{"id":8398,"date":"2020-11-02T18:57:17","date_gmt":"2020-11-02T23:57:17","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?p=8398"},"modified":"2022-12-09T06:43:20","modified_gmt":"2022-12-09T11:43:20","slug":"2020-workshop","status":"publish","type":"post","link":"https:\/\/www.progeriaresearch.org\/ur\/2020\/11\/02\/2020-workshop\/","title":{"rendered":"PRF \u06a9\u06cc 10\u0648\u06cc\u06ba \u0628\u06cc\u0646 \u0627\u0644\u0627\u0642\u0648\u0627\u0645\u06cc \u0633\u0627\u0626\u0646\u0633\u06cc \u0648\u0631\u06a9\u0634\u0627\u067e"},"content":{"rendered":"

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370 \u0633\u06d2 \u0632\u06cc\u0627\u062f\u06c1<\/strong> \u0633\u06d2 \u0631\u062c\u0633\u0679\u0631 \u06a9\u0631\u0646\u06d2 \u0648\u0627\u0644\u0648\u06ba 30<\/strong> \u0645\u0645\u0627\u0644\u06a9 \u0646\u06d2 \u06c1\u0645\u0627\u0631\u06d2 1 \u0645\u06cc\u06ba \u0634\u0631\u06a9\u062a \u06a9\u06cc\u06d4st<\/sup> \u06a9\u0628\u06be\u06cc \u0648\u06cc\u0628 \u067e\u0631 \u0645\u0628\u0646\u06cc \u0633\u0627\u0626\u0646\u0633\u06cc \u0645\u06cc\u0679\u0646\u06af!<\/h4>\n

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\u06c1\u0645 \u0627\u0645\u06cc\u062f \u06a9\u0631\u062a\u06d2 \u06c1\u06cc\u06ba \u06a9\u06c1 \u0622\u067e \u06c1\u0645\u0627\u0631\u06cc 2020 \u0628\u06cc\u0646 \u0627\u0644\u0627\u0642\u0648\u0627\u0645\u06cc \u0648\u0631\u06a9\u0634\u0627\u067e \u0633\u06d2 \u0627\u0633 \u06a9\u0644\u067e \u0633\u06d2 \u0644\u0637\u0641 \u0627\u0646\u062f\u0648\u0632 \u06c1\u0648\u06ba \u06af\u06d2\u060c
"\u062a\u062d\u0642\u06cc\u0642 \u06a9\u06d2 \u0627\u0645\u06a9\u0627\u0646\u0627\u062a\u060c \u0632\u0646\u062f\u06af\u06cc\u0648\u06ba \u06a9\u0648 \u0628\u0691\u06be\u0627\u0646\u0627" \u0648\u06cc\u0628\u06cc\u0646\u0627\u0631<\/h4>\n

[\/et_pb_text][et_pb_video src=”https:\/\/www.youtube.com\/watch?v=pedD1zXVw1o&feature=youtu.be” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_video][et_pb_text admin_label=”disclaimer” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

\u00a0\u062c\u0645\u0644\u06c1 \u062d\u0642\u0648\u0642 \u0645\u062d\u0641\u0648\u0638 \u06c1\u06cc\u06ba\u06d4 \u0628\u0631\u0627\u06c1 \u06a9\u0631\u0645 \u06a9\u0633\u06cc \u0628\u06be\u06cc \u0637\u0631\u062d \u0633\u06d2 \u0627\u0633 \u067e\u06cc\u0634\u06a9\u0634 \u06a9\u0648 \u0688\u0627\u0624\u0646 \u0644\u0648\u0688\u060c \u06a9\u0627\u067e\u06cc\u060c \u062a\u0642\u0633\u06cc\u0645 \u06cc\u0627 \u062a\u0631\u0645\u06cc\u0645 \u0646\u06c1 \u06a9\u0631\u06cc\u06ba\u06d4<\/i><\/p>\n

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\u063a\u06cc\u0631 \u062c\u0648\u0627\u0628\u06cc \u0686\u06cc\u0679 \u0633\u0648\u0627\u0644\u0627\u062a<\/strong><\/h4>\n

[\/et_pb_text][et_pb_toggle title=”To Dr. Francis Collins: Question: From Mansoor Amiji: Dr. Collins, have you looked at the biodistribution of the PPPMO upon systemic ” open_toggle_background_color=”#f7f7f7″ closed_toggle_text_color=”#ffffff” closed_toggle_background_color=”#00b2e2″ icon_color=”#ffc15e” open_icon_color=”#ffc15e” admin_label=”Collins Q&A” _builder_version=”4.16″ _module_preset=”default” title_text_color=”#00b2e2″ title_font=”||||||||” background_color=”#ffffff” custom_margin=”||25px” custom_padding=”|50px||50px||true” border_width_all=”0px” global_colors_info=”{}”]<\/p>\n


\"\"\u062c\u0648\u0627\u0628:<\/strong> PK\/PD \u0645\u0637\u0627\u0644\u0639\u06c1 \u062f\u0644\u060c \u0634\u06c1 \u0631\u06af \u0627\u0648\u0631 \u06af\u0631\u062f\u06d2 \u0645\u06cc\u06ba 100% \u062c\u06cc\u0648 \u062f\u0633\u062a\u06cc\u0627\u0628\u06cc \u06a9\u06cc \u0646\u0634\u0627\u0646\u062f\u06c1\u06cc \u06a9\u0631\u062a\u0627 \u06c1\u06d2\u06d4 \u06af\u0631\u062f\u06d2 \u0648\u0627\u062d\u062f \u0679\u0634\u0648 \u062a\u06be\u0627 \u062c\u06c1\u0627\u06ba \u06c1\u0633\u0679\u0648\u0644\u0648\u062c\u06a9 \u0627\u0645\u062a\u062d\u0627\u0646 \u0627\u0648\u0631 PK\/PD \u0688\u06cc\u0679\u0627 \u06a9\u06cc \u0628\u0646\u06cc\u0627\u062f \u067e\u0631 \u062c\u0645\u0639 \u06c1\u0648\u0646\u06d2 \u06a9\u06cc \u062a\u062c\u0648\u06cc\u0632 \u062a\u06be\u06cc\u06d4 SRP-2001 \u06a9\u06cc \u0648\u0627\u062d\u062f \u062e\u0648\u0631\u0627\u06a9 \u06a9\u06cc \u0627\u0646\u062a\u0638\u0627\u0645\u06cc\u06c1 \u0646\u06d2 \u06cc\u06c1 \u0638\u0627\u06c1\u0631 \u06a9\u06cc\u0627 \u06a9\u06c1 PPMO \u062f\u0644 \u0633\u06d2 \u062a\u06cc\u0632\u06cc \u0633\u06d2 \u0635\u0627\u0641 \u06c1\u0648 \u06af\u06cc\u0627 (2 \u06af\u06be\u0646\u0679\u06d2 \u06a9\u06d2 \u0627\u0646\u062f\u0631)\u060c \u0634\u06c1 \u0631\u06af \u0633\u06d2 4 \u06af\u06be\u0646\u0679\u06d2 \u06a9\u06d2 \u0627\u0646\u062f\u0631 \u0635\u0627\u0641 \u06c1\u0648 \u06af\u06cc\u0627\u060c \u0644\u06cc\u06a9\u0646 \u06af\u0631\u062f\u06d2 \u0645\u06cc\u06ba 48 \u06af\u06be\u0646\u0679\u06d2 \u06a9\u06d2 \u0679\u0627\u0626\u0645 \u067e\u0648\u0627\u0626\u0646\u0679 \u062a\u06a9 \u0628\u0631\u0642\u0631\u0627\u0631 \u0631\u06c1\u0627\u06d4 \u0645\u0642\u062f\u0627\u0631\u06cc ddPCR \u0646\u06d2 \u062a\u0645\u0627\u0645 \u0679\u0634\u0648\u0632 \u0645\u06cc\u06ba G608G \u06a9\u0631\u06cc\u067e\u0679\u06a9 \u0633\u067e\u0644\u0627\u0626\u0633 \u06a9\u06cc \u0631\u0648\u06a9 \u062a\u06be\u0627\u0645 \u06a9\u06cc \u0633\u0631\u06af\u0631\u0645\u06cc \u06a9\u0627 \u0645\u0638\u0627\u06c1\u0631\u06c1 \u06a9\u06cc\u0627 \u0633\u0648\u0627\u0626\u06d2 \u062c\u0644\u062f \u06a9\u06d2 \u062c\u0633 \u06a9\u0627 \u0627\u0628 \u062a\u06a9 \u062a\u062c\u0631\u0628\u06c1 \u06a9\u06cc\u0627 \u06af\u06cc\u0627 \u06c1\u06d2 (\u0634\u06c1 \u0631\u06af\u060c \u062f\u0644\u060c \u06af\u0631\u062f\u06d2\u060c \u062c\u06af\u0631\u060c \u06a9\u0648\u0627\u0688\u0631\u06cc\u0633\u06cc\u067e\u0633\u060c \u06c1\u0688\u06cc)\u060c \u062d\u0627\u0644\u0627\u0646\u06a9\u06c1 \u0633\u0631\u06af\u0631\u0645\u06cc \u0679\u0634\u0648 \u06a9\u06d2 \u0644\u062d\u0627\u0638 \u0633\u06d2 \u0645\u062e\u062a\u0644\u0641 \u06c1\u0648\u062a\u06cc \u06c1\u06d2\u06d4<\/p>\n

\u0641\u0631\u0627\u0646\u0633\u0633\u060c \u0645\u0627\u0626\u06cc\u06a9\u060c \u0627\u0648\u0631 \u0648\u06cc\u0646<\/em><\/p>\n

[\/et_pb_toggle][et_pb_toggle title=”To Dr. Pinak Shah and Dr. Francesco Musumeci: Question: From RVB: Can magnesium\/calcium intake determine the degree of calcification in children with HGPS?” open_toggle_background_color=”#f7f7f7″ closed_toggle_text_color=”#ffffff” closed_toggle_background_color=”#00b2e2″ icon_color=”#ffc15e” open_icon_color=”#ffc15e” admin_label=”Shah & Musumeci Q&A” _builder_version=”4.16″ _module_preset=”default” title_text_color=”#00b2e2″ title_font=”||||||||” background_color=”#ffffff” custom_margin=”||25px” custom_padding=”|50px||50px||true” border_width_all=”0px” global_colors_info=”{}”]<\/p>\n

\"\"<\/strong>\u062c\u0648\u0627\u0628:<\/strong>\u0633\u0648\u0627\u0644 \u06a9\u06d2 \u0628\u0627\u0631\u06d2 \u0645\u06cc\u06ba\u060c \u0633\u0686 \u067e\u0648\u0686\u06be\u06cc\u06ba \u062a\u0648\u060c \u0645\u062c\u06be\u06d2 \u0627\u0633 \u0633\u0648\u0627\u0644 \u06a9\u0627 \u062c\u0648\u0627\u0628 \u0646\u06c1\u06cc\u06ba \u0645\u0639\u0644\u0648\u0645\u06d4 \u062a\u0627\u06c1\u0645\u060c \u0627\u06cc\u06a9 \u0639\u0627\u0645 \u0628\u0627\u0644\u063a \u0645\u06cc\u06ba\u060c \u06c1\u0645 \u0648\u0627\u0644\u0648\u0648\u0644\u0631 \u06a9\u06cc\u0644\u06a9\u06cc\u0641\u06cc\u06a9\u06cc\u0634\u0646 \u06a9\u06cc \u0688\u06af\u0631\u06cc \u06a9\u0648 Mg\/Ca \u06a9\u06cc \u0645\u0642\u062f\u0627\u0631 \u0633\u06d2 \u0646\u06c1\u06cc\u06ba \u062c\u0648\u0691\u062a\u06d2 \u06c1\u06cc\u06ba\u060c \u0628\u06be\u0627\u0631\u06cc \u06a9\u06cc\u0644\u06a9\u06cc\u0641\u06cc\u06a9\u06cc\u0634\u0646 \u06a9\u0627 \u0627\u0645\u06a9\u0627\u0646 \u062f\u06cc\u06af\u0631 \u0639\u0648\u0627\u0645\u0644 \u06a9\u06cc \u0648\u062c\u06c1 \u0633\u06d2 \u06c1\u0648\u062a\u0627 \u06c1\u06d2\u06d4<\/p>\n

