{"id":2047,"date":"2011-05-16T12:31:46","date_gmt":"2011-05-16T12:31:46","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?p=2047"},"modified":"2020-12-10T17:54:48","modified_gmt":"2020-12-10T22:54:48","slug":"groundbreaking-study-on-progeria-aging-link","status":"publish","type":"post","link":"https:\/\/www.progeriaresearch.org\/pt\/2011\/05\/16\/groundbreaking-study-on-progeria-aging-link\/","title":{"rendered":"Estudo inovador sobre a rela\u00e7\u00e3o entre progeria e envelhecimento"},"content":{"rendered":"<p>[et_pb_section fb_built=\u201d1\u2033 _builder_version=\u201d3.22\u2033][et_pb_row _builder_version=\u201d3.25\u2033 background_size=\u201dinicial\u201d background_position=\u201dtopo_esquerdo\u201d background_repeat=\u201drepetir\u201d][et_pb_column type=\u201d4_4\u2033 _builder_version=\u201d3.25\u2033 custom_padding=\u201d|||\u201d custom_padding__hover=\u201d|||\u201d][et_pb_text _builder_version=\u201d4.6.5\u2033 background_size=\u201dinicial\u201d background_position=\u201dtopo_esquerdo\u201d background_repeat=\u201drepetir\u201d hover_enabled=\u201d0\u2033 sticky_enabled=\u201d0\u2033]<\/p>\n<p>A conex\u00e3o cativante entre Prog\u00e9ria e envelhecimento continua a se fortalecer, \u00e0 medida que pesquisadores do NIH descobrem liga\u00e7\u00e3o entre tel\u00f4meros e progerina.<\/p>\n<p class=\"yiv314624100msonormal\"><a href=\"https:\/\/www.cbsnews.com\/news\/clues-about-how-we-age-found-in-genetic-disorder\/\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-2052\" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2017\/05\/Capture.png\" alt=\"\" width=\"427\" height=\"279\" srcset=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2017\/05\/Capture.png 427w, https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2017\/05\/Capture-300x196.png 300w\" sizes=\"(max-width: 427px) 100vw, 427px\" \/><\/a>Pesquisadores do National Institutes of Health descobriram uma liga\u00e7\u00e3o at\u00e9 ent\u00e3o desconhecida entre Progeria e envelhecimento. As descobertas fornecem insights sobre a rela\u00e7\u00e3o entre a prote\u00edna t\u00f3xica causadora da Progeria conhecida como <strong>progerina <\/strong>e <strong>tel\u00f4meros<\/strong>, que protegem as extremidades do DNA dentro das c\u00e9lulas at\u00e9 que elas se desgastem com o tempo e as c\u00e9lulas morram.<\/p>\n<p class=\"yiv314624100msonormal\">O estudo* aparece na edi\u00e7\u00e3o online antecipada de 13 de junho de 2011 do Journal of Clinical Investigation. Ele conclui que no envelhecimento normal, tel\u00f4meros curtos ou disfuncionais estimulam as c\u00e9lulas a produzir progerina, que est\u00e1 associada a danos celulares relacionados \u00e0 idade.<\/p>\n<div id=\"attachment_2048\" style=\"width: 410px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-2048\" class=\"wp-image-2048 size-full\" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2017\/05\/panel.jpg\" alt=\"\" width=\"400\" height=\"159\" srcset=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2017\/05\/panel.jpg 400w, https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2017\/05\/panel-300x119.jpg 300w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><p id=\"caption-attachment-2048\" class=\"wp-caption-text\">C\u00e9lulas que expressam progerina de indiv\u00edduos normais mostram sinais de senesc\u00eancia. O DNA no n\u00facleo \u00e9 corado de azul. Tel\u00f4meros s\u00e3o vistos como pontos vermelhos.<\/p><\/div>\n<p class=\"yiv314624100msonormal\">\u201c<strong>Pela primeira vez, sabemos que o encurtamento e a disfun\u00e7\u00e3o do tel\u00f4mero influenciam a produ\u00e7\u00e3o de progerina\u201d, diz a diretora m\u00e9dica da Progeria Research Foundation, Leslie B. Gordon, MD, PhD. \u201cPortanto, esses dois processos, ambos influenciando o envelhecimento celular, est\u00e3o realmente ligados.\u201d<\/strong><\/p>\n<p class=\"yiv314624100msonormal\">Pesquisas anteriores mostraram que a progerina n\u00e3o \u00e9 produzida apenas em crian\u00e7as com Progeria, mas que \u00e9 produzida em quantidades menores em todos n\u00f3s, e os n\u00edveis de progerina aumentam com o envelhecimento. Independentemente, pesquisas anteriores sobre encurtamento e disfun\u00e7\u00e3o de tel\u00f4meros foram associadas ao envelhecimento normal. Desde 2003, com a descoberta da muta\u00e7\u00e3o do gene Progeria e da prote\u00edna progerina que causa a doen\u00e7a, uma das principais \u00e1reas de pesquisa se concentrou em entender se e como a Progeria e o envelhecimento est\u00e3o ligados.<\/p>\n<p class=\"yiv314624100msonormal\">\u201cConectar esse fen\u00f4meno de doen\u00e7a rara e envelhecimento normal est\u00e1 dando frutos de uma forma importante\u201d, disse o diretor do NIH Francis S. Collins, MD, PhD, um autor s\u00eanior do artigo. \u201cEste estudo destaca que insights biol\u00f3gicos valiosos s\u00e3o obtidos ao estudar dist\u00farbios gen\u00e9ticos raros como a Progeria. Nossa sensa\u00e7\u00e3o desde o in\u00edcio foi que a Progeria tinha muito a nos ensinar sobre o processo normal de envelhecimento. \u201c<\/p>\n<p class=\"yiv314624100msoplaintext\">Cientistas tradicionalmente estudam tel\u00f4meros e progerina separadamente. Embora ainda haja muito a aprender sobre se essa nova conex\u00e3o pode levar \u00e0 cura de crian\u00e7as com Progeria ou potencialmente ser aplicada para estender a expectativa de vida humana, este estudo fornece mais evid\u00eancias de que a progerina, a prote\u00edna t\u00f3xica descoberta por meio da descoberta da muta\u00e7\u00e3o gen\u00e9tica na Progeria, desempenha um papel no processo normal de envelhecimento.