{"id":2130,"date":"2005-07-16T20:44:48","date_gmt":"2005-07-16T20:44:48","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?p=2130"},"modified":"2020-12-09T11:10:16","modified_gmt":"2020-12-09T16:10:16","slug":"blocking-proteins","status":"publish","type":"post","link":"https:\/\/www.progeriaresearch.org\/ps\/2005\/07\/16\/blocking-proteins\/","title":{"rendered":"\u062f \u067e\u0631\u0648\u067c\u06cc\u0646 \u0641\u0627\u0631\u0646\u06cc\u0633\u06cc\u0644 \u067c\u0631\u0627\u0646\u0633\u0641\u06cc\u0631\u06cc\u0632 \u0628\u0646\u062f\u0648\u0644 \u062f \u0645\u0648\u0696\u06a9 \u0641\u0627\u06cc\u0628\u0631\u0648\u0628\u0644\u0627\u0633\u067c\u0648\u0646\u0648 \u06a9\u06d0 \u0627\u067c\u0648\u0645\u064a \u0628\u0644\u06cc\u0646\u06ab \u062a\u0647 \u0648\u062f\u0647 \u0648\u0631\u06a9\u0648\u064a \u0686\u06d0 \u067e\u0647 \u0646\u069a\u0647 \u0634\u0648\u064a \u0647\u0686\u06cc\u0646\u0633\u0646 - \u06ab\u06cc\u0644 \u0644\u0631\u064a"},"content":{"rendered":"<p>[et_pb_section fb_built=\u201d1\u2033 _builder_version=\u201d3.22\u2033][et_pb_row _builder_version=\u201d3.25\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201drepeat\u201d][et_pb_column type=\u201d4_4\u2033 _builder_version=\u201d3.25\u2033 custom_padding=\u201d||\u201d custom_padding__hover=\u201d||\u201d][et_pb_text _builder_version=\u201d4.6.5\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201drepeat\u201d hover_enabled=\u201d0\u2033 sticky_enabled=\u201d0\u2033]<\/p>\n<p><em>\u062f \u0639\u0644\u0648\u0645\u0648 \u0645\u0644\u064a \u0627\u06a9\u0627\u0689\u0645\u06cd \u0628\u0647\u06cc\u0631\u060c \u062c\u0648\u0644\u0627\u06cc \u06f2\u06f0\u06f0\u06f5<\/em><\/p>\n<p>* \u062f \u0634\u0627\u0648 \u0627\u06cc\u0686 \u06cc\u0627\u0646\u06ab \u0644\u062e\u0648\u0627\u060c \u062c\u0648\u0644\u06cc\u0627 I. \u062a\u0648\u062a\u060c \u06cc\u0627\u0646 \u0647\u0648\u060c \u0633\u0644\u06cc\u0645\u06cc\u0632 \u0633\u0646\u0689\u0648\u0648\u0627\u0644\u060c \u0633\u067c\u06cc\u0641\u0646 \u062c\u06cc \u06cc\u0646\u06ab\u060c \u0627\u0648 \u0644\u0648\u0631\u06cc\u0646 \u062c\u06cc \u0641\u0648\u0646\u06ab\u060c \u062f \u0689\u06cc\u0648\u06cc\u0689 \u06ab\u06cc\u0641\u06cc\u0646 \u062f \u0637\u0628 \u069a\u0648\u0648\u0646\u0681\u064a\u060c UCLA\u061b \u0645\u0627\u0631\u06ab\u0631\u06cc\u062a\u0627 \u0645\u06cc\u062a\u0627\u060c \u062f \u06a9\u0627\u0644\u06cc\u0641\u0648\u0631\u0646\u06cc\u0627 \u067e\u0648\u0647\u0646\u062a\u0648\u0646\u060c \u0633\u0627\u0646 \u0641\u0631\u0627\u0646\u0633\u0633\u06a9\u0648\u061b \u067e\u0631\u0648\u06cc\u0646 \u0628\u06cc\u0646\u0689\u06cc\u0644 \u0627\u0648 \u0645\u0627\u06cc\u06a9\u0644 \u0627\u06cc\u0686 \u062c\u06cc\u0644\u0628\u060c \u062f \u0648\u0627\u0634\u0646\u06ab\u067c\u0646 \u067e\u0648\u0647\u0646\u062a\u0648\u0646\u060c \u0633\u06cc\u067c\u0644\u061b \u0645\u0627\u0631\u062a\u06cc\u0646 \u0627\u0648 \u0628\u0631\u06ab\u0648\u060c \u062f \u0633\u0647\u0644\u06ab\u0631\u06cc\u0646\u0633\u06a9\u0627 \u067e\u0648\u0647\u0646\u062a\u0648\u0646 \u0631\u0648\u063a\u062a\u0648\u0646\u060c \u0633\u0648\u06cc\u0689\u0646<\/p>\n<p>\u062f \u0647\u0686\u06cc\u0646\u0633\u0646 - \u06ab\u06cc\u0644\u0641\u0648\u0631\u0689 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0689\u0631\u0648\u0645 (HGPS) \u062f \u062c\u06cc\u0646 \u067e\u0647 \u0646\u069a\u0647 \u0634\u0648\u064a \u0645\u0648\u0696\u06a9 \u0645\u0627\u0689\u0644 \u0631\u0627\u0645\u06cc\u0646\u0681\u062a\u0647 \u06a9\u0648\u0644\u0648 \u0648\u0631\u0648\u0633\u062a\u0647 \u060c \u0644\u06cc\u06a9\u0648\u0627\u0644\u0627\u0646\u0648 \u062f\u0627 \u062b\u0627\u0628\u062a\u0647 \u06a9\u0693\u0647 \u0686\u06d0 \u062f \u067e\u0631\u0648\u067c\u06cc\u0646 \u0641\u0627\u0631\u0646\u0633\u06cc\u0644\u06cc\u0634\u0646 \u067e\u0647 \u0646\u0648\u0645 \u062f \u067e\u0631\u0648\u0633\u06d0 \u0645\u062e\u0646\u06cc\u0648\u06cc \u062f \u0641\u0627\u0631\u0646\u06cc\u0633\u06cc\u0644 \u067c\u0631\u0627\u0646\u0633\u0641\u0631\u0627\u0633 \u0627\u0646\u0627\u0628\u06cc\u067c\u0631\u0632 (FTIs) \u0633\u0631\u0647 \u06a9\u0648\u0644\u06cc \u0634\u064a \u062f \u0627\u067c\u0648\u0645\u064a \u0644\u0641\u0627\u0641\u06d0 \u0632\u06cc\u0627\u0646 \u0645\u062e\u0647 \u0648\u0646\u06cc\u0633\u064a. \u0645\u062a\u063a\u06cc\u0631 \u067e\u0631\u0648\u067c\u06cc\u0646 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0646 \u0645\u0637\u0627\u0644\u0639\u06d0 \u0648\u0693\u0627\u0646\u062f\u06cc\u0632 \u06a9\u0648\u064a \u0686\u06d0 \u062d\u062c\u0631\u06d0 \u062f \u062f\u06d0 \u0637\u0631\u06cc\u0642\u06d0 \u067e\u0647 \u06a9\u0627\u0631\u0648\u0644\u0648 \u0633\u0631\u0647 \u062a\u0631\u0645\u06cc\u0645 \u06a9\u06cc\u062f\u06cc \u0634\u064a.<\/p>\n<p>\u067e\u0647 HGPS \u06a9\u06d0 mutant prelamin A \u0686\u06d0 \u067e\u0647 \u0639\u0627\u0645 \u0689\u0648\u0644 \u062f \u067e\u0631\u0648\u062c\u0631\u06cc\u0646 \u067e\u0647 \u0646\u0648\u0645 \u06cc\u0627\u062f\u06cc\u0696\u064a\u060c \u062f \u0628\u062f\u0644\u0648\u0646 \u0644\u0647 \u0627\u0645\u0644\u0647 \u0631\u0627\u0645\u06cc\u0646\u0681\u062a\u0647 \u06a9\u06cc\u0696\u064a <em>LMNA <\/em>\u0686\u06d0 \u062f \u067e\u0631\u06cc\u0644\u0627\u0645\u06cc\u0646 A \u062f\u0646\u0646\u0647 \u062f 50 \u0627\u0645\u06cc\u0646\u0648 \u0627\u0633\u06cc\u062f\u0648\u0646\u0648 \u0644\u0647 \u0645\u06cc\u0646\u0681\u0647 \u0648\u0693\u0648 \u0644\u0627\u0645\u0644 \u06a9\u06cc\u0696\u064a \u0627\u0648 \u062f \u0644\u0627\u0645\u06cc\u0646 A \u0628\u0627\u0644\u063a \u06a9\u06cc\u062f\u0648 \u0644\u067e\u0627\u0631\u0647 \u062f \u0646\u0648\u0631\u0645\u0627\u0644 \u067e\u0631\u0648\u0633\u0633 \u0645\u062e\u0647 \u0646\u06cc\u0633\u064a. \u067e\u0647 \u062d\u062c\u0631\u0648 \u06a9\u06d0 \u062f \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0646 \u0634\u062a\u0648\u0646 \u062f \u0627\u067c\u0648\u0645\u064a \u0644\u0627\u0645\u06cc\u0646\u06d0 \u0628\u0634\u067e\u0693\u062a\u06cc\u0627 \u0628\u0627\u0646\u062f\u06d0 \u0645\u0646\u0641\u064a \u0627\u063a\u06cc\u0632\u0647 \u06a9\u0648\u064a \u0686\u06d0 \u067e\u0647 \u067e\u0627\u06cc\u0644\u0647 \u06a9\u06d0 \u062f \u0647\u0633\u062a\u0648\u064a \u0646\u06cc\u0648\u06a9\u0644\u06cc \u0627\u0648 \u0627\u067c\u0648\u0645\u064a \u0628\u0644\u0628\u0648\u0646\u0648 \u067e\u0647 \u067e\u0627\u06cc\u0644\u0647 \u06a9\u06d0 \u0631\u0627\u0645\u06cc\u0646\u0681\u062a\u0647 \u06a9\u06cc\u0696\u064a.<\/p>\n<p>\u0641\u0648\u0646\u06ab \u0627\u0648 \u062f \u0647\u063a\u0647 \u0689\u0644\u06d0 \u067e\u0647 \u062f\u06d0 \u067e\u0631\u0648\u0633\u0647 \u06a9\u06d0 \u062f FTI \u0627\u063a\u06cc\u0632\u06d0 \u0648\u0685\u06cc\u0693\u0644\u06d0 \u0627\u0648 \u0648\u0645\u0648\u0646\u062f\u0644\u0647 \u0686\u06d0 \u062f\u0627 \u062f \u0627\u062a\u0648\u0645\u064a \u0634\u06a9\u0644 \u067e\u0647 \u0627\u0693\u0647 \u062f \u067e\u0627\u0645 \u0648\u0693 \u069a\u0647 \u0648\u0627\u0644\u06cc \u0644\u0627\u0645\u0644 \u0634\u0648\u06cc (\u062f \u0646\u06cc\u0645\u06ab\u0693\u062a\u06cc\u0627 \u06a9\u0645\u0648\u0644 \u0627\u0648 \u0632\u06cc\u0627\u0646\u0645\u0646 \u0634\u0648\u064a \u0646\u06cc\u0648\u06a9\u0644\u06cc).