\u0688\u0627\u06a9\u0679\u0631 \u067e\u0646\u06a9 \u0634\u0627\u06c1<\/em><\/p>\n

 <\/p>\n

 <\/p>\n

\"\"\u062c\u0648\u0627\u0628: <\/strong>\u0645\u06cc\u06ba \u0688\u0627\u06a9\u0679\u0631 \u0634\u0627\u06c1 \u06a9\u06cc \u0631\u0627\u0626\u06d2 \u0633\u06d2 \u0645\u062a\u0641\u0642 \u06c1\u0648\u06ba\u06d4 \u0645\u0645\u06a9\u0646\u06c1 \u0637\u0648\u0631 \u067e\u0631 HGPS \u0645\u06cc\u06ba \u0648\u0627\u0644\u0648 \u06a9\u06cc\u0644\u0633\u06cc\u0641\u06cc\u06a9\u06cc\u0634\u0646 \u06a9\u06cc \u0648\u062c\u0648\u06c1\u0627\u062a \u0627\u0633 \u0633\u06d2 \u0645\u062e\u062a\u0644\u0641 \u06c1\u06cc\u06ba \u062c\u0648 \u06c1\u0645 \u0628\u0648\u0691\u06be\u06d2 \u0645\u0631\u06cc\u0636\u0648\u06ba \u0645\u06cc\u06ba \u062f\u06cc\u06a9\u06be\u062a\u06d2 \u06c1\u06cc\u06ba\u06d4 \u0645\u062c\u06be\u06d2 Ca \u0627\u0648\u0631 Mg \u0645\u06cc\u0679\u0627\u0628\u0648\u0644\u0632\u0645 \u06a9\u06d2 \u0628\u0627\u0631\u06d2 \u0645\u06cc\u06ba \u0628\u06be\u06cc \u06a9\u0648\u0626\u06cc \u0639\u0644\u0645 \u0646\u06c1\u06cc\u06ba \u06c1\u06d2\u06d4<\/p>\n

\u0688\u0627\u06a9\u0679\u0631 \u0641\u0631\u0627\u0646\u0633\u0633\u06a9\u0648 \u0645\u06cc\u0648\u0632\u06cc\u0645\u06cc\u0633\u06cc<\/em><\/p>\n

\u00a0<\/strong><\/p>\n

[\/et_pb_toggle][et_pb_toggle title=” To Dr. Vicente Andres: Question: From Andre Monteiro Da Rocha – University of Michigan: Do the mice lacking Lamin A develop DCM?” open_toggle_background_color=”#f7f7f7″ closed_toggle_text_color=”#ffffff” closed_toggle_background_color=”#00b2e2″ icon_color=”#ffc15e” open_icon_color=”#ffc15e” admin_label=”Andres Q&A” _builder_version=”4.16″ _module_preset=”default” title_text_color=”#00b2e2″ title_font=”||||||||” background_color=”#ffffff” custom_margin=”||25px” custom_padding=”|50px||50px||true” border_width_all=”0px” global_colors_info=”{}”]<\/p>\n

\"\"\u062c\u0648\u0627\u0628: <\/strong>\u0644\u0627\u0645\u06cc\u0646 A\/C null (Lmna<\/em>-\/-<\/sup>) \u0645\u0627\u0624\u0633 \u0645\u0627\u0688\u0644 DCM \u062a\u06cc\u0627\u0631 \u06a9\u0631\u062a\u0627 \u06c1\u06d2 \u062c\u0633 \u06a9\u06d2 \u0633\u0627\u062a\u06be \u06a9\u0627\u0631\u0688\u06cc\u06a9 \u0641\u0646\u06a9\u0634\u0646 \u06a9\u0627 \u0646\u0642\u0635\u0627\u0646 \u06c1\u0648\u062a\u0627 \u06c1\u06d2\u06d4 \u0645\u0632\u06cc\u062f \u06cc\u06c1 \u06a9\u06c1\u060c \u06cc\u06c1 \u0686\u0648\u06c1\u06d2 \u062f\u0644 \u06a9\u06cc \u062a\u0631\u0633\u06cc\u0644 \u0627\u0648\u0631 \u0648\u0633\u06cc\u0639 \u06a9\u0627\u0631\u0688\u06cc\u06a9 \u0641\u0627\u0626\u0628\u0631\u0648\u0633\u0633 \u0645\u06cc\u06ba \u0646\u0642\u0627\u0626\u0635 \u0638\u0627\u06c1\u0631 \u06a9\u0631\u062a\u06d2 \u06c1\u06cc\u06ba\u060c \u0627\u0648\u0631 5-8 \u06c1\u0641\u062a\u0648\u06ba \u06a9\u06cc \u0639\u0645\u0631 \u0645\u06cc\u06ba \u0642\u0628\u0644 \u0627\u0632 \u0648\u0642\u062a \u0645\u0648\u062a (\u0627\u06af\u0633\u062a \u0627\u06cc\u0679 \u0627\u0644\u06d4\u060c 2018\u061b \u0641\u0631\u0627\u06a9 \u0627\u06cc\u0679 \u0627\u0644\u06d4\u060c 2012\u061b \u0633\u0644\u06cc\u0648\u0627\u0646\u060c 1999)\u06d4 \u062a\u0627\u06c1\u0645\u060c \u0645\u0627\u0624\u0633 \u06a9\u06d2 \u0645\u0627\u0688\u0644\u0632 \u062c\u0646 \u0645\u06cc\u06ba \u0635\u0631\u0641 Lamin A (Fong et al., 2006) \u06cc\u0627 lamin C (Coffinier et al., 2010) \u06a9\u06cc \u06a9\u0645\u06cc \u06c1\u0648\u062a\u06cc \u06c1\u06d2 \u0648\u06c1 \u0642\u0644\u0628\u06cc \u0646\u0642\u0627\u0626\u0635 \u0646\u06c1\u06cc\u06ba \u062f\u06a9\u06be\u0627\u062a\u06d2 \u06c1\u06cc\u06ba \u0627\u0648\u0631 \u0627\u0646 \u06a9\u06cc \u0639\u0645\u0631 \u0639\u0627\u0645 \u06c1\u0648\u062a\u06cc \u06c1\u06d2\u06d4<\/p>\n

\u062d\u0648\u0627\u0644\u06c1 \u062c\u0627\u062a:
<\/strong>Auguste, G., Gurha, P., Lombardi, R., Coarfa, C., Willerson, JT, & Marian, AJ (2018)\u06d4 \u062f\u0644 \u0645\u06cc\u06ba \u0641\u0639\u0627\u0644 FOXO \u0679\u0631\u0627\u0646\u0633\u06a9\u0631\u067e\u0634\u0646 \u0639\u0648\u0627\u0645\u0644 \u06a9\u0648 \u062f\u0628\u0627\u0646\u0627 \u0644\u06cc\u0645\u06cc\u0646\u0648\u067e\u06cc\u062a\u06be\u06cc\u0632 \u06a9\u06d2 \u0645\u0627\u0624\u0633 \u0645\u0627\u0688\u0644 \u0645\u06cc\u06ba \u0628\u0642\u0627 \u06a9\u0648 \u0637\u0648\u0644 \u062f\u06cc\u062a\u0627 \u06c1\u06d2\u06d4<\/em>. https:\/\/doi.org\/10.1161\/CIRCRESAHA.117.312052<\/a><\/p>\n

Coffinier, C., Jung, HJ, Li, Z., Nobumori, C., Yun, UJ, Farber, EA, Davies, BS, Weinstein, MM, Yang, SH, Lammerding, J., Farahani, JN, Bentolila, LA, Fong, LG, & Young, SG (2010)\u06d4 lamin A \u06a9\u06cc \u0628\u0631\u0627\u06c1 \u0631\u0627\u0633\u062a \u062a\u0631\u06a9\u06cc\u0628\u060c prelamin a \u067e\u0631\u0648\u0633\u06cc\u0633\u0646\u06af \u06a9\u0648 \u0646\u0638\u0631\u0627\u0646\u062f\u0627\u0632 \u06a9\u0631\u062a\u06d2 \u06c1\u0648\u0626\u06d2\u060c fibroblasts \u0645\u06cc\u06ba misshapen nuclei \u06a9\u0627 \u0633\u0628\u0628 \u0628\u0646\u062a\u06cc \u06c1\u06d2 \u0644\u06cc\u06a9\u0646 \u0686\u0648\u06c1\u0648\u06ba \u0645\u06cc\u06ba \u06a9\u0648\u0626\u06cc \u0642\u0627\u0628\u0644 \u0634\u0646\u0627\u062e\u062a \u067e\u06cc\u062a\u06be\u0627\u0644\u0648\u062c\u06cc \u0646\u06c1\u06cc\u06ba \u06c1\u06d2\u06d4 \u062d\u06cc\u0627\u062a\u06cc\u0627\u062a\u06cc \u06a9\u06cc\u0645\u0633\u0679\u0631\u06cc \u06a9\u0627 \u062c\u0631\u0646\u0644<\/em>, 285<\/em>(27)\u060c 20818\u201320826\u06d4 https:\/\/doi.org\/10.1074\/jbc.M110.128835<\/a><\/p>\n

Fong, LG, Bergo, MO, Young, SG, Fong, LG, Ng, JK, Lammerding, J., Vickers, TA, Meta, M., Cot\u00e9, N., Gavino, B., Qiao, X., Chang , SY, Young, SR, Yang, SH, Stewart, CL, Lee, RT, Bennett, CF, Bergo, MO, & Young, \u0627\u06cc\u0633 \u062c\u06cc (2006)\u06d4 Prelamin A \u0627\u0648\u0631 lamin A \u062c\u0648\u06c1\u0631\u06cc \u0644\u0627\u0645\u06cc\u0646\u0627 \u0645\u06cc\u06ba \u0642\u0627\u0628\u0644\u0650 \u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u062f\u06a9\u06be\u0627\u0626\u06cc \u062f\u06cc\u062a\u06d2 \u06c1\u06cc\u06ba\u06d4 \u062c\u0631\u0646\u0644 \u0622\u0641 \u06a9\u0644\u06cc\u0646\u06cc\u06a9\u0644 \u0627\u0646\u0648\u06cc\u0633\u0679\u06cc \u06af\u06cc\u0634\u0646<\/em>, 116<\/em>(3)\u060c 743\u2013752\u06d4 https:\/\/doi.org\/10.1172\/JCI27125.with<\/a><\/p>\n

