{"id":1012,"date":"2017-02-27T21:28:49","date_gmt":"2017-02-27T21:28:49","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?page_id=1012"},"modified":"2026-04-03T13:57:51","modified_gmt":"2026-04-03T17:57:51","slug":"prf-cell-and-tissue-bank-publications","status":"publish","type":"page","link":"https:\/\/www.progeriaresearch.org\/zh\/prf-cell-and-tissue-bank-publications\/","title":{"rendered":"PRF \u7ec6\u80de\u548c\u7ec4\u7ec7\u5e93\u51fa\u7248\u7269"},"content":{"rendered":"

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PRF \u7ec6\u80de\u548c\u7ec4\u7ec7<\/h1>\n

\u94f6\u884c\u520a\u7269<\/h1>\n

 <\/p>\n

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\u5229\u7528\u4ee5\u4e0b\u6750\u6599\u51fa\u7248\u7684\u51fa\u7248\u7269
<\/b>\u65e9\u8870\u75c7\u7814\u7a76\u57fa\u91d1\u4f1a\u7ec6\u80de\u548c\u7ec4\u7ec7\u5e93<\/b><\/p>\n

<\/a>\u65e9\u8870\u75c7\u7814\u7a76\u57fa\u91d1\u4f1a (PRF) \u4e3a\u4e16\u754c\u5404\u5730\u7684\u7814\u7a76\u4eba\u5458\u63d0\u4f9b\u7ec6\u80de\u7cfb\u3001\u751f\u7269\u6750\u6599\u548c lonafarnib\uff0c\u4ee5\u4fc3\u8fdb\u5bf9\u65e9\u8870\u75c7\u548c\u5176\u4ed6\u8870\u8001\u76f8\u5173\u75be\u75c5\u7684\u7814\u7a76\u3002\u4e0b\u9762\u5217\u51fa\u4e86\u5229\u7528 PRF \u7ec6\u80de\u548c\u7ec4\u7ec7\u5e93\u6750\u6599\u7684\u51fa\u7248\u7269\u3002\u8be5\u5217\u8868\u6309\u7ec6\u80de\u7cfb\u548c\u5176\u4ed6\u751f\u7269\u6837\u672c\u7c7b\u578b\u5206\u7c7b\uff0c\u4ee5\u65b9\u4fbf\u7814\u7a76\u4eba\u5458\u67e5\u9605\u3002<\/p>\n

<\/p>\n

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\n\n\n\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t
HGADFN001<\/a><\/td>HGADFN003<\/a><\/td>HGADFN005<\/a><\/td>\n<\/tr>\n
HGADFN008<\/a><\/td>HGADFN014<\/a><\/td>HGMDFN090<\/a><\/td>\n<\/tr>\n
HGADFN122<\/a><\/td>HGADFN127<\/a><\/td>HGADFN136<\/a><\/td>\n<\/tr>\n
HGADFN143<\/a><\/td>\u54c8\u5c14\u6ee8GADFN155<\/a><\/td>HGADFN164<\/a><\/td>\n<\/tr>\n
HGADFN167<\/a><\/td>HGFDFN168<\/a><\/td> HGADFN169<\/a><\/td>\n<\/tr>\n
HGADFN178<\/a><\/td>HGADFN188<\/a><\/td>HGADFN271<\/a><\/td>\n<\/tr>\n
HGADFN367<\/a><\/td>HGMDFN368<\/a><\/td>HGFDFN369<\/a><\/td>\n<\/tr>\n
\u54c8\u5c14\u6ee8GADFN370<\/a><\/td>HGMDFN371<\/a><\/td>\u54c8\u5c14\u6ee8GADFN496<\/a><\/td>\n<\/tr>\n
HGMDFN717<\/a><\/td>HGMDFN718<\/a><\/td>\u578b\u53f7\uff1aPSADFN086<\/a><\/td>\n<\/tr>\n
\u5e15\u8428\u5fb7\u592b\u7eb3 004<\/a><\/td>\u578b\u53f7\uff1aPSADFN257<\/a><\/td>psadfn317<\/a><\/td>\n<\/tr>\n
\u578b\u53f7\uff1aPSADFN318<\/a><\/td>psfdfn319<\/a><\/td>\u666e\u9002\u914d\u5361<\/a><\/td>\n<\/tr>\n
PSMDFN326<\/a><\/td>PSDFN327 \u578b<\/a><\/td> PSMDFN346<\/a><\/td>\n<\/tr>\n
psadfn363 \u578b\u53f7<\/a><\/td>psadfn373<\/a><\/td>PSADFN423 \u578b <\/a><\/td>\n<\/tr>\n
\u578b\u53f7\uff1aPSADFN485 <\/a><\/td>\u578b\u53f7\uff1aPSADFN542 <\/a><\/td>\u578b\u53f7\uff1aPSADFN386<\/a><\/td>\n<\/tr>\n
PSMDFN371<\/a><\/td>PSMDFN387<\/a><\/td>psfdfn388<\/a><\/td>\n<\/tr>\n
\u578b\u53f7\uff1aPSADFN392<\/a><\/td>PSMDFN393<\/a><\/td><\/td>\n<\/tr>\n
PSDFN394<\/a><\/td>\u578b\u53f7\uff1aPSADFN414<\/a><\/td>\u805a\u82ef\u4e59\u70ef\u78fa\u9178\u94a0<\/a><\/td>\n<\/tr>\n
HGALBV009<\/a><\/td>HGMLBV010<\/a><\/td>HGALBV011<\/a><\/td>\n<\/tr>\n
HGMLBV013<\/a><\/td>HGFLBV021<\/a><\/td>HGMLBV023<\/a><\/td>\n<\/tr>\n
HGFLBV031<\/a><\/td>HGFLBV050<\/a><\/td>HGALBV057<\/a><\/td>\n<\/tr>\n
HGMLBV058<\/a><\/td>HGSLBV059<\/a><\/td>HGMLBV066<\/a><\/td>\n<\/tr>\n
HGFLBV067<\/a><\/td>HGALBV071<\/a><\/td>HGMLBV081<\/a><\/td>\n<\/tr>\n
HGFLBV082<\/a><\/td>HGADFN003 iPS1B<\/a><\/td>HGADFN003 iPS1C<\/a><\/td>\n<\/tr>\n
HGADFN003 iPS1D<\/a><\/td>HGMDFN090 iPS1B<\/a><\/td>HGMDFN090 iPS1C<\/a><\/td>\n<\/tr>\n
HGADFN167 iPS1J<\/a><\/td>HGADFN167 iPS1Q<\/a><\/td>HGFDFN168 iPS1D2<\/a><\/td>\n<\/tr>\n
HGFDFN168 iPS1P<\/a><\/td>\u8131\u6c27\u6838\u7cd6\u6838\u9178<\/a><\/td>\u5c38\u68c0\u7ec4\u7ec7<\/a><\/td>\n<\/tr>\n
\u7b49\u79bb\u5b50\u4f53<\/a><\/td>\u8840\u6e05<\/a><\/td><\/td>\n<\/tr>\n
\u8840\u6c89\u9ec4\u5c42<\/a><\/td>Zokinvy\uff08lonafarnib\uff09<\/a><\/td><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\u5bf9\u4e8e\u6309\u7ec6\u80de\u7cfb\u7eb3\u5165\u5217\u51fa\u7684\u51fa\u7248\u7269\uff0c \u70b9\u51fb\u8fd9\u91cc\u3002<\/a><\/strong><\/p>\n

\u5bf9\u4e8e\u6309\u751f\u7269\u6837\u672c\u5305\u542b\u60c5\u51b5\u5217\u51fa\u7684\u51fa\u7248\u7269\uff0c \u70b9\u51fb\u8fd9\u91cc\u3002<\/a><\/strong><\/p>\n

\u5bf9\u4e8e\u6309 Zokinvy (lonafarnib) \u6536\u5f55\u7684\u51fa\u7248\u7269\uff0c \u70b9\u51fb\u8fd9\u91cc\u3002<\/a><\/strong><\/p>\n

[\/et_pb_text][et_pb_text]admin_label=\u201dHGADFN001\u2033 module_id=\u201dHGADFN001\u2033 _builder_version=\u201d4.16\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

HGADFN001<\/strong><\/h4>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d MMP-3 \u7684\u5e74\u9f84\u4f9d\u8d56\u6027\u4e27\u5931\u3002<\/a>
Harten IA\u3001Zahr RS\u3001Lemire JM\u3001Machan JT\u3001Moses MA\u3001Doiron RJ\u3001Curatolo AS\u3001Rothman FG\u3001Wight TN\u3001Toole BP\u3001Gordon LB\u3002\u00a0\u8001\u5e74\u751f\u7269\u79d1\u5b66\u4e0e\u533b\u5b66\u6742\u5fd7<\/em>. 2011\u5e7411\u6708;66(11):1201-7.<\/p>\n

\u5bfc\u81f4\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u7684\u5c42\u86cb\u767d A \u7a81\u53d8\u5f62\u5f0f\u662f\u4eba\u7c7b\u76ae\u80a4\u7ec6\u80de\u8870\u8001\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002<\/a>
\u9ea6\u514b\u6797\u6258\u514b D\u3001\u62c9\u7279\u7eb3 D\u3001\u6d1b\u5e93\u683c M\u3001\u6b27\u6587\u65af DM\u3001\u6208\u767b LB\u3001\u67ef\u6797\u65af FS\u3001\u8d3e\u5df4\u5229 K.\u00a0PLoS\u7efc\u5408<\/em>. 2007 \u5e74 12 \u6708 5 \u65e5;2(12):e1269\u3002<\/p>\n

\u901a\u8fc7\u6297\u5c42\u86cb\u767d A G608G \u6297\u4f53\u68c0\u6d4b\uff0c\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u7a81\u53d8\u5c42\u86cb\u767d A \u4e3b\u8981\u9488\u5bf9\u4eba\u7c7b\u8840\u7ba1\u7ec6\u80de\u3002<\/a>
\u9ea6\u514b\u6797\u6258\u514b D\u3001\u6208\u767b LB\u3001\u8d3e\u5df4\u5229 K.\u00a0\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a\u3002<\/em>\u00a02006 \u5e74 2 \u6708 14 \u65e5\uff1b103(7):2154-9\u3002<\/p>\n

\u5728\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u771f\u76ae\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\uff0c\u805a\u96c6\u86cb\u767d\u805a\u7cd6\u7684\u8868\u8fbe\u663e\u8457\u4e14\u5f02\u5e38\u4e0a\u8c03\u3002<\/a>
Lemire JM\u3001Patis C\u3001Gordon LB\u3001Sandy JD\u3001Toole BP\u3001Weiss AS\u3002\u00a0\u673a\u68b0\u8001\u5316\u5f00\u53d1\u3002<\/em>\u00a02006\u5e748\u6708;127(8):660-9\u3002<\/p>\n

\u901a\u8fc7\u836f\u7269\u6cbb\u7597\u633d\u6551\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u4e2d\u7684\u5f02\u67d3\u8272\u8d28\u7ec4\u7ec7\u3002<\/a>
Columbaro M\u3001Capanni C\u3001Mattioli E\u3001Novelli G\u3001Parnaik VK\u3001Squarzoni S\u3001Maraldi NM\u3001Lattanzi G\u3002\u00a0\u7ec6\u80de\u5206\u5b50\u751f\u547d\u79d1\u5b66\u3002<\/em>\u00a02005\u5e7411\u6708;62(22):2669-78\u3002<\/p>\n

\u5c42\u86cb\u767d A \u4e2d\u53cd\u590d\u53d1\u751f\u7684\u65b0\u751f\u70b9\u7a81\u53d8\u5bfc\u81f4\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u3002<\/a>
Eriksson M\u3001Brown WT\u3001Gordon LB\u3001Glynn MW\u3001Singer J\u3001Scott L\u3001Erdos MR\u3001Robbins CM\u3001Moses TY\u3001Berglund P\u3001Dutra A\u3001Pak E\u3001Durkin S\u3001Csoka AB\u3001Boehnke M\u3001Glover TW\u3001Collins FS\u3002\u00a0\u81ea\u7136\u3002<\/em>\u00a02003\u5e745\u670815\u65e5;423(6937):293-8\u3002<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN003″ module_id=”HGADFN003″ _builder_version=”4.27.5″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN003<\/strong><\/h4>\n

\u5bf9 Hutchinson-Gilford \u65e9\u8870\u75c7\u60a3\u8005\u7684\u8f6c\u5f55\u7ec4\u5206\u6790\u63ed\u793a\u4e86\u65e9\u8870\u86cb\u767d\u7684\u4e3b\u8981\u9776\u901a\u8def<\/a>
Vidak S\u3001Kim S\u3001Misteli T. \u9884\u5370\u672c\u3002\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125\u3002\u53d1\u8868\u4e8e2025\u5e749\u670820\u65e5\u3002doi:10.1101\/2025.09.18.677125<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d miR-145 \u548c miR-27b \u5931\u8c03\uff1a\u5bf9\u8102\u80aa\u751f\u6210\u7684\u5f71\u54cd<\/a>
Fenzl FQ\u3001Lederer EM\u3001Brumma L \u7b49\u3002 \u8001\u9f84\u5316\uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09<\/em>. 2025\u5e748\u670827\u65e5\u5728\u7ebf\u53d1\u8868\u3002doi:10.18632\/aging.206309<\/p>\n

miR-181a\u5bf9\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u60a3\u8005SIRT1\u8868\u8fbe\u548c\u8870\u8001\u7684\u5f71\u54cd<\/a>
Lederer EM\u3001Fenzl FQ\u3001Kr\u00fcger P\u3001Schroll M\u3001Hartinger R\u3001Djabali K. \u75be\u75c5<\/em>. 2025;13(8):245. \u53d1\u8868\u4e8e2025\u5e748\u67084\u65e5\u3002doi:10.3390\/diseases13080245<\/p>\n

\u589e\u5f3a\u7ec6\u80de\u7a33\u6001\uff1a\u9776\u5411\u690d\u7269\u5316\u5408\u7269\u589e\u5f3a\u6b63\u5e38\u548c\u8fc7\u65e9\u8870\u8001\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u7ec6\u80de\u5065\u5eb7\u529f\u80fd<\/a>
\u54c8\u5ef7\u683c R\u3001\u8f9b\u683c K\u3001\u83b1\u5f17\u91cc\u7279 J\u3001\u8d3e\u5df4\u5229 K. \u751f\u7269\u5206\u5b50<\/em>. 2024;14(10):1310\u30022024 \u5e74 10 \u6708 16 \u65e5\u53d1\u5e03\u3002doi:10.3390\/biom14101310<\/p>\n

\u751f\u957f\u7d20\u91ca\u653e\u80bd\u5ef6\u7f13\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u60a3\u8005\u7684\u8fc7\u65e9\u8870\u8001<\/a>
Ferreira-Marques M\u3001Carvalho A\u3001Franco AC \u7b49\u4eba\u3002\u751f\u957f\u7d20\u91ca\u653e\u80bd\u53ef\u5ef6\u7f13\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u60a3\u8005\u7684\u8fc7\u65e9\u8870\u8001 [2023 \u5e74 10 \u6708 19 \u65e5\u5728\u7ebf\u53d1\u8868]\u3002\u00a0\u8870\u8001\u7ec6\u80de<\/em>\u3002 2023\uff1be13983\u3002 doi\uff1a10.1111\/acel.13983<\/p>\n

\u5df4\u745e\u66ff\u5c3c\u548c FTI \u8054\u5408\u6cbb\u7597\u5bf9\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u5176\u4ed6\u8102\u80aa\u8425\u517b\u4e0d\u826f\u6838\u7ea4\u5c42\u86cb\u767d\u75c5\u60a3\u8005\u8102\u80aa\u751f\u6210\u7684\u5f71\u54cd<\/a>
Hartinger R\u3001Lederer EM\u3001Schena E\u3001Lattanzi G\u3001Djabali K. \u7ec6\u80de\u3002 2023\uff1b12(10):1350\u3002\u53d1\u5e03\u4e8e 2023 \u5e74 5 \u6708 9 \u65e5\u3002doi:10.3390\/cells12101350<\/p>\n

\u72ec\u7279\u7684\u65e9\u8870\u86cb\u767d C \u7aef\u80bd\u901a\u8fc7\u62ef\u6551 BUBR1 \u6539\u5584\u4e86\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u8868\u578b\u3002<\/a>
Zhang N, Hu Q, Sui T, Fu L, Zhang X, Wang Y, Zhu X, Huang B, Lu J, Li Z, Zhang Y. Nat Aging. 2023 \u5e74 2 \u6708;3(2):185-201\u3002doi: 10.1038\/s43587-023-00361-w\u30022023 \u5e74 2 \u6708 2 \u65e5\u7535\u5b50\u7248\u3002\u52d8\u8bef\u8868\uff0c\u8f7d\u4e8e\uff1aNat Aging\u30022023 \u5e74 5 \u6708 2 \u65e5\uff1bPMID\uff1a37118121\uff1bPMCID\uff1aPMC10154249\u3002<\/p>\n

Anti-hsa-miR-59 \u53ef\u7f13\u89e3\u5c0f\u9f20\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u76f8\u5173\u7684\u8fc7\u65e9\u8870\u8001<\/a>
\u80e1\u5029\u3001\u5f20\u5a1c\u3001\u968b\u5a77\u7b49\u3002[2022 \u5e74 11 \u6708 16 \u65e5\u5728\u7ebf\u53d1\u8868\uff0c\u63d0\u524d\u5370\u5237]\u3002\u00a0\u6b27\u6d32\u5206\u5b50\u751f\u7269\u5b66\u6742\u5fd7<\/em>\u3002 2022\uff1be110937\u3002 doi:10.15252\/embj.2022110937<\/p>\n

hTERT \u6c38\u751f\u5316 Hutchinson-Gilford \u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u7cfb\u7684\u5efa\u7acb\u548c\u9274\u5b9a<\/a>
Lin H\u3001Mensch J\u3001Haschke M \u7b49\u4eba\u3002Cells\u30022022\uff1b11(18)\uff1a2784\u30022022 \u5e74 9 \u6708 6 \u65e5\u53d1\u5e03\u3002doi:10.3390\/cells11182784<\/p>\n

MnTBAP \u548c\u5df4\u745e\u66ff\u5c3c\u6cbb\u7597\u5bf9\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u5f71\u54cd<\/a>
Vehns E\u3001Arnold R\u3001Djabali K. \u5236\u836f\u516c\u53f8\uff08\u5df4\u585e\u5c14\uff09\u3002 2022\uff1b15(8):945\u3002\u53d1\u5e03\u4e8e 2022 \u5e74 7 \u6708 29 \u65e5\u3002doi:10.3390\/ph15080945<\/p>\n

SerpinE1 \u9a71\u52a8\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u7684\u7ec6\u80de\u81ea\u4e3b\u81f4\u75c5\u4fe1\u53f7<\/a>
Catarinella G\u3001Nicoletti C\u3001Bracaglia A \u7b49\u4eba\u3002\u7ec6\u80de\u6b7b\u4ea1\u75be\u75c5\u3002 2022\uff1b13(8):737\u3002 2022 \u5e74 8 \u6708 26 \u65e5\u53d1\u5e03\u3002doi:10.1038\/s41419-022-05168-y<\/p>\n

\u9ad8\u65af\u66f2\u7387\u7a00\u91ca\u4e86\u6838\u5c42\uff0c\u6709\u5229\u4e8e\u6838\u7834\u88c2\uff0c\u5c24\u5176\u662f\u5728\u9ad8\u5e94\u53d8\u7387\u4e0b<\/a>
Pfeifer CR\u3001Tobin MP\u3001Cho S \u7b49\u4eba\u3002Nucleus\u30022022\uff1b13(1):129-143\u3002doi:10.1080\/19491034.2022.2045726<\/p>\n

\u57fa\u4e8e\u5f02\u620a\u4e8c\u70ef\u534a\u80f1\u6c28\u9178\u7fa7\u7532\u57fa\u8f6c\u79fb\u9176\u7684\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u6cbb\u7597<\/a>
\u9a6c\u79d1\u65af-\u62c9\u7c73\u7f57 B\u3001\u5409\u5c14-\u5965\u5c14\u591a\u6d85\u65af A\u3001\u9a6c\u6797-\u62c9\u83ab\u65af NI \u7b49\u4eba\u3002 \u7f8e\u56fd\u5316\u5b66\u5b66\u4f1a\u79d1\u5b66\u4e2d\u5fc3<\/em>. 2021\uff1b7(8):1300-1310\u3002doi:10.1021\/acscentsci.0c01698<\/p>\n

\u7aef\u7c92\u9176\u7597\u6cd5\u53ef\u9006\u8f6c\u65e9\u8870\u5c0f\u9f20\u7684\u8840\u7ba1\u8870\u8001\u5e76\u5ef6\u957f\u5176\u5bff\u547d<\/a>
Mojiri A\u3001Walther BK\u3001Jiang C \u7b49\u4eba\u3002[2021 \u5e74 8 \u6708 14 \u65e5\u63d0\u524d\u5728\u7ebf\u53d1\u8868]\u3002\u00a0\u6b27\u6d32\u5fc3\u810f\u6742\u5fd7<\/em>. 2021\uff1behab547.doi:10.1093\/eurheartj\/ehab547<\/p>\n

JAK-STAT \u6291\u5236\u5242\u5df4\u745e\u66ff\u5c3c\u53ef\u964d\u4f4e\u6cd5\u5462\u57fa\u8f6c\u79fb\u9176\u6291\u5236\u5242 Lonafarnib \u5bf9\u65e9\u8870\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027<\/a>
\u963f\u8bfa\u5fb7\u00b7R\u3001\u7ef4\u6069\u65af\u00b7E\u3001\u5170\u5fb7\u5c14\u00b7H\u3001\u8d3e\u5df4\u5229\u00b7K.\u00a0\u56fd\u9645\u5206\u5b50\u79d1\u5b66\u6742\u5fd7<\/em>. 2021;22(14):7474\u30022021 \u5e74 7 \u6708 12 \u65e5\u53d1\u5e03\u3002doi:10.3390\/ijms22147474<\/p>\n

\u65e9\u8870\u86cb\u767d\u8868\u8fbe\u5bf9\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u76ae\u80a4\u6e90\u6027\u524d\u4f53\u7ec6\u80de\u8102\u80aa\u751f\u6210\u7684\u5f71\u54cd<\/a>
\u7eb3\u5409\u8fea F\u3001\u514b\u9c81\u683c P\u3001\u8d3e\u5df4\u5229 K. \u5355\u5143\u683c<\/em>. 2021;10(7):1598\u30022021 \u5e74 6 \u6708 25 \u65e5\u53d1\u5e03\u3002doi:10.3390\/cells10071598<\/p>\n

\u901a\u8fc7\u76f8\u5206\u79bb\u5b9e\u73b0\u591a\u7ec4\u5206\u7ebf\u7c92\u4f53\u6838\u82f7\u7684\u81ea\u7ec4\u88c5\u3002
<\/a>Feric M\u3001Demarest TG\u3001Tian J\u3001Croteau DL\u3001Bohr VA\u3001Misteli T\u3002EMBO J\u30022021 \u5e74 3 \u6708 15 \u65e5\uff1b40(6):e107165\u3002doi: 10.15252\/embj.2020107165\u3002\u7535\u5b50\u7248 2021 \u5e74 2 \u6708 23 \u65e5\u3002PMID\uff1a33619770\uff1bPMCID\uff1aPMC7957436\u3002<\/p>\n

\u6838\u5b54\u590d\u5408\u4f53\u5728\u590d\u5236\u8870\u8001\u8fc7\u7a0b\u4e2d\u805a\u96c6\u5728\u6b63\u5e38\u548c\u65e9\u8870\u7ec6\u80de\u7684\u7578\u5f62\u6838\u4e2d\u3002
<\/a>R\u00f6hrl JM\u3001Arnold R\u3001Djabali K. Cells\u30022021 \u5e74 1 \u6708 14 \u65e5\uff1b10(1):153\u3002doi\uff1a10.3390\/cells10010153\u3002PMID\uff1a33466669\uff1bPMCID\uff1aPMC7828780\u3002<\/p>\n

\u4f7f\u7528\u5df4\u745e\u66ff\u5c3c\u6291\u5236 JAK-STAT \u4fe1\u53f7\u4f20\u5bfc\u53ef\u51cf\u5c11\u65e9\u8870\u7ec6\u80de\u7684\u708e\u75c7\u5e76\u6539\u5584\u7ec6\u80de\u7a33\u6001<\/a>
\u5218 C\u3001\u963f\u8bfa\u5fb7 R\u3001\u6069\u91cc\u514b\u65af G\u3001\u8d3e\u5df4\u5229 K. \u5355\u5143\u683c<\/em> 2019\uff1b8(10):1276\u30022019 \u5e74 10 \u6708 18 \u65e5\u53d1\u5e03\u3002doi:10.3390\/cells8101276<\/p>\n

\u4f53\u7ec6\u80de\u7a81\u53d8\u5206\u6790\u786e\u5b9a\u4e86\u539f\u53d1\u6027\u771f\u76ae\u6210\u7ea4\u7ef4\u7ec6\u80de\u4f53\u5916\u8001\u5316\u8fc7\u7a0b\u4e2d\u7684\u9009\u62e9\u8ff9\u8c61<\/a>
Narisu N\u3001Rothwell R\u3001Vrta\u010dnik P \u7b49\u3002 \u8870\u8001\u7ec6\u80de<\/em> 2019\uff1b18(6):e13010\u3002 doi\uff1a10.1111\/acel.13010<\/p>\n

\u77ac\u65f6\u5f15\u5165\u4eba\u7c7b\u7aef\u7c92\u9176 mRNA \u53ef\u6539\u5584\u65e9\u8870\u7ec6\u80de\u7684\u7279\u5f81<\/a>
\u674eY\uff0c\u5468G\uff0cBruno IG\uff0c\u7b49\u3002 \u8870\u8001\u7ec6\u80de<\/em>\u3002 2019\uff1b18(4)\uff1ae12979\u3002 doi\uff1a10.1111\/acel.12979<\/p>\n

\u6cd5\u5462\u57fa\u5316\u7fa7\u57fa\u672b\u7aef\u5c42\u86cb\u767d\u80bd\u7684\u81ea\u566c\u53bb\u9664<\/a>
Lu X\uff0cDjabali K. \u5355\u5143\u683c<\/em> 2018;7(4):33\u30022018 \u5e74 4 \u6708 23 \u65e5\u53d1\u5e03\u3002doi:10.3390\/cells7040033<\/p>\n

\u9776\u5411\u78f7\u8102\u9176 A2 \u53d7\u4f53\u53ef\u6539\u5584\u8fc7\u65e9\u8870\u8001\u8868\u578b<\/a>
Griveau A\u3001Wiel C\u3001Le Calv\u00e9 B \u7b49\u3002 \u8870\u8001\u7ec6\u80de<\/em> 2018\uff1b17(6):e12835\u3002 doi\uff1a10.1111\/acel.12835<\/p>\n

\u7ec6\u80de\u5185\u5728\u5e72\u6270\u7d20\u6837\u53cd\u5e94\u5c06\u590d\u5236\u538b\u529b\u4e0e\u65e9\u8870\u7d20\u5f15\u8d77\u7684\u7ec6\u80de\u8870\u8001\u8054\u7cfb\u8d77\u6765\u3002
<\/a>Kreienkamp R\u3001Graziano S\u3001Coll-Bonfill N\u3001Bedia-Diaz G\u3001Cybulla E\u3001Vindigni A\u3001Dorsett D\u3001Kubben N\u3001Batista LFZ\u3001Gonzalo S\u3002\u00a0\u624b\u673a\u4ee3\u8868<\/em>. 2018\u5e742\u670820\u65e5;22(8):2006-2015.<\/p>\n

\u76ae\u80a4\u548c\u8840\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u65f6\u949f\u5e94\u7528\u4e8e\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u79bb\u4f53\u7814\u7a76<\/a>
Horvath S\u3001Oshima J\u3001Martin GM \u7b49\u4eba\u3002 \u8001\u5316<\/em> \uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09\u3002 2018\uff1b10(7):1758-1775\u3002 doi\uff1a10.18632\/aging.101508<\/p>\n

\u6838\u8d28\u5c42\u86cb\u767d\u51b3\u5b9a\u4e86\u5c42\u86cb\u767d\u76f8\u5173\u591a\u80bd 2\u03b1 \u5728\u65e9\u8870\u7ec6\u80de\u4e2d\u7684\u751f\u957f\u8c03\u8282\u529f\u80fd\u3002<\/a>\u00a0Vidak S\u3001Georgiou K\u3001Fichtinger P\u3001Naetar N\u3001Dechat T\u3001Foisner R. J \u7ec6\u80de\u79d1\u5b66\u3002 2017 \u5e74 12 \u6708 28 \u65e5\u3002pii\uff1ajcs.208462\u3002 doi\uff1a10.1242\/jcs.208462\u3002 [\u5370\u5237\u524d\u7684\u7535\u5b50\u7248]<\/p>\n

\u95f4\u6b47\u6027\u4f7f\u7528\u6cd5\u5462\u57fa\u8f6c\u79fb\u9176\u6291\u5236\u5242\u548c\u841d\u535c\u786b\u7d20\u6cbb\u7597\u53ef\u6539\u5584\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u7ec6\u80de\u7a33\u6001\u3002\u00a0<\/a>\u52a0\u5e03\u91cc\u57c3\u5c14 D\u3001\u6c99\u5f17\u91cc DD\u3001\u6208\u767b LB\u3001\u8d3e\u5df4\u5229 K.\u00a0\u80bf\u7624\u9776\u70b9<\/em>\u3002 2017\u5e747\u670818\u65e5\uff1b8(39):64809-64826\u3002 doi\uff1a10.18632\/oncotarget.19363\u3002\u7535\u5b50\u6536\u85cf 2017 \u5e74 9 \u6708 12 \u65e5\u3002<\/p>\n

\u66ff\u7f57\u83ab\u53f8\u90e8\u5206\u633d\u6551\u4e86\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u7ec6\u80de\u8868\u578b\u3002<\/a>
\u52a0\u5e03\u91cc\u57c3\u5c14\u00b7D\u3001\u6208\u767b\u00b7LB\u3001\u8d3e\u5df4\u5229\u00b7K. PLoS\u7efc\u5408<\/em> 2016\uff1b11\uff0812\uff09\uff1ae0168988\u30022016 \u5e74 12 \u6708 29 \u65e5\u53d1\u5e03\u3002doi\uff1a10.1371\/journal.pone.0168988<\/p>\n

\u65e9\u8870\u86cb\u767d\u901a\u8fc7\u6d88\u8017\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u4e2d\u671f\u52a8\u7c92\u7ec6\u80de\u4e2d\u7684 CENP-F \u6765\u635f\u5bb3\u67d3\u8272\u4f53\u7684\u7ef4\u6301 <\/a>
\u827e\u65bd V\u3001\u5362 X\u3001\u52a0\u5e03\u91cc\u57c3\u5c14 D\u3001\u8d3e\u5df4\u5229 K. \u80bf\u7624\u9776\u70b9<\/em> 2016;7(17):24700-24718\u3002 doi:10.18632\/oncotarget.8267<\/p>\n

\u91cd\u65b0\u7f16\u7a0b\u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u53ef\u91cd\u5efa\u6b63\u5e38\u7684\u8868\u89c2\u9057\u4f20\u666f\u89c2\u3002<\/a>\u00a0Chen Z, Chang WY, Etheridge A, Strickfaden H, Jin Z, Palidwor G, Cho JH, Wang K, Kwon SY, Dor\u00e9 C, Raymond A, Hotta A, Ellis J, Kandel RA, Dilworth FJ, Perkins TJ, Hendzel MJ \uff0cGalas DJ\uff0c\u65af\u5766\u798f WL\u3002 \u3002\u8870\u8001\u7ec6\u80de<\/i>. 2017 \u5e74 6 \u6708 8 \u65e5. [\u7535\u5b50\u7248\u5148\u884c\u5370\u5237]\u4e0e\u65e9\u8870\u75c7\u76f8\u5173\u7684\u5c42\u86cb\u767d A \u7a81\u53d8\u4f53\u7684\u6c38\u4e45\u6027\u6cd5\u5462\u57fa\u5316\u4f1a\u635f\u5bb3\u5176\u5728\u95f4\u671f\u4e1d\u6c28\u9178 22 \u5904\u7684\u78f7\u9178\u5316\u3002<\/a>\u00a0Moiseeva O\u3001Lopes-Paciencia S\u3001Huot G\u3001Lessard F\u3001Ferbeyre G.\u00a0\u8001\u5316<\/i>\u00a0. 2016\u5e742\u6708;8(2):366-81.<\/p>\n

\u4e0e\u65e9\u8870\u75c7\u76f8\u5173\u7684\u5c42\u86cb\u767d A \u7a81\u53d8\u4f53\u7684\u6c38\u4e45\u6027\u6cd5\u5462\u57fa\u5316\u4f1a\u635f\u5bb3\u5176\u5728<\/a> \u95f4\u671f\u4e1d\u6c28\u9178 22\u3002<\/a>
Moiseeva O\u3001Lopes-Paciencia S\u3001Huot G\u3001Lessard F\u3001Ferbeyre G. \u8001\u5316<\/em> 2016\u5e742\u6708;8(2):366-81\u3002<\/p>\n

\u7ef4\u751f\u7d20 D \u53d7\u4f53\u4fe1\u53f7\u6539\u5584\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7ec6\u80de\u8868\u578b<\/a>
Kreienkamp R\u3001Croke M\u3001Neumann MA \u7b49\u3002 \u80bf\u7624\u9776\u70b9<\/em> 2016;7(21):30018-30031\u3002 doi:10.18632\/oncotarget.9065<\/p>\n

\u5c42\u86cb\u767d A \u662f\u4e00\u79cd\u5185\u6e90\u6027 SIRT6 \u6fc0\u6d3b\u5242\uff0c\u53ef\u4fc3\u8fdb SIRT6 \u4ecb\u5bfc\u7684 DNA \u4fee\u590d\u3002<\/a>\u00a0Ghosh S\u3001\u5218 B\u3001\u738b Y\u3001\u90dd Q\u3001\u5468 Z\u3002\u00a0\u624b\u673a\u4ee3\u8868<\/i>. 2015 \u5e74 11 \u6708 17 \u65e5;13(7):1396-1406. doi: 10.1016\/j.celrep.2015.10.006. Epub 2015 \u5e74 11 \u6708 5 \u65e5. PMID:26549451<\/p>\n

\u5c42\u76f8\u5173\u591a\u80bd 2\u03b1 (LAP2\u03b1) \u901a\u8fc7\u8868\u8fbe\u7ec6\u80de\u5916\u57fa\u8d28\u86cb\u767d\u6765\u589e\u5f3a\u65e9\u8870\u7ec6\u80de\u7684\u589e\u6b96\u3002
<\/a>\u7ef4\u8fbe\u514b S\u3001\u5e93\u672c N\u3001\u5fb7\u590f\u7279 T\u3001\u798f\u4f0a\u65af\u7eb3 R\u3002\u00a0\u57fa\u56e0\u4e0e\u53d1\u5c55\u3002<\/i>\u00a02015\u5e7410\u67081\u65e5;29(19):2022-36\u3002<\/p>\n

\u841d\u535c\u786b\u7d20\u53ef\u589e\u5f3a\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u7684\u65e9\u8870\u86cb\u767d\u6e05\u9664\u7387\u3002
<\/a>\u52a0\u5e03\u91cc\u57c3\u5c14\u00b7D\u3001\u7f57\u5fb7\u5c14\u00b7D\u3001\u6208\u767b\u00b7LB\u3001\u8d3e\u5df4\u5229\u00b7K.\u00a0\u8870\u8001\u7ec6\u80de<\/i>. 2014\u5e7412\u670816\u65e5\uff1a1-14\u3002<\/p>\n

\u6d88\u8017\u7532\u57fa\u8f6c\u79fb\u9176 Suv39h1 \u53ef\u6539\u5584 DNA \u4fee\u590d\u5e76\u5ef6\u957f\u65e9\u8870\u75c7\u5c0f\u9f20\u6a21\u578b\u7684\u5bff\u547d\u3002
<\/a>\u5218 B\uff0c\u738b Z\uff0c\u5f20 L\uff0cGhosh S\uff0c\u90d1 H\uff0c\u5468 Z\u3002\u56fd\u5bb6\u901a\u8baf\u793e<\/i>. 2013;4:1868.<\/p>\n

\u60a3\u6709\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u60a3\u8005\u7684\u5e7c\u7a1a\u6210\u4f53\u5e72\u7ec6\u80de\u5728\u4f53\u5185\u8868\u8fbe\u4f4e\u6c34\u5e73\u7684\u65e9\u8870\u86cb\u767d\u3002
<\/a>Wenzel V\u3001Roedl D\u3001Gabriel D\u3001Gordon LB\u3001Herlyn M\u3001Schneider R\u3001Ring J\u3001Djabali K\u3002
\u751f\u7269\u5f00\u653e<\/em>\u3002 2012 \u5e74 6 \u6708 15 \u65e5\uff1b1(6):516-26\u3002\u7535\u5b50\u7248 2012 \u5e74 4 \u6708 16 \u65e5<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d MMP-3 \u7684\u5e74\u9f84\u4f9d\u8d56\u6027\u4e27\u5931\u3002
<\/a>Harten IA\u3001Zahr RS\u3001Lemire JM\u3001Machan JT\u3001Moses MA\u3001Doiron RJ\u3001Curatolo AS\u3001Rothman FG\u3001Wight TN\u3001Toole BP\u3001Gordon LB\u3002\u00a0\u8001\u5e74\u751f\u7269\u79d1\u5b66\u4e0e\u533b\u5b66\u6742\u5fd7<\/em>. 2011\u5e7411\u6708;66(11):1201-7.<\/p>\n

\u65e9\u8870\u86cb\u767d\u548c\u7aef\u7c92\u529f\u80fd\u969c\u788d\u5171\u540c\u5f15\u53d1\u6b63\u5e38\u4eba\u7c7b\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u7ec6\u80de\u8870\u8001\u3002<\/a>
\u66f9 K\u3001\u5e03\u83b1\u5c14 CD\u3001\u6cd5\u8fbe DA\u3001Kieckhaefer JE\u3001\u5965\u5229\u5f17 M\u3001\u9102\u5c14\u591a\u65af MR\u3001\u7eb3\u8d1d\u5c14 EG\u3001\u67ef\u6797\u65af FS\u3002\u00a0J Clin Invest\u3002<\/em>\u00a02011\u5e747\u67081\u65e5;121(7):2833-44<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u7684\u5c42\u86cb\u767d A-Rb \u4fe1\u53f7\u4f20\u5bfc\u7f3a\u9677\u53ca\u901a\u8fc7\u6cd5\u5462\u57fa\u8f6c\u79fb\u9176\u6291\u5236\u800c\u9006\u8f6c\u3002<\/a>
Marji J\u3001O'Donoghue SI\u3001Mcclintock D\u3001Satagopam VP\u3001Schneider R\u3001Ratner D\u3001Worman HJ\u3001Gordon LB\u3001Djabali K.\u00a0PLoS\u7efc\u5408<\/em>. 2010\u5e746\u670815\u65e5;5(6):e11132.<\/p>\n

\u65e9\u8870\u86cb\u767d\u5bf9\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u60a3\u8005\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u6c27\u5316\u86cb\u767d\u79ef\u7d2f\u7684\u5f71\u54cd\u3002<\/a>
\u7ef4\u7279\u91cc G\u3001\u949f YW\u3001\u65af\u5854\u7279\u66fc ER\u3002\u00a0\u673a\u68b0\u8001\u5316\u5f00\u53d1<\/em>. 2010\u5e741\u6708;131(1):2-8.<\/p>\n

\u7531\u4e8e NURD \u590d\u5408\u7269\u7684\u4e22\u5931\uff0c\u4e0e\u8870\u8001\u76f8\u5173\u7684\u67d3\u8272\u8d28\u7f3a\u9677\u3002<\/a>
Pegoraro G\u3001Kubben N\u3001Wickert U\u3001G\u00f6hler H\u3001Hoffmann K\u3001Misteli T\u3002\u00a0\u5929\u7136\u7ec6\u80de\u751f\u7269\u5b66\u3002<\/em>\u00a02009\u5e7410\u6708;11(10):1261-7\u3002<\/p>\n

\u4e0e\u52a0\u901f\u8870\u8001\u76f8\u5173\u7684\u6210\u4f53\u5e72\u7ec6\u80de\u7684\u5c42\u86cb\u767d A \u4f9d\u8d56\u6027\u5931\u8c03\u3002<\/a>
Scaffidi P\uff0cMisteli T.\u00a0\u5929\u7136\u7ec6\u80de\u751f\u7269\u5b66\u3002\u00a0<\/em>2008\u5e744\u6708;10(4):452-9.<\/p>\n

\u91ce\u751f\u578b\u5c42\u86cb\u767d A \u4ee3\u8c22\u7684\u7d0a\u4e71\u4f1a\u5bfc\u81f4\u65e9\u8870\u8868\u578b\u3002<\/a>
\u574e\u5fb7\u62c9\u91cc\u5965\u00b7J\u3001\u82cf\u8fbe\u5361\u5c14\u00b7S\u3001\u7eb3\u74e6\u7f57\u00b7S\u3001\u96f7\u8fea\u00b7S\u3001\u79d1\u8fc8\u00b7L.\u00a0\u8870\u8001\u7ec6\u80de<\/em>. 2008\u5e746\u6708;7(3):355-67<\/p>\n

\u5df2\u77e5\u4f1a\u52a0\u901f\u4eba\u7c7b\u8870\u8001\u7684\u7a81\u53d8\u5c42\u86cb\u767d A \u4f1a\u5f15\u8d77\u6709\u4e1d\u5206\u88c2\u548c\u7ec6\u80de\u5468\u671f\u8fdb\u7a0b\u7684\u6539\u53d8\u3002<\/a>
Dechat T\u3001Shimi T\u3001Adam SA\u3001Rusinol AE\u3001Andres DA\u3001Spielmann HP\u3001Sinensky MS\u3001Goldman RD\u3002\u00a0\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a<\/em>. 2007\u5e743\u670820\u65e5;104(12):4955-60.<\/p>\n

\u5bfc\u81f4\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u7684\u5c42\u86cb\u767d A \u7a81\u53d8\u5f62\u5f0f\u662f\u4eba\u7c7b\u76ae\u80a4\u7ec6\u80de\u8870\u8001\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002<\/a>
\u9ea6\u514b\u6797\u6258\u514b D\u3001\u62c9\u7279\u7eb3 D\u3001\u6d1b\u5e93\u683c M\u3001\u6b27\u6587\u65af DM\u3001\u6208\u767b LB\u3001\u67ef\u6797\u65af FS\u3001\u8d3e\u5df4\u5229 K.\u00a0PLoS\u7efc\u5408<\/em>. 2007 \u5e74 12 \u6708 5 \u65e5;2(12):e1269\u3002<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u8fc7\u5ea6\u8868\u8fbe\u7684\u5c42\u86cb\u767d A \u86cb\u767d\u5f02\u6784\u4f53\u4f1a\u5e72\u6270\u65e9\u8870\u75c7\u548c\u6b63\u5e38\u7ec6\u80de\u7684\u6709\u4e1d\u5206\u88c2\u3002<\/a>
\u66f9K\uff0c\u5361\u4f69\u5c14BC\uff0c\u9102\u5c14\u591a\u65afMR\uff0c\u8d3e\u5df4\u5229K\uff0c\u67ef\u6797\u65afFS\u3002\u00a0\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a<\/em>. 2007\u5e743\u670820\u65e5;104(12):4949-54.<\/p>\n

\u901a\u8fc7\u6297\u5c42\u86cb\u767d A G608G \u6297\u4f53\u68c0\u6d4b\uff0c\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u7a81\u53d8\u5c42\u86cb\u767d A \u4e3b\u8981\u9488\u5bf9\u4eba\u7c7b\u8840\u7ba1\u7ec6\u80de\u3002<\/a>
\u9ea6\u514b\u6797\u6258\u514b D\u3001\u6208\u767b LB\u3001\u8d3e\u5df4\u5229 K.\u00a0\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a\u3002<\/em>\u00a02006 \u5e74 2 \u6708 14 \u65e5\uff1b103(7):2154-9\u3002<\/p>\n

\u5728\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u771f\u76ae\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\uff0c\u805a\u96c6\u86cb\u767d\u805a\u7cd6\u7684\u8868\u8fbe\u663e\u8457\u4e14\u5f02\u5e38\u4e0a\u8c03\u3002<\/a>
Lemire JM\u3001Patis C\u3001Gordon LB\u3001Sandy JD\u3001Toole BP\u3001Weiss AS\u3002\u00a0\u673a\u68b0\u8001\u5316\u5f00\u53d1\u3002<\/em>\u00a02006\u5e748\u6708;127(8):660-9\u3002<\/p>\n

\u901a\u8fc7\u836f\u7269\u6cbb\u7597\u633d\u6551\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u4e2d\u7684\u5f02\u67d3\u8272\u8d28\u7ec4\u7ec7\u3002<\/a>
Columbaro M\u3001Capanni C\u3001Mattioli E\u3001Novelli G\u3001Parnaik VK\u3001Squarzoni S\u3001Maraldi NM\u3001Lattanzi G\u3002\u00a0\u7ec6\u80de\u5206\u5b50\u751f\u547d\u79d1\u5b66\u3002<\/em>\u00a02005\u5e7411\u6708;62(22):2669-78\u3002<\/p>\n

\u57fa\u4e8e\u5c42\u86cb\u767d\u75c5\u7684\u8fc7\u65e9\u8870\u8001\u4e2d\u7684\u57fa\u56e0\u7ec4\u4e0d\u7a33\u5b9a\u6027\u3002<\/a>
\u5218 B\u3001\u738b J\u3001\u9648 KM\u3001Tjia WM\u3001\u9093 W\u3001\u5173 X\u3001\u9ec4 JD\u3001\u674e KM\u3001\u5468 PY\u3001\u9648 DJ\u3001\u88f4 D\u3001Pendas AM\u3001Cadi\u00f1anos J\u3001L\u00f3pez-Ot\u00edn C\u3001Tse HF\u3001Hutchison C\u3001\u9648\u6770\uff0c\u66f9Y\uff0cCheah KS\uff0cTryggvason K\uff0c\u5468Z\u3002\u00a0\u5929\u7136\u533b\u5b66\u3002<\/em>\u00a02005\u5e747\u6708;11(7):780-5\u3002<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u4e2d\u7a81\u53d8\u5c42\u86cb\u767d A \u7684\u52a0\u5de5\u4e0d\u5b8c\u5168\u4f1a\u5bfc\u81f4\u6838\u5f02\u5e38\uff0c\u800c\u6cd5\u5462\u57fa\u8f6c\u79fb\u9176\u6291\u5236\u53ef\u4ee5\u9006\u8f6c\u8fd9\u79cd\u5f02\u5e38\u3002<\/a>
Glynn MW\uff0cGlover TW\u3002\u00a0\u4eba\u7c7b\u5206\u5b50\u9057\u4f20\u5b66\u3002\u00a0<\/em>2005\u5e7410\u670815\u65e5;14(20):2959-69\u3002<\/p>\n

\u7a81\u53d8\u5c42\u86cb\u767d A \u7684\u79ef\u7d2f\u5bfc\u81f4\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u7684\u6838\u7ed3\u6784\u53d1\u751f\u9010\u6e10\u53d8\u5316\u3002<\/a>
Goldman RD\u3001Shumaker DK\u3001Erdos MR\u3001Eriksson M\u3001Goldman AE\u3001Gordon LB\u3001Gruenbaum Y\u3001Khuon S\u3001Mendez M\u3001Varga R\u3001Collins FS\u3002\u00a0\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a<\/em>.<\/em><\/a>\u00a02004 \u5e74 6 \u6708 15 \u65e5\uff1b101(24):8963-8\u3002<\/p>\n

\u5c42\u86cb\u767d A \u4e2d\u53cd\u590d\u53d1\u751f\u7684\u65b0\u751f\u70b9\u7a81\u53d8\u5bfc\u81f4\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u3002<\/a>
Eriksson M\u3001Brown WT\u3001Gordon LB\u3001Glynn MW\u3001Singer J\u3001Scott L\u3001Erdos MR\u3001Robbins CM\u3001Moses TY\u3001Berglund P\u3001Dutra A\u3001Pak E\u3001Durkin S\u3001Csoka AB\u3001Boehnke M\u3001Glover TW\u3001Collins FS\u3002\u00a0\u81ea\u7136\u3002<\/em>\u00a02003\u5e745\u670815\u65e5;423(6937):293-8\u3002<\/p>\n

[\/et_pb_text][et_pb_text]admin_label=\u201dPSADFN004\u2033 module_id=\u201dPSADFN004\u2033 _builder_version=\u201d4.16\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

\u5e15\u8428\u5fb7\u592b\u7eb3 004<\/strong><\/h4>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u4e2d\u7a81\u53d8\u5c42\u86cb\u767d A \u7684\u52a0\u5de5\u4e0d\u5b8c\u5168\u4f1a\u5bfc\u81f4\u6838\u5f02\u5e38\uff0c\u800c\u6cd5\u5462\u57fa\u8f6c\u79fb\u9176\u6291\u5236\u53ef\u4ee5\u9006\u8f6c\u8fd9\u79cd\u5f02\u5e38\u3002<\/a>
Glynn MW\uff0cGlover TW\u3002\u00a0\u4eba\u7c7b\u5206\u5b50\u9057\u4f20\u5b66\u3002\u00a0<\/em>2005\u5e7410\u670815\u65e5;14(20):2959-69\u3002<\/p>\n

