[et_pb_section fb_built=\u201d1\u2033 fullwidth=\u201don\u201d disabled_on=\u201doff|off|off\u201d _builder_version=\u201d4.16\u2033 border_width_bottom=\u201d55px\u201d border_color_bottom=\u201d#29327a\u201d global_colors_info=\u201d{}\u201d][et_pb_fullwidth_header _builder_version=\u201d4.16\u2033 title_font_size=\u201d55\u2033 background_color=\u201d#29327a\u201d background_image=\u201dhttps:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/About-Header.jpg\u201d background_position=\u201dcenter_left\u201d custom_padding=\u201d9vw||9vw||true\u201d custom_padding_tablet=\u201d\u201d custom_padding_phone=\u201d|56px||\u201d custom_padding_last_edited=\u201dno|desktop\u201d title_font_size_tablet=\u201d45px\u201d title_font_size_phone=\u201d40px\u201d title_font_size_last_edited=\u201dno|telefone\u201d z_index_tablet=\u201d500\u2033 custom_css_main_element=\u201dposi\u00e7\u00e3o de fundo: centro 18% !importante;\u201d global_colors_info=\u201d{}\u201d]<\/p>\n
[\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=\u201d1\u2033 use_custom_gutter=\u201don\u201d gutter_width=\u201d1\u2033 specialty=\u201don\u201d padding_left_1=\u201d35px\u201d padding_left_2=\u201d35px\u201d padding_2_tablet=\u201d|||0px\u201d padding_2_phone=\u201d|||0px\u201d padding_2_last_edited=\u201don|desktop\u201d module_class_1=\u201dsidebar-secondary-nav\u201d module_class=\u201dhandprint-bg\u201d _builder_version=\u201d4.16\u2033 background_image=\u201dhttps:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/blue-handprint-only.png\u201d parallax=\u201don\u201d parallax_method=\u201doff\u201d largura_interna=\u201d100%\u201d largura_m\u00e1xima_interna=\u201d100%\u201d preenchimento_personalizado=\u201d0|0px|54px|0px|falso|falso\u201d z_index_tablet=\u201d500\u2033 largura_da_borda_superior=\u201d10px\u201d cor_da_borda_superior=\u201d#8fd2ed\u201d use_largura_personalizada=\u201dligado\u201d largura_unit=\u201ddesligado\u201d largura_personalizada_percent=\u201d100%\u201d informa\u00e7\u00f5es_de_cores_globais=\u201d{}\u201d][coluna_et_pb tipo=\u201d1_4\u2033 _builder_version=\u201d4.16\u2033 preenchimento_personalizado=\u201d|||\u201d global_colors_info=\u201d{}\u201d custom_padding__hover=\u201d|||\u201d][et_pb_sidebar area=\u201det_pb_widget_area_18\u2033 disabled_on=\u201don|on|off\u201d module_class=\u201dsubpage-sidebars\u201d _builder_version=\u201d4.16\u2033 animation_style=\u201dfade\u201d z_index_tablet=\u201d500\u2033 border_width_right=\u201d5px\u201d global_colors_info=\u201d{}\u201d]
\n[\/et_pb_sidebar][\/et_pb_column][et_pb_column tipo=\u201d3_4\u2033 colunas_de_especialidade=\u201d3\u2033 _builder_version=\u201d4.16\u2033 preenchimento_personalizado=\u201d|||\u201d global_colors_info=\u201d{}\u201d custom_padding__hover=\u201d|||\u201d][et_pb_row_inner custom_padding_last_edited=\u201don|phone\u201d _builder_version=\u201d4.16\u2033 custom_padding=\u201d39.4375px|35px|35px||false|false\u201d custom_padding_tablet=\u201d|35px||35px||true\u201d custom_padding_phone=\u201d\u201d animation_direction=\u201dtop\u201d global_colors_info=\u201d{}\u201d][et_pb_column_inner saved_specialty_column_type=\u201d3_4\u2033 _builder_version=\u201d4.16\u2033 custom_padding=\u201d|||\u201d global_colors_info=\u201d{}\u201d custom_padding__hover=\u201d|||\u201d][et_pb_text _builder_version=\u201d4.16\u2033 background_size=\u201dinicial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201drepetir\u201d global_colors_info=\u201d{}\u201d]<\/p>\n
Crian\u00e7as com Progeria s\u00e3o geneticamente predispostas a doen\u00e7as card\u00edacas prematuras e progressivas. A morte ocorre quase exclusivamente devido a doen\u00e7as card\u00edacas disseminadas, a principal causa de morte nos EUA e #2 em todo o mundo. Assim como acontece com qualquer pessoa que sofre de doen\u00e7a card\u00edaca, os eventos comuns para crian\u00e7as com Progeria s\u00e3o derrames, press\u00e3o alta, angina, cora\u00e7\u00e3o aumentado e insufici\u00eancia card\u00edaca, todas as condi\u00e7\u00f5es associadas ao envelhecimento.<\/p>\n
