\u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u062a\u0642\u0631\u06cc\u0628\u0627\u064b 4 \u0645\u06cc\u06ba \u0633\u06d2 1 \u0645\u06cc\u06ba \u06c1\u0648\u062a\u0627 \u06c1\u06d2 - 8 \u0645\u0644\u06cc\u0646 \u0646\u0648\u0632\u0627\u0626\u06cc\u062f\u06c1\u060c \u062f\u0648\u0646\u0648\u06ba \u062c\u0646\u0633\u0648\u06ba \u0627\u0648\u0631 \u062a\u0645\u0627\u0645 \u0646\u0633\u0644\u0648\u06ba \u06a9\u0648 \u06cc\u06a9\u0633\u0627\u06ba \u0637\u0648\u0631 \u067e\u0631 \u0645\u062a\u0627\u062b\u0631 \u06a9\u0631\u062a\u0627 \u06c1\u06d2\u06d4 18-20 \u0645\u0644\u06cc\u0646 \u0632\u0646\u062f\u06c1 \u0627\u0641\u0631\u0627\u062f \u0645\u06cc\u06ba \u0633\u06d2 \u0627\u06cc\u06a9 \u06a9\u0648 \u06a9\u0644\u0627\u0633\u06a9 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u06c1\u06d2\u060c \u0627\u0648\u0631 \u0627\u0646\u062f\u0627\u0632\u06d2 \u06a9\u06d2 \u0645\u0637\u0627\u0628\u0642 \u062f\u0646\u06cc\u0627 \u0628\u06be\u0631 \u0645\u06cc\u06ba \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u06a9\u06d2 \u0633\u0627\u062a\u06be \u0631\u06c1\u0646\u06d2 \u0648\u0627\u0644\u06d2 400 \u0628\u0686\u06d2 \u06c1\u06cc\u06ba\u06d4 \u0686\u0648\u0646\u06a9\u06c1 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0631\u06cc\u0633\u0631\u0686 \u0641\u0627\u0624\u0646\u0688\u06cc\u0634\u0646 (PRF) 1999 \u0645\u06cc\u06ba \u0628\u0646\u0627\u0626\u06cc \u06af\u0626\u06cc \u062a\u06be\u06cc\u060c \u06c1\u0645 \u0646\u06d2 72 \u0645\u0645\u0627\u0644\u06a9 \u0627\u0648\u0631 \u062a\u0645\u0627\u0645 \u0628\u0631\u0627\u0639\u0638\u0645\u0648\u06ba \u0645\u06cc\u06ba \u0631\u06c1\u0646\u06d2 \u0648\u0627\u0644\u06d2 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u06a9\u06d2 \u0628\u0686\u0648\u06ba \u06a9\u0648 \u062a\u0644\u0627\u0634 \u06a9\u06cc\u0627 \u0627\u0648\u0631 \u0627\u0646 \u06a9\u06cc \u0645\u062f\u062f \u06a9\u06cc \u06c1\u06d2\u06d4[2]<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n [\/et_pb_toggle][et_pb_toggle title="\u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u06a9\u06cc \u062e\u0635\u0648\u0635\u06cc\u0627\u062a \u06a9\u06cc\u0627 \u06c1\u06cc\u06ba\u061f" open_toggle_background_color=\u201d#f7f7f7\u2033 close_toggle_text_color=\u201d#ffffff\u201d \u0628\u0646\u062f_toggle_background_color=\u201d#00b2e2\u2033 icon_color=\u201d#ffc15e\u201d open_icon_color=\u201dt5min=15e\u201d open_icon_color\u201dt5min=\u201d15 \u06c1\u06cc\u06ba \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u06a9\u06cc \u062e\u0635\u0648\u0635\u06cc\u0627\u062a\u061f _builder_version=\u201d4.24.3\u2033 title_text_color=\u201d#00b2e2\u2033 background_color=\u201d#ffffff\u201d custom_margin=\u201d10px||10px||true\u201d custom_padding=\u201d|50px||50px||true\u201d animation_andirect=\u201dslide=\u201dslide animation_intensity_slide=\u201d25%\u201d link_option_url_new_window=\u201don\u201d hover_enabled=\u201d0\u2033 z_index_tablet=\u201d500\u2033 border_width_all=\u201d0px\u201d global_colors_info=\u201d{}\u201d sticky_enabled=\u201d0\u2033]<\/p>\n \u0627\u06af\u0631\u0686\u06c1 \u0648\u06c1 \u0639\u0627\u0645 \u0637\u0648\u0631 \u067e\u0631 \u0635\u062d\u062a \u0645\u0646\u062f \u0646\u0638\u0631 \u0622\u062a\u06d2 \u06c1\u06cc\u06ba\u060c \u0644\u06cc\u06a9\u0646 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0648\u0627\u0644\u06d2 \u0632\u06cc\u0627\u062f\u06c1 \u062a\u0631 \u0628\u0686\u06d2 \u0632\u0646\u062f\u06af\u06cc \u06a9\u06d2 \u067e\u06c1\u0644\u06d2 \u0633\u0627\u0644 \u06a9\u06d2 \u0627\u0646\u062f\u0631 \u06c1\u06cc \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u06a9\u06cc \u062e\u0635\u0648\u0635\u06cc\u0627\u062a \u0638\u0627\u06c1\u0631 \u06a9\u0631\u0646\u0627 \u0634\u0631\u0648\u0639 \u06a9\u0631 \u062f\u06cc\u062a\u06d2 \u06c1\u06cc\u06ba\u06d4 \u0628\u0639\u0636 \u0627\u0648\u0642\u0627\u062a \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u06a9\u06cc \u0627\u0628\u062a\u062f\u0627\u0626\u06cc \u0639\u0644\u0627\u0645\u0627\u062a \u067e\u06cc\u0679 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\u06c1\u06d2\u060c \u0644\u06cc\u06a9\u0646 \u06cc\u06c1 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0648\u0627\u0644\u06d2 \u0644\u0648\u06af\u0648\u06ba \u06a9\u0648 \u0628\u06c1\u062a \u067e\u06c1\u0644\u06d2 \u0627\u0648\u0631 \u062a\u06cc\u0632 \u0631\u0641\u062a\u0627\u0631\u06cc \u0633\u06d2 \u0645\u062a\u0627\u062b\u0631 \u06a9\u0631\u062a\u0627 \u06c1\u06d2\u06d4<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n [\/et_pb_toggle][et_pb_toggle title="\u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u06a9\u06cc \u0648\u062c\u06c1 \u06a9\u06cc\u0627 \u06c1\u06d2\u061f" open_toggle_background_color=\u201d#f7f7f7\u2033 \u0628\u0646\u062f_toggle_text_color=\u201d#ffffff\u201d \u0628\u0646\u062f_toggle_background_color=\u201d#00b2e2\u2033 icon_color=\u201d#ffc15e\u201d open_icon_color=\u201dt5min=15e\u201d open_icon_color=\u201dt5min=15e\u201d _5 \u0645\u0646\u0679 \u06a9\u0627 \u0627\u0634\u062a\u06c1\u0627\u0631 \u06c1\u06d2 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u06a9\u06cc \u0648\u062c\u06c1\u061f module_id=\u201d#ftn8\u2033 _builder_version=\u201d4.24.3\u2033 title_text_color=\u201d#00b2e2\u2033 background_color=\u201d#ffffff\u201d custom_margin=\u201d10px||10px||true\u201d custom_padding=\u201d|50px||50 \u0627\u0633\u0679\u0627\u0626\u0644\u201d|50px|| animation_direction=\u201dtop\u201d animation_intensity_slide=\u201d25%\u201d link_option_url_new_window=\u201don\u201d hover_enabled=\u201d0\u2033 z_index_tablet=\u201d500\u2033 border_width_all=\u201d0px\u201d global_colors_info=\u201d{}\u201d]\u201d \u0642\u0627\u0628\u0644 \u0627\u0633\u0679\u06a9\u06cc<\/p>\n PRF \u06a9\u06d2 \u062c\u06cc\u0646\u06cc\u0679\u06a9\u0633 \u06a9\u0646\u0633\u0648\u0631\u0634\u06cc\u0645 \u06a9\u06d2 \u0633\u0631\u06a9\u0631\u062f\u06c1 \u0633\u0627\u0626\u0646\u0633\u062f\u0627\u0646\u0648\u06ba \u06a9\u06d2 \u0627\u06cc\u06a9 \u06af\u0631\u0648\u067e \u0646\u06d2 \u0628\u0634\u0645\u0648\u0644 \u0688\u0627\u06a9\u0679\u0631 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\u06a9\u0631\u0646\u0627<\/em> \u062f\u06cc<\/em> \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627<\/em> \u062c\u06cc\u0646<\/em> \u06c1\u06d2<\/em> \u0645\u06cc\u0688\u06cc\u06a9\u0644 \u0631\u06cc\u0633\u0631\u0686 \u06a9\u0645\u06cc\u0648\u0646\u0679\u06cc \u06a9\u06d2 \u0644\u06cc\u06d2 \u0627\u06cc\u06a9 \u0628\u0691\u06cc \u06a9\u0627\u0645\u06cc\u0627\u0628\u06cc" <\/em>\u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u062c\u06cc\u0646 \u0645\u06cc\u0648\u0679\u06cc\u0634\u0646 \u0631\u067e\u0648\u0631\u0679 \u06a9\u06d2 \u0633\u06cc\u0646\u0626\u0631 \u0645\u0635\u0646\u0641 \u0688\u0627\u06a9\u0679\u0631 \u0641\u0631\u0627\u0646\u0633\u0633 \u06a9\u0648\u0644\u0646\u0632 \u0646\u06d2 \u06a9\u06c1\u0627\u06d4 "\u0627\u0633 \u062f\u0631\u06cc\u0627\u0641\u062a \u0633\u06d2 \u0646\u06c1 \u0635\u0631\u0641 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u06d2 \u0645\u062a\u0627\u062b\u0631\u06c1 \u0628\u0686\u0648\u06ba \u0627\u0648\u0631 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<\/em>(\u062a\u0644\u0641\u0638 "lamin-A")\u06d4 \u062f\u06cc \u0627\u06cc\u0644 \u0627\u06cc\u0645 \u0627\u06cc\u0646 \u0627\u06d2 <\/em>\u062c\u06cc\u0646 \u0644\u0627\u0645\u06cc\u0646 \u0627\u06d2 \u067e\u0631\u0648\u0679\u06cc\u0646 \u062a\u06cc\u0627\u0631 \u06a9\u0631\u062a\u0627 \u06c1\u06d2\u060c \u062c\u0648 \u0633\u0627\u062e\u062a\u06cc \u0633\u06c1\u0627\u0631\u0648\u06ba \u06a9\u0627 \u062d\u0635\u06c1 \u06c1\u06d2 \u062c\u0648 \u0633\u06cc\u0644 \u06a9\u06d2 \u0645\u0631\u06a9\u0632\u06d2 \u06a9\u0648 \u0627\u06cc\u06a9 \u0633\u0627\u062a\u06be \u0631\u06a9\u06be\u062a\u0627 \u06c1\u06d2 \u0627\u0648\u0631 \u062e\u0644\u06cc\u0648\u06ba \u06a9\u0648 \u0635\u062d\u062a \u0645\u0646\u062f \u0631\u06a9\u06be\u0646\u06d2 \u0645\u06cc\u06ba \u0645\u062f\u062f \u06a9\u0631\u062a\u0627 \u06c1\u06d2\u06d4 \u063a\u06cc\u0631 \u0645\u0639\u0645\u0648\u0644\u06cc \u0644\u0627\u0645\u06cc\u0646 A \u067e\u0631\u0648\u0679\u06cc\u0646 \u062c\u0648 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u06a9\u0627 \u0633\u0628\u0628 \u0628\u0646\u062a\u0627 \u06c1\u06d2 \u06a9\u06c1\u0644\u0627\u062a\u0627 \u06c1\u06d2\u06d4 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0646<\/em><\/strong>. \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0646 \u062e\u0644\u06cc\u0627\u062a \u06a9\u0648 \u063a\u06cc\u0631 \u0645\u0633\u062a\u062d\u06a9\u0645 \u0628\u0646\u0627\u062a\u0627 \u06c1\u06d2\u060c \u062c\u0648 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0645\u06cc\u06ba \u0642\u0628\u0644 \u0627\u0632 \u0648\u0642\u062a \u0628\u0691\u06be\u0627\u067e\u06d2 \u0627\u0648\u0631 \u0628\u06cc\u0645\u0627\u0631\u06cc \u06a9\u0627 \u0628\u0627\u0639\u062b \u0628\u0646\u062a\u0627 \u06c1\u06d2\u06d4<\/p>\n [\/et_pb_toggle][et_pb_toggle title=\u201d\u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u06a9\u0627 \u0639\u0645\u0631 \u0628\u0691\u06be\u0646\u06d2 \u0633\u06d2 \u06a9\u06cc\u0627 \u062a\u0639\u0644\u0642 \u06c1\u06d2\u061f open_toggle_background_color=\u201d#f7f7f7\u2033 close_toggle_text_color=\u201d#ffffff\u201d \u0628\u0646\u062f_toggle_background_color=\u201d#00b2e2\u2033 icon_color=\u201d#ffc15e\u201d open_icon_color=\u201dt5mind=15e\u201d _5_5 \u0645\u0646\u0679 \u06a9\u0627 \u0627\u0634\u062a\u06c1\u0627\u0631=15_5 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u06a9\u0627 \u0639\u0645\u0631 \u0628\u0691\u06be\u0646\u06d2 \u0633\u06d2 \u06a9\u06cc\u0627 \u062a\u0639\u0644\u0642 \u06c1\u06d2\u061f module_id=\u201d#ftn8\u2033 _builder_version=\u201d4.24.3\u2033 title_text_color=\u201d#00b2e2\u2033 background_color=\u201d#ffffff\u201d custom_margin=\u201d10px||10px||true\u201d custom_padding=\u201d|50px||50 \u0627\u0633\u0679\u0627\u0626\u0644\u201d|50px|| animation_direction=\u201dtop\u201d animation_intensity_slide=\u201d25%\u201d link_option_url_new_window=\u201don\u201d hover_enabled=\u201d0\u2033 z_index_tablet=\u201d500\u2033 border_width_all=\u201d0px\u201d global_colors_info=\u201d{}\u201d]\u201d \u0642\u0627\u0628\u0644 \u0627\u0633\u0679\u06a9\u06cc<\/p>\n \u0639\u0645\u0631 \u0628\u0691\u06be\u0646\u06d2 \u06a9\u06d2 \u0639\u0645\u0644 \u0645\u06cc\u06ba \u0634\u0627\u06cc\u062f \u0633\u0628 \u0633\u06d2 \u062f\u0644\u0686\u0633\u067e \u0627\u0634\u0627\u0631\u06c1 \u06cc\u06c1 \u062f\u0631\u06cc\u0627\u0641\u062a \u06c1\u06d2 \u06a9\u06c1 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0646 \u067e\u0631\u0648\u0679\u06cc\u0646 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0627\u0648\u0631 \u0639\u0627\u0645 \u062e\u0644\u06cc\u0648\u06ba \u062f\u0648\u0646\u0648\u06ba \u0645\u06cc\u06ba \u0628\u0691\u06be\u062a\u06cc \u06c1\u0648\u0626\u06cc \u062a\u0639\u062f\u0627\u062f \u0645\u06cc\u06ba \u0645\u0648\u062c\u0648\u062f \u06c1\u06d2 \u062c\u06cc\u0633\u0627 \u06a9\u06c1 \u06c1\u0645\u0627\u0631\u06cc \u0639\u0645\u0631 \u0628\u0691\u06be\u062a\u06cc \u06c1\u06d2\u06d4 \u06c1\u0645\u0627\u0631\u06d2 \u062c\u0633\u0645 \u06c1\u0631 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\u0627\u0634\u0627\u0631\u06d2 \u0641\u0631\u0627\u06c1\u0645 \u06a9\u0631 \u0633\u06a9\u062a\u06d2 \u06c1\u06cc\u06ba\u06d4 <\/strong>\u0642\u062f\u0631\u062a\u06cc \u0639\u0645\u0631 \u0628\u0691\u06be\u0646\u06d2 \u06a9\u06d2 \u0639\u0645\u0644 \u0633\u06d2 \u0648\u0627\u0628\u0633\u062a\u06c1 \u06c1\u06d2\u06d4.<\/strong><\/p>\n<\/div>\n [\/et_pb_toggle][et_pb_toggle title="\u06a9\u06cc\u0627 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0648\u0627\u0644\u062f\u06cc\u0646 \u0633\u06d2 \u0628\u0686\u06d2 \u0645\u06cc\u06ba \u0645\u0646\u062a\u0642\u0644 \u06c1\u0648\u062a\u0627 \u06c1\u06d2\u061f open_toggle_background_color=\u201d#f7f7f7\u2033 close_toggle_text_color=\u201d#ffffff\u201d \u0628\u0646\u062f_toggle_background_color=\u201d#00b2e2\u2033 icon_color=\u201d#ffc15e\u201d open_icon_color\u201dTffc15e\u201d open_icon_color\u201dT5min\u201d_5min= \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0648\u0627\u0644\u062f\u06cc\u0646 \u0633\u06d2 \u0628\u0686\u06d2 \u0645\u06cc\u06ba \u0645\u0646\u062a\u0642\u0644 \u06c1\u0648\u0627\u061f _builder_version=\u201d4.24.3\u2033 title_text_color=\u201d#00b2e2\u2033 background_color=\u201d#ffffff\u201d custom_margin=\u201d10px||10px||true\u201d custom_padding=\u201d|50px||50px||true\u201d animation_andirect=\u201dslide=\u201dslide animation_intensity_slide=\u201d25%\u201d link_option_url_new_window=\u201don\u201d hover_enabled=\u201d0\u2033 z_index_tablet=\u201d500\u2033 border_width_all=\u201d0px\u201d global_colors_info=\u201d{}\u201d sticky_enabled=\u201d0\u2033]<\/p>\n HGPS \u0639\u0627\u0645 \u0637\u0648\u0631 \u067e\u0631 \u062e\u0627\u0646\u062f\u0627\u0646\u0648\u06ba \u0645\u06cc\u06ba \u0645\u0646\u062a\u0642\u0644 \u0646\u06c1\u06cc\u06ba \u06c1\u0648\u062a\u0627 \u06c1\u06d2\u06d4 \u062c\u06cc\u0646 \u06a9\u06cc \u062a\u0628\u062f\u06cc\u0644\u06cc \u062a\u0642\u0631\u06cc\u0628\u0627\u064b \u06c1\u0645\u06cc\u0634\u06c1 \u0627\u06cc\u06a9 \u0627\u06cc\u0633\u0627 \u0645\u0648\u0642\u0639 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_builder_version=\u201d4.24.3\u2033 title_text_color=\u201d#00b2e2\u2033 background_color=\u201d#ffffff\u201d custom_margin=\u201d10px||10px||true\u201d custom_padding=\u201d|50px||50px||true\u201d animation_andirect=\u201dslide=\u201dslide animation_intensity_slide=\u201d25%\u201d link_option_url_new_window=\u201don\u201d hover_enabled=\u201d0\u2033 z_index_tablet=\u201d500\u2033 border_width_all=\u201d0px\u201d global_colors_info=\u201d{}\u201d sticky_enabled=\u201d0\u2033]<\/p>\n \u062a\u0627\u0631\u06cc\u062e\u06cc \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u062c\u06cc\u0646 \u06a9\u06cc \u062f\u0631\u06cc\u0627\u0641\u062a \u06a9\u06cc \u0648\u062c\u06c1 \u0633\u06d2\u060c \u06c1\u0645\u0627\u0631\u06d2 \u067e\u0627\u0633 \u06c1\u06d2\u06d4 \u0628\u0686\u0648\u06ba \u06a9\u06cc \u062a\u0634\u062e\u06cc\u0635 \u06a9\u0627 \u0627\u06cc\u06a9 \u06cc\u0642\u06cc\u0646\u06cc\u060c \u0633\u0627\u0626\u0646\u0633\u06cc \u0637\u0631\u06cc\u0642\u06c1. <\/em><\/strong>\u0627\u0633 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title_text_color=\u201d#00b2e2\u2033 background_color=\u201d#ffffff\u201d custom_margin=\u201d10px||10px||true\u201d custom_padding=\u201d|50px||50 \u0627\u0633\u0679\u0627\u0626\u0644\u201d|50px|| animation_direction=\u201dtop\u201d animation_intensity_slide=\u201d25%\u201d link_option_url_new_window=\u201don\u201d hover_enabled=\u201d0\u2033 z_index_tablet=\u201d500\u2033 border_width_all=\u201d0px\u201d global_colors_info=\u201d{}\u201d]\u201d \u0642\u0627\u0628\u0644 \u0627\u0633\u0679\u06a9\u06cc<\/p>\n \u062c\u06cc \u06c1\u0627\u06ba<\/em>! \u0645\u06cc\u06ba \u062a\u0627\u0631\u06cc\u062e \u0628\u0646\u0627\u0626\u06cc \u06af\u0626\u06cc\u06d4 \u0633\u062a\u0645\u0628\u0631 2012<\/strong>\u060c \u062c\u0628 \u067e\u06c1\u0644\u06cc \u0628\u0627\u0631 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u06a9\u06d2 \u06a9\u0644\u06cc\u0646\u06cc\u06a9\u0644 \u0688\u0631\u06af \u0679\u0631\u0627\u0626\u0644 \u06a9\u06d2 \u0646\u062a\u0627\u0626\u062c \u0646\u06d2 \u06cc\u06c1 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\u06a9\u0648 \u0628\u0691\u06be\u0627\u0646\u06d2 \u0645\u06cc\u06ba \u0645\u062f\u062f \u06a9\u06cc\u06d4<\/p>\n \u062f\u06cc 2012<\/strong> \u0627\u0648\u0631 2018<\/strong> \u0645\u0637\u0627\u0644\u0639\u06c1 \u063a\u06cc\u0631 \u0645\u0639\u0645\u0648\u0644\u06cc \u06a9\u06cc \u0642\u06cc\u0627\u062f\u062a \u06a9\u06cc 2020<\/strong> \u06cc\u0648 \u0627\u06cc\u0633 \u0641\u0648\u0688 \u0627\u06cc\u0646\u0688 \u0688\u0631\u06af \u0627\u06cc\u0688\u0645\u0646\u0633\u0679\u0631\u06cc\u0634\u0646 (\u0627\u06cc\u0641 \u0688\u06cc \u0627\u06d2) \u0646\u06d2 \u0644\u0648\u0646\u0627\u0641\u0627\u0631\u0646\u06cc\u0628 \u06a9\u06cc \u0645\u0646\u0638\u0648\u0631\u06cc\u060c \u062c\u0633\u06d2 \u0627\u0628 '\u0632\u0648\u06a9\u0646\u0648\u06cc' \u06a9\u06c1\u0627 \u062c\u0627\u062a\u0627 \u06c1\u06d2\u060c \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u06a9\u06d2 \u067e\u06c1\u0644\u06d2 \u0639\u0644\u0627\u062c \u06a9\u06d2 \u0637\u0648\u0631 \u067e\u0631\u06d4 PRF \u06a9\u06d2 \u0645\u0634\u0646 \u0645\u06cc\u06ba \u0627\u06cc\u06a9 \u0627\u06c1\u0645 \u0633\u0646\u06af \u0645\u06cc\u0644\u060c \u06cc\u06c1 \u0645\u0646\u0638\u0648\u0631\u06cc 13 \u0633\u0627\u0644 \u06a9\u06cc \u06a9\u0644\u06cc\u0646\u06cc\u06a9\u0644 \u062a\u062d\u0642\u06cc\u0642 \u06a9\u0627 \u0627\u062e\u062a\u062a\u0627\u0645 \u062a\u06be\u0627 \u062c\u0633 \u0645\u06cc\u06ba \u0686\u0627\u0631 \u06a9\u0644\u06cc\u0646\u06cc\u06a9\u0644 \u0679\u0631\u0627\u0626\u0644\u0632 \u0634\u0627\u0645\u0644 \u062a\u06be\u06d2\u060c \u062c\u0633 \u0633\u06d2 37 \u0645\u0645\u0627\u0644\u06a9 \u06a9\u06d2 96 \u0628\u0686\u0648\u06ba \u06a9\u0648 \u0639\u0644\u0627\u062c \u06a9\u06d2 \u0644\u06cc\u06d2 \u0628\u0648\u0633\u0679\u0646 \u0644\u0627\u06cc\u0627 \u06af\u06cc\u0627\u06d4<\/p>\n \u0627\u0633 \u0633\u0646\u06af \u0645\u06cc\u0644 \u06a9\u06d2 \u0633\u0627\u062a\u06be\u060c \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0627\u06cc\u0641 \u0688\u06cc \u0627\u06d2 \u0633\u06d2 \u0645\u0646\u0638\u0648\u0631 \u0634\u062f\u06c1 \u0639\u0644\u0627\u062c \u06a9\u06d2 \u0633\u0627\u062a\u06be \u0646\u0627\u06cc\u0627\u0628 \u0628\u06cc\u0645\u0627\u0631\u06cc\u0648\u06ba \u06a9\u06d2 5% \u0633\u06d2 \u06a9\u0645 \u06a9\u06cc \u0635\u0641 \u0645\u06cc\u06ba \u0634\u0627\u0645\u0644 \u06c1\u0648 \u06af\u06cc\u0627\u06d4<\/p>\n \u0644\u0648\u0646\u0627\u0641\u0627\u0631\u0646\u06cc\u0628 \u06a9\u06cc \u0627\u06cc\u0641 \u0688\u06cc \u0627\u06d2 \u06a9\u06cc \u0645\u0646\u0638\u0648\u0631\u06cc \u06a9\u06d2 \u0641\u0648\u0631\u0627\u064b \u0628\u0639\u062f\u060c \u06cc\u0648\u0631\u067e\u06cc \u0645\u06cc\u0688\u06cc\u0633\u0646 \u0627\u06cc\u062c\u0646\u0633\u06cc (EMA) \u0646\u06d2 \u062c\u0648\u0644\u0627\u0626\u06cc 2022 \u0645\u06cc\u06ba \u0644\u0648\u0646\u0627\u0641\u0627\u0631\u0646\u06cc\u0628 \u06a9\u0648 \u06cc\u0648\u0631\u067e \u0645\u06cc\u06ba \u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u06a9\u06d2 \u0644\u06cc\u06d2 \u0645\u0646\u0638\u0648\u0631 \u06a9\u06cc\u0627\u060c \u0627\u0633 \u06a9\u06d2 \u0628\u0639\u062f \u062c\u0646\u0648\u0631\u06cc 2024 \u0645\u06cc\u06ba \u062c\u0627\u067e\u0627\u0646 \u06a9\u06cc \u0648\u0632\u0627\u0631\u062a \u0635\u062d\u062a\u060c \u0645\u062d\u0646\u062a \u0627\u0648\u0631 \u0628\u06c1\u0628\u0648\u062f (MHLW) \u0646\u06d2 \u0645\u0646\u0638\u0648\u0631\u06cc \u062f\u06cc\u06d4<\/p>\n \u0644\u0648\u0646\u0627\u0641\u0627\u0631\u0646\u06cc\u0628 \u06a9\u06d2 \u0628\u063a\u06cc\u0631\u060c \u0628\u0686\u06d2 14.5 \u0633\u0627\u0644 \u06a9\u06cc \u0627\u0648\u0633\u0637 \u0639\u0645\u0631 \u0645\u06cc\u06ba \u0627\u06cc\u062a\u06be\u0631\u0648\u0633\u06a9\u0644\u0631\u0648\u0633\u06cc\u0633 (\u062f\u0644 \u06a9\u06cc \u0646\u0627\u06a9\u0627\u0645\u06cc \u06cc\u0627 \u0641\u0627\u0644\u062c) \u0633\u06d2 \u0645\u0631 \u062c\u0627\u062a\u06d2 \u06c1\u06cc\u06ba\u06d4 [6]<\/a><\/em>\u00a0. \u0637\u0648\u06cc\u0644 \u0645\u062f\u062a\u06cc \u0644\u0648\u0646\u0627\u0641\u0627\u0631\u0646\u06cc\u0628 \u06a9\u06d2 \u0639\u0644\u0627\u062c \u06a9\u06d2 \u0633\u0627\u062a\u06be\u060c \u0642\u0644\u0628\u06cc \u0635\u062d\u062a \u0646\u0645\u0627\u06cc\u0627\u06ba \u0637\u0648\u0631 \u067e\u0631 \u0628\u06c1\u062a\u0631 \u06c1\u0648\u062a\u06cc \u06c1\u06d2\u060c \u0627\u0648\u0631 \u0645\u062a\u0648\u0642\u0639 \u0639\u0645\u0631 \u0645\u06cc\u06ba \u0627\u0648\u0633\u0637\u0627\u064b 4.5 \u0633\u0627\u0644 \u06a9\u0627 \u0627\u0636\u0627\u0641\u06c1 \u06c1\u0648\u0627 \u06c1\u06d2\u06d47<\/span>. \u00a0<\/strong>\u06cc\u06c1 \u0627\u0648\u0633\u0637 \u0639\u0645\u0631 \u0645\u06cc\u06ba 30% \u0627\u0636\u0627\u0641\u06d2 \u0633\u06d2 \u0632\u06cc\u0627\u062f\u06c1 \u06c1\u06d2\u060c 14.5 \u0633\u0627\u0644 \u0633\u06d2 \u062a\u0642\u0631\u06cc\u0628\u0627\u064b 20 \u0633\u0627\u0644 \u06a9\u06cc \u0639\u0645\u0631 \u062a\u06a9!