\u0641\u0631\u0627\u06a9\u060c \u0622\u0631 \u0627\u06cc\u0644\u060c \u0686\u0646\u060c \u0627\u06cc\u0633 \u0633\u06cc\u060c \u062f\u0627\u060c \u0688\u06cc\u060c \u0641\u0631\u06cc\u0679\u060c \u0627\u06cc\u060c \u0644\u0627\u0624\u060c \u0633\u06cc.\u060c \u0628\u0631\u0627\u0624\u0646\u060c \u0633\u06cc\u060c \u067e\u0627\u06a9\u060c \u0688\u06cc \u0627\u06cc\u0646\u060c \u0648\u0627\u0646\u06af\u060c \u0648\u0627\u0626\u06cc\u060c \u0645\u0686\u06cc\u0631\u060c \u0627\u06d2\u060c \u0648\u0631\u0645\u0646\u060c \u0627\u06cc\u0686 \u062c\u06d2\u060c \u0633\u0646\u062a\u0627\u0646\u0627\u060c \u0627\u06cc\u0644 \u0627\u06cc\u0641\u060c Ladiges, WC, Rabinovich, PS, & Kennedy, BK (2012)\u06d4 \u0644\u0627\u0645\u06cc\u0646 \u0627\u06d2 \u06a9\u0627 \u06a9\u0627\u0631\u0688\u06cc\u0648 \u0645\u0627\u06cc\u0648\u0633\u0627\u0626\u0679 \u0645\u062e\u0635\u0648\u0635 \u0627\u0638\u06c1\u0627\u0631 Lmna-\/- \u0686\u0648\u06c1\u0648\u06ba \u0645\u06cc\u06ba \u06a9\u0627\u0631\u0688\u06cc\u06a9 \u0641\u0646\u06a9\u0634\u0646 \u06a9\u0648 \u0628\u06c1\u062a\u0631 \u0628\u0646\u0627\u062a\u0627 \u06c1\u06d2\u06d4 \u067e\u0644\u0633 \u0648\u0646<\/em>, 7<\/em>(8)\u060c 1-9\u06d4 https:\/\/doi.org\/10.1371\/journal.pone.0042918<\/a><\/p>\n

\u0633\u0644\u06cc\u0648\u0627\u0646\u060c \u0679\u06cc (1999)\u06d4 A-type lamin expression \u06a9\u0627 \u0646\u0642\u0635\u0627\u0646 \u062c\u0648\u06c1\u0631\u06cc \u0644\u0641\u0627\u0641\u06d2 \u06a9\u06cc \u0633\u0627\u0644\u0645\u06cc\u062a \u0633\u06d2 \u0633\u0645\u062c\u06be\u0648\u062a\u06c1 \u06a9\u0631\u062a\u0627 \u06c1\u06d2 \u062c\u0633 \u06a9\u06d2 \u0646\u062a\u06cc\u062c\u06d2 \u0645\u06cc\u06ba \u0639\u0636\u0644\u0627\u062a\u06cc \u0688\u0633\u0679\u0631\u0648\u0641\u06cc \u06c1\u0648\u062a\u06cc \u06c1\u06d2\u06d4 \u062c\u0631\u0646\u0644 \u0622\u0641 \u0633\u06cc\u0644 \u0628\u06cc\u0627\u0644\u0648\u062c\u06cc<\/em>, 147<\/em>(5)\u060c 913-920\u06d4 https:\/\/doi.org\/10.1083\/jcb.147.5.913<\/a><\/p>\n

[\/et_pb_toggle][et_pb_toggle title=” To Dr. Giovanna Lattanzi: 2 Questions and Answers for Dr. Lattanzi listed below.” open_toggle_background_color=”#f7f7f7″ closed_toggle_text_color=”#ffffff” closed_toggle_background_color=”#00b2e2″ icon_color=”#ffc15e” open_icon_color=”#ffc15e” admin_label=”Lattanzi Q&A 2″ _builder_version=”4.16″ _module_preset=”default” title_text_color=”#00b2e2″ title_font=”||||||||” background_color=”#ffffff” custom_margin=”||25px” custom_padding=”|50px||50px||true” border_width_all=”0px” global_colors_info=”{}”]<\/p>\n

\"\"\u0633\u0648\u0627\u0644:<\/span> <\/strong>\u0679\u0627\u0645 \u0645\u06cc\u0633\u0679\u06cc\u0644\u06cc \u0633\u06d2: \u062c\u0627\u0646\u0648\u0631\u0648\u06ba \u0645\u06cc\u06ba \u0644\u0648\u0646\u0627\u0641\u0631\u0646\u06cc\u0628 + \u0679\u0648\u0632\u06cc\u0644\u06cc\u0632\u0648\u0645\u0627\u0628 \u06a9\u0627 \u0639\u0644\u0627\u062c \u06a9\u0628 \u062a\u06a9 \u062a\u06be\u0627\u061f
\u062c\u0648\u0627\u0628:<\/span> <\/strong>\u06c1\u0645 \u0646\u06d2 \u0645\u062a\u0641\u0627\u0648\u062a \u062c\u0627\u0646\u0648\u0631\u0648\u06ba \u067e\u0631 \u0627\u06cc\u06a9 \u0627\u0628\u062a\u062f\u0627\u0626\u06cc \u062a\u062c\u0631\u0628\u06c1 \u06a9\u06cc\u0627 \u062c\u0648 \u06c1\u0641\u062a\u06c1 22 \u0633\u06d2 30 \u06c1\u0641\u062a\u06c1 \u062a\u06a9 \u0634\u0631\u0648\u0639 \u06c1\u0648\u062a\u0627 \u06c1\u06d2\u06d4 \u06c1\u0645 \u0648\u0632\u0646 \u0645\u06cc\u06ba \u0627\u0636\u0627\u0641\u06d2 \u067e\u0631 \u0627\u062b\u0631\u0627\u062a \u06a9\u0627 \u062c\u0627\u0626\u0632\u06c1 \u0644\u06cc\u0646\u06d2 \u06a9\u06d2 \u0644\u06cc\u06d2 \u0627\u0633 \u0679\u0627\u0626\u0645 \u0641\u0631\u06cc\u0645 \u067e\u0631 \u062a\u0648\u062c\u06c1 \u0645\u0631\u06a9\u0648\u0632 \u06a9\u0631\u0646\u0627 \u0686\u0627\u06c1\u062a\u06d2 \u06c1\u06cc\u06ba \u062c\u0648 \u067e\u06c1\u0644\u06d2 \u0679\u0648\u06a9\u06cc\u0644\u06cc\u0632\u0648\u0645\u0627\u0628 \u06a9\u06d2 \u0633\u0627\u062a\u06be \u062f\u06cc\u06a9\u06be\u0627 \u06af\u06cc\u0627 \u062a\u06be\u0627\u06d4<\/p>\n

\u0633\u0648\u0627\u0644: <\/strong><\/span>Sgonzalo \u0633\u06d2: \u062e\u0648\u0628\u0635\u0648\u0631\u062a \u06a9\u06c1\u0627\u0646\u06cc \u062c\u06cc\u0648\u0627\u0646\u0627 \u0627\u0648\u0631 \u0633\u06cc\u0645\u06cc!!! \u06a9\u06cc\u0627 \u0622\u067e \u0646\u06d2 tocilizumab \u0639\u0644\u0627\u062c \u06a9\u06d2 \u06a9\u0648\u0626\u06cc \u0645\u0636\u0631 \u0627\u062b\u0631\u0627\u062a \u062f\u06cc\u06a9\u06be\u06d2 \u06c1\u06cc\u06ba\u061f \u06cc\u0627 \u06a9\u0648\u0626\u06cc \u0641\u06cc\u0646\u0648\u0679\u0627\u0626\u067e\u0633 \u062c\u0648 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u0686\u0648\u06c1\u0648\u06ba \u0645\u06cc\u06ba \u0628\u06c1\u062a\u0631 \u0646\u06c1\u06cc\u06ba \u06c1\u0648\u0626\u06cc \u062a\u06be\u06cc\u06ba\u061f \u0688\u0627\u06a9\u0679\u0631 Giovanna Lattanzi \u0633\u06d2: \u0633\u0648\u0627\u0644: tom misteli \u0633\u06d2: lonafarnib + tozilizumab \u06a9\u0627 \u062c\u0627\u0646\u0648\u0631\u0648\u06ba \u0645\u06cc\u06ba \u0639\u0644\u0627\u062c \u06a9\u0628 \u062a\u06a9 \u06c1\u0648\u062a\u0627 \u062a\u06be\u0627\u061f
\u062c\u0648\u0627\u0628: <\/strong><\/span>\u0634\u06a9\u0631\u06cc\u06c1 \u0633\u0648\u0632\u0627\u0646\u0627\u06d4 \u0646\u06c1\u06cc\u06ba\u060c \u06c1\u0645 \u0646\u06d2 tocilizumab \u06a9\u0627 \u06a9\u0648\u0626\u06cc \u0645\u0636\u0631 \u0627\u062b\u0631 \u0646\u06c1\u06cc\u06ba \u062f\u06cc\u06a9\u06be\u0627\u06d4 \u062c\u0627\u0646\u0686\u06d2 \u06af\u0626\u06d2 \u0641\u06cc\u0646\u0648\u0679\u0627\u0626\u067e\u0633 \u0645\u06cc\u06ba (\u06a9\u0627\u0626\u0641\u0648\u0633\u060c \u0627\u06cc\u0688\u06cc\u067e\u0648\u0632 \u0679\u0634\u0648 \u0688\u0633\u0679\u0631\u0648\u0641\u06cc\u060c \u0628\u0627\u0644\u0648\u06ba \u0627\u0648\u0631 \u062c\u0644\u062f \u06a9\u06d2 \u0646\u0642\u0627\u0626\u0635\u060c \u0644\u0648\u06a9\u0648\u0645\u0648\u0679\u0631 \u0627\u06cc\u06a9\u0679\u06cc\u0648\u06cc\u0679\u06cc\u060c \u0634\u06c1 \u0631\u06af \u06a9\u06d2 \u06af\u06be\u0627\u0648\u0648\u06ba \u0627\u0648\u0631 \u0645\u0627\u06cc\u0648\u06a9\u0627\u0631\u0688\u06cc\u0645 \u06c1\u0627\u0626\u067e\u0631 \u062a\u06be\u0631\u0648\u0641\u06cc) \u0645\u06cc\u06ba \u062a\u0627\u062e\u06cc\u0631\/\u0628\u06c1\u062a\u0631\u06cc \u06c1\u0648\u0626\u06cc \u062a\u06be\u06cc\u06d4<\/p>\n

\u062a\u0628\u0635\u0631\u06c1: <\/strong><\/span>MARIE GERHARD-HERMAN \u0633\u06d2: \u0627\u0645\u0631\u06cc\u06a9\u06c1 \u0645\u06cc\u06ba \u0631\u06cc\u0645\u06cc\u0679\u0648\u0644\u0648\u062c\u0633\u0679 \u06a9\u06cc \u0628\u06cc\u0645\u0627\u0631\u06cc \u0627\u0648\u0631 \u0648\u06cc\u0633\u06a9\u0648\u0644\u0627\u0626\u0679\u0633 \u06a9\u06d2 \u0644\u06cc\u06d2 \u0628\u06be\u06cc \u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u06c1\u0648\u062a\u0627 \u06c1\u06d2
\u062c\u0648\u0627\u0628:<\/span> <\/strong>\u0648\u06cc\u0633\u06a9\u0648\u0644\u0627\u0626\u0679\u0633 \u06a9\u06d2 \u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u06a9\u06d2 \u0628\u0627\u0631\u06d2 \u0645\u06cc\u06ba \u0627\u0633 \u062f\u0644\u0686\u0633\u067e \u0645\u0639\u0644\u0648\u0645\u0627\u062a \u06a9\u06d2 \u0644\u0626\u06d2 \u0645\u06cc\u0631\u06cc \u06a9\u0627 \u0634\u06a9\u0631\u06cc\u06c1\u06d4<\/p>\n