[\/et_pb_text][et_pb_testimonial author=\u201dDr. Samer Najjar\u201d job_title=\u201dChefe da Unidade de Estudos Cardiovasculares Humanos\u201d company_name=\u201dInstituto Nacional do Envelhecimento\u201d quote_icon_color=\u201d#00b2e2\u2033 portrait_width=\u201d140px\u201d portrait_height=\u201d140px\u201d admin_label=\u201dCita\u00e7\u00e3o do Dr. Samer Najjar\u201d _builder_version=\u201d4.16\u2033 background_color=\u201d#f7f7f7\u2033 custom_margin=\u201d50px||\u201d custom_margin_tablet=\u201d\u201d custom_margin_phone=\u201d\u201d custom_margin_last_edited=\u201don|desktop\u201d z_index_tablet=\u201d500\u2033 custom_css_testimonial_author=\u201dcor: #00b2e2;||tamanho da fonte: 19px !importante;||peso da fonte: 700;\u201d custom_css_testimonial_meta=\u201destilo da fonte: it\u00e1lico;||peso da fonte: 700;\u201d box_shadow_style_image=\u201dpreset3\u2033 bloqueado=\u201ddesligado\u201d global_colors_info=\u201d{}\u201d]<\/p>\n
\u00a0\u201cEssas crian\u00e7as t\u00eam doen\u00e7as card\u00edacas em um ritmo incrivelmente acelerado, geralmente quando t\u00eam 12, 13 ou 14 anos. Na comunidade em geral, a preval\u00eancia de doen\u00e7as cardiovasculares come\u00e7a a aparecer nas d\u00e9cadas de 60 e 70. Obviamente, h\u00e1 algum processo que \u00e9 acelerado.\u201d<\/p>\n
[\/et_pb_testimonial][et_pb_text _builder_version=\u201d4.16\u2033 background_size=\u201dinicial\u201d background_position=\u201dtopo_esquerdo\u201d background_repeat=\u201drepetir\u201d global_colors_info=\u201d{}\u201d]<\/p>\n
Portanto, h\u00e1 claramente uma tremenda necessidade de pesquisa em Prog\u00e9ria. Porque encontrar uma cura para a Prog\u00e9ria n\u00e3o s\u00f3 ajudar\u00e1 essas crian\u00e7as, mas pode fornecer chaves para o tratamento de milh\u00f5es de adultos com doen\u00e7as card\u00edacas e derrames associados ao processo natural de envelhecimento<\/em>.<\/p>\n Clique aqui para saber mais sobre a pesquisa que sugere uma liga\u00e7\u00e3o entre a Prog\u00e9ria e o envelhecimento normal.\u00a0<\/a><\/p>\n [\/et_pb_text][et_pb_text _builder_version=\u201d4.16\u2033 background_size=\u201dinicial\u201d background_position=\u201dsuperior_esquerdo\u201d background_repeat=\u201drepetir\u201d global_colors_info=\u201d{}\u201d]<\/p>\n <\/p>\n Como o processo de envelhecimento \u00e9 acelerado em crian\u00e7as com Prog\u00e9ria, eles oferecem aos pesquisadores uma rara oportunidade de observar em apenas alguns anos o que, de outra forma, exigiria d\u00e9cadas de estudos longitudinais.<\/p>\n [\/et_pb_text][et_pb_testimonial author=\u201dDr. Huber Warner\u201d job_title=\u201dDiretor Associado\u201d company_name=\u201dInstituto Nacional do Envelhecimento\u201d quote_icon_color=\u201d#00b2e2\u2033 portrait_width=\u201d140px\u201d portrait_height=\u201d140px\u201d admin_label=\u201dCita\u00e7\u00e3o do Dr. Huber Warner\u201d _builder_version=\u201d4.16\u2033 background_color=\u201d#f7f7f7\u2033 custom_margin=\u201d50px||\u201d custom_margin_tablet=\u201d\u201d custom_margin_phone=\u201d\u201d custom_margin_last_edited=\u201don|desktop\u201d z_index_tablet=\u201d500\u2033 custom_css_testimonial_author=\u201dcor: #00b2e2;||tamanho da fonte: 19px !importante;||peso da fonte: 700;\u201d custom_css_testimonial_meta=\u201destilo da fonte: it\u00e1lico;||peso da fonte: 700;\u201d box_shadow_style_image=\u201dpreset3\u2033 bloqueado=\u201ddesligado\u201d global_colors_info=\u201d{}\u201d]<\/p>\n \u201cUma melhor compreens\u00e3o das causas desta s\u00edndrome (Prog\u00e9ria) pode levar a melhores percep\u00e7\u00f5es sobre os mecanismos de desenvolvimento e envelhecimento.