[\/et_pb_text][et_pb_text]admin_label=\u201dHGADFN005\u2033 module_id=\u201dHGADFN005\u2033 _builder_version=\u201d4.16\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

HGADFN005<\/strong>\u00a0<\/strong><\/h4>\n

\u5c42\u86cb\u767d A \u4e2d\u53cd\u590d\u53d1\u751f\u7684\u65b0\u751f\u70b9\u7a81\u53d8\u5bfc\u81f4\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u3002<\/a>
Eriksson M\u3001Brown WT\u3001Gordon LB\u3001Glynn MW\u3001Singer J\u3001Scott L\u3001Erdos MR\u3001Robbins CM\u3001Moses TY\u3001Berglund P\u3001Dutra A\u3001Pak E\u3001Durkin S\u3001Csoka AB\u3001Boehnke M\u3001Glover TW\u3001Collins FS\u3002\u00a0\u81ea\u7136\u3002<\/em>\u00a02003\u5e745\u670815\u65e5;423(6937):293-8\u3002<\/p>\n

[\/et_pb_text][et_pb_textadmin_label=\u201dHGADFN008\u2033module_id=\u201dHGADFN008\u2033_builder_version=\u201d4.16\u2033custom_margin=\u201d50px||50px||true\u201dz_index_tablet=\u201d500\u2033global_colors_info=\u201d{}\u201d]<\/p>\n

HGADFN008<\/strong>\u00a0<\/strong><\/h4>\n

\u5c42\u86cb\u767d A \u4e2d\u53cd\u590d\u53d1\u751f\u7684\u65b0\u751f\u70b9\u7a81\u53d8\u5bfc\u81f4\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u3002<\/a>
Eriksson M\u3001Brown WT\u3001Gordon LB\u3001Glynn MW\u3001Singer J\u3001Scott L\u3001Erdos MR\u3001Robbins CM\u3001Moses TY\u3001Berglund P\u3001Dutra A\u3001Pak E\u3001Durkin S\u3001Csoka AB\u3001Boehnke M\u3001Glover TW\u3001Collins FS\u3002\u00a0\u81ea\u7136\u3002<\/em>\u00a02003\u5e745\u670815\u65e5;423(6937):293-8\u3002<\/p>\n

[\/et_pb_text][et_pb_text]admin_label=\u201dHGADFN014\u2033 module_id=\u201dHGADFN014\u2033 _builder_version=\u201d4.16\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

HGADFN014<\/strong>\u00a0<\/strong><\/h4>\n

\u5c42\u86cb\u767d A \u4e2d\u53cd\u590d\u53d1\u751f\u7684\u65b0\u751f\u70b9\u7a81\u53d8\u5bfc\u81f4\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u3002<\/a>
Eriksson M\u3001Brown WT\u3001Gordon LB\u3001Glynn MW\u3001Singer J\u3001Scott L\u3001Erdos MR\u3001Robbins CM\u3001Moses TY\u3001Berglund P\u3001Dutra A\u3001Pak E\u3001Durkin S\u3001Csoka AB\u3001Boehnke M\u3001Glover TW\u3001Collins FS\u3002\u00a0\u81ea\u7136\u3002<\/em>\u00a02003\u5e745\u670815\u65e5;423(6937):293-8\u3002<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGMDFN090″ module_id=”HGMDFN090″ _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGMDFN090<\/strong><\/h4>\n

\u5728\u65b0\u578b\u7ec6\u80de\u6a21\u578b\u4e2d\u7b5b\u9009\u7279\u5f02\u6027\u5f3a\u3001\u9ad8\u6548\u7684siRNA\u7528\u4e8e\u6cbb\u7597Hutchinson-Gilford\u65e9\u8870\u7efc\u5408\u5f81<\/a>
Dzianisava V\u3001Piekarowicz K\u3001Machowska M\u3001Rzepecki R. \u5206\u5b50\u6cbb\u7597\u6838\u9178<\/em>. 2025;36(4):102727\u3002\u53d1\u8868\u4e8e2025\u5e7410\u67083\u65e5\u3002doi:10.1016\/j.omtn.2025.102727<\/p>\n

\u5bf9 Hutchinson-Gilford \u65e9\u8870\u75c7\u60a3\u8005\u7684\u8f6c\u5f55\u7ec4\u5206\u6790\u63ed\u793a\u4e86\u65e9\u8870\u86cb\u767d\u7684\u4e3b\u8981\u9776\u901a\u8def<\/a>
Vidak S\u3001Kim S\u3001Misteli T. \u9884\u5370\u672c\u3002\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125\u3002\u53d1\u8868\u4e8e2025\u5e749\u670820\u65e5\u3002doi:10.1101\/2025.09.18.677125<\/p>\n

\u901a\u8fc7\u5185\u6838\u819c\u86cb\u767d SUN2 \u6fc0\u6d3b\u5185\u8d28\u7f51\u5e94\u6fc0\u5bfc\u81f4\u8fc7\u65e9\u8870\u8001<\/a>
Vidak S\u3001Serebryannyy LA\u3001Pegoraro G\u3001Misteli T.\u00a0\u624b\u673a\u4ee3\u8868<\/em>\u3002 2023\uff1b42(5)\uff1a112534\u3002 doi:10.1016\/j.celrep.2023.112534<\/p>\n

\u72ec\u7279\u7684\u65e9\u8870\u86cb\u767d C \u7aef\u80bd\u901a\u8fc7\u62ef\u6551 BUBR1 \u6539\u5584\u4e86\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u8868\u578b\u3002<\/a>
Zhang N, Hu Q, Sui T, Fu L, Zhang X, Wang Y, Zhu X, Huang B, Lu J, Li Z, Zhang Y. Nat Aging. 2023 \u5e74 2 \u6708;3(2):185-201\u3002doi: 10.1038\/s43587-023-00361-w\u30022023 \u5e74 2 \u6708 2 \u65e5\u7535\u5b50\u7248\u3002\u52d8\u8bef\u8868\uff0c\u8f7d\u4e8e\uff1aNat Aging\u30022023 \u5e74 5 \u6708 2 \u65e5\uff1bPMID\uff1a37118121\uff1bPMCID\uff1aPMC10154249\u3002<\/p>\n

\u901a\u8fc7\u8d28\u8c31\u6cd5\u5bf9\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u60a3\u8005\u7ec6\u80de\u4e2d\u7684\u6cd5\u5462\u57fa\u5316\u65e9\u8870\u86cb\u767d\u8fdb\u884c\u5b9a\u91cf\u5206\u6790<\/a>
Camafeita E\u3001Jorge I\u3001Rivera-Torres J\u3001Andr\u00e9s V\u3001V\u00e1zquez J\u3002 Int J Mol Sci\u3002 2022\uff1b23(19):11733\u3002\u53d1\u5e03\u4e8e 2022 \u5e74 10 \u6708 3 \u65e5\u3002doi:10.3390\/ijms231911733<\/p>\n

\u7aef\u7c92\u9176\u7597\u6cd5\u53ef\u9006\u8f6c\u65e9\u8870\u5c0f\u9f20\u7684\u8840\u7ba1\u8870\u8001\u5e76\u5ef6\u957f\u5176\u5bff\u547d<\/a>
Mojiri A\u3001Walther BK\u3001Jiang C \u7b49\u4eba\u3002[2021 \u5e74 8 \u6708 14 \u65e5\u63d0\u524d\u5728\u7ebf\u53d1\u8868]\u3002\u00a0\u6b27\u6d32\u5fc3\u810f\u6742\u5fd7<\/em>. 2021\uff1behab547.doi:10.1093\/eurheartj\/ehab547<\/p>\n

\u901a\u8fc7\u76f8\u5206\u79bb\u5b9e\u73b0\u591a\u7ec4\u5206\u7ebf\u7c92\u4f53\u6838\u82f7\u7684\u81ea\u7ec4\u88c5\u3002
<\/a>Feric M\u3001Demarest TG\u3001Tian J\u3001Croteau DL\u3001Bohr VA\u3001Misteli T\u3002EMBO J\u30022021 \u5e74 3 \u6708 15 \u65e5\uff1b40(6):e107165\u3002doi: 10.15252\/embj.2020107165\u3002\u7535\u5b50\u7248 2021 \u5e74 2 \u6708 23 \u65e5\u3002PMID\uff1a33619770\uff1bPMCID\uff1aPMC7957436\u3002<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u5c42\u76f8\u5173\u57df\u7684\u8868\u89c2\u9057\u4f20\u5931\u8c03<\/a>
K\u00f6hler F\u3001Bormann F\u3001Raddatz G \u7b49\u4eba\u3002 \u57fa\u56e0\u7ec4\u533b\u5b66<\/em> 2020;12(1):46\u30022020 \u5e74 5 \u6708 25 \u65e5\u53d1\u5e03\u3002doi:10.1186\/s13073-020-00749-y<\/p>\n

\u67d3\u8272\u8d28\u548c\u7ec6\u80de\u9aa8\u67b6\u675f\u7f1a\u51b3\u5b9a\u8868\u8fbe\u65e9\u8001\u86cb\u767d\u7684\u7ec6\u80de\u7684\u6838\u5f62\u6001<\/a>
Lionetti MC\u3001Bonfanti S\u3001Fumagalli MR\u3001Budrikis Z\u3001Font-Clos F\u3001Costantini G\u3001Chepizhko O\u3001Zapperi S\u3001La Porta CAM\u3002 \u751f\u7269\u7269\u7406\u6742\u5fd7<\/em> 2020\u5e745\u67085\u65e5;118(9):2319-2332\u3002<\/p>\n

\u77ac\u65f6\u5f15\u5165\u4eba\u7c7b\u7aef\u7c92\u9176 mRNA \u53ef\u6539\u5584\u65e9\u8870\u7ec6\u80de\u7684\u7279\u5f81<\/a>
\u674eY\uff0c\u5468G\uff0cBruno IG\uff0c\u7b49\u3002 \u8870\u8001\u7ec6\u80de<\/em> 2019\uff1b18(4):e12979\u3002 doi\uff1a10.1111\/acel.12979<\/p>\n

\u7ec6\u80de\u5185\u5728\u5e72\u6270\u7d20\u6837\u53cd\u5e94\u5c06\u590d\u5236\u538b\u529b\u4e0e\u65e9\u8870\u7d20\u5f15\u8d77\u7684\u7ec6\u80de\u8870\u8001\u8054\u7cfb\u8d77\u6765\u3002
<\/a>Kreienkamp R\u3001Graziano S\u3001Coll-Bonfill N\u3001Bedia-Diaz G\u3001Cybulla E\u3001Vindigni A\u3001Dorsett D\u3001Kubben N\u3001Batista LFZ\u3001Gonzalo S\u3002\u00a0\u624b\u673a\u4ee3\u8868<\/em>. 2018\u5e742\u670820\u65e5;22(8):2006-2015.<\/p>\n

\u76ae\u80a4\u548c\u8840\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u65f6\u949f\u5e94\u7528\u4e8e\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u79bb\u4f53\u7814\u7a76<\/a>
Horvath S\u3001Oshima J\u3001Martin GM \u7b49\u4eba\u3002 \u8001\u5316<\/em> \uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09\u3002 2018\uff1b10(7):1758-1775\u3002 doi\uff1a10.18632\/aging.101508<\/p>\n

\u6838\u8d28\u5c42\u86cb\u767d\u51b3\u5b9a\u4e86\u5c42\u86cb\u767d\u76f8\u5173\u591a\u80bd 2\u03b1 \u5728\u65e9\u8870\u7ec6\u80de\u4e2d\u7684\u751f\u957f\u8c03\u8282\u529f\u80fd\u3002<\/a>\u00a0Vidak S\u3001Georgiou K\u3001Fichtinger P\u3001Naetar N\u3001Dechat T\u3001Foisner R. J \u7ec6\u80de\u79d1\u5b66\u3002 2017 \u5e74 12 \u6708 28 \u65e5\u3002pii\uff1ajcs.208462\u3002 doi\uff1a10.1242\/jcs.208462\u3002 [\u5370\u5237\u524d\u7684\u7535\u5b50\u7248]<\/p>\n

\u65e9\u8001\u86cb\u767d\u5bf9 PCNA \u7684\u9694\u79bb\u4fc3\u8fdb\u4e86\u5c42\u86cb\u767d\u75c5\u76f8\u5173\u65e9\u8001\u7efc\u5408\u5f81\u4e2d\u590d\u5236\u53c9\u7684\u5d29\u6e83\u548c XPA \u7684\u9519\u8bef\u5b9a\u4f4d<\/a>
Hilton BA\u3001Liu J\u3001Cartwright BM \u7b49\u4eba\u3002 \u7f8e\u56fd\u5b9e\u9a8c\u751f\u7269\u5b66\u5b66\u4f1a\u8054\u5408\u4f1a<\/em> 2017;31(9):3882-3893.doi:10.1096\/fj.201700014R<\/p>\n

\u7ef4\u751f\u7d20 D \u53d7\u4f53\u4fe1\u53f7\u6539\u5584\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7ec6\u80de\u8868\u578b<\/a>
Kreienkamp R\u3001Croke M\u3001Neumann MA \u7b49\u3002 \u80bf\u7624\u9776\u70b9<\/em> 2016;7(21):30018-30031\u3002 doi:10.18632\/oncotarget.9065<\/p>\n

\u91cd\u65b0\u7f16\u7a0b\u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u53ef\u91cd\u5efa\u6b63\u5e38\u7684\u8868\u89c2\u9057\u4f20\u666f\u89c2\u3002\u00a0<\/a>Chen Z, Chang WY, Etheridge A, Strickfaden H, Jin Z, Palidwor G, Cho JH, Wang K, Kwon SY, Dor\u00e9 C, Raymond A, Hotta A, Ellis J, Kandel RA, Dilworth FJ, Perkins TJ, Hendzel MJ \uff0cGalas DJ\uff0c\u65af\u5766\u798f WL\u3002 \u3002\u8870\u8001\u7ec6\u80de<\/em>. 2017 \u5e74 6 \u6708 8 \u65e5. [\u7535\u5b50\u7248\u5148\u884c\u5370\u5237]<\/p>\n

\u4e9a\u7532\u84dd\u53ef\u51cf\u8f7b\u65e9\u8870\u75c7\u7684\u6838\u548c\u7ebf\u7c92\u4f53\u5f02\u5e38\u3002
<\/a>\u718aZM\uff0c\u5d14JY\uff0c\u738bK\uff0c\u5f20H\uff0cTariq Z\uff0c\u5434D\uff0cKo E\uff0cLaDana C\uff0cSesaki H\uff0c\u66f9K\u3002\u00a0\u8870\u8001\u7ec6\u80de\u3002<\/i><\/a>\u00a0 2015 \u5e74 12 \u6708 14 \u65e5\u3002[\u7535\u5b50\u7248\u5148\u884c\u5370\u5237]<\/p>\n

\u5c42\u76f8\u5173\u591a\u80bd 2\u03b1 (LAP2\u03b1) \u901a\u8fc7\u8868\u8fbe\u7ec6\u80de\u5916\u57fa\u8d28\u86cb\u767d\u6765\u589e\u5f3a\u65e9\u8870\u7ec6\u80de\u7684\u589e\u6b96\u3002
<\/a>\u7ef4\u8fbe\u514b S\u3001\u5e93\u672c N\u3001\u5fb7\u590f\u7279 T\u3001\u798f\u4f0a\u65af\u7eb3 R\u3002\u00a0\u57fa\u56e0\u4e0e\u53d1\u5c55\u3002<\/i>\u00a02015\u5e7410\u67081\u65e5;29(19):2022-36\u3002<\/p>\n

\u536b\u661f\u5f02\u67d3\u8272\u8d28\u7684\u9ad8\u9636\u5c55\u5f00\u662f\u7ec6\u80de\u8870\u8001\u8fc7\u7a0b\u4e2d\u6301\u7eed\u4e14\u65e9\u671f\u7684\u4e8b\u4ef6\u3002
<\/a>\u65af\u65fa\u68ee EC\u3001\u66fc\u5b81 B\u3001\u5f20 H\u3001\u52b3\u4f26\u65af JB\u3002\u00a0\u7ec6\u80de\u751f\u7269\u5b66\u6742\u5fd7<\/i>. 2013\u5e7412\u670823\u65e5;203(6):929-42<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u57fa\u56e0\u7ec4\u7ec4\u7ec7\u3001\u7ec4\u86cb\u767d\u7532\u57fa\u5316\u548c DNA-\u5c42\u86cb\u767d A\/C \u76f8\u4e92\u4f5c\u7528\u7684\u76f8\u5173\u6539\u53d8\u3002
<\/a>McCord RP\u3001Nazario-Toole A\u3001Zhang H\u3001Chines PS\u3001Zhan Y\u3001Erdos MR\u3001Collins FS\u3001Dekker J\u3001Cao K\u3002\u00a0\u57fa\u56e0\u7ec4<\/i>\u00a0\u89e3\u6790<\/i>. 2013 \u5e74 2 \u6708;23(2):260-9\u3002\u7535\u5b50\u7248 2012 \u5e74 11 \u6708 14 \u65e5\u3002<\/p>\n

\u901a\u8fc7 SNP \u9635\u5217\u548c\u914d\u5bf9\u6d4b\u5e8f\u6bd4\u8f83\u7ec4\u6210\u548c\u590d\u5236\u538b\u529b\u5f15\u8d77\u7684\u57fa\u56e0\u7ec4\u7ed3\u6784\u53d8\u5f02\u3002<\/a>
Arlt MF\u3001Ozdemir AC\u3001Birkeland SR\u3001Lyons RH Jr\u3001Glover TW\u3001Wilson TE\u3002\u00a0\u9057\u4f20\u5b66<\/em>. 2011\u5e743\u6708;187(3):675-83.<\/p>\n

\u7f9f\u57fa\u8132\u4f1a\u8bf1\u5bfc\u4eba\u7c7b\u7ec6\u80de\u4e2d\u65b0\u751f\u62f7\u8d1d\u6570\u53d8\u5f02\u3002<\/a>
Arlt MF\u3001Ozdemir AC\u3001Birkeland SR\u3001Wilson TE\u3001Glover TW\u3002\u00a0\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a\u3002<\/em>\u00a02011\u5e7410\u670818\u65e5;108(42):17360-5<\/p>\n

\u65e9\u8870\u86cb\u767d\u548c\u7aef\u7c92\u529f\u80fd\u969c\u788d\u5171\u540c\u5f15\u53d1\u6b63\u5e38\u4eba\u7c7b\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u7ec6\u80de\u8870\u8001\u3002<\/a>
\u66f9 K\u3001\u5e03\u83b1\u5c14 CD\u3001\u6cd5\u8fbe DA\u3001Kieckhaefer JE\u3001\u5965\u5229\u5f17 M\u3001\u9102\u5c14\u591a\u65af MR\u3001\u7eb3\u8d1d\u5c14 EG\u3001\u67ef\u6797\u65af FS\u3002\u00a0J Clin Invest\u3002<\/em>\u00a02011\u5e747\u67081\u65e5;121(7):2833-44<\/p>\n

CTP\uff1a\u78f7\u9178\u80c6\u78b1\u80de\u82f7\u9170\u8f6c\u79fb\u9176\u03b1\uff08CCT\u03b1\uff09\u548c\u5c42\u86cb\u767d\u6539\u53d8\u6838\u819c\u7ed3\u6784\u800c\u4e0d\u5f71\u54cd\u78f7\u8102\u9170\u80c6\u78b1\u7684\u5408\u6210\u3002<\/a>
Gehrig K\u3001Ridgway ND\u3002\u00a0\u751f\u7269\u5316\u5b66\u4e0e\u751f\u7269\u7269\u7406\u5b66\u62a5<\/em>. 2011\u5e746\u6708;1811(6):377-85.<\/p>\n

\u65e9\u8870\u86cb\u767d\u5bf9\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u60a3\u8005\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u6c27\u5316\u86cb\u767d\u79ef\u7d2f\u7684\u5f71\u54cd\u3002<\/a>
\u7ef4\u7279\u91cc G\u3001\u949f YW\u3001\u65af\u5854\u7279\u66fc ER\u3002\u00a0\u673a\u68b0\u8001\u5316\u5f00\u53d1<\/em>. 2010\u5e741\u6708;131(1):2-8.<\/p>\n

\u590d\u5236\u538b\u529b\u4f1a\u8bf1\u5bfc\u4eba\u7c7b\u7ec6\u80de\u4e2d\u5168\u57fa\u56e0\u7ec4\u62f7\u8d1d\u6570\u7684\u53d8\u5316\uff0c\u7c7b\u4f3c\u4e8e\u591a\u6001\u6027\u548c\u81f4\u75c5\u6027\u53d8\u5f02\u3002<\/a>
Arlt MF\u3001Mulle JG\u3001Schaibley VM\u3001Ragland RL\u3001Durkin SG\u3001Warren ST\u3001Glover TW\u3002\u00a0\u7f8e\u56fd\u4eba\u7c7b\u9057\u4f20\u5b66\u6742\u5fd7<\/em>. 2009\u5e743\u6708;84(3):339-50.<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u8fc7\u5ea6\u8868\u8fbe\u7684\u5c42\u86cb\u767d A \u86cb\u767d\u5f02\u6784\u4f53\u4f1a\u5e72\u6270\u65e9\u8870\u75c7\u548c\u6b63\u5e38\u7ec6\u80de\u7684\u6709\u4e1d\u5206\u88c2\u3002<\/a>
\u66f9K\uff0c\u5361\u4f69\u5c14BC\uff0c\u9102\u5c14\u591a\u65afMR\uff0c\u8d3e\u5df4\u5229K\uff0c\u67ef\u6797\u65afFS\u3002\u00a0\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a<\/em>. 2007\u5e743\u670820\u65e5;104(12):4949-54.<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u4e2d\u7a81\u53d8\u5c42\u86cb\u767d A \u7684\u52a0\u5de5\u4e0d\u5b8c\u5168\u4f1a\u5bfc\u81f4\u6838\u5f02\u5e38\uff0c\u800c\u6cd5\u5462\u57fa\u8f6c\u79fb\u9176\u6291\u5236\u53ef\u4ee5\u9006\u8f6c\u8fd9\u79cd\u5f02\u5e38\u3002<\/a>
Glynn MW\uff0cGlover TW\u3002\u00a0\u4eba\u7c7b\u5206\u5b50\u9057\u4f20\u5b66\u3002\u00a0<\/em>2005\u5e7410\u670815\u65e5;14(20):2959-69\u3002<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN122″ module_id=”HGADFN122″ _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN122<\/b><\/h4>\n

\u5bf9 Hutchinson-Gilford \u65e9\u8870\u75c7\u60a3\u8005\u7684\u8f6c\u5f55\u7ec4\u5206\u6790\u63ed\u793a\u4e86\u65e9\u8870\u86cb\u767d\u7684\u4e3b\u8981\u9776\u901a\u8def<\/a>
Vidak S\u3001Kim S\u3001Misteli T. \u9884\u5370\u672c\u3002\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125\u3002\u53d1\u8868\u4e8e2025\u5e749\u670820\u65e5\u3002doi:10.1101\/2025.09.18.677125<\/p>\n

\u4ea8\u5ef7\u987f\u6c0f\u75c5\u60a3\u8005\u539f\u53d1\u6027\u76ae\u80a4\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u5f02\u5e38\u8fc1\u79fb\u7279\u5f81\u6709\u53ef\u80fd\u5229\u7528\u57fa\u4e8e\u56fe\u50cf\u7684\u673a\u5668\u5b66\u4e60\u5de5\u5177\u63ed\u793a\u75be\u75c5\u8fdb\u5c55<\/a>
Gharaba S\u3001Shalem A\u3001Paz O\u3001Muchtar N\u3001Wolf L\u3001Weil M\u3002 \u8ba1\u7b97\u673a\u751f\u7269\u533b\u5b66<\/em>\u30022024 \u5e74 8 \u6708 2 \u65e5\u5728\u7ebf\u53d1\u8868\u3002doi:10.1016\/j.compbiomed.2024.108970<\/p>\n

\u6270\u52a8\u808c\u52a8\u86cb\u767d\u5e3d\u4f5c\u4e3a\u4ea8\u5ef7\u987f\u6c0f\u75c5\u60a3\u8005\u539f\u53d1\u6027\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u7684\u4e00\u79cd\u65b0\u7684\u4e2a\u6027\u5316\u751f\u7269\u6807\u5fd7\u7269<\/a>
Gharaba S\u3001Paz O\u3001Feld L\u3001Abashidze A\u3001Weinrab M\u3001Muchtar N\u3001Baransi A\u3001Shalem A\u3001Sprecher U\u3001Wolf L\u3001Wolfenson H\u3001Weil M\u3002\u524d\u7ec6\u80de\u5f00\u53d1\u751f\u7269\u5b66\u3002 2023 \u5e74 1 \u6708 18 \u65e5\uff1b11:1013721\u3002 DOI\uff1a10.3389\/fcell.2023.1013721\u3002\u7535\u8bdd\u53f7\u7801\uff1a36743412\uff1b PMCID\uff1aPMC9889876\u3002<\/p>\n

\u4eba\u7c7b\u5e73\u6ed1\u808c\u7ec6\u80de\u548c\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u7684\u76f4\u63a5\u91cd\u7f16\u7a0b\u63ed\u793a\u4e86\u4e0e\u8870\u8001\u548c\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u76f8\u5173\u7684\u7f3a\u9677<\/a>
Bersini S\u3001Schulte R\u3001Huang L\u3001Tsai H\u3001Hetzer MW\u3002 \u57c3\u5229\u592b<\/em>. 2020 \u5e74 9 \u6708 8 \u65e5\uff1b9\uff1ae54383\u3002doi\uff1a10.7554\/eLife.54383\u3002PMID\uff1a32896271\uff1bPMCID\uff1aPMC7478891\u3002<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u5c42\u76f8\u5173\u57df\u7684\u8868\u89c2\u9057\u4f20\u5931\u8c03<\/a>
K\u00f6hler F\u3001Bormann F\u3001Raddatz G \u7b49\u4eba\u3002 \u57fa\u56e0\u7ec4\u533b\u5b66<\/em>. 2020;12(1):46\u30022020 \u5e74 5 \u6708 25 \u65e5\u53d1\u5e03\u3002doi:10.1186\/s13073-020-00749-y<\/p>\n

PML2 \u4ecb\u5bfc\u7684\u7ebf\u72b6\u6838\u4f53\u6807\u5fd7\u7740\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u665a\u671f\u8870\u8001<\/a>
\u738b\u6885\uff0c\u738b\u73b2\uff0c\u94b1\u6885\u7b49\u3002[2020 \u5e74 4 \u6708 29 \u65e5\u5728\u7ebf\u53d1\u8868\uff0c\u63d0\u524d\u5370\u5237]\u3002 \u8870\u8001\u7ec6\u80de
<\/em>\u786e\u8ba4\u7ec6\u80de\u7cfb PRF \u7684\u66f4\u6b63\u6b63\u5728\u7b49\u5f85\u4e2d<\/strong><\/p>\n

\u77ac\u65f6\u5f15\u5165\u4eba\u7c7b\u7aef\u7c92\u9176 mRNA \u53ef\u6539\u5584\u65e9\u8870\u7ec6\u80de\u7684\u7279\u5f81<\/a>
\u674eY\uff0c\u5468G\uff0cBruno IG\uff0c\u7b49\u3002 \u8870\u8001\u7ec6\u80de<\/em> 2019\uff1b18(4):e12979\u3002 doi\uff1a10.1111\/acel.12979<\/p>\n

\u6839\u636e\u4eba\u7c7b\u771f\u76ae\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u8f6c\u5f55\u7ec4\u9884\u6d4b\u5e74\u9f84<\/a>
Fleischer JG\u3001Schulte R\u3001Tsai HH \u7b49\u4eba\u3002 \u57fa\u56e0\u7ec4\u751f\u7269\u5b66<\/em> 2018;19(1):221\u30022018 \u5e74 12 \u6708 20 \u65e5\u53d1\u5e03\u3002doi:10.1186\/s13059-018-1599-6<\/p>\n

\u76ae\u80a4\u548c\u8840\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u65f6\u949f\u5e94\u7528\u4e8e\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u79bb\u4f53\u7814\u7a76<\/a>
Horvath S\u3001Oshima J\u3001Martin GM \u7b49\u4eba\u3002 \u8001\u5316<\/em> \uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09\u3002 2018\uff1b10(7):1758-1775\u3002 doi\uff1a10.18632\/aging.101508<\/p>\n

\u4e8c\u7532\u53cc\u80cd\u53ef\u51cf\u8f7b\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u771f\u76ae\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u8870\u8001\u7ec6\u80de\u8868\u578b\u3002<\/a>\u00a0\u6734SK, \u7533OS\u3002\u00a0\u76ae\u80a4\u79d1\u4e13\u5bb6<\/i>. 2017 \u5e74 2 \u6708 13 \u65e5\u3002[\u7535\u5b50\u7248\u5148\u884c\u5370\u5237]\u5c42\u86cb\u767d A \u662f\u4e00\u79cd\u5185\u6e90\u6027 SIRT6 \u6fc0\u6d3b\u5242\uff0c\u53ef\u4fc3\u8fdb SIRT6 \u4ecb\u5bfc\u7684 DNA \u4fee\u590d\u3002<\/a>\u00a0Ghosh S\u3001\u5218 B\u3001\u738b Y\u3001\u90dd Q\u3001\u5468 Z\u3002\u00a0\u624b\u673a\u4ee3\u8868<\/i>. 2015 \u5e74 11 \u6708 17 \u65e5;13(7):1396-1406. doi: 10.1016\/j.celrep.2015.10.006. Epub 2015 \u5e74 11 \u6708 5 \u65e5. PMID:26549451<\/p>\n

\u6df1\u5165\u4e86\u89e3\u8870\u8001\u7ec6\u80de\u6a21\u578b\u4e2d\u6c34\u75d8\u5e26\u72b6\u75b1\u75b9\u75c5\u6bd2\u611f\u67d3\uff08\u5e26\u72b6\u75b1\u75b9\uff09\u671f\u95f4\u514d\u75ab\u8870\u8001\u7684\u4f5c\u7528\u3002
<\/a>Kim JA\u3001Park SK\u3001Kumar M\u3001Lee CH \u548c Shin OS\u3002\u00a0\u80bf\u7624\u9776\u70b9<\/i>. 2015 \u5e74 10 \u6708 14 \u65e5\u3002[\u7535\u5b50\u7248\u5148\u884c\u5370\u5237]\u6d88\u8017\u7532\u57fa\u8f6c\u79fb\u9176 Suv39h1 \u53ef\u6539\u5584 DNA \u4fee\u590d\u5e76\u5ef6\u957f\u65e9\u8870\u75c7\u5c0f\u9f20\u6a21\u578b\u7684\u5bff\u547d\u3002
<\/a>\u5218 B\uff0c\u738b Z\uff0c\u5f20 L\uff0cGhosh S\uff0c\u90d1 H\uff0c\u5468 Z\u3002\u00a0\u56fd\u5bb6\u901a\u8baf\u793e<\/i>. 2013;4:1868.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN127″ module_id=”HGADFN127″ _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN127<\/strong><\/h4>\n

\u5bf9 Hutchinson-Gilford \u65e9\u8870\u75c7\u60a3\u8005\u7684\u8f6c\u5f55\u7ec4\u5206\u6790\u63ed\u793a\u4e86\u65e9\u8870\u86cb\u767d\u7684\u4e3b\u8981\u9776\u901a\u8def<\/a>
Vidak S\u3001Kim S\u3001Misteli T. \u9884\u5370\u672c\u3002\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125\u3002\u53d1\u8868\u4e8e2025\u5e749\u670820\u65e5\u3002doi:10.1101\/2025.09.18.677125<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d miR-145 \u548c miR-27b \u5931\u8c03\uff1a\u5bf9\u8102\u80aa\u751f\u6210\u7684\u5f71\u54cd<\/a>
Fenzl FQ\u3001Lederer EM\u3001Brumma L \u7b49\u3002 \u8001\u9f84\u5316\uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09<\/em>. 2025\u5e748\u670827\u65e5\u5728\u7ebf\u53d1\u8868\u3002doi:10.18632\/aging.206309<\/p>\n

miR-181a\u5bf9\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u60a3\u8005SIRT1\u8868\u8fbe\u548c\u8870\u8001\u7684\u5f71\u54cd<\/a>
Lederer EM\u3001Fenzl FQ\u3001Kr\u00fcger P\u3001Schroll M\u3001Hartinger R\u3001Djabali K. \u75be\u75c5<\/em>. 2025;13(8):245. \u53d1\u8868\u4e8e2025\u5e748\u67084\u65e5\u3002doi:10.3390\/diseases13080245<\/p>\n

\u589e\u5f3a\u7ec6\u80de\u7a33\u6001\uff1a\u9776\u5411\u690d\u7269\u5316\u5408\u7269\u589e\u5f3a\u6b63\u5e38\u548c\u8fc7\u65e9\u8870\u8001\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u7ec6\u80de\u5065\u5eb7\u529f\u80fd<\/a>
\u54c8\u5ef7\u683c R\u3001\u8f9b\u683c K\u3001\u83b1\u5f17\u91cc\u7279 J\u3001\u8d3e\u5df4\u5229 K. \u751f\u7269\u5206\u5b50<\/em>. 2024;14(10):1310\u30022024 \u5e74 10 \u6708 16 \u65e5\u53d1\u5e03\u3002doi:10.3390\/biom14101310<\/p>\n

\u4ea8\u5ef7\u987f\u6c0f\u75c5\u60a3\u8005\u539f\u53d1\u6027\u76ae\u80a4\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u5f02\u5e38\u8fc1\u79fb\u7279\u5f81\u6709\u53ef\u80fd\u5229\u7528\u57fa\u4e8e\u56fe\u50cf\u7684\u673a\u5668\u5b66\u4e60\u5de5\u5177\u63ed\u793a\u75be\u75c5\u8fdb\u5c55<\/a>
Gharaba S\u3001Shalem A\u3001Paz O\u3001Muchtar N\u3001Wolf L\u3001Weil M\u3002 \u8ba1\u7b97\u673a\u751f\u7269\u533b\u5b66<\/em>\u30022024 \u5e74 8 \u6708 2 \u65e5\u5728\u7ebf\u53d1\u8868\u3002doi:10.1016\/j.compbiomed.2024.108970<\/p>\n

\u901a\u8fc7\u5185\u6838\u819c\u86cb\u767d SUN2 \u6fc0\u6d3b\u5185\u8d28\u7f51\u5e94\u6fc0\u5bfc\u81f4\u8fc7\u65e9\u8870\u8001<\/a>
Vidak S\u3001Serebryannyy LA\u3001Pegoraro G\u3001Misteli T.\u00a0\u624b\u673a\u4ee3\u8868<\/em>\u3002 2023\uff1b42(5)\uff1a112534\u3002 doi:10.1016\/j.celrep.2023.112534<\/p>\n

\u751f\u957f\u7d20\u91ca\u653e\u80bd\u5ef6\u7f13\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u60a3\u8005\u7684\u8fc7\u65e9\u8870\u8001<\/a>
Ferreira-Marques M\u3001Carvalho A\u3001Franco AC \u7b49\u4eba\u3002\u751f\u957f\u7d20\u91ca\u653e\u80bd\u53ef\u5ef6\u7f13\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u60a3\u8005\u7684\u8fc7\u65e9\u8870\u8001 [2023 \u5e74 10 \u6708 19 \u65e5\u5728\u7ebf\u53d1\u8868]\u3002\u00a0\u8870\u8001\u7ec6\u80de<\/em>\u3002 2023\uff1be13983\u3002 doi\uff1a10.1111\/acel.13983<\/p>\n

\u6270\u52a8\u808c\u52a8\u86cb\u767d\u5e3d\u4f5c\u4e3a\u4ea8\u5ef7\u987f\u6c0f\u75c5\u60a3\u8005\u539f\u53d1\u6027\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u7684\u4e00\u79cd\u65b0\u7684\u4e2a\u6027\u5316\u751f\u7269\u6807\u5fd7\u7269<\/a>
Gharaba S\u3001Paz O\u3001Feld L\u3001Abashidze A\u3001Weinrab M\u3001Muchtar N\u3001Baransi A\u3001Shalem A\u3001Sprecher U\u3001Wolf L\u3001Wolfenson H\u3001Weil M\u3002\u524d\u7ec6\u80de\u5f00\u53d1\u751f\u7269\u5b66\u3002 2023 \u5e74 1 \u6708 18 \u65e5\uff1b11:1013721\u3002 DOI\uff1a10.3389\/fcell.2023.1013721\u3002\u7535\u8bdd\u53f7\u7801\uff1a36743412\uff1b PMCID\uff1aPMC9889876\u3002<\/p>\n

hTERT \u6c38\u751f\u5316 Hutchinson-Gilford \u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u7cfb\u7684\u5efa\u7acb\u548c\u9274\u5b9a<\/a>
Lin H\u3001Mensch J\u3001Haschke M \u7b49\u4eba\u3002Cells\u30022022\uff1b11(18)\uff1a2784\u30022022 \u5e74 9 \u6708 6 \u65e5\u53d1\u5e03\u3002doi:10.3390\/cells11182784<\/p>\n

MnTBAP \u548c\u5df4\u745e\u66ff\u5c3c\u6cbb\u7597\u5bf9\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u5f71\u54cd<\/a>
Vehns E\u3001Arnold R\u3001Djabali K. \u5236\u836f\u516c\u53f8\uff08\u5df4\u585e\u5c14\uff09\u3002 2022\uff1b15(8):945\u3002\u53d1\u5e03\u4e8e 2022 \u5e74 7 \u6708 29 \u65e5\u3002doi:10.3390\/ph15080945<\/p>\n

SerpinE1 \u9a71\u52a8\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u7684\u7ec6\u80de\u81ea\u4e3b\u81f4\u75c5\u4fe1\u53f7<\/a>
Catarinella G\u3001Nicoletti C\u3001Bracaglia A \u7b49\u4eba\u3002\u7ec6\u80de\u6b7b\u4ea1\u75be\u75c5\u3002 2022\uff1b13(8):737\u3002 2022 \u5e74 8 \u6708 26 \u65e5\u53d1\u5e03\u3002doi:10.1038\/s41419-022-05168-y<\/p>\n

JAK-STAT \u6291\u5236\u5242\u5df4\u745e\u66ff\u5c3c\u53ef\u964d\u4f4e\u6cd5\u5462\u57fa\u8f6c\u79fb\u9176\u6291\u5236\u5242 Lonafarnib \u5bf9\u65e9\u8870\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027<\/a>
\u963f\u8bfa\u5fb7\u00b7R\u3001\u7ef4\u6069\u65af\u00b7E\u3001\u5170\u5fb7\u5c14\u00b7H\u3001\u8d3e\u5df4\u5229\u00b7K.\u00a0\u56fd\u9645\u5206\u5b50\u79d1\u5b66\u6742\u5fd7<\/em>. 2021;22(14):7474\u30022021 \u5e74 7 \u6708 12 \u65e5\u53d1\u5e03\u3002doi:10.3390\/ijms22147474<\/p>\n

\u65e9\u8870\u86cb\u767d\u8868\u8fbe\u5bf9\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u76ae\u80a4\u6e90\u6027\u524d\u4f53\u7ec6\u80de\u8102\u80aa\u751f\u6210\u7684\u5f71\u54cd<\/a>
\u7eb3\u5409\u8fea F\u3001\u514b\u9c81\u683c P\u3001\u8d3e\u5df4\u5229 K. \u5355\u5143\u683c<\/em>. 2021;10(7):1598\u30022021 \u5e74 6 \u6708 25 \u65e5\u53d1\u5e03\u3002doi:10.3390\/cells10071598<\/p>\n

\u901a\u8fc7\u76f8\u5206\u79bb\u5b9e\u73b0\u591a\u7ec4\u5206\u7ebf\u7c92\u4f53\u6838\u82f7\u7684\u81ea\u7ec4\u88c5\u3002
<\/a>Feric M\u3001Demarest TG\u3001Tian J\u3001Croteau DL\u3001Bohr VA\u3001Misteli T\u3002EMBO J\u30022021 \u5e74 3 \u6708 15 \u65e5\uff1b40(6):e107165\u3002doi: 10.15252\/embj.2020107165\u3002\u7535\u5b50\u7248 2021 \u5e74 2 \u6708 23 \u65e5\u3002PMID\uff1a33619770\uff1bPMCID\uff1aPMC7957436\u3002<\/p>\n

\u6838\u5b54\u590d\u5408\u4f53\u5728\u590d\u5236\u8870\u8001\u8fc7\u7a0b\u4e2d\u805a\u96c6\u5728\u6b63\u5e38\u548c\u65e9\u8870\u7ec6\u80de\u7684\u7578\u5f62\u6838\u4e2d\u3002
<\/a>R\u00f6hrl JM\u3001Arnold R\u3001Djabali K. Cells\u30022021 \u5e74 1 \u6708 14 \u65e5\uff1b10(1):153\u3002doi\uff1a10.3390\/cells10010153\u3002PMID\uff1a33466669\uff1bPMCID\uff1aPMC7828780\u3002<\/p>\n

\u4eba\u7c7b\u5e73\u6ed1\u808c\u7ec6\u80de\u548c\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u7684\u76f4\u63a5\u91cd\u7f16\u7a0b\u63ed\u793a\u4e86\u4e0e\u8870\u8001\u548c\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u76f8\u5173\u7684\u7f3a\u9677<\/a>
Bersini S\u3001Schulte R\u3001Huang L\u3001Tsai H\u3001Hetzer MW\u3002 \u57c3\u5229\u592b<\/em>. 2020 \u5e74 9 \u6708 8 \u65e5\uff1b9\uff1ae54383\u3002doi\uff1a10.7554\/eLife.54383\u3002PMID\uff1a32896271\uff1bPMCID\uff1aPMC7478891\u3002<\/p>\n

\u4f7f\u7528\u5df4\u745e\u66ff\u5c3c\u6291\u5236 JAK-STAT \u4fe1\u53f7\u4f20\u5bfc\u53ef\u51cf\u5c11\u65e9\u8870\u7ec6\u80de\u7684\u708e\u75c7\u5e76\u6539\u5584\u7ec6\u80de\u7a33\u6001<\/a>
\u5218 C\u3001\u963f\u8bfa\u5fb7 R\u3001\u6069\u91cc\u514b\u65af G\u3001\u8d3e\u5df4\u5229 K. \u5355\u5143\u683c<\/em> 2019\uff1b8(10):1276\u30022019 \u5e74 10 \u6708 18 \u65e5\u53d1\u5e03\u3002doi:10.3390\/cells8101276<\/p>\n

\u77ac\u65f6\u5f15\u5165\u4eba\u7c7b\u7aef\u7c92\u9176 mRNA \u53ef\u6539\u5584\u65e9\u8870\u7ec6\u80de\u7684\u7279\u5f81<\/a>
\u674eY\uff0c\u5468G\uff0cBruno IG\uff0c\u7b49\u3002 \u8870\u8001\u7ec6\u80de<\/em> 2019\uff1b18(4):e12979\u3002 doi\uff1a10.1111\/acel.12979<\/p>\n

\u6839\u636e\u4eba\u7c7b\u771f\u76ae\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u8f6c\u5f55\u7ec4\u9884\u6d4b\u5e74\u9f84<\/a>
Fleischer JG\u3001Schulte R\u3001Tsai HH \u7b49\u4eba\u3002 \u57fa\u56e0\u7ec4\u751f\u7269\u5b66<\/em> 2018;19(1):221\u30022018 \u5e74 12 \u6708 20 \u65e5\u53d1\u5e03\u3002doi:10.1186\/s13059-018-1599-6<\/p>\n

\u6cd5\u5462\u57fa\u5316\u7fa7\u57fa\u672b\u7aef\u5c42\u86cb\u767d\u80bd\u7684\u81ea\u566c\u53bb\u9664<\/a>
Lu X\uff0cDjabali K. \u5355\u5143\u683c<\/em> 2018;7(4):33\u30022018 \u5e74 4 \u6708 23 \u65e5\u53d1\u5e03\u3002doi:10.3390\/cells7040033<\/p>\n

\u76ae\u80a4\u548c\u8840\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u65f6\u949f\u5e94\u7528\u4e8e\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u79bb\u4f53\u7814\u7a76<\/a>
Horvath S\u3001Oshima J\u3001Martin GM \u7b49\u4eba\u3002 \u8001\u5316<\/em> (\u94dd<\/p>\n

\u95f4\u6b47\u6027\u4f7f\u7528\u6cd5\u5462\u57fa\u8f6c\u79fb\u9176\u6291\u5236\u5242\u548c\u841d\u535c\u786b\u7d20\u6cbb\u7597\u53ef\u6539\u5584\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u7ec6\u80de\u7a33\u6001\u3002\u00a0<\/a>\u52a0\u5e03\u91cc\u57c3\u5c14 D\u3001\u6c99\u5f17\u91cc DD\u3001\u6208\u767b LB\u3001\u8d3e\u5df4\u5229 K.\u00a0\u80bf\u7624\u9776\u70b9<\/em>\u3002 2017\u5e747\u670818\u65e5\uff1b8(39):64809-64826\u3002 doi\uff1a10.18632\/oncotarget.19363\u3002\u7535\u5b50\u6536\u85cf 2017 \u5e74 9 \u6708 12 \u65e5\u3002<\/p>\n

\u66ff\u7f57\u83ab\u53f8\u90e8\u5206\u633d\u6551\u4e86\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u7ec6\u80de\u8868\u578b\u3002<\/a>
\u52a0\u5e03\u91cc\u57c3\u5c14\u00b7D\u3001\u6208\u767b\u00b7LB\u3001\u8d3e\u5df4\u5229\u00b7K. PLoS\u7efc\u5408<\/em> 2016\uff1b11\uff0812\uff09\uff1ae0168988\u30022016 \u5e74 12 \u6708 29 \u65e5\u53d1\u5e03\u3002doi\uff1a10.1371\/journal.pone.0168988<\/p>\n

\u65e9\u8870\u86cb\u767d\u901a\u8fc7\u6d88\u8017\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u4e2d\u671f\u52a8\u7c92\u7ec6\u80de\u4e2d\u7684 CENP-F \u6765\u635f\u5bb3\u67d3\u8272\u4f53\u7684\u7ef4\u6301<\/a>
\u827e\u65bd V\u3001\u5362 X\u3001\u52a0\u5e03\u91cc\u57c3\u5c14 D\u3001\u8d3e\u5df4\u5229 K. \u80bf\u7624\u9776\u70b9<\/em> 2016;7(17):24700-24718\u3002 doi:10.18632\/oncotarget.8267<\/p>\n

\u4e8c\u7532\u53cc\u80cd\u53ef\u51cf\u8f7b\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u771f\u76ae\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u8870\u8001\u7ec6\u80de\u8868\u578b\u3002<\/a>\u00a0\u6734SK, \u7533OS\u3002\u00a0\u76ae\u80a4\u79d1\u4e13\u5bb6<\/i>. 2017 \u5e74 2 \u6708 13 \u65e5\u3002[\u7535\u5b50\u7248\u5148\u884c\u5370\u5237]<\/p>\n

\u6df1\u5165\u4e86\u89e3\u8870\u8001\u7ec6\u80de\u6a21\u578b\u4e2d\u6c34\u75d8\u5e26\u72b6\u75b1\u75b9\u75c5\u6bd2\u611f\u67d3\uff08\u5e26\u72b6\u75b1\u75b9\uff09\u671f\u95f4\u514d\u75ab\u8870\u8001\u7684\u4f5c\u7528\u3002
<\/a>Kim JA\u3001Park SK\u3001Kumar M\u3001Lee CH \u548c Shin OS\u3002\u00a0\u80bf\u7624\u9776\u70b9<\/i>. 2015 \u5e74 10 \u6708 14 \u65e5\u3002[\u7535\u5b50\u7248\u5148\u884c\u5370\u5237]<\/p>\n

\u841d\u535c\u786b\u7d20\u53ef\u589e\u5f3a\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u7684\u65e9\u8870\u86cb\u767d\u6e05\u9664\u7387\u3002
<\/a>\u52a0\u5e03\u91cc\u57c3\u5c14\u00b7D\u3001\u7f57\u5fb7\u5c14\u00b7D\u3001\u6208\u767b\u00b7LB\u3001\u8d3e\u5df4\u5229\u00b7K.\u00a0\u8870\u8001\u7ec6\u80de<\/i>. 2014\u5e7412\u670816\u65e5\uff1a1-14\u3002<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u86cb\u767d\u8d28\u7ec4\u5b66\u7814\u7a76\uff1a\u4e8c\u7ef4\u8272\u8c31\u6cd5\u5728\u65e9\u8870\u75be\u75c5\u4e2d\u7684\u5e94\u7528\u3002
<\/a>Wang L\uff0cYang W\uff0cJu W\uff0cWang P\uff0cZhao X\uff0cJenkins EC\uff0cBrown WT\uff0cZhong N\u3002\u00a0\u751f\u7269\u5316\u5b66\u4e0e\u751f\u7269\u7269\u7406\u7814\u7a76\u901a\u8baf\u3002<\/i>\u00a02012 \u5e74 1 \u6708 27 \u65e5\uff1b417(4):1119-26\u30022011 \u5e74 12 \u6708 24 \u65e5\u7535\u5b50\u7248\u3002<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d MMP-3 \u7684\u5e74\u9f84\u4f9d\u8d56\u6027\u4e27\u5931\u3002<\/a>
Harten IA\u3001Zahr RS\u3001Lemire JM\u3001Machan JT\u3001Moses MA\u3001Doiron RJ\u3001Curatolo AS\u3001Rothman FG\u3001Wight TN\u3001Toole BP\u3001Gordon LB\u3002\u00a0\u8001\u5e74\u751f\u7269\u79d1\u5b66\u4e0e\u533b\u5b66\u6742\u5fd7<\/em>. 2011\u5e7411\u6708;66(11):1201-7.
<\/strong><\/p>\n