<\/p>\n<p class=\"yiv314624100msoplaintext justifyleft\">*<em>Progerina e disfun\u00e7\u00e3o do tel\u00f4mero colaboram para desencadear senesc\u00eancia celular em fibroblastos humanos normais<\/em>, Cao e outros, <em>J Clin Invest <\/em>doi:10.1172\/JCI43578.<\/p>\n<p class=\"yiv314624100msoplaintext\"><a href=\"https:\/\/www.progeriaresearch.org\/pt\/assets\/files\/pdf\/psa_ads\/NIH%20Press%20Release.pdf\/\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/web.archive.org\/web\/20170216015614im_\/https:\/\/www.progeriaresearch.org\/assets\/images\/iconPDF.gif\" alt=\"\" width=\"34\" height=\"20\" \/>Clique aqui<\/a> para o texto completo do comunicado de imprensa do NIH.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"<p>[et_pb_section fb_built=\u201d1\u2033 _builder_version=\u201d3.22\u2033][et_pb_row _builder_version=\u201d3.25\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201drepeat\u201d][et_pb_column type=\u201d4_4\u2033 _builder_version=\u201d3.25\u2033 custom_padding=\u201d|||\u201d A fascinante conex\u00e3o entre a Progeria e o envelhecimento continua a se fortalecer, \u00e0 medida que pesquisadores do NIH descobrem uma liga\u00e7\u00e3o entre tel\u00f4meros e progerina. Pesquisadores dos Institutos Nacionais de Sa\u00fade (NIH) descobriram uma liga\u00e7\u00e3o at\u00e9 ent\u00e3o desconhecida entre a Progeria e o envelhecimento. As descobertas fornecem informa\u00e7\u00f5es importantes [\u2026]<\/p>","protected":false},"author":1,"featured_media":2048,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"<p>[vc_custom_heading text=\"Groundbreaking Study on Progeria-Aging Link\" font_container=\"tag:h1|text_align:left\" use_theme_fonts=\"yes\"]<\/p><div id=\"secondary-header-content\"><p>The captivating connection between Progeria and aging continues to strengthen, as NIH researchers find link between telomeres and progerin.<\/p><\/div><p class=\"yiv314624100msonormal\"><a href=\"https:\/\/www.cbsnews.com\/news\/clues-about-how-we-age-found-in-genetic-disorder\/\"><img class=\"aligncenter size-full wp-image-2052\" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2017\/05\/Capture.png\" alt=\"\" width=\"427\" height=\"279\" \/><\/a>National Institutes of Health researchers have discovered a previously unknown link between Progeria and aging.\u00a0 The findings provide insights about the relationship between the toxic, Progeria-causing protein known as <strong>progerin <\/strong>and <strong>telomeres<\/strong>, which protect the ends of DNA within cells until they wear away over time and the cells die.<\/p><p class=\"yiv314624100msonormal\">The study* appears in the June 13, 2011 early online edition of the Journal of Clinical Investigation. It concludes that in normal aging, short or dysfunctional telomeres stimulate cells to produce progerin, which is associated with age-related cell damage.<\/p>[caption id=\"attachment_2048\" align=\"aligncenter\" width=\"400\"]<img class=\"wp-image-2048 size-full\" src=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2017\/05\/panel.jpg\" alt=\"\" width=\"400\" height=\"159\" \/> Progerin-expressing cells from normal individuals show signs of senescence. DNA in the nucleus is stained blue. Telomeres are seen as red dots.[\/caption]<p class=\"yiv314624100msonormal\">\"<strong>For the first time, we know that telomere shortening and dysfunction influences the production of progerin,\" says The Progeria Research Foundation Medical Director Leslie B. Gordon, MD, PhD. \"Thus these two processes, both of which influence cellular aging, are actually linked.\"<\/strong><\/p><p class=\"yiv314624100msonormal\">Prior research has shown that progerin is not only produced in children with Progeria, but that it is produced in smaller amounts in all of us, and progerin levels increase with aging. Independently, previous research on telomere shortening and dysfunction has been associated with normal aging. Since 2003, with the discovery of the Progeria gene mutation and the progerin protein that causes the disease, one of the key areas of research has focused on understanding whether and how Progeria and aging are linked.<\/p><p class=\"yiv314624100msonormal\">\"Connecting this rare disease phenomenon and normal aging is bearing fruit in an important way,\" said NIH Director Francis S. Collins, MD, PhD, a senior author of the paper. \"This study highlights that valuable biological insights are gained by studying rare genetic disorders such as Progeria. Our sense from the start was that Progeria had a lot to teach us about the normal aging process. \"<\/p><p class=\"yiv314624100msoplaintext\">Scientists have traditionally studied telomeres and progerin separately. While there is still much to learn about whether this new connection can lead to a cure for children with Progeria or potentially be applied to extending the human lifespan, this study provides further evidence that progerin, the toxic protein discovered through finding the gene mutation in Progeria, plays a role in the normal aging process.