{"id":2107,"date":"2006-05-16T20:16:46","date_gmt":"2006-05-16T20:16:46","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?p=2107"},"modified":"2020-12-09T15:32:43","modified_gmt":"2020-12-09T20:32:43","slug":"prf-funded-studies-provide-support-for-drug-trial","status":"publish","type":"post","link":"https:\/\/www.progeriaresearch.org\/pt\/2006\/05\/16\/prf-funded-studies-provide-support-for-drug-trial\/","title":{"rendered":"Estudos financiados pela PRF fornecem suporte para testes de medicamentos"},"content":{"rendered":"

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PRF atinge $1,4 dos $2 milh\u00f5es necess\u00e1rios para financiar o teste!<\/u> Em julho, os pesquisadores da UCLA Loren Fong e Stephen Young publicaram descobertas de estudos financiados pela PRF com camundongos Progeria, testando um potencial tratamento medicamentoso para crian\u00e7as com Progeria. O medicamento FTI melhorou alguns sinais da doen\u00e7a nos camundongos! Esses e outros estudos recentes abriram caminho para a PRF come\u00e7ar um ensaio cl\u00ednico com as crian\u00e7as. Junte-se ao nosso Campanha de Ensaios Cl\u00ednicos<\/a> e ajude a fazer o julgamento acontecer!<\/p>\n

\"\"20 de julho de 2006: Pesquisadores financiados pela PRF continuam a impulsionar a pesquisa sobre Progeria para novos n\u00edveis de progresso em nossa busca pela cura. Publicado na edi\u00e7\u00e3o online de hoje do Revista de Investiga\u00e7\u00e3o Cl\u00ednica<\/em>, as descobertas apoiam o in\u00edcio de ensaios cl\u00ednicos em humanos com o medicamento contra o c\u00e2ncer, inibidor da farnesiltransferase (FTI).<\/div>\n
\u00a0<\/div>\n
A PRF est\u00e1 financiando um ensaio cl\u00ednico de medicamento para Progeria<\/a><\/u>, que come\u00e7ou em 7 de maio. O teste est\u00e1 tratando as crian\u00e7as com um medicamento chamado FTI. Este \u00e9 um momento cr\u00edtico para ajudar a PRF, pois estamos arrecadando dinheiro para financiar o teste.<\/div>\n
Clique aqui<\/a> para descobrir como voc\u00ea pode ajudar.<\/div>\n
\u00a0<\/div>\n
Trechos retirados do Revista de Investiga\u00e7\u00e3o Cl\u00ednica:<\/em><\/div>\n
\u00a0<\/div>\n
Medicamento contra c\u00e2ncer melhora a progeria: novo modelo de camundongo mais pr\u00f3ximo da doen\u00e7a em humanos<\/u><\/strong><\/div>\n
\u00a0<\/div>\n
Usando seu novo modelo de camundongo de progeria, os investigadores da UCLA descobriram que um medicamento experimental, chamado inibidor de farnesiltransferase, melhorou a densidade \u00f3ssea, reduziu fraturas \u00f3sseas, atrasou o in\u00edcio da doen\u00e7a e ajudou no ganho de peso. Os efeitos do medicamento foram mais dram\u00e1ticos do que em estudos anteriores usando outros modelos animais. Este novo modelo de camundongo espelha de perto o defeito gen\u00e9tico que causa muitos casos de progeria em humanos.<\/div>\n
Essas descobertas ajudar\u00e3o os pesquisadores a direcionar terapias medicamentosas para crian\u00e7as com progeria e levar\u00e3o a uma melhor compreens\u00e3o dos mecanismos da doen\u00e7a. As descobertas da UCLA tornaram vi\u00e1vel considerar ensaios cl\u00ednicos em humanos.<\/div>\n
\u00a0<\/div>\n
Os pesquisadores da UCLA incluem o Dr. Shao H. Yang, Loren G. Fong, Ph.D., e o Dr. Stephen G. Young da Escola de Medicina David Geffen da UCLA.<\/div>\n