\u062a\u0628\u0635\u0631\u06c1:<\/span> <\/strong>\u067e\u06cc \u0633\u06cc \u0633\u0679\u06cc\u0641\u0627\u0646\u0648 \u06a9\u06cc \u0637\u0631\u0641 \u0633\u06d2: \u062c\u0627\u067e\u0627\u0646 \u0645\u06cc\u06ba \u06a9\u06cc\u0633\u0644 \u0645\u06cc\u0646 \u0628\u06cc\u0645\u0627\u0631\u06cc \u06a9\u06d2 \u0639\u0644\u0627\u062c \u06a9\u06d2 \u0644\u06cc\u06d2 \u062a\u0648\u0633\u06cc\u0644\u06cc\u0632\u0648\u0645\u0627\u0628 \u06a9\u06cc \u0628\u06be\u06cc \u0645\u0646\u0638\u0648\u0631\u06cc \u062f\u06cc \u06af\u0626\u06cc \u06c1\u06d2 \u062c\u0633 \u06a9\u06d2 \u0628\u063a\u06cc\u0631 \u0645\u062f\u0627\u0641\u0639\u062a\u06cc \u0627\u062b\u0631\u0627\u062a \u06c1\u06cc\u06ba
\u062c\u0648\u0627\u0628: <\/strong><\/span>\u0627\u0646 \u0645\u0639\u0644\u0648\u0645\u0627\u062a \u06a9\u06d2 \u0644\u06cc\u06d2 \u0633\u0679\u06cc\u0641\u0627\u0646\u0648 \u06a9\u0627 \u0634\u06a9\u0631\u06cc\u06c1\u06d4<\/p>\n

[\/et_pb_toggle][et_pb_toggle title=”To Dr. Minju Kim and Somi Kang who presented on behalf of Dr. Bum-Joon Park: 8 Questions and Answers for Dr. Minju Kim and Somi Kanglisted below.” open_toggle_background_color=”#f7f7f7″ closed_toggle_text_color=”#ffffff” closed_toggle_background_color=”#00b2e2″ icon_color=”#ffc15e” open_icon_color=”#ffc15e” admin_label=”Kim and Kang Q&A 6 questions” _builder_version=”4.16″ _module_preset=”default” title_text_color=”#00b2e2″ title_font=”||||||||” background_color=”#ffffff” custom_margin=”||25px” custom_padding=”|50px||50px||true” border_width_all=”0px” global_colors_info=”{}”]<\/p>\n

\"\"\"\" <\/strong><\/p>\n

\u0633\u0648\u0627\u0644:<\/span> <\/strong>\u0688\u06cc\u0644\u0641\u0627\u0626\u0646 \u0644\u0627\u0631\u0631\u06cc\u0648 \u0633\u06d2: \u06a9\u06cc\u0627 \u0622\u067e HGPS \u0633\u06cc\u0644\u0632\/HGPS \u0645\u0627\u0624\u0633 \u0645\u0627\u0688\u0644\u0632 \u0645\u06cc\u06ba \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0646\u0646 \u0679\u0631\u06cc\u0679\u0645\u0646\u0679 \u0633\u06d2 \u0688\u06cc \u0627\u06cc\u0646 \u0627\u06d2 \u06a9\u0648 \u067e\u06c1\u0646\u0686\u0646\u06d2 \u0648\u0627\u0644\u06d2 \u0646\u0642\u0635\u0627\u0646 \u0645\u06cc\u06ba \u06a9\u0645\u06cc \u062f\u06cc\u06a9\u06be\u062a\u06d2 \u06c1\u06cc\u06ba\u061f
\u062c\u0648\u0627\u0628: <\/strong><\/span>\u06c1\u0645 \u0646\u06d2 \u0645\u0634\u0627\u06c1\u062f\u06c1 \u06a9\u06cc\u0627 \u06a9\u06c1 \u0688\u06cc \u0627\u06cc\u0646 \u0627\u06d2 \u06a9\u06cc \u0645\u0631\u0645\u062a \u0633\u06d2 \u0645\u062a\u0639\u0644\u0642 \u062c\u06cc\u0646 (BRCA1\u060c Rad51\u060c \u0648\u063a\u06cc\u0631\u06c1) \u06a9\u0648 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0646\u0646 \u06a9\u06d2 \u0633\u0627\u062a\u06be \u0639\u0644\u0627\u062c \u06a9\u06d2 \u0628\u0639\u062f \u062a\u0628\u062f\u06cc\u0644 \u06a9\u06cc\u0627 \u06af\u06cc\u0627 \u062a\u06be\u0627\u06d4<\/p>\n

\u0633\u0648\u0627\u0644:<\/strong> <\/span>\u0688\u06cc\u0644\u0641\u0627\u0626\u0646 \u0644\u06cc\u0631\u06cc\u0648 \u0633\u06d2: \u0648\u0631\u0646\u0631 \u0645\u06cc\u06ba \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0646\u0646 \u06a9\u06cc\u0633\u06d2 \u06a9\u0627\u0645 \u06a9\u0631\u062a\u0627 \u06c1\u06d2\u06d4
\u0633\u0646\u0688\u0631\u0648\u0645 \u062c\u0648 - \u062c\u06c1\u0627\u06ba \u062a\u06a9 \u0645\u06cc\u06ba \u062c\u0627\u0646\u062a\u0627 \u06c1\u0648\u06ba - \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0646 \u06a9\u0627 \u0627\u0638\u06c1\u0627\u0631 \u0646\u06c1\u06cc\u06ba \u06a9\u0631\u062a\u0627 \u06c1\u06d2\u061f \u06a9\u06cc\u0627 \u0645\u0627\u0644\u06cc\u06a9\u06cc\u0648\u0644 \u06a9\u0627 \u06a9\u0648\u0626\u06cc \u0627\u0648\u0631 \u06c1\u062f\u0641 \u06c1\u06d2\u061f
\u062c\u0648\u0627\u0628: <\/strong><\/span>\u0688\u0628\u0644\u06cc\u0648 \u0627\u06cc\u0633 \u06a9\u06d2 \u062e\u0644\u06cc\u06d2 \u0628\u06be\u06cc \u0639\u0627\u0645 \u0639\u0645\u0631 \u06a9\u06cc \u0637\u0631\u062d \u062a\u06be\u0648\u0691\u06cc \u0645\u0642\u062f\u0627\u0631 \u0645\u06cc\u06ba \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0646 \u067e\u06cc\u062f\u0627 \u06a9\u0631 \u0633\u06a9\u062a\u06d2 \u06c1\u06cc\u06ba\u06d4
\u062e\u0644\u06cc\u0627\u062a \u06c1\u0645 \u0646\u06d2 \u0627\u06cc\u0645 \u0622\u0631 \u0627\u06cc\u0646 \u0627\u06d2 \u06a9\u06cc \u0633\u0637\u062d \u067e\u0631 \u0688\u0628\u0644\u06cc\u0648 \u0627\u06cc\u0633 \u062e\u0644\u06cc\u0648\u06ba \u0645\u06cc\u06ba \u067e\u0631\u0648\u062c\u06cc\u0631\u0646 \u0627\u0638\u06c1\u0627\u0631 \u06a9\u0627 \u0645\u0634\u0627\u06c1\u062f\u06c1 \u06a9\u06cc\u0627\u06d4
\u06c1\u0645\u0627\u0631\u0627 \u062e\u06cc\u0627\u0644 \u06c1\u06d2 \u06a9\u06c1 \u0688\u0628\u0644\u06cc\u0648 \u0622\u0631 \u0627\u06cc\u0646 \u067e\u0631\u0648\u0679\u06cc\u0646 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0646 \u06a9\u0648 \u0631\u0648\u06a9\u0646\u06d2 \u06a9\u06d2 \u0644\u06cc\u06d2 \u06a9\u0627\u0645 \u06a9\u0631 \u0633\u06a9\u062a\u0627 \u06c1\u06d2\u06d4 \u062a\u0627\u06c1\u0645\u060c \u0645\u06cc\u06ba
WS \u0645\u0631\u06cc\u0636\u0648\u06ba \u06a9\u06d2 \u0645\u0639\u0627\u0645\u0644\u06d2 \u0645\u06cc\u06ba\u060c \u0686\u0648\u0646\u06a9\u06c1 \u06a9\u0648\u0626\u06cc WRN \u067e\u0631\u0648\u0679\u06cc\u0646 \u0646\u06c1\u06cc\u06ba \u06c1\u06d2\u060c progerin \u0627\u0638\u06c1\u0627\u0631 \u06c1\u06d2\u06d4
20 \u0627\u0648\u0631 30 \u06a9\u06cc \u062f\u06c1\u0627\u0626\u06cc \u0645\u06cc\u06ba \u06c1\u0648\u0646\u06d2 \u06a9\u06d2 \u0628\u0627\u0631\u06d2 \u0645\u06cc\u06ba \u0633\u0648\u0686\u0627 \u062c\u0627\u062a\u0627 \u06c1\u06d2\u060c \u062c\u062a\u0646\u0627 \u06cc\u06c1 \u0639\u0627\u0645 \u0637\u0648\u0631 \u067e\u0631 \u0639\u0645\u0631 \u0631\u0633\u06cc\u062f\u06c1 \u0627\u0641\u0631\u0627\u062f \u0645\u06cc\u06ba \u062f\u06cc\u06a9\u06be\u0627 \u062c\u0627\u062a\u0627 \u06c1\u06d2\u06d4
\u0644\u0648\u06af<\/p>\n

\u0633\u0648\u0627\u0644: <\/strong><\/span>\u0628\u0627\u0628 \u0628\u0634\u067e \u0633\u06d2: \u06a9\u06cc\u0627 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0646\u0646 \u0628\u0627\u0626\u0646\u0688\u0646\u06af \u0633\u0627\u0626\u0679 \u06a9\u0648 \u0628\u0627\u0626\u06cc\u0648 \u06a9\u06cc\u0645\u06cc\u06a9\u0644 \u0637\u0648\u0631 \u067e\u0631 \u0628\u06cc\u0627\u0646 \u06a9\u06cc\u0627 \u06af\u06cc\u0627 \u06c1\u06d2 \u06cc\u0627\u061f
\u0633\u0627\u062e\u062a\u06cc \u0637\u0648\u0631 \u067e\u0631\u061f \u06a9\u06cc\u0627 \u0627\u0636\u0627\u0641\u06cc \u0645\u0631\u06a9\u0628\u0627\u062a \u062a\u0644\u0627\u0634 \u06a9\u0631\u0646\u06d2 \u06a9\u06d2 \u0644\u06cc\u06d2 \u06a9\u0648\u0626\u06cc \u0628\u0627\u0626\u06cc\u0648 \u06a9\u06cc\u0645\u06cc\u06a9\u0644 \u067e\u0631\u06a9\u06be \u06c1\u06d2\u061f
\u0627\u0633 \u0645\u06cc\u06a9\u0627\u0646\u0632\u0645 \u06a9\u06d2 \u0633\u0627\u062a\u06be\u061f
\u062c\u0648\u0627\u0628: <\/strong><\/span>\u06c1\u0645 \u0646\u06d2 \u0628\u0627\u06cc\u0648\u0679\u06cc\u0646-\u0627\u06cc\u0648\u0688\u0646 \u0645\u0627\u0644\u0627 \u067e\u0644-\u0688\u0627\u0648\u0646 \u067e\u0631\u06a9\u06be \u06a9\u0627 \u0645\u0638\u0627\u06c1\u0631\u06c1 \u06a9\u06cc\u0627 \u0627\u0648\u0631 \u0645\u0634\u0627\u06c1\u062f\u06c1 \u06a9\u06cc\u0627\u06d4
\u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0646 \u06a9\u06d2 \u0633\u0627\u062a\u06be \u067e\u06cc\u0631\u0648\u062c\u06cc\u0631\u06cc\u0646\u0646 \u06a9\u0627 \u0645\u062e\u0635\u0648\u0635 \u062a\u0639\u0627\u0645\u0644 \u0644\u06cc\u06a9\u0646 \u0644\u0627\u0645\u06cc\u0646 \u0627\u06d2\u060c \u0644\u0627\u0645\u06cc\u0646 \u06a9\u06d2 \u0633\u0627\u062a\u06be \u0646\u06c1\u06cc\u06ba\u06d4
B\u060c p53\u060c \u06cc\u0627 \u0627\u06cc\u0645\u0631\u06cc\u0646\u06d4
\u06c1\u0645 \u0646\u06d2 \u0627\u0636\u0627\u0641\u06cc \u0645\u0631\u06a9\u0628\u0627\u062a \u062a\u0644\u0627\u0634 \u06a9\u0631\u0646\u06d2 \u06a9\u06d2 \u0644\u0626\u06d2 \u0627\u06cc\u0644\u06cc\u0633\u0627 \u067e\u0631\u06a9\u06be \u0628\u06be\u06cc \u0627\u0646\u062c\u0627\u0645 \u062f\u06cc\u0627 \u062c\u0648 \u06c1\u0648\u0633\u06a9\u062a\u0627 \u06c1\u06d2\u06d4
\u067e\u0648\u0679\u06cc\u0679\u06cc\u0648 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0646\/\u0644\u0627\u0645\u06cc\u0646 \u0627\u06d2 \u0628\u0627\u0626\u0646\u0688\u0646\u06af \u0627\u0646\u062d\u06cc\u0628\u06cc\u0679\u0631\u0632 \u0628\u0646\u06cc\u06ba\u06d4 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0646 \u0631\u06cc\u06a9\u0648\u0645\u0628\u06cc\u0646\u0646\u0679 \u067e\u0631\u0648\u0679\u06cc\u0646 \u06a9\u0648 \u06a9\u06cc\u0645\u06cc\u06a9\u0644 \u0644\u0627\u0626\u0628\u0631\u06cc\u0631\u06cc \u0627\u0648\u0631 \u0644\u0627\u0645\u06cc\u0646 \u0627\u06d2 \u06a9\u06d2 \u0633\u0627\u062a\u06be \u062a\u0631\u062a\u06cc\u0628 \u0648\u0627\u0631 \u0627\u0646\u06a9\u06cc\u0648\u0628\u06cc\u0679 \u06a9\u06cc\u0627 \u06af\u06cc\u0627 \u062a\u06be\u0627\u06d4
\u062a\u0627\u06c1\u0645\u060c \u06a9\u06cc\u0645\u06cc\u06a9\u0644 \u0645\u06cc\u06ba \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0646\u0646 \u0633\u0628 \u0633\u06d2 \u0632\u06cc\u0627\u062f\u06c1 \u0645\u0648\u062b\u0631 \u06a9\u06cc\u0645\u06cc\u06a9\u0644 \u062a\u06be\u0627\u06d4
\u0644\u0627\u0626\u0628\u0631\u06cc\u0631\u06cc\"\"<\/p>\n