<\/p>\n \u0644\u0648\u0646\u0627\u0641\u0627\u0631\u0646\u06cc\u0628 \u062a\u06be\u0631\u0627\u067e\u06cc \u06a9\u06cc \u0648\u062c\u06c1 \u0633\u06d2 \u0628\u0686\u0648\u06ba \u06a9\u06d2 \u0637\u0648\u06cc\u0644 \u0639\u0631\u0635\u06d2 \u062a\u06a9 \u0632\u0646\u062f\u06c1 \u0631\u06c1\u0646\u06d2 \u06a9\u06d2 \u0633\u0627\u062a\u06be\u060c \u0645\u0639\u0627\u0644\u062c\u06cc\u0646 \u0628\u0691\u06cc \u0639\u0645\u0631 \u06a9\u06d2 \u0628\u0686\u0648\u06ba \u0627\u0648\u0631 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0645\u06cc\u06ba \u0645\u0628\u062a\u0644\u0627 \u0646\u0648\u062c\u0648\u0627\u0646 \u0628\u0627\u0644\u063a\u0648\u06ba \u0645\u06cc\u06ba aortic stenosis (\u0627\u06cc\u06a9 \u0627\u06c1\u0645 \u062f\u0644 \u06a9\u06d2 \u0648\u0627\u0644\u0648 \u06a9\u06cc \u062a\u0646\u06af\u06cc) \u06a9\u0648 \u0627\u06cc\u06a9 \u0645\u0633\u0626\u0644\u06c1 \u06a9\u06d2 \u0637\u0648\u0631 \u067e\u0631 \u062f\u06cc\u06a9\u06be \u0631\u06c1\u06d2 \u06c1\u06cc\u06ba \u062c\u0648 \u0632\u0646\u062f\u06af\u06cc \u0628\u0686\u0627\u0646\u06d2 \u0648\u0627\u0644\u06cc \u0633\u0631\u062c\u0631\u06cc \u06a9\u06d2 \u0644\u06cc\u06d2 \u0645\u0648\u0632\u0648\u06ba \u06c1\u0648 \u0633\u06a9\u062a\u0627 \u06c1\u06d2\u06d4 \u0628\u0639\u0636 \u0635\u0648\u0631\u062a\u0648\u06ba \u0645\u06cc\u06ba\u060c \u062f\u0644 \u06a9\u06d2 \u0646\u0626\u06d2 \u0648\u0627\u0644\u0648\u0632 \u062f\u0627\u062e\u0644 \u06a9\u0631\u0646\u06d2 \u06cc\u0627 \u062f\u0644 \u06a9\u0648 \u0633\u067e\u0644\u0627\u0626\u06cc \u06a9\u0631\u0646\u06d2 \u0648\u0627\u0644\u06cc \u062e\u0648\u0646 \u06a9\u06cc \u0646\u0627\u0644\u06cc\u0648\u06ba \u06a9\u0648 \u06a9\u06be\u0648\u0644\u0646\u06d2 \u06a9\u06cc \u0633\u0631\u062c\u0631\u06cc \u0646\u06d2 \u0628\u06cc\u0645\u0627\u0631\u06cc \u06a9\u06d2 \u0628\u0639\u062f \u06a9\u06d2 \u0645\u0631\u0627\u062d\u0644 \u0645\u06cc\u06ba \u0645\u0631\u06cc\u0636\u0648\u06ba \u06a9\u06cc \u0635\u062d\u062a \u06a9\u0648 \u0628\u06c1\u062a\u0631 \u0628\u0646\u0627\u0646\u06d2 \u0645\u06cc\u06ba \u0645\u062f\u062f \u06a9\u06cc \u06c1\u06d2\u06d4[8]<\/span><\/a>.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n [\/et_pb_toggle][et_pb_toggle title="\u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u06a9\u06cc \u062a\u062d\u0642\u06cc\u0642 \u0645\u06cc\u06ba \u062d\u0627\u0644\u06cc\u06c1 \u067e\u06cc\u0634 \u0631\u0641\u062a \u06a9\u06cc\u0627 \u06c1\u06cc\u06ba\u061f open_toggle_background_color=\u201d#f7f7f7\u2033 close_toggle_text_color=\u201d#ffffff\u201d \u0628\u0646\u062f_toggle_background_color=\u201d#00b2e2\u2033 icon_color=\u201d#ffc15e\u201d open_icon_color=\u201dt5min=15e\u201d open_icon_color\u201dt5min=\u201d15 \u06c1\u06cc\u06ba \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u062a\u062d\u0642\u06cc\u0642 \u0645\u06cc\u06ba \u062d\u0627\u0644\u06cc\u06c1 \u067e\u06cc\u0634 \u0631\u0641\u062a\u061f module_id=\u201d#ftn8\u2033 _builder_version=\u201d4.24.3\u2033 title_text_color=\u201d#00b2e2\u2033 background_color=\u201d#ffffff\u201d custom_margin=\u201d10px||10px||true\u201d custom_padding=\u201d|50px||50 \u0627\u0633\u0679\u0627\u0626\u0644\u201d|50px|| animation_direction=\u201dtop\u201d animation_intensity_slide=\u201d25%\u201d link_option_url_new_window=\u201don\u201d hover_enabled=\u201d0\u2033 z_index_tablet=\u201d500\u2033 border_width_all=\u201d0px\u201d global_colors_info=\u201d{}\u201d]\u201d \u0642\u0627\u0628\u0644 \u0627\u0633\u0679\u06a9\u06cc<\/p>\n PRF \u06a9\u06cc \u062a\u0631\u0642\u06cc \u0645\u06cc\u06ba \u0628\u06c1\u062a \u0632\u06cc\u0627\u062f\u06c1 \u0645\u0644\u0648\u062b \u06c1\u06d2\u06d4 \u062a\u06cc\u0646 \u062f\u06cc\u06af\u0631 \u0639\u0644\u0627\u062c \u06a9\u06d2 \u0631\u0627\u0633\u062a\u06d2<\/strong>\u060c \u062c\u0646 \u0645\u06cc\u06ba \u0633\u06d2 \u06c1\u0631 \u0627\u06cc\u06a9 \u0646\u06d2 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0645\u0627\u0624\u0633 \u0645\u0627\u0688\u0644\u0632 \u0645\u06cc\u06ba \u0645\u0637\u0627\u0644\u0639\u06c1 \u06a9\u0631\u0646\u06d2 \u067e\u0631 \u0639\u0645\u0631 \u06a9\u06cc \u0645\u062e\u062a\u0644\u0641 \u0633\u0637\u062d\u0648\u06ba \u06a9\u0648 \u062f\u06a9\u06be\u0627\u06cc\u0627 \u06c1\u06d2 \u2013 50% \u0633\u06d2 \u0644\u06d2 \u06a9\u0631 \u062d\u06cc\u0631\u0627\u0646 \u06a9\u0646 140% \u062a\u06a9! \u06c1\u0645\u0627\u0631\u06d2 \u0627\u06c1\u062f\u0627\u0641 \u0627\u06cc\u0633\u06d2 \u0646\u0626\u06d2 \u0639\u0644\u0627\u062c \u062f\u0631\u06cc\u0627\u0641\u062a \u06a9\u0631\u0646\u0627 \u06c1\u06cc\u06ba \u062c\u0648 \u0627\u06a9\u06cc\u0644\u06d2 \u0644\u0648\u0646\u0627\u0641\u0627\u0631\u0646\u06cc\u0628 \u0633\u06d2 \u0628\u06be\u06cc \u0628\u06c1\u062a\u0631 \u06a9\u0627\u0645 \u06a9\u0631\u06cc\u06ba \u06af\u06d2\u060c \u0627\u0648\u0631 \u0628\u0627\u0644\u0622\u062e\u0631 \u062c\u06cc\u0646\u06cc\u0627\u062a\u06cc \u062a\u063a\u06cc\u0631 \u06a9\u0648 \u062f\u0631\u0633\u062a \u06a9\u0631\u06a9\u06d2 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u06a9\u0627 \u0639\u0644\u0627\u062c \u06a9\u0631\u06cc\u06ba\u06d4 \u06c1\u0645 \u0628\u06cc\u0645\u0627\u0631\u06cc \u06a9\u0648 \u067e\u0631\u0648\u0679\u06cc\u0646\u060c \u0622\u0631 \u0627\u06cc\u0646 \u0627\u06d2 \u0627\u0648\u0631 \u0688\u06cc \u0627\u06cc\u0646 \u0627\u06d2 \u06a9\u06cc \u0633\u0637\u062d \u067e\u0631 \u0646\u0634\u0627\u0646\u06c1 \u0628\u0646\u0627 \u0631\u06c1\u06d2 \u06c1\u06cc\u06ba\u06d4<\/em><\/strong><\/p>\n "\u06c1\u0645\u0627\u0631\u06d2 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0645\u0627\u0624\u0633 \u0645\u0627\u0688\u0644 \u0645\u06cc\u06ba \u0627\u0633 \u0688\u0631\u0627\u0645\u0627\u0626\u06cc \u0631\u062f\u0639\u0645\u0644 \u06a9\u0648 \u062f\u06cc\u06a9\u06be\u0646\u0627 \u0627\u06cc\u06a9 \u0633\u0628 \u0633\u06d2 \u062f\u0644\u0686\u0633\u067e \u0639\u0644\u0627\u062c \u06a9\u06cc \u067e\u06cc\u0634\u0631\u0641\u062a \u06c1\u06d2 \u062c\u0633 \u06a9\u0627 \u0645\u06cc\u06ba 40 \u0633\u0627\u0644\u0648\u06ba \u0645\u06cc\u06ba \u0628\u0637\u0648\u0631 \u0645\u0639\u0627\u0644\u062c-\u0633\u0627\u0626\u0646\u0633 \u062f\u0627\u0646 \u0631\u06c1\u0627 \u06c1\u0648\u06ba\u060c" \u0641\u0631\u0627\u0646\u0633\u0633 \u06a9\u0648\u0644\u0646\u0632\u060c \u0627\u06cc\u0645 \u0688\u06cc\u060c \u067e\u06cc \u0627\u06cc\u0686 \u0688\u06cc \u0646\u06d2 \u06a9\u06c1\u0627\u06d4<\/em><\/p>\n [\/et_pb_toggle][et_pb_toggle title="PRF \u0645\u0633\u062a\u0642\u0628\u0644 \u06a9\u06d2 \u0639\u0644\u0627\u062c \u06a9\u06cc \u0637\u0631\u0641 \u062a\u062d\u0642\u06cc\u0642 \u06a9\u0648 \u06a9\u06cc\u0633\u06d2 \u0622\u06af\u06d2 \u0628\u0691\u06be\u0627 \u0631\u06c1\u0627 \u06c1\u06d2\u060c \u0627\u0648\u0631 \u0622\u062c \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0645\u06cc\u06ba \u0645\u0628\u062a\u0644\u0627 \u0628\u0686\u0648\u06ba \u06a9\u06cc \u0645\u062f\u062f \u06a9\u0631 \u0631\u06c1\u0627 \u06c1\u06d2\u061f" open_toggle_background_color=\u201d#f7f7f7\u2033 close_toggle_text_color=\u201d#ffffff\u201d \u0628\u0646\u062f_toggle_background_color=\u201d#00b2e2\u2033 icon_color=\u201d#ffc15e\u201d open_icon_color=\u201dTffc15e\u201d open_icon_color\u201dHow=15min\u201d PRF \u0645\u0633\u062a\u0642\u0628\u0644 \u06a9\u06d2 \u0639\u0644\u0627\u062c \u06a9\u06cc \u0637\u0631\u0641 \u062a\u062d\u0642\u06cc\u0642 \u06a9\u0648 \u0622\u06af\u06d2 \u0628\u0691\u06be\u0627 \u0631\u06c1\u0627 \u06c1\u06d2\u060c \u0627\u0648\u0631 \u0622\u062c \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0645\u06cc\u06ba \u0645\u0628\u062a\u0644\u0627 \u0628\u0686\u0648\u06ba \u06a9\u06cc \u0645\u062f\u062f \u06a9\u0631 \u0631\u06c1\u0627 \u06c1\u06d2\u061f _builder_version=\u201d4.24.3\u2033 title_text_color=\u201d#00b2e2\u2033 background_color=\u201d#ffffff\u201d custom_margin=\u201d10px||10px||true\u201d custom_padding=\u201d|50px||50px||true\u201d animation_andirect=\u201dslide=\u201dslide animation_intensity_slide=\u201d25%\u201d link_option_url_new_window=\u201don\u201d hover_enabled=\u201d0\u2033 z_index_tablet=\u201d500\u2033 border_width_all=\u201d0px\u201d global_colors_info=\u201d{}\u201d sticky_enabled=\u201d0\u2033]<\/p>\n \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0645\u06cc\u06ba \u0645\u0628\u062a\u0644\u0627 \u06a9\u0633\u06cc \u06a9\u06cc \u062f\u06cc\u06a9\u06be \u0628\u06be\u0627\u0644 \u06a9\u0631\u0646\u06d2 \u06a9\u06d2 \u0628\u0627\u0631\u06d2 \u0645\u06cc\u06ba \u0628\u06c1\u062a \u0633\u06d2 \u0633\u0648\u0627\u0644\u0627\u062a \u06a9\u06d2 \u062c\u0648\u0627\u0628\u0627\u062a \u062f\u06cc\u0646\u06d2 \u06a9\u06d2 \u0644\u06cc\u06d2\u060c PRF \u0634\u0627\u0626\u0639 \u06c1\u0648\u0627\u06d4 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u06c1\u06cc\u0646\u0688 \u0628\u06a9<\/strong><\/a>\u00a0<\/strong>\u062e\u0627\u0646\u062f\u0627\u0646\u0648\u06ba \u0627\u0648\u0631 \u0688\u0627\u06a9\u0679\u0631\u0648\u06ba \u06a9\u06d2 \u0644\u06cc\u06d2\u06d4 \u0635\u062d\u062a \u06a9\u06d2 \u0628\u0646\u06cc\u0627\u062f\u06cc \u062d\u0642\u0627\u0626\u0642 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<\/strong><\/a>\u062c\u0648 \u0645\u0645\u06a9\u0646\u06c1 \u0639\u0644\u0627\u062c \u06a9\u06cc \u062c\u0627\u0646\u0686 \u06a9\u0631 \u0631\u06c1\u06d2 \u06c1\u06cc\u06ba\u060c \u0627\u0648\u0631 \u0622\u062c \u062a\u06a9\u060c \u0686\u0627\u0631 \u06a9\u0644\u06cc\u0646\u06a9\u0644 \u0679\u0631\u0627\u0626\u0644\u0632 \u06a9\u0648 \u0641\u0646\u0688 \u0627\u0648\u0631 \u062a\u0639\u0627\u0648\u0646 \u0641\u0631\u0627\u06c1\u0645 \u06a9\u0631 \u0686\u06a9\u06d2 \u06c1\u06cc\u06ba\u06d4 PRF \u0627\u0645\u06cc\u062f \u0627\u0641\u0632\u0627 \u062f\u0648\u0627\u0626\u06cc\u0648\u06ba \u06a9\u06cc \u06c1\u0645\u0627\u0631\u06cc \u062a\u0644\u0627\u0634 \u0645\u06cc\u06ba \u06a9\u0648\u0626\u06cc \u06a9\u0633\u0631 \u0646\u06c1\u06cc\u06ba \u0686\u06be\u0648\u0691 \u0631\u06c1\u0627 \u06c1\u06d2 \u062c\u0648 \u06c1\u0645\u06cc\u06ba \u0639\u0644\u0627\u062c \u06a9\u06d2 \u0642\u0631\u06cc\u0628 \u0644\u0627\u0626\u06d2 \u06af\u06cc\u06d4<\/em><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n [\/et_pb_toggle][et_pb_toggle title="\u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0645\u06cc\u06ba \u0645\u0628\u062a\u0644\u0627 \u0628\u0686\u0648\u06ba \u06a9\u06cc \u0645\u062f\u062f \u06a9\u06d2 \u0644\u06cc\u06d2 \u0622\u067e \u06a9\u06cc\u0627 \u06a9\u0631 \u0633\u06a9\u062a\u06d2 \u06c1\u06cc\u06ba\u061f" open_toggle_background_color=\u201d#f7f7f7\u2033 \u0628\u0646\u062f_toggle_text_color=\u201d#ffffff\u201d \u0628\u0646\u062f_toggle_background_color=\u201d#00b2e2\u2033 icon_color=\u201d#ffc15e\u201d open_icon_color=\u201dt5min_5min\u201d_5_5 \u0645\u0646\u0679 \u06a9\u0627 \u0627\u0634\u062a\u06c1\u0627\u0631=150 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0645\u06cc\u06ba \u0645\u0628\u062a\u0644\u0627 \u0628\u0686\u0648\u06ba \u06a9\u06cc \u0645\u062f\u062f \u06a9\u0631\u0646\u0627\u061f _builder_version=\u201d4.24.3\u2033 title_text_color=\u201d#00b2e2\u2033 background_color=\u201d#ffffff\u201d custom_margin=\u201d10px||10px||true\u201d custom_padding=\u201d|50px||50px||true\u201d animation_andirect=\u201dslide=\u201dslide animation_intensity_slide=\u201d25%\u201d link_option_url_new_window=\u201don\u201d hover_enabled=\u201d0\u2033 z_index_tablet=\u201d500\u2033 border_width_all=\u201d0px\u201d global_colors_info=\u201d{}\u201d sticky_enabled=\u201d0\u2033]<\/p>\n \u06c1\u0645 \u0622\u067e \u06a9\u06d2 \u0633\u0627\u062a\u06be \u062c\u0691\u0646\u06d2 \u06a9\u06d2 \u0645\u0646\u062a\u0638\u0631 \u06c1\u06cc\u06ba!