CTP\uff1a\u78f7\u9178\u80c6\u78b1\u80de\u82f7\u9170\u8f6c\u79fb\u9176\u03b1\uff08CCT\u03b1\uff09\u548c\u5c42\u86cb\u767d\u6539\u53d8\u6838\u819c\u7ed3\u6784\u800c\u4e0d\u5f71\u54cd\u78f7\u8102\u9170\u80c6\u78b1\u7684\u5408\u6210\u3002<\/a>
Gehrig K\u3001Ridgway ND\u3002\u00a0\u751f\u7269\u5316\u5b66\u4e0e\u751f\u7269\u7269\u7406\u5b66\u62a5<\/em>. 2011\u5e746\u6708;1811(6):377-85.<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u7684\u5c42\u86cb\u767d A-Rb \u4fe1\u53f7\u4f20\u5bfc\u7f3a\u9677\u53ca\u901a\u8fc7\u6cd5\u5462\u57fa\u8f6c\u79fb\u9176\u6291\u5236\u800c\u9006\u8f6c\u3002<\/a>
Marji J\u3001O'Donoghue SI\u3001Mcclintock D\u3001Satagopam VP\u3001Schneider R\u3001Ratner D\u3001Worman HJ\u3001Gordon LB\u3001Djabali K.\u00a0PLoS\u7efc\u5408<\/em>. 2010\u5e746\u670815\u65e5;5(6):e11132.<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7ec6\u80de\u7684\u673a\u68b0\u654f\u611f\u6027\u548c\u6838\u786c\u5ea6\u589e\u52a0\uff1a\u6cd5\u5462\u57fa\u8f6c\u79fb\u9176\u6291\u5236\u5242\u7684\u5f71\u54cd\u3002<\/a>
Verstraeten VL\uff0cJi JY\uff0c\u5361\u660e\u65af KS\uff0c\u674e RT\uff0cLammerding J\u3002\u00a0\u8870\u8001\u7ec6\u80de\u3002<\/em>\u00a02008\u5e746\u6708;7(3):383-93\u3002<\/p>\n

\u5df2\u77e5\u4f1a\u52a0\u901f\u4eba\u7c7b\u8870\u8001\u7684\u7a81\u53d8\u5c42\u86cb\u767d A \u4f1a\u5f15\u8d77\u6709\u4e1d\u5206\u88c2\u548c\u7ec6\u80de\u5468\u671f\u8fdb\u7a0b\u7684\u6539\u53d8\u3002<\/a>
Dechat T\u3001Shimi T\u3001Adam SA\u3001Rusinol AE\u3001Andres DA\u3001Spielmann HP\u3001Sinensky MS\u3001Goldman RD\u3002\u00a0\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a<\/em>. 2007\u5e743\u670820\u65e5;104(12):4955-60.<\/p>\n

\u5bfc\u81f4\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u7684\u5c42\u86cb\u767d A \u7a81\u53d8\u5f62\u5f0f\u662f\u4eba\u7c7b\u76ae\u80a4\u7ec6\u80de\u8870\u8001\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002<\/a>
\u9ea6\u514b\u6797\u6258\u514b D\u3001\u62c9\u7279\u7eb3 D\u3001\u6d1b\u5e93\u683c M\u3001\u6b27\u6587\u65af DM\u3001\u6208\u767b LB\u3001\u67ef\u6797\u65af FS\u3001\u8d3e\u5df4\u5229 K.\u00a0PLoS\u7efc\u5408<\/em>. 2007 \u5e74 12 \u6708 5 \u65e5;2(12):e1269\u3002<\/p>\n

\u5728\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u771f\u76ae\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\uff0c\u805a\u96c6\u86cb\u767d\u805a\u7cd6\u7684\u8868\u8fbe\u663e\u8457\u4e14\u5f02\u5e38\u4e0a\u8c03\u3002<\/a>
Lemire JM\u3001Patis C\u3001Gordon LB\u3001Sandy JD\u3001Toole BP\u3001Weiss AS\u3002\u00a0\u673a\u68b0\u8001\u5316\u5f00\u53d1<\/em>.<\/em><\/a>\u00a02006\u5e748\u6708;127(8):660-9<\/p>\n

\u901a\u8fc7\u6297\u5c42\u86cb\u767d A G608G \u6297\u4f53\u68c0\u6d4b\uff0c\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u7a81\u53d8\u5c42\u86cb\u767d A \u4e3b\u8981\u9488\u5bf9\u4eba\u7c7b\u8840\u7ba1\u7ec6\u80de\u3002<\/a>
\u9ea6\u514b\u6797\u6258\u514b D\u3001\u6208\u767b LB\u3001\u8d3e\u5df4\u5229 K.\u00a0\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a\u3002<\/em>\u00a02006 \u5e74 2 \u6708 14 \u65e5\uff1b103(7):2154-9\u3002<\/p>\n

\u901a\u8fc7\u836f\u7269\u6cbb\u7597\u633d\u6551\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u4e2d\u7684\u5f02\u67d3\u8272\u8d28\u7ec4\u7ec7\u3002<\/a>
Columbaro M\u3001Capanni C\u3001Mattioli E\u3001Novelli G\u3001Parnaik VK\u3001Squarzoni S\u3001Maraldi NM\u3001Lattanzi G\u3002\u00a0\u7ec6\u80de\u5206\u5b50\u751f\u547d\u79d1\u5b66\u3002<\/em>\u00a02005\u5e7411\u6708;62(22):2669-78\u3002<\/p>\n

\u57fa\u4e8e\u5c42\u86cb\u767d\u75c5\u7684\u8fc7\u65e9\u8870\u8001\u4e2d\u7684\u57fa\u56e0\u7ec4\u4e0d\u7a33\u5b9a\u6027\u3002<\/a>
\u5218 B\u3001\u738b J\u3001\u9648 KM\u3001Tjia WM\u3001\u9093 W\u3001\u5173 X\u3001\u9ec4 JD\u3001\u674e KM\u3001\u5468 PY\u3001\u9648 DJ\u3001\u88f4 D\u3001Pendas AM\u3001Cadi\u00f1anos J\u3001L\u00f3pez-Ot\u00edn C\u3001Tse HF\u3001Hutchison C\u3001\u9648\u6770\uff0c\u66f9Y\uff0cCheah KS\uff0cTryggvason K\uff0c\u5468Z\u3002\u00a0\u5929\u7136\u533b\u5b66\u3002<\/em>\u00a02005\u5e747\u6708;11(7):780-5\u3002<\/p>\n

\u65b0\u578b\u65e9\u8001\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\u4f19\u4f34\u86cb\u767d hnRNP E1\u3001EGF\u3001Mel 18 \u548c UBC9 \u4e0e\u5c42\u86cb\u767d A\/C \u76f8\u4e92\u4f5c\u7528\u3002<\/a>
\u949f\u5b81, Radu G, Ju W, Brown WT. \u751f\u7269\u5316\u5b66\u4e0e\u751f\u7269\u7269\u7406\u7814\u7a76\u901a\u8baf\u3002\u00a0<\/em>2005 \u5e74 12 \u6708 16 \u65e5\uff1b338(2):855-61\u3002<\/p>\n

[\/et_pb_text][et_pb_textadmin_label=\u201dHGADFN136\u2033module_id=\u201dHGADFN136\u2033_builder_version=\u201d4.16\u2033custom_margin=\u201d50px||50px||true\u201dz_index_tablet=\u201d500\u2033global_colors_info=\u201d{}\u201d]<\/p>\n

HGADFN136<\/strong><\/h4>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u4e2d\u7a81\u53d8\u5c42\u86cb\u767d A \u7684\u52a0\u5de5\u4e0d\u5b8c\u5168\u4f1a\u5bfc\u81f4\u6838\u5f02\u5e38\uff0c\u800c\u6cd5\u5462\u57fa\u8f6c\u79fb\u9176\u6291\u5236\u53ef\u4ee5\u9006\u8f6c\u8fd9\u79cd\u5f02\u5e38\u3002<\/a>
Glynn MW\uff0cGlover TW\u3002\u00a0\u4eba\u7c7b\u5206\u5b50\u9057\u4f20\u5b66\u3002\u00a0<\/em>2005\u5e7410\u670815\u65e5;14(20):2959-69\u3002<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN143″ module_id=”HGADFN143″ _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN143<\/strong><\/h4>\n

\u5bf9 Hutchinson-Gilford \u65e9\u8870\u75c7\u60a3\u8005\u7684\u8f6c\u5f55\u7ec4\u5206\u6790\u63ed\u793a\u4e86\u65e9\u8870\u86cb\u767d\u7684\u4e3b\u8981\u9776\u901a\u8def<\/a>
Vidak S\u3001Kim S\u3001Misteli T. \u9884\u5370\u672c\u3002\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125\u3002\u53d1\u8868\u4e8e2025\u5e749\u670820\u65e5\u3002doi:10.1101\/2025.09.18.677125<\/p>\n

\u57fa\u4e8e\u5f02\u620a\u4e8c\u70ef\u534a\u80f1\u6c28\u9178\u7fa7\u7532\u57fa\u8f6c\u79fb\u9176\u7684\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u6cbb\u7597<\/a>
\u9a6c\u79d1\u65af-\u62c9\u7c73\u7f57 B\u3001\u5409\u5c14-\u5965\u5c14\u591a\u6d85\u65af A\u3001\u9a6c\u6797-\u62c9\u83ab\u65af NI \u7b49\u4eba\u3002 \u7f8e\u56fd\u5316\u5b66\u5b66\u4f1a\u79d1\u5b66\u4e2d\u5fc3<\/em>. 2021\uff1b7(8):1300-1310\u3002doi:10.1021\/acscentsci.0c01698<\/p>\n

\u4eba\u7c7b\u5e73\u6ed1\u808c\u7ec6\u80de\u548c\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u7684\u76f4\u63a5\u91cd\u7f16\u7a0b\u63ed\u793a\u4e86\u4e0e\u8870\u8001\u548c\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u76f8\u5173\u7684\u7f3a\u9677<\/a>
Bersini S\u3001Schulte R\u3001Huang L\u3001Tsai H\u3001Hetzer MW\u3002 \u57c3\u5229\u592b<\/em>. 2020 \u5e74 9 \u6708 8 \u65e5\uff1b9\uff1ae54383\u3002doi\uff1a10.7554\/eLife.54383\u3002PMID\uff1a32896271\uff1bPMCID\uff1aPMC7478891\u3002<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u5c42\u76f8\u5173\u57df\u7684\u8868\u89c2\u9057\u4f20\u5931\u8c03<\/a>
K\u00f6hler F\u3001Bormann F\u3001Raddatz G \u7b49\u4eba\u3002 \u57fa\u56e0\u7ec4\u533b\u5b66<\/em>. 2020;12(1):46\u30022020 \u5e74 5 \u6708 25 \u65e5\u53d1\u5e03\u3002doi:10.1186\/s13073-020-00749-y<\/p>\n

PML2 \u4ecb\u5bfc\u7684\u7ebf\u72b6\u6838\u4f53\u6807\u5fd7\u7740\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u665a\u671f\u8870\u8001<\/a>
\u738b\u6885\uff0c\u738b\u73b2\uff0c\u94b1\u6885\u7b49\u3002[2020 \u5e74 4 \u6708 29 \u65e5\u5728\u7ebf\u53d1\u8868\uff0c\u63d0\u524d\u5370\u5237]\u3002 \u8870\u8001\u7ec6\u80de<\/em>.
\u786e\u8ba4\u7ec6\u80de\u7cfb PRF \u7684\u66f4\u6b63\u6b63\u5728\u7b49\u5f85\u4e2d<\/strong><\/p>\n

\u77ac\u65f6\u5f15\u5165\u4eba\u7c7b\u7aef\u7c92\u9176 mRNA \u53ef\u6539\u5584\u65e9\u8870\u7ec6\u80de\u7684\u7279\u5f81<\/a>
\u674eY\uff0c\u5468G\uff0cBruno IG\uff0c\u7b49\u3002 \u8870\u8001\u7ec6\u80de<\/em> 2019\uff1b18(4):e12979\u3002 doi\uff1a10.1111\/acel.12979<\/p>\n

\u6839\u636e\u4eba\u7c7b\u771f\u76ae\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u8f6c\u5f55\u7ec4\u9884\u6d4b\u5e74\u9f84<\/a>
Fleischer JG\u3001Schulte R\u3001Tsai HH \u7b49\u4eba\u3002 \u57fa\u56e0\u7ec4\u751f\u7269\u5b66<\/em> 2018;19(1):221\u30022018 \u5e74 12 \u6708 20 \u65e5\u53d1\u5e03\u3002doi:10.1186\/s13059-018-1599-6<\/p>\n

\u76ae\u80a4\u548c\u8840\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u65f6\u949f\u5e94\u7528\u4e8e\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u79bb\u4f53\u7814\u7a76<\/a>
Horvath S\u3001Oshima J\u3001Martin GM \u7b49\u4eba\u3002 \u8001\u5316<\/em> \uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09\u3002 2018\uff1b10(7):1758-1775\u3002 doi\uff1a10.18632\/aging.101508<\/p>\n

\u6d88\u8017\u7532\u57fa\u8f6c\u79fb\u9176 Suv39h1 \u53ef\u6539\u5584 DNA \u4fee\u590d\u5e76\u5ef6\u957f\u65e9\u8870\u75c7\u5c0f\u9f20\u6a21\u578b\u7684\u5bff\u547d\u3002
<\/a>\u5218 B\uff0c\u738b Z\uff0c\u5f20 L\uff0cGhosh S\uff0c\u90d1 H\uff0c\u5468 Z\u3002\u00a0\u56fd\u5bb6\u901a\u8baf\u793e<\/i>. 2013;4:1868.<\/p>\n

CTP\uff1a\u78f7\u9178\u80c6\u78b1\u80de\u82f7\u9170\u8f6c\u79fb\u9176\u03b1\uff08CCT\u03b1\uff09\u548c\u5c42\u86cb\u767d\u6539\u53d8\u6838\u819c\u7ed3\u6784\u800c\u4e0d\u5f71\u54cd\u78f7\u8102\u9170\u80c6\u78b1\u7684\u5408\u6210\u3002<\/a>
Gehrig K\u3001Ridgway ND\u3002\u00a0\u751f\u7269\u5316\u5b66\u4e0e\u751f\u7269\u7269\u7406\u5b66\u62a5\u3002<\/em>\u00a02011\u5e746\u6708;1811(6):377-85\u3002<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7ec6\u80de\u7684\u673a\u68b0\u654f\u611f\u6027\u548c\u6838\u786c\u5ea6\u589e\u52a0\uff1a\u6cd5\u5462\u57fa\u8f6c\u79fb\u9176\u6291\u5236\u5242\u7684\u5f71\u54cd\u3002<\/a>
Verstraeten VL\uff0cJi JY\uff0c\u5361\u660e\u65af KS\uff0c\u674e RT\uff0cLammerding J\u3002\u00a0\u8870\u8001\u7ec6\u80de\u3002<\/em>\u00a02008\u5e746\u6708;7(3):383-93\u3002<\/p>\n

\u5bfc\u81f4\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u7684\u5c42\u86cb\u767d A \u7a81\u53d8\u5f62\u5f0f\u662f\u4eba\u7c7b\u76ae\u80a4\u7ec6\u80de\u8870\u8001\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002<\/a>
\u9ea6\u514b\u6797\u6258\u514b D\u3001\u62c9\u7279\u7eb3 D\u3001\u6d1b\u5e93\u683c M\u3001\u6b27\u6587\u65af DM\u3001\u6208\u767b LB\u3001\u67ef\u6797\u65af FS\u3001\u8d3e\u5df4\u5229 K.\u00a0PLoS\u7efc\u5408<\/em>. 2007 \u5e74 12 \u6708 5 \u65e5;2(12):e1269\u3002<\/p>\n

\u901a\u8fc7\u6297\u5c42\u86cb\u767d A G608G \u6297\u4f53\u68c0\u6d4b\uff0c\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u7a81\u53d8\u5c42\u86cb\u767d A \u4e3b\u8981\u9488\u5bf9\u4eba\u7c7b\u8840\u7ba1\u7ec6\u80de\u3002<\/a>
\u9ea6\u514b\u6797\u6258\u514b D\u3001\u6208\u767b LB\u3001\u8d3e\u5df4\u5229 K.\u00a0\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a\u3002<\/em>\u00a02006 \u5e74 2 \u6708 14 \u65e5\uff1b103(7):2154-9\u3002<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN155″ module_id=”HGADFN155″ _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

\u54c8\u5c14\u6ee8GADFN155<\/strong><\/h4>\n

\u5728\u65b0\u578b\u7ec6\u80de\u6a21\u578b\u4e2d\u7b5b\u9009\u7279\u5f02\u6027\u5f3a\u3001\u9ad8\u6548\u7684siRNA\u7528\u4e8e\u6cbb\u7597Hutchinson-Gilford\u65e9\u8870\u7efc\u5408\u5f81<\/a>
Dzianisava V\u3001Piekarowicz K\u3001Machowska M\u3001Rzepecki R. \u5206\u5b50\u6cbb\u7597\u6838\u9178<\/em>. 2025;36(4):102727\u3002\u53d1\u8868\u4e8e2025\u5e7410\u67083\u65e5\u3002doi:10.1016\/j.omtn.2025.102727<\/p>\n

\u5bf9 Hutchinson-Gilford \u65e9\u8870\u75c7\u60a3\u8005\u7684\u8f6c\u5f55\u7ec4\u5206\u6790\u63ed\u793a\u4e86\u65e9\u8870\u86cb\u767d\u7684\u4e3b\u8981\u9776\u901a\u8def<\/a>
Vidak S\u3001Kim S\u3001Misteli T. \u9884\u5370\u672c\u3002\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125\u3002\u53d1\u8868\u4e8e2025\u5e749\u670820\u65e5\u3002doi:10.1101\/2025.09.18.677125<\/p>\n

\u8840\u7ba1\u751f\u6210\u7d20-2 \u9006\u8f6c\u65e9\u8870\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u529f\u80fd\u969c\u788d<\/a>
Vakili S\u3001Izydore EK\u3001Losert L \u7b49\u3002\u00a0\u8870\u8001\u7ec6\u80de<\/em>\u3002 2024 \u5e74 10 \u6708 18 \u65e5\u5728\u7ebf\u53d1\u5e03\u3002doi:10.1111\/acel.14375<\/p>\n

NLRP3 \u6291\u5236\u5242 Dapansutrile \u589e\u5f3a\u4e86 lonafarnib \u5bf9\u65e9\u8870\u5c0f\u9f20\u7684\u6cbb\u7597\u4f5c\u7528<\/a>
Muela-Zarzuela I\u3001Suarez-Rivero JM\u3001Boy-Ruiz D \u7b49\u3002 \u8870\u8001\u7ec6\u80de<\/em>\u3002 2024 \u5e74 8 \u6708 27 \u65e5\u5728\u7ebf\u53d1\u5e03\u3002doi:10.1111\/acel.14272<\/p>\n

\u6291\u5236 NLRP3 \u708e\u75c7\u5c0f\u4f53\u53ef\u5ef6\u957f\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u5c0f\u9f20\u6a21\u578b\u7684\u5bff\u547d<\/a>
Gonz\u00e1lez-Dominguez A\u3001Monta\u00f1ez R\u3001Castej\u00f3n-Vega B \u7b49\u4eba\u3002 [\u5370\u5237\u524d\u5728\u7ebf\u53d1\u5e03\uff0c2021 \u5e74 8 \u6708 27 \u65e5]\u3002\u00a0\u6b27\u6d32\u5206\u5b50\u533b\u5b66\u7ec4\u7ec7<\/em>\u3002 2021\uff1be14012\u3002 doi:10.15252\/emmm.202114012<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u5c42\u76f8\u5173\u57df\u7684\u8868\u89c2\u9057\u4f20\u5931\u8c03<\/a>
K\u00f6hler F\u3001Bormann F\u3001Raddatz G \u7b49\u4eba\u3002 \u57fa\u56e0\u7ec4\u533b\u5b66\u3002<\/em> 2020;12(1):46\u30022020 \u5e74 5 \u6708 25 \u65e5\u53d1\u5e03\u3002doi:10.1186\/s13073-020-00749-y<\/p>\n

PML2 \u4ecb\u5bfc\u7684\u7ebf\u72b6\u6838\u4f53\u6807\u5fd7\u7740\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u665a\u671f\u8870\u8001<\/a>
\u738b\u6885\uff0c\u738b\u73b2\uff0c\u94b1\u6885\u7b49\u3002[2020 \u5e74 4 \u6708 29 \u65e5\u5728\u7ebf\u53d1\u8868\uff0c\u63d0\u524d\u5370\u5237]\u3002 \u8870\u8001\u7ec6\u80de<\/em>.
\u786e\u8ba4\u7ec6\u80de\u7cfb PRF \u7684\u66f4\u6b63\u6b63\u5728\u7b49\u5f85\u4e2d<\/strong><\/p>\n

\u77ac\u65f6\u5f15\u5165\u4eba\u7c7b\u7aef\u7c92\u9176 mRNA \u53ef\u6539\u5584\u65e9\u8870\u7ec6\u80de\u7684\u7279\u5f81<\/a>
\u674eY\uff0c\u5468G\uff0cBruno IG\uff0c\u7b49\u3002 \u8870\u8001\u7ec6\u80de<\/em> 2019\uff1b18(4):e12979\u3002 doi\uff1a10.1111\/acel.12979<\/p>\n

\u6cd5\u5462\u57fa\u5316\u7fa7\u57fa\u672b\u7aef\u5c42\u86cb\u767d\u80bd\u7684\u81ea\u566c\u53bb\u9664<\/a>
Lu X\uff0cDjabali K. \u5355\u5143\u683c<\/em> 2018;7(4):33\u30022018 \u5e74 4 \u6708 23 \u65e5\u53d1\u5e03\u3002doi:10.3390\/cells7040033<\/p>\n

\u76ae\u80a4\u548c\u8840\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u65f6\u949f\u5e94\u7528\u4e8e\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u79bb\u4f53\u7814\u7a76<\/a>
Horvath S\u3001Oshima J\u3001Martin GM \u7b49\u4eba\u3002 \u8001\u5316<\/em> \uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09\u3002 2018\uff1b10(7):1758-1775\u3002 doi\uff1a10.18632\/aging.101508<\/p>\n

\u6838\u8d28\u5c42\u86cb\u767d\u51b3\u5b9a\u4e86\u5c42\u86cb\u767d\u76f8\u5173\u591a\u80bd 2\u03b1 \u5728\u65e9\u8870\u7ec6\u80de\u4e2d\u7684\u751f\u957f\u8c03\u8282\u529f\u80fd\u3002<\/a> Vidak S\u3001Georgiou K\u3001Fichtinger P\u3001Naetar N\u3001Dechat T\u3001Foisner R. J \u7ec6\u80de\u79d1\u5b66\u3002 2017 \u5e74 12 \u6708 28 \u65e5\u3002pii\uff1ajcs.208462\u3002 doi\uff1a10.1242\/jcs.208462\u3002 [\u5370\u5237\u524d\u7684\u7535\u5b50\u7248]<\/p>\n

\u95f4\u6b47\u6027\u4f7f\u7528\u6cd5\u5462\u57fa\u8f6c\u79fb\u9176\u6291\u5236\u5242\u548c\u841d\u535c\u786b\u7d20\u6cbb\u7597\u53ef\u6539\u5584\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u7ec6\u80de\u7a33\u6001\u3002\u00a0<\/a>\u52a0\u5e03\u91cc\u57c3\u5c14 D\u3001\u6c99\u5f17\u91cc DD\u3001\u6208\u767b LB\u3001\u8d3e\u5df4\u5229 K.\u00a0\u80bf\u7624\u9776\u70b9<\/em>\u3002 2017\u5e747\u670818\u65e5\uff1b8(39):64809-64826\u3002 doi\uff1a10.18632\/oncotarget.19363\u3002\u7535\u5b50\u6536\u85cf 2017 \u5e74 9 \u6708 12 \u65e5\u3002<\/p>\n

\u66ff\u7f57\u83ab\u53f8\u90e8\u5206\u633d\u6551\u4e86\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u7ec6\u80de\u8868\u578b\u3002<\/a>
\u52a0\u5e03\u91cc\u57c3\u5c14\u00b7D\u3001\u6208\u767b\u00b7LB\u3001\u8d3e\u5df4\u5229\u00b7K. PLoS\u7efc\u5408<\/em> 2016\uff1b11\uff0812\uff09\uff1ae0168988\u30022016 \u5e74 12 \u6708 29 \u65e5\u53d1\u5e03\u3002doi\uff1a10.1371\/journal.pone.0168988<\/p>\n

\u65e9\u8870\u86cb\u767d\u901a\u8fc7\u6d88\u8017\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u4e2d\u671f\u52a8\u7c92\u7ec6\u80de\u4e2d\u7684 CENP-F \u6765\u635f\u5bb3\u67d3\u8272\u4f53\u7684\u7ef4\u6301<\/a>
\u827e\u65bd V\u3001\u5362 X\u3001\u52a0\u5e03\u91cc\u57c3\u5c14 D\u3001\u8d3e\u5df4\u5229 K. \u80bf\u7624\u9776\u70b9<\/em> 2016;7(17):24700-24718\u3002 doi:10.18632\/oncotarget.8267<\/p>\n

\u5c42\u86cb\u767d A \u662f\u4e00\u79cd\u5185\u6e90\u6027 SIRT6 \u6fc0\u6d3b\u5242\uff0c\u53ef\u4fc3\u8fdb SIRT6 \u4ecb\u5bfc\u7684 DNA \u4fee\u590d\u3002<\/a>\u00a0Ghosh S\u3001\u5218 B\u3001\u738b Y\u3001\u90dd Q\u3001\u5468 Z\u3002\u00a0\u624b\u673a\u4ee3\u8868<\/i>. 2015 \u5e74 11 \u6708 17 \u65e5;13(7):1396-1406. doi: 10.1016\/j.celrep.2015.10.006. Epub 2015 \u5e74 11 \u6708 5 \u65e5. PMID:26549451<\/p>\n

\u5c42\u86cb\u767d A \u662f\u4e00\u79cd\u5185\u6e90\u6027 SIRT6 \u6fc0\u6d3b\u5242\uff0c\u53ef\u4fc3\u8fdb SIRT6 \u4ecb\u5bfc\u7684 DNA \u4fee\u590d\u3002
<\/a>Ghosh S\u3001\u5218 B\u3001\u738b Y\u3001\u90dd Q\u3001\u5468 Z\u3002\u00a0\u624b\u673a\u4ee3\u8868<\/i>. 2015 \u5e74 11 \u6708 4 \u65e5\u3002[\u7535\u5b50\u7248\u5148\u884c\u5370\u5237]\u5c42\u76f8\u5173\u591a\u80bd 2\u03b1 (LAP2\u03b1) \u901a\u8fc7\u8868\u8fbe\u7ec6\u80de\u5916\u57fa\u8d28\u86cb\u767d\u6765\u589e\u5f3a\u65e9\u8870\u7ec6\u80de\u7684\u589e\u6b96\u3002
<\/a>\u7ef4\u8fbe\u514b S\u3001\u5e93\u672c N\u3001\u5fb7\u590f\u7279 T\u3001\u798f\u4f0a\u65af\u7eb3 R\u3002\u00a0\u57fa\u56e0\u4e0e\u53d1\u5c55\u3002<\/i>\u00a02015\u5e7410\u67081\u65e5;29(19):2022-36\u3002<\/p>\n

\u841d\u535c\u786b\u7d20\u53ef\u589e\u5f3a\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u7684\u65e9\u8870\u86cb\u767d\u6e05\u9664\u7387\u3002
<\/a>\u52a0\u5e03\u91cc\u57c3\u5c14\u00b7D\u3001\u7f57\u5fb7\u5c14\u00b7D\u3001\u6208\u767b\u00b7LB\u3001\u8d3e\u5df4\u5229\u00b7K.\u00a0\u8870\u8001\u7ec6\u80de<\/i>. 2014\u5e7412\u670816\u65e5\uff1a1-14\u3002<\/p>\n

\u536b\u661f\u5f02\u67d3\u8272\u8d28\u7684\u9ad8\u9636\u5c55\u5f00\u662f\u7ec6\u80de\u8870\u8001\u8fc7\u7a0b\u4e2d\u6301\u7eed\u4e14\u65e9\u671f\u7684\u4e8b\u4ef6\u3002
<\/a>\u65af\u65fa\u68ee EC\u3001\u66fc\u5b81 B\u3001\u5f20 H\u3001\u52b3\u4f26\u65af JB\u3002\u00a0\u7ec6\u80de\u751f\u7269\u5b66\u6742\u5fd7<\/i>. 2013\u5e7412\u670823\u65e5;203(6):929-42\u3002<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u57fa\u56e0\u7ec4\u7ec4\u7ec7\u3001\u7ec4\u86cb\u767d\u7532\u57fa\u5316\u548c DNA-\u5c42\u86cb\u767d A\/C \u76f8\u4e92\u4f5c\u7528\u7684\u76f8\u5173\u6539\u53d8\u3002
<\/a>McCord RP\u3001Nazario-Toole A\u3001Zhang H\u3001Chines PS\u3001Zhan Y\u3001Erdos MR\u3001Collins FS\u3001Dekker J\u3001Cao K\u3002\u00a0\u57fa\u56e0\u7ec4<\/i>\u00a0\u89e3\u6790<\/i>. 2013 \u5e74 2 \u6708;23(2):260-9\u3002\u7535\u5b50\u7248 2012 \u5e74 11 \u6708 14 \u65e5\u3002<\/p>\n

\u65e9\u8001\u7d20\u5728iPS\u7ec6\u80de\u5206\u5316\u8102\u80aa\u7ec6\u80de\u7684\u57fa\u56e0\u8bf1\u5bfc\u7f51\u7edc\u4e2d\u8d77\u6291\u5236\u4f5c\u7528\u3002
<\/a>\u718aZM\uff0cLaDana C\uff0c\u5434D\uff0c\u66f9K.\u00a0\u8001\u5316<\/i>\u00a0\uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09\u3002 2013 \u5e74 4 \u6708\uff1b5(4)\uff1a288-303\u3002<\/p>\n

\u6d88\u8017\u7532\u57fa\u8f6c\u79fb\u9176 Suv39h1 \u53ef\u6539\u5584 DNA \u4fee\u590d\u5e76\u5ef6\u957f\u65e9\u8870\u75c7\u5c0f\u9f20\u6a21\u578b\u7684\u5bff\u547d\u3002
<\/a>\u5218 B\uff0c\u738b Z\uff0c\u5f20 L\uff0cGhosh S\uff0c\u90d1 H\uff0c\u5468 Z\u3002\u00a0\u56fd\u5bb6\u901a\u8baf\u793e<\/i>. 2013;4:1868.<\/p>\n

\u6838\u5f62\u72b6\u7684\u81ea\u52a8\u56fe\u50cf\u5206\u6790\uff1a\u6211\u4eec\u53ef\u4ee5\u4ece\u8fc7\u65e9\u8870\u8001\u7684\u7ec6\u80de\u4e2d\u4e86\u89e3\u5230\u4ec0\u4e48\uff1f
<\/a>Driscoll MK\u3001Albanese JL\u3001Xiong ZM\u3001Mailman M\u3001Losert W\u3001Cao K.\u00a0\u8001\u5316<\/i>\u00a0\uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09\u3002 2012 \u5e74 2 \u6708\uff1b4(2):119-32\u3002<\/p>\n

\u96f7\u5e15\u9709\u7d20\u53ef\u9006\u8f6c\u7ec6\u80de\u8868\u578b\u5e76\u589e\u5f3a\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7ec6\u80de\u4e2d\u7684\u7a81\u53d8\u86cb\u767d\u6e05\u9664\u7387\u3002<\/a>
\u66f9K\uff0c\u683c\u62c9\u9f50\u5965\u6258JJ\uff0c\u5e03\u83b1\u5c14CD\uff0cMazzulli JR\uff0c\u9102\u5c14\u591a\u65afMR\uff0cKrainc D\uff0c\u67ef\u6797\u65afFS\u3002\u00a0\u79d1\u5b66\u7ffb\u8bd1\u533b\u5b66\u3002<\/em>\u00a02011\u5e746\u670829\u65e5;3(89):89ra58\u3002<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u7684\u5c42\u86cb\u767d A-Rb \u4fe1\u53f7\u4f20\u5bfc\u7f3a\u9677\u53ca\u901a\u8fc7\u6cd5\u5462\u57fa\u8f6c\u79fb\u9176\u6291\u5236\u800c\u9006\u8f6c\u3002<\/a>
Marji J\u3001O'Donoghue SI\u3001Mcclintock D\u3001Satagopam VP\u3001Schneider R\u3001Ratner D\u3001Worman HJ\u3001Gordon LB\u3001Djabali K.\u00a0PLoS\u7efc\u5408<\/em>. 2010\u5e746\u670815\u65e5;5(6):e11132.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN164″ module_id=”HGADFN164″ _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN164<\/strong><\/h4>\n

\u5bf9 Hutchinson-Gilford \u65e9\u8870\u75c7\u60a3\u8005\u7684\u8f6c\u5f55\u7ec4\u5206\u6790\u63ed\u793a\u4e86\u65e9\u8870\u86cb\u767d\u7684\u4e3b\u8981\u9776\u901a\u8def<\/a>
Vidak S\u3001Kim S\u3001Misteli T. \u9884\u5370\u672c\u3002\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125\u3002\u53d1\u8868\u4e8e2025\u5e749\u670820\u65e5\u3002doi:10.1101\/2025.09.18.677125<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d miR-145 \u548c miR-27b \u5931\u8c03\uff1a\u5bf9\u8102\u80aa\u751f\u6210\u7684\u5f71\u54cd<\/a>
Fenzl FQ\u3001Lederer EM\u3001Brumma L \u7b49\u3002 \u8001\u9f84\u5316\uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09<\/em>. 2025\u5e748\u670827\u65e5\u5728\u7ebf\u53d1\u8868\u3002doi:10.18632\/aging.206309<\/p>\n

miR-181a\u5bf9\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u60a3\u8005SIRT1\u8868\u8fbe\u548c\u8870\u8001\u7684\u5f71\u54cd<\/a>
Lederer EM\u3001Fenzl FQ\u3001Kr\u00fcger P\u3001Schroll M\u3001Hartinger R\u3001Djabali K. \u75be\u75c5<\/em>. 2025;13(8):245. \u53d1\u8868\u4e8e2025\u5e748\u67084\u65e5\u3002doi:10.3390\/diseases13080245<\/p>\n

\u589e\u5f3a\u7ec6\u80de\u7a33\u6001\uff1a\u9776\u5411\u690d\u7269\u5316\u5408\u7269\u589e\u5f3a\u6b63\u5e38\u548c\u8fc7\u65e9\u8870\u8001\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u7ec6\u80de\u5065\u5eb7\u529f\u80fd<\/a>
\u54c8\u5ef7\u683c R\u3001\u8f9b\u683c K\u3001\u83b1\u5f17\u91cc\u7279 J\u3001\u8d3e\u5df4\u5229 K. \u751f\u7269\u5206\u5b50<\/em>. 2024;14(10):1310\u30022024 \u5e74 10 \u6708 16 \u65e5\u53d1\u5e03\u3002doi:10.3390\/biom14101310<\/p>\n

\u5df4\u745e\u66ff\u5c3c\u548c FTI \u8054\u5408\u6cbb\u7597\u5bf9\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u5176\u4ed6\u8102\u80aa\u8425\u517b\u4e0d\u826f\u6838\u7ea4\u5c42\u86cb\u767d\u75c5\u60a3\u8005\u8102\u80aa\u751f\u6210\u7684\u5f71\u54cd<\/a>
Hartinger R\u3001Lederer EM\u3001Schena E\u3001Lattanzi G\u3001Djabali K. \u7ec6\u80de\u3002 2023\uff1b12(10):1350\u3002\u53d1\u5e03\u4e8e 2023 \u5e74 5 \u6708 9 \u65e5\u3002doi:10.3390\/cells12101350<\/p>\n

hTERT \u6c38\u751f\u5316 Hutchinson-Gilford \u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u7cfb\u7684\u5efa\u7acb\u548c\u9274\u5b9a<\/a>
Lin H\u3001Mensch J\u3001Haschke M \u7b49\u4eba\u3002Cells\u30022022\uff1b11(18)\uff1a2784\u30022022 \u5e74 9 \u6708 6 \u65e5\u53d1\u5e03\u3002doi:10.3390\/cells11182784<\/p>\n

SAMMY-seq \u63ed\u793a\u4e86\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u7efc\u5408\u5f81\u4e2d\u5f02\u67d3\u8272\u8d28\u7684\u65e9\u671f\u6539\u53d8\u548c\u4e8c\u4ef7\u57fa\u56e0\u7684\u5931\u8c03Nat <\/a>
Sebesty\u00e9n E\u3001Marullo F\u3001Lucini F\u3001Petrini C\u3001Bianchi A\u3001Valsoni S\u3001Olivieri I\u3001Antonelli L\u3001Gregoretti F\u3001Oliva G\u3001Ferrari F\u3001Lanzuolo C. Commun\u3002 2020 \u5e74 12 \u6708 8 \u65e5\uff1b11(1):6274\u3002 doi\uff1a10.1038\/s41467-020-20048-9\u3002\u7535\u8bdd\u53f7\u7801\uff1a33293552\uff1b PMCID\uff1aPMC7722762\u3002<\/p>\n

\u4eba\u7c7b\u5e73\u6ed1\u808c\u7ec6\u80de\u548c\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u7684\u76f4\u63a5\u91cd\u7f16\u7a0b\u63ed\u793a\u4e86\u4e0e\u8870\u8001\u548c\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u76f8\u5173\u7684\u7f3a\u9677<\/a>
Bersini S\u3001Schulte R\u3001Huang L\u3001Tsai H\u3001Hetzer MW\u3002 \u57c3\u5229\u592b<\/em>. 2020 \u5e74 9 \u6708 8 \u65e5\uff1b9\uff1ae54383\u3002doi\uff1a10.7554\/eLife.54383\u3002PMID\uff1a32896271\uff1bPMCID\uff1aPMC7478891\u3002<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u5c42\u76f8\u5173\u57df\u7684\u8868\u89c2\u9057\u4f20\u5931\u8c03<\/a>
K\u00f6hler F\u3001Bormann F\u3001Raddatz G \u7b49\u4eba\u3002 \u57fa\u56e0\u7ec4\u533b\u5b66<\/em>. 2020;12(1):46\u30022020 \u5e74 5 \u6708 25 \u65e5\u53d1\u5e03\u3002doi:10.1186\/s13073-020-00749-y<\/p>\n

\u77ac\u65f6\u5f15\u5165\u4eba\u7c7b\u7aef\u7c92\u9176 mRNA \u53ef\u6539\u5584\u65e9\u8870\u7ec6\u80de\u7684\u7279\u5f81<\/a>
\u674eY\uff0c\u5468G\uff0cBruno IG\uff0c\u7b49\u3002 \u8870\u8001\u7ec6\u80de<\/em> 2019\uff1b18(4):e12979\u3002 doi\uff1a10.1111\/acel.12979<\/p>\n

\u4f7f\u7528\u5df4\u745e\u66ff\u5c3c\u6291\u5236 JAK-STAT \u4fe1\u53f7\u4f20\u5bfc\u53ef\u51cf\u5c11\u65e9\u8870\u7ec6\u80de\u7684\u708e\u75c7\u5e76\u6539\u5584\u7ec6\u80de\u7a33\u6001<\/a>
\u5218 C\u3001\u963f\u8bfa\u5fb7 R\u3001\u6069\u91cc\u514b\u65af G\u3001\u8d3e\u5df4\u5229 K. \u5355\u5143\u683c<\/em> 2019\uff1b8(10):1276\u30022019 \u5e74 10 \u6708 18 \u65e5\u53d1\u5e03\u3002doi:10.3390\/cells8101276<\/p>\n

\u4f53\u7ec6\u80de\u7a81\u53d8\u5206\u6790\u786e\u5b9a\u4e86\u539f\u53d1\u6027\u771f\u76ae\u6210\u7ea4\u7ef4\u7ec6\u80de\u4f53\u5916\u8001\u5316\u8fc7\u7a0b\u4e2d\u7684\u9009\u62e9\u8ff9\u8c61<\/a>
Narisu N\u3001Rothwell R\u3001Vrta\u010dnik P \u7b49\u3002 \u8870\u8001\u7ec6\u80de<\/em>\u3002 2019\uff1b18(6):e13010\u3002 doi\uff1a10.1111\/acel.13010<\/p>\n

\u6839\u636e\u4eba\u7c7b\u771f\u76ae\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u8f6c\u5f55\u7ec4\u9884\u6d4b\u5e74\u9f84<\/a>
Fleischer JG\u3001Schulte R\u3001Tsai HH \u7b49\u4eba\u3002 \u57fa\u56e0\u7ec4\u751f\u7269\u5b66<\/em> 2018;19(1):221\u30022018 \u5e74 12 \u6708 20 \u65e5\u53d1\u5e03\u3002doi:10.1186\/s13059-018-1599-6<\/p>\n

\u6210\u9aa8\u7ec6\u80de\u5206\u5316\u8fc7\u7a0b\u4e2d\u7ecf\u5178 \u03b2-Catenin \u4fe1\u53f7\u51cf\u5f31\u5bfc\u81f4\u65e9\u8870\u75c7\u9aa8\u8d28\u51cf\u5c11<\/a>
\u5d14 JY\uff0c\u8d56 JK\uff0c\u718a ZM\uff0c\u7b49\u3002 \u9aa8\u77ff\u7814\u7a76\u6742\u5fd7<\/em> 2018\uff1b33(11):2059-2070\u3002 doi\uff1a10.1002\/jbmr.3549<\/p>\n

\u6cd5\u5462\u57fa\u5316\u7fa7\u57fa\u672b\u7aef\u5c42\u86cb\u767d\u80bd\u7684\u81ea\u566c\u53bb\u9664<\/a>
Lu X\uff0cDjabali K. \u5355\u5143\u683c<\/em>. 2018;7(4):33\u30022018 \u5e74 4 \u6708 23 \u65e5\u53d1\u5e03\u3002doi:10.3390\/cells7040033<\/p>\n

\u76ae\u80a4\u548c\u8840\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u65f6\u949f\u5e94\u7528\u4e8e\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u79bb\u4f53\u7814\u7a76<\/a>
Horvath S\u3001Oshima J\u3001Martin GM \u7b49\u4eba\u3002 \u8001\u5316<\/em> \uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09\u3002 2018\uff1b10(7):1758-1775\u3002 doi\uff1a10.18632\/aging.101508<\/p>\n

\u95f4\u6b47\u6027\u4f7f\u7528\u6cd5\u5462\u57fa\u8f6c\u79fb\u9176\u6291\u5236\u5242\u548c\u841d\u535c\u786b\u7d20\u6cbb\u7597\u53ef\u6539\u5584\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u7ec6\u80de\u7a33\u6001\u3002<\/a>\u52a0\u5e03\u91cc\u57c3\u5c14 D\u3001\u6c99\u5f17\u91cc DD\u3001\u6208\u767b LB\u3001\u8d3e\u5df4\u5229 K.\u00a0\u80bf\u7624\u9776\u70b9<\/em>\u3002 2017\u5e747\u670818\u65e5\uff1b8(39):64809-64826\u3002 doi\uff1a10.18632\/oncotarget.19363\u3002\u7535\u5b50\u6536\u85cf 2017 \u5e74 9 \u6708 12 \u65e5\u3002<\/p>\n

\u66ff\u7f57\u83ab\u53f8\u90e8\u5206\u633d\u6551\u4e86\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u7ec6\u80de\u8868\u578b\u3002<\/a>
\u52a0\u5e03\u91cc\u57c3\u5c14\u00b7D\u3001\u6208\u767b\u00b7LB\u3001\u8d3e\u5df4\u5229\u00b7K. PLoS\u7efc\u5408<\/em> 2016\uff1b11\uff0812\uff09\uff1ae0168988\u30022016 \u5e74 12 \u6708 29 \u65e5\u53d1\u5e03\u3002doi\uff1a10.1371\/journal.pone.0168988<\/p>\n

\u5c42\u86cb\u767d A \u662f\u4e00\u79cd\u5185\u6e90\u6027 SIRT6 \u6fc0\u6d3b\u5242\uff0c\u53ef\u4fc3\u8fdb SIRT6 \u4ecb\u5bfc\u7684 DNA \u4fee\u590d\u3002<\/a>\u00a0Ghosh S\u3001\u5218 B\u3001\u738b Y\u3001\u90dd Q\u3001\u5468 Z\u3002\u00a0\u624b\u673a\u4ee3\u8868<\/i>. 2015 \u5e74 11 \u6708 17 \u65e5;13(7):1396-1406. doi: 10.1016\/j.celrep.2015.10.006. Epub 2015 \u5e74 11 \u6708 5 \u65e5. PMID: 26549451<\/p>\n

\u841d\u535c\u786b\u7d20\u53ef\u589e\u5f3a\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u7684\u65e9\u8870\u86cb\u767d\u6e05\u9664\u7387\u3002
<\/a>\u52a0\u5e03\u91cc\u57c3\u5c14\u00b7D\u3001\u7f57\u5fb7\u5c14\u00b7D\u3001\u6208\u767b\u00b7LB\u3001\u8d3e\u5df4\u5229\u00b7K.\u00a0\u8870\u8001\u7ec6\u80de<\/i>. 2014\u5e7412\u670816\u65e5\uff1a1-14\u3002<\/p>\n

\u901a\u8fc7\u4e0b\u8c03\u805a\uff08ADP-\u6838\u7cd6\uff09\u805a\u5408\u9176 1 \u6765\u63a7\u5236\u65e9\u8870\u75c7\u5e73\u6ed1\u808c\u7ec6\u80de\u6b7b\u4ea1\u7684\u673a\u5236\u3002
<\/a>\u5f20\u8f89, \u718a\u5fd7\u6885, \u66f9\u51ef.\u00a0\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a<\/i>\u00a0US A. 2014 \u5e74 6 \u6708 3 \u65e5\uff1b111(22):E2261-70\u30022014 \u5e74 5 \u6708 19 \u65e5\u7535\u5b50\u7248\u51fa\u7248\u3002<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u57fa\u56e0\u7ec4\u7ec4\u7ec7\u3001\u7ec4\u86cb\u767d\u7532\u57fa\u5316\u548c DNA-\u5c42\u86cb\u767d A\/C \u76f8\u4e92\u4f5c\u7528\u7684\u76f8\u5173\u6539\u53d8\u3002
<\/a>McCord RP\u3001Nazario-Toole A\u3001Zhang H\u3001Chines PS\u3001Zhan Y\u3001Erdos MR\u3001Collins FS\u3001Dekker J\u3001Cao K\u3002\u00a0\u57fa\u56e0\u7ec4<\/i>\u00a0\u89e3\u6790<\/i>. 2013 \u5e74 2 \u6708;23(2):260-9\u3002\u7535\u5b50\u7248 2012 \u5e74 11 \u6708 14 \u65e5\u3002<\/p>\n

\u65e9\u8001\u7d20\u5728iPS\u7ec6\u80de\u5206\u5316\u8102\u80aa\u7ec6\u80de\u7684\u57fa\u56e0\u8bf1\u5bfc\u7f51\u7edc\u4e2d\u8d77\u6291\u5236\u4f5c\u7528\u3002
<\/a>\u718aZM\uff0cLaDana C\uff0c\u5434D\uff0c\u66f9K.\u00a0\u8001\u5316<\/i>\u00a0\uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09\u3002 2013 \u5e74 4 \u6708\uff1b5(4)\uff1a288-303\u3002<\/p>\n

\u6d88\u8017\u7532\u57fa\u8f6c\u79fb\u9176 Suv39h1 \u53ef\u6539\u5584 DNA \u4fee\u590d\u5e76\u5ef6\u957f\u65e9\u8870\u75c7\u5c0f\u9f20\u6a21\u578b\u7684\u5bff\u547d\u3002
<\/a>\u5218 B\uff0c\u738b Z\uff0c\u5f20 L\uff0cGhosh S\uff0c\u90d1 H\uff0c\u5468 Z\u3002\u00a0\u56fd\u5bb6\u901a\u8baf\u793e<\/i>. 2013;4:1868.<\/p>\n