<\/p><p class=\"yiv314624100msoplaintext justifyleft\">*<em>Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts<\/em>, Cao et al, <em>J Clin Invest <\/em>doi:10.1172\/JCI43578.<\/p><p class=\"yiv314624100msoplaintext\"><a href=\"https:\/\/www.progeriaresearch.org\/assets\/files\/pdf\/psa_ads\/NIH%20Press%20Release.pdf\"><img src=\"https:\/\/web.archive.org\/web\/20170216015614im_\/https:\/\/www.progeriaresearch.org\/assets\/images\/iconPDF.gif\" alt=\"\" width=\"34\" height=\"20\" \/>Click here<\/a> for the full text of the NIH press release.<\/p>","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-2047","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Groundbreaking Study on Progeria-Aging Link - The Progeria Research Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.progeriaresearch.org\/pt\/2011\/05\/16\/groundbreaking-study-on-progeria-aging-link\/\" \/>\n<meta property=\"og:locale\" content=\"pt_PT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Groundbreaking Study on Progeria-Aging Link - The Progeria Research Foundation\" \/>\n<meta property=\"og:description\" content=\"[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;3.22&#8243;][et_pb_row _builder_version=&#8221;3.25&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.6.5&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;] The captivating connection between Progeria and aging continues to strengthen, as NIH researchers find link between telomeres and progerin. National Institutes of Health researchers have discovered a previously unknown link between Progeria and aging.\u00a0 The findings provide insights [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.progeriaresearch.org\/pt\/2011\/05\/16\/groundbreaking-study-on-progeria-aging-link\/\" \/>\n<meta property=\"og:site_name\" content=\"The Progeria Research Foundation\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ProgeriaResearch\/\" \/>\n<meta property=\"article:published_time\" content=\"2011-05-16T12:31:46+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-12-10T22:54:48+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2017\/05\/panel.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"159\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"gravoc\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@Progeria\" \/>\n<meta name=\"twitter:site\" content=\"@Progeria\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"gravoc\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.progeriaresearch.org\/ur\/2011\/05\/16\/groundbreaking-study-on-progeria-aging-link\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/ur\/2011\/05\/16\/groundbreaking-study-on-progeria-aging-link\/\"},\"author\":{\"name\":\"gravoc\",\"@id\":\"https:\/\/www.progeriaresearch.org\/ta\/#\/schema\/person\/a3c935a81e92242c6a77ae0018542928\"},\"headline\":\"Groundbreaking Study on Progeria-Aging Link\",\"datePublished\":\"2011-05-16T12:31:46+00:00\",\"dateModified\":\"2020-12-10T22:54:48+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/ur\/2011\/05\/16\/groundbreaking-study-on-progeria-aging-link\/\"},\"wordCount\":488,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/ta\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/ur\/2011\/05\/16\/groundbreaking-study-on-progeria-aging-link\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2017\/05\/panel.jpg\",\"articleSection\":[\"News\"],\"inLanguage\":\"pt-PT\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.progeriaresearch.org\/ur\/2011\/05\/16\/groundbreaking-study-on-progeria-aging-link\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.progeriaresearch.org\/ur\/2011\/05\/16\/groundbreaking-study-on-progeria-aging-link\/\",\"url\":\"https:\/\/www.progeriaresearch.org\/ur\/2011\/05\/16\/groundbreaking-study-on-progeria-aging-link\/\",\"name\":\"Groundbreaking Study on Progeria-Aging Link - 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Funda\u00e7\u00e3o de Pesquisa da Progeria","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.progeriaresearch.org\/pt\/2011\/05\/16\/groundbreaking-study-on-progeria-aging-link\/","og_locale":"pt_PT","og_type":"article","og_title":"Groundbreaking Study on Progeria-Aging Link - The Progeria Research Foundation","og_description":"[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;3.22&#8243;][et_pb_row _builder_version=&#8221;3.25&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.6.5&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;] The captivating connection between Progeria and aging continues to strengthen, as NIH researchers find link between telomeres and progerin. 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