<\/strong><\/li>\n<\/ul>\n <\/p>\n [\/et_pb_toggle]<\/p>\n \u062d\u0648\u0627\u0644\u06c1 \u062c\u0627\u062a<\/strong><\/span><\/a><\/p>\n [1] \u062f\u06cc\u06af\u0631 \u067e\u0631\u0648\u062c\u06cc\u0631\u0627\u0626\u0688 \u0633\u0646\u0688\u0631\u0648\u0645 \u0645\u06cc\u06ba \u0648\u0631\u0646\u0631 \u0633\u0646\u0688\u0631\u0648\u0645 \u0634\u0627\u0645\u0644 \u06c1\u06d2\u060c \u062c\u0633\u06d2 "\u0627\u06cc\u0688\u0644\u0679 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627" \u0628\u06be\u06cc \u06a9\u06c1\u0627 \u062c\u0627\u062a\u0627 \u06c1\u06d2 \u062c\u0648 \u0646\u0648\u0639\u0645\u0631\u06cc \u06a9\u06d2 \u0622\u062e\u0631 \u062a\u06a9 \u0634\u0631\u0648\u0639 \u0646\u06c1\u06cc\u06ba \u06c1\u0648\u062a\u0627\u060c \u062c\u0633 \u06a9\u06cc \u0639\u0645\u0631 40 \u0627\u0648\u0631 50 \u06a9\u06cc \u062f\u06c1\u0627\u0626\u06cc \u0645\u06cc\u06ba \u06c1\u0648\u062a\u06cc \u06c1\u06d2\u06d4<\/p>\n [2]<\/a> \u0632\u0646\u062f\u06c1 \u0628\u0686\u06d2 \u06a9\u06c1\u0627\u06ba \u0631\u06c1\u062a\u06d2 \u06c1\u06cc\u06ba \u0627\u0633 \u06a9\u06d2 \u0646\u0642\u0634\u06d2 \u06a9\u06d2 \u0644\u06cc\u06d2\u060c \u0628\u0631\u0627\u06c1 \u06a9\u0631\u0645 https:\/\/www.progeriaresearch.org\/meet-the-kids\/ \u067e\u0631 \u062c\u0627\u0626\u06cc\u06ba\u06d4<\/p>\n [3]<\/a> "\u0644\u0627\u0645\u06cc\u0646 \u0627\u06d2 \u0645\u06cc\u06ba \u0628\u0627\u0631 \u0628\u0627\u0631 \u06c1\u0648\u0646\u06d2 \u0648\u0627\u0644\u06d2 \u0688\u06cc \u0646\u0648\u0648 \u067e\u0648\u0627\u0626\u0646\u0679 \u06a9\u06cc \u062a\u0628\u062f\u06cc\u0644\u06cc \u06c1\u0686\u0646\u0633\u0646-\u06af\u0644\u0641\u0648\u0631\u0688 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0688\u0631\u0648\u0645 \u06a9\u06cc \u0648\u062c\u06c1 \u0633\u06d2\u060c" \u0641\u0637\u0631\u062a\u060c \u0648\u0627\u0644\u06cc\u0648\u0645\u06d4 423\u060c 15 \u0645\u0626\u06cc 2003\u06d4<\/p>\n [4]<\/a> 2021 \u0627\u0645\u0631\u06cc\u06a9\u0646 \u06c1\u0627\u0631\u0679 \u0627\u06cc\u0633\u0648\u0633\u06cc \u0627\u06cc\u0634\u0646 \u062f\u0644 \u06a9\u06cc \u0628\u06cc\u0645\u0627\u0631\u06cc \u0627\u0648\u0631 \u0641\u0627\u0644\u062c \u06a9\u06d2 \u0627\u0639\u062f\u0627\u062f\u0648\u0634\u0645\u0627\u0631\u06d4<\/p>\n [5]<\/a> \u06af\u0648\u0631\u0688\u0646 \u0627\u06cc\u0644 \u0628\u06cc\u060c \u06a9\u0644\u06cc\u0646 \u0645\u06cc\u0646 \u0627\u06cc\u0645 \u0627\u06cc\u060c \u0648\u063a\u06cc\u0631\u06c1\u06d4 \u06c1\u0686\u0646\u0633\u0646-\u06af\u0644\u0641\u0648\u0631\u0688 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0688\u0631\u0648\u0645 \u0648\u0627\u0644\u06d2 \u0628\u0686\u0648\u06ba \u0645\u06cc\u06ba \u0641\u0627\u0631\u0646\u06cc\u0633\u06cc\u0644 \u0679\u0631\u0627\u0646\u0633\u0641\u0631\u06cc\u0632 \u0631\u0648\u06a9\u0646\u06d2 \u0648\u0627\u0644\u06d2 \u06a9\u0627 \u06a9\u0644\u06cc\u0646\u06cc\u06a9\u0644 \u0679\u0631\u0627\u0626\u0644\u06d4 Proc Natl Acad Sci US A. \u0627\u06a9\u062a\u0648\u0628\u0631 2012 9;109(41):16666-71\u06d4 doi: 10.1073\/pnas.1202529109\u06d4 Epub 2012 \u0633\u062a\u0645\u0628\u0631 24\u06d4<\/p>\n [6]<\/a> Gordon LB\u060c Shappell H\u060c Massaro J\u060c et al. \u0627\u06cc\u0633\u0648\u0633\u06cc \u0627\u06cc\u0634\u0646 \u0622\u0641 \u0644\u0648\u0646\u0627\u0641\u0631\u0646\u06cc\u0628 \u0679\u0631\u06cc\u0679\u0645\u0646\u0679 \u0628\u0645\u0642\u0627\u0628\u0644\u06c1 \u06c1\u0686\u0646\u0633\u0646-\u06af\u0644\u0641\u0648\u0631\u0688 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0688\u0631\u0648\u0645 \u06a9\u06d2 \u0645\u0631\u06cc\u0636\u0648\u06ba \u0645\u06cc\u06ba \u0634\u0631\u062d \u0627\u0645\u0648\u0627\u062a \u06a9\u06d2 \u0633\u0627\u062a\u06be \u06a9\u0648\u0626\u06cc \u0639\u0644\u0627\u062c \u0646\u06c1\u06cc\u06ba\u06d4 \u062c\u0645\u0627 2018\u061b 319(16):1687\u20131695\u06d4<\/p>\n [7]<\/a>\u00a0Gordon, LB, Norris, W. Hamren, S.,\u00a0\u0648\u063a\u06cc\u0631\u06c1<\/em>. \u06c1\u0686\u0646\u0633\u0646-\u06af\u0644\u0641\u0648\u0631\u0688 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0688\u0631\u0648\u0645 \u06a9\u06d2 \u0645\u0631\u06cc\u0636\u0648\u06ba \u0645\u06cc\u06ba \u067e\u0644\u0627\u0632\u0645\u0627 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0646: \u0627\u0645\u06cc\u0648\u0646\u0648\u0633\u06d2 \u062a\u0631\u0642\u06cc \u0627\u0648\u0631 \u06a9\u0644\u06cc\u0646\u06cc\u06a9\u0644 \u062a\u0634\u062e\u06cc\u0635\u06d4\u00a0\u06af\u0631\u062f\u0634<\/em>, 2023.<\/p>\n [8]<\/a> \u06af\u0648\u0631\u0688\u0646 \u0627\u06cc\u0644 \u0628\u06cc\u060c \u0628\u0627\u0633\u0648 \u0627\u06cc\u0633\u060c \u0648\u063a\u06cc\u0631\u06c1\u06d4 \u06c1\u0686\u0646\u0633\u0646-\u06af\u0644\u0641\u0648\u0631\u0688 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0688\u0631\u0648\u0645 \u0645\u06cc\u06ba \u0627\u06c1\u0645 aortic stenosis \u06a9\u06d2 \u0644\u0626\u06d2 \u0645\u062f\u0627\u062e\u0644\u062a\u06d4\u00a0\u0633\u0627\u0645\u0646\u06d2 \u0648\u0627\u0644\u0627\u06d4 \u06a9\u0627\u0631\u0688\u06cc\u0648\u0627\u0633\u06a9\u06d4 \u0645\u06cc\u0688.<\/em>\u00a011:1356010\u06d4 doi: 10.3389\/fcvm.2024.1356010 (2024)\u06d4<\/p>\n [9]<\/a> Koblan, LW, Erdos, MR, Wilson, C. et al. Vivo \u0645\u06cc\u06ba \u0628\u06cc\u0633 \u0627\u06cc\u0688\u06cc\u0679\u0646\u06af \u0646\u06d2 \u0686\u0648\u06c1\u0648\u06ba \u0645\u06cc\u06ba \u06c1\u0686\u0646\u0633\u0646 \u2013 \u06af\u0644\u0641\u0648\u0631\u0688 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0688\u0631\u0648\u0645 \u06a9\u0648 \u0628\u0686\u0627\u06cc\u0627\u06d4 \u0641\u0637\u0631\u062a 589\u060c 608\u2013614 (2021)\u06d4<\/p>\n [10]<\/a> Erdos, MR, Cabral, WA, Tavarez, UL et al. \u06c1\u0686\u0646\u0633\u0646 \u2013 \u06af\u0644\u0641\u0648\u0631\u0688 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0688\u0631\u0648\u0645 \u06a9\u06d2 \u0644\u0626\u06d2 \u0627\u06cc\u06a9 \u0679\u0627\u0631\u06af\u0679\u0688 \u0627\u06cc\u0646\u0679\u06cc \u0633\u06cc\u0646\u0633 \u0639\u0644\u0627\u062c \u0645\u0639\u0627\u0644\u062c\u06c1\u06d4 \u0646\u06cc\u0679 \u0645\u06cc\u0688 (2021)\u06d4 https:\/\/doi.org\/10.1038\/s41591-021-01274-0<\/p>\n [11]<\/a> \u067e\u0679\u0627\u0631\u0627\u062c\u0648\u060c \u0627\u06cc\u0645\u060c \u062c\u06cc\u06a9\u0633\u0646\u060c \u0627\u06cc\u0645\u060c \u06a9\u0644\u06cc\u0646\u060c \u0627\u06cc\u0633 \u0648\u063a\u06cc\u0631\u06c1\u06d4 \u0645\u0646\u0638\u0645 \u0627\u0633\u06a9\u0631\u06cc\u0646\u0646\u06af \u06c1\u0686\u0646\u0633\u0646 \u2013 \u06af\u0644\u0641\u0648\u0631\u0688 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0688\u0631\u0648\u0645 \u06a9\u06d2 \u0644\u0626\u06d2 \u0639\u0644\u0627\u062c \u06a9\u06d2 \u0627\u06cc\u0646\u0679\u06cc \u0633\u06cc\u0646\u0633 \u0627\u0648\u0644\u06cc\u06af\u0648\u0646\u0648\u06a9\u0644\u06cc\u0648\u0679\u0627\u0626\u0688\u0633 \u06a9\u06cc \u0634\u0646\u0627\u062e\u062a \u06a9\u0631\u062a\u06cc \u06c1\u06d2\u06d4 \u0646\u06cc\u0679 \u0645\u06cc\u0688 (2021)\u06d4 https:\/\/doi.org\/10.1038\/s41591-021-01262-4<\/p>\n [12]<\/a> \u06a9\u0627\u0646\u06af \u0627\u06cc\u0633 \u0627\u06cc\u0645\u060c \u06cc\u0648\u0646 \u0627\u06cc\u0645 \u0627\u06cc\u0686\u060c \u0648\u063a\u06cc\u0631\u06c1\u06d4 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0646\u0646\u060c \u0627\u06cc\u06a9 \u0628\u06c1\u062a\u0631\u06cc\u0646 \u067e\u0631\u0648\u062c\u06cc\u0631\u0646-\u0644\u0627\u0645\u06cc\u0646 \u0627\u06cc\u06a9 \u0628\u0627\u0626\u0646\u0688\u0646\u06af \u0631\u0648\u06a9\u0646\u06d2 \u0648\u0627\u0644\u0627\u060c \u06c1\u0686\u0646\u0633\u0646-\u06af\u0644\u0641\u0648\u0631\u0688 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0688\u0631\u0648\u0645 \u06a9\u06d2 \u0642\u0628\u0644 \u0627\u0632 \u0648\u0642\u062a \u0633\u0646\u0633\u0646\u06cc \u06a9\u06d2 \u0641\u06cc\u0646\u0648\u0679\u0627\u0626\u067e\u0633 \u06a9\u0648 \u06a9\u0645 \u06a9\u0631\u062a\u0627 \u06c1\u06d2\u06d4 Commun Biol<\/em>. 