\u201d\u00a0<\/p>\n [\/et_pb_testimonial][et_pb_testimonial author=\u201dDr. Vilhelm Bohr\u201d job_title=\u201dPresidente de Gerontologia Molecular\u201d company_name=\u201dInstituto Nacional do Envelhecimento\u201d quote_icon_color=\u201d#00b2e2\u2033 portrait_width=\u201d140px\u201d portrait_height=\u201d140px\u201d admin_label=\u201dCita\u00e7\u00e3o do Dr. Vilhelm Bohr\u201d _builder_version=\u201d4.16\u2033 background_color=\u201d#f7f7f7\u2033 custom_margin=\u201d50px||\u201d custom_margin_tablet=\u201d\u201d custom_margin_phone=\u201d\u201d custom_margin_last_edited=\u201don|desktop\u201d z_index_tablet=\u201d500\u2033 custom_css_testimonial_author=\u201dcor: #00b2e2;||tamanho da fonte: 19px !importante;||peso da fonte: 700;\u201d custom_css_testimonial_meta=\u201destilo da fonte: it\u00e1lico;||peso da fonte: 700;\u201d box_shadow_style_image=\u201dpreset3\u2033 bloqueado=\u201ddesligado\u201d global_colors_info=\u201d{}\u201d]<\/p>\n \u201c\u00c9 incr\u00edvel o quanto a Progeria se assemelha ao processo normal de envelhecimento. Acho que essas prote\u00ednas ligadas \u00e0 Progeria desempenham um papel muito profundo no processo de envelhecimento, e acho que j\u00e1 vimos algumas descobertas bem grandes em termos do que essas prote\u00ednas fazem.\u201d<\/p>\n [\/et_pb_testimonial][et_pb_text _builder_version=\u201d4.16\u2033 background_size=\u201dinicial\u201d background_position=\u201dtopo_esquerdo\u201d background_repeat=\u201drepetir\u201d global_colors_info=\u201d{}\u201d]<\/p>\n <\/p>\n Crian\u00e7as com Prog\u00e9ria tamb\u00e9m desenvolvem e morrem de aterosclerose e arteriosclerose (comumente chamadas de doen\u00e7as card\u00edacas). A aterosclerose \u00e9 apenas um dos v\u00e1rios tipos de \u201carterio\u201d-esclerose, que \u00e9 caracterizada pelo espessamento e endurecimento das art\u00e9rias, mas os dois termos s\u00e3o frequentemente usados para significar a mesma coisa. Algum endurecimento das art\u00e9rias frequentemente ocorre quando as pessoas envelhecem.<\/p>\n A aterosclerose envolve dep\u00f3sitos de subst\u00e2ncias gordurosas no revestimento interno de uma art\u00e9ria. Esse ac\u00famulo \u00e9 chamado de placa. As placas podem crescer o suficiente para reduzir significativamente o fluxo de sangue atrav\u00e9s de uma art\u00e9ria, ou as placas se tornam fr\u00e1geis e se rompem para formar co\u00e1gulos que podem bloquear o fluxo sangu\u00edneo. Se o bloqueio ocorrer em uma art\u00e9ria que alimenta o cora\u00e7\u00e3o, isso causa uma ataque card\u00edaco<\/em>. Se o bloqueio ocorrer em uma art\u00e9ria que alimenta o c\u00e9rebro, isso causa uma AVC<\/em>. A aterosclerose n\u00e3o \u00e9 apenas a causa de morte entre crian\u00e7as com Prog\u00e9ria, mas tamb\u00e9m a principal causa de morte nos Estados Unidos e em muitas outras partes do mundo em indiv\u00edduos com envelhecimento normal<\/em>. Esperamos que a descoberta do gene Progeria tenha um efeito ben\u00e9fico n\u00e3o apenas para os pacientes com Progeria, mas tamb\u00e9m para os milh\u00f5es de pessoas afetadas por condi\u00e7\u00f5es relacionadas ao envelhecimento, incluindo ataques card\u00edacos e derrames causados por aterosclerose e arteriosclerose.<\/p>\n [\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][\/et_pb_section][et_pb_section fb_built=\u201d1\u2033 module_class=\u201drodap\u00e9\u201d _builder_version=\u201d4.21.0\u2033 background_color=\u201d#29327a\u201d custom_margin=\u201d-2px|||||\u201d custom_padding=\u201d0|0px|0|0px|false|false\u201d z_index_tablet=\u201d500\u2033 border_width_top=\u201d12px\u201d border_color_top=\u201d#00b2e2\u2033 global_module=\u201d133\u2033 locked=\u201doff\u201d global_colors_info=\u201d{}\u201d][et_pb_row column_structure=\u201d1_4,1_4,1_2\u2033 make_equal=\u201don\u201d module_class=\u201d et_pb_row_fullwidth\u201d 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2023 5\u2033 _builder_version=\u201d4.21.0\u2033 _module_preset=\u201ddefault\u201d custom_margin=\u201d35px||||false|false\u201d global_colors_info=\u201d{}\u201d][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":" [et_pb_section fb_built=\u201d1\u2033 fullwidth=\u201don\u201d disabled_on=\u201doff|off|off\u201d _builder_version=\u201d4.16\u2033 border_width_bottom=\u201d55px\u201d border_color_bottom=\u201d#29327a\u201d global_colors_info=\u201d{}\u201d][et_pb_fullwidth_header _builder_version=\u201d4.16\u2033 title_font_size=\u201d55\u2033 background_color=\u201d#29327a\u201d background_image=\u201dhttps:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/About-Header.jpg\u201d background_position=\u201dcenter_left\u201d custom_padding=\u201d9vw||9vw||true\u201d custom_padding_tablet=\u201d\u201d custom_padding_phone=\u201d|56px||\u201d custom_padding_last_edited=\u201dno|desktop\u201d 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Inscrever-se<\/h2>\n