\u60a3\u6709\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u60a3\u8005\u7684\u5e7c\u7a1a\u6210\u4f53\u5e72\u7ec6\u80de\u5728\u4f53\u5185\u8868\u8fbe\u4f4e\u6c34\u5e73\u7684\u65e9\u8870\u86cb\u767d\u3002
<\/a>Wenzel V\u3001Roedl D\u3001Gabriel D\u3001Gordon LB\u3001Herlyn M\u3001Schneider R\u3001Ring J\u3001Djabali K\u3002
\u751f\u7269\u5b66\u5f00\u653e\u671f\u520a\u3002<\/i>\u00a02012 \u5e74 6 \u6708 15 \u65e5\uff1b1(6):516-26\u3002\u7535\u5b50\u7248 2012 \u5e74 4 \u6708 16 \u65e5\u3002<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u7684\u5c42\u86cb\u767d A-Rb \u4fe1\u53f7\u4f20\u5bfc\u7f3a\u9677\u53ca\u901a\u8fc7\u6cd5\u5462\u57fa\u8f6c\u79fb\u9176\u6291\u5236\u800c\u9006\u8f6c\u3002<\/a>Marji J\u3001O'Donoghue SI\u3001Mcclintock D\u3001Satagopam VP\u3001Schneider R\u3001Ratner D\u3001Worman HJ\u3001Gordon LB\u3001Djabali K.\u00a0PLoS\u7efc\u5408<\/i>. 2010\u5e746\u670815\u65e5;5(6):e11132.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN167″ module_id=”HGADFN167″ _builder_version=”4.27.5″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN167<\/strong><\/h4>\n

\u7b2c\u4e00\u4ee3\u86cb\u767d\u6c34\u89e3\u9776\u5411\u5d4c\u5408\u4f53\uff08PROTACs\uff09\u7528\u4e8e\u6cbb\u7597\u65e9\u8870\u75c7<\/a>
Macicior-Michelena J\u3001Telechea M\u3001Fern\u00e1ndez D\u3001Garc\u00eda-Mart\u00edn A\u3001Canales \u00c1\u3001Ortega-Guti\u00e9rrez S.\u00a0\u9ad8\u7ea7\u79d1\u5b66\uff08Weinh\uff09<\/em>. \u5728\u7ebf\u53d1\u8868\u4e8e2026\u5e743\u670823\u65e5\u3002doi:10.1002\/advs.202521608<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u4f1a\u6539\u53d8\u5185\u76ae\u7ec6\u80de\u5bf9\u5c42\u6d41\u526a\u5207\u5e94\u529b\u7684\u9057\u4f20\u53cd\u5e94<\/a>
Kennedy CC\u3001Carter JL\u3001Truskey GA\u3002.\u00a0\u751f\u7406\u5b66\u524d\u6cbf<\/em>. 2026;16:1599339\u3002\u53d1\u8868\u4e8e2026\u5e742\u670824\u65e5\u3002doi:10.3389\/fphys.2025.1599339<\/p>\n

\u5728\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u4e2d\u751f\u6210\u975e\u6574\u5408\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff1a\u4fc3\u8fdb\u8870\u8001\u7814\u7a76<\/a>
Kadiwala J, Shakur R.\u00a0\u8001\u5e74\u533b\u5b66\uff08\u7c73\u5c14\u987f\uff09<\/em>. 2025;8(5):493-498\u30022025\u5e749\u670822\u65e5\u53d1\u8868\u3002doi:10.1002\/agm2.70041<\/p>\n

\u6838\u652f\u67b6\u7684\u64cd\u63a7\u589e\u5f3a\u4e86\u7ec6\u80de\u91cd\u7f16\u7a0b\u52a8\u529b\u5b66<\/a>
\u6768 BA\u3001Vesga-Castro C\u3001Monteiro da Rocha A \u7b49\u3002 PNAS Nexus<\/em>. 2025;4(10):pgaf307\u3002\u53d1\u8868\u4e8e2025\u5e749\u670825\u65e5\u3002doi:10.1093\/pnasnexus\/pgaf307<\/p>\n

\u4eba\u7c7bBPIFB4\u57fa\u56e0\u7684\u4e00\u79cd\u4e0e\u957f\u5bff\u76f8\u5173\u7684\u53d8\u5f02\u4f53\u53ef\u9884\u9632\u65e9\u8870\u5c0f\u9f20\u7684\u8212\u5f20\u529f\u80fd\u969c\u788d\u3002<\/a>
\u90b1 Y, Cattaneo M, Maciag A, Puca AA, Madeddu P.\u00a0\u4fe1\u53f7\u8f6c\u5bfc\u9776\u5411\u6cbb\u7597<\/em>2025;10(1):314\u3002\u53d1\u8868\u4e8e2025\u5e749\u670829\u65e5\u3002doi:10.1038\/s41392-025-02416-3<\/p>\n

\u5bf9 Hutchinson-Gilford \u65e9\u8870\u75c7\u60a3\u8005\u7684\u8f6c\u5f55\u7ec4\u5206\u6790\u63ed\u793a\u4e86\u65e9\u8870\u86cb\u767d\u7684\u4e3b\u8981\u9776\u901a\u8def<\/a>
Vidak S\u3001Kim S\u3001Misteli T. \u9884\u5370\u672c\u3002\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125\u3002\u53d1\u8868\u4e8e2025\u5e749\u670820\u65e5\u3002doi:10.1101\/2025.09.18.677125<\/p>\n

\u8840\u7ba1\u751f\u6210\u7d20-2 \u9006\u8f6c\u65e9\u8870\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u529f\u80fd\u969c\u788d<\/a>
Vakili S\u3001Izydore EK\u3001Losert L \u7b49\u3002\u00a0\u8870\u8001\u7ec6\u80de<\/em>\u3002 2024 \u5e74 10 \u6708 18 \u65e5\u5728\u7ebf\u53d1\u5e03\u3002doi:10.1111\/acel.14375<\/p>\n

\u975e HGPS \u60a3\u8005\u7684\u65e9\u8001\u7d20 mRNA \u8868\u8fbe\u4e0e\u8f6c\u5f55\u5f02\u6784\u4f53\u7684\u5e7f\u6cdb\u8f6c\u53d8\u76f8\u5173<\/a>
Yu R\u3001Xue H\u3001Lin W\u3001Collins FS\u3001Mount SM\u3001Cao K. NAR \u57fa\u56e0\u7ec4\u751f\u7269\u4fe1\u606f<\/em>. 2024;6(3):lqae115\u30022024 \u5e74 8 \u6708 29 \u65e5\u53d1\u5e03\u3002doi:10.1093\/nargab\/lqae115<\/p>\n

\u4ece\u6838\u5916\u56f4\u6307\u5bfc\u6838\u7cd6\u4f53\u7684\u751f\u7269\u53d1\u751f<\/a>
Zhuang Y, Guo X, Razorenova OV, Miles CE, Zhao W, Shi X. bioRxiv [\u9884\u5370\u672c]\u30022024 \u5e74 6 \u6708 22 \u65e5\uff1a2024.06.21.597078\u3002doi\uff1a10.1101\/2024.06.21.597078\u3002PMID\uff1a38948754\uff1bPMCID\uff1aPMC11212990\u3002<\/p>\n

\u901a\u8fc7\u5185\u6838\u819c\u86cb\u767d SUN2 \u6fc0\u6d3b\u5185\u8d28\u7f51\u5e94\u6fc0\u5bfc\u81f4\u8fc7\u65e9\u8870\u8001<\/a>
Vidak S\u3001Serebryannyy LA\u3001Pegoraro G\u3001Misteli T.\u00a0\u624b\u673a\u4ee3\u8868<\/em>\u3002 2023\uff1b42(5)\uff1a112534\u3002 doi:10.1016\/j.celrep.2023.112534<\/p>\n

\u643a\u5e26 LMNA \u57fa\u56e0\u53d8\u5f02 c.1824 C > T \u7684 Hutchinson-Gilford \u65e9\u8870\u75c7\u60a3\u8005\u5fc3\u808c\u7ec6\u80de\u6a21\u578b<\/a>
Perales S\u3001Sigamani V\u3001Rajasingh S\u3001Czirok A\u3001Rajasingh J. [\u5728\u5370\u5237\u524d\u5728\u7ebf\u53d1\u5e03\uff0c2023 \u5e74 8 \u6708 12 \u65e5]\u3002\u00a0\u7ec6\u80de\u7ec4\u7ec7\u7814\u7a76<\/em>\u3002 2023\uff1b10.1007\/s00441-023-03813-2\u3002 doi:10.1007\/s00441-023-03813-2<\/p>\n

\u72ec\u7279\u7684\u65e9\u8870\u86cb\u767d C \u7aef\u80bd\u901a\u8fc7\u62ef\u6551 BUBR1 \u6539\u5584\u4e86\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u8868\u578b\u3002<\/a>
Zhang N, Hu Q, Sui T, Fu L, Zhang X, Wang Y, Zhu X, Huang B, Lu J, Li Z, Zhang Y. Nat Aging. 2023 \u5e74 2 \u6708;3(2):185-201\u3002doi: 10.1038\/s43587-023-00361-w\u30022023 \u5e74 2 \u6708 2 \u65e5\u7535\u5b50\u7248\u3002\u52d8\u8bef\u8868\uff0c\u8f7d\u4e8e\uff1aNat Aging\u30022023 \u5e74 5 \u6708 2 \u65e5\uff1bPMID\uff1a37118121\uff1bPMCID\uff1aPMC10154249\u3002<\/p>\n

\u6d1b\u7eb3\u6cd5\u5c3c\u548c\u4f9d\u7ef4\u83ab\u53f8\u53ef\u51cf\u8f7b\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81 iPSC \u884d\u751f\u7ec4\u7ec7\u5de5\u7a0b\u8840\u7ba1\u6a21\u578b\u4e2d\u7684\u75c5\u7406\u3002<\/a>
Abutaleb NO\u3001Atchison L\u3001Choi L\u3001Bedapudi A\u3001Shores K\u3001Gete Y\u3001Cao K\u3001Truskey GA\u3002Sci Rep. 2023 \u5e74 3 \u6708 28 \u65e5\uff1b13(1):5032\u3002doi\uff1a10.1038\/s41598-023-32035-3\u3002PMID\uff1a36977745\uff1bPMCID\uff1aPMC10050176\u3002<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u8f6c\u5f55\u8c31\u63ed\u793a\u4e86\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5206\u5316\u627f\u8bfa\u7684\u7f3a\u9677\uff0c\u8fd9\u4e0e\u8f6f\u9aa8\u5185\u9aa8\u5316\u65e9\u671f\u4e8b\u4ef6\u6709\u5173<\/a>
San Martin R\u3001Das P\u3001Sanders JT\u3001Hill AM\u3001McCord RP\u3002[\u4e8e 2022 \u5e74 12 \u6708 29 \u65e5\u63d0\u524d\u5728\u7ebf\u53d1\u8868]\u3002\u00a0\u57c3\u5229\u592b<\/em>. 2022\uff1b11\uff1ae81290\u3002doi\uff1a10.7554\/eLife.81290<\/p>\n

\u5728\u76f4\u63a5\u6742\u4ea4\u57fa\u56e0\u7ec4\u6210\u50cf\u4e2d\u5b9e\u73b0\u5355\u6838\u82f7\u9178\u7075\u654f\u5ea6<\/a>
\u738b Y\uff0cCottle WT\uff0c\u738b H \u7b49\u3002\u00a0\u56fd\u5bb6\u901a\u8baf\u793e<\/em>. 2022;13(1):7776\u30022022 \u5e74 12 \u6708 15 \u65e5\u53d1\u5e03\u3002doi:10.1038\/s41467-022-35476-y<\/p>\n

Anti-hsa-miR-59 \u53ef\u7f13\u89e3\u5c0f\u9f20\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u76f8\u5173\u7684\u8fc7\u65e9\u8870\u8001<\/a>
\u80e1\u5029\u3001\u5f20\u5a1c\u3001\u968b\u5a77\u7b49\u3002[2022 \u5e74 11 \u6708 16 \u65e5\u5728\u7ebf\u53d1\u8868\uff0c\u63d0\u524d\u5370\u5237]\u3002\u00a0\u6b27\u6d32\u5206\u5b50\u751f\u7269\u5b66\u6742\u5fd7<\/em>\u3002 2022\uff1be110937\u3002 doi:10.15252\/embj.2022110937<\/p>\n

\u901a\u8fc7\u8d28\u8c31\u6cd5\u5bf9\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u60a3\u8005\u7ec6\u80de\u4e2d\u7684\u6cd5\u5462\u57fa\u5316\u65e9\u8870\u86cb\u767d\u8fdb\u884c\u5b9a\u91cf\u5206\u6790<\/a>
Camafeita E\u3001Jorge I\u3001Rivera-Torres J\u3001Andr\u00e9s V\u3001V\u00e1zquez J\u3002 Int J Mol Sci\u3002 2022\uff1b23(19):11733\u3002\u53d1\u5e03\u4e8e 2022 \u5e74 10 \u6708 3 \u65e5\u3002doi:10.3390\/ijms231911733<\/p>\n

\u5c42\u86cb\u767d\u548c\u6838\u5f62\u6001\u7684\u8054\u5408\u6539\u53d8\u5f71\u54cd\u80bf\u7624\u76f8\u5173\u56e0\u5b50 AKTIP \u7684\u5b9a\u4f4d<\/a>
\u62c9\u6258\u96f7 M\u3001\u6885\u91cc\u5229\u4e9a\u8bfa C\u3001\u9a6c\u5361\u7f57\u5c3c K \u7b49\u4eba\u3002 \u5b9e\u9a8c\u4e34\u5e8a\u764c\u75c7\u7814\u7a76\u6742\u5fd7<\/em>. 2022;41(1):273\u30022022 \u5e74 9 \u6708 13 \u65e5\u53d1\u5e03\u3002doi:10.1186\/s13046-022-02480-5<\/p>\n

SerpinE1 \u9a71\u52a8\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u7684\u7ec6\u80de\u81ea\u4e3b\u81f4\u75c5\u4fe1\u53f7<\/a>
Catarinella G\u3001Nicoletti C\u3001Bracaglia A \u7b49\u4eba\u3002\u7ec6\u80de\u6b7b\u4ea1\u75be\u75c5\u3002 2022\uff1b13(8):737\u3002 2022 \u5e74 8 \u6708 26 \u65e5\u53d1\u5e03\u3002doi:10.1038\/s41419-022-05168-y<\/p>\n

LEF1 \u6fc0\u6d3b\u53d7\u635f\u52a0\u901f\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d iPSC \u884d\u751f\u7684\u89d2\u8d28\u5f62\u6210\u7ec6\u80de\u5206\u5316<\/a>
Mao X\u3001Xiong ZM\u3001Xue H \u7b49\u4eba\u3002Int J Mol Sci. 2022\uff1b23(10):5499\u30022022 \u5e74 5 \u6708 14 \u65e5\u53d1\u5e03\u3002doi:10.3390\/ijms23105499<\/p>\n

\u57fa\u4e8e\u5f02\u620a\u4e8c\u70ef\u534a\u80f1\u6c28\u9178\u7fa7\u7532\u57fa\u8f6c\u79fb\u9176\u7684\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u6cbb\u7597<\/a>
\u9a6c\u79d1\u65af-\u62c9\u7c73\u7f57 B\u3001\u5409\u5c14-\u5965\u5c14\u591a\u6d85\u65af A\u3001\u9a6c\u6797-\u62c9\u83ab\u65af NI \u7b49\u4eba\u3002 \u7f8e\u56fd\u5316\u5b66\u5b66\u4f1a\u79d1\u5b66\u4e2d\u5fc3<\/em>. 2021\uff1b7(8):1300-1310\u3002doi:10.1021\/acscentsci.0c01698<\/p>\n

\u7aef\u7c92\u9176\u7597\u6cd5\u53ef\u9006\u8f6c\u65e9\u8870\u5c0f\u9f20\u7684\u8840\u7ba1\u8870\u8001\u5e76\u5ef6\u957f\u5176\u5bff\u547d<\/a>
Mojiri A\u3001Walther BK\u3001Jiang C \u7b49\u4eba\u3002[2021 \u5e74 8 \u6708 14 \u65e5\u63d0\u524d\u5728\u7ebf\u53d1\u8868]\u3002\u00a0\u6b27\u6d32\u5fc3\u810f\u6742\u5fd7<\/em>. 2021\uff1behab547.doi:10.1093\/eurheartj\/ehab547<\/p>\n

\u901a\u8fc7\u4e0b\u8c03\u5185\u76ae\u578b NOS \u5bfc\u81f4\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u8840\u7ba1\u751f\u6210\u7f3a\u9677\u7684\u673a\u5236\u3002<\/a>
Gete YG\u3001Koblan LW\u3001Mao X\u3001Trappio M\u3001Mahadik B\u3001Fisher JP\u3001Liu DR\u3001Cao K. \u8870\u8001\u7ec6\u80de\u30022021 \u5e74 6 \u6708 4 \u65e5\uff1ae13388\u3002doi\uff1a10.1111\/acel.13388\u3002\u7535\u5b50\u7248\u63d0\u524d\u5370\u5237\u3002PMID\uff1a34086398\u3002<\/p>\n

\u9488\u5bf9\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u53cd\u4e49\u9776\u5411\u6cbb\u7597\u65b9\u6cd5
<\/a>\u9102\u5c14\u591a\u65af MR\u3001\u5361\u5e03\u62c9\u5c14 WA\u3001\u5854\u74e6\u96f7\u65af UL\u3001\u66f9 K\u3001\u683c\u6c83\u5179\u5fb7\u8bfa\u7ef4\u5947-\u8036\u96f7\u7c73\u5947 J\u3001\u7eb3\u91cc\u82cf N\u3001\u6cfd\u6cd5\u65af PM\u3001\u514b\u9c81\u59c6\u5229 S\u3001\u535a\u5e93 Y\u3001\u6c49\u68ee G\u3001\u7a46\u91cc\u5947 DV\u3001\u79d1\u5c14 R\u3001\u57c3\u514b\u8c6a\u65af MA\u3001\u6208\u767b LB\u3001\u67ef\u6797\u65af FS\u3002\u7eb3\u7279\u533b\u5b66\u3002 2021 \u5e74 3 \u6708\uff1b27(3):536-545\u3002 DOI\uff1a10.1038\/s41591-021-01274-0\u3002 Epub 2021 \u5e74 3 \u6708 11 \u65e5\u3002PMID\uff1a33707773\u3002<\/p>\n

\u4f53\u5185\u78b1\u57fa\u7f16\u8f91\u633d\u6551\u4e86\u5c0f\u9f20\u7684\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u3002
<\/a>Koblan LW\u3001Erdos MR\u3001Wilson C\u3001Cabral WA\u3001Levy JM\u3001Xiong ZM\u3001Tavarez UL\u3001Davison LM\u3001Gete YG\u3001Mao X\u3001Newby GA\u3001Doherty SP\u3001Narisu N\u3001Sheng Q\u3001Krilow C\u3001Lin CY\u3001Gordon LB \uff0c\u66f9K\uff0c\u67ef\u6797\u65afFS\uff0c\u5e03\u6717JD\uff0c\u5218\u535a\u58eb\u3002\u81ea\u7136\u3002 2021 \u5e74 1 \u6708\uff1b589(7843):608-614\u3002 DOI\uff1a10.1038\/s41586-020-03086-7\u3002 Epub 2021 \u5e74 1 \u6708 6 \u65e5\u3002PMID\uff1a33408413\uff1b PMCID\uff1aPMC7872200\u3002<\/p>\n

\u901a\u8fc7\u76f8\u5206\u79bb\u5b9e\u73b0\u591a\u7ec4\u5206\u7ebf\u7c92\u4f53\u6838\u82f7\u7684\u81ea\u7ec4\u88c5\u3002
<\/a>Feric M\u3001Demarest TG\u3001Tian J\u3001Croteau DL\u3001Bohr VA\u3001Misteli T\u3002EMBO J\u30022021 \u5e74 3 \u6708 15 \u65e5\uff1b40(6):e107165\u3002doi: 10.15252\/embj.2020107165\u3002\u7535\u5b50\u7248 2021 \u5e74 2 \u6708 23 \u65e5\u3002PMID\uff1a33619770\uff1bPMCID\uff1aPMC7957436\u3002<\/p>\n

SAMMY-seq \u63ed\u793a\u4e86\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u7efc\u5408\u5f81\u4e2d\u5f02\u67d3\u8272\u8d28\u7684\u65e9\u671f\u6539\u53d8\u548c\u4e8c\u4ef7\u57fa\u56e0\u7684\u5931\u8c03Nat <\/a>
Sebesty\u00e9n E\u3001Marullo F\u3001Lucini F\u3001Petrini C\u3001Bianchi A\u3001Valsoni S\u3001Olivieri I\u3001Antonelli L\u3001Gregoretti F\u3001Oliva G\u3001Ferrari F\u3001Lanzuolo C. Commun\u3002 2020 \u5e74 12 \u6708 8 \u65e5\uff1b11(1):6274\u3002 doi\uff1a10.1038\/s41467-020-20048-9\u3002\u7535\u8bdd\u53f7\u7801\uff1a33293552\uff1b PMCID\uff1aPMC7722762\u3002<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u5c42\u76f8\u5173\u57df\u7684\u8868\u89c2\u9057\u4f20\u5931\u8c03<\/a>
K\u00f6hler F\u3001Bormann F\u3001Raddatz G \u7b49\u4eba\u3002 \u57fa\u56e0\u7ec4\u533b\u5b66<\/em>. 2020;12(1):46\u30022020 \u5e74 5 \u6708 25 \u65e5\u53d1\u5e03\u3002doi:10.1186\/s13073-020-00749-y<\/p>\n

iPSC \u884d\u751f\u7684\u5185\u76ae\u7ec6\u80de\u5f71\u54cd\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7ec4\u7ec7\u5de5\u7a0b\u8840\u7ba1\u6a21\u578b\u4e2d\u7684\u8840\u7ba1\u529f\u80fd<\/a>
Atchison L\u3001Abutaleb NO\u3001Snyder-Mounts E \u7b49\u4eba\u3002 \u5e72\u7ec6\u80de\u62a5\u544a<\/em> 2020\uff1b14(2):325-337\u3002 doi:10.1016\/j.stemcr.2020.01.005<\/p>\n

\u67d3\u8272\u8d28\u548c\u7ec6\u80de\u9aa8\u67b6\u675f\u7f1a\u51b3\u5b9a\u8868\u8fbe\u65e9\u8001\u86cb\u767d\u7684\u7ec6\u80de\u7684\u6838\u5f62\u6001<\/a>
Lionetti MC\u3001Bonfanti S\u3001Fumagalli MR\u3001Budrikis Z\u3001Font-Clos F\u3001Costantini G\u3001Chepizhko O\u3001Zapperi S\u3001La Porta CAM\u3002 \u751f\u7269\u7269\u7406\u6742\u5fd7<\/em> 2020\u5e745\u67085\u65e5;118(9):2319-2332\u3002<\/p>\n

\u6838\u5185\u90e8\u7684\u78f7\u9178\u5316\u5c42\u86cb\u767d A\/C \u4e0e\u65e9\u8870\u75c7\u4e2d\u7684\u5f02\u5e38\u8f6c\u5f55\u76f8\u5173\u7684\u6d3b\u6027\u589e\u5f3a\u5b50\u7ed3\u5408<\/a>
Ikegami K\u3001Secchia S\u3001Almakki O\u3001Lieb JD\u3001Moskowitz IP\u3002 \u5f00\u53d1\u5355\u5143<\/em> 2020;52(6):699\u2010713.e11\u3002 doi:10.1016\/j.devcel.2020.02.011<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u7684\u8fc7\u6c27\u5316\u7269\u9176\u4f53\u5f02\u5e38\u548c\u8fc7\u6c27\u5316\u6c22\u9176\u7f3a\u4e4f\u75c7<\/a>
\u6bdbX\uff0cBharti P\uff0cThaivalappil A\uff0c\u66f9K. \u8001\u5316<\/em> \uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff092020\uff1b12(6)\uff1a5195\u20105208\u3002 doi\uff1a10.18632\/aging.102941<\/p>\n

\u77ac\u65f6\u5f15\u5165\u4eba\u7c7b\u7aef\u7c92\u9176 mRNA \u53ef\u6539\u5584\u65e9\u8870\u7ec6\u80de\u7684\u7279\u5f81<\/a>
\u674eY\uff0c\u5468G\uff0cBruno IG\uff0c\u7b49\u3002 \u8870\u8001\u7ec6\u80de<\/em> 2019\uff1b18(4):e12979\u3002 doi\uff1a10.1111\/acel.12979<\/p>\n

\u6062\u590d\u8870\u8001\u5e72\u7ec6\u80de\u7684\u7ec6\u80de\u5916\u57fa\u8d28\u5408\u6210<\/a>
Rong N\uff0cMistriotis P\uff0cWang X \u7b49\u3002 \u7f8e\u56fd\u5b9e\u9a8c\u751f\u7269\u5b66\u5b66\u4f1a\u8054\u5408\u4f1a<\/em>\u3002 2019;33(10):10954-10965\u3002 doi:10.1096\/fj.201900377R<\/p>\n

\u6838\u7ec6\u80de\u9aa8\u67b6\u8fde\u63a5\u4e0d\u5e73\u8861\u5bfc\u81f4\u65e9\u8870\u548c\u751f\u7406\u8870\u8001\u4e2d\u5e38\u89c1\u7684\u6781\u6027\u7f3a\u9677<\/a>
Chang W\u3001\u738b Y\u3001Luxton GWG\u3001\u00d6stlund C\u3001Worman HJ\u3001Gundersen GG\u3002\u00a0 \u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a<\/em> 2019\uff1b116(9):3578-3583\u3002 doi:10.1073\/pnas.1809683116<\/p>\n

\u6839\u636e\u4eba\u7c7b\u771f\u76ae\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u8f6c\u5f55\u7ec4\u9884\u6d4b\u5e74\u9f84<\/a>
Fleischer JG\u3001Schulte R\u3001Tsai HH \u7b49\u4eba\u3002 \u57fa\u56e0\u7ec4\u751f\u7269\u5b66<\/em> 2018;19(1):221\u30022018 \u5e74 12 \u6708 20 \u65e5\u53d1\u5e03\u3002doi:10.1186\/s13059-018-1599-6<\/p>\n

\u6210\u9aa8\u7ec6\u80de\u5206\u5316\u8fc7\u7a0b\u4e2d\u7ecf\u5178 \u03b2-Catenin \u4fe1\u53f7\u51cf\u5f31\u5bfc\u81f4\u65e9\u8870\u75c7\u9aa8\u8d28\u51cf\u5c11<\/a>
\u5d14 JY\uff0c\u8d56 JK\uff0c\u718a ZM\uff0c\u7b49\u3002 \u9aa8\u77ff\u7814\u7a76\u6742\u5fd7<\/em> 2018\uff1b33(11):2059-2070\u3002 doi\uff1a10.1002\/jbmr.3549<\/p>\n

\u4f9d\u7ef4\u83ab\u53f8\u53ef\u633d\u6551\u5c42\u86cb\u767d\u75c5\u60a3\u8005\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u7684\u591a\u79cd\u7ec6\u80de\u7f3a\u9677<\/a>
DuBose AJ\u3001Lichtenstein ST\u3001Petrash NM\u3001Erdos MR\u3001Gordon LB\u3001Collins FS [\u5df2\u53d1\u8868\u7684\u66f4\u6b63\u51fa\u73b0\u5728 Proc Natl Acad Sci US A. 2018 \u5e74 4 \u6708 16 \u65e5\uff1b:]\u3002 \u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a<\/em> 2018\uff1b115(16):4206-4211\u3002 doi:10.1073\/pnas.1802811115<\/p>\n

Smurf2 \u8c03\u8282\u5c42\u86cb\u767d A \u53ca\u5176\u75be\u75c5\u76f8\u5173\u5f62\u5f0f\u65e9\u8001\u86cb\u767d\u7684\u7a33\u5b9a\u6027\u548c\u81ea\u566c\u6eb6\u9176\u4f53\u7684\u5468\u8f6c\u3002
<\/a>Borroni AP\u3001Emanuelli A\u3001Shah PA\u3001Ili\u0107 N\u3001Apel-Sarid L\u3001Paolini B\u3001Manikoth Ayyathan D\u3001Koganti P\u3001Levy-Cohen G\u3001Blank M\u3002\u00a0\u8870\u8001\u7ec6\u80de<\/em>\u30022018 \u5e74 2 \u6708 5 \u65e5\u3002doi\uff1a10.1111\/acel.12732\u3002[\u7535\u5b50\u7248\u63d0\u524d\u5370\u5237]\u3002<\/p>\n

\u7ec6\u80de\u5185\u5728\u5e72\u6270\u7d20\u6837\u53cd\u5e94\u5c06\u590d\u5236\u538b\u529b\u4e0e\u65e9\u8870\u7d20\u5f15\u8d77\u7684\u7ec6\u80de\u8870\u8001\u8054\u7cfb\u8d77\u6765\u3002
<\/a>Kreienkamp R\u3001Graziano S\u3001Coll-Bonfill N\u3001Bedia-Diaz G\u3001Cybulla E\u3001Vindigni A\u3001Dorsett D\u3001Kubben N\u3001Batista LFZ\u3001Gonzalo S\u3002\u00a0\u624b\u673a\u4ee3\u8868<\/em>. 2018\u5e742\u670820\u65e5;22(8):2006-2015.<\/p>\n

\u76ae\u80a4\u548c\u8840\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u65f6\u949f\u5e94\u7528\u4e8e\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u79bb\u4f53\u7814\u7a76<\/a>
Horvath S\u3001Oshima J\u3001Martin GM<\/p>\n

\u9274\u5b9a\u65b0\u7684PDE\u03b4\u76f8\u4e92\u4f5c\u7528\u86cb\u767d\u3002\u00a0<\/a>K\u00fcchler P\u3001Zimmermann G\u3001Winzker M\u3001Janning P\u3001Waldmann H\u3001Ziegler S\u3002\u00a0\u751f\u7269\u6709\u673a\u533b\u5b66\u5316\u5b66<\/em>. 2017 \u5e74 8 \u6708 31 \u65e5\u3002pii\uff1aS0968-0896(17)31182-3\u3002doi\uff1a10.1016\/j.bmc.2017.08.033\u3002[\u7535\u5b50\u7248\u5148\u884c\u5370\u5237]\u8fc7\u65e9\u8870\u8001\u8fc7\u7a0b\u4e2d\u6838\u4ec1\u6269\u5f20\u548c\u86cb\u767d\u8d28\u7ffb\u8bd1\u5347\u9ad8\u3002
<\/a>Buchwalter A, Hetzer MW\u3002
Nat Commun. 2017 \u5e74 8 \u6708 30 \u65e5\uff1b8(1):328\u3002doi: 10.1038\/s41467-017-00322-z\u3002<\/p>\n

\u91cd\u65b0\u7f16\u7a0b\u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u53ef\u91cd\u5efa\u6b63\u5e38\u7684\u8868\u89c2\u9057\u4f20\u666f\u89c2\u3002\u00a0<\/a>Chen Z, Chang WY, Etheridge A, Strickfaden H, Jin Z, Palidwor G, Cho JH, Wang K, Kwon SY, Dor\u00e9 C, Raymond A, Hotta A, Ellis J, Kandel RA, Dilworth FJ, Perkins TJ, Hendzel MJ \uff0cGalas DJ\uff0c\u65af\u5766\u798f WL\u3002 \u3002\u8870\u8001\u7ec6\u80de<\/em>. 2017 \u5e74 6 \u6708 8 \u65e5. [\u7535\u5b50\u7248\u5148\u884c\u5370\u5237]\u4e8c\u7532\u53cc\u80cd\u53ef\u51cf\u8f7b\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u771f\u76ae\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u8870\u8001\u7ec6\u80de\u8868\u578b\u3002<\/a>
\u6734SK, \u7533OS\u3002
\u76ae\u80a4\u79d1\u4e13\u5bb6<\/em>. 2017 \u5e74 2 \u6708 13 \u65e5\u3002[\u7535\u5b50\u7248\u5148\u884c\u5370\u5237]H3K9me3 \u7684\u4e22\u5931\u4e0e\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u7684 ATM \u6fc0\u6d3b\u548c\u7ec4\u86cb\u767d H2AX \u78f7\u9178\u5316\u7f3a\u9677\u76f8\u5173\u3002<\/a>\u00a0\u5f20 H\uff0c\u5b59 L\uff0c\u738b K\uff0c\u5434 D\uff0cTrappio M\uff0cWitting C\uff0c\u66f9 K\u3002\u00a0PLoS\u7efc\u5408<\/em>\u3002 2016 \u5e74 12 \u6708 1 \u65e5\uff1b11(12)\uff1ae0167454\u3002 doi\uff1a10.1371\/journal.pone.0167454\u3002<\/p>\n

NANOG \u901a\u8fc7\u6062\u590d\u808c\u52a8\u86cb\u767d\u4e1d\u72b6\u7ec4\u7ec7\u548c SRF \u4f9d\u8d56\u6027\u57fa\u56e0\u8868\u8fbe\u6765\u9006\u8f6c\u8870\u8001\u5e72\u7ec6\u80de\u7684\u6210\u808c\u5206\u5316\u6f5c\u80fd\u3002\u00a0<\/a>Mistriotis P\uff0cBajpai VK\uff0c\u738bX\uff0c\u8363N\uff0cShahini A\uff0cAsmani M\uff0c\u6881MS\uff0c\u738bJ\uff0c\u96f7P\uff0c\u5218S\uff0c\u8d75R\uff0cAndreadis ST\u3002\u00a0\u5e72\u7ec6\u80de<\/em>. 2016 \u5e74 6 \u6708 28 \u65e5\u3002doi: 10.1002\/stem.2452\u3002[\u7535\u5b50\u7248\u5148\u884c\u5370\u5237]<\/p>\n

\u7ef4\u751f\u7d20 D \u53d7\u4f53\u4fe1\u53f7\u6539\u5584\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7ec6\u80de\u8868\u578b<\/a>
Kreienkamp R\u3001Croke M\u3001Neumann MA \u7b49\u3002 \u80bf\u7624\u9776\u70b9<\/em> 2016;7(21):30018-30031\u3002 doi:10.18632\/oncotarget.9065<\/p>\n

\u4e9a\u7532\u84dd\u53ef\u51cf\u8f7b\u65e9\u8870\u75c7\u7684\u6838\u548c\u7ebf\u7c92\u4f53\u5f02\u5e38\u3002
<\/a>\u718aZM\uff0c\u5d14JY\uff0c\u738bK\uff0c\u5f20H\uff0cTariq Z\uff0c\u5434D\uff0cKo E\uff0cLaDana C\uff0cSesaki H\uff0c\u66f9K\u3002\u00a0\u8870\u8001\u7ec6\u80de\u3002<\/i><\/a>\u00a0 2015 \u5e74 12 \u6708 14 \u65e5\u3002[\u7535\u5b50\u7248\u5148\u884c\u5370\u5237]<\/p>\n

\u6df1\u5165\u4e86\u89e3\u8870\u8001\u7ec6\u80de\u6a21\u578b\u4e2d\u6c34\u75d8\u5e26\u72b6\u75b1\u75b9\u75c5\u6bd2\u611f\u67d3\uff08\u5e26\u72b6\u75b1\u75b9\uff09\u671f\u95f4\u514d\u75ab\u8870\u8001\u7684\u4f5c\u7528\u3002
<\/a>Kim JA\u3001Park SK\u3001Kumar M\u3001Lee CH \u548c Shin OS\u3002\u00a0\u80bf\u7624\u9776\u70b9<\/i>. 2015 \u5e74 10 \u6708 14 \u65e5\u3002[\u7535\u5b50\u7248\u5148\u884c\u5370\u5237]<\/p>\n

\u5c42\u76f8\u5173\u591a\u80bd 2\u03b1 (LAP2\u03b1) \u901a\u8fc7\u8868\u8fbe\u7ec6\u80de\u5916\u57fa\u8d28\u86cb\u767d\u6765\u589e\u5f3a\u65e9\u8870\u7ec6\u80de\u7684\u589e\u6b96\u3002
<\/a>\u7ef4\u8fbe\u514b S\u3001\u5e93\u672c N\u3001\u5fb7\u590f\u7279 T\u3001\u798f\u4f0a\u65af\u7eb3 R\u3002\u00a0\u57fa\u56e0\u4e0e\u53d1\u5c55\u3002<\/i>\u00a02015\u5e7410\u67081\u65e5;29(19):2022-36\u3002<\/p>\n

\u968f\u7740\u65e9\u8870\u86cb\u767d\u7684\u8868\u8fbe\uff0c\u6838\u53d8\u786c\u3001\u67d3\u8272\u8d28\u53d8\u8f6f\uff0c\u5bfc\u81f4\u6838\u5bf9\u529b\u7684\u53cd\u5e94\u51cf\u5f31\u3002
<\/a>\u5c55\u4f4d EA\u3001Spagnol ST\u3001Alcoser TA\u3001Dahl KN\u3002\u00a0\u8f6f\u7269\u8d28<\/i>\u3002 2015 \u5e74 8 \u6708 28 \u65e5\uff1b11(32):6412-8\u3002\u7535\u5b50\u7248 2015 \u5e74 7 \u6708 14 \u65e5\u3002<\/p>\n

\u8868\u578b\u4f9d\u8d56\u7684\u5171\u8868\u8fbe\u57fa\u56e0\u7c07\uff1a\u5e94\u7528\u4e8e\u6b63\u5e38\u548c\u8fc7\u65e9\u8870\u8001\u3002
<\/a>\u738bK\uff0c\u8fbe\u65afA\uff0c\u718aZ\uff0c\u66f9K\uff0cHannenhalli S.\u00a0IEEE\/ACM \u8ba1\u7b97\u673a\u4e0e\u751f\u7269\u4fe1\u606f\u5b66\u62a5<\/i>\u00a02015\u5e741-2\u6708;12(1):30-9.<\/p>\n

\u901a\u8fc7\u4e0b\u8c03\u805a\uff08ADP-\u6838\u7cd6\uff09\u805a\u5408\u9176 1 \u6765\u63a7\u5236\u65e9\u8870\u75c7\u5e73\u6ed1\u808c\u7ec6\u80de\u6b7b\u4ea1\u7684\u673a\u5236\u3002
<\/a>\u5f20\u8f89, \u718a\u5fd7\u6885, \u66f9\u51ef.\u00a0\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a<\/i>\u00a0US A. 2014 \u5e74 6 \u6708 3 \u65e5\uff1b111(22):E2261-70\u30022014 \u5e74 5 \u6708 19 \u65e5\u7535\u5b50\u7248\u51fa\u7248\u3002<\/p>\n

\u536b\u661f\u5f02\u67d3\u8272\u8d28\u7684\u9ad8\u9636\u5c55\u5f00\u662f\u7ec6\u80de\u8870\u8001\u8fc7\u7a0b\u4e2d\u6301\u7eed\u4e14\u65e9\u671f\u7684\u4e8b\u4ef6\u3002
<\/a>\u65af\u65fa\u68ee EC\u3001\u66fc\u5b81 B\u3001\u5f20 H\u3001\u52b3\u4f26\u65af JB\u3002\u00a0\u7ec6\u80de\u751f\u7269\u5b66\u6742\u5fd7<\/i>. 2013\u5e7412\u670823\u65e5;203(6):929-42\u3002<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u57fa\u56e0\u7ec4\u7ec4\u7ec7\u3001\u7ec4\u86cb\u767d\u7532\u57fa\u5316\u548c DNA-\u5c42\u86cb\u767d A\/C \u76f8\u4e92\u4f5c\u7528\u7684\u76f8\u5173\u6539\u53d8\u3002
<\/a>McCord RP\u3001Nazario-Toole A\u3001Zhang H\u3001Chines PS\u3001Zhan Y\u3001Erdos MR\u3001Collins FS\u3001Dekker J\u3001Cao K\u3002\u00a0\u57fa\u56e0\u7ec4<\/i>\u00a0\u89e3\u6790<\/i>. 2013 \u5e74 2 \u6708;23(2):260-9\u3002\u7535\u5b50\u7248 2012 \u5e74 11 \u6708 14 \u65e5\u3002<\/p>\n

\u65e9\u8870\uff1a\u4ece\u7ec6\u80de\u751f\u7269\u5b66\u83b7\u5f97\u7684\u8f6c\u5316\u89c1\u89e3\u3002
<\/a>\u6208\u767b LB\uff0c\u66f9 K\uff0c\u67ef\u6797\u65af FS\u3002\u00a0\u7ec6\u80de\u751f\u7269\u5b66\u6742\u5fd7<\/i>. 2012 \u5e74 10 \u6708 1 \u65e5;199(1):9-13\u3002doi: 10.1083\/jcb.201207072\u3002<\/p>\n

\u6838\u5f62\u72b6\u7684\u81ea\u52a8\u56fe\u50cf\u5206\u6790\uff1a\u6211\u4eec\u53ef\u4ee5\u4ece\u8fc7\u65e9\u8870\u8001\u7684\u7ec6\u80de\u4e2d\u4e86\u89e3\u5230\u4ec0\u4e48\uff1f
<\/a>Driscoll MK\u3001Albanese JL\u3001Xiong ZM\u3001Mailman M\u3001Losert W\u3001Cao K.\u00a0\u8001\u5316<\/i>\u00a0\uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09\u3002 2012 \u5e74 2 \u6708\uff1b4(2):119-32\u3002<\/p>\n

\u4e0e\u5404\u79cd\u6838\u7279\u5f02\u6027\u8870\u8001\u75be\u75c5\u76f8\u5173\u7684\u6838\u5f62\u6001\u7684\u8ba1\u7b97\u673a\u56fe\u50cf\u5206\u6790\u3002<\/a>Choi S\u3001Wang W\u3001Ribeiro AJ\u3001Kalinowski A\u3001Gregg SQ\u3001Opresko PL\u3001Niedernhofer LJ\u3001Rohde GK\u3001Dahl KN\u3002\u00a0\u6838<\/i>\u3002 2011 \u5e74 11 \u6708 1 \u65e5\uff1b2(6)\uff1a570-9\u3002\u7535\u5b50\u7248 2011 \u5e74 11 \u6708 1 \u65e5\u3002<\/p>\n

\u96f7\u5e15\u9709\u7d20\u53ef\u9006\u8f6c\u7ec6\u80de\u8868\u578b\u5e76\u589e\u5f3a\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7ec6\u80de\u4e2d\u7684\u7a81\u53d8\u86cb\u767d\u6e05\u9664\u7387\u3002<\/a>
\u66f9K\uff0c\u683c\u62c9\u9f50\u5965\u6258JJ\uff0c\u5e03\u83b1\u5c14CD\uff0cMazzulli JR\uff0c\u9102\u5c14\u591a\u65afMR\uff0cKrainc D\uff0c\u67ef\u6797\u65afFS\u3002\u00a0\u79d1\u5b66\u7ffb\u8bd1\u533b\u5b66\u3002<\/em>\u00a02011\u5e746\u670829\u65e5;3(89):89ra58\u3002<\/p>\n

\u65e9\u8870\u86cb\u767d\u548c\u7aef\u7c92\u529f\u80fd\u969c\u788d\u5171\u540c\u5f15\u53d1\u6b63\u5e38\u4eba\u7c7b\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u7ec6\u80de\u8870\u8001\u3002<\/a>
\u66f9 K\u3001\u5e03\u83b1\u5c14 CD\u3001\u6cd5\u8fbe DA\u3001Kieckhaefer JE\u3001\u5965\u5229\u5f17 M\u3001\u9102\u5c14\u591a\u65af MR\u3001\u7eb3\u8d1d\u5c14 EG\u3001\u67ef\u6797\u65af FS\u3002\u00a0J Clin Invest\u3002<\/em>\u00a02011\u5e747\u67081\u65e5;121(7):2833-44<\/p>\n

CTP\uff1a\u78f7\u9178\u80c6\u78b1\u80de\u82f7\u9170\u8f6c\u79fb\u9176\u03b1\uff08CCT\u03b1\uff09\u548c\u5c42\u86cb\u767d\u6539\u53d8\u6838\u819c\u7ed3\u6784\u800c\u4e0d\u5f71\u54cd\u78f7\u8102\u9170\u80c6\u78b1\u7684\u5408\u6210\u3002<\/a>
Gehrig K\u3001Ridgway ND\u3002\u00a0\u751f\u7269\u5316\u5b66\u4e0e\u751f\u7269\u7269\u7406\u5b66\u62a5<\/em>. 2011\u5e746\u6708;1811(6):377-85.<\/p>\n

\u65e9\u8870\u86cb\u767d\u5bf9\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u60a3\u8005\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u6c27\u5316\u86cb\u767d\u79ef\u7d2f\u7684\u5f71\u54cd\u3002<\/a>
\u7ef4\u7279\u91cc G\u3001\u949f YW\u3001\u65af\u5854\u7279\u66fc ER\u3002\u00a0\u673a\u68b0\u8001\u5316\u5f00\u53d1<\/em>. 2010\u5e741\u6708;131(1):2-8.<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u8fc7\u5ea6\u8868\u8fbe\u7684\u5c42\u86cb\u767d A \u86cb\u767d\u5f02\u6784\u4f53\u4f1a\u5e72\u6270\u65e9\u8870\u75c7\u548c\u6b63\u5e38\u7ec6\u80de\u7684\u6709\u4e1d\u5206\u88c2\u3002<\/a>
\u66f9K\uff0c\u5361\u4f69\u5c14BC\uff0c\u9102\u5c14\u591a\u65afMR\uff0c\u8d3e\u5df4\u5229K\uff0c\u67ef\u6797\u65afFS\u3002\u00a0\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a<\/em>. 2007\u5e743\u670820\u65e5;104(12):4949-54.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGFDFN168″ module_id=”HGFDFN168″ _builder_version=”4.27.5″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGFDFN168<\/strong><\/h4>\n

\u7b2c\u4e00\u4ee3\u86cb\u767d\u6c34\u89e3\u9776\u5411\u5d4c\u5408\u4f53\uff08PROTACs\uff09\u7528\u4e8e\u6cbb\u7597\u65e9\u8870\u75c7<\/a>
Macicior-Michelena J\u3001Telechea M\u3001Fern\u00e1ndez D\u3001Garc\u00eda-Mart\u00edn A\u3001Canales \u00c1\u3001Ortega-Guti\u00e9rrez S.\u00a0\u9ad8\u7ea7\u79d1\u5b66\uff08Weinh\uff09<\/em>. \u5728\u7ebf\u53d1\u8868\u4e8e2026\u5e743\u670823\u65e5\u3002doi:10.1002\/advs.202521608<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u4f1a\u6539\u53d8\u5185\u76ae\u7ec6\u80de\u5bf9\u5c42\u6d41\u526a\u5207\u5e94\u529b\u7684\u9057\u4f20\u53cd\u5e94<\/a>
Kennedy CC\u3001Carter JL\u3001Truskey GA\u3002.\u00a0\u751f\u7406\u5b66\u524d\u6cbf<\/em>. 2026;16:1599339\u3002\u53d1\u8868\u4e8e2026\u5e742\u670824\u65e5\u3002doi:10.3389\/fphys.2025.1599339<\/p>\n

\u6838\u652f\u67b6\u7684\u64cd\u63a7\u589e\u5f3a\u4e86\u7ec6\u80de\u91cd\u7f16\u7a0b\u52a8\u529b\u5b66<\/a>
\u6768 BA\u3001Vesga-Castro C\u3001Monteiro da Rocha A \u7b49\u3002 PNAS Nexus<\/em>. 2025;4(10):pgaf307\u3002\u53d1\u8868\u4e8e2025\u5e749\u670825\u65e5\u3002doi:10.1093\/pnasnexus\/pgaf307<\/p>\n

\u4eba\u7c7bBPIFB4\u57fa\u56e0\u7684\u4e00\u79cd\u4e0e\u957f\u5bff\u76f8\u5173\u7684\u53d8\u5f02\u4f53\u53ef\u9884\u9632\u65e9\u8870\u5c0f\u9f20\u7684\u8212\u5f20\u529f\u80fd\u969c\u788d\u3002<\/a>
\u90b1 Y, Cattaneo M, Maciag A, Puca AA, Madeddu P.\u00a0\u4fe1\u53f7\u8f6c\u5bfc\u9776\u5411\u6cbb\u7597<\/em>2025;10(1):314\u3002\u53d1\u8868\u4e8e2025\u5e749\u670829\u65e5\u3002doi:10.1038\/s41392-025-02416-3<\/p>\n

\u5bf9 Hutchinson-Gilford \u65e9\u8870\u75c7\u60a3\u8005\u7684\u8f6c\u5f55\u7ec4\u5206\u6790\u63ed\u793a\u4e86\u65e9\u8870\u86cb\u767d\u7684\u4e3b\u8981\u9776\u901a\u8def<\/a>
Vidak S\u3001Kim S\u3001Misteli T. \u9884\u5370\u672c\u3002\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125\u3002\u53d1\u8868\u4e8e2025\u5e749\u670820\u65e5\u3002doi:10.1101\/2025.09.18.677125<\/p>\n