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[et_pb_section fb_built=\u201d1\u2033 _builder_version=\u201d3.22\u2033][et_pb_row _builder_version=\u201d3.25\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201drepeat\u201d][et_pb_column type=\u201d4_4\u2033 _builder_version=\u201d3.25\u2033 custom_padding=\u201d|||\u201d custom_padding__hover=\u201d|||\u201d][et_pb_text _builder_version=\u201d4.6.5\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201drepeat\u201d hover_enabled=\u201d0\u2033 sticky_enabled=\u201d0\u2033] A PRF alcan\u00e7ou 1,4 milh\u00e3o dos 2 milh\u00f5es necess\u00e1rios para financiar o ensaio cl\u00ednico! Em julho, os pesquisadores da UCLA, Loren Fong e Stephen Young, publicaram resultados de estudos financiados pela PRF com camundongos com progeria, testando um poss\u00edvel tratamento medicamentoso para crian\u00e7as com progeria. O [\u2026]<\/p>","protected":false},"author":1,"featured_media":2108,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"

[vc_custom_heading text=\"PRF-Funded Studies Provide Support for Drug Trial\" font_container=\"tag:h1|text_align:left\" use_theme_fonts=\"yes\"]<\/p>

PRF Reaches $1.4 of the $2 Million Needed to Fund Trial!<\/u> In July, UCLA researchers Loren Fong and Stephen Young published findings from PRF-funded studies with Progeria mice, testing a potential drug treatment for children with Progeria. The FTI drug improved some signs of the disease in the mice! These and other recent studies have paved the way for PRF to begin a clinical trial with the children. Join our Clinical Trial Campaign<\/a> and help make the trial happen!<\/p><\/div>

\"\"July 20, 2006:\u00a0 PRF-funded researchers continue to drive Progeria research to new levels of progress in our quest for the cure.\u00a0Published in today's online edition of the Journal of Clinical Investigation<\/em>, the findings support the start of human clinical trials with the cancer drug, farnesyltransferase inhibitor (FTI).<\/div>
\u00a0<\/div>
PRF is funding a clinical drug trial for Progeria<\/a><\/u>, which began on May 7th. The trial is treating the children with a drug called FTI. This is a critical time to help PRF, as we are raising money to fund the trial.<\/div>
Click here<\/a> to find out how you can help.<\/div>
\u00a0<\/div>
Excerpts taken from the Journal of Clinical Investigation:<\/em><\/div>
\u00a0<\/div>
Cancer Drug Improves Progeria: New Mouse Model Closest to Disease in Humans<\/u><\/strong><\/div>
\u00a0<\/div>
Using their new mouse model of progeria, UCLA Investigators found that an experimental drug, called a farnesyltransferase inhibitor, improved bone density, reduced bone fractures, delayed the onset of the disease, and helped with weight gain. The effects of the drug were more dramatic than in previous studies using other animal models. This new mouse model closely mirrors the genetic defect causing many cases of progeria in humans.<\/div>
These findings will help researchers target drug therapies for children with progeria and lead to a better understanding of mechanisms of disease. The UCLA findings have made it feasible to consider human clinical trials.<\/div>
\u00a0<\/div>
UCLA researchers include Dr. Shao H. Yang, Loren G. Fong, Ph.D., and Dr. Stephen G. Young of the David Geffen School of Medicine at UCLA.<\/div>","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-2107","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"yoast_head":"\nPRF-Funded Studies Provide Support for Drug Trial - The Progeria Research Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.progeriaresearch.org\/pt\/2006\/05\/16\/prf-funded-studies-provide-support-for-drug-trial\/\" \/>\n<meta property=\"og:locale\" content=\"pt_PT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PRF-Funded Studies Provide Support for Drug Trial - The Progeria Research Foundation\" \/>\n<meta property=\"og:description\" content=\"[et_pb_section fb_built=”1″ _builder_version=”3.22″][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.6.5″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” hover_enabled=”0″ sticky_enabled=”0″] PRF Reaches $1.4 of the $2 Million Needed to Fund Trial! In July, UCLA researchers Loren Fong and Stephen Young published findings from PRF-funded studies with Progeria mice, testing a potential drug treatment for children with Progeria. 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Funda\u00e7\u00e3o de Pesquisa da Progeria","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.progeriaresearch.org\/pt\/2006\/05\/16\/prf-funded-studies-provide-support-for-drug-trial\/","og_locale":"pt_PT","og_type":"article","og_title":"PRF-Funded Studies Provide Support for Drug Trial - The Progeria Research Foundation","og_description":"[et_pb_section fb_built=”1″ _builder_version=”3.22″][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.6.5″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” hover_enabled=”0″ sticky_enabled=”0″] PRF Reaches $1.4 of the $2 Million Needed to Fund Trial! In July, UCLA researchers Loren Fong and Stephen Young published findings from PRF-funded studies with Progeria mice, testing a potential drug treatment for children with Progeria. 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