{"id":2113,"date":"2006-02-16T20:28:04","date_gmt":"2006-02-16T20:28:04","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?p=2113"},"modified":"2020-12-09T11:16:33","modified_gmt":"2020-12-09T16:16:33","slug":"three-studies-released-that-bring-us-closer-than-ever-to-understanding-progeria-and-to-disease-treatment","status":"publish","type":"post","link":"https:\/\/www.progeriaresearch.org\/pt\/2006\/02\/16\/three-studies-released-that-bring-us-closer-than-ever-to-understanding-progeria-and-to-disease-treatment\/","title":{"rendered":"Tr\u00eas estudos divulgados que nos aproximam mais do que nunca da compreens\u00e3o da Prog\u00e9ria e do tratamento da doen\u00e7a"},"content":{"rendered":"

[et_pb_section fb_built=\u201d1\u2033 _builder_version=\u201d3.22\u2033][et_pb_row _builder_version=\u201d3.25\u2033 background_size=\u201dinicial\u201d background_position=\u201dtopo_esquerdo\u201d background_repeat=\u201drepetir\u201d][et_pb_column type=\u201d4_4\u2033 _builder_version=\u201d3.25\u2033 custom_padding=\u201d|||\u201d custom_padding__hover=\u201d|||\u201d][et_pb_text _builder_version=\u201d4.6.5\u2033 background_size=\u201dinicial\u201d background_position=\u201dtopo_esquerdo\u201d background_repeat=\u201drepetir\u201d hover_enabled=\u201d0\u2033 sticky_enabled=\u201d0\u2033]<\/p>\n

Pesquisadores da UCLA financiados pela PRF pegaram um modelo de camundongo semelhante \u00e0 Progeria e testaram um potencial tratamento medicamentoso para crian\u00e7as com Progeria. O estudo deles divulgado na Science em 16 de fevereiro descobriu que esse medicamento FTI melhora alguns sinais da doen\u00e7a.<\/p>\n

Em setembro, a Progeria Research Foundation teve o prazer de anunciar que pesquisadores financiados pela PRF publicaram estudos apoiando um potencial tratamento medicamentoso para crian\u00e7as com Progeria \u2013 c\u00e9lulas de Progeria se normalizaram (em uma placa) quando receberam este medicamento. A pr\u00f3xima fase de testes foi em modelos animais, e estamos animados em relatar que um estudo divulgado na Science em 16 de fevereiro descobriu que este medicamento FTI melhora alguns sinais da doen\u00e7a em um modelo de camundongo semelhante \u00e0 progeria. A PRF ajudou a financiar os pesquisadores da UCLA, Dr. Loren Fong e Dr. Stephen Young, para este \u00faltimo e vital passo em dire\u00e7\u00e3o aos ensaios cl\u00ednicos de tratamento com as crian\u00e7as. Clique aqui para mais detalhes<\/a> sobre esta not\u00edcia emocionante.<\/p>\n

E as publica\u00e7\u00f5es cient\u00edficas continuam! A PRF financiou um estudo da Dra. Karima Djabali, juntamente com a Dra. Dayle McClintock e a Diretora M\u00e9dica da PRF, Dra. Leslie B. Gordon, que foi publicado recentemente na PNAS desta semana (Anais da Academia Nacional de Ci\u00eancias).<\/em> O estudo conclui que a prote\u00edna defeituosa produzida pelo gene Progeria (chamada progerina) se acumula nas c\u00e9lulas das paredes dos vasos das crian\u00e7as. Isso nos mostra, pela primeira vez, que h\u00e1 uma conex\u00e3o direta entre progerina e doen\u00e7a card\u00edaca.<\/p>\n

E por \u00faltimo, mas n\u00e3o menos importante, o laborat\u00f3rio do Dr. Francis Collins, que descobriu o gene da Progeria, avan\u00e7ou e produziu um camundongo Progeria que carrega um defeito gen\u00e9tico id\u00eantico ao das crian\u00e7as. Este modelo cl\u00e1ssico de camundongo Progeria mostra doen\u00e7a vascular grave e ser\u00e1 essencial para nossa compreens\u00e3o n\u00e3o apenas de como crian\u00e7as com Progeria desenvolvem doen\u00e7as card\u00edacas, mas, ainda mais importante, ser\u00e3o excelentes modelos para testar novos tratamentos, como FTI e terapias gen\u00e9ticas no tratamento e cura da Progeria. E este modelo tamb\u00e9m pode ser usado para explorar doen\u00e7as cardiovasculares em geral. Temos orgulho de dizer que nossa Diretora M\u00e9dica, Dra. Leslie B. Gordon, \u00e9 coautora. O estudo aparece na PNAS desta semana.<\/p>\n

C\u00f3pias de ambos os artigos da PNAS podem ser encontradas no site dos Anais das Academias Nacionais de Ci\u00eancias em www.pnas.org<\/a><\/p>\n