2021 \u062c\u0646\u0648\u0631\u06cc 4; 4(1):5\u06d4<\/a><\/p>\n [13]<\/a> \u06af\u0648\u0631\u0688\u0646\u060c \u0627\u06cc\u0644 \u0628\u06cc\u060c \u0646\u0648\u0631\u0633\u060c \u0688\u0628\u0644\u06cc\u0648\u060c \u062d\u0645\u0631\u06cc\u0646\u060c \u0627\u06cc\u0633\u060c \u0648\u063a\u06cc\u0631\u06c1\u06d4 \u06c1\u0686\u0646\u0633\u0646-\u06af\u0644\u0641\u0648\u0631\u0688 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0633\u0646\u0688\u0631\u0648\u0645 \u06a9\u06d2 \u0645\u0631\u06cc\u0636\u0648\u06ba \u0645\u06cc\u06ba \u067e\u0644\u0627\u0632\u0645\u0627 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0646: \u0627\u0645\u06cc\u0648\u0646\u0648\u0633\u06d2 \u062a\u0631\u0642\u06cc \u0627\u0648\u0631 \u06a9\u0644\u06cc\u0646\u06cc\u06a9\u0644 \u062a\u0634\u062e\u06cc\u0635\u06d4 \u06af\u0631\u062f\u0634<\/em>, 2023<\/p>\n [\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][\/et_pb_section] custom_margin="-2px|||||" custom_padding=\u201d0|0px|0|0px|false|false\u201d z_index_tablet=\u201d500\u2033 \u0628\u0627\u0631\u0688\u0631_width_top=\u201d12px\u201d \u0628\u0627\u0631\u0688\u0631_color_top=\u201d#00b2e2\u2033 global_module=\u201d133\u2033 locked=\u201doff\u201d global_colors_info=\u201d[global_colors_info] column_structure=\u201d1_3,1_3,1_3\u2033 disabled_on=\u201don|on|on\u201d _builder_version=\u201d4.21.0\u2033 _module_preset=\u201ddefault\u201d min_height=\u201d277px\u201d custom_margin=\u201d|20px|30px|false\u201d|false custom_padding="0px|30px|0px||false|false" disabled="on"global_colors_info="{}"][et_pb_column_inner type="1_3\u2033 saved_specialty_column_type="3_4\u2033 _builder\u2033_version="_preset ="4. global_colors_info="{}"][et_pb_image src="https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2023\/08\/Startbanner-1.png" title_text="Startbanner" url="https:\/\/ www.gravoc.com\/\u201d align=\u201dright\u201d _builder_version=\u201d4.21.0\u2033 _module_preset="default" custom_margin="|-50px||20px|false|false" global_colors_info="{}"][\/et_pb_image][\/et_pb_column_inner][et_pb_column_inner type="1_3\u2033column_type="1_3\u2033column_type="1_3\u2033 \u0645\u062d\u0641\u0648\u0638 \u0634\u062f\u06c1_spex _builder_version=\u201d4.21.0\u2033 _module_preset=\u201ddefault\u201d global_colors_info=\u201d{}\u201d][\/et_pb_column_inner][et_pb_column_inner type=\u201d1_3\u2033 saved_specialty_column_type=\u201d3\u2033_4\u2033 ion. _module_preset="default" global_colors_info="{}"][et_pb_image src="https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2023\/07\/RFRFinish.png" title_text="RFRFinish" _builder_vers. .0\u2033 _module_preset=\u201ddefault\u201d custom_margin=\u201d|20px||-50px|false|false\u201d global_colors_info=\u201d{}\u201d][\/et_pb_image][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row\u2033 \u06a9\u0627\u0644\u0645_1=4, 1_1=4} make_equal="on" module_class="et_pb_row_fullwidth" _builder_version="4.16\u2033 width="89%" width_tablet="80%" width_phone="" width_last_edited="on"|desktop 9"Twidth="Twidth="8TP max_width_tablet=\u201d80%\u201d max_width_phone=\u201d\u201dmax_width_last_edited=\u201don|desktop\u201d z_index_tablet=\u201d500\u2033 make_fullwidth=\u201don\u201d width_unit=\u201doff\u201d custom_width_percent=\u201d1001 global_colors_info=\u201d{}\u201d][et_pb_column type=\u201d1_4\u2033 _builder_version=\u201d4.16\u2033 custom_padding=\u201d|||\u201d global_colors_info="{}" custom_padding__hover="|||"][et_pb_cta button_url="https:\/\/www.progeriaresearch.org\/newsletter-signup\/" button_text="\u0627\u0628\u06be\u06cc \u0633\u0627\u0626\u0646 \u0627\u067e \u06a9\u0631\u06cc\u06ba" admin_label="\u0646\u06cc\u0648\u0632 \u0644\u06cc\u0679\u0631 \u06a9\u06d2 \u0644\u0626\u06d2 \u0633\u0627\u0626\u0646 \u0627\u067e \u06a9\u0631\u06cc\u06ba" \u0645\u0627\u0688\u06cc\u0648\u0644_\u06a9\u0644\u0627\u0633 =\u201dsign-btn\u201d _builder_version=\u201d4.16\u2033 header_font_size=\u201d25px\u201d background_color=\u201d#29327a\u201d animation_style=\u201dslide\u201d animation_direction=\u201dleft\u201d animation_intensity_slide=\u201d25%\u201d header_font_size_tablet=\u201d\u201d header_font_size_phone=\u201d30p header_font_size_last_edited=\u201don|desktop\u201d z_index_tablet=\u201d500\u2033 border_radii=\u201don|25px|25px|25px|25px\u201d global_colors_info=\u201d{}\u201d button_bg_color__hover_enabled=\u201don\u201d or TP_tverg=\u201dcolored_b8\u201d button_border_color__hover_enabled="\u0622\u0646"]<\/p>\n [\/et_pb_cta][\/et_pb_column][et_pb_column type=\u201d1_4\u2033 _builder_version=\u201d4.16\u2033 custom_padding=\u201d|||\u201d global_colors_info=\u201d{}\u201d custom_padding__hover=\u201d|||\u201d][et_pb_cta button_url=\u201dhttps:\/\/progeriaresearch.donorsupport.co\/-\/XZHJVWZR\u201d button_text=\u201d\u0627\u0628\u06be\u06cc \u0639\u0637\u06cc\u06c1 \u06a9\u0631\u06cc\u06ba\u201d admin_label=\u201d\u0627\u06cc\u06a9 \u0633\u0627\u062a\u06be \u0645\u0644 \u06a9\u0631\u060c \u06c1\u0645 \u0639\u0644\u0627\u062c \u062a\u0644\u0627\u0634 \u06a9\u0631\u06cc\u06ba \u06af\u06d2! 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After an initial clinical evaluation (looking at the child\u2019s appearance and medical records), a sample of the child\u2019s blood will be tested for Progeria.\u00a0 PRF provides a definitive, scientific way to diagnose the children.<\/em> This leads to more accurate and earlier diagnoses so the children can receive proper care.<\/p>\r\n[\/vc_column_text][vc_column_text css=\".vc_custom_1555429336142{background-color: #ffffff !important;}\"]\r\n![\"\"](\"https:\/\/www.progeriaresearch.org\/assets\/images\/medical_images\/progeria-cell.jpg\")
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What is Progeria?<\/h1>\r\n
Did you know?<\/h1>\r\n