\"\"<\/p>\n

\u0633\u0648\u0627\u0644: <\/strong><\/span>\u062c\u0627\u0646 \u06a9\u0648\u06a9 \u06a9\u06cc \u0637\u0631\u0641 \u0633\u06d2: \u0639\u0638\u06cc\u0645 \u067e\u06cc\u0634 \u0631\u0641\u062a \u0688\u0627\u06a9\u0679\u0631 \u06a9\u0645\u06d4 \u06a9\u06cc\u0627 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0646\u0646 \u06a9\u0648 \u06a9\u0645 \u06a9\u0631\u062a\u0627 \u06c1\u06d2\u061f
SASP \u0633\u0627\u0626\u0679\u0648\u06a9\u0627\u0626\u0646\u0632 \u06a9\u0627 \u0633\u0631\u0627\u0648\u061f
\u062c\u0648\u0627\u0628: <\/strong><\/span>\u06c1\u0645 \u0646\u06d2 \u0645\u0634\u0627\u06c1\u062f\u06c1 \u06a9\u06cc\u0627 \u06a9\u06c1 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0646\u0646 IL6 \u0627\u0648\u0631 IL8 \u06a9\u06d2 \u0627\u0638\u06c1\u0627\u0631 \u06a9\u0648 \u06a9\u0645 \u06a9\u0631 \u0633\u06a9\u062a\u0627 \u06c1\u06d2\u06d4
HGPS \u062e\u0644\u06cc\u0627\u062a\u06d4<\/p>\n

\u0633\u0648\u0627\u0644: <\/strong><\/span>\u0633\u0648\u0633\u0646 \u0645\u0627\u0626\u06cc\u06a9\u0644\u0633 \u0633\u06d2: \u06a9\u06cc\u0627 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0646\u0646 \u0645\u062d\u0642\u0642\u06cc\u0646 \u06a9\u06d2 \u0644\u06cc\u06d2 \u062f\u0633\u062a\u06cc\u0627\u0628 \u06c1\u06d2\u061f
\u062c\u0648\u0627\u0628: <\/strong><\/span>\u06cc\u0642\u06cc\u0646\u0627\u060c \u0627\u06af\u0631 \u0622\u067e \u062f\u0631\u062e\u0648\u0627\u0633\u062a \u06a9\u0631\u062a\u06d2 \u06c1\u06cc\u06ba \u062a\u0648 \u06cc\u06c1 \u062f\u0633\u062a\u06cc\u0627\u0628 \u06c1\u06d2\u06d4<\/p>\n

\u0633\u0648\u0627\u0644: <\/strong><\/span>\u062a\u06be\u0627\u0645\u0633 \u0688\u0628\u0644\u06cc\u0648 \u06af\u0644\u0648\u0648\u0631 \u0633\u06d2: \u0645\u06cc\u06ba \u0646\u06d2 \u0627\u0633\u06d2 \u06cc\u0627\u062f \u06a9\u06cc\u0627 \u06c1\u0648 \u06af\u0627 \u0644\u06cc\u06a9\u0646 \u0622\u067e \u06a9\u06d2 \u062e\u06cc\u0627\u0644 \u0645\u06cc\u06ba \u06cc\u06c1 \u06a9\u06cc\u0627 \u06c1\u06d2\u061f
Werner \u0633\u0646\u0688\u0631\u0648\u0645 \u0645\u06cc\u06ba \u0641\u0627\u0626\u062f\u06c1 \u0645\u0646\u062f \u0627\u062b\u0631\u0627\u062a \u06a9\u06d2 \u0644\u0626\u06d2 \u0630\u0645\u06c1 \u062f\u0627\u0631 \u0637\u0631\u06cc\u0642\u06c1 \u06a9\u0627\u0631\u061f
\u062c\u0648\u0627\u0628: <\/strong><\/span>WS \u0645\u0631\u06cc\u0636\u0648\u06ba \u0633\u06d2 \u062d\u0627\u0635\u0644 \u06a9\u0631\u062f\u06c1 \u062e\u0644\u06cc\u0627\u062a \u0628\u06be\u06cc \u062a\u06be\u0648\u0691\u06cc \u0645\u0642\u062f\u0627\u0631 \u0645\u06cc\u06ba \u067e\u0631\u0648\u062c\u0631\u06cc\u0646 \u062a\u06cc\u0627\u0631 \u06a9\u0631\u062a\u06d2 \u06c1\u06cc\u06ba\u060c \u062c\u06cc\u0633\u0627 \u06a9\u06c1
\u0632\u06cc\u0627\u062f\u06c1 \u0639\u0645\u0631 \u06a9\u06d2 \u0644\u0648\u06af\u0648\u06ba \u0633\u06d2 \u062d\u0627\u0635\u0644 \u06a9\u0631\u062f\u06c1 \u0639\u0627\u0645 \u062e\u0644\u06cc\u0627\u062a \u06a9\u06d2 \u0637\u0648\u0631 \u067e\u0631. \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0646\u0646 \u0628\u06be\u06cc \u06c1\u0648 \u0633\u06a9\u062a\u0627 \u06c1\u06d2\u06d4
\u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0646 \u0627\u0638\u06c1\u0627\u0631 \u06a9\u0648 \u06a9\u0645 \u06a9\u0631\u06a9\u06d2 \u0688\u0628\u0644\u06cc\u0648 \u0627\u06cc\u0633 \u062e\u0644\u06cc\u0648\u06ba \u0645\u06cc\u06ba \u0645\u0648\u062b\u0631\u06d4<\/p>\n

[\/et_pb_toggle][et_pb_toggle title=”To Dr. Martin Berg\u00f6: Question: From Mario D. Cordero: Have you studied the effect about inflammation?” open_toggle_background_color=”#f7f7f7″ closed_toggle_text_color=”#ffffff” closed_toggle_background_color=”#00b2e2″ icon_color=”#ffc15e” open_icon_color=”#ffc15e” admin_label=”Dr. Martin Berg\u00f6” _builder_version=”4.16″ _module_preset=”default” title_text_color=”#00b2e2″ title_font=”||||||||” background_color=”#ffffff” custom_margin=”||25px” custom_padding=”|50px||50px||true” border_width_all=”0px” global_colors_info=”{}”]<\/p>\n

\"\"\u062c\u0648\u0627\u0628: <\/strong>\u0633\u0648\u0627\u0644 \u06a9\u06d2 \u0644\u06cc\u06d2 \u0634\u06a9\u0631\u06cc\u06c1: \u0646\u06c1\u06cc\u06ba\u060c \u0641\u06cc \u0646\u0641\u0633\u06c1 \u0633\u0648\u0632\u0634 \u0646\u06c1\u06cc\u06ba\u06d4 \u062c\u0632\u0648\u06cc \u0637\u0648\u0631 \u067e\u0631 \u0633\u0648\u0632\u0634 \u0633\u06d2 \u0645\u062a\u0639\u0644\u0642\u060c \u06c1\u0645 \u0646\u06d2 \u0627\u0633 \u067e\u0631\u0648\u062c\u06cc\u06a9\u0679 \u0645\u06cc\u06ba \u0645\u06cc\u06a9\u0631\u0648\u0641\u06cc\u062c\u0632 \u06a9\u0627 \u0645\u0637\u0627\u0644\u0639\u06c1 \u06a9\u06cc\u0627 \u06c1\u06d2 \u0627\u0648\u0631 \u067e\u062a\u06c1 \u0686\u0644\u0627 \u06c1\u06d2 \u06a9\u06c1 \u0646\u0627\u06a9 \u0622\u0624\u0679\u00a0\u0622\u0626\u06cc \u0633\u06cc \u0627\u06cc\u0645 \u0679\u06cc<\/i>\u00a0\u0645\u06cc\u06a9\u0631\u0648\u0641\u06cc\u062c \u06a9\u0648\u0644\u06cc\u0633\u0679\u0631\u0648\u0644 \u06a9\u06d2 \u0628\u06c1\u0627\u0624 \u06a9\u0648 \u0628\u0691\u06be\u0627\u062a\u0627 \u06c1\u06d2\u060c \u062f\u0648\u0646\u0648\u06ba \u0628\u06cc\u0633\u0644 \u0627\u0648\u0631 ApoAI- \u0627\u0648\u0631 HDL- \u0645\u062d\u0631\u06a9\u06d4 \u0686\u0648\u0646\u06a9\u06c1 \u06cc\u06c1 \u0627\u062b\u0631 \u06a9\u0628\u06be\u06cc \u06a9\u0628\u06be\u06cc Vivo \u0645\u06cc\u06ba \u0631\u06cc\u0648\u0631\u0633 \u06a9\u0648\u0644\u06cc\u0633\u0679\u0631\u0648\u0644 \u06a9\u06cc \u0646\u0642\u0644 \u0648 \u062d\u0645\u0644 \u0633\u06d2 \u0645\u0646\u0633\u0644\u06a9 \u06c1\u0648\u062a\u0627 \u06c1\u06d2\u060c \u06c1\u0645 \u0627\u0633 \u0628\u0627\u062a \u06a9\u0627 \u062a\u0639\u06cc\u0646 \u06a9\u0631\u0646\u0627 \u0686\u0627\u06c1\u06cc\u06ba \u06af\u06d2 \u06a9\u06c1 \u0622\u06cc\u0627\u00a0\u0622\u0626\u06cc \u0633\u06cc \u0627\u06cc\u0645 \u0679\u06cc<\/i>\u00a0\u0631\u0648\u06a9\u0646\u0627 atherosclerosis \u06a9\u06cc \u062a\u0631\u0642\u06cc \u06a9\u0648 \u06a9\u0645 \u06a9\u0631\u06d2 \u06af\u0627\u06d4<\/p>\n

