\/ps\/medical-database\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Database | The Progeria Research Foundation\" \/>\n<meta property=\"og:description\" content=\"As part of our continued efforts in finding the cure, PRF collects the medical records for children with Progeria from all over the world.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.progeriaresearch.org\/ps\/medical-database\/\" \/>\n<meta property=\"og:site_name\" content=\"The Progeria Research Foundation\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ProgeriaResearch\/\" \/>\n<meta property=\"article:modified_time\" content=\"2023-09-21T16:51:17+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@Progeria\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"11 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.progeriaresearch.org\/fr\/medical-database\/\",\"url\":\"https:\/\/www.progeriaresearch.org\/fr\/medical-database\/\",\"name\":\"Database | The Progeria Research Foundation\",\"isPartOf\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/ta\/#website\"},\"datePublished\":\"2017-02-26T18:53:03+00:00\",\"dateModified\":\"2023-09-21T16:51:17+00:00\",\"description\":\"As part of our continued efforts in finding the cure, PRF collects the medical records for children with Progeria from all over the world.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/fr\/medical-database\/#breadcrumb\"},\"inLanguage\":\"ps\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.progeriaresearch.org\/fr\/medical-database\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.progeriaresearch.org\/fr\/medical-database\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.progeriaresearch.org\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Medical Database\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.progeriaresearch.org\/ta\/#website\",\"url\":\"https:\/\/www.progeriaresearch.org\/ta\/\",\"name\":\"The Progeria Research Foundation\",\"description\":\"For the Children \u2665 For the Cure\",\"publisher\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/ta\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.progeriaresearch.org\/ta\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ps\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.progeriaresearch.org\/ta\/#organization\",\"name\":\"The Progeria Research Foundation\",\"url\":\"https:\/\/www.progeriaresearch.org\/ta\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ps\",\"@id\":\"https:\/\/www.progeriaresearch.org\/ta\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/05\/PRF_Logo_2019_optimized.png\",\"contentUrl\":\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/05\/PRF_Logo_2019_optimized.png\",\"width\":300,\"height\":86,\"caption\":\"The Progeria Research Foundation\"},\"image\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/ta\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/ProgeriaResearch\/\",\"https:\/\/x.com\/Progeria\",\"https:\/\/www.instagram.com\/progeriaresearch\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Database | The Progeria Research Foundation","description":"As part of our continued efforts in finding the cure, PRF collects the medical records for children with Progeria from all over the world.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.progeriaresearch.org\/ps\/medical-database\/","og_locale":"en_US","og_type":"article","og_title":"Database | The Progeria Research Foundation","og_description":"As part of our continued efforts in finding the cure, PRF collects the medical records for children with Progeria from all over the world.","og_url":"https:\/\/www.progeriaresearch.org\/ps\/medical-database\/","og_site_name":"The Progeria Research Foundation","article_publisher":"https:\/\/www.facebook.com\/ProgeriaResearch\/","article_modified_time":"2023-09-21T16:51:17+00:00","twitter_card":"summary_large_image","twitter_site":"@Progeria","twitter_misc":{"Est. reading time":"11 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.progeriaresearch.org\/fr\/medical-database\/","url":"https:\/\/www.progeriaresearch.org\/fr\/medical-database\/","name":"Database | The Progeria Research Foundation","isPartOf":{"@id":"https:\/\/www.progeriaresearch.org\/ta\/#website"},"datePublished":"2017-02-26T18:53:03+00:00","dateModified":"2023-09-21T16:51:17+00:00","description":"As part of our continued efforts in finding the cure, PRF collects the medical records for children with Progeria from all over the world.","breadcrumb":{"@id":"https:\/\/www.progeriaresearch.org\/fr\/medical-database\/#breadcrumb"},"inLanguage":"ps","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.progeriaresearch.org\/fr\/medical-database\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.progeriaresearch.org\/fr\/medical-database\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.progeriaresearch.org\/"},{"@type":"ListItem","position":2,"name":"Medical Database"}]},{"@type":"WebSite","@id":"https:\/\/www.progeriaresearch.org\/ta\/#website","url":"https:\/\/www.progeriaresearch.org\/ta\/","name":"\u062f \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0685\u06cc\u0693\u0646\u06cc\u0632 \u0628\u0646\u0633\u067c","description":"\u062f \u0645\u0627\u0634\u0648\u0645\u0627\u0646\u0648 \u0644\u067e\u0627\u0631\u0647 \u2665 \u062f \u062f\u0631\u0645\u0644\u0646\u06d0 \u0644\u067e\u0627\u0631\u0647","publisher":{"@id":"https:\/\/www.progeriaresearch.org\/ta\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.progeriaresearch.org\/ta\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ps"},{"@type":"Organization","@id":"https:\/\/www.progeriaresearch.org\/ta\/#organization","name":"\u062f \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0685\u06cc\u0693\u0646\u06cc\u0632 \u0628\u0646\u0633\u067c","url":"https:\/\/www.progeriaresearch.org\/ta\/","logo":{"@type":"ImageObject","inLanguage":"ps","@id":"https:\/\/www.progeriaresearch.org\/ta\/#\/schema\/logo\/image\/","url":"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/05\/PRF_Logo_2019_optimized.png","contentUrl":"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/05\/PRF_Logo_2019_optimized.png","width":300,"height":86,"caption":"The Progeria Research Foundation"},"image":{"@id":"https:\/\/www.progeriaresearch.org\/ta\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/ProgeriaResearch\/","https:\/\/x.com\/Progeria","https:\/\/www.instagram.com\/progeriaresearch\/"]}]}},"_links":{"self":[{"href":"https:\/\/www.progeriaresearch.org\/ps\/wp-json\/wp\/v2\/pages\/788","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.progeriaresearch.org\/ps\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.progeriaresearch.org\/ps\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.progeriaresearch.org\/ps\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.progeriaresearch.org\/ps\/wp-json\/wp\/v2\/comments?post=788"}],"version-history":[{"count":0,"href":"https:\/\/www.progeriaresearch.org\/ps\/wp-json\/wp\/v2\/pages\/788\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.progeriaresearch.org\/ps\/wp-json\/wp\/v2\/media?parent=788"}],"curies":[{"name":"\u0689\u0628\u0644\u06cc\u0648 \u067e\u064a","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}