\u8840\u7ba1\u751f\u6210\u7d20-2 \u9006\u8f6c\u65e9\u8870\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u529f\u80fd\u969c\u788d<\/a>
Vakili S\u3001Izydore EK\u3001Losert L \u7b49\u3002\u00a0\u8870\u8001\u7ec6\u80de<\/em>\u3002 2024 \u5e74 10 \u6708 18 \u65e5\u5728\u7ebf\u53d1\u5e03\u3002doi:10.1111\/acel.14375<\/p>\n

\u975e HGPS \u60a3\u8005\u7684\u65e9\u8001\u7d20 mRNA \u8868\u8fbe\u4e0e\u8f6c\u5f55\u5f02\u6784\u4f53\u7684\u5e7f\u6cdb\u8f6c\u53d8\u76f8\u5173<\/a>
Yu R\u3001Xue H\u3001Lin W\u3001Collins FS\u3001Mount SM\u3001Cao K. NAR \u57fa\u56e0\u7ec4\u751f\u7269\u4fe1\u606f<\/em>. 2024;6(3):lqae115\u30022024 \u5e74 8 \u6708 29 \u65e5\u53d1\u5e03\u3002doi:10.1093\/nargab\/lqae115<\/p>\n

\u901a\u8fc7\u5185\u6838\u819c\u86cb\u767d SUN2 \u6fc0\u6d3b\u5185\u8d28\u7f51\u5e94\u6fc0\u5bfc\u81f4\u8fc7\u65e9\u8870\u8001<\/a>
Vidak S\u3001Serebryannyy LA\u3001Pegoraro G\u3001Misteli T.\u00a0\u624b\u673a\u4ee3\u8868<\/em>\u3002 2023\uff1b42(5)\uff1a112534\u3002 doi:10.1016\/j.celrep.2023.112534<\/p>\n

\u643a\u5e26 LMNA \u57fa\u56e0\u53d8\u5f02 c.1824 C > T \u7684 Hutchinson-Gilford \u65e9\u8870\u75c7\u60a3\u8005\u5fc3\u808c\u7ec6\u80de\u6a21\u578b<\/a>
Perales S\u3001Sigamani V\u3001Rajasingh S\u3001Czirok A\u3001Rajasingh J. [\u5728\u5370\u5237\u524d\u5728\u7ebf\u53d1\u5e03\uff0c2023 \u5e74 8 \u6708 12 \u65e5]\u3002\u00a0\u7ec6\u80de\u7ec4\u7ec7\u7814\u7a76<\/em>\u3002 2023\uff1b10.1007\/s00441-023-03813-2\u3002 doi:10.1007\/s00441-023-03813-2<\/p>\n

\u72ec\u7279\u7684\u65e9\u8870\u86cb\u767d C \u7aef\u80bd\u901a\u8fc7\u62ef\u6551 BUBR1 \u6539\u5584\u4e86\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u8868\u578b\u3002<\/a>
Zhang N, Hu Q, Sui T, Fu L, Zhang X, Wang Y, Zhu X, Huang B, Lu J, Li Z, Zhang Y. Nat Aging. 2023 \u5e74 2 \u6708;3(2):185-201\u3002doi: 10.1038\/s43587-023-00361-w\u30022023 \u5e74 2 \u6708 2 \u65e5\u7535\u5b50\u7248\u3002\u52d8\u8bef\u8868\uff0c\u8f7d\u4e8e\uff1aNat Aging\u30022023 \u5e74 5 \u6708 2 \u65e5\uff1bPMID\uff1a37118121\uff1bPMCID\uff1aPMC10154249\u3002<\/p>\n

\u6d1b\u7eb3\u6cd5\u5c3c\u548c\u4f9d\u7ef4\u83ab\u53f8\u53ef\u51cf\u8f7b\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81 iPSC \u884d\u751f\u7ec4\u7ec7\u5de5\u7a0b\u8840\u7ba1\u6a21\u578b\u4e2d\u7684\u75c5\u7406\u3002<\/a>
Abutaleb NO\u3001Atchison L\u3001Choi L\u3001Bedapudi A\u3001Shores K\u3001Gete Y\u3001Cao K\u3001Truskey GA\u3002Sci Rep. 2023 \u5e74 3 \u6708 28 \u65e5\uff1b13(1):5032\u3002doi\uff1a10.1038\/s41598-023-32035-3\u3002PMID\uff1a36977745\uff1bPMCID\uff1aPMC10050176\u3002<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u8f6c\u5f55\u8c31\u63ed\u793a\u4e86\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5206\u5316\u627f\u8bfa\u7684\u7f3a\u9677\uff0c\u8fd9\u4e0e\u8f6f\u9aa8\u5185\u9aa8\u5316\u65e9\u671f\u4e8b\u4ef6\u6709\u5173<\/a>
San Martin R\u3001Das P\u3001Sanders JT\u3001Hill AM\u3001McCord RP\u3002[\u4e8e 2022 \u5e74 12 \u6708 29 \u65e5\u63d0\u524d\u5728\u7ebf\u53d1\u8868]\u3002\u00a0\u57c3\u5229\u592b<\/em>. 2022\uff1b11\uff1ae81290\u3002doi\uff1a10.7554\/eLife.81290<\/p>\n

\u901a\u8fc7\u8d28\u8c31\u6cd5\u5bf9\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u60a3\u8005\u7ec6\u80de\u4e2d\u7684\u6cd5\u5462\u57fa\u5316\u65e9\u8870\u86cb\u767d\u8fdb\u884c\u5b9a\u91cf\u5206\u6790<\/a>
Camafeita E\u3001Jorge I\u3001Rivera-Torres J\u3001Andr\u00e9s V\u3001V\u00e1zquez J\u3002 Int J Mol Sci\u3002 2022\uff1b23(19):11733\u3002\u53d1\u5e03\u4e8e 2022 \u5e74 10 \u6708 3 \u65e5\u3002doi:10.3390\/ijms231911733<\/p>\n

LEF1 \u6fc0\u6d3b\u53d7\u635f\u52a0\u901f\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d iPSC \u884d\u751f\u7684\u89d2\u8d28\u5f62\u6210\u7ec6\u80de\u5206\u5316<\/a>
Mao X\u3001Xiong ZM\u3001Xue H \u7b49\u4eba\u3002Int J Mol Sci. 2022\uff1b23(10):5499\u30022022 \u5e74 5 \u6708 14 \u65e5\u53d1\u5e03\u3002doi:10.3390\/ijms23105499<\/p>\n

\u57fa\u4e8e\u5f02\u620a\u4e8c\u70ef\u534a\u80f1\u6c28\u9178\u7fa7\u7532\u57fa\u8f6c\u79fb\u9176\u7684\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u6cbb\u7597<\/a>
\u9a6c\u79d1\u65af-\u62c9\u7c73\u7f57 B\u3001\u5409\u5c14-\u5965\u5c14\u591a\u6d85\u65af A\u3001\u9a6c\u6797-\u62c9\u83ab\u65af NI \u7b49\u4eba\u3002 \u7f8e\u56fd\u5316\u5b66\u5b66\u4f1a\u79d1\u5b66\u4e2d\u5fc3<\/em>. 2021\uff1b7(8):1300-1310\u3002doi:10.1021\/acscentsci.0c01698<\/p>\n

\u7aef\u7c92\u9176\u7597\u6cd5\u53ef\u9006\u8f6c\u65e9\u8870\u5c0f\u9f20\u7684\u8840\u7ba1\u8870\u8001\u5e76\u5ef6\u957f\u5176\u5bff\u547d<\/a>
Mojiri A\u3001Walther BK\u3001Jiang C \u7b49\u4eba\u3002[2021 \u5e74 8 \u6708 14 \u65e5\u63d0\u524d\u5728\u7ebf\u53d1\u8868]\u3002\u00a0\u6b27\u6d32\u5fc3\u810f\u6742\u5fd7<\/em>. 2021\uff1behab547.doi:10.1093\/eurheartj\/ehab547<\/p>\n

\u901a\u8fc7\u4e0b\u8c03\u5185\u76ae\u578b NOS \u5bfc\u81f4\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u8840\u7ba1\u751f\u6210\u7f3a\u9677\u7684\u673a\u5236\u3002<\/a>
Gete YG\u3001Koblan LW\u3001Mao X\u3001Trappio M\u3001Mahadik B\u3001Fisher JP\u3001Liu DR\u3001Cao K. \u8870\u8001\u7ec6\u80de\u30022021 \u5e74 6 \u6708 4 \u65e5\uff1ae13388\u3002doi\uff1a10.1111\/acel.13388\u3002\u7535\u5b50\u7248\u63d0\u524d\u5370\u5237\u3002PMID\uff1a34086398\u3002<\/p>\n

\u9488\u5bf9\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u53cd\u4e49\u9776\u5411\u6cbb\u7597\u65b9\u6cd5
<\/a>\u9102\u5c14\u591a\u65af MR\u3001\u5361\u5e03\u62c9\u5c14 WA\u3001\u5854\u74e6\u96f7\u65af UL\u3001\u66f9 K\u3001\u683c\u6c83\u5179\u5fb7\u8bfa\u7ef4\u5947-\u8036\u96f7\u7c73\u5947 J\u3001\u7eb3\u91cc\u82cf N\u3001\u6cfd\u6cd5\u65af PM\u3001\u514b\u9c81\u59c6\u5229 S\u3001\u535a\u5e93 Y\u3001\u6c49\u68ee G\u3001\u7a46\u91cc\u5947 DV\u3001\u79d1\u5c14 R\u3001\u57c3\u514b\u8c6a\u65af MA\u3001\u6208\u767b LB\u3001\u67ef\u6797\u65af FS\u3002\u7eb3\u7279\u533b\u5b66\u3002 2021 \u5e74 3 \u6708\uff1b27(3):536-545\u3002 DOI\uff1a10.1038\/s41591-021-01274-0\u3002 Epub 2021 \u5e74 3 \u6708 11 \u65e5\u3002PMID\uff1a33707773\u3002<\/p>\n

\u4f53\u5185\u78b1\u57fa\u7f16\u8f91\u633d\u6551\u4e86\u5c0f\u9f20\u7684\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u3002
<\/a>Koblan LW\u3001Erdos MR\u3001Wilson C\u3001Cabral WA\u3001Levy JM\u3001Xiong ZM\u3001Tavarez UL\u3001Davison LM\u3001Gete YG\u3001Mao X\u3001Newby GA\u3001Doherty SP\u3001Narisu N\u3001Sheng Q\u3001Krilow C\u3001Lin CY\u3001Gordon LB \uff0c\u66f9K\uff0c\u67ef\u6797\u65afFS\uff0c\u5e03\u6717JD\uff0c\u5218\u535a\u58eb\u3002\u81ea\u7136\u3002 2021 \u5e74 1 \u6708\uff1b589(7843):608-614\u3002 DOI\uff1a10.1038\/s41586-020-03086-7\u3002 Epub 2021 \u5e74 1 \u6708 6 \u65e5\u3002PMID\uff1a33408413\uff1b PMCID\uff1aPMC7872200\u3002<\/p>\n

\u901a\u8fc7\u76f8\u5206\u79bb\u5b9e\u73b0\u591a\u7ec4\u5206\u7ebf\u7c92\u4f53\u6838\u82f7\u7684\u81ea\u7ec4\u88c5\u3002
<\/a>Feric M\u3001Demarest TG\u3001Tian J\u3001Croteau DL\u3001Bohr VA\u3001Misteli T\u3002EMBO J\u30022021 \u5e74 3 \u6708 15 \u65e5\uff1b40(6):e107165\u3002doi: 10.15252\/embj.2020107165\u3002\u7535\u5b50\u7248 2021 \u5e74 2 \u6708 23 \u65e5\u3002PMID\uff1a33619770\uff1bPMCID\uff1aPMC7957436\u3002<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u5c42\u76f8\u5173\u57df\u7684\u8868\u89c2\u9057\u4f20\u5931\u8c03<\/a>
K\u00f6hler F\u3001Bormann F\u3001Raddatz G \u7b49\u4eba\u3002 \u57fa\u56e0\u7ec4\u533b\u5b66<\/em>. 2020;12(1):46\u30022020 \u5e74 5 \u6708 25 \u65e5\u53d1\u5e03\u3002doi:10.1186\/s13073-020-00749-y<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u7684\u8fc7\u6c27\u5316\u7269\u9176\u4f53\u5f02\u5e38\u548c\u8fc7\u6c27\u5316\u6c22\u9176\u7f3a\u4e4f\u75c7<\/a>
\u6bdbX\uff0cBharti P\uff0cThaivalappil A\uff0c\u66f9K. \u8001\u5316<\/em> \uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff092020\uff1b12(6)\uff1a5195\u20105208\u3002 doi\uff1a10.18632\/aging.102941<\/p>\n

iPSC \u884d\u751f\u7684\u5185\u76ae\u7ec6\u80de\u5f71\u54cd\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7ec4\u7ec7\u5de5\u7a0b\u8840\u7ba1\u6a21\u578b\u4e2d\u7684\u8840\u7ba1\u529f\u80fd<\/a>Atchison L\u3001Abutaleb NO\u3001Snyder-Mounts E \u7b49\u4eba\u3002 \u5e72\u7ec6\u80de\u62a5\u544a<\/em> 2020\uff1b14(2):325-337\u3002 doi:10.1016\/j.stemcr.2020.01.005<\/p>\n

\u6062\u590d\u8870\u8001\u5e72\u7ec6\u80de\u7684\u7ec6\u80de\u5916\u57fa\u8d28\u5408\u6210<\/a>
Rong N\uff0cMistriotis P\uff0cWang X \u7b49\u3002 \u7f8e\u56fd\u5b9e\u9a8c\u751f\u7269\u5b66\u5b66\u4f1a\u8054\u5408\u4f1a<\/em>\u3002 2019;33(10):10954-10965\u3002 doi:10.1096\/fj.201900377R<\/p>\n

\u6838\u7ec6\u80de\u9aa8\u67b6\u8fde\u63a5\u4e0d\u5e73\u8861\u5bfc\u81f4\u65e9\u8870\u548c\u751f\u7406\u8870\u8001\u4e2d\u5e38\u89c1\u7684\u6781\u6027\u7f3a\u9677<\/a>
Chang W\u3001\u738b Y\u3001Luxton GWG\u3001\u00d6stlund C\u3001Worman HJ\u3001Gundersen GG\u3002\u00a0 \u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a<\/em> 2019\uff1b116(9):3578-3583\u3002 doi:10.1073\/pnas.1809683116<\/p>\n

\u6210\u9aa8\u7ec6\u80de\u5206\u5316\u8fc7\u7a0b\u4e2d\u7ecf\u5178 \u03b2-Catenin \u4fe1\u53f7\u51cf\u5f31\u5bfc\u81f4\u65e9\u8870\u75c7\u9aa8\u8d28\u51cf\u5c11<\/a>
\u5d14 JY\uff0c\u8d56 JK\uff0c\u718a ZM\uff0c\u7b49\u3002 \u9aa8\u77ff\u7814\u7a76\u6742\u5fd7<\/em> 2018\uff1b33(11):2059-2070\u3002 doi\uff1a10.1002\/jbmr.3549<\/p>\n

\u4f9d\u7ef4\u83ab\u53f8\u53ef\u633d\u6551\u5c42\u86cb\u767d\u75c5\u60a3\u8005\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u7684\u591a\u79cd\u7ec6\u80de\u7f3a\u9677<\/a>
DuBose AJ\u3001Lichtenstein ST\u3001Petrash NM\u3001Erdos MR\u3001Gordon LB\u3001Collins FS [\u5df2\u53d1\u8868\u7684\u66f4\u6b63\u51fa\u73b0\u5728 Proc Natl Acad Sci USA 2018 \u5e74 4 \u6708 16 \u65e5\uff1b:]\u3002 \u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a<\/em>\u3002 2018\uff1b115(16):4206-4211\u3002 doi\uff1a10.1073\/pnas.1802811115<\/p>\n

Smurf2 \u8c03\u8282\u5c42\u86cb\u767d A \u53ca\u5176\u75be\u75c5\u76f8\u5173\u5f62\u5f0f\u65e9\u8001\u86cb\u767d\u7684\u7a33\u5b9a\u6027\u548c\u81ea\u566c\u6eb6\u9176\u4f53\u7684\u5468\u8f6c\u3002
<\/a>Borroni AP\u3001Emanuelli A\u3001Shah PA\u3001Ili\u0107 N\u3001Apel-Sarid L\u3001Paolini B\u3001Manikoth Ayyathan D\u3001Koganti P\u3001Levy-Cohen G\u3001Blank M\u3002\u00a0\u8870\u8001\u7ec6\u80de<\/em>\u30022018 \u5e74 2 \u6708 5 \u65e5\u3002doi\uff1a10.1111\/acel.12732\u3002[\u7535\u5b50\u7248\u63d0\u524d\u5370\u5237]\u3002<\/p>\n

\u6838\u8d28\u5c42\u86cb\u767d\u51b3\u5b9a\u4e86\u5c42\u86cb\u767d\u76f8\u5173\u591a\u80bd 2\u03b1 \u5728\u65e9\u8870\u7ec6\u80de\u4e2d\u7684\u751f\u957f\u8c03\u8282\u529f\u80fd\u3002<\/a>\u00a0Vidak S\u3001Georgiou K\u3001Fichtinger P\u3001Naetar N\u3001Dechat T\u3001Foisner R. J \u7ec6\u80de\u79d1\u5b66\u3002 2017 \u5e74 12 \u6708 28 \u65e5\u3002pii\uff1ajcs.208462\u3002 doi\uff1a10.1242\/jcs.208462\u3002 [\u5370\u5237\u524d\u7684\u7535\u5b50\u7248]\u8fc7\u65e9\u8870\u8001\u8fc7\u7a0b\u4e2d\u6838\u4ec1\u6269\u5f20\u548c\u86cb\u767d\u8d28\u7ffb\u8bd1\u5347\u9ad8\u3002<\/a>\u00a0Buchwalter A\uff0cHetzer MW\u3002\u7eb3\u7279\u00b7\u5eb7\u59c6. 2017 \u5e74 8 \u6708 30 \u65e5\uff1b8(1):328\u3002 doi\uff1a10.1038\/s41467-017-00322-z\u3002<\/p>\n

\u91cd\u65b0\u7f16\u7a0b\u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u53ef\u91cd\u5efa\u6b63\u5e38\u7684\u8868\u89c2\u9057\u4f20\u666f\u89c2\u3002\u00a0<\/a>Chen Z, Chang WY, Etheridge A, Strickfaden H, Jin Z, Palidwor G, Cho JH, Wang K, Kwon SY, Dor\u00e9 C, Raymond A, Hotta A, Ellis J, Kandel RA, Dilworth FJ, Perkins TJ, Hendzel MJ \uff0cGalas DJ\uff0c\u65af\u5766\u798f WL\u3002 \u3002\u8870\u8001\u7ec6\u80de<\/em>. 2017 \u5e74 6 \u6708 8 \u65e5. [\u7535\u5b50\u7248\u5148\u884c\u5370\u5237]<\/p>\n

H3K9me3 \u7684\u4e22\u5931\u4e0e\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u7684 ATM \u6fc0\u6d3b\u548c\u7ec4\u86cb\u767d H2AX \u78f7\u9178\u5316\u7f3a\u9677\u76f8\u5173\u3002<\/a>\u00a0\u5f20 H\uff0c\u5b59 L\uff0c\u738b K\uff0c\u5434 D\uff0cTrappio M\uff0cWitting C\uff0c\u66f9 K\u3002\u00a0PLoS\u7efc\u5408<\/em>\u3002 2016 \u5e74 12 \u6708 1 \u65e5\uff1b11(12)\uff1ae0167454\u3002 doi\uff1a10.1371\/journal.pone.0167454\u3002<\/p>\n

NANOG \u901a\u8fc7\u6062\u590d\u808c\u52a8\u86cb\u767d\u4e1d\u72b6\u7ec4\u7ec7\u548c SRF \u4f9d\u8d56\u6027\u57fa\u56e0\u8868\u8fbe\u6765\u9006\u8f6c\u8870\u8001\u5e72\u7ec6\u80de\u7684\u6210\u808c\u5206\u5316\u6f5c\u80fd\u3002<\/a>Mistriotis P\uff0cBajpai VK\uff0c\u738bX\uff0c\u8363N\uff0cShahini A\uff0cAsmani M\uff0c\u6881MS\uff0c\u738bJ\uff0c\u96f7P\uff0c\u5218S\uff0c\u8d75R\uff0cAndreadis ST\u3002\u00a0\u5e72\u7ec6\u80de<\/em>. 2016 \u5e74 6 \u6708 28 \u65e5\u3002doi: 10.1002\/stem.2452\u3002[\u7535\u5b50\u7248\u5148\u884c\u5370\u5237]<\/p>\n

\u4e9a\u7532\u84dd\u53ef\u51cf\u8f7b\u65e9\u8870\u75c7\u7684\u6838\u548c\u7ebf\u7c92\u4f53\u5f02\u5e38\u3002
<\/a>\u718aZM\uff0c\u5d14JY\uff0c\u738bK\uff0c\u5f20H\uff0cTariq Z\uff0c\u5434D\uff0cKo E\uff0cLaDana C\uff0cSesaki H\uff0c\u66f9K\u3002\u00a0\u8870\u8001\u7ec6\u80de\u3002<\/i><\/a>\u00a0 2015 \u5e74 12 \u6708 14 \u65e5\u3002[\u7535\u5b50\u7248\u5148\u884c\u5370\u5237]<\/p>\n

\u5c42\u76f8\u5173\u591a\u80bd 2\u03b1 (LAP2\u03b1) \u901a\u8fc7\u8868\u8fbe\u7ec6\u80de\u5916\u57fa\u8d28\u86cb\u767d\u6765\u589e\u5f3a\u65e9\u8870\u7ec6\u80de\u7684\u589e\u6b96\u3002
<\/a>\u7ef4\u8fbe\u514b S\u3001\u5e93\u672c N\u3001\u5fb7\u590f\u7279 T\u3001\u798f\u4f0a\u65af\u7eb3 R\u3002\u00a0\u57fa\u56e0\u4e0e\u53d1\u5c55\u3002<\/i>\u00a02015\u5e7410\u67081\u65e5;29(19):2022-36\u3002<\/p>\n

\u968f\u7740\u65e9\u8870\u86cb\u767d\u7684\u8868\u8fbe\uff0c\u6838\u53d8\u786c\u3001\u67d3\u8272\u8d28\u53d8\u8f6f\uff0c\u5bfc\u81f4\u6838\u5bf9\u529b\u7684\u53cd\u5e94\u51cf\u5f31\u3002
<\/a>\u5c55\u4f4d EA\u3001Spagnol ST\u3001Alcoser TA\u3001Dahl KN\u3002\u00a0\u8f6f\u7269\u8d28<\/i>\u3002 2015 \u5e74 8 \u6708 28 \u65e5\uff1b11(32):6412-8\u3002\u7535\u5b50\u7248 2015 \u5e74 7 \u6708 14 \u65e5\u3002<\/p>\n

\u8868\u578b\u4f9d\u8d56\u7684\u5171\u8868\u8fbe\u57fa\u56e0\u7c07\uff1a\u5e94\u7528\u4e8e\u6b63\u5e38\u548c\u8fc7\u65e9\u8870\u8001\u3002
<\/a>\u738bK\uff0c\u8fbe\u65afA\uff0c\u718aZ\uff0c\u66f9K\uff0cHannenhalli S.\u00a0IEEE\/ACM \u8ba1\u7b97\u673a\u4e0e\u751f\u7269\u4fe1\u606f\u5b66\u62a5<\/i>\u00a02015\u5e741-2\u6708;12(1):30-9.<\/p>\n

\u901a\u8fc7\u4e0b\u8c03\u805a\uff08ADP-\u6838\u7cd6\uff09\u805a\u5408\u9176 1 \u6765\u63a7\u5236\u65e9\u8870\u75c7\u5e73\u6ed1\u808c\u7ec6\u80de\u6b7b\u4ea1\u7684\u673a\u5236\u3002
<\/a>\u5f20\u8f89, \u718a\u5fd7\u6885, \u66f9\u51ef.\u00a0\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a<\/i>\u00a0US A. 2014 \u5e74 6 \u6708 3 \u65e5\uff1b111(22):E2261-70\u30022014 \u5e74 5 \u6708 19 \u65e5\u7535\u5b50\u7248\u51fa\u7248\u3002<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u57fa\u56e0\u7ec4\u7ec4\u7ec7\u3001\u7ec4\u86cb\u767d\u7532\u57fa\u5316\u548c DNA-\u5c42\u86cb\u767d A\/C \u76f8\u4e92\u4f5c\u7528\u7684\u76f8\u5173\u6539\u53d8\u3002
<\/a>McCord RP\u3001Nazario-Toole A\u3001Zhang H\u3001Chines PS\u3001Zhan Y\u3001Erdos MR\u3001Collins FS\u3001Dekker J\u3001Cao K\u3002\u00a0\u57fa\u56e0\u7ec4<\/i>\u00a0\u89e3\u6790<\/i>. 2013 \u5e74 2 \u6708;23(2):260-9\u3002\u7535\u5b50\u7248 2012 \u5e74 11 \u6708 14 \u65e5\u3002<\/p>\n

\u6838\u5f62\u72b6\u7684\u81ea\u52a8\u56fe\u50cf\u5206\u6790\uff1a\u6211\u4eec\u53ef\u4ee5\u4ece\u8fc7\u65e9\u8870\u8001\u7684\u7ec6\u80de\u4e2d\u4e86\u89e3\u5230\u4ec0\u4e48\uff1f
<\/a>Driscoll MK\u3001Albanese JL\u3001Xiong ZM\u3001Mailman M\u3001Losert W\u3001Cao K.\u00a0\u8001\u5316<\/i>\u00a0\uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09\u3002 2012 \u5e74 2 \u6708\uff1b4(2):119-32\u3002<\/p>\n

\u4e0e\u5404\u79cd\u6838\u7279\u5f02\u6027\u8870\u8001\u75be\u75c5\u76f8\u5173\u7684\u6838\u5f62\u6001\u7684\u8ba1\u7b97\u673a\u56fe\u50cf\u5206\u6790\u3002
<\/a>Choi S\u3001Wang W\u3001Ribeiro AJ\u3001Kalinowski A\u3001Gregg SQ\u3001Opresko PL\u3001Niedernhofer LJ\u3001Rohde GK\u3001Dahl KN\u3002\u00a0\u6838<\/i>\u3002 2011 \u5e74 11 \u6708 1 \u65e5\uff1b2(6)\uff1a570-9\u3002\u7535\u5b50\u7248 2011 \u5e74 11 \u6708 1 \u65e5\u3002<\/p>\n

\u96f7\u5e15\u9709\u7d20\u53ef\u9006\u8f6c\u7ec6\u80de\u8868\u578b\u5e76\u589e\u5f3a\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7ec6\u80de\u4e2d\u7684\u7a81\u53d8\u86cb\u767d\u6e05\u9664\u7387\u3002<\/a>
\u66f9K\uff0c\u683c\u62c9\u9f50\u5965\u6258JJ\uff0c\u5e03\u83b1\u5c14CD\uff0cMazzulli JR\uff0c\u9102\u5c14\u591a\u65afMR\uff0cKrainc D\uff0c\u67ef\u6797\u65afFS\u3002\u00a0\u79d1\u5b66\u7ffb\u8bd1\u533b\u5b66\u3002<\/em>\u00a02011\u5e746\u670829\u65e5;3(89):89ra58\u3002<\/p>\n

\u65e9\u8870\u86cb\u767d\u548c\u7aef\u7c92\u529f\u80fd\u969c\u788d\u5171\u540c\u5f15\u53d1\u6b63\u5e38\u4eba\u7c7b\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u7ec6\u80de\u8870\u8001\u3002<\/a>
\u66f9 K\u3001\u5e03\u83b1\u5c14 CD\u3001\u6cd5\u8fbe DA\u3001Kieckhaefer JE\u3001\u5965\u5229\u5f17 M\u3001\u9102\u5c14\u591a\u65af MR\u3001\u7eb3\u8d1d\u5c14 EG\u3001\u67ef\u6797\u65af FS\u3002\u00a0\u4e34\u5e8a\u7814\u7a76\u6742\u5fd7<\/em>.<\/em>\u00a02011\u5e747\u67081\u65e5;121(7):2833-44<\/p>\n

\u65e9\u8870\u86cb\u767d\u5bf9\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u60a3\u8005\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u6c27\u5316\u86cb\u767d\u79ef\u7d2f\u7684\u5f71\u54cd\u3002<\/a>
\u7ef4\u7279\u91cc G\u3001\u949f YW\u3001\u65af\u5854\u7279\u66fc ER\u3002\u00a0\u673a\u68b0\u8001\u5316\u5f00\u53d1<\/em>. 2010\u5e741\u6708;131(1):2-8.<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u8fc7\u5ea6\u8868\u8fbe\u7684\u5c42\u86cb\u767d A \u86cb\u767d\u5f02\u6784\u4f53\u4f1a\u5e72\u6270\u65e9\u8870\u75c7\u548c\u6b63\u5e38\u7ec6\u80de\u7684\u6709\u4e1d\u5206\u88c2\u3002<\/a>
\u66f9K\uff0c\u5361\u4f69\u5c14BC\uff0c\u9102\u5c14\u591a\u65afMR\uff0c\u8d3e\u5df4\u5229K\uff0c\u67ef\u6797\u65afFS\u3002\u00a0\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a<\/em>. 2007\u5e743\u670820\u65e5;104(12):4949-54.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN169″ module_id=”HGADFN169″ _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN169<\/strong><\/h4>\n

\u4eba\u7c7bBPIFB4\u57fa\u56e0\u7684\u4e00\u79cd\u4e0e\u957f\u5bff\u76f8\u5173\u7684\u53d8\u5f02\u4f53\u53ef\u9884\u9632\u65e9\u8870\u5c0f\u9f20\u7684\u8212\u5f20\u529f\u80fd\u969c\u788d\u3002<\/a>
\u90b1 Y, Cattaneo M, Maciag A, Puca AA, Madeddu P.\u00a0\u4fe1\u53f7\u8f6c\u5bfc\u9776\u5411\u6cbb\u7597<\/em>2025;10(1):314\u3002\u53d1\u8868\u4e8e2025\u5e749\u670829\u65e5\u3002doi:10.1038\/s41392-025-02416-3<\/p>\n

\u5bf9 Hutchinson-Gilford \u65e9\u8870\u75c7\u60a3\u8005\u7684\u8f6c\u5f55\u7ec4\u5206\u6790\u63ed\u793a\u4e86\u65e9\u8870\u86cb\u767d\u7684\u4e3b\u8981\u9776\u901a\u8def<\/a>
Vidak S\u3001Kim S\u3001Misteli T. \u9884\u5370\u672c\u3002\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125\u3002\u53d1\u8868\u4e8e2025\u5e749\u670820\u65e5\u3002doi:10.1101\/2025.09.18.677125<\/p>\n

\u4ea8\u5ef7\u987f\u6c0f\u75c5\u60a3\u8005\u539f\u53d1\u6027\u76ae\u80a4\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u5f02\u5e38\u8fc1\u79fb\u7279\u5f81\u6709\u53ef\u80fd\u5229\u7528\u57fa\u4e8e\u56fe\u50cf\u7684\u673a\u5668\u5b66\u4e60\u5de5\u5177\u63ed\u793a\u75be\u75c5\u8fdb\u5c55<\/a>
Gharaba S\u3001Shalem A\u3001Paz O\u3001Muchtar N\u3001Wolf L\u3001Weil M\u3002 \u8ba1\u7b97\u673a\u751f\u7269\u533b\u5b66<\/em>\u30022024 \u5e74 8 \u6708 2 \u65e5\u5728\u7ebf\u53d1\u8868\u3002doi:10.1016\/j.compbiomed.2024.108970<\/p>\n

\u6270\u52a8\u808c\u52a8\u86cb\u767d\u5e3d\u4f5c\u4e3a\u4ea8\u5ef7\u987f\u6c0f\u75c5\u60a3\u8005\u539f\u53d1\u6027\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u7684\u4e00\u79cd\u65b0\u7684\u4e2a\u6027\u5316\u751f\u7269\u6807\u5fd7\u7269<\/a>
Gharaba S\u3001Paz O\u3001Feld L\u3001Abashidze A\u3001Weinrab M\u3001Muchtar N\u3001Baransi A\u3001Shalem A\u3001Sprecher U\u3001Wolf L\u3001Wolfenson H\u3001Weil M\u3002\u524d\u7ec6\u80de\u5f00\u53d1\u751f\u7269\u5b66\u3002 2023 \u5e74 1 \u6708 18 \u65e5\uff1b11:1013721\u3002 DOI\uff1a10.3389\/fcell.2023.1013721\u3002\u7535\u8bdd\u53f7\u7801\uff1a36743412\uff1b PMCID\uff1aPMC9889876\u3002<\/p>\n

SerpinE1 \u9a71\u52a8\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u7684\u7ec6\u80de\u81ea\u4e3b\u81f4\u75c5\u4fe1\u53f7<\/a>
Catarinella G\u3001Nicoletti C\u3001Bracaglia A \u7b49\u4eba\u3002\u7ec6\u80de\u6b7b\u4ea1\u75be\u75c5\u3002 2022\uff1b13(8):737\u3002 2022 \u5e74 8 \u6708 26 \u65e5\u53d1\u5e03\u3002doi:10.1038\/s41419-022-05168-y<\/p>\n

SAMMY-seq \u63ed\u793a\u4e86\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u7efc\u5408\u5f81\u4e2d\u5f02\u67d3\u8272\u8d28\u7684\u65e9\u671f\u6539\u53d8\u548c\u4e8c\u4ef7\u57fa\u56e0\u7684\u5931\u8c03Nat <\/a>
Sebesty\u00e9n E\u3001Marullo F\u3001Lucini F\u3001Petrini C\u3001Bianchi A\u3001Valsoni S\u3001Olivieri I\u3001Antonelli L\u3001Gregoretti F\u3001Oliva G\u3001Ferrari F\u3001Lanzuolo C. Commun\u3002 2020 \u5e74 12 \u6708 8 \u65e5\uff1b11(1):6274\u3002 doi\uff1a10.1038\/s41467-020-20048-9\u3002\u7535\u8bdd\u53f7\u7801\uff1a33293552\uff1b PMCID\uff1aPMC7722762\u3002<\/p>\n

\u4eba\u7c7b\u5e73\u6ed1\u808c\u7ec6\u80de\u548c\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u7684\u76f4\u63a5\u91cd\u7f16\u7a0b\u63ed\u793a\u4e86\u4e0e\u8870\u8001\u548c\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u76f8\u5173\u7684\u7f3a\u9677<\/a>
Bersini S\u3001Schulte R\u3001Huang L\u3001Tsai H\u3001Hetzer MW\u3002 \u57c3\u5229\u592b<\/em>. 2020 \u5e74 9 \u6708 8 \u65e5\uff1b9\uff1ae54383\u3002doi\uff1a10.7554\/eLife.54383\u3002PMID\uff1a32896271\uff1bPMCID\uff1aPMC7478891\u3002<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u5c42\u76f8\u5173\u57df\u7684\u8868\u89c2\u9057\u4f20\u5931\u8c03<\/a>
K\u00f6hler F\u3001Bormann F\u3001Raddatz G \u7b49\u4eba\u3002 \u57fa\u56e0\u7ec4\u533b\u5b66<\/em>. 2020;12(1):46\u30022020 \u5e74 5 \u6708 25 \u65e5\u53d1\u5e03\u3002doi:10.1186\/s13073-020-00749-y<\/p>\n

PML2 \u4ecb\u5bfc\u7684\u7ebf\u72b6\u6838\u4f53\u6807\u5fd7\u7740\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u665a\u671f\u8870\u8001<\/a>
\u738b\u6885\uff0c\u738b\u73b2\uff0c\u94b1\u6885\u7b49\u3002[2020 \u5e74 4 \u6708 29 \u65e5\u5728\u7ebf\u53d1\u8868\uff0c\u63d0\u524d\u5370\u5237]\u3002 \u8870\u8001\u7ec6\u80de<\/em>.
\u786e\u8ba4\u7ec6\u80de\u7cfb PRF \u7684\u66f4\u6b63\u6b63\u5728\u7b49\u5f85\u4e2d<\/strong><\/p>\n

\u77ac\u65f6\u5f15\u5165\u4eba\u7c7b\u7aef\u7c92\u9176 mRNA \u53ef\u6539\u5584\u65e9\u8870\u7ec6\u80de\u7684\u7279\u5f81<\/a>
\u674eY\uff0c\u5468G\uff0cBruno IG\uff0c\u7b49\u3002 \u8870\u8001\u7ec6\u80de<\/em> 2019\uff1b18(4):e12979\u3002 doi\uff1a10.1111\/acel.12979<\/p>\n

\u6839\u636e\u4eba\u7c7b\u771f\u76ae\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u8f6c\u5f55\u7ec4\u9884\u6d4b\u5e74\u9f84<\/a>
Fleischer JG\u3001Schulte R\u3001Tsai HH \u7b49\u4eba\u3002 \u57fa\u56e0\u7ec4\u751f\u7269\u5b66<\/em> 2018;19(1):221\u30022018 \u5e74 12 \u6708 20 \u65e5\u53d1\u5e03\u3002doi:10.1186\/s13059-018-1599-6<\/p>\n

\u76ae\u80a4\u548c\u8840\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u65f6\u949f\u5e94\u7528\u4e8e\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u79bb\u4f53\u7814\u7a76<\/a>
Horvath S\u3001Oshima J\u3001Martin GM \u7b49\u4eba\u3002 \u8001\u5316<\/em> \uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09\u3002 2018\uff1b10(7):1758-1775\u3002 doi\uff1a10.18632\/aging.101508<\/p>\n

\u4e9a\u7532\u84dd\u53ef\u51cf\u8f7b\u65e9\u8870\u75c7\u7684\u6838\u548c\u7ebf\u7c92\u4f53\u5f02\u5e38\u3002
<\/a>\u718aZM\uff0c\u5d14JY\uff0c\u738bK\uff0c\u5f20H\uff0cTariq Z\uff0c\u5434D\uff0cKo E\uff0cLaDana C\uff0cSesaki H\uff0c\u66f9K\u3002\u00a0\u8870\u8001\u7ec6\u80de\u3002<\/i><\/a>\u00a0 2015 \u5e74 12 \u6708 14 \u65e5\u3002[\u7535\u5b50\u7248\u5148\u884c\u5370\u5237]<\/p>\n

\u5c42\u86cb\u767d A \u662f\u4e00\u79cd\u5185\u6e90\u6027 SIRT6 \u6fc0\u6d3b\u5242\uff0c\u53ef\u4fc3\u8fdb SIRT6 \u4ecb\u5bfc\u7684 DNA \u4fee\u590d\u3002<\/a>\u00a0Ghosh S\u3001\u5218 B\u3001\u738b Y\u3001\u90dd Q\u3001\u5468 Z\u3002\u00a0\u624b\u673a\u4ee3\u8868<\/i>. 2015 \u5e74 11 \u6708 17 \u65e5;13(7):1396-1406. doi: 10.1016\/j.celrep.2015.10.006. Epub 2015 \u5e74 11 \u6708 5 \u65e5. PMID:26549451<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u57fa\u56e0\u7ec4\u7ec4\u7ec7\u3001\u7ec4\u86cb\u767d\u7532\u57fa\u5316\u548c DNA-\u5c42\u86cb\u767d A\/C \u76f8\u4e92\u4f5c\u7528\u7684\u76f8\u5173\u6539\u53d8\u3002
<\/a>McCord RP\u3001Nazario-Toole A\u3001Zhang H\u3001Chines PS\u3001Zhan Y\u3001Erdos MR\u3001Collins FS\u3001Dekker J\u3001Cao K\u3002\u00a0\u57fa\u56e0\u7ec4<\/i>\u00a0\u89e3\u6790<\/i>. 2013 \u5e74 2 \u6708;23(2):260-9\u3002\u7535\u5b50\u7248 2012 \u5e74 11 \u6708 14 \u65e5\u3002<\/p>\n

\u6d88\u8017\u7532\u57fa\u8f6c\u79fb\u9176 Suv39h1 \u53ef\u6539\u5584 DNA \u4fee\u590d\u5e76\u5ef6\u957f\u65e9\u8870\u75c7\u5c0f\u9f20\u6a21\u578b\u7684\u5bff\u547d\u3002
<\/a>\u5218 B\uff0c\u738b Z\uff0c\u5f20 L\uff0cGhosh S\uff0c\u90d1 H\uff0c\u5468 Z\u3002\u00a0\u56fd\u5bb6\u901a\u8baf\u793e<\/i>. 2013;4:1868.<\/p>\n

\u96f7\u5e15\u9709\u7d20\u53ef\u9006\u8f6c\u7ec6\u80de\u8868\u578b\u5e76\u589e\u5f3a\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7ec6\u80de\u4e2d\u7684\u7a81\u53d8\u86cb\u767d\u6e05\u9664\u7387\u3002
<\/a>[sta_anchor id=\u201dfn178\u2033 unsan=\u201dFN178\u2033]Cao K\u3001Graziotto JJ\u3001Blair CD\u3001Mazzulli JR\u3001Erdos MR\u3001Krainc D\u3001Collins FS\u3002\u00a0\u79d1\u5b66\u7ffb\u8bd1\u533b\u5b66\u3002<\/i>\u00a02011\u5e746\u670829\u65e5;3(89):89ra58\u3002<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN178″ module_id=”HGADFN178″ _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN178<\/b><\/h4>\n

\u5bf9 Hutchinson-Gilford \u65e9\u8870\u75c7\u60a3\u8005\u7684\u8f6c\u5f55\u7ec4\u5206\u6790\u63ed\u793a\u4e86\u65e9\u8870\u86cb\u767d\u7684\u4e3b\u8981\u9776\u901a\u8def<\/a>
Vidak S\u3001Kim S\u3001Misteli T. \u9884\u5370\u672c\u3002\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125\u3002\u53d1\u8868\u4e8e2025\u5e749\u670820\u65e5\u3002doi:10.1101\/2025.09.18.677125<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d miR-145 \u548c miR-27b \u5931\u8c03\uff1a\u5bf9\u8102\u80aa\u751f\u6210\u7684\u5f71\u54cd<\/a>
Fenzl FQ\u3001Lederer EM\u3001Brumma L \u7b49\u3002 \u8001\u9f84\u5316\uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09<\/em>. 2025\u5e748\u670827\u65e5\u5728\u7ebf\u53d1\u8868\u3002doi:10.18632\/aging.206309<\/p>\n

miR-181a\u5bf9\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u60a3\u8005SIRT1\u8868\u8fbe\u548c\u8870\u8001\u7684\u5f71\u54cd<\/a>
Lederer EM\u3001Fenzl FQ\u3001Kr\u00fcger P\u3001Schroll M\u3001Hartinger R\u3001Djabali K. \u75be\u75c5<\/em>. 2025;13(8):245. \u53d1\u8868\u4e8e2025\u5e748\u67084\u65e5\u3002doi:10.3390\/diseases13080245<\/p>\n

\u795e\u7ecf\u6cbb\u7597\u80bd\u6cbb\u7597\u53ef\u964d\u4f4e\u4eba\u7c7b\u76ae\u80a4\u6a21\u578b\u4e2d\u7684\u751f\u7269\u5e74\u9f84\u548c\u8870\u8001\u8d1f\u62c5<\/a>
Zonari A\u3001Brace LE\u3001Al-Katib K \u7b49\u4eba\u3002 2024 \u5e74 2 \u6708 15 \u65e5\uff1b10(1):14]\u3002\u00a0NPJ \u8001\u5316<\/em>. 2023;9(1):10\u30022023 \u5e74 5 \u6708 22 \u65e5\u53d1\u5e03\u3002doi:10.1038\/s41514-023-00109-1<\/p>\n

\u901a\u8fc7\u5185\u6838\u819c\u86cb\u767d SUN2 \u6fc0\u6d3b\u5185\u8d28\u7f51\u5e94\u6fc0\u5bfc\u81f4\u8fc7\u65e9\u8870\u8001<\/a>
Vidak S\u3001Serebryannyy LA\u3001Pegoraro G\u3001Misteli T.\u00a0\u624b\u673a\u4ee3\u8868<\/em>\u3002 2023\uff1b42(5)\uff1a112534\u3002 doi:10.1016\/j.celrep.2023.112534<\/p>\n

\u5df4\u745e\u66ff\u5c3c\u548c FTI \u8054\u5408\u6cbb\u7597\u5bf9\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u5176\u4ed6\u8102\u80aa\u8425\u517b\u4e0d\u826f\u6838\u7ea4\u5c42\u86cb\u767d\u75c5\u60a3\u8005\u8102\u80aa\u751f\u6210\u7684\u5f71\u54cd<\/a>
Hartinger R\u3001Lederer EM\u3001Schena E\u3001Lattanzi G\u3001Djabali K. \u7ec6\u80de\u3002 2023\uff1b12(10):1350\u3002\u53d1\u5e03\u4e8e 2023 \u5e74 5 \u6708 9 \u65e5\u3002doi:10.3390\/cells12101350<\/p>\n

hTERT \u6c38\u751f\u5316 Hutchinson-Gilford \u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u7cfb\u7684\u5efa\u7acb\u548c\u9274\u5b9a<\/a>
Lin H\u3001Mensch J\u3001Haschke M \u7b49\u4eba\u3002Cells\u30022022\uff1b11(18)\uff1a2784\u30022022 \u5e74 9 \u6708 6 \u65e5\u53d1\u5e03\u3002doi:10.3390\/cells11182784<\/p>\n

\u901a\u8fc7\u8d28\u8c31\u6cd5\u5bf9\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u60a3\u8005\u7ec6\u80de\u4e2d\u7684\u6cd5\u5462\u57fa\u5316\u65e9\u8870\u86cb\u767d\u8fdb\u884c\u5b9a\u91cf\u5206\u6790<\/a>
Camafeita E\u3001Jorge I\u3001Rivera-Torres J\u3001Andr\u00e9s V\u3001V\u00e1zquez J\u3002 Int J Mol Sci\u3002 2022\uff1b23(19):11733\u3002\u53d1\u5e03\u4e8e 2022 \u5e74 10 \u6708 3 \u65e5\u3002doi:10.3390\/ijms231911733<\/p>\n

\u901a\u8fc7\u76f8\u5206\u79bb\u5b9e\u73b0\u591a\u7ec4\u5206\u7ebf\u7c92\u4f53\u6838\u82f7\u7684\u81ea\u7ec4\u88c5\u3002
<\/a>Feric M\u3001Demarest TG\u3001Tian J\u3001Croteau DL\u3001Bohr VA\u3001Misteli T\u3002EMBO J\u30022021 \u5e74 3 \u6708 15 \u65e5\uff1b40(6):e107165\u3002doi: 10.15252\/embj.2020107165\u3002\u7535\u5b50\u7248 2021 \u5e74 2 \u6708 23 \u65e5\u3002PMID\uff1a33619770\uff1bPMCID\uff1aPMC7957436\u3002<\/p>\n

\u6838\u5b54\u590d\u5408\u4f53\u5728\u590d\u5236\u8870\u8001\u8fc7\u7a0b\u4e2d\u805a\u96c6\u5728\u6b63\u5e38\u548c\u65e9\u8870\u7ec6\u80de\u7684\u7578\u5f62\u6838\u4e2d\u3002
<\/a>R\u00f6hrl JM\u3001Arnold R\u3001Djabali K. Cells\u30022021 \u5e74 1 \u6708 14 \u65e5\uff1b10(1):153\u3002doi\uff1a10.3390\/cells10010153\u3002PMID\uff1a33466669\uff1bPMCID\uff1aPMC7828780\u3002<\/p>\n

\u4eba\u7c7b\u5e73\u6ed1\u808c\u7ec6\u80de\u548c\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u7684\u76f4\u63a5\u91cd\u7f16\u7a0b\u63ed\u793a\u4e86\u4e0e\u8870\u8001\u548c\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u76f8\u5173\u7684\u7f3a\u9677<\/a>
Bersini S\u3001Schulte R\u3001Huang L\u3001Tsai H\u3001Hetzer MW\u3002 \u57c3\u5229\u592b<\/em>. 2020 \u5e74 9 \u6708 8 \u65e5\uff1b9\uff1ae54383\u3002doi\uff1a10.7554\/eLife.54383\u3002PMID\uff1a32896271\uff1bPMCID\uff1aPMC7478891\u3002<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u5c42\u76f8\u5173\u57df\u7684\u8868\u89c2\u9057\u4f20\u5931\u8c03<\/a>
K\u00f6hler F\u3001Bormann F\u3001Raddatz G \u7b49\u4eba\u3002 \u57fa\u56e0\u7ec4\u533b\u5b66<\/em>. 2020;12(1):46\u30022020 \u5e74 5 \u6708 25 \u65e5\u53d1\u5e03\u3002doi:10.1186\/s13073-020-00749-y<\/p>\n

\u77ac\u65f6\u5f15\u5165\u4eba\u7c7b\u7aef\u7c92\u9176 mRNA \u53ef\u6539\u5584\u65e9\u8870\u7ec6\u80de\u7684\u7279\u5f81<\/a>
\u674eY\uff0c\u5468G\uff0cBruno IG\uff0c\u7b49\u3002 \u8870\u8001\u7ec6\u80de<\/em> 2019\uff1b18(4):e12979\u3002 doi\uff1a10.1111\/acel.12979<\/p>\n