[\/et_pb_toggle][et_pb_toggle title=”To Dr. David Liu: Question: 3 Questions and Answers for Dr. Lui listed below.” open_toggle_background_color=”#f7f7f7″ closed_toggle_text_color=”#ffffff” closed_toggle_background_color=”#00b2e2″ icon_color=”#ffc15e” open_icon_color=”#ffc15e” admin_label=”Dr. David Liu Q&A 3″ _builder_version=”4.16″ _module_preset=”default” title_text_color=”#00b2e2″ title_font=”||||||||” background_color=”#ffffff” custom_margin=”||25px” custom_padding=”|50px||50px||true” border_width_all=”0px” global_colors_info=”{}”]<\/p>\n

\"\"<\/p>\n

\u0633\u0648\u0627\u0644: <\/strong><\/span>\u0648\u06cc\u0646\u0688\u0631\u06cc\u0633 \u0633\u06d2: \u06a9\u06cc\u0627 \u0622\u067e \u0646\u06d2 \u0645\u062e\u062a\u0644\u0641 \u0639\u0645\u0631\u0648\u06ba \u06a9\u06d2 \u0627\u0646\u0633\u0627\u0646\u06cc \u0627\u06cc\u0686 \u062c\u06cc \u067e\u06cc \u0627\u06cc\u0633 \u0641\u0627\u0626\u0628\u0631\u0648 \u0628\u0644\u0627\u0633\u0679\u0633 \u0645\u06cc\u06ba \u0688\u06cc \u0627\u06cc\u0646 \u0627\u06d2 \u062f\u0631\u0633\u062a \u06a9\u0631\u0646\u06d2 \u06a9\u06cc \u06a9\u0648\u0634\u0634 \u06a9\u06cc \u06c1\u06d2 (\u0627\u0646 \u0648\u0679\u0631\u0648) \u0627\u0648\u0631 \u0627\u0646 \u06a9\u06d2 \u0641\u06cc\u0646\u0648\u0679\u0627\u0626\u067e \u06a9\u0648 \u0646\u0627\u0631\u0645\u0644\u0627\u0626\u0632 \u06a9\u0631\u0646\u06d2 \u06a9\u0627 \u062a\u062c\u0631\u0628\u06c1 \u06a9\u06cc\u0627 \u06c1\u06d2 \u062a\u0627\u06a9\u06c1 \u06cc\u06c1 \u0645\u0639\u0644\u0648\u0645 \u06a9\u06cc\u0627 \u062c\u0627 \u0633\u06a9\u06d2 \u06a9\u06c1 \u06a9\u06cc\u0627 \u06cc\u06c1 \u062e\u0644\u06cc\u0627\u062a \u06a9\u06cc \u0639\u0645\u0631 \u06a9\u06d2 \u0633\u0627\u062a\u06be \u06a9\u0645 \u06c1\u0648\u062a\u0627 \u06c1\u06d2\u061f
\u062c\u0648\u0627\u0628:<\/span> <\/strong>\u0646\u06c1\u06cc\u06ba\u060c \u06c1\u0645 \u0646\u06d2 \u06a9\u0626\u06cc \u0645\u062e\u062a\u0644\u0641 \u0639\u0645\u0631\u0648\u06ba \u06a9\u06d2 \u0645\u0631\u06cc\u0636\u0648\u06ba \u0633\u06d2 \u0641\u0628\u0631\u0648 \u0628\u0644\u0648\u0633\u0679\u0633 \u0645\u06cc\u06ba \u0627\u0635\u0644\u0627\u062d \u06a9\u06cc \u06a9\u0648\u0634\u0634 \u0646\u06c1\u06cc\u06ba \u06a9\u06cc \u06c1\u06d2 - \u0635\u0631\u0641 \u062f\u0648 \u0645\u062e\u062a\u0644\u0641 \u0645\u0631\u06cc\u0636\u0648\u06ba \u0633\u06d2\u060c \u062c\u0633 \u06a9\u06d2 \u0627\u06cc\u06a9 \u062c\u06cc\u0633\u06d2 \u0646\u062a\u0627\u0626\u062c \u0628\u0631\u0622\u0645\u062f \u06c1\u0648\u0626\u06d2\u06d4<\/p>\n

\u0633\u0648\u0627\u0644:<\/strong> <\/span>\u0688\u06cc\u0644\u0641\u0627\u0626\u0646 \u0644\u06cc\u0631\u06cc\u0648 \u0633\u06d2: \u062d\u06cc\u0631\u062a \u0627\u0646\u06af\u06cc\u0632 \u0627\u062b\u0631\u0627\u062a! \u06a9\u06cc\u0627 \u0622\u067e heterozygous \u0686\u0648\u06c1\u0648\u06ba \u0645\u06cc\u06ba \u0645\u06a9\u0645\u0644 progerin KO \u06a9\u06cc \u062a\u0648\u0642\u0639 \u06a9\u0631\u06cc\u06ba \u06af\u06d2\u061f
\u062c\u0648\u0627\u0628:<\/span> <\/strong>\u0633\u0646\u06af\u0644 \u06a9\u0627\u067e\u06cc \u0645\u0627\u0624\u0633 \u0645\u06cc\u06ba\u060c \u0645\u06cc\u06ba \u0636\u0631\u0648\u0631\u06cc \u0637\u0648\u0631 \u067e\u0631 \u0627\u0633 \u0633\u06d2 \u06a9\u06c1\u06cc\u06ba \u0632\u06cc\u0627\u062f\u06c1 \u0645\u062e\u062a\u0644\u0641 \u0627\u06cc\u0688\u06cc\u0679\u0646\u06af \u0627\u0641\u0627\u062f\u06cc\u062a \u06a9\u06cc \u062a\u0648\u0642\u0639 \u0646\u06c1\u06cc\u06ba \u06a9\u0631\u0648\u06ba \u06af\u0627 \u062c\u0633 \u06a9\u0627 \u06c1\u0645 \u0641\u06cc \u0627\u0644\u062d\u0627\u0644 \u0645\u0634\u0627\u06c1\u062f\u06c1 \u06a9\u0631\u062a\u06d2 \u06c1\u06cc\u06ba\u060c \u06a9\u06cc\u0648\u0646\u06a9\u06c1 \u06c1\u0631 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0646 \u06a9\u06d2 \u0644\u06cc\u06d2 \u067e\u06c1\u0644\u06d2 \u0633\u06d2 \u06c1\u06cc \u0627\u06cc\u0688\u06cc\u0679\u0646\u06af \u0627\u06cc\u062c\u0646\u0679 \u06a9\u06cc \u0632\u06cc\u0627\u062f\u062a\u06cc \u06c1\u0648\u0646\u06cc \u0686\u0627\u06c1\u06cc\u06d2\u06d4<\/p>\n

\u0633\u0648\u0627\u0644: <\/span><\/strong>\u0622\u0646\u062f\u0631\u06d2 \u0645\u0648\u0646\u0679\u06cc\u0631\u0648 \u0688\u0627 \u0631\u0648\u0686\u0627 \u0633\u06d2: \u06a9\u06cc\u0627 \u0622\u067e \u06a9\u0648 \u0644\u06af\u062a\u0627 \u06c1\u06d2 \u06a9\u06c1 \u062e\u0644\u06cc\u0627\u062a \u06a9\u06cc \u06a9\u0645 \u0641\u06cc\u0635\u062f \u06a9\u0648 \u062f\u0648\u0628\u0627\u0631\u06c1 \u067e\u0631\u0648\u06af\u0631\u0627\u0645 \u06a9\u0631\u0646\u06d2 \u0633\u06d2 \u0627\u0633\u0679\u06cc\u0645 \u0633\u06cc\u0644 \u06a9\u06d2 \u0641\u0646\u06a9\u0634\u0646 \u06a9\u0648 \u0679\u06be\u06cc\u06a9 \u06a9\u06cc\u0627 \u062c\u0627\u0633\u06a9\u062a\u0627 \u06c1\u06d2\u060c \u0644\u06cc\u06a9\u0646 \u06cc\u06c1 \u0628\u0627\u0644\u063a \u0627\u0633\u0679\u06cc\u0645 \u0633\u06cc\u0644 \u06a9\u06cc \u062a\u06be\u06a9\u0646 \u06a9\u0627 \u0628\u0627\u0639\u062b \u0628\u0646 \u0633\u06a9\u062a\u0627 \u06c1\u06d2\u061f
\u062c\u0648\u0627\u0628:<\/span> <\/strong>\u06c1\u0645\u0627\u0631\u06d2 \u067e\u0627\u0633 \u06a9\u0648\u0626\u06cc \u0688\u06cc\u0679\u0627 \u0646\u06c1\u06cc\u06ba \u06c1\u06d2 \u062c\u0648 \u0627\u0633 \u0633\u0648\u0627\u0644 \u06a9\u0627 \u062c\u0648\u0627\u0628 \u062f\u06d2 \u0633\u06a9\u06d2\u06d4<\/p>\n

[\/et_pb_toggle][et_pb_toggle title=”To Dr. Colin Stewart: 8 Questions and Answers for Dr. Stewart listed below.” open_toggle_background_color=”#f7f7f7″ closed_toggle_text_color=”#ffffff” closed_toggle_background_color=”#00b2e2″ icon_color=”#ffc15e” open_icon_color=”#ffc15e” admin_label=”Dr. Colin Stewart” _builder_version=”4.16″ _module_preset=”default” title_text_color=”#00b2e2″ title_font=”||||||||” background_color=”#ffffff” custom_margin=”||25px” custom_padding=”|50px||50px||true” border_width_all=”0px” global_colors_info=”{}”]<\/p>\n

\"\"\u0633\u0648\u0627\u0644:<\/strong><\/span> Mei \u06a9\u06cc \u0637\u0631\u0641 \u0633\u06d2: cardiomyocyte \u06a9\u06cc \u0637\u0631\u062d \u0644\u06af\u062a\u0627 \u06c1\u06d2\u060c \u062e\u0648\u0628\u0635\u0648\u0631\u062a \u062f\u0627\u063a!
Abby Buchwalter \u06a9\u06cc \u0637\u0631\u0641 \u0633\u06d2: \u06a9\u06cc\u0627 \u063a\u0627\u0644\u0628 \u0645\u0646\u0641\u06cc Sun1 \u0627\u0638\u06c1\u0627\u0631 \u062a\u0645\u0627\u0645 LINC \u06a9\u0645\u067e\u0644\u06cc\u06a9\u0633 \u06a9\u0648 \u0645\u062a\u0627\u062b\u0631 \u06a9\u0631\u062a\u0627 \u06c1\u06d2\u060c \u0628\u0634\u0645\u0648\u0644 Sun2 \u06a9\u06d2 \u0630\u0631\u06cc\u0639\u06d2 \u062b\u0627\u0644\u062b\u06cc \u06a9\u0631\u0646\u06d2 \u0648\u0627\u0644\u06d2\u061f
\u062c\u0648\u0627\u0628:<\/span> <\/strong>\u06c1\u0627\u06ba \u0648\u0679\u0631\u0648 \u0645\u06cc\u06ba \u0627\u0633 \u06a9\u06d2 \u062b\u0628\u0648\u062a \u0645\u0648\u062c\u0648\u062f \u06c1\u06cc\u06ba \u06a9\u06c1 NE \u0645\u06cc\u06ba \u062a\u0645\u0627\u0645 Nesprins \u06a9\u0648 DNSUN1 \u06a9\u06d2 \u0630\u0631\u06cc\u0639\u06d2 \u0628\u06d2 \u06af\u06be\u0631 \u06a9\u06cc\u0627 \u062c\u0627 \u0633\u06a9\u062a\u0627 \u06c1\u06d2\u06d4<\/p>\n