<\/p>\n<p>&quot;\u062f\u0627 \u0645\u0637\u0627\u0644\u0639\u0627\u062a \u062f \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0644\u067e\u0627\u0631\u0647 \u062f \u062f\u0631\u0645\u0644\u0646\u06d0 \u0627\u062d\u062a\u0645\u0627\u0644\u064a \u0633\u062a\u0631\u0627\u062a\u06cc\u0698\u064a \u0648\u0693\u0627\u0646\u062f\u06cc\u0632 \u06a9\u0648\u064a&quot; \u0634\u0631\u06cc\u06a9 \u0644\u06cc\u06a9\u0648\u0627\u0644 \u0689\u0627\u06a9\u067c\u0631 \u0633\u067c\u06cc\u0648\u0646 \u06cc\u0646\u06ab \u0648\u0627\u064a\u064a \u060c &quot;\u062f\u0627 \u0627\u0645\u06cc\u062f \u0631\u0627\u067e\u0648\u0631\u062a\u0647 \u06a9\u0648\u064a \u0686\u06d0 FTIs \u0628\u0647 \u067e\u0647 \u0646\u0647\u0627\u06cc\u062a \u06a9\u06d0 \u062f \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u062f\u0631\u0645\u0644\u0646\u06d0 \u0644\u067e\u0627\u0631\u0647 \u06ab\u067c\u0648\u0631 \u062b\u0627\u0628\u062a \u0634\u064a.&quot;<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;3.22&#8243;][et_pb_row _builder_version=&#8221;3.25&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.6.5&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;] Proceedings National Academy of Sciences, July 2005 * By Shao H. Yang, Julia I. Toth, Yan Hu, Salemiz Sandoval, Stephen G. Young, and Loren G. Fong, David Geffen School of Medicine, UCLA; Margarita Meta, University of California, San [&hellip;]<\/p>","protected":false},"author":1,"featured_media":2043,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"<p>[vc_custom_heading text=\"Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts containing a targeted Hutchinson-Gil\" font_container=\"tag:h1|text_align:left\" use_theme_fonts=\"yes\"]Blocking protein improves nuclear blebbing in mouse fibroblasts containing a targeted Hutchinson-Gilford Progeria syndrome mutation.<\/p><p><em>Proceedings National Academy of Sciences, July 2005<\/em><\/p><p>* By Shao H. Yang, Julia I. Toth, Yan Hu, Salemiz Sandoval, Stephen G. Young, and Loren G. Fong, David Geffen School of Medicine, UCLA; Margarita Meta, University of California, San Francisco; Pravin Bendale and Michael H. Gelb, University of Washington, Seattle; Martin O. Bergo, Sahlgrenska University Hospital, Sweden<\/p><p>After creating a gene-targeted mouse model of Hutchinson-Gilford Progeria Syndrome (HGPS), the authors set out to prove that the inhibition of a process called protein farnesylation with farnesyltransferase inhibitors (FTIs) can block the damage to the nuclear envelope caused by the mutant protein progerin. The studies suggest the cells can be repaired using this approach.<\/p><p>The mutant prelamin A in HGPS, commonly called progerin, is caused by a mutation in <em>LMNA <\/em>that results in the deletion of 50 amino acids within prelamin A and prevents normal processing to mature lamin A. The presence of progerin in cells adversely affects the integrity of the nuclear lamina, resulting in misshapen nuclei and nuclear blebs.<\/p><p>Fong and his group examined the effects of an FTI on this process and found that it resulted in a striking improvement on nuclear shape (reduced misshapen and damaged nuclei).