\u6839\u636e\u4eba\u7c7b\u771f\u76ae\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u8f6c\u5f55\u7ec4\u9884\u6d4b\u5e74\u9f84<\/a>
Fleischer JG\u3001Schulte R\u3001Tsai HH \u7b49\u4eba\u3002 \u57fa\u56e0\u7ec4\u751f\u7269\u5b66<\/em> 2018;19(1):221\u30022018 \u5e74 12 \u6708 20 \u65e5\u53d1\u5e03\u3002doi:10.1186\/s13059-018-1599-6<\/p>\n

\u76ae\u80a4\u548c\u8840\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u65f6\u949f\u5e94\u7528\u4e8e\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u79bb\u4f53\u7814\u7a76<\/a>
Horvath S\u3001Oshima J\u3001Martin GM \u7b49\u4eba\u3002 \u8001\u5316<\/em> \uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09\u3002 2018\uff1b10(7):1758-1775\u3002 doi\uff1a10.18632\/aging.101508<\/p>\n

\u65e9\u8001\u86cb\u767d\u5bf9 PCNA \u7684\u9694\u79bb\u4fc3\u8fdb\u4e86\u5c42\u86cb\u767d\u75c5\u76f8\u5173\u65e9\u8001\u7efc\u5408\u5f81\u4e2d\u590d\u5236\u53c9\u7684\u5d29\u6e83\u548c XPA \u7684\u9519\u8bef\u5b9a\u4f4d<\/a>
Hilton BA\u3001Liu J\u3001Cartwright BM<\/p>\n

\u60a3\u6709\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u60a3\u8005\u7684\u5e7c\u7a1a\u6210\u4f53\u5e72\u7ec6\u80de\u5728\u4f53\u5185\u8868\u8fbe\u4f4e\u6c34\u5e73\u7684\u65e9\u8870\u86cb\u767d\u3002
<\/a>Wenzel V\u3001Roedl D\u3001Gabriel D\u3001Gordon LB\u3001Herlyn M\u3001Schneider R\u3001Ring J\u3001Djabali K\u3002
\u751f\u7269\u5b66\u5f00\u653e\u671f\u520a\u3002<\/i>\u00a02012 \u5e74 6 \u6708 15 \u65e5\uff1b1(6):516-26\u3002\u7535\u5b50\u7248 2012 \u5e74 4 \u6708 16 \u65e5\u3002<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN188″ module_id=”HGADFN188″ _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN188<\/strong><\/h4>\n

\u5bf9 Hutchinson-Gilford \u65e9\u8870\u75c7\u60a3\u8005\u7684\u8f6c\u5f55\u7ec4\u5206\u6790\u63ed\u793a\u4e86\u65e9\u8870\u86cb\u767d\u7684\u4e3b\u8981\u9776\u901a\u8def<\/a>
Vidak S\u3001Kim S\u3001Misteli T. \u9884\u5370\u672c\u3002\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125\u3002\u53d1\u8868\u4e8e2025\u5e749\u670820\u65e5\u3002doi:10.1101\/2025.09.18.677125<\/p>\n

miR-181a\u5bf9\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u60a3\u8005SIRT1\u8868\u8fbe\u548c\u8870\u8001\u7684\u5f71\u54cd<\/a>
Lederer EM\u3001Fenzl FQ\u3001Kr\u00fcger P\u3001Schroll M\u3001Hartinger R\u3001Djabali K. \u75be\u75c5<\/em>. 2025;13(8):245. \u53d1\u8868\u4e8e2025\u5e748\u67084\u65e5\u3002doi:10.3390\/diseases13080245<\/p>\n

\u4ea8\u5ef7\u987f\u6c0f\u75c5\u60a3\u8005\u539f\u53d1\u6027\u76ae\u80a4\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u5f02\u5e38\u8fc1\u79fb\u7279\u5f81\u6709\u53ef\u80fd\u5229\u7528\u57fa\u4e8e\u56fe\u50cf\u7684\u673a\u5668\u5b66\u4e60\u5de5\u5177\u63ed\u793a\u75be\u75c5\u8fdb\u5c55<\/a>
Gharaba S\u3001Shalem A\u3001Paz O\u3001Muchtar N\u3001Wolf L\u3001Weil M\u3002 \u8ba1\u7b97\u673a\u751f\u7269\u533b\u5b66<\/em>\u30022024 \u5e74 8 \u6708 2 \u65e5\u5728\u7ebf\u53d1\u8868\u3002doi:10.1016\/j.compbiomed.2024.108970<\/p>\n

\u6270\u52a8\u808c\u52a8\u86cb\u767d\u5e3d\u4f5c\u4e3a\u4ea8\u5ef7\u987f\u6c0f\u75c5\u60a3\u8005\u539f\u53d1\u6027\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u7684\u4e00\u79cd\u65b0\u7684\u4e2a\u6027\u5316\u751f\u7269\u6807\u5fd7\u7269<\/a>
Gharaba S\u3001Paz O\u3001Feld L\u3001Abashidze A\u3001Weinrab M\u3001Muchtar N\u3001Baransi A\u3001Shalem A\u3001Sprecher U\u3001Wolf L\u3001Wolfenson H\u3001Weil M\u3002\u524d\u7ec6\u80de\u5f00\u53d1\u751f\u7269\u5b66\u3002 2023 \u5e74 1 \u6708 18 \u65e5\uff1b11:1013721\u3002 DOI\uff1a10.3389\/fcell.2023.1013721\u3002\u7535\u8bdd\u53f7\u7801\uff1a36743412\uff1b PMCID\uff1aPMC9889876\u3002<\/p>\n

hTERT \u6c38\u751f\u5316 Hutchinson-Gilford \u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u7cfb\u7684\u5efa\u7acb\u548c\u9274\u5b9a<\/a>
Lin H\u3001Mensch J\u3001Haschke M \u7b49\u4eba\u3002Cells\u30022022\uff1b11(18)\uff1a2784\u30022022 \u5e74 9 \u6708 6 \u65e5\u53d1\u5e03\u3002doi:10.3390\/cells11182784<\/p>\n

SerpinE1 \u9a71\u52a8\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u7684\u7ec6\u80de\u81ea\u4e3b\u81f4\u75c5\u4fe1\u53f7<\/a>
Catarinella G\u3001Nicoletti C\u3001Bracaglia A \u7b49\u4eba\u3002\u7ec6\u80de\u6b7b\u4ea1\u75be\u75c5\u3002 2022\uff1b13(8):737\u3002 2022 \u5e74 8 \u6708 26 \u65e5\u53d1\u5e03\u3002doi:10.1038\/s41419-022-05168-y<\/p>\n

\u6838\u5b54\u590d\u5408\u4f53\u5728\u590d\u5236\u8870\u8001\u8fc7\u7a0b\u4e2d\u805a\u96c6\u5728\u6b63\u5e38\u548c\u65e9\u8870\u7ec6\u80de\u7684\u7578\u5f62\u6838\u4e2d\u3002
<\/a>R\u00f6hrl JM\u3001Arnold R\u3001Djabali K. Cells\u30022021 \u5e74 1 \u6708 14 \u65e5\uff1b10(1):153\u3002doi\uff1a10.3390\/cells10010153\u3002PMID\uff1a33466669\uff1bPMCID\uff1aPMC7828780\u3002<\/p>\n

SAMMY-seq \u63ed\u793a\u4e86\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u7efc\u5408\u5f81\u4e2d\u5f02\u67d3\u8272\u8d28\u7684\u65e9\u671f\u6539\u53d8\u548c\u4e8c\u4ef7\u57fa\u56e0\u7684\u5931\u8c03Nat <\/a>
Sebesty\u00e9n E\u3001Marullo F\u3001Lucini F\u3001Petrini C\u3001Bianchi A\u3001Valsoni S\u3001Olivieri I\u3001Antonelli L\u3001Gregoretti F\u3001Oliva G\u3001Ferrari F\u3001Lanzuolo C. Commun\u3002 2020 \u5e74 12 \u6708 8 \u65e5\uff1b11(1):6274\u3002 doi\uff1a10.1038\/s41467-020-20048-9\u3002\u7535\u8bdd\u53f7\u7801\uff1a33293552\uff1b PMCID\uff1aPMC7722762\u3002<\/p>\n

\u4eba\u7c7b\u5e73\u6ed1\u808c\u7ec6\u80de\u548c\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u7684\u76f4\u63a5\u91cd\u7f16\u7a0b\u63ed\u793a\u4e86\u4e0e\u8870\u8001\u548c\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u76f8\u5173\u7684\u7f3a\u9677<\/a>
Bersini S\u3001Schulte R\u3001Huang L\u3001Tsai H\u3001Hetzer MW\u3002 \u57c3\u5229\u592b<\/em>. 2020 \u5e74 9 \u6708 8 \u65e5\uff1b9\uff1ae54383\u3002doi\uff1a10.7554\/eLife.54383\u3002PMID\uff1a32896271\uff1bPMCID\uff1aPMC7478891\u3002<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u5c42\u76f8\u5173\u57df\u7684\u8868\u89c2\u9057\u4f20\u5931\u8c03<\/a>
K\u00f6hler F\u3001Bormann F\u3001Raddatz G \u7b49\u4eba\u3002 \u57fa\u56e0\u7ec4\u533b\u5b66<\/em> 2020;12(1):46\u30022020 \u5e74 5 \u6708 25 \u65e5\u53d1\u5e03\u3002doi:10.1186\/s13073-020-00749-y<\/p>\n

\u4f7f\u7528\u5df4\u745e\u66ff\u5c3c\u6291\u5236 JAK-STAT \u4fe1\u53f7\u4f20\u5bfc\u53ef\u51cf\u5c11\u65e9\u8870\u7ec6\u80de\u7684\u708e\u75c7\u5e76\u6539\u5584\u7ec6\u80de\u7a33\u6001<\/a>
\u5218 C\u3001\u963f\u8bfa\u5fb7 R\u3001\u6069\u91cc\u514b\u65af G\u3001\u8d3e\u5df4\u5229 K. \u5355\u5143\u683c<\/em> 2019\uff1b8(10):1276\u30022019 \u5e74 10 \u6708 18 \u65e5\u53d1\u5e03\u3002doi:10.3390\/cells8101276<\/p>\n

\u4f53\u7ec6\u80de\u7a81\u53d8\u5206\u6790\u786e\u5b9a\u4e86\u539f\u53d1\u6027\u771f\u76ae\u6210\u7ea4\u7ef4\u7ec6\u80de\u4f53\u5916\u8001\u5316\u8fc7\u7a0b\u4e2d\u7684\u9009\u62e9\u8ff9\u8c61<\/a>
Narisu N\u3001Rothwell R\u3001Vrta\u010dnik P \u7b49\u3002 \u8870\u8001\u7ec6\u80de<\/em> 2019\uff1b18(6):e13010\u3002 doi\uff1a10.1111\/acel.13010<\/p>\n

\u6839\u636e\u4eba\u7c7b\u771f\u76ae\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u8f6c\u5f55\u7ec4\u9884\u6d4b\u5e74\u9f84<\/a>
Fleischer JG\u3001Schulte R\u3001Tsai HH \u7b49\u4eba\u3002 \u57fa\u56e0\u7ec4\u751f\u7269\u5b66<\/em> 2018;19(1):221\u30022018 \u5e74 12 \u6708 20 \u65e5\u53d1\u5e03\u3002doi:10.1186\/s13059-018-1599-6<\/p>\n

p53 \u540c\u5de5\u578b\u8c03\u8282\u4eba\u7c7b\u7ec6\u80de\u7684\u8fc7\u65e9\u8870\u8001\u3002
<\/a>von Muhlinen N\u3001Horikawa I\u3001Alam F\u3001Isogaya K\u3001Lissa D\u3001Vojtesek B\u3001Lane DP\u3001Harris CC\u3002
\u81f4\u764c\u57fa\u56e0<\/em>. 2018 \u5e74 2 \u6708 12 \u65e5\u3002doi\uff1a10.1038\/s41388-017-0101-3\u3002[\u7535\u5b50\u7248\u5148\u884c\u5370\u5237]<\/p>\n

\u76ae\u80a4\u548c\u8840\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u65f6\u949f\u5e94\u7528\u4e8e\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u79bb\u4f53\u7814\u7a76<\/a>
Horvath S\u3001Oshima J\u3001Martin GM \u7b49\u4eba\u3002 \u8001\u5316<\/em> \uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09\u3002 2018\uff1b10(7):1758-1775\u3002 doi\uff1a10.18632\/aging.101508<\/p>\n

\u66ff\u7f57\u83ab\u53f8\u90e8\u5206\u633d\u6551\u4e86\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u7ec6\u80de\u8868\u578b\u3002<\/a>
\u52a0\u5e03\u91cc\u57c3\u5c14\u00b7D\u3001\u6208\u767b\u00b7LB\u3001\u8d3e\u5df4\u5229\u00b7K. PLoS\u7efc\u5408<\/em> 2016\uff1b11\uff0812\uff09\uff1ae0168988\u30022016 \u5e74 12 \u6708 29 \u65e5\u53d1\u5e03\u3002doi\uff1a10.1371\/journal.pone.0168988<\/p>\n

\u65e9\u8870\u86cb\u767d\u901a\u8fc7\u6d88\u8017\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u4e2d\u671f\u52a8\u7c92\u7ec6\u80de\u4e2d\u7684 CENP-F \u6765\u635f\u5bb3\u67d3\u8272\u4f53\u7684\u7ef4\u6301<\/a>
\u827e\u65bd V\u3001\u5362 X\u3001\u52a0\u5e03\u91cc\u57c3\u5c14 D\u3001\u8d3e\u5df4\u5229 K. \u80bf\u7624\u9776\u70b9<\/em> 2016;7(17):24700-24718\u3002 doi:10.18632\/oncotarget.8267<\/p>\n

\u841d\u535c\u786b\u7d20\u53ef\u589e\u5f3a\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u7684\u65e9\u8870\u86cb\u767d\u6e05\u9664\u7387\u3002
<\/a>\u52a0\u5e03\u91cc\u57c3\u5c14\u00b7D\u3001\u7f57\u5fb7\u5c14\u00b7D\u3001\u6208\u767b\u00b7LB\u3001\u8d3e\u5df4\u5229\u00b7K.\u00a0\u8870\u8001\u7ec6\u80de<\/i>. 2014\u5e7412\u670816\u65e5\uff1a1-14\u3002<\/p>\n

\u6d88\u8017\u7532\u57fa\u8f6c\u79fb\u9176 Suv39h1 \u53ef\u6539\u5584 DNA \u4fee\u590d\u5e76\u5ef6\u957f\u65e9\u8870\u75c7\u5c0f\u9f20\u6a21\u578b\u7684\u5bff\u547d\u3002
<\/a>\u5218 B\uff0c\u738b Z\uff0c\u5f20 L\uff0cGhosh S\uff0c\u90d1 H\uff0c\u5468 Z\u3002\u00a0\u56fd\u5bb6\u901a\u8baf\u793e<\/i>. 2013;4:1868.<\/p>\n

\u60a3\u6709\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u60a3\u8005\u7684\u5e7c\u7a1a\u6210\u4f53\u5e72\u7ec6\u80de\u5728\u4f53\u5185\u8868\u8fbe\u4f4e\u6c34\u5e73\u7684\u65e9\u8870\u86cb\u767d\u3002
<\/a>Wenzel V\u3001Roedl D\u3001Gabriel D\u3001Gordon LB\u3001Herlyn M\u3001Schneider R\u3001Ring J\u3001Djabali K\u3002
\u751f\u7269\u5b66\u5f00\u653e\u671f\u520a\u3002<\/i>\u00a02012 \u5e74 6 \u6708 15 \u65e5\uff1b1(6):516-26\u3002\u7535\u5b50\u7248 2012 \u5e74 4 \u6708 16 \u65e5\u3002<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u7684\u5c42\u86cb\u767d A-Rb \u4fe1\u53f7\u4f20\u5bfc\u7f3a\u9677\u53ca\u901a\u8fc7\u6cd5\u5462\u57fa\u8f6c\u79fb\u9176\u6291\u5236\u800c\u9006\u8f6c\u3002<\/a>
Marji J\u3001O'Donoghue SI\u3001Mcclintock D\u3001Satagopam VP\u3001Schneider R\u3001Ratner D\u3001Worman HJ\u3001Gordon LB\u3001Djabali K.\u00a0PLoS\u7efc\u5408<\/em>. 2010\u5e746\u670815\u65e5;5(6):e11132.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN271″ module_id=”HGADFN271″ _builder_version=”4.27.5″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN271<\/strong><\/h4>\n

\u6291\u5236\u8870\u8001\u7684\u0394133p53\u03b1\u53ef\u5bf9\u6297\u52a0\u901f\u8870\u8001\u548c\u6b7b\u4ea1<\/a>
Yamada L\u3001Liu H\u3001von Muhlinen N\u3001Harris CC\u3001Horikawa I. \u9884\u5370\u672c\u3002.\u00a0bioRxiv<\/em>. 2026;2025.12.31.697195\u3002\u53d1\u8868\u4e8e2026\u5e741\u670820\u65e5\u3002doi:10.64898\/2025.12.31.697195<\/p>\n

\u5728\u65b0\u578b\u7ec6\u80de\u6a21\u578b\u4e2d\u7b5b\u9009\u7279\u5f02\u6027\u5f3a\u3001\u9ad8\u6548\u7684siRNA\u7528\u4e8e\u6cbb\u7597Hutchinson-Gilford\u65e9\u8870\u7efc\u5408\u5f81<\/a>
Dzianisava V\u3001Piekarowicz K\u3001Machowska M\u3001Rzepecki R. \u5206\u5b50\u6cbb\u7597\u6838\u9178<\/em>. 2025;36(4):102727\u3002\u53d1\u8868\u4e8e2025\u5e7410\u67083\u65e5\u3002doi:10.1016\/j.omtn.2025.102727<\/p>\n

\u5bf9 Hutchinson-Gilford \u65e9\u8870\u75c7\u60a3\u8005\u7684\u8f6c\u5f55\u7ec4\u5206\u6790\u63ed\u793a\u4e86\u65e9\u8870\u86cb\u767d\u7684\u4e3b\u8981\u9776\u901a\u8def<\/a>
Vidak S\u3001Kim S\u3001Misteli T. \u9884\u5370\u672c\u3002\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125\u3002\u53d1\u8868\u4e8e2025\u5e749\u670820\u65e5\u3002doi:10.1101\/2025.09.18.677125<\/p>\n

miR-181a\u5bf9\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u60a3\u8005SIRT1\u8868\u8fbe\u548c\u8870\u8001\u7684\u5f71\u54cd<\/a>
Lederer EM\u3001Fenzl FQ\u3001Kr\u00fcger P\u3001Schroll M\u3001Hartinger R\u3001Djabali K. \u75be\u75c5<\/em>. 2025;13(8):245. \u53d1\u8868\u4e8e2025\u5e748\u67084\u65e5\u3002doi:10.3390\/diseases13080245<\/p>\n

\u836f\u7406\u5b66\u6fc0\u6d3b\u0394133p53\u03b1\u53ef\u51cf\u5c11\u65e9\u8870\u75c7\u60a3\u8005\u6765\u6e90\u7ec6\u80de\u7684\u8870\u8001<\/a>
Joruiz SM\u3001Lissa D\u3001Von Muhlinen N \u7b49\u4eba\u3002\u9884\u5370\u672c\u3002\u00a0bioRxiv<\/em>. 2025;2025.07.28.667224. \u51fa\u7248\u65e5\u671f\uff1a2025\u5e748\u67082\u65e5. doi:10.1101\/2025.07.28.667224<\/p>\n

\u5b9a\u91cf\u9ad8\u901a\u91cf\u7b5b\u9009\u9274\u5b9a\u4e0a\u8c03 p53 \u4e9a\u578b \u0394133p53\u03b1 \u5e76\u6291\u5236\u7ec6\u80de\u8870\u8001\u7684\u5316\u5408\u7269<\/a>
Lissa D\u3001Joruiz SM\u3001Dranchak PK \u7b49\u3002\u00a0ACS\u836f\u7406\u5b66\u4e0e\u8f6c\u5316\u79d1\u5b66<\/em>. 2025;8(7):2061-2074. \u53d1\u8868\u65e5\u671f\uff1a2025\u5e746\u670820\u65e5. doi:10.1021\/acsptsci.5c00186<\/p>\n

\u589e\u5f3a\u7ec6\u80de\u7a33\u6001\uff1a\u9776\u5411\u690d\u7269\u5316\u5408\u7269\u589e\u5f3a\u6b63\u5e38\u548c\u8fc7\u65e9\u8870\u8001\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u7ec6\u80de\u5065\u5eb7\u529f\u80fd<\/a>
\u54c8\u5ef7\u683c R\u3001\u8f9b\u683c K\u3001\u83b1\u5f17\u91cc\u7279 J\u3001\u8d3e\u5df4\u5229 K. \u751f\u7269\u5206\u5b50<\/em>. 2024;14(10):1310\u30022024 \u5e74 10 \u6708 16 \u65e5\u53d1\u5e03\u3002doi:10.3390\/biom14101310<\/p>\n

\u4ea8\u5ef7\u987f\u6c0f\u75c5\u60a3\u8005\u539f\u53d1\u6027\u76ae\u80a4\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u5f02\u5e38\u8fc1\u79fb\u7279\u5f81\u6709\u53ef\u80fd\u5229\u7528\u57fa\u4e8e\u56fe\u50cf\u7684\u673a\u5668\u5b66\u4e60\u5de5\u5177\u63ed\u793a\u75be\u75c5\u8fdb\u5c55<\/a>
Gharaba S\u3001Shalem A\u3001Paz O\u3001Muchtar N\u3001Wolf L\u3001Weil M\u3002 \u8ba1\u7b97\u673a\u751f\u7269\u533b\u5b66<\/em>\u30022024 \u5e74 8 \u6708 2 \u65e5\u5728\u7ebf\u53d1\u8868\u3002doi:10.1016\/j.compbiomed.2024.108970<\/p>\n

\u6270\u52a8\u808c\u52a8\u86cb\u767d\u5e3d\u4f5c\u4e3a\u4ea8\u5ef7\u987f\u6c0f\u75c5\u60a3\u8005\u539f\u53d1\u6027\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u7684\u4e00\u79cd\u65b0\u7684\u4e2a\u6027\u5316\u751f\u7269\u6807\u5fd7\u7269<\/a>
Gharaba S\u3001Paz O\u3001Feld L\u3001Abashidze A\u3001Weinrab M\u3001Muchtar N\u3001Baransi A\u3001Shalem A\u3001Sprecher U\u3001Wolf L\u3001Wolfenson H\u3001Weil M\u3002\u524d\u7ec6\u80de\u5f00\u53d1\u751f\u7269\u5b66\u3002 2023 \u5e74 1 \u6708 18 \u65e5\uff1b11:1013721\u3002 DOI\uff1a10.3389\/fcell.2023.1013721\u3002\u7535\u8bdd\u53f7\u7801\uff1a36743412\uff1b PMCID\uff1aPMC9889876\u3002<\/p>\n

SAMMY-seq \u63ed\u793a\u4e86\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u7efc\u5408\u5f81\u4e2d\u5f02\u67d3\u8272\u8d28\u7684\u65e9\u671f\u6539\u53d8\u548c\u4e8c\u4ef7\u57fa\u56e0\u7684\u5931\u8c03Nat <\/a>
Sebesty\u00e9n E\u3001Marullo F\u3001Lucini F\u3001Petrini C\u3001Bianchi A\u3001Valsoni S\u3001Olivieri I\u3001Antonelli L\u3001Gregoretti F\u3001Oliva G\u3001Ferrari F\u3001Lanzuolo C. Commun\u3002 2020 \u5e74 12 \u6708 8 \u65e5\uff1b11(1):6274\u3002 doi\uff1a10.1038\/s41467-020-20048-9\u3002\u7535\u8bdd\u53f7\u7801\uff1a33293552\uff1b PMCID\uff1aPMC7722762\u3002<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u5c42\u76f8\u5173\u57df\u7684\u8868\u89c2\u9057\u4f20\u5931\u8c03<\/a>
K\u00f6hler F\u3001Bormann F\u3001Raddatz G \u7b49\u4eba\u3002 \u57fa\u56e0\u7ec4\u533b\u5b66<\/em>. 2020;12(1):46\u30022020 \u5e74 5 \u6708 25 \u65e5\u53d1\u5e03\u3002doi:10.1186\/s13073-020-00749-y<\/p>\n

\u77ac\u65f6\u5f15\u5165\u4eba\u7c7b\u7aef\u7c92\u9176 mRNA \u53ef\u6539\u5584\u65e9\u8870\u7ec6\u80de\u7684\u7279\u5f81<\/a>
\u674eY\uff0c\u5468G\uff0cBruno IG\uff0c\u7b49\u3002 \u8870\u8001\u7ec6\u80de<\/em> 2019\uff1b18(4):e12979\u3002 doi\uff1a10.1111\/acel.12979<\/p>\n

\u76ae\u80a4\u548c\u8840\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u65f6\u949f\u5e94\u7528\u4e8e\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u79bb\u4f53\u7814\u7a76<\/a>
Horvath S\u3001Oshima J\u3001Martin GM \u7b49\u4eba\u3002 \u8001\u5316<\/em> \uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09\u3002 2018\uff1b10(7):1758-1775\u3002 doi\uff1a10.18632\/aging.101508<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN367″ module_id=”HGADFN367″ _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN367<\/strong><\/h4>\n

\u5728\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u4e2d\u751f\u6210\u975e\u6574\u5408\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff1a\u4fc3\u8fdb\u8870\u8001\u7814\u7a76<\/a>
Kadiwala J, Shakur R.\u00a0\u8001\u5e74\u533b\u5b66\uff08\u7c73\u5c14\u987f\uff09<\/em>. 2025;8(5):493-498\u30022025\u5e749\u670822\u65e5\u53d1\u8868\u3002doi:10.1002\/agm2.70041<\/p>\n

\u5728\u65b0\u578b\u7ec6\u80de\u6a21\u578b\u4e2d\u7b5b\u9009\u7279\u5f02\u6027\u5f3a\u3001\u9ad8\u6548\u7684siRNA\u7528\u4e8e\u6cbb\u7597Hutchinson-Gilford\u65e9\u8870\u7efc\u5408\u5f81<\/a>
Dzianisava V\u3001Piekarowicz K\u3001Machowska M\u3001Rzepecki R. \u5206\u5b50\u6cbb\u7597\u6838\u9178<\/em>. 2025;36(4):102727\u3002\u53d1\u8868\u4e8e2025\u5e7410\u67083\u65e5\u3002doi:10.1016\/j.omtn.2025.102727<\/p>\n

\u4eba\u7c7bBPIFB4\u57fa\u56e0\u7684\u4e00\u79cd\u4e0e\u957f\u5bff\u76f8\u5173\u7684\u53d8\u5f02\u4f53\u53ef\u9884\u9632\u65e9\u8870\u5c0f\u9f20\u7684\u8212\u5f20\u529f\u80fd\u969c\u788d\u3002<\/a>
\u90b1 Y, Cattaneo M, Maciag A, Puca AA, Madeddu P.\u00a0\u4fe1\u53f7\u8f6c\u5bfc\u9776\u5411\u6cbb\u7597<\/em>2025;10(1):314\u3002\u53d1\u8868\u4e8e2025\u5e749\u670829\u65e5\u3002doi:10.1038\/s41392-025-02416-3<\/p>\n

\u5bf9 Hutchinson-Gilford \u65e9\u8870\u75c7\u60a3\u8005\u7684\u8f6c\u5f55\u7ec4\u5206\u6790\u63ed\u793a\u4e86\u65e9\u8870\u86cb\u767d\u7684\u4e3b\u8981\u9776\u901a\u8def<\/a>
Vidak S\u3001Kim S\u3001Misteli T. \u9884\u5370\u672c\u3002\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125\u3002\u53d1\u8868\u4e8e2025\u5e749\u670820\u65e5\u3002doi:10.1101\/2025.09.18.677125<\/p>\n

NLRP3 \u6291\u5236\u5242 Dapansutrile \u589e\u5f3a\u4e86 lonafarnib \u5bf9\u65e9\u8870\u5c0f\u9f20\u7684\u6cbb\u7597\u4f5c\u7528<\/a>
Muela-Zarzuela I\u3001Suarez-Rivero JM\u3001Boy-Ruiz D \u7b49\u3002 \u8870\u8001\u7ec6\u80de<\/em>\u3002 2024 \u5e74 8 \u6708 27 \u65e5\u5728\u7ebf\u53d1\u5e03\u3002doi:10.1111\/acel.14272<\/p>\n

\u4ea8\u5ef7\u987f\u6c0f\u75c5\u60a3\u8005\u539f\u53d1\u6027\u76ae\u80a4\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u5f02\u5e38\u8fc1\u79fb\u7279\u5f81\u6709\u53ef\u80fd\u5229\u7528\u57fa\u4e8e\u56fe\u50cf\u7684\u673a\u5668\u5b66\u4e60\u5de5\u5177\u63ed\u793a\u75be\u75c5\u8fdb\u5c55<\/a>
Gharaba S\u3001Shalem A\u3001Paz O\u3001Muchtar N\u3001Wolf L\u3001Weil M\u3002 \u8ba1\u7b97\u673a\u751f\u7269\u533b\u5b66<\/em>\u30022024 \u5e74 8 \u6708 2 \u65e5\u5728\u7ebf\u53d1\u8868\u3002doi:10.1016\/j.compbiomed.2024.108970<\/p>\n

\u643a\u5e26 LMNA \u57fa\u56e0\u53d8\u5f02 c.1824 C > T \u7684 Hutchinson-Gilford \u65e9\u8870\u75c7\u60a3\u8005\u5fc3\u808c\u7ec6\u80de\u6a21\u578b<\/a>
Perales S\u3001Sigamani V\u3001Rajasingh S\u3001Czirok A\u3001Rajasingh J. [\u5728\u5370\u5237\u524d\u5728\u7ebf\u53d1\u5e03\uff0c2023 \u5e74 8 \u6708 12 \u65e5]\u3002\u00a0\u7ec6\u80de\u7ec4\u7ec7\u7814\u7a76<\/em>\u3002 2023\uff1b10.1007\/s00441-023-03813-2\u3002 doi:10.1007\/s00441-023-03813-2<\/p>\n

\u6270\u52a8\u808c\u52a8\u86cb\u767d\u5e3d\u4f5c\u4e3a\u4ea8\u5ef7\u987f\u6c0f\u75c5\u60a3\u8005\u539f\u53d1\u6027\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u7684\u4e00\u79cd\u65b0\u7684\u4e2a\u6027\u5316\u751f\u7269\u6807\u5fd7\u7269<\/a>
Gharaba S\u3001Paz O\u3001Feld L\u3001Abashidze A\u3001Weinrab M\u3001Muchtar N\u3001Baransi A\u3001Shalem A\u3001Sprecher U\u3001Wolf L\u3001Wolfenson H\u3001Weil M\u3002\u524d\u7ec6\u80de\u5f00\u53d1\u751f\u7269\u5b66\u3002 2023 \u5e74 1 \u6708 18 \u65e5\uff1b11:1013721\u3002 DOI\uff1a10.3389\/fcell.2023.1013721\u3002\u7535\u8bdd\u53f7\u7801\uff1a36743412\uff1b PMCID\uff1aPMC9889876\u3002<\/p>\n

SerpinE1 \u9a71\u52a8\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u7684\u7ec6\u80de\u81ea\u4e3b\u81f4\u75c5\u4fe1\u53f7<\/a>
Catarinella G\u3001Nicoletti C\u3001Bracaglia A \u7b49\u4eba\u3002\u7ec6\u80de\u6b7b\u4ea1\u75be\u75c5\u3002 2022\uff1b13(8):737\u3002 2022 \u5e74 8 \u6708 26 \u65e5\u53d1\u5e03\u3002doi:10.1038\/s41419-022-05168-y<\/p>\n

\u6291\u5236 NLRP3 \u708e\u75c7\u5c0f\u4f53\u53ef\u5ef6\u957f\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u5c0f\u9f20\u6a21\u578b\u7684\u5bff\u547d<\/a>
Gonz\u00e1lez-Dominguez A\u3001Monta\u00f1ez R\u3001Castej\u00f3n-Vega B \u7b49\u4eba\u3002 [\u5370\u5237\u524d\u5728\u7ebf\u53d1\u5e03\uff0c2021 \u5e74 8 \u6708 27 \u65e5]\u3002\u00a0\u6b27\u6d32\u5206\u5b50\u533b\u5b66\u7ec4\u7ec7<\/em>\u3002 2021\uff1be14012\u3002 doi:10.15252\/emmm.202114012<\/p>\n

\u9488\u5bf9\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u53cd\u4e49\u9776\u5411\u6cbb\u7597\u65b9\u6cd5
<\/a>\u9102\u5c14\u591a\u65af MR\u3001\u5361\u5e03\u62c9\u5c14 WA\u3001\u5854\u74e6\u96f7\u65af UL\u3001\u66f9 K\u3001\u683c\u6c83\u5179\u5fb7\u8bfa\u7ef4\u5947-\u8036\u96f7\u7c73\u5947 J\u3001\u7eb3\u91cc\u82cf N\u3001\u6cfd\u6cd5\u65af PM\u3001\u514b\u9c81\u59c6\u5229 S\u3001\u535a\u5e93 Y\u3001\u6c49\u68ee G\u3001\u7a46\u91cc\u5947 DV\u3001\u79d1\u5c14 R\u3001\u57c3\u514b\u8c6a\u65af MA\u3001\u6208\u767b LB\u3001\u67ef\u6797\u65af FS\u3002\u7eb3\u7279\u533b\u5b66\u3002 2021 \u5e74 3 \u6708\uff1b27(3):536-545\u3002 DOI\uff1a10.1038\/s41591-021-01274-0\u3002 Epub 2021 \u5e74 3 \u6708 11 \u65e5\u3002PMID\uff1a33707773\u3002<\/p>\n

\u4eba\u7c7b\u5e73\u6ed1\u808c\u7ec6\u80de\u548c\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u7684\u76f4\u63a5\u91cd\u7f16\u7a0b\u63ed\u793a\u4e86\u4e0e\u8870\u8001\u548c\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u76f8\u5173\u7684\u7f3a\u9677<\/a>
Bersini S\u3001Schulte R\u3001Huang L\u3001Tsai H\u3001Hetzer MW\u3002 \u57c3\u5229\u592b<\/em>. 2020 \u5e74 9 \u6708 8 \u65e5\uff1b9\uff1ae54383\u3002doi\uff1a10.7554\/eLife.54383\u3002PMID\uff1a32896271\uff1bPMCID\uff1aPMC7478891\u3002<\/p>\n

\u77ac\u65f6\u5f15\u5165\u4eba\u7c7b\u7aef\u7c92\u9176 mRNA \u53ef\u6539\u5584\u65e9\u8870\u7ec6\u80de\u7684\u7279\u5f81<\/a>
\u674eY\uff0c\u5468G\uff0cBruno IG\uff0c\u7b49\u3002 \u8870\u8001\u7ec6\u80de<\/em> 2019\uff1b18(4):e12979\u3002 doi\uff1a10.1111\/acel.12979<\/p>\n

\u6839\u636e\u4eba\u7c7b\u771f\u76ae\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u8f6c\u5f55\u7ec4\u9884\u6d4b\u5e74\u9f84<\/a>
Fleischer JG\u3001Schulte R\u3001Tsai HH \u7b49\u4eba\u3002 \u57fa\u56e0\u7ec4\u751f\u7269\u5b66<\/em> 2018;19(1):221\u30022018 \u5e74 12 \u6708 20 \u65e5\u53d1\u5e03\u3002doi:10.1186\/s13059-018-1599-6<\/p>\n

\u76ae\u80a4\u548c\u8840\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u65f6\u949f\u5e94\u7528\u4e8e\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u79bb\u4f53\u7814\u7a76<\/a>
Horvath S\u3001Oshima J\u3001Martin GM \u7b49\u4eba\u3002 \u8001\u5316<\/em> \uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09\u3002 2018\uff1b10(7):1758-1775\u3002 doi\uff1a10.18632\/aging.101508<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGMDFN368″ module_id=”HGMDFN368″ _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGMDFN368<\/strong><\/h4>\n

\u5728\u65b0\u578b\u7ec6\u80de\u6a21\u578b\u4e2d\u7b5b\u9009\u7279\u5f02\u6027\u5f3a\u3001\u9ad8\u6548\u7684siRNA\u7528\u4e8e\u6cbb\u7597Hutchinson-Gilford\u65e9\u8870\u7efc\u5408\u5f81<\/a>
Dzianisava V\u3001Piekarowicz K\u3001Machowska M\u3001Rzepecki R. \u5206\u5b50\u6cbb\u7597\u6838\u9178<\/em>. 2025;36(4):102727\u3002\u53d1\u8868\u4e8e2025\u5e7410\u67083\u65e5\u3002doi:10.1016\/j.omtn.2025.102727<\/p>\n

\u4eba\u7c7bBPIFB4\u57fa\u56e0\u7684\u4e00\u79cd\u4e0e\u957f\u5bff\u76f8\u5173\u7684\u53d8\u5f02\u4f53\u53ef\u9884\u9632\u65e9\u8870\u5c0f\u9f20\u7684\u8212\u5f20\u529f\u80fd\u969c\u788d\u3002<\/a>
\u90b1 Y, Cattaneo M, Maciag A, Puca AA, Madeddu P.\u00a0\u4fe1\u53f7\u8f6c\u5bfc\u9776\u5411\u6cbb\u7597<\/em>2025;10(1):314\u3002\u53d1\u8868\u4e8e2025\u5e749\u670829\u65e5\u3002doi:10.1038\/s41392-025-02416-3<\/p>\n

\u5bf9 Hutchinson-Gilford \u65e9\u8870\u75c7\u60a3\u8005\u7684\u8f6c\u5f55\u7ec4\u5206\u6790\u63ed\u793a\u4e86\u65e9\u8870\u86cb\u767d\u7684\u4e3b\u8981\u9776\u901a\u8def<\/a>
Vidak S\u3001Kim S\u3001Misteli T. \u9884\u5370\u672c\u3002\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125\u3002\u53d1\u8868\u4e8e2025\u5e749\u670820\u65e5\u3002doi:10.1101\/2025.09.18.677125<\/p>\n

miR-181a\u5bf9\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u60a3\u8005SIRT1\u8868\u8fbe\u548c\u8870\u8001\u7684\u5f71\u54cd<\/a>
Lederer EM\u3001Fenzl FQ\u3001Kr\u00fcger P\u3001Schroll M\u3001Hartinger R\u3001Djabali K. \u75be\u75c5<\/em>. 2025;13(8):245. \u53d1\u8868\u4e8e2025\u5e748\u67084\u65e5\u3002doi:10.3390\/diseases13080245<\/p>\n

\u589e\u5f3a\u7ec6\u80de\u7a33\u6001\uff1a\u9776\u5411\u690d\u7269\u5316\u5408\u7269\u589e\u5f3a\u6b63\u5e38\u548c\u8fc7\u65e9\u8870\u8001\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u7ec6\u80de\u5065\u5eb7\u529f\u80fd<\/a>
\u54c8\u5ef7\u683c R\u3001\u8f9b\u683c K\u3001\u83b1\u5f17\u91cc\u7279 J\u3001\u8d3e\u5df4\u5229 K. \u751f\u7269\u5206\u5b50<\/em>. 2024;14(10):1310\u30022024 \u5e74 10 \u6708 16 \u65e5\u53d1\u5e03\u3002doi:10.3390\/biom14101310<\/p>\n

NLRP3 \u6291\u5236\u5242 Dapansutrile \u589e\u5f3a\u4e86 lonafarnib \u5bf9\u65e9\u8870\u5c0f\u9f20\u7684\u6cbb\u7597\u4f5c\u7528<\/a>
Muela-Zarzuela I\u3001Suarez-Rivero JM\u3001Boy-Ruiz D \u7b49\u3002 \u8870\u8001\u7ec6\u80de<\/em>\u3002 2024 \u5e74 8 \u6708 27 \u65e5\u5728\u7ebf\u53d1\u5e03\u3002doi:10.1111\/acel.14272<\/p>\n

\u643a\u5e26 LMNA \u57fa\u56e0\u53d8\u5f02 c.1824 C > T \u7684 Hutchinson-Gilford \u65e9\u8870\u75c7\u60a3\u8005\u5fc3\u808c\u7ec6\u80de\u6a21\u578b<\/a>
Perales S\u3001Sigamani V\u3001Rajasingh S\u3001Czirok A\u3001Rajasingh J. [\u5728\u5370\u5237\u524d\u5728\u7ebf\u53d1\u5e03\uff0c2023 \u5e74 8 \u6708 12 \u65e5]\u3002\u00a0\u7ec6\u80de\u7ec4\u7ec7\u7814\u7a76<\/em>\u3002 2023\uff1b10.1007\/s00441-023-03813-2\u3002 doi:10.1007\/s00441-023-03813-2<\/p>\n

\u6291\u5236 NLRP3 \u708e\u75c7\u5c0f\u4f53\u53ef\u5ef6\u957f\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u5c0f\u9f20\u6a21\u578b\u7684\u5bff\u547d<\/a>
Gonz\u00e1lez-Dominguez A\u3001Monta\u00f1ez R\u3001Castej\u00f3n-Vega B \u7b49\u4eba\u3002 [\u5370\u5237\u524d\u5728\u7ebf\u53d1\u5e03\uff0c2021 \u5e74 8 \u6708 27 \u65e5]\u3002\u00a0\u6b27\u6d32\u5206\u5b50\u533b\u5b66\u7ec4\u7ec7<\/em>\u3002 2021\uff1be14012\u3002 doi:10.15252\/emmm.202114012<\/p>\n

\u9488\u5bf9\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u53cd\u4e49\u9776\u5411\u6cbb\u7597\u65b9\u6cd5
<\/a>\u9102\u5c14\u591a\u65af MR\u3001\u5361\u5e03\u62c9\u5c14 WA\u3001\u5854\u74e6\u96f7\u65af UL\u3001\u66f9 K\u3001\u683c\u6c83\u5179\u5fb7\u8bfa\u7ef4\u5947-\u8036\u96f7\u7c73\u5947 J\u3001\u7eb3\u91cc\u82cf N\u3001\u6cfd\u6cd5\u65af PM\u3001\u514b\u9c81\u59c6\u5229 S\u3001\u535a\u5e93 Y\u3001\u6c49\u68ee G\u3001\u7a46\u91cc\u5947 DV\u3001\u79d1\u5c14 R\u3001\u57c3\u514b\u8c6a\u65af MA\u3001\u6208\u767b LB\u3001\u67ef\u6797\u65af FS\u3002\u7eb3\u7279\u533b\u5b66\u3002 2021 \u5e74 3 \u6708\uff1b27(3):536-545\u3002 DOI\uff1a10.1038\/s41591-021-01274-0\u3002 Epub 2021 \u5e74 3 \u6708 11 \u65e5\u3002PMID\uff1a33707773\u3002<\/p>\n

\u4eba\u7c7b\u5e73\u6ed1\u808c\u7ec6\u80de\u548c\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u7684\u76f4\u63a5\u91cd\u7f16\u7a0b\u63ed\u793a\u4e86\u4e0e\u8870\u8001\u548c\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u76f8\u5173\u7684\u7f3a\u9677<\/a>
Bersini S\u3001Schulte R\u3001Huang L\u3001Tsai H\u3001Hetzer MW\u3002 \u57c3\u5229\u592b<\/em>. 2020 \u5e74 9 \u6708 8 \u65e5\uff1b9\uff1ae54383\u3002doi\uff1a10.7554\/eLife.54383\u3002PMID\uff1a32896271\uff1bPMCID\uff1aPMC7478891\u3002<\/p>\n

\u77ac\u65f6\u5f15\u5165\u4eba\u7c7b\u7aef\u7c92\u9176 mRNA \u53ef\u6539\u5584\u65e9\u8870\u7ec6\u80de\u7684\u7279\u5f81<\/a>
\u674eY\uff0c\u5468G\uff0cBruno IG\uff0c\u7b49\u3002 \u8870\u8001\u7ec6\u80de<\/em> 2019\uff1b18(4):e12979\u3002 doi\uff1a10.1111\/acel.12979<\/p>\n

\u76ae\u80a4\u548c\u8840\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u65f6\u949f\u5e94\u7528\u4e8e\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u79bb\u4f53\u7814\u7a76<\/a>
Horvath S\u3001Oshima J\u3001Martin GM \u7b49\u4eba\u3002 \u8001\u5316<\/em> \uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09\u3002 2018\uff1b10(7):1758-1775\u3002 doi\uff1a10.18632\/aging.101508<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGFDFN369″ module_id=”HGFDFN369″ _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGFDFN369<\/strong><\/h4>\n

\u4eba\u7c7bBPIFB4\u57fa\u56e0\u7684\u4e00\u79cd\u4e0e\u957f\u5bff\u76f8\u5173\u7684\u53d8\u5f02\u4f53\u53ef\u9884\u9632\u65e9\u8870\u5c0f\u9f20\u7684\u8212\u5f20\u529f\u80fd\u969c\u788d\u3002<\/a>
\u90b1 Y, Cattaneo M, Maciag A, Puca AA, Madeddu P.\u00a0\u4fe1\u53f7\u8f6c\u5bfc\u9776\u5411\u6cbb\u7597<\/em>2025;10(1):314\u3002\u53d1\u8868\u4e8e2025\u5e749\u670829\u65e5\u3002doi:10.1038\/s41392-025-02416-3<\/p>\n

\u5bf9 Hutchinson-Gilford \u65e9\u8870\u75c7\u60a3\u8005\u7684\u8f6c\u5f55\u7ec4\u5206\u6790\u63ed\u793a\u4e86\u65e9\u8870\u86cb\u767d\u7684\u4e3b\u8981\u9776\u901a\u8def<\/a>
Vidak S\u3001Kim S\u3001Misteli T. \u9884\u5370\u672c\u3002\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125\u3002\u53d1\u8868\u4e8e2025\u5e749\u670820\u65e5\u3002doi:10.1101\/2025.09.18.677125<\/p>\n

miR-181a\u5bf9\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u60a3\u8005SIRT1\u8868\u8fbe\u548c\u8870\u8001\u7684\u5f71\u54cd<\/a>
Lederer EM\u3001Fenzl FQ\u3001Kr\u00fcger P\u3001Schroll M\u3001Hartinger R\u3001Djabali K. \u75be\u75c5<\/em>. 2025;13(8):245. \u53d1\u8868\u4e8e2025\u5e748\u67084\u65e5\u3002doi:10.3390\/diseases13080245<\/p>\n

\u589e\u5f3a\u7ec6\u80de\u7a33\u6001\uff1a\u9776\u5411\u690d\u7269\u5316\u5408\u7269\u589e\u5f3a\u6b63\u5e38\u548c\u8fc7\u65e9\u8870\u8001\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u7ec6\u80de\u5065\u5eb7\u529f\u80fd<\/a>
\u54c8\u5ef7\u683c R\u3001\u8f9b\u683c K\u3001\u83b1\u5f17\u91cc\u7279 J\u3001\u8d3e\u5df4\u5229 K. \u751f\u7269\u5206\u5b50<\/em>. 2024;14(10):1310\u30022024 \u5e74 10 \u6708 16 \u65e5\u53d1\u5e03\u3002doi:10.3390\/biom14101310<\/p>\n

\u643a\u5e26 LMNA \u57fa\u56e0\u53d8\u5f02 c.1824 C > T \u7684 Hutchinson-Gilford \u65e9\u8870\u75c7\u60a3\u8005\u5fc3\u808c\u7ec6\u80de\u6a21\u578b<\/a>Perales S\u3001Sigamani V\u3001Rajasingh S\u3001Czirok A\u3001Rajasingh J. [\u5728\u5370\u5237\u524d\u5728\u7ebf\u53d1\u5e03\uff0c2023 \u5e74 8 \u6708 12 \u65e5]\u3002\u00a0\u7ec6\u80de\u7ec4\u7ec7\u7814\u7a76<\/em>\u3002 2023\uff1b10.1007\/s00441-023-03813-2\u3002 doi:10.1007\/s00441-023-03813-2<\/p>\n

\u76ae\u80a4\u548c\u8840\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u65f6\u949f\u5e94\u7528\u4e8e\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u79bb\u4f53\u7814\u7a76<\/a>
Horvath S\u3001Oshima J\u3001Martin GM \u7b49\u4eba\u3002 \u963f\u5409<\/em><\/p>\n

[\/et_pb_text][et_pb_text]admin_label=\u201dHGADFN370\u2033 module_id=\u201dHGADFN370\u2033 _builder_version=\u201d4.16\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

\u54c8\u5c14\u6ee8GADFN370<\/strong><\/h4>\n

\u6838\u7ec6\u80de\u9aa8\u67b6\u8fde\u63a5\u4e0d\u5e73\u8861\u5bfc\u81f4\u65e9\u8870\u548c\u751f\u7406\u8870\u8001\u4e2d\u5e38\u89c1\u7684\u6781\u6027\u7f3a\u9677<\/a>
Chang W\u3001\u738b Y\u3001Luxton GWG\u3001\u00d6stlund C\u3001Worman HJ\u3001Gundersen GG\u3002\u00a0 \u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a<\/em>\u3002 2019\uff1b116(9):3578-3583\u3002 doi:10.1073\/pnas.1809683116<\/p>\n