\u0633\u0648\u0627\u0644:<\/strong><\/span> Suet Nee Chen \u0633\u06d2: AAV9-SunDn \u0637\u0648\u06cc\u0644 \u0645\u062f\u062a\u06cc \u0627\u062b\u0631\u0627\u062a \u0645\u0631\u062a\u0628 \u06a9\u0631\u0646\u06d2 \u06a9\u06d2 \u0642\u0627\u0628\u0644 \u06a9\u06cc\u0633\u06d2 \u0627\u0648\u0631 \u06a9\u06cc\u0627 \u0637\u0631\u06cc\u0642\u06c1 \u06a9\u0627\u0631 \u06c1\u06d2\u061f \u0622\u067e \u0646\u06d2 \u06a9\u0633 \u0639\u0645\u0631 \u0645\u06cc\u06ba LMNA \u0627\u062a\u067e\u0631\u06cc\u0648\u0631\u062a\u06cc \u0686\u0648\u06c1\u0648\u06ba \u06a9\u0648 AAV9-Sun1DN \u0627\u0646\u062c\u06cc\u06a9\u0634\u0646 \u0644\u06af\u0627\u06cc\u0627 \u062a\u06be\u0627\u061f
\u062c\u0648\u0627\u0628:<\/span> <\/strong>\u06c1\u0645 \u0646\u06d2 \u0688\u06cc \u0627\u06cc\u0646 \u0627\u06cc\u0633 \u06cc\u0648 \u0627\u06cc\u0646 1 \u0627\u06d2 \u0627\u06d2 \u0648\u06cc \u06a9\u0648 \u0644\u06cc\u0645\u06cc\u0646 \u0627\u06d2 \u06a9\u0648 \u062d\u0630\u0641 \u06a9\u0631\u0646\u06d2 \u06a9\u06d2 \u0644\u0626\u06d2 \u06a9\u0631 \u0631\u06cc\u06a9\u0648\u0645\u0628\u06cc\u0646\u06cc\u0633 \u06a9\u0648 \u0622\u0645\u0627\u062f\u06c1 \u06a9\u0631\u0646\u06d2 \u06a9\u06d2 \u0627\u06cc\u06a9 \u062f\u0646 \u0628\u0639\u062f \u0627\u0646\u062c\u06cc\u06a9\u0634\u0646 \u0644\u06af\u0627\u06cc\u0627\u06d4 \u06c1\u0645\u0627\u0631\u06d2 \u067e\u0627\u0633 \u0688\u06cc\u0679\u0627 \u06c1\u06d2 \u06a9\u06c1 AAV \u06a9\u06d2 \u0630\u0631\u06cc\u0639\u06d2 \u0641\u0631\u0627\u06c1\u0645 \u06a9\u0631\u062f\u06c1 DNSUN1 \u0627\u0646\u062c\u06cc\u06a9\u0634\u0646 \u06a9\u06d2 \u0627\u06cc\u06a9 \u0633\u0627\u0644 \u0628\u0639\u062f \u06a9\u0627\u0631\u0688\u06cc\u0648 \u0645\u0627\u06cc\u0648\u0633\u0627\u0626\u0679\u0633 \u0645\u06cc\u06ba \u0638\u0627\u06c1\u0631 \u06c1\u0648\u062a\u0627 \u0631\u06c1\u062a\u0627 \u06c1\u06d2\u06d4 \u0627\u0628 \u06c1\u0645 \u062e\u0648\u0631\u0627\u06a9\/\u0648\u0642\u062a\/\u0631\u062f\u0639\u0645\u0644 \u06a9\u06d2 \u062a\u062c\u0631\u0628\u0627\u062a \u06a9\u0631 \u0631\u06c1\u06d2 \u06c1\u06cc\u06ba \u062c\u0628 \u06a9\u06c1 \u06c1\u0645 \u062f\u0648\u0628\u0627\u0631\u06c1 \u0644\u06cc\u0628 \u0645\u06cc\u06ba \u0622 \u06af\u0626\u06d2 \u06c1\u06cc\u06ba \u0627\u0648\u0631 \u06a9\u0627\u0641\u06cc \u0645\u0642\u062f\u0627\u0631 \u0645\u06cc\u06ba \u0627\u067e\u0646\u0627 AAV \u0628\u0646\u0627 \u0633\u06a9\u062a\u06d2 \u06c1\u06cc\u06ba\u06d4<\/p>\n

\u0633\u0648\u0627\u0644:<\/span><\/strong> \u0645\u0627\u0631\u0679\u0646 \u0628\u0631\u06af \u0633\u06d2\u060c \u0648\u0627\u0626\u0633\u0648\u0631\u0688\u0641\u0631\u0627\u0646\u0688 \u06a9\u0645\u06cc\u0679\u0646 \u0641\u0627\u0631 \u0641\u0627\u0631\u0633\u06a9\u0646\u06af: \u0622\u067e \u06a9\u06d2 \u062e\u06cc\u0627\u0644 \u0645\u06cc\u06ba \u0622\u067e \u06a9\u06d2 Lmna \u0646\u0627\u06a9 \u0622\u0624\u0679 \u062a\u062c\u0631\u0628\u0627\u062a \u0645\u06cc\u06ba \u063a\u06cc\u0631 \u062d\u0627\u0636\u0631 lamin A \u0628\u0645\u0642\u0627\u0628\u0644\u06c1 lamin C \u06a9\u0627 \u0631\u0634\u062a\u06c1 \u062f\u0627\u0631 \u062d\u0635\u06c1 \u06a9\u06cc\u0627 \u06c1\u06d2\u061f
\u062c\u0648\u0627\u0628:<\/strong><\/span> \u0645\u062c\u06be\u06d2 \u0627\u0633 \u06a9\u06d2 \u0628\u0627\u0631\u06d2 \u0645\u06cc\u06ba \u06cc\u0642\u06cc\u0646 \u0646\u06c1\u06cc\u06ba \u06c1\u06d2 \u0644\u06cc\u06a9\u0646 Sun1 LaminA \u06a9\u06d2 \u0633\u0627\u062a\u06be \u0628\u0627\u062a \u0686\u06cc\u062a \u06a9\u0631\u062a\u0627 \u06c1\u06d2 \u0627\u0648\u0631 HGPS \u0686\u0648\u06c1\u0648\u06ba \u0645\u06cc\u06ba \u0634\u0631\u0627\u06a9\u062a \u062a\u0645\u0627\u0645 LaminA \u06c1\u0648\u0646\u06cc \u0686\u0627\u06c1\u06cc\u06d2 (\u062c\u0633 \u0633\u06d2 \u067e\u0631\u0648\u062c\u0631\u06cc\u0646 \u0627\u062e\u0630 \u06a9\u06cc\u0627 \u06af\u06cc\u0627 \u06c1\u06d2)<\/p>\n

\u0633\u0648\u0627\u0644:<\/span><\/strong> jcampisi \u0633\u06d2: SUN1 KO \u06cc\u0627 \u06c1\u06cc\u0679\u0633 \u0645\u06cc\u06ba \u0645\u0648\u062a \u06a9\u06cc \u0648\u062c\u06c1 \u06a9\u06cc\u0627 \u06c1\u06d2\u061f
\u062c\u0648\u0627\u0628:<\/strong><\/span> \u0627\u0686\u06be\u0627 \u0633\u0648\u0627\u0644 \u06c1\u0645 \u0627\u0628\u06be\u06cc \u062a\u06a9 \u0646\u06c1\u06cc\u06ba \u062c\u0627\u0646\u062a\u06d2 \u0644\u06cc\u06a9\u0646 \u0641\u06cc \u0627\u0644\u062d\u0627\u0644 \u06a9\u0686\u06be \u06a9\u0646\u06a9\u0627\u0644 \u06a9\u06d2 \u067e\u0679\u06be\u0648\u06ba \u06a9\u06d2 \u06af\u0631\u0648\u067e \u067e\u0631 \u0634\u0628\u06c1 \u06c1\u06d2 \u06c1\u0645\u06cc\u06ba \u0645\u0631\u062a\u06d2 \u06c1\u0648\u0626\u06d2 \u0686\u0648\u06c1\u0648\u06ba \u06a9\u06d2 \u0645\u06c1\u0630\u0628 \u06c1\u0633\u0679\u0648 \u067e\u06cc\u062a\u06be\u0648 \u062a\u062c\u0632\u06cc\u06c1 \u06a9\u06cc \u0636\u0631\u0648\u0631\u062a \u06c1\u06d2\u06d4<\/p>\n

\u0633\u0648\u0627\u0644: <\/span><\/strong>Tom Misteli \u0633\u06d2: \u06a9\u0648\u0644\u0646: \u06a9\u06cc\u0627 \u0622\u067e \u0646\u06d2 Lmna\/Sun \u062c\u0627\u0646\u0648\u0631\u0648\u06ba \u0645\u06cc\u06ba \u0633\u06cc\u0644\u0648\u0644\u0631 \u062a\u0646\u0627\u0624 \u06a9\u06d2 \u0631\u062f\u0639\u0645\u0644 \u06a9\u06d2 \u0631\u0627\u0633\u062a\u0648\u06ba \u0645\u06cc\u06ba \u062a\u0628\u062f\u06cc\u0644\u06cc\u0627\u06ba \u062f\u06cc\u06a9\u06be\u06cc \u06c1\u06cc\u06ba\u061f
\u062c\u0648\u0627\u0628:<\/strong><\/span> \u06c1\u0645 \u0646\u06d2 \u0627\u0628\u06be\u06cc \u062a\u06a9 \u0627\u0646 \u0686\u0648\u06c1\u0648\u06ba \u0645\u06cc\u06ba \u062a\u0646\u0627\u0624 \u06a9\u06d2 \u0631\u062f\u0639\u0645\u0644 \u06a9\u06d2 \u062c\u06cc\u0646\/\u0645\u0627\u0631\u06a9\u0631 \u06a9\u06cc \u067e\u06cc\u0645\u0627\u0626\u0634 \u0646\u06c1\u06cc\u06ba \u06a9\u06cc \u06c1\u06d2\u06d4<\/p>\n

\u0633\u0648\u0627\u0644: \u0688\u06cc\u0644\u0641\u0627\u0626\u0646 \u0644\u06cc\u0631\u06cc\u0648 \u0633\u06d2: \u06a9\u06cc\u0627 \u0622\u067e HGPS \u0645\u0631\u06cc\u0636\u0648\u06ba \u0645\u06cc\u06ba DNSUN1 \u06a9\u06d2 \u0633\u0627\u062a\u06be \u0635\u0631\u0641 \u062f\u0644 \u06a9\u0648 \u0646\u0634\u0627\u0646\u06c1 \u0628\u0646\u0627\u0646\u06d2 \u06a9\u0627 \u062a\u0635\u0648\u0631 \u06a9\u0631\u06cc\u06ba \u06af\u06d2\u061f
\u062c\u0648\u0627\u0628:<\/strong><\/span> \u06a9\u0627\u0631\u0688\u06cc\u0648 \u0645\u0627\u06cc\u0648\u0633\u0627\u0626\u0679 \u0645\u062e\u0635\u0648\u0635 \u067e\u0631\u0648\u0645\u0648\u0679\u0631 \u06a9\u06d2 \u0633\u06cc\u0631\u0648 \u0679\u0627\u0626\u067e \u0627\u0648\u0631 \u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u06a9\u06d2 \u067e\u06cc\u0634 \u0646\u0638\u0631 \u06cc\u06c1 \u0645\u0645\u06a9\u0646 \u06c1\u06d2\u06d4 \u0648\u06c1 \u062a\u062c\u0631\u0628\u0627\u062a \u0627\u0633 \u0648\u0642\u062a \u062c\u0627\u0631\u06cc \u06c1\u06cc\u06ba\u06d4<\/p>\n