para o nosso<\/h2>\n
Boletim informativo!<\/h2>\n
Juntos, n\u00f3s<\/h2>\n
VAI<\/em><\/h2>\n
encontre a cura!<\/h2>\n
Aging<\/h1>\r\nChildren with Progeria are genetically predisposed to premature, progressive heart disease. Death occurs almost exclusively due to widespread heart disease, the leading cause of death in the US, and #2 worldwide. As with any person suffering from heart disease, the common events for Progeria children are strokes, high blood pressure, angina, enlarged heart, and heart failure, all conditions associated with aging.[\/vc_column_text][vc_column_text]\"These children get heart disease at an incredibly accelerated pace, usually by the time they are 12, 13 or 14. In the general community, the prevalence of cardiovascular disease starts appearing in the 60s and 70s. Obviously, there's some process that's accelerated.\"\r\n\r\n\u2014 Dr. Samer Najjar, head of the Human Cardiovascular Studies Unit at the National Institute on Aging[\/vc_column_text][vc_column_text]Thus there is clearly a tremendous need for research in Progeria. Because finding a cure for Progeria will not only help these children, but may provide keys for treating millions of adults with heart disease and stroke associated with the natural aging process<\/em>.\r\n\r\nBecause the aging process is accelerated in children with Progeria, they offer researchers a rare opportunity to observe in just a few years what would otherwise require decades of longitudinal studies.\r\n\r\n\"A better understanding of the causes of this syndrome (Progeria) could lead to better insights into the mechanisms of both development and aging.\" - National Institute of Aging Associate Director Dr. Huber Warner\r\n\r\nClick here to find out more about the research that suggests a link between Progeria and normal aging<\/a>[\/vc_column_text][vc_column_text]\"It's amazing how much Progeria resembles the normal aging process. I think these proteins linked to Progeria play a very profound role in the aging process, and I think we've already seen some pretty big findings in terms of what these proteins do.\r\n\r\n\u2014 Dr. Vilhelm Bohr, chairman of molecular gerontology at the National Institute on Aging[\/vc_column_text][vc_column_text]\r\n
Atherosclerosis<\/h1>\r\nChildren with Progeria also develop and die of atherosclerosis and arteriosclerosis (commonly referred to as heart disease). Atherosclerosis is just one of several types of \"arterio\"-sclerosis, which is characterized by thickening and hardening of the arteries, but the two terms are often used to mean the same thing. Some hardening of the arteries often occurs when people grow older.\r\n\r\nAtherosclerosis involves deposits of fatty substances in the inner lining of an artery. This buildup is called plaque. Plaques can grow large enough to significantly reduce the flow of blood through an artery, or plaques become fragile and rupture to form clots that can block blood flow. If the blockage occurs to an artery that feeds into the heart, it causes a heart attack<\/em>. If the blockage occurs to an artery that feeds into the brain, it causes a stroke<\/em>. Atherosclerosis is not only the cause of death among children with Progeria, but also the leading cause of death in the United States and many other parts of the world in normal aging individuals<\/em>. It is our hope that the discovery of the Progeria gene will have a beneficial effect not only for Progeria patients, but also for the millions of people affected by aging-related conditions, including heart attacks and stroke caused by atherosclerosis and arteriosclerosis.[\/vc_column_text][\/vc_column][\/vc_row]\t\t","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-770","page","type-page","status-publish","hentry"],"yoast_head":"\n