How common is Progeria?<\/h1>\r\nProgeria affects approximately 1 in 20 million people.\u00a0 There are an estimated 350-400 children living with Progeria worldwide at any one time.\u00a0 It affects both sexes equally and all races.\u00a0 Since The Progeria Research Foundation was created in 1999, we have discovered children with Progeria living in 52 countries and speaking 32 languages.\r\n\r\nFor a map of where living children reside, please go to our Meet the Kids<\/a> page.[\/vc_column_text][vc_column_text]\r\n
What are the features of Progeria?<\/h1>\r\nAlthough they are usually born looking healthy, most children with Progeria begin to display many characteristics of Progeria within the first 2 years of life.\u00a0 Signs of Progeria include growth failure, loss of body fat and hair, aged-looking skin and stiffness of joints.\u00a0 As children get older, they suffer from atherosclerosis, cardiovascular (heart) disease and sometimes have strokes.\u00a0 The children have a remarkably similar appearance despite differing ethnic backgrounds. Children with Progeria die of heart failure at an average age of fourteen years.[\/vc_column_text][vc_column_text]\r\n
What is the cause of Progeria?<\/h1>\r\n[caption id=\"\" align=\"alignnone\" width=\"142\"]
Progeria Cell Nucleus.[\/caption]\r\n\r\nHGPS is caused by a mutation in the gene called LMNA<\/em> (pronounced \u201clamin-a\u201d). The LMNA<\/em> gene produces the lamin A protein which is the structural scaffolding that holds the nucleus of a cell together. The abnormal lamin A protein that causes Progeria is called progerin<\/em>.\u00a0 Progerin makes the nucleus unstable.\u00a0 That cellular instability leads to the process of premature aging and disease in Progeria.\r\n\r\nPRF was the driving force behind finding the gene responsible for Progeria. A group of leading scientists from PRF\u2019s Genetics Consortium was able to isolate the Progeria gene, and in April 2003, PRF led the announcement reported in the top scientific journal Nature<\/em>v<\/a>.\r\n\r\n\u201cIsolating the Progeria gene is a major achievement for the medical research community,\u201d<\/em> said Dr. Francis Collins, Director of the National Institutes of Health and senior discoverer of the Progeria gene, \u201cThe discovery not only gives hope to children and families affected by<\/em>\r\n\r\nProgeria, but also may shed light on the phenomenon of aging and cardiovascular disease.\u201d<\/em>\r\n\r\nv<\/a> \u201cRecurrent de novo point mutations in lamin A cause Hutchinson-Gilford Progeria Syndrome\u201d, \u00a0Nature<\/em>, \u00a0Vol. 423, \u00a0May 15, 2003.[\/vc_column_text][vc_column_text]\r\nWhat does Progeria have to do with aging?<\/h1>\r\nWe now know that there is a biological overlap between children with Progeria and the general aging population.\u00a0 We all make a little bit of progerin<\/em>, the disease-causing protein in Progeria. We make much less progerin than children with Progeria, but the progerin builds up over a lifetime and may be partly responsible for aspects of aging such as atherosclerosis.\u00a0 Progerin is also linked to telomere dysfunction.\u00a0 Telomeres are proteins that play a major role in cellular aging.\r\n\r\nChildren with Progeria are genetically predisposed to premature, progressive heart disease. Death occurs almost exclusively due to widespread heart disease, the leading cause of death worldwide.+<\/a>\u00a0 Thus, there is clearly a tremendous need for research in Progeria.\u00a0 Finding a cure for Progeria will not only help these children, but may provide keys for treating millions of adults with heart disease and stroke associated with the natural aging process.\r\n\r\n\u00a0<\/strong>+<\/a> \u00a02016 American Heart Association Heart Disease and Stroke Statistics[\/vc_column_text][vc_column_text css=\".vc_custom_1495542400027{background-color: #ffffff !important;}\"]\r\n
Is Progeria passed down from parent to child?<\/h1>\r\nHGPS is not usually passed down in families. The gene change is almost always a chance occurrence that is extremely rare. Children with other types of \u201cprogeroid\u201d syndromes which are not HGPS may have diseases that are passed down in families. However, HGPS is a \u201csporadic autosomal dominant\u201d mutation \u2013 sporadic because it is a new change in that family, and dominant because only one copy of the gene needs to be changed in order to have the syndrome. For parents who have never had a child with Progeria, the chances of having a child with Progeria are 1 in 20 million. But for parents who have already had a child with Progeria, the chances of it happening again to those parents is much higher \u2013 about 2-3%. Why the increase? This is due to a condition called \u201cmosaicism\u201d, where a parent has the genetic mutation for Progeria in a small proportion of their cells, but does not have Progeria. Prenatal testing is available to look for the LMNA <\/em>genetic change that causes HGPS.[\/vc_column_text][vc_column_text css=\".vc_custom_1508524802591{background-color: #ffffff !important;}\"]\r\n
How is Progeria diagnosed?<\/h1>\r\n
What is PRF doing to help children with Progeria?<\/h1>\r\n
PRF is also driving Progeria clinical drug trials testing potential treatments.\u00a0 To date, PRF has funded and co-coordinated three clinical trials. Please refer to our clinical drug trials <\/strong><\/a>section for more details.\u00a0History was made in September 2012 with the discovery that the drug involved in the first clinical trial, a farnesyltransferase inhibitor or FTI , is the first-ever treatment for Progeria \u2666.\u00a0 PRF continues to explore other promising drugs that will bring us to a cure for Progeria. \u00a0<\/strong>The Progeria Research Foundation funds medical research aimed at developing treatments and a cure for Progeria.\u00a0 PRF also has its own Cell & Tissue Bank<\/strong><\/a> that provides the biological materials researchers need to conduct their experiments.\u00a0 Additionally, PRF has established a Medical & Research Database<\/strong><\/a> to supply physicians and families with medical recommendations for cardiac care, nutrition and other medical issues to help children and adults with Progeria have a better quality of life.\u00a0 We continue to analyze medical records of children and adults with Progeria so that we can provide information on how best to medically help those with Progeria, and provide clues towards potential new treatments.\u00a0 PRF \u00a0has also published