\u0633\u0648\u0627\u0644:<\/span><\/strong>Yuexia Wang \u0633\u06d2: KO SUN1 \u06a9\u0648 \u06c1\u0648\u0645\u0648\u0632\u0627\u0626\u06af\u0633 G609G \u0686\u0648\u06c1\u0648\u06ba \u067e\u0631 \u06a9\u0645 \u0641\u0627\u0626\u062f\u06c1 \u06a9\u06cc\u0648\u06ba \u06c1\u06d2\u061f
\u062c\u0648\u0627\u0628:<\/strong><\/span> \u0634\u0627\u06cc\u062f \u0627\u0633 \u0644\u06cc\u06d2 \u06a9\u06c1 \u06c1\u0648\u0645\u0648\u0632\u0627\u0626\u06af\u0633 \u0686\u0648\u06c1\u06d2 \u0632\u06cc\u0627\u062f\u06c1 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0646 \u06a9\u0627 \u0627\u0638\u06c1\u0627\u0631 \u06a9\u0631 \u0631\u06c1\u06d2 \u06c1\u06cc\u06ba\u06d4 \u06c1\u0645 \u0627\u067e\u0646\u06d2 \u062c\u06cc\u0646\u06cc\u0627\u062a\u06cc \u062a\u062c\u0631\u0628\u0627\u062a \u0645\u06cc\u06ba heterozygotes v homozygotes \u06a9\u06d2 \u0631\u062f\u0639\u0645\u0644 \u06a9\u0627 \u0627\u062b\u0631 \u062f\u06cc\u06a9\u06be\u062a\u06d2 \u06c1\u06cc\u06ba\u06d4<\/p>\n

\u0633\u0648\u0627\u0644:<\/span><\/strong>\u0631\u0648\u0644\u06cc\u0646\u0688 \u0641\u0648\u0632\u0646\u0631 \u0633\u06d2: \u06c1\u06cc\u0644\u0648 \u06a9\u0648\u0644\u0646\u060c \u0627\u0686\u06be\u06cc \u0628\u0627\u062a\u06d4 HGPS \u0645\u06cc\u06ba upregulated SUN1 \u06a9\u0627 \u0645\u0646\u0641\u06cc \u0627\u062b\u0631 \u06a9\u06cc\u0627 \u06c1\u06d2\u061f \u0631\u0648\u0644\u06cc\u0646\u0688
\u062c\u0648\u0627\u0628:<\/strong><\/span> \u0645\u0645\u06a9\u0646\u06c1 \u0637\u0648\u0631 \u067e\u0631 LINC \u06a9\u0645\u067e\u0644\u06cc\u06a9\u0633 \u06a9\u06d2 \u0633\u0627\u062a\u06be MT \u0646\u06cc\u0679 \u0648\u0631\u06a9 \u06a9\u06cc \u0648\u0627\u0628\u0633\u062a\u06af\u06cc \u0645\u06cc\u06ba \u0627\u0636\u0627\u0641\u06c1 \u06c1\u0648\u0627 \u06c1\u06d2\u06d4 \u062b\u0642\u0627\u0641\u062a\u0648\u06ba \u06a9\u06d2 \u062e\u0644\u06cc\u0648\u06ba \u0645\u06cc\u06ba \u0633\u0648\u0631\u062c\/\u0646\u06cc\u0633\u067e\u0631\u06cc\u0646 \u06a9\u06d2 \u0627\u0638\u06c1\u0627\u0631 \u0645\u06cc\u06ba \u0627\u0636\u0627\u0641\u06c1 \u0646\u06cc\u0648\u06a9\u0644\u06cc\u0626\u0631 \u067e\u0648\u0632\u06cc\u0634\u0646\u0646\u06af \u0627\u0648\u0631 \u0633\u06cc\u0644 \u06a9\u06cc \u0645\u0646\u062a\u0642\u0644\u06cc \u06a9\u0648 \u0645\u062a\u0627\u062b\u0631 \u06a9\u0631\u062a\u0627 \u06c1\u06d2\u06d4<\/p>\n

[\/et_pb_toggle][et_pb_image src=”https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2020\/07\/Basso.Peraut-Family.jpg” title_text=”Basso.Peraut-Family” align=”center” admin_label=”families” _builder_version=”4.16″ _module_preset=”default” custom_margin=”5px||15px||false|false” global_colors_info=”{}”][\/et_pb_image][et_pb_toggle title=”A Sampling from the Chat Comments!” open_toggle_background_color=”#f7f7f7″ closed_toggle_text_color=”#ffffff” closed_toggle_background_color=”#00b2e2″ icon_color=”#ffc15e” open_icon_color=”#ffc15e” admin_label=”Sampling from the Chat Comments!” _builder_version=”4.16″ _module_preset=”default” title_text_color=”#00b2e2″ title_font=”||||||||” background_color=”#ffffff” custom_margin=”||25px” custom_padding=”|50px||50px||true” border_width_all=”0px” global_colors_info=”{}”]<\/p>\n

\u0628\u0627\u0633\u0648 \u0627\u0648\u0631 \u067e\u06cc\u0631\u0627\u0624\u0679 \u0641\u06cc\u0645\u0644\u06cc \u0633\u06d2 \u0645\u0644\u0646\u0627 \u0627\u0639\u0632\u0627\u0632\u06d4 \u0627\u067e\u0646\u0627 \u0633\u0641\u0631 \u0628\u0627\u0646\u0679\u0646\u06d2 \u06a9\u06d2 \u0644\u06cc\u06d2 \u0622\u067e \u06a9\u0627 \u0634\u06a9\u0631\u06cc\u06c1\u06d4 \u0622\u067e \u0648\u0627\u0642\u0639\u06cc \u0627\u0648\u0631 \u067e\u0631\u06cc\u0631\u062a\u0627 \u06c1\u06cc\u06ba!<\/p>\n

\u0648\u0631\u06a9\u0634\u0627\u067e \u06a9\u0627 \u062d\u0635\u06c1 \u0628\u0646\u0646\u06d2 \u0627\u0648\u0631 \u067e\u0631\u0648\u062c\u06cc\u0631\u06cc\u0627 \u06a9\u06d2 \u0633\u0627\u062a\u06be \u0627\u067e\u0646\u06d2 \u0645\u062a\u0627\u062b\u0631 \u06a9\u0646 \u0633\u0641\u0631 \u06a9\u0627 \u0627\u0634\u062a\u0631\u0627\u06a9 \u06a9\u0631\u0646\u06d2 \u06a9\u06d2 \u0644\u06cc\u06d2 \u0633\u0627\u0645\u06cc \u0627\u0648\u0631 \u0627\u0644\u06cc\u06af\u0632\u06cc\u0646\u0688\u0631\u0627 \u06a9\u06d2 \u062e\u0627\u0646\u062f\u0627\u0646 \u06a9\u0627 \u0634\u06a9\u0631\u06cc\u06c1!<\/p>\n

\u0627\u0641\u0642 \u067e\u0631 \u0645\u0646\u0638\u0648\u0631\u06cc \u06a9\u06d2 \u0633\u0627\u062a\u06be \u0634\u0627\u0646\u062f\u0627\u0631 \u067e\u06cc\u0634\u0631\u0641\u062a \u0627\u06cc\u06af\u0631\u06d4<\/p>\n

\u06a9\u06cc\u0627 \u06c1\u0645 \u0627\u0633 \u0633\u06cc\u0634\u0646 \u06a9\u0648 \u06c1\u0641\u062a\u06d2 \u06a9\u06d2 \u0622\u062e\u0631 \u062a\u06a9 \u0628\u0691\u06be\u0627 \u0633\u06a9\u062a\u06d2 \u06c1\u06cc\u06ba \u0627\u0648\u0631 \u0628\u062d\u062b \u06a9\u0648 \u062c\u0627\u0631\u06cc \u0631\u06a9\u06be \u0633\u06a9\u062a\u06d2 \u06c1\u06cc\u06ba\u061f (\u0622\u067e \u06a9\u0627 \u0634\u06a9\u0631\u06cc\u06c1\u060c \u0627\u06cc\u06a9 \u0627\u0648\u0631 \u0633\u0628!)\u00a0<\/p>\n

\u06cc\u06c1 \u0648\u0631\u06a9\u0634\u0627\u067e \u0646\u0627\u0642\u0627\u0628\u0644 \u06cc\u0642\u06cc\u0646 \u062a\u06be\u0627\u06d4 \u0645\u06cc\u06ba PRF \u06a9\u0648 \u0627\u0633 \u0639\u0638\u06cc\u0645 \u0633\u0631\u06af\u0631\u0645\u06cc \u06a9\u0648 \u0627\u0646\u062c\u0627\u0645 \u062f\u06cc\u0646\u06d2 \u06a9\u06d2 \u0639\u0632\u0645 \u06a9\u06d2 \u0644\u06cc\u06d2 \u0645\u0628\u0627\u0631\u06a9\u0628\u0627\u062f \u067e\u06cc\u0634 \u06a9\u0631\u062a\u0627 \u06c1\u0648\u06ba\u06d4 \u0628\u0644\u0627 \u0634\u0628\u06c1\u060c \u0627\u0633 \u0648\u0631\u06a9\u0634\u0627\u067e \u0646\u06d2 \u0645\u062c\u06be\u06d2 \u0627\u067e\u0646\u06d2 \u0645\u0633\u062a\u0642\u0628\u0644 \u06a9\u06d2 \u0644\u06cc\u06d2 \u0628\u06c1\u062a \u0633\u06d2 \u0639\u0644\u0645 \u0633\u06d2 \u0628\u06be\u0631 \u062f\u06cc\u0627\u06d4 \u06cc\u06c1 \u062d\u06cc\u0631\u062a \u0627\u0646\u06af\u06cc\u0632 \u062a\u06be\u0627\u06d4 \u06c1\u0645 \u0645\u0644 \u06a9\u0631 \u0639\u0644\u0627\u062c \u062a\u0644\u0627\u0634 \u06a9\u0631\u06cc\u06ba \u06af\u06d2!<\/p>\n

PRF \u0645\u06cc\u0679\u0646\u06af\u0632 \u0645\u06cc\u06ba \u062f\u0644\u0686\u0633\u067e \u0633\u0627\u0626\u0646\u0633 \u0633\u06d2 \u06c1\u0645\u06cc\u0634\u06c1 \u0645\u062a\u0627\u062b\u0631 \u06c1\u0648\u06ba\u06d4 \u0627\u0633 \u0648\u0631\u0686\u0648\u0626\u0644 \u0641\u0627\u0631\u0645\u06cc\u0679 \u0645\u06cc\u06ba \u0628\u06be\u06cc \u06a9\u0645\u06cc\u0648\u0646\u0679\u06cc \u0648\u0631\u06a9\u0634\u0627\u067e \u06a9\u06d2 \u062a\u062c\u0631\u0628\u06d2 \u06a9\u0648 \u0645\u062d\u0641\u0648\u0638 \u0631\u06a9\u06be\u0646\u06d2 \u06a9\u06d2 \u0644\u06cc\u06d2 \u0645\u0646\u062a\u0638\u0645\u06cc\u0646 \u06a9\u0648 \u0628\u06c1\u062a \u0634\u06a9\u0631\u06cc\u06c1!<\/p>\n

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