Tr\u00eas estudos em um m\u00eas \u2013 UAU! Estamos realmente cozinhando em dire\u00e7\u00e3o \u00e0 cura. Obrigado a todos os pesquisadores que est\u00e3o trabalhando duro todos os dias para ajudar crian\u00e7as com Prog\u00e9ria e os milh\u00f5es de pessoas que sofrem de doen\u00e7as card\u00edacas em todo o mundo. E obrigado \u00e0s fam\u00edlias e crian\u00e7as, e a todos os nossos doadores por tornarem tudo isso poss\u00edvel.<\/strong><\/p>\n

JUNTOS, N\u00d3S VAI<\/em> ENCONTRE A CURA!<\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"

[et_pb_section fb_built=\u201d1\u2033 _builder_version=\u201d3.22\u2033][et_pb_row _builder_version=\u201d3.25\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201drepeat\u201d][et_pb_column type=\u201d4_4\u2033 _builder_version=\u201d3.25\u2033 custom_padding=\u201d|||\u201d Pesquisadores da UCLA, financiados pela PRF, utilizaram um modelo murino de progeria para testar um poss\u00edvel tratamento medicamentoso para crian\u00e7as com a doen\u00e7a. O estudo, publicado na revista Science em 16 de fevereiro, constatou que o medicamento FTI melhora alguns sintomas da progeria. Em [\u2026]<\/p>","protected":false},"author":1,"featured_media":2043,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"

[vc_custom_heading text=\"Three studies released that bring us closer than ever to understanding Progeria and to disease treatment\" font_container=\"tag:h1|text_align:left\" use_theme_fonts=\"yes\"]PRF-funded, UCLA researchers have taken a Progeria-like mouse model and tested a potential drug treatment for children with Progeria. Their study released in Science Feb.16th has found that this FTI drug improves some signs of the disease.<\/p>

In September The Progeria Research Foundation was pleased to announce that PRF-funded researchers had published studies supporting a potential drug treatment for children with Progeria - Progeria cells became normalized (in a dish) when given this drug. The next phase of testing has been in animal models, and we are excited to report that a study released in Science Feb.16th has found that this FTI drug improves some signs of disease in a progeria-like mouse model. PRF helped fund UCLA researchers Dr. Loren Fong and Dr. Stephen Young for this latest, vital step towards clinical treatment trials with the children. Click here for more details<\/a> on this exciting news.<\/p>

And the scientific publications continue! PRF funded a study by Dr. Karima Djabali, along with Dr. Dayle McClintock and PRF Medical Director Dr. Leslie B. Gordon, which was just published in this week's PNAS (Proceeding of the National Academy of Sciences).<\/em> The study concludes that the defective protein produced by the Progeria gene (called progerin) builds up in cells of the children's vessel walls. This shows us, for the first tine, that there is a direct connection between progerin and heart disease.<\/p>

And last but certainly not least, the laboratory of Dr. Francis Collins, who discovered the gene for Progeria, has forged ahead and produced a Progeria mouse that carries a genetic defect identical to that of the children. This classic Progeria mouse model shows severe vascular disease, and will be pivotal to our understanding not only how children with Progeria develop heart disease, but even more importantly will be excellent models for testing new treatments such as FTI and genetic therapies in treating and curing Progeria, And this model can also be used to explore cardiovascular disease in general. We are proud to say that our Medical Director, Dr. Leslie B. Gordon, is a co-author. The study appears in this week's PNAS.<\/p>

Copies of both PNAS articles can be found at the website of the Proceedings of the National Academies of Science at www.pnas.org<\/a><\/p>

Three studies in one month - WOW! We are really cooking towards the cure. Thank you to all of those researchers who are working hard every day to help children with Progeria and the millions of people who suffer from heart disease throughout the world. And thanks to the families and children, and all of our donors for making this all possible.<\/strong><\/p>

TOGETHER, WE WILL<\/em> FIND THE CURE!<\/strong><\/p>","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-2113","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"yoast_head":"\nThree studies released that bring us closer than ever to understanding Progeria and to disease treatment - The Progeria Research Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.progeriaresearch.org\/pt\/2006\/02\/16\/three-studies-released-that-bring-us-closer-than-ever-to-understanding-progeria-and-to-disease-treatment\/\" \/>\n<meta property=\"og:locale\" content=\"pt_PT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Three studies released that bring us closer than ever to understanding Progeria and to disease treatment - The Progeria Research Foundation\" \/>\n<meta property=\"og:description\" content=\"[et_pb_section fb_built=”1″ _builder_version=”3.22″][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.6.5″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” hover_enabled=”0″ sticky_enabled=”0″] PRF-funded, UCLA researchers have taken a Progeria-like mouse model and tested a potential drug treatment for children with Progeria. 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Funda\u00e7\u00e3o de Pesquisa da Progeria","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.progeriaresearch.org\/pt\/2006\/02\/16\/three-studies-released-that-bring-us-closer-than-ever-to-understanding-progeria-and-to-disease-treatment\/","og_locale":"pt_PT","og_type":"article","og_title":"Three studies released that bring us closer than ever to understanding Progeria and to disease treatment - The Progeria Research Foundation","og_description":"[et_pb_section fb_built=”1″ _builder_version=”3.22″][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.6.5″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” hover_enabled=”0″ sticky_enabled=”0″] PRF-funded, UCLA researchers have taken a Progeria-like mouse model and tested a potential drug treatment for children with Progeria. 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