[\/et_pb_text][et_pb_textadmin_label=\u201dHGMDFN371\u2033module_id=\u201dHGMDFN371\u2033_builder_version=\u201d4.16\u2033custom_margin=\u201d50px||50px||true\u201dz_index_tablet=\u201d500\u2033global_colors_info=\u201d{}\u201d]<\/p>\n

HGMDFN371<\/strong><\/h4>\n

\u6838\u7ec6\u80de\u9aa8\u67b6\u8fde\u63a5\u4e0d\u5e73\u8861\u5bfc\u81f4\u65e9\u8870\u548c\u751f\u7406\u8870\u8001\u4e2d\u5e38\u89c1\u7684\u6781\u6027\u7f3a\u9677<\/a>
Chang W\u3001\u738b Y\u3001Luxton GWG\u3001\u00d6stlund C\u3001Worman HJ\u3001Gundersen GG\u3002\u00a0 \u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a<\/em>\u3002 2019\uff1b116(9):3578-3583\u3002 doi:10.1073\/pnas.1809683116<\/p>\n

[\/et_pb_text][et_pb_text \u7ba1\u7406\u5458\u6807\u7b7e=\u201dHGADFN496\u2033 \u6a21\u5757ID=\u201dHGADFN496\u2033 _builder_version=\u201d4.16\u2033 \u81ea\u5b9a\u4e49\u8fb9\u8ddd=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 \u5168\u5c40\u989c\u8272\u4fe1\u606f=\u201d{}\u201d]<\/p>\n

\u54c8\u5c14\u6ee8GADFN496<\/strong><\/h4>\n

\u9488\u5bf9\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u53cd\u4e49\u9776\u5411\u6cbb\u7597\u65b9\u6cd5
<\/a>\u9102\u5c14\u591a\u65af MR\u3001\u5361\u5e03\u62c9\u5c14 WA\u3001\u5854\u74e6\u96f7\u65af UL\u3001\u66f9 K\u3001\u683c\u6c83\u5179\u5fb7\u8bfa\u7ef4\u5947-\u8036\u96f7\u7c73\u5947 J\u3001\u7eb3\u91cc\u82cf N\u3001\u6cfd\u6cd5\u65af PM\u3001\u514b\u9c81\u59c6\u5229 S\u3001\u535a\u5e93 Y\u3001\u6c49\u68ee G\u3001\u7a46\u91cc\u5947 DV\u3001\u79d1\u5c14 R\u3001\u57c3\u514b\u8c6a\u65af MA\u3001\u6208\u767b LB\u3001\u67ef\u6797\u65af FS\u3002\u7eb3\u7279\u533b\u5b66\u3002 2021 \u5e74 3 \u6708\uff1b27(3):536-545\u3002 DOI\uff1a10.1038\/s41591-021-01274-0\u3002 Epub 2021 \u5e74 3 \u6708 11 \u65e5\u3002PMID\uff1a33707773\u3002<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGMDFN717″ module_id=”HGMDFN717″ _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGMDFN717<\/strong><\/h4>\n

\u4eba\u7c7bBPIFB4\u57fa\u56e0\u7684\u4e00\u79cd\u4e0e\u957f\u5bff\u76f8\u5173\u7684\u53d8\u5f02\u4f53\u53ef\u9884\u9632\u65e9\u8870\u5c0f\u9f20\u7684\u8212\u5f20\u529f\u80fd\u969c\u788d\u3002<\/a>
\u90b1 Y, Cattaneo M, Maciag A, Puca AA, Madeddu P.\u00a0\u4fe1\u53f7\u8f6c\u5bfc\u9776\u5411\u6cbb\u7597<\/em>2025;10(1):314\u3002\u53d1\u8868\u4e8e2025\u5e749\u670829\u65e5\u3002doi:10.1038\/s41392-025-02416-3<\/p>\n

\u5bf9 Hutchinson-Gilford \u65e9\u8870\u75c7\u60a3\u8005\u7684\u8f6c\u5f55\u7ec4\u5206\u6790\u63ed\u793a\u4e86\u65e9\u8870\u86cb\u767d\u7684\u4e3b\u8981\u9776\u901a\u8def<\/a>
Vidak S\u3001Kim S\u3001Misteli T. \u9884\u5370\u672c\u3002\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125\u3002\u53d1\u8868\u4e8e2025\u5e749\u670820\u65e5\u3002doi:10.1101\/2025.09.18.677125<\/p>\n

\u643a\u5e26 LMNA \u57fa\u56e0\u53d8\u5f02 c.1824 C > T \u7684 Hutchinson-Gilford \u65e9\u8870\u75c7\u60a3\u8005\u5fc3\u808c\u7ec6\u80de\u6a21\u578b<\/a>
Perales S\u3001Sigamani V\u3001Rajasingh S\u3001Czirok A\u3001Rajasingh J. [\u5728\u5370\u5237\u524d\u5728\u7ebf\u53d1\u5e03\uff0c2023 \u5e74 8 \u6708 12 \u65e5]\u3002 \u7ec6\u80de\u7ec4\u7ec7\u7814\u7a76<\/em>\u3002 2023\uff1b10.1007\/s00441-023-03813-2\u3002 doi:10.1007\/s00441-023-03813-2<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGMDFN718″ module_id=”HGMDFN718″ _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGMDFN718<\/strong><\/h4>\n

\u4eba\u7c7bBPIFB4\u57fa\u56e0\u7684\u4e00\u79cd\u4e0e\u957f\u5bff\u76f8\u5173\u7684\u53d8\u5f02\u4f53\u53ef\u9884\u9632\u65e9\u8870\u5c0f\u9f20\u7684\u8212\u5f20\u529f\u80fd\u969c\u788d\u3002<\/a>
\u90b1 Y, Cattaneo M, Maciag A, Puca AA, Madeddu P.\u00a0\u4fe1\u53f7\u8f6c\u5bfc\u9776\u5411\u6cbb\u7597<\/em>2025;10(1):314\u3002\u53d1\u8868\u4e8e2025\u5e749\u670829\u65e5\u3002doi:10.1038\/s41392-025-02416-3<\/p>\n

\u5bf9 Hutchinson-Gilford \u65e9\u8870\u75c7\u60a3\u8005\u7684\u8f6c\u5f55\u7ec4\u5206\u6790\u63ed\u793a\u4e86\u65e9\u8870\u86cb\u767d\u7684\u4e3b\u8981\u9776\u901a\u8def<\/a>
Vidak S\u3001Kim S\u3001Misteli T. \u9884\u5370\u672c\u3002\u00a0bioRxiv<\/em>. 2025;2025.09.18.677125\u3002\u53d1\u8868\u4e8e2025\u5e749\u670820\u65e5\u3002doi:10.1101\/2025.09.18.677125<\/p>\n

\u9488\u5bf9\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u53cd\u4e49\u9776\u5411\u6cbb\u7597\u65b9\u6cd5
<\/a>\u9102\u5c14\u591a\u65af MR\u3001\u5361\u5e03\u62c9\u5c14 WA\u3001\u5854\u74e6\u96f7\u65af UL\u3001\u66f9 K\u3001\u683c\u6c83\u5179\u5fb7\u8bfa\u7ef4\u5947-\u8036\u96f7\u7c73\u5947 J\u3001\u7eb3\u91cc\u82cf N\u3001\u6cfd\u6cd5\u65af PM\u3001\u514b\u9c81\u59c6\u5229 S\u3001\u535a\u5e93 Y\u3001\u6c49\u68ee G\u3001\u7a46\u91cc\u5947 DV\u3001\u79d1\u5c14 R\u3001\u57c3\u514b\u8c6a\u65af MA\u3001\u6208\u767b LB\u3001\u67ef\u6797\u65af FS\u3002\u7eb3\u7279\u533b\u5b66\u3002 2021 \u5e74 3 \u6708\uff1b27(3):536-545\u3002 DOI\uff1a10.1038\/s41591-021-01274-0\u3002 Epub 2021 \u5e74 3 \u6708 11 \u65e5\u3002PMID\uff1a33707773\u3002<\/p>\n

[\/et_pb_text][et_pb_textadmin_label=\u201dPSADFN086\u2033module_id=\u201dPSADFN086\u2033_builder_version=\u201d4.16\u2033custom_margin=\u201d50px||50px||true\u201dz_index_tablet=\u201d500\u2033global_colors_info=\u201d{}\u201d]<\/p>\n

\u578b\u53f7\uff1aPSADFN086
<\/strong>\uff08\u6b63\u5f0f\u540d\u79f0\u4e3a HGADFN086\uff09<\/u><\/h4>\n

\u00a0<\/strong>\u76ae\u80a4\u548c\u8840\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u65f6\u949f\u5e94\u7528\u4e8e\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u79bb\u4f53\u7814\u7a76<\/a>
Horvath S\u3001Oshima J\u3001Martin GM \u7b49\u4eba\u3002 \u8001\u5316<\/em> \uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09\u3002<\/p>\n

\u4e0e\u4e0d\u5bfb\u5e38\u7684 LMNA \u7a81\u53d8\u76f8\u5173\u7684\u65e9\u8870\u86cb\u767d\u8868\u8fbe\u589e\u52a0\u4f1a\u5bfc\u81f4\u4e25\u91cd\u7684\u65e9\u8870\u7efc\u5408\u5f81\u3002<\/a>
Moulson CL\u3001Fong LG\u3001Gardner JM\u3001Farber EA\u3001Go G\u3001Passariello A\u3001Grange DK\u3001Young SG\u3001Miner JH\u3002\u00a0\u55e1\u55e1\u55e1\u3002<\/em>\u00a02007\u5e749\u6708;28(9):882-9.<\/p>\n

[\/et_pb_text][et_pb_text]admin_label=\u201dPSADFN257\u2033 module_id=\u201dPSADFN257\u2033 _builder_version=\u201d4.16\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

\u578b\u53f7\uff1aPSADFN257<\/strong><\/h4>\n

\u7ec6\u80de\u5185\u5728\u5e72\u6270\u7d20\u6837\u53cd\u5e94\u5c06\u590d\u5236\u538b\u529b\u4e0e\u65e9\u8870\u7d20\u5f15\u8d77\u7684\u7ec6\u80de\u8870\u8001\u8054\u7cfb\u8d77\u6765\u3002
<\/a>Kreienkamp R\u3001Graziano S\u3001Coll-Bonfill N\u3001Bedia-Diaz G\u3001Cybulla E\u3001Vindigni A\u3001Dorsett D\u3001Kubben N\u3001Batista LFZ\u3001Gonzalo S\u3002\u00a0\u624b\u673a\u4ee3\u8868<\/em>. 2018\u5e742\u670820\u65e5;22(8):2006-2015.<\/p>\n

\u76ae\u80a4\u548c\u8840\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u65f6\u949f\u5e94\u7528\u4e8e\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u79bb\u4f53\u7814\u7a76<\/a>
Horvath S\u3001Oshima J\u3001Martin GM \u7b49\u4eba\u3002 \u8001\u5316<\/em> \uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09\u3002 2018\uff1b10(7):1758-1775\u3002 doi\uff1a10.18632\/aging.101508<\/p>\n

\u7ef4\u751f\u7d20 D \u53d7\u4f53\u4fe1\u53f7\u6539\u5584\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7ec6\u80de\u8868\u578b<\/a>
Kreienkamp R\u3001Croke M\u3001Neumann MA \u7b49\u3002 \u80bf\u7624\u9776\u70b9<\/em> 2016;7(21):30018-30031\u3002 doi:10.18632\/oncotarget.9065<\/p>\n

[\/et_pb_text][et_pb_text]admin_label=\u201dPSADFN317\u2033 module_id=\u201dPSADFN317\u2033 _builder_version=\u201d4.21.0\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

psadfn317<\/strong><\/h4>\n

\u5df4\u745e\u66ff\u5c3c\u548c FTI \u8054\u5408\u6cbb\u7597\u5bf9\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u5176\u4ed6\u8102\u80aa\u8425\u517b\u4e0d\u826f\u6838\u7ea4\u5c42\u86cb\u767d\u75c5\u60a3\u8005\u8102\u80aa\u751f\u6210\u7684\u5f71\u54cd<\/a>
Hartinger R\u3001Lederer EM\u3001Schena E\u3001Lattanzi G\u3001Djabali K. \u7ec6\u80de\u3002 2023\uff1b12(10):1350\u3002\u53d1\u5e03\u4e8e 2023 \u5e74 5 \u6708 9 \u65e5\u3002doi:10.3390\/cells12101350<\/p>\n

\u76ae\u80a4\u548c\u8840\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u65f6\u949f\u5e94\u7528\u4e8e\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u79bb\u4f53\u7814\u7a76<\/a>
Horvath S\u3001Oshima J\u3001Martin GM \u7b49\u4eba\u3002 \u8001\u5316<\/em> \uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09\u3002 2018\uff1b10(7):1758-1775\u3002 doi\uff1a10.18632\/aging.101508<\/p>\n

[\/et_pb_text][et_pb_text]admin_label=\u201dPSADFN318\u2033 module_id=\u201dPSADFN318\u2033 _builder_version=\u201d4.21.0\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

\u578b\u53f7\uff1aPSADFN318<\/strong><\/h4>\n

\u5df4\u745e\u66ff\u5c3c\u548c FTI \u8054\u5408\u6cbb\u7597\u5bf9\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u5176\u4ed6\u8102\u80aa\u8425\u517b\u4e0d\u826f\u6838\u7ea4\u5c42\u86cb\u767d\u75c5\u60a3\u8005\u8102\u80aa\u751f\u6210\u7684\u5f71\u54cd<\/a>
Hartinger R\u3001Lederer EM\u3001Schena E\u3001Lattanzi G\u3001Djabali K. \u7ec6\u80de\u3002 2023\uff1b12(10):1350\u3002\u53d1\u5e03\u4e8e 2023 \u5e74 5 \u6708 9 \u65e5\u3002doi:10.3390\/cells12101350<\/p>\n

\u76ae\u80a4\u548c\u8840\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u65f6\u949f\u5e94\u7528\u4e8e\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u79bb\u4f53\u7814\u7a76<\/a>
Horvath S\u3001Oshima J\u3001Martin GM \u7b49\u4eba\u3002 \u8001\u5316<\/em> \uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09\u3002 2018\uff1b10(7):1758-1775\u3002 doi\uff1a10.18632\/aging.101508<\/p>\n

[\/et_pb_text][et_pb_text]admin_label=\u201dPSFDFN319\u2033 module_id=\u201dPSFDFN319\u2033 _builder_version=\u201d4.16\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

psfdfn319<\/strong><\/h4>\n

\u76ae\u80a4\u548c\u8840\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u65f6\u949f\u5e94\u7528\u4e8e\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u79bb\u4f53\u7814\u7a76<\/a>
Horvath S\u3001Oshima J\u3001Martin GM \u7b49\u4eba\u3002 \u8001\u5316<\/em> \uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09\u3002 2018\uff1b10(7):1758-1775\u3002 doi\uff1a10.18632\/aging.101508<\/p>\n

\u96f7\u5e15\u9709\u7d20\u53ef\u9006\u8f6c\u7ec6\u80de\u8868\u578b\u5e76\u589e\u5f3a\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7ec6\u80de\u4e2d\u7684\u7a81\u53d8\u86cb\u767d\u6e05\u9664\u7387\u3002<\/a>
\u66f9K\uff0c\u683c\u62c9\u9f50\u5965\u6258JJ\uff0c\u5e03\u83b1\u5c14CD\uff0cMazzulli JR\uff0c\u9102\u5c14\u591a\u65afMR\uff0cKrainc D\uff0c\u67ef\u6797\u65afFS\u3002\u00a0\u79d1\u5b66\u7ffb\u8bd1\u533b\u5b66\u3002<\/em>\u00a02011\u5e746\u670829\u65e5;3(89):89ra58\u3002<\/p>\n

[\/et_pb_text][et_pb_text \u7ba1\u7406\u5458\u6807\u7b7e=\u201dPSMDFN320\u2033 \u6a21\u5757ID=\u201dPSMDFN320\u2033 _builder_version=\u201d4.16\u2033 \u81ea\u5b9a\u4e49\u8fb9\u8ddd=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 \u5168\u5c40\u989c\u8272\u4fe1\u606f=\u201d{}\u201d]<\/p>\n

\u666e\u9002\u914d\u5361<\/strong><\/h4>\n

\u76ae\u80a4\u548c\u8840\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u65f6\u949f\u5e94\u7528\u4e8e\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u79bb\u4f53\u7814\u7a76<\/a>
Horvath S\u3001Oshima J\u3001Martin GM\u3001<\/p>\n

\u96f7\u5e15\u9709\u7d20\u53ef\u9006\u8f6c\u7ec6\u80de\u8868\u578b\u5e76\u589e\u5f3a\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7ec6\u80de\u4e2d\u7684\u7a81\u53d8\u86cb\u767d\u6e05\u9664\u7387\u3002<\/a>
\u66f9K\uff0c\u683c\u62c9\u9f50\u5965\u6258JJ\uff0c\u5e03\u83b1\u5c14CD\uff0cMazzulli JR\uff0c\u9102\u5c14\u591a\u65afMR\uff0cKrainc D\uff0c\u67ef\u6797\u65afFS\u3002\u00a0\u79d1\u5b66\u7ffb\u8bd1\u533b\u5b66\u3002<\/em>\u00a02011\u5e746\u670829\u65e5;3(89):89ra58\u3002<\/p>\n

[\/et_pb_text][et_pb_text]admin_label=\u201dPSMDFN326\u2033 module_id=\u201dPSMDFN326\u2033 _builder_version=\u201d4.16\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

PSMDFN326<\/strong><\/h4>\n

\u76ae\u80a4\u548c\u8840\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u65f6\u949f\u5e94\u7528\u4e8e\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u79bb\u4f53\u7814\u7a76<\/a>
Horvath S\u3001Oshima J\u3001Martin GM \u7b49\u4eba\u3002 \u8001\u5316<\/em> \uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09\u3002 2018\uff1b10(7):1758-1775\u3002 doi\uff1a10.18632\/aging.101508<\/p>\n

[\/et_pb_text][et_pb_text]admin_label=\u201dPSFDFN327\u2033 module_id=\u201dPSFDFN327\u2033 _builder_version=\u201d4.16\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

PSDFN327 \u578b<\/strong><\/h4>\n

\u7ec6\u80de\u5185\u5728\u5e72\u6270\u7d20\u6837\u53cd\u5e94\u5c06\u590d\u5236\u538b\u529b\u4e0e\u65e9\u8870\u7d20\u5f15\u8d77\u7684\u7ec6\u80de\u8870\u8001\u8054\u7cfb\u8d77\u6765\u3002
<\/a>Kreienkamp R\u3001Graziano S\u3001Coll-Bonfill N\u3001Bedia-Diaz G\u3001Cybulla E\u3001Vindigni A\u3001Dorsett D\u3001Kubben N\u3001Batista LFZ\u3001Gonzalo S\u3002\u00a0\u624b\u673a\u4ee3\u8868<\/em>. 2018\u5e742\u670820\u65e5;22(8):2006-2015.<\/p>\n

\u76ae\u80a4\u548c\u8840\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u65f6\u949f\u5e94\u7528\u4e8e\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u79bb\u4f53\u7814\u7a76<\/a>
Horvath S\u3001Oshima J\u3001Martin GM \u7b49\u4eba\u3002 \u8001\u5316<\/em> \uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09\u3002 2018\uff1b10(7):1758-1775\u3002 doi\uff1a10.18632\/aging.101508<\/p>\n

\u7ef4\u751f\u7d20 D \u53d7\u4f53\u4fe1\u53f7\u6539\u5584\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7ec6\u80de\u8868\u578b<\/a>
Kreienkamp R\u3001Croke M\u3001Neumann MA \u7b49\u3002 \u80bf\u7624\u9776\u70b9<\/em> 2016;7(21):30018-30031\u3002 doi:10.18632\/oncotarget.9065<\/p>\n

[\/et_pb_text][et_pb_text]admin_label=\u201dPSMDFN346\u2033 module_id=\u201dPSMDFN346\u2033 _builder_version=\u201d4.16\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

PSMDFN346<\/strong><\/h4>\n

\u7ec6\u80de\u5185\u5728\u5e72\u6270\u7d20\u6837\u53cd\u5e94\u5c06\u590d\u5236\u538b\u529b\u4e0e\u65e9\u8870\u7d20\u5f15\u8d77\u7684\u7ec6\u80de\u8870\u8001\u8054\u7cfb\u8d77\u6765\u3002
<\/a>Kreienkamp R\u3001Graziano S\u3001Coll-Bonfill N\u3001Bedia-Diaz G\u3001Cybulla E\u3001Vindigni A\u3001Dorsett D\u3001Kubben N\u3001Batista LFZ\u3001Gonzalo S\u3002\u00a0\u624b\u673a\u4ee3\u8868<\/em>. 2018\u5e742\u670820\u65e5;22(8):2006-2015.<\/p>\n

\u76ae\u80a4\u548c\u8840\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u65f6\u949f\u5e94\u7528\u4e8e\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u79bb\u4f53\u7814\u7a76<\/a>
Horvath S\u3001Oshima J\u3001Martin GM \u7b49\u4eba\u3002 \u8001\u5316<\/em> \uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09\u3002 2018\uff1b10(7):1758-1775\u3002 doi\uff1a10.18632\/aging.101508<\/p>\n

\u7ef4\u751f\u7d20 D \u53d7\u4f53\u4fe1\u53f7\u6539\u5584\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7ec6\u80de\u8868\u578b<\/a>
Kreienkamp R\u3001Croke M\u3001Neumann MA \u7b49\u3002 \u80bf\u7624\u9776\u70b9<\/em> 2016;7(21):30018-30031\u3002 doi:10.18632\/oncotarget.9065<\/p>\n

[\/et_pb_text][et_pb_text]admin_label=\u201dPSADFN363\u2033 module_id=\u201dPSADFN363\u2033 _builder_version=\u201d4.24.3\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

psadfn363 \u578b\u53f7<\/strong><\/h4>\n

\u6cd5\u5462\u57fa\u8f6c\u79fb\u9176\u6291\u5236\u5242 (FTI) lonafarnib \u53ef\u6539\u5584\u65e9\u8870\u75c7 MAD-B \u60a3\u8005 ZMPSTE24 \u7f3a\u9677\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u6838\u5f62\u6001<\/a>
Odinammadu KO\u3001Shilagardi K\u3001Tuminelli K\u3001Judge DP\u3001Gordon LB\u3001Michaelis S. \u6838<\/em>. 2023;14(1):2288476.doi:10.1080\/19491034.2023.2288476<\/p>\n

[\/et_pb_text][et_pb_text]admin_label=\u201dPSADFN373\u2033 module_id=\u201dPSADFN373\u2033 _builder_version=\u201d4.24.3\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

psadfn373<\/strong><\/h4>\n

\u9776\u5411 RAS \u8f6c\u6362\u9176 1 \u53ef\u514b\u670d\u8870\u8001\u5e76\u6539\u5584 ZMPSTE24 \u7f3a\u4e4f\u75c7\u7684\u65e9\u8870\u6837\u8868\u578b<\/a>
\u59da H\u3001\u9648 X\u3001\u5361\u5e0c\u592b M\u3001\u738b T\u3001\u6613\u535c\u62c9\u6b23 MX\u3001\u56fe\u514b\u8428\u6885\u5c14 E\u3001Rev\u00eachon G\u3001\u57c3\u91cc\u514b\u68ee M\u3001\u7ef4\u5c14 C\u3001\u8d1d\u5c14\u6208 MO\u3002\u8001\u5316\u7ec6\u80de\u3002 2020 \u5e74 8 \u6708\uff1b19(8)\uff1ae13200\u3002 doi\uff1a10.1111\/acel.13200\u3002 Epub 2020 \u5e74 7 \u6708 24 \u65e5\u3002PMID\uff1a32910507\uff1b PMCID\uff1aPMC7431821\u3002<\/p>\n

[\/et_pb_text][et_pb_text \u7ba1\u7406\u5458\u6807\u7b7e=\u201dPSADFN392\u2033 \u6a21\u5757ID=\u201dPSADFN392\u2033 _builder\u7248\u672c=\u201d4.24.3\u2033 \u81ea\u5b9a\u4e49\u8fb9\u8ddd=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 \u5168\u5c40\u989c\u8272\u4fe1\u606f=\u201d{}\u201d]<\/p>\n

\u578b\u53f7\uff1aPSADFN392<\/strong><\/h4>\n

\u4e00\u79cd\u65b0\u7684\u4f53\u7ec6\u80de\u7a81\u53d8\u4f7f\u60a3\u6709\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u513f\u7ae5\u83b7\u5f97\u90e8\u5206\u633d\u6551<\/a>
\u5df4\u5c14 DZ\u3001Arlt MF\u3001Brazier JF \u7b49\u4eba\u3002 \u533b\u5b66\u9057\u4f20\u5b66\u6742\u5fd7<\/em>\u3002 2017\uff1b54(3):212-216\u3002 doi:10.1136\/jmedgenet-2016-104295<\/p>\n

\u7ec6\u80de\u5185\u5728\u5e72\u6270\u7d20\u6837\u53cd\u5e94\u5c06\u590d\u5236\u538b\u529b\u4e0e\u65e9\u8870\u7d20\u5f15\u8d77\u7684\u7ec6\u80de\u8870\u8001\u8054\u7cfb\u8d77\u6765\u3002
<\/a>Kreienkamp R\u3001Graziano S\u3001Coll-Bonfill N\u3001Bedia-Diaz G\u3001Cybulla E\u3001Vindigni A\u3001Dorsett D\u3001Kubben N\u3001Batista LFZ\u3001Gonzalo S\u3002\u00a0\u624b\u673a\u4ee3\u8868<\/em>. 2018\u5e742\u670820\u65e5;22(8):2006-2015.<\/p>\n

\u76ae\u80a4\u548c\u8840\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u65f6\u949f\u5e94\u7528\u4e8e\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u79bb\u4f53\u7814\u7a76<\/a>
Horvath S\u3001Oshima J\u3001Martin GM \u7b49\u4eba\u3002 \u8001\u5316<\/em> \uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09\u3002 2018\uff1b10(7):1758-1775\u3002 doi\uff1a10.18632\/aging.101508<\/p>\n

\u7ef4\u751f\u7d20 D \u53d7\u4f53\u4fe1\u53f7\u6539\u5584\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7ec6\u80de\u8868\u578b<\/a>
Kreienkamp R\u3001Croke M\u3001Neumann MA \u7b49\u3002 \u80bf\u7624\u9776\u70b9<\/em> 2016;7(21):30018-30031\u3002 doi:10.18632\/oncotarget.9065<\/p>\n

[\/et_pb_text][et_pb_text]admin_label=\u201dPSADFN423\u2033 module_id=\u201dPSADFN423\u2033 _builder_version=\u201d4.24.3\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

PSADFN423 \u578b<\/strong><\/h4>\n

\u4e00\u79cd\u65b0\u7684\u4f53\u7ec6\u80de\u7a81\u53d8\u4f7f\u60a3\u6709\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u513f\u7ae5\u83b7\u5f97\u90e8\u5206\u633d\u6551<\/a>
\u5df4\u5c14 DZ\u3001Arlt MF\u3001Brazier JF \u7b49\u4eba\u3002 \u533b\u5b66\u9057\u4f20\u5b66\u6742\u5fd7<\/em>\u3002 2017\uff1b54(3):212-216\u3002 doi:10.1136\/jmedgenet-2016-104295<\/p>\n

[\/et_pb_text][et_pb_text]admin_label=\u201dPSADFN485\u2033 module_id=\u201dPSADFN485\u2033 _builder_version=\u201d4.24.3\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

\u578b\u53f7\uff1aPSADFN485<\/h4>\n

\u6cd5\u5462\u57fa\u8f6c\u79fb\u9176\u6291\u5236\u5242 (FTI) lonafarnib \u53ef\u6539\u5584\u65e9\u8870\u75c7 MAD-B \u60a3\u8005 ZMPSTE24 \u7f3a\u9677\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u6838\u5f62\u6001<\/a>
Odinammadu KO\u3001Shilagardi K\u3001Tuminelli K\u3001Judge DP\u3001Gordon LB\u3001Michaelis S. \u6838<\/em>. 2023;14(1):2288476.doi:10.1080\/19491034.2023.2288476<\/p>\n

[\/et_pb_text][et_pb_text]admin_label=\u201dPSADFN542\u2033 module_id=\u201dPSADFN542\u2033 _builder_version=\u201d4.24.3\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

\u578b\u53f7\uff1aPSADFN542<\/h4>\n

\u6cd5\u5462\u57fa\u8f6c\u79fb\u9176\u6291\u5236\u5242 (FTI) lonafarnib \u53ef\u6539\u5584\u65e9\u8870\u75c7 MAD-B \u60a3\u8005 ZMPSTE24 \u7f3a\u9677\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u6838\u5f62\u6001<\/a>
Odinammadu KO\u3001Shilagardi K\u3001Tuminelli K\u3001Judge DP\u3001Gordon LB\u3001Michaelis S. \u6838<\/em>. 2023;14(1):2288476.doi:10.1080\/19491034.2023.2288476<\/p>\n

[\/et_pb_text][et_pb_text]admin_label=\u201dPSADFN386\u2033 module_id=\u201dPSADFN386\u2033 _builder_version=\u201d4.24.3\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

\u578b\u53f7\uff1aPSADFN386<\/strong><\/h4>\n

\u4e00\u79cd\u65b0\u7684\u4f53\u7ec6\u80de\u7a81\u53d8\u4f7f\u60a3\u6709\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u513f\u7ae5\u83b7\u5f97\u90e8\u5206\u633d\u6551<\/a>
\u5df4\u5c14 DZ\u3001Arlt MF\u3001Brazier JF \u7b49\u4eba\u3002 \u533b\u5b66\u9057\u4f20\u5b66\u6742\u5fd7<\/em>\u3002 2017\uff1b54(3):212-216\u3002 doi:10.1136\/jmedgenet-2016-104295<\/p>\n

MG132 \u8bf1\u5bfc\u65e9\u8001\u86cb\u767d\u6e05\u9664\u5e76\u6539\u5584 HGPS \u6837\u60a3\u8005\u7ec6\u80de\u7684\u75be\u75c5\u8868\u578b<\/a>
Harhouri K\u3001Cau P\u3001Casey F \u7b49\u4eba\u3002 \u5355\u5143\u683c<\/em>. 2022;11(4):610\u30022022 \u5e74 2 \u6708 10 \u65e5\u53d1\u5e03\u3002doi:10.3390\/cells11040610<\/p>\n

[\/et_pb_text][et_pb_text \u7ba1\u7406\u5458\u6807\u7b7e=\u201dPSMDFN371\u2033 \u6a21\u5757ID=\u201dPSMDFN371\u2033 _builder\u7248\u672c=\u201d4.24.3\u2033 \u81ea\u5b9a\u4e49\u8fb9\u8ddd=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 \u5168\u5c40\u989c\u8272\u4fe1\u606f=\u201d{}\u201d]<\/p>\n

PSMDFN371<\/strong><\/h4>\n

\u4e00\u79cd\u65b0\u7684\u4f53\u7ec6\u80de\u7a81\u53d8\u4f7f\u60a3\u6709\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u513f\u7ae5\u83b7\u5f97\u90e8\u5206\u633d\u6551<\/a>\u5df4\u5c14 DZ\u3001Arlt MF\u3001Brazier JF \u7b49\u4eba\u3002 \u533b\u5b66\u9057\u4f20\u5b66\u6742\u5fd7<\/em>\u3002 2017\uff1b54(3):212-216\u3002 doi:10.1136\/jmedgenet-2016-104295<\/p>\n

[\/et_pb_text][et_pb_text \u7ba1\u7406\u5458\u6807\u7b7e=\u201dPSMDFN387\u2033 \u6a21\u5757ID=\u201dPSMDFN387\u2033 _builder_version=\u201d4.24.3\u2033 \u81ea\u5b9a\u4e49\u8fb9\u8ddd=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 \u5168\u5c40\u989c\u8272\u4fe1\u606f=\u201d{}\u201d]<\/p>\n

PSMDFN387<\/strong><\/h4>\n

\u4e00\u79cd\u65b0\u7684\u4f53\u7ec6\u80de\u7a81\u53d8\u4f7f\u60a3\u6709\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u513f\u7ae5\u83b7\u5f97\u90e8\u5206\u633d\u6551<\/a>\u5df4\u5c14 DZ\u3001Arlt MF\u3001Brazier JF \u7b49\u4eba\u3002 \u533b\u5b66\u9057\u4f20\u5b66\u6742\u5fd7<\/em>\u3002 2017\uff1b54(3):212-216\u3002 doi:10.1136\/jmedgenet-2016-104295<\/p>\n

[\/et_pb_text][et_pb_text]admin_label=\u201dPSFDFN388\u2033 module_id=\u201dPSFDFN388\u2033 _builder_version=\u201d4.24.3\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

psfdfn388<\/strong><\/h4>\n

\u4e00\u79cd\u65b0\u7684\u4f53\u7ec6\u80de\u7a81\u53d8\u4f7f\u60a3\u6709\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u513f\u7ae5\u83b7\u5f97\u90e8\u5206\u633d\u6551<\/a>\u5df4\u5c14 DZ\u3001Arlt MF\u3001Brazier JF \u7b49\u4eba\u3002 \u533b\u5b66\u9057\u4f20\u5b66\u6742\u5fd7<\/em>\u3002 2017\uff1b54(3):212-216\u3002 doi:10.1136\/jmedgenet-2016-104295<\/p>\n

[\/et_pb_text][et_pb_text]admin_label=\u201dPSMDFN393\u2033 module_id=\u201dPSMDFN393\u2033 _builder_version=\u201d4.24.3\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

PSMDFN393<\/strong><\/h4>\n

\u4e00\u79cd\u65b0\u7684\u4f53\u7ec6\u80de\u7a81\u53d8\u4f7f\u60a3\u6709\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u513f\u7ae5\u83b7\u5f97\u90e8\u5206\u633d\u6551<\/a>\u5df4\u5c14 DZ\u3001Arlt MF\u3001Brazier JF \u7b49\u4eba\u3002 \u533b\u5b66\u9057\u4f20\u5b66\u6742\u5fd7<\/em>\u3002 2017\uff1b54(3):212-216\u3002 doi:10.1136\/jmedgenet-2016-104295<\/p>\n

\u76ae\u80a4\u548c\u8840\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u65f6\u949f\u5e94\u7528\u4e8e\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u79bb\u4f53\u7814\u7a76<\/a>
Horvath S\u3001Oshima J\u3001Martin GM \u7b49\u4eba\u3002 \u8001\u5316<\/em> \uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09\u3002 2018\uff1b10(7):1758-1775\u3002 doi\uff1a10.18632\/aging.101508<\/p>\n

[\/et_pb_text][et_pb_text \u7ba1\u7406\u5458\u6807\u7b7e=\u201dPSFDFN394\u2033 \u6a21\u5757ID=\u201dPSFDFN394\u2033 _builder\u7248\u672c=\u201d4.24.3\u2033 \u81ea\u5b9a\u4e49\u8fb9\u8ddd=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 \u5168\u5c40\u989c\u8272\u4fe1\u606f=\u201d{}\u201d]<\/p>\n

PSDFN394<\/strong><\/h4>\n

\u4e00\u79cd\u65b0\u7684\u4f53\u7ec6\u80de\u7a81\u53d8\u4f7f\u60a3\u6709\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u513f\u7ae5\u83b7\u5f97\u90e8\u5206\u633d\u6551<\/a>
\u5df4\u5c14 DZ\u3001Arlt MF\u3001Brazier JF \u7b49\u4eba\u3002 \u533b\u5b66\u9057\u4f20\u5b66\u6742\u5fd7<\/em>\u3002 2017\uff1b54(3):212-216\u3002 doi:10.1136\/jmedgenet-2016-104295<\/p>\n

\u76ae\u80a4\u548c\u8840\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u65f6\u949f\u5e94\u7528\u4e8e\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u79bb\u4f53\u7814\u7a76<\/a>
Horvath S\u3001Oshima J\u3001Martin GM \u7b49\u4eba\u3002 \u8001\u5316<\/em> \uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09\u3002 2018\uff1b10(7):1758-1775\u3002 doi\uff1a10.18632\/aging.101508<\/p>\n

[\/et_pb_text][et_pb_text]admin_label=\u201dPSADFN414\u2033 module_id=\u201dPSADFN414\u2033 _builder_version=\u201d4.16\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

\u578b\u53f7\uff1aPSADFN414<\/strong><\/h4>\n

\u4f9d\u7ef4\u83ab\u53f8\u53ef\u633d\u6551\u5c42\u86cb\u767d\u75c5\u60a3\u8005\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u7684\u591a\u79cd\u7ec6\u80de\u7f3a\u9677<\/a>
DuBose AJ\u3001Lichtenstein ST\u3001Petrash NM\u3001Erdos MR\u3001Gordon LB\u3001Collins FS [\u5df2\u53d1\u8868\u7684\u66f4\u6b63\u51fa\u73b0\u5728 Proc Natl Acad Sci US A. 2018 \u5e74 4 \u6708 16 \u65e5\uff1b:]\u3002 \u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a<\/em>\u3002 2018\uff1b115(16):4206-4211\u3002 doi\uff1a10.1073\/pnas.1802811115<\/p>\n

[\/et_pb_text][et_pb_text]admin_label=\u201dPSADFN425\u2033 module_id=\u201dPSADFN425\u2033 _builder_version=\u201d4.16\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

\u805a\u82ef\u4e59\u70ef\u78fa\u9178\u94a0<\/strong><\/h4>\n

\u4f9d\u7ef4\u83ab\u53f8\u53ef\u633d\u6551\u5c42\u86cb\u767d\u75c5\u60a3\u8005\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u7684\u591a\u79cd\u7ec6\u80de\u7f3a\u9677<\/a>
DuBose AJ\u3001Lichtenstein ST\u3001Petrash NM\u3001Erdos MR\u3001Gordon LB\u3001Collins FS [\u5df2\u53d1\u8868\u7684\u66f4\u6b63\u51fa\u73b0\u5728 Proc Natl Acad Sci US A. 2018 \u5e74 4 \u6708 16 \u65e5\uff1b:]\u3002<\/p>\n

[\/et_pb_text][et_pb_text]admin_label=\u201dHGADFN003 iPS1B\u201d module_id=\u201dHGADFN003 iPS1B\u201d _builder_version=\u201d4.16\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

HGADFN003 iPS1B<\/strong><\/h4>\n

iPSC \u884d\u751f\u7684\u5185\u76ae\u7ec6\u80de\u5f71\u54cd\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7ec4\u7ec7\u5de5\u7a0b\u8840\u7ba1\u6a21\u578b\u4e2d\u7684\u8840\u7ba1\u529f\u80fd<\/a>
Atchison L\u3001Abutaleb NO\u3001Snyder-Mounts E \u7b49\u4eba\u3002 \u5e72\u7ec6\u80de\u62a5\u544a<\/em> 2020\uff1b14(2):325-337\u3002 doi:10.1016\/j.stemcr.2020.01.005<\/p>\n

\u5728 iPS \u884d\u751f\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u4e2d\uff0c\u95f4\u671f\u65e9\u8001\u86cb\u767d\u7684\u78f7\u9178\u5316\u6c34\u5e73\u4f4e\u4e8e\u5c42\u86cb\u767d A\u3001C\uff0c\u4e14\u673a\u68b0\u654f\u611f\u6027\u8f83\u4f4e<\/a>
Cho S\u3001Abbas A\u3001Irianto J \u7b49\u4eba\u3002 \u6838<\/em> 2018;9(1):230-245.doi:10.1080\/19491034.2018.1460185<\/p>\n

\u91cd\u65b0\u7f16\u7a0b\u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u53ef\u91cd\u5efa\u6b63\u5e38\u7684\u8868\u89c2\u9057\u4f20\u666f\u89c2<\/a>Chen Z\u3001Chang WY\u3001Etheridge A \u7b49\u3002 \u8870\u8001\u7ec6\u80de<\/em> 2017\uff1b16(4):870\u2010887\u3002 doi\uff1a10.1111\/acel.12621<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN003 iPS1C” module_id=”HGADFN003 iPS1C” _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN003 iPS1C<\/strong><\/h4>\n

\u817a\u560c\u5464\u78b1\u57fa\u7f16\u8f91\u633d\u6551\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7ec4\u7ec7\u5de5\u7a0b\u8840\u7ba1\u6a21\u578b\u4e2d\u7684\u81f4\u75c5\u8868\u578b<\/a>
Abutaleb NO\uff0c\u9ad8\u6653\u4e1c\uff0cBedapudi A\uff0c\u7b49\u4eba\u3002\u00a0APL\u751f\u7269\u5de5\u7a0b<\/em>. 2025;9(1):016110\u30022025 \u5e74 2 \u6708 26 \u65e5\u53d1\u5e03\u3002doi:10.1063\/5.0244026<\/p>\n

\u57fa\u4e8e\u65e9\u8870\u75c7\u7684\u8840\u7ba1\u6a21\u578b\u8bc6\u522b\u4e0e\u5fc3\u8840\u7ba1\u8870\u8001\u548c\u75be\u75c5\u76f8\u5173\u7684\u7f51\u7edc<\/a>
Ngubo M\u3001Chen Z\u3001McDonald D \u7b49\u3002\u00a0\u8870\u8001\u7ec6\u80de<\/em>\u3002 2024 \u5e74 4 \u6708 4 \u65e5\u5728\u7ebf\u53d1\u5e03\u3002doi:10.1111\/acel.14150<\/p>\n

iPSC \u884d\u751f\u7684\u5185\u76ae\u7ec6\u80de\u5f71\u54cd\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7ec4\u7ec7\u5de5\u7a0b\u8840\u7ba1\u6a21\u578b\u4e2d\u7684\u8840\u7ba1\u529f\u80fd <\/a>
Atchison L\u3001Abutaleb NO\u3001Snyder-Mounts E \u7b49\u4eba\u3002 \u5e72\u7ec6\u80de\u62a5\u544a<\/em> 2020\uff1b14(2):325-337\u3002 doi:10.1016\/j.stemcr.2020.01.005<\/p>\n

\u91cd\u65b0\u7f16\u7a0b\u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u53ef\u91cd\u5efa\u6b63\u5e38\u7684\u8868\u89c2\u9057\u4f20\u666f\u89c2<\/a>
Chen Z\u3001Chang WY\u3001Etheridge A \u7b49\u3002 \u8870\u8001\u7ec6\u80de<\/em>\u3002 2017\uff1b16(4):870\u2010887\u3002 doi\uff1a10.1111\/acel.12621<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN003 iPS1D” module_id=”HGADFN003 iPS1D” _builder_version=”4.27.5″ custom_margin=”50px||50px||true” hover_enabled=”0″ z_index_tablet=”500″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

HGADFN003 iPS1D<\/strong><\/h4>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u4f1a\u6539\u53d8\u5185\u76ae\u7ec6\u80de\u5bf9\u5c42\u6d41\u526a\u5207\u5e94\u529b\u7684\u9057\u4f20\u53cd\u5e94<\/a>
Kennedy CC\u3001Carter JL\u3001Truskey GA\u3002.\u00a0\u751f\u7406\u5b66\u524d\u6cbf<\/em>. 2026;16:1599339\u3002\u53d1\u8868\u4e8e2026\u5e742\u670824\u65e5\u3002doi:10.3389\/fphys.2025.1599339<\/p>\n

\u817a\u560c\u5464\u78b1\u57fa\u7f16\u8f91\u633d\u6551\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7ec4\u7ec7\u5de5\u7a0b\u8840\u7ba1\u6a21\u578b\u4e2d\u7684\u81f4\u75c5\u8868\u578b<\/a>
Abutaleb NO\uff0c\u9ad8\u6653\u4e1c\uff0cBedapudi A\uff0c\u7b49\u4eba\u3002\u00a0APL\u751f\u7269\u5de5\u7a0b<\/em>. 2025;9(1):016110\u30022025 \u5e74 2 \u6708 26 \u65e5\u53d1\u5e03\u3002doi:10.1063\/5.0244026<\/p>\n

\u6d1b\u7eb3\u6cd5\u5c3c\u548c\u4f9d\u7ef4\u83ab\u53f8\u53ef\u51cf\u8f7b\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81 iPSC \u884d\u751f\u7ec4\u7ec7\u5de5\u7a0b\u8840\u7ba1\u6a21\u578b\u4e2d\u7684\u75c5\u7406\u3002<\/a>
Abutaleb NO\u3001Atchison L\u3001Choi L\u3001Bedapudi A\u3001Shores K\u3001Gete Y\u3001Cao K\u3001Truskey GA\u3002Sci Rep. 2023 \u5e74 3 \u6708 28 \u65e5\uff1b13(1):5032\u3002doi\uff1a10.1038\/s41598-023-32035-3\u3002PMID\uff1a36977745\uff1bPMCID\uff1aPMC10050176\u3002<\/p>\n

iPSC \u884d\u751f\u7684\u5185\u76ae\u7ec6\u80de\u5f71\u54cd\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7ec4\u7ec7\u5de5\u7a0b\u8840\u7ba1\u6a21\u578b\u4e2d\u7684\u8840\u7ba1\u529f\u80fd<\/a>
Atchison L\u3001Abutaleb NO\u3001Snyder-Mounts E \u7b49\u4eba\u3002 \u5e72\u7ec6\u80de\u62a5\u544a<\/em> 2020\uff1b14(2):325-337\u3002 doi:10.1016\/j.stemcr.2020.01.005<\/p>\n

\u4eba\u7c7b\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d iPSC \u884d\u751f\u5185\u76ae\u7ec6\u80de\u7684\u529f\u80fd\u969c\u788d<\/a>
Matrone G\u3001Thandavarayan RA\u3001Walther BK\u3001Meng S\u3001Mojiri A\u3001Cooke JP\u3002 \u7ec6\u80de\u5468\u671f <\/em>2019;18(19):2495-2508.doi:10.1080\/15384101.2019.1651587<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGMDFN090 iPS1B” module_id=”HGMDFN090 iPS1B” _builder_version=”4.27.5″ custom_margin=”50px||50px||true” hover_enabled=”0″ z_index_tablet=”500″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

HGMDFN090 iPS1B<\/strong><\/h4>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u4f1a\u6539\u53d8\u5185\u76ae\u7ec6\u80de\u5bf9\u5c42\u6d41\u526a\u5207\u5e94\u529b\u7684\u9057\u4f20\u53cd\u5e94<\/a>
Kennedy CC\u3001Carter JL\u3001Truskey GA\u3002.\u00a0\u751f\u7406\u5b66\u524d\u6cbf<\/em>. 2026;16:1599339\u3002\u53d1\u8868\u4e8e2026\u5e742\u670824\u65e5\u3002doi:10.3389\/fphys.2025.1599339<\/p>\n

\u4eba\u7c7b\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d iPSC \u884d\u751f\u5185\u76ae\u7ec6\u80de\u7684\u529f\u80fd\u969c\u788d<\/a>
Matrone G\u3001Thandavarayan RA\u3001Walther BK\u3001Meng S\u3001Mojiri A\u3001Cooke JP\u3002 \u7ec6\u80de\u5468\u671f<\/em> 2019;18(19):2495-2508.doi:10.1080\/15384101.2019.1651587<\/p>\n

\u00a0<\/strong>\u91cd\u65b0\u7f16\u7a0b\u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u53ef\u91cd\u5efa\u6b63\u5e38\u7684\u8868\u89c2\u9057\u4f20\u666f\u89c2<\/a>
Chen Z\u3001Chang WY\u3001Etheridge A \u7b49\u3002 \u8870\u8001\u7ec6\u80de<\/em>\u3002 2017\uff1b16(4):870\u2010887\u3002 doi\uff1a10.1111\/acel.12621<\/p>\n

[\/et_pb_text][et_pb_text]admin_label=\u201dHGMDFN090 iPS1C\u201d module_id=\u201dHGMDFN090 iPS1C\u201d _builder_version=\u201d4.24.0\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

HGMDFN090 iPS1C<\/strong><\/h4>\n

\u57fa\u4e8e\u65e9\u8870\u75c7\u7684\u8840\u7ba1\u6a21\u578b\u8bc6\u522b\u4e0e\u5fc3\u8840\u7ba1\u8870\u8001\u548c\u75be\u75c5\u76f8\u5173\u7684\u7f51\u7edc<\/a>
Ngubo M\u3001Chen Z\u3001McDonald D \u7b49\u3002\u00a0\u8870\u8001\u7ec6\u80de<\/em>\u3002 2024 \u5e74 4 \u6708 4 \u65e5\u5728\u7ebf\u53d1\u5e03\u3002doi:10.1111\/acel.14150<\/p>\n

\u4f7f\u7528\u7531\u65e9\u8870\u75c7\u60a3\u8005\u884d\u751f\u7684\u8bf1\u5bfc\u6027\u591a\u80fd\u5e72\u7ec6\u80de\u5206\u5316\u800c\u6765\u7684\u5fc3\u808c\u7ec6\u80de\u5206\u6790\u836f\u7269\u8bf1\u53d1\u7684\u5fc3\u5f8b\u5931\u5e38\u98ce\u9669\u7684\u8870\u8001\u6a21\u578b<\/a>
\u6bcf\u65e5 N\u3001\u57c3\u5c14\u68ee J\u3001\u82e5\u6708 T.\u00a0\u56fd\u9645\u5206\u5b50\u79d1\u5b66\u6742\u5fd7<\/em>. 2023;24(15):11959\u30022023 \u5e74 7 \u6708 26 \u65e5\u53d1\u5e03\u3002doi:10.3390\/ijms241511959<\/p>\n