<\/p><p>\"These studies suggest a possible treatment strategy for Progeria\" says co-author Dr. Steven Young, \"raising the hope that FTIs might ultimately prove useful for treating Progeria.\"<\/p>","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-2130","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts containing a targeted Hutchinson-Gil - The Progeria Research Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.progeriaresearch.org\/ps\/2005\/07\/16\/blocking-proteins\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts containing a targeted Hutchinson-Gil - The Progeria Research Foundation\" \/>\n<meta property=\"og:description\" content=\"[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;3.22&#8243;][et_pb_row _builder_version=&#8221;3.25&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.6.5&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;] Proceedings National Academy of Sciences, July 2005 * By Shao H. Yang, Julia I. Toth, Yan Hu, Salemiz Sandoval, Stephen G. Young, and Loren G. Fong, David Geffen School of Medicine, UCLA; Margarita Meta, University of California, San [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.progeriaresearch.org\/ps\/2005\/07\/16\/blocking-proteins\/\" \/>\n<meta property=\"og:site_name\" content=\"The Progeria Research Foundation\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ProgeriaResearch\/\" \/>\n<meta property=\"article:published_time\" content=\"2005-07-16T20:44:48+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-12-09T16:10:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2011\/05\/1PRFlogo2010_300dpi.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"165\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"gravoc\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@Progeria\" \/>\n<meta name=\"twitter:site\" content=\"@Progeria\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"gravoc\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.progeriaresearch.org\/ko\/2005\/07\/16\/blocking-proteins\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/ko\/2005\/07\/16\/blocking-proteins\/\"},\"author\":{\"name\":\"gravoc\",\"@id\":\"https:\/\/www.progeriaresearch.org\/ta\/#\/schema\/person\/a3c935a81e92242c6a77ae0018542928\"},\"headline\":\"Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts containing a targeted Hutchinson-Gil\",\"datePublished\":\"2005-07-16T20:44:48+00:00\",\"dateModified\":\"2020-12-09T16:10:16+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/ko\/2005\/07\/16\/blocking-proteins\/\"},\"wordCount\":298,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/ta\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/ko\/2005\/07\/16\/blocking-proteins\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2011\/05\/1PRFlogo2010_300dpi.jpg\",\"articleSection\":[\"News\"],\"inLanguage\":\"ps\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.progeriaresearch.org\/ko\/2005\/07\/16\/blocking-proteins\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.progeriaresearch.org\/ko\/2005\/07\/16\/blocking-proteins\/\",\"url\":\"https:\/\/www.progeriaresearch.org\/ko\/2005\/07\/16\/blocking-proteins\/\",\"name\":\"Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts containing a targeted Hutchinson-Gil - 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