\u91cd\u65b0\u7f16\u7a0b\u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u53ef\u91cd\u5efa\u6b63\u5e38\u7684\u8868\u89c2\u9057\u4f20\u666f\u89c2<\/a>
Chen Z\u3001Chang WY\u3001Etheridge A \u7b49\u3002 \u8870\u8001\u7ec6\u80de<\/em>\u3002 2017\uff1b16(4):870\u2010887\u3002 doi\uff1a10.1111\/acel.12621<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN167 iPS1J” module_id=”HGADFN167 iPS1J” _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN167 iPS1J<\/strong><\/h4>\n

\u60a3\u8005\u6765\u6e90\u7684\u76ae\u8d28\u7c7b\u5668\u5b98\u63ed\u793a\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u795e\u7ecf\u7956\u7ec6\u80de\u7684\u8870\u8001<\/a>
Jeon S\u3001Park CS\u3001Hong J \u7b49\u4eba\u3002\u00a0\u8870\u8001\u7ec6\u80de<\/em>\u3002 2025 \u5e74 6 \u6708 30 \u65e5\u5728\u7ebf\u53d1\u5e03\u3002doi:10.1111\/acel.70143<\/p>\n

\u4f7f\u7528\u7531\u65e9\u8870\u75c7\u60a3\u8005\u884d\u751f\u7684\u8bf1\u5bfc\u6027\u591a\u80fd\u5e72\u7ec6\u80de\u5206\u5316\u800c\u6765\u7684\u5fc3\u808c\u7ec6\u80de\u5206\u6790\u836f\u7269\u8bf1\u53d1\u7684\u5fc3\u5f8b\u5931\u5e38\u98ce\u9669\u7684\u8870\u8001\u6a21\u578b<\/a>
\u6bcf\u65e5 N\u3001\u57c3\u5c14\u68ee J\u3001\u82e5\u6708 T.\u00a0\u56fd\u9645\u5206\u5b50\u79d1\u5b66\u6742\u5fd7<\/em>. 2023;24(15):11959\u30022023 \u5e74 7 \u6708 26 \u65e5\u53d1\u5e03\u3002doi:10.3390\/ijms241511959<\/p>\n

\u5229\u7528\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u60a3\u8005\u7684\u8bf1\u5bfc\u6027\u591a\u80fd\u5e72\u7ec6\u80de\u6a21\u62df\u5fc3\u810f\u8fc7\u65e9\u8870\u8001<\/a>
Monnerat G\u3001Kasai-Brunswick TH\u3001Asensi KD \u7b49\u4eba\u3002\u5229\u7528\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u60a3\u8005\u7684\u8bf1\u5bfc\u6027\u591a\u80fd\u5e72\u7ec6\u80de\u6a21\u62df\u5fc3\u810f\u8fc7\u65e9\u8870\u8001\u3002\u00a0\u751f\u7406\u5b66\u524d\u6cbf<\/em>. 2022\uff1b13\uff1a1007418\u30022022 \u5e74 11 \u6708 23 \u65e5\u53d1\u5e03\u3002doi\uff1a10.3389\/fphys.2022.1007418<\/p>\n

\u91cd\u65b0\u7f16\u7a0b\u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u53ef\u91cd\u5efa\u6b63\u5e38\u7684\u8868\u89c2\u9057\u4f20\u666f\u89c2<\/a>
Chen Z\u3001Chang WY\u3001Etheridge A \u7b49\u3002 \u8870\u8001\u7ec6\u80de<\/em>\u3002 2017\uff1b16(4):870\u2010887\u3002 doi\uff1a10.1111\/acel.12621<\/p>\n

\u901a\u8fc7\u4e0b\u8c03\u805a\uff08ADP-\u6838\u7cd6\uff09\u805a\u5408\u9176 1 \u6765\u63a7\u5236\u65e9\u8870\u75c7\u4e2d\u5e73\u6ed1\u808c\u7ec6\u80de\u6b7b\u4ea1\u7684\u673a\u5236<\/a>
\u5f20\u8f89, \u718a\u5fd7\u6885, \u66f9\u51ef. \u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a\u3002<\/em> 2014;111(22):E2261-E2270.doi:10.1073\/pnas.1320843111<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGADFN167 iPS1Q” module_id=”HGADFN167 iPS1Q” _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGADFN167 iPS1Q<\/strong><\/h4>\n

\u73af\u72b6RNA\u7aef\u7c92\u9176\u9006\u8f6c\u65e9\u8870\u75c7\u7684\u5185\u76ae\u8870\u8001<\/a>
\u79e6\u6587\uff0c\u5361\u65af\u8482\u7565 KD\uff0c\u674e H\uff0c\u7b49\u3002\u00a0\u8870\u8001\u7ec6\u80de<\/em>. 2025 \u5e74 2 \u6708 23 \u65e5\u5728\u7ebf\u53d1\u8868\u3002doi:10.1111\/acel.70021<\/p>\n

\u65e9\u8870\u75c7\u4e2d\u7684\u8840\u7ba1\u8870\u8001\uff1a\u5185\u76ae\u529f\u80fd\u969c\u788d\u7684\u4f5c\u7528<\/a>
Xu Q\u3001Mojiri A\u3001Boulahouache L\u3001Morales E\u3001Walther BK\u3001Cooke JP\u3002\u6b27\u6d32\u5fc3\u810f\u6742\u5fd7\u30022022\uff1b2(4)\uff1aoeac047\u30022022 \u5e74 7 \u6708 28 \u65e5\u53d1\u5e03\u3002doi\uff1a10.1093\/ehjopen\/oeac047<\/p>\n

\u4eba\u7c7b\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d iPSC \u884d\u751f\u5185\u76ae\u7ec6\u80de\u7684\u529f\u80fd\u969c\u788d<\/a>
Matrone G\u3001Thandavarayan RA\u3001Walther BK\u3001Meng S\u3001Mojiri A\u3001Cooke JP\u3002 \u7ec6\u80de\u5468\u671f<\/em> 2019;18(19):2495-2508.doi:10.1080\/15384101.2019.1651587<\/p>\n

\u91cd\u65b0\u7f16\u7a0b\u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u53ef\u91cd\u5efa\u6b63\u5e38\u7684\u8868\u89c2\u9057\u4f20\u666f\u89c2<\/a>
Chen Z\u3001Chang WY\u3001Etheridge A \u7b49\u3002 \u8870\u8001\u7ec6\u80de<\/em> 2017\uff1b16(4):870\u2010887\u3002 doi\uff1a10.1111\/acel.12621<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGFDFN168 iPS1D2″ module_id=”HGFDFN168 iPS1D2″ _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGFDFN168 iPS1D2<\/strong><\/h4>\n

\u60a3\u8005\u6765\u6e90\u7684\u76ae\u8d28\u7c7b\u5668\u5b98\u63ed\u793a\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u795e\u7ecf\u7956\u7ec6\u80de\u7684\u8870\u8001<\/a>
Jeon S\u3001Park CS\u3001Hong J \u7b49\u4eba\u3002\u00a0\u8870\u8001\u7ec6\u80de<\/em>\u3002 2025 \u5e74 6 \u6708 30 \u65e5\u5728\u7ebf\u53d1\u5e03\u3002doi:10.1111\/acel.70143<\/p>\n

\u817a\u560c\u5464\u78b1\u57fa\u7f16\u8f91\u633d\u6551\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7ec4\u7ec7\u5de5\u7a0b\u8840\u7ba1\u6a21\u578b\u4e2d\u7684\u81f4\u75c5\u8868\u578b<\/a>
Abutaleb NO\uff0c\u9ad8\u6653\u4e1c\uff0cBedapudi A\uff0c\u7b49\u4eba\u3002\u00a0APL\u751f\u7269\u5de5\u7a0b<\/em>. 2025;9(1):016110\u30022025 \u5e74 2 \u6708 26 \u65e5\u53d1\u5e03\u3002doi:10.1063\/5.0244026<\/p>\n

\u91cd\u65b0\u7f16\u7a0b\u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u53ef\u91cd\u5efa\u6b63\u5e38\u7684\u8868\u89c2\u9057\u4f20\u666f\u89c2<\/a>
Chen Z\u3001Chang WY\u3001Etheridge A \u7b49\u3002 \u8870\u8001\u7ec6\u80de<\/em>\u3002 2017\uff1b16(4):870\u2010887\u3002 doi\uff1a10.1111\/acel.12621<\/p>\n

\u00a0<\/strong>\u901a\u8fc7\u4e0b\u8c03\u805a\uff08ADP-\u6838\u7cd6\uff09\u805a\u5408\u9176 1 \u6765\u63a7\u5236\u65e9\u8870\u75c7\u4e2d\u5e73\u6ed1\u808c\u7ec6\u80de\u6b7b\u4ea1\u7684\u673a\u5236<\/a>
\u5f20\u8f89, \u718a\u5fd7\u6885, \u66f9\u51ef. \u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a<\/em> 2014;111(22):E2261-E2270.doi:10.1073\/pnas.1320843111<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”HGFDFN168 iPS1P” module_id=”HGFDFN168 iPS1P” _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

HGFDFN168 iPS1P<\/strong><\/h4>\n

\u73af\u72b6RNA\u7aef\u7c92\u9176\u9006\u8f6c\u65e9\u8870\u75c7\u7684\u5185\u76ae\u8870\u8001<\/a>
\u79e6\u6587\uff0c\u5361\u65af\u8482\u7565 KD\uff0c\u674e H\uff0c\u7b49\u3002\u00a0\u8870\u8001\u7ec6\u80de<\/em>. 2025 \u5e74 2 \u6708 23 \u65e5\u5728\u7ebf\u53d1\u8868\u3002doi:10.1111\/acel.70021<\/p>\n

\u65e9\u8870\u75c7\u4e2d\u7684\u8840\u7ba1\u8870\u8001\uff1a\u5185\u76ae\u529f\u80fd\u969c\u788d\u7684\u4f5c\u7528<\/a>
Xu Q\u3001Mojiri A\u3001Boulahouache L\u3001Morales E\u3001Walther BK\u3001Cooke JP\u3002\u6b27\u6d32\u5fc3\u810f\u6742\u5fd7\u30022022\uff1b2(4)\uff1aoeac047\u30022022 \u5e74 7 \u6708 28 \u65e5\u53d1\u5e03\u3002doi\uff1a10.1093\/ehjopen\/oeac047<\/p>\n

\u4eba\u7c7b\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d iPSC \u884d\u751f\u5185\u76ae\u7ec6\u80de\u7684\u529f\u80fd\u969c\u788d<\/a>
Matrone G\u3001Thandavarayan RA\u3001Walther BK\u3001Meng S\u3001Mojiri A\u3001Cooke JP\u3002 \u7ec6\u80de\u5468\u671f<\/em> 2019;18(19):2495-2508.doi:10.1080\/15384101.2019.1651587<\/p>\n

\u91cd\u65b0\u7f16\u7a0b\u65e9\u8870\u6210\u7ea4\u7ef4\u7ec6\u80de\u53ef\u91cd\u5efa\u6b63\u5e38\u7684\u8868\u89c2\u9057\u4f20\u666f\u89c2<\/a>
Chen Z\u3001Chang WY\u3001Etheridge A \u7b49\u3002 \u8870\u8001\u7ec6\u80de<\/em> 2017\uff1b16(4):870\u2010887\u3002 doi\uff1a10.1111\/acel.12621<\/p>\n

[\/et_pb_text][et_pb_textadmin_label=\u201dHGALBV009\u2033module_id=\u201dHGALBV009\u2033_builder_version=\u201d4.16\u2033custom_margin=\u201d50px||50px||true\u201dz_index_tablet=\u201d500\u2033global_colors_info=\u201d{}\u201d]<\/p>\n

HGALBV009<\/strong><\/h4>\n

\u6291\u5236 NLRP3 \u708e\u75c7\u5c0f\u4f53\u53ef\u5ef6\u957f\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u5c0f\u9f20\u6a21\u578b\u7684\u5bff\u547d<\/a>
Gonz\u00e1lez-Dominguez A\u3001Monta\u00f1ez R\u3001Castej\u00f3n-Vega B \u7b49\u4eba\u3002 [\u5370\u5237\u524d\u5728\u7ebf\u53d1\u5e03\uff0c2021 \u5e74 8 \u6708 27 \u65e5]\u3002\u00a0\u6b27\u6d32\u5206\u5b50\u533b\u5b66\u7ec4\u7ec7<\/em>\u3002 2021\uff1be14012\u3002 doi:10.15252\/emmm.202114012<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u7684\u5e72\u7ec6\u80de\u8017\u7aed\u3002<\/a>
Rosengardten Y\u3001McKenna T\u3001Grochov\u00e1 D\u3001Eriksson M.\u00a0\u8870\u8001\u7ec6\u80de\u3002<\/em>\u00a02011 \u5e74 12 \u6708;10(6):1011-20\u30022011 \u5e74 10 \u6708 11 \u65e5\u7535\u5b50\u7248\u3002<\/p>\n

LMNA \u57fa\u56e0\u7684\u4f4e\u8868\u8fbe\u548c\u9ad8\u8868\u8fbe\u7b49\u4f4d\u57fa\u56e0\uff1a\u5bf9\u5c42\u86cb\u767d\u75c5\u75be\u75c5\u53d1\u5c55\u7684\u5f71\u54cd\u3002<\/a>
\u7f57\u5fb7\u91cc\u683c\u65af S\u3001\u57c3\u91cc\u514b\u68ee M.\u00a0PLoS One\u3002<\/em>\u00a02011;6(9):e25472\u30022011 \u5e74 9 \u6708 29 \u65e5\u7535\u5b50\u7248\u51fa\u7248\u3002<\/p>\n

\u5c42\u86cb\u767d A \u4e2d\u53cd\u590d\u53d1\u751f\u7684\u65b0\u751f\u70b9\u7a81\u53d8\u5bfc\u81f4\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u3002<\/a>
Eriksson M\u3001Brown WT\u3001Gordon LB\u3001Glynn MW\u3001Singer J\u3001Scott L\u3001Erdos MR\u3001Robbins CM\u3001Moses TY\u3001Berglund P\u3001Dutra A\u3001Pak E\u3001Durkin S\u3001Csoka AB\u3001Boehnke M\u3001Glover TW\u3001Collins FS\u3002\u00a0\u81ea\u7136<\/em>. 2003 \u5e74 5 \u6708 15 \u65e5;423(6937):293-8\u30022003 \u5e74 4 \u6708 25 \u65e5\u7535\u5b50\u7248\u3002<\/p>\n

[\/et_pb_text][et_pb_textadmin_label=\u201dHGMLBV010\u2033module_id=\u201dHGMLBV010\u2033_builder_version=\u201d4.16\u2033custom_margin=\u201d50px||50px||true\u201dz_index_tablet=\u201d500\u2033global_colors_info=\u201d{}\u201d]<\/p>\n

HGMLBV010<\/strong><\/h4>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u7684\u5e72\u7ec6\u80de\u8017\u7aed\u3002<\/a>
Rosengardten Y\u3001McKenna T\u3001Grochov\u00e1 D\u3001Eriksson M.\u00a0\u8870\u8001\u7ec6\u80de\u3002<\/em>\u00a02011 \u5e74 12 \u6708;10(6):1011-20\u30022011 \u5e74 10 \u6708 11 \u65e5\u7535\u5b50\u7248\u3002<\/p>\n

\u5c42\u86cb\u767d A \u4e2d\u53cd\u590d\u53d1\u751f\u7684\u65b0\u751f\u70b9\u7a81\u53d8\u5bfc\u81f4\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u3002<\/a>
Eriksson M\u3001Brown WT\u3001Gordon LB\u3001Glynn MW\u3001Singer J\u3001Scott L\u3001Erdos MR\u3001Robbins CM\u3001Moses TY\u3001Berglund P\u3001Dutra A\u3001Pak E\u3001Durkin S\u3001Csoka AB\u3001Boehnke M\u3001Glover TW\u3001Collins FS\u3002\u00a0\u81ea\u7136<\/em>. 2003 \u5e74 5 \u6708 15 \u65e5;423(6937):293-8\u30022003 \u5e74 4 \u6708 25 \u65e5\u7535\u5b50\u7248\u3002<\/p>\n

[\/et_pb_text][et_pb_textadmin_label=\u201dHGALBV011\u2033module_id=\u201dHGALBV011\u2033_builder_version=\u201d4.16\u2033custom_margin=\u201d50px||50px||true\u201dz_index_tablet=\u201d500\u2033global_colors_info=\u201d{}\u201d]<\/p>\n

HGALBV011<\/strong><\/h4>\n

LMNA \u57fa\u56e0\u7684\u4f4e\u8868\u8fbe\u548c\u9ad8\u8868\u8fbe\u7b49\u4f4d\u57fa\u56e0\uff1a\u5bf9\u5c42\u86cb\u767d\u75c5\u75be\u75c5\u53d1\u5c55\u7684\u5f71\u54cd\u3002<\/a>
\u7f57\u5fb7\u91cc\u683c\u65af S\u3001\u57c3\u91cc\u514b\u68ee M.\u00a0\u6ce2\u5170<\/em>oS \u4e00\u3002<\/em>\u00a02011;6(9):e25472\u30022011 \u5e74 9 \u6708 29 \u65e5\u7535\u5b50\u7248\u51fa\u7248\u3002<\/p>\n

\u5c42\u86cb\u767d A \u4e2d\u53cd\u590d\u53d1\u751f\u7684\u65b0\u751f\u70b9\u7a81\u53d8\u5bfc\u81f4\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u3002<\/a>
Eriksson M\u3001Brown WT\u3001Gordon LB\u3001Glynn MW\u3001Singer J\u3001Scott L\u3001Erdos MR\u3001Robbins CM\u3001Moses TY\u3001Berglund P\u3001Dutra A\u3001Pak E\u3001Durkin S\u3001Csoka AB\u3001Boehnke M\u3001Glover TW\u3001Collins FS\u3002\u00a0\u81ea\u7136<\/em>. 2003 \u5e74 5 \u6708 15 \u65e5;423(6937):293-8\u30022003 \u5e74 4 \u6708 25 \u65e5\u7535\u5b50\u7248\u3002<\/p>\n

[\/et_pb_text][et_pb_text]admin_label=\u201dHGMLBV013\u2033 module_id=\u201dHGMLBV013\u2033 _builder_version=\u201d4.16\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

HGMLBV013<\/strong><\/h4>\n

\u5c42\u86cb\u767d A \u4e2d\u53cd\u590d\u53d1\u751f\u7684\u65b0\u751f\u70b9\u7a81\u53d8\u5bfc\u81f4\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u3002<\/a>
Eriksson M\u3001Brown WT\u3001Gordon LB\u3001Glynn MW\u3001Singer J\u3001Scott L\u3001Erdos MR\u3001Robbins CM\u3001Moses TY\u3001Berglund P\u3001Dutra A\u3001Pak E\u3001Durkin S\u3001Csoka AB\u3001Boehnke M\u3001Glover TW\u3001Collins FS\u3002\u00a0\u81ea\u7136<\/em>. 2003 \u5e74 5 \u6708 15 \u65e5;423(6937):293-8\u30022003 \u5e74 4 \u6708 25 \u65e5\u7535\u5b50\u7248\u3002<\/p>\n

[\/et_pb_text][et_pb_text]admin_label=\u201dHGFLBV021\u2033 module_id=\u201dHGFLBV021\u2033 _builder_version=\u201d4.16\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

HGFLBV021<\/strong><\/h4>\n

\u6291\u5236 NLRP3 \u708e\u75c7\u5c0f\u4f53\u53ef\u5ef6\u957f\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u5c0f\u9f20\u6a21\u578b\u7684\u5bff\u547d<\/a>
Gonz\u00e1lez-Dominguez A\u3001Monta\u00f1ez R\u3001Castej\u00f3n-Vega B \u7b49\u4eba\u3002 [\u5370\u5237\u524d\u5728\u7ebf\u53d1\u5e03\uff0c2021 \u5e74 8 \u6708 27 \u65e5]\u3002\u00a0\u6b27\u6d32\u5206\u5b50\u533b\u5b66\u7ec4\u7ec7<\/em>\u3002 2021\uff1be14012\u3002 doi:10.15252\/emmm.202114012<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u7684\u5e72\u7ec6\u80de\u8017\u7aed\u3002<\/a>
Rosengardten Y\u3001McKenna T\u3001Grochov\u00e1 D\u3001Eriksson M.\u00a0\u8870\u8001\u7ec6\u80de\u3002<\/em>\u00a02011 \u5e74 12 \u6708;10(6):1011-20\u30022011 \u5e74 10 \u6708 11 \u65e5\u7535\u5b50\u7248\u3002<\/p>\n

\u5c42\u86cb\u767d A \u4e2d\u53cd\u590d\u53d1\u751f\u7684\u65b0\u751f\u70b9\u7a81\u53d8\u5bfc\u81f4\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u3002<\/a>
Eriksson M\u3001Brown WT\u3001Gordon LB\u3001Glynn MW\u3001Singer J\u3001Scott L\u3001Erdos MR\u3001Robbins CM\u3001Moses TY\u3001Berglund P\u3001Dutra A\u3001Pak E\u3001Durkin S\u3001Csoka AB\u3001Boehnke M\u3001Glover TW\u3001Collins FS\u3002\u00a0\u81ea\u7136<\/em>. 2003 \u5e74 5 \u6708 15 \u65e5;423(6937):293-8\u30022003 \u5e74 4 \u6708 25 \u65e5\u7535\u5b50\u7248\u3002<\/p>\n

[\/et_pb_text][et_pb_textadmin_label=\u201dHGMLBV023\u2033module_id=\u201dHGMLBV023\u2033_builder_version=\u201d4.16\u2033custom_margin=\u201d50px||50px||true\u201dz_index_tablet=\u201d500\u2033global_colors_info=\u201d{}\u201d]<\/p>\n

HGMLBV023<\/strong><\/h4>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u7684\u5e72\u7ec6\u80de\u8017\u7aed\u3002<\/a>
Rosengardten Y\u3001McKenna T\u3001Grochov\u00e1 D\u3001Eriksson M.\u00a0\u8870\u8001\u7ec6\u80de\u3002<\/em>\u00a02011 \u5e74 12 \u6708;10(6):1011-20\u30022011 \u5e74 10 \u6708 11 \u65e5\u7535\u5b50\u7248\u3002<\/p>\n

\u5c42\u86cb\u767d A \u4e2d\u53cd\u590d\u53d1\u751f\u7684\u65b0\u751f\u70b9\u7a81\u53d8\u5bfc\u81f4\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u3002<\/a>
Eriksson M\u3001Brown WT\u3001Gordon LB\u3001Glynn MW\u3001Singer J\u3001Scott L\u3001Erdos MR\u3001Robbins CM\u3001Moses TY\u3001Berglund P\u3001Dutra A\u3001Pak E\u3001Durkin S\u3001Csoka AB\u3001Boehnke M\u3001Glover TW\u3001Collins FS\u3002\u00a0\u81ea\u7136<\/em>. 2003 \u5e74 5 \u6708 15 \u65e5;423(6937):293-8\u30022003 \u5e74 4 \u6708 25 \u65e5\u7535\u5b50\u7248\u3002<\/p>\n

[\/et_pb_text][et_pb_textadmin_label=\u201dHGFLBV031\u2033module_id=\u201dHGFLBV031\u2033_builder_version=\u201d4.16\u2033custom_margin=\u201d50px||50px||true\u201dz_index_tablet=\u201d500\u2033global_colors_info=\u201d{}\u201d]<\/p>\n

HGFLBV031<\/strong><\/h4>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u7684\u5e72\u7ec6\u80de\u8017\u7aed\u3002<\/a>
Rosengardten Y\u3001McKenna T\u3001Grochov\u00e1 D\u3001Eriksson M.\u00a0\u8870\u8001\u7ec6\u80de\u3002<\/em>\u00a02011 \u5e74 12 \u6708;10(6):1011-20\u30022011 \u5e74 10 \u6708 11 \u65e5\u7535\u5b50\u7248\u3002<\/p>\n

\u5c42\u86cb\u767d A \u4e2d\u53cd\u590d\u53d1\u751f\u7684\u65b0\u751f\u70b9\u7a81\u53d8\u5bfc\u81f4\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u3002<\/a>
Eriksson M\u3001Brown WT\u3001Gordon LB\u3001Glynn MW\u3001Singer J\u3001Scott L\u3001Erdos MR\u3001Robbins CM\u3001Moses TY\u3001Berglund P\u3001Dutra A\u3001Pak E\u3001Durkin S\u3001Csoka AB\u3001Boehnke M\u3001Glover TW\u3001Collins FS\u3002\u00a0\u81ea\u7136<\/em>. 2003 \u5e74 5 \u6708 15 \u65e5;423(6937):293-8\u30022003 \u5e74 4 \u6708 25 \u65e5\u7535\u5b50\u7248\u3002<\/p>\n

[\/et_pb_text][et_pb_textadmin_label=\u201dHGFLBV050\u2033module_id=\u201dHGFLBV050\u2033_builder_version=\u201d4.16\u2033custom_margin=\u201d50px||50px||true\u201dz_index_tablet=\u201d500\u2033global_colors_info=\u201d{}\u201d]<\/p>\n

HGFLBV050<\/strong><\/h4>\n

\u5c42\u86cb\u767d A \u4e2d\u53cd\u590d\u53d1\u751f\u7684\u65b0\u751f\u70b9\u7a81\u53d8\u5bfc\u81f4\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u3002<\/a>
Eriksson M\u3001Brown WT\u3001Gordon LB\u3001Glynn MW\u3001Singer J\u3001Scott L\u3001Erdos MR\u3001Robbins CM\u3001Moses TY\u3001Berglund P\u3001Dutra A\u3001Pak E\u3001Durkin S\u3001Csoka AB\u3001Boehnke M\u3001Glover TW\u3001Collins FS\u3002\u00a0\u81ea\u7136<\/em>. 2003 \u5e74 5 \u6708 15 \u65e5;423(6937):293-8\u30022003 \u5e74 4 \u6708 25 \u65e5\u7535\u5b50\u7248\u3002<\/p>\n

[\/et_pb_text][et_pb_textadmin_label=\u201dHGALBV057\u2033module_id=\u201dHGALBV057\u2033_builder_version=\u201d4.16\u2033custom_margin=\u201d50px||50px||true\u201dz_index_tablet=\u201d500\u2033global_colors_info=\u201d{}\u201d]<\/p>\n

HGALBV057<\/strong><\/h4>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u7684\u5e72\u7ec6\u80de\u8017\u7aed\u3002<\/a>
Rosengardten Y\u3001McKenna T\u3001Grochov\u00e1 D\u3001Eriksson M.\u00a0\u8870\u8001\u7ec6\u80de\u3002<\/em>\u00a02011 \u5e74 12 \u6708;10(6):1011-20\u30022011 \u5e74 10 \u6708 11 \u65e5\u7535\u5b50\u7248\u3002<\/p>\n

\u5c42\u86cb\u767d A \u4e2d\u53cd\u590d\u53d1\u751f\u7684\u65b0\u751f\u70b9\u7a81\u53d8\u5bfc\u81f4\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u3002<\/a>
Eriksson M\u3001Brown WT\u3001Gordon LB\u3001Glynn MW\u3001Singer J\u3001Scott L\u3001Erdos MR\u3001Robbins CM\u3001Moses TY\u3001Berglund P\u3001Dutra A\u3001Pak E\u3001Durkin S\u3001Csoka AB\u3001Boehnke M\u3001Glover TW\u3001Collins FS\u3002\u00a0\u81ea\u7136<\/em>. 2003 \u5e74 5 \u6708 15 \u65e5;423(6937):293-8\u30022003 \u5e74 4 \u6708 25 \u65e5\u7535\u5b50\u7248\u3002<\/p>\n

[\/et_pb_text][et_pb_textadmin_label=\u201dHGMLBV058\u2033module_id=\u201dHGMLBV058\u2033_builder_version=\u201d4.16\u2033custom_margin=\u201d50px||50px||true\u201dz_index_tablet=\u201d500\u2033global_colors_info=\u201d{}\u201d]<\/p>\n

HGMLBV058<\/strong><\/h4>\n

\u5c42\u86cb\u767d A \u4e2d\u53cd\u590d\u53d1\u751f\u7684\u65b0\u751f\u70b9\u7a81\u53d8\u5bfc\u81f4\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u3002<\/a>
Eriksson M\u3001Brown WT\u3001Gordon LB\u3001Glynn MW\u3001Singer J\u3001Scott L\u3001Erdos MR\u3001Robbins CM\u3001Moses TY\u3001Berglund P\u3001Dutra A\u3001Pak E\u3001Durkin S\u3001Csoka AB\u3001Boehnke M\u3001Glover TW\u3001Collins FS\u3002\u00a0\u81ea\u7136<\/em>. 2003 \u5e74 5 \u6708 15 \u65e5;423(6937):293-8\u30022003 \u5e74 4 \u6708 25 \u65e5\u7535\u5b50\u7248\u3002<\/p>\n

[\/et_pb_text][et_pb_textadmin_label=\u201dHGSLBV059\u2033module_id=\u201dHGMLBV058\u2033_builder_version=\u201d4.16\u2033custom_margin=\u201d50px||50px||true\u201dz_index_tablet=\u201d500\u2033global_colors_info=\u201d{}\u201d]<\/p>\n

HGSLBV059<\/strong><\/h4>\n

\u5c42\u86cb\u767d A \u4e2d\u53cd\u590d\u53d1\u751f\u7684\u65b0\u751f\u70b9\u7a81\u53d8\u5bfc\u81f4\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u3002<\/a>
Eriksson M\u3001Brown WT\u3001Gordon LB\u3001Glynn MW\u3001Singer J\u3001Scott L\u3001Erdos MR\u3001Robbins CM\u3001Moses TY\u3001Berglund P\u3001Dutra A\u3001Pak E\u3001Durkin S\u3001Csoka AB\u3001Boehnke M\u3001Glover TW\u3001Collins FS\u3002\u00a0\u81ea\u7136<\/em>. 2003 \u5e74 5 \u6708 15 \u65e5;423(6937):293-8\u30022003 \u5e74 4 \u6708 25 \u65e5\u7535\u5b50\u7248\u3002\u00a0<\/strong><\/p>\n

[\/et_pb_text][et_pb_textadmin_label=\u201dHGMLBV066\u2033module_id=\u201dHGMLBV066\u2033_builder_version=\u201d4.16\u2033custom_margin=\u201d50px||50px||true\u201dz_index_tablet=\u201d500\u2033global_colors_info=\u201d{}\u201d]<\/p>\n

HGMLBV066<\/strong><\/h4>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u7684\u5e72\u7ec6\u80de\u8017\u7aed\u3002<\/a>
Rosengardten Y\u3001McKenna T\u3001Grochov\u00e1 D\u3001Eriksson M.\u00a0\u8870\u8001\u7ec6\u80de\u3002<\/em>\u00a02011 \u5e74 12 \u6708;10(6):1011-20\u30022011 \u5e74 10 \u6708 11 \u65e5\u7535\u5b50\u7248\u3002<\/p>\n

\u5c42\u86cb\u767d A \u4e2d\u53cd\u590d\u53d1\u751f\u7684\u65b0\u751f\u70b9\u7a81\u53d8\u5bfc\u81f4\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u3002<\/a>
Eriksson M\u3001Brown WT\u3001Gordon LB\u3001Glynn MW\u3001Singer J\u3001Scott L\u3001Erdos MR\u3001Robbins CM\u3001Moses TY\u3001Berglund P\u3001Dutra A\u3001Pak E\u3001Durkin S\u3001Csoka AB\u3001Boehnke M\u3001Glover TW\u3001Collins FS\u3002\u00a0\u81ea\u7136<\/em>. 2003 \u5e74 5 \u6708 15 \u65e5;423(6937):293-8\u30022003 \u5e74 4 \u6708 25 \u65e5\u7535\u5b50\u7248\u3002<\/p>\n

[\/et_pb_text][et_pb_text]admin_label=\u201dHGFLBV067\u2033 module_id=\u201dHGFLBV067\u2033 _builder_version=\u201d4.16\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

HGFLBV067<\/strong><\/h4>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u7684\u5e72\u7ec6\u80de\u8017\u7aed\u3002<\/a>
Rosengardten Y\u3001McKenna T\u3001Grochov\u00e1 D\u3001Eriksson M.\u00a0\u8870\u8001\u7ec6\u80de\u3002<\/em>\u00a02011 \u5e74 12 \u6708\uff1b10(6):1011-20\u3002doi: 10.1111\/j.1474-9726.2011.00743.x\u3002\u7535\u5b50\u7248 2011 \u5e74 10 \u6708 11 \u65e5\u3002<\/p>\n

\u5c42\u86cb\u767d A \u4e2d\u53cd\u590d\u53d1\u751f\u7684\u65b0\u751f\u70b9\u7a81\u53d8\u5bfc\u81f4\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u3002<\/a>
Eriksson M\u3001Brown WT\u3001Gordon LB\u3001Glynn MW\u3001Singer J\u3001Scott L\u3001Erdos MR\u3001Robbins CM\u3001Moses TY\u3001Berglund P\u3001Dutra A\u3001Pak E\u3001Durkin S\u3001Csoka AB\u3001Boehnke M\u3001Glover TW\u3001Collins FS\u3002\u00a0\u81ea\u7136<\/em>. 2003 \u5e74 5 \u6708 15 \u65e5;423(6937):293-8\u30022003 \u5e74 4 \u6708 25 \u65e5\u7535\u5b50\u7248\u3002<\/p>\n

[\/et_pb_text][et_pb_text]admin_label=\u201dHGALBV071\u2033 module_id=\u201dHGALBV071\u2033 _builder_version=\u201d4.16\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

HGALBV071<\/strong><\/h4>\n

\u5c42\u86cb\u767d A \u4e2d\u53cd\u590d\u53d1\u751f\u7684\u65b0\u751f\u70b9\u7a81\u53d8\u5bfc\u81f4\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u3002<\/a>
Eriksson M\u3001Brown WT\u3001Gordon LB\u3001Glynn MW\u3001Singer J\u3001Scott L\u3001Erdos MR\u3001Robbins CM\u3001Moses TY\u3001Berglund P\u3001Dutra A\u3001Pak E\u3001Durkin S\u3001Csoka AB\u3001Boehnke M\u3001Glover TW\u3001Collins FS\u3002\u00a0\u81ea\u7136<\/em>. 2003 \u5e74 5 \u6708 15 \u65e5;423(6937):293-8\u30022003 \u5e74 4 \u6708 25 \u65e5\u7535\u5b50\u7248\u3002<\/p>\n

[\/et_pb_text][et_pb_textadmin_label=\u201dHGMLBV081\u2033module_id=\u201dHGMLBV081\u2033_builder_version=\u201d4.16\u2033custom_margin=\u201d50px||50px||true\u201dz_index_tablet=\u201d500\u2033global_colors_info=\u201d{}\u201d]<\/p>\n

HGMLBV081<\/strong><\/h4>\n

\u5c42\u86cb\u767d A \u4e2d\u53cd\u590d\u53d1\u751f\u7684\u65b0\u751f\u70b9\u7a81\u53d8\u5bfc\u81f4\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u3002<\/a>
Eriksson M\u3001Brown WT\u3001Gordon LB\u3001Glynn MW\u3001Singer J\u3001Scott L\u3001Erdos MR\u3001Robbins CM\u3001Moses TY\u3001Berglund P\u3001Dutra A\u3001Pak E\u3001Durkin S\u3001Csoka AB\u3001Boehnke M\u3001Glover TW\u3001Collins FS\u3002\u00a0\u81ea\u7136<\/em>. 2003 \u5e74 5 \u6708 15 \u65e5;423(6937):293-8\u30022003 \u5e74 4 \u6708 25 \u65e5\u7535\u5b50\u7248\u3002<\/p>\n

[\/et_pb_text][et_pb_text]admin_label=\u201dHGFLBV082\u2033 module_id=\u201dHGFLBV082\u2033 _builder_version=\u201d4.16\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

HGFLBV082<\/strong><\/h4>\n

\u5c42\u86cb\u767d A \u4e2d\u53cd\u590d\u53d1\u751f\u7684\u65b0\u751f\u70b9\u7a81\u53d8\u5bfc\u81f4\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u3002<\/a>
Eriksson M\u3001Brown WT\u3001Gordon LB\u3001Glynn MW\u3001Singer J\u3001Scott L\u3001Erdos MR\u3001Robbins CM\u3001Moses TY\u3001Berglund P\u3001Dutra A\u3001Pak E\u3001Durkin S\u3001Csoka AB\u3001Boehnke M\u3001Glover TW\u3001Collins FS\u3002\u00a0\u81ea\u7136<\/em>. 2003 \u5e74 5 \u6708 15 \u65e5;423(6937):293-8\u30022003 \u5e74 4 \u6708 25 \u65e5\u7535\u5b50\u7248\u3002<\/p>\n

[\/et_pb_text][et_pb_text]admin_label=\u201dDNA\u201d module_id=\u201dDNA\u201d _builder_version=\u201d4.17.4\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

\u8131\u6c27\u6838\u7cd6\u6838\u9178<\/strong><\/h4>\n

\u514b\u9686\u6027\u9020\u8840\u5728\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u4e2d\u5e76\u4e0d\u666e\u904d<\/a>
D\u00edez-D\u00edez M\u3001Amor\u00f3s-P\u00e9rez M\u3001de la Barrera J \u7b49\u3002 [\u5370\u5237\u524d\u5728\u7ebf\u53d1\u5e03\uff0c2022 \u5e74 6 \u6708 25 \u65e5]\u3002\u8001\u5e74\u79d1\u5b66\u3002 2022\uff1b10.1007\/s11357-022-00607-2\u3002 doi:10.1007\/s11357-022-00607-2<\/p>\n

\u4e00\u79cd\u65b0\u578b\u4f53\u7ec6\u80de\u7a81\u53d8\u4f7f\u60a3\u6709\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u513f\u7ae5\u83b7\u5f97\u90e8\u5206\u6551\u6cbb<\/a>
\u5df4\u5c14 DZ\u3001Arlt MF\u3001Brazier JF \u7b49\u4eba\u3002 \u533b\u5b66\u9057\u4f20\u5b66\u6742\u5fd7<\/em> 2017\uff1b54(3):212-216\u3002 doi:10.1136\/jmedgenet-2016-104295<\/p>\n

\u6682\u65f6\u5f15\u5165\u4eba\u7c7b\u7aef\u7c92\u9176 mRNA \u53ef\u6539\u5584\u65e9\u8870\u7ec6\u80de\u7684\u7279\u5f81<\/a>
\u674eY\uff0c\u5468G\uff0cBruno IG\uff0c\u7b49\u3002 \u8870\u8001\u7ec6\u80de<\/em> 2019\uff1b18(4):e12979\u3002 doi\uff1a10.1111\/acel.12979<\/p>\n

\u76ae\u80a4\u548c\u8840\u7ec6\u80de\u7684\u8868\u89c2\u9057\u4f20\u65f6\u949f\u5e94\u7528\u4e8e\u54c8\u94a6\u68ee\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u548c\u79bb\u4f53\u7814\u7a76<\/a>
Horvath S\u3001Oshima J\u3001Martin GM \u7b49\u4eba\u3002 \u8001\u5316<\/em> \uff08\u7ebd\u7ea6\u5dde\u5965\u5c14\u5df4\u5c3c\uff09\u3002 2018\uff1b10(7):1758-1775\u3002 doi\uff1a10.18632\/aging.101508<\/p>\n

[\/et_pb_text][et_pb_text admin_label=\u201d\u5c38\u68c0\u7ec4\u7ec7\u201d module_id=\u201d\u5c38\u68c0\u7ec4\u7ec7\u201d _builder_version=\u201d4.24.0\u2033 custom_margin=\u201d50px||50px||true\u201d z_index_tablet=\u201d500\u2033 global_colors_info=\u201d{}\u201d]<\/p>\n

\u5c38\u68c0\u7ec4\u7ec7<\/strong><\/h4>\n

\u5fc3\u810f\u7ec6\u80de\u5916\u57fa\u8d28\u86cb\u767d\u8d28\u7ec4\u5728\u751f\u7406\u548c\u75c5\u7406\u8870\u8001\u8fc7\u7a0b\u4e2d\u7684\u91cd\u5851<\/a>
Santinha D\u3001Vila\u00e7a A\u3001Estronca L \u7b49\u3002\u00a0\u5206\u5b50\u7ec6\u80de\u86cb\u767d\u8d28\u7ec4\u5b66<\/em>\u3002 2024\uff1b23(1)\uff1a100706\u3002 doi:10.1016\/j.mcpro.2023.100706<\/p>\n

\u53e4\u4ee3\u4eba\u7c7b\u7684\u52a8\u8109\u7ca5\u6837\u786c\u5316\u3001\u52a0\u901f\u8870\u8001\u7efc\u5408\u5f81\u548c\u6b63\u5e38\u8870\u8001\uff1a\u5c42\u86cb\u767d\u662f\u4e00\u79cd\u5e38\u89c1\u7684\u8054\u7cfb\u5417\uff1f<\/a>
\u5bab\u672c MI\u3001Djabali K\u3001\u6208\u767b LB\u3002 \u5fc3\u5f62<\/em>. 2014;9(2):211-218. doi:10.1016\/j.gheart.2014.04.001<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u7684\u5fc3\u8840\u7ba1\u75c5\u7406\u5b66\uff1a\u4e0e\u8870\u8001\u8840\u7ba1\u75c5\u7406\u5b66\u7684\u76f8\u5173\u6027<\/a>
Olive M\u3001Harten I\u3001Mitchell R \u7b49\u4eba\u3002 \u52a8\u8109\u786c\u5316\u8840\u6813\u8840\u7ba1\u751f\u7269\u5b66<\/em> 2010\uff1b30(11):2301-2309\u3002\u53f7\u7801\uff1a10.1161\/ATVBAHA.110.209460<\/p>\n

\u6297\u5c42\u86cb\u767d A G608G \u6297\u4f53\u68c0\u6d4b\u53d1\u73b0\uff0c\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u7a81\u53d8\u5c42\u86cb\u767d A \u4e3b\u8981\u9776\u5411\u4eba\u7c7b\u8840\u7ba1\u7ec6\u80de<\/a>
\u9ea6\u514b\u6797\u6258\u514b D\u3001\u6208\u767b LB\u3001\u8d3e\u5df4\u5229 K. \u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a\u3002<\/em> 2006\uff1b103(7)\uff1a2154-2159\u3002 doi:10.1073\/pnas.0511133103<\/p>\n

[\/et_pb_text][et_pb_textadmin_label=\u201d\u7b49\u79bb\u5b50\u201dmodule_id=\u201d\u7b49\u79bb\u5b50\u201d_builder_version=\u201d4.24.0\u2033custom_margin=\u201d50px||50px||true\u201dz_index_tablet=\u201d500\u2033global_colors_info=\u201d{}\u201d]<\/p>\n

\u7b49\u79bb\u5b50\u4f53<\/strong><\/h4>\n

\u8001\u5316\u8840\u7ba1\u5fae\u73af\u5883\u901a\u8fc7\u65c1\u5206\u6ccc\u6291\u5236 Wnt \u8f74\u963b\u788d\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7684\u6210\u9aa8\u4f5c\u7528<\/a>
Fleischhacker V\u3001Milosic F\u3001Bricelj M \u7b49\u3002\u00a0\u8870\u8001\u7ec6\u80de<\/em>\u3002 2024 \u5e74 4 \u6708 5 \u65e5\u5728\u7ebf\u53d1\u5e03\u3002doi:10.1111\/acel.14139<\/p>\n

\u4ee3\u8c22\u7ec4\u5b66\u5206\u6790\u8868\u660e\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u8bf1\u53d1\u7684\u8fc7\u65e9\u8870\u8001\u7684\u7cfb\u7edf\u7279\u5f81<\/a>
Monnerat G\u3001Evaristo GPC\u3001Evaristo JAM \u7b49\u3002 \u4ee3\u8c22\u7ec4\u5b66<\/em> 2019;15(7):100\u30022019 \u5e74 6 \u6708 28 \u65e5\u53d1\u5e03\u3002doi:10.1007\/s11306-019-1558-6<\/p>\n

\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u60a3\u8005\u8840\u6d46\u65e9\u8870\u86cb\u767d\uff1a\u514d\u75ab\u6d4b\u5b9a\u7684\u53d1\u5c55\u548c\u4e34\u5e8a\u8bc4\u4ef7<\/a>
\u6208\u767b LB\u3001\u8bfa\u91cc\u65af W\u3001\u54c8\u59c6\u4f26 S \u7b49\u3002\u00a0\u5faa\u73af<\/em>\u3002 2023\uff1b147(23)\uff1a1734-1744\u3002 doi:10.1161\/\u5faa\u73afAHA.122.060002<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”Serum” module_id=”Serum” _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

\u8840\u6e05<\/strong><\/h4>\n

\u4eba\u7c7b\u5e73\u6ed1\u808c\u7ec6\u80de\u548c\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u7684\u76f4\u63a5\u91cd\u7f16\u7a0b\u63ed\u793a\u4e86\u4e0e\u8870\u8001\u548c\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u76f8\u5173\u7684\u7f3a\u9677<\/a>
Bersini S\u3001Schulte R\u3001Huang L\u3001Tsai H\u3001Hetzer MW\u3002 \u57c3\u5229\u592b<\/em>. 2020 \u5e74 9 \u6708 8 \u65e5\uff1b9\uff1ae54383\u3002doi\uff1a10.7554\/eLife.54383\u3002PMID\uff1a32896271\uff1bPMCID\uff1aPMC7478891\u3002<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”Buffy Coats” module_id=”buffycoats” _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

\u8840\u6c89\u9ec4\u5c42<\/strong><\/h4>\n

\u901a\u8fc7\u8d28\u8c31\u6cd5\u5bf9\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u75c7\u60a3\u8005\u7ec6\u80de\u4e2d\u7684\u6cd5\u5462\u57fa\u5316\u65e9\u8870\u86cb\u767d\u8fdb\u884c\u5b9a\u91cf\u5206\u6790<\/a>
\u5361\u9a6c\u83f2\u5854 E\u3001\u8c6a\u5c14\u8d6b\u4e00\u4e16\u3001\u91cc\u7ef4\u62c9-\u6258\u96f7\u65af J\u3001\u5b89\u5fb7\u70c8\u65af V\u3001\u5df4\u65af\u514b\u65af J. \u56fd\u9645\u5206\u5b50\u79d1\u5b66\u6742\u5fd7<\/em>. 2022;23(19):11733\u30022022 \u5e74 10 \u6708 3 \u65e5\u53d1\u5e03\u3002doi:10.3390\/ijms231911733<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”Zokinvy (lonafarnib)” module_id=”zokinvy” _builder_version=”4.27.4″ custom_margin=”50px||50px||true” z_index_tablet=”500″ global_colors_info=”{}”]<\/p>\n

Zokinvy\uff08lonafarnib\uff09 <\/strong><\/h4>\n

\u5df4\u745e\u66ff\u5c3c\u548c\u6d1b\u90a3\u6cd5\u5c3c\u534f\u540c\u4f5c\u7528\uff0c\u9776\u5411\u65e9\u8870\u86cb\u767d\u548c\u708e\u75c7\uff0c\u6539\u5584\u65e9\u8870\u5c0f\u9f20\u7684\u5bff\u547d\u548c\u5065\u5eb7\u72b6\u51b5<\/a>
Kr\u00fcger P\u3001Schroll M\u3001Fenzl FQ \u7b49\u4eba\u3002\u00a0\u56fd\u9645\u5206\u5b50\u79d1\u5b66\u6742\u5fd7<\/em>. 2025;26(10):4849. \u53d1\u8868\u4e8e 2025 \u5e74 5 \u6708 19 \u65e5\u3002doi:10.3390\/ijms26104849<\/p>\n

\u6cd5\u5462\u57fa\u8f6c\u79fb\u9176\u6291\u5236\u5242 (FTI) lonafarnib \u53ef\u6539\u5584\u65e9\u8870\u75c7 MAD-B \u60a3\u8005 ZMPSTE24 \u7f3a\u9677\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u6838\u5f62\u6001<\/a>
Odinammadu KO\u3001Shilagardi K\u3001Tuminelli K\u3001Judge DP\u3001Gordon LB\u3001Michaelis S. \u6838<\/em>. 2023;14(1):2288476.doi:10.1080\/19491034.2023.2288476<\/p>\n

\u6d1b\u7eb3\u6cd5\u5c3c\u548c\u4f9d\u7ef4\u83ab\u53f8\u53ef\u51cf\u8f7b\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81 iPSC \u884d\u751f\u7ec4\u7ec7\u5de5\u7a0b\u8840\u7ba1\u6a21\u578b\u4e2d\u7684\u75c5\u7406\u3002<\/a>
Abutaleb NO\u3001Atchison L\u3001Choi L\u3001Bedapudi A\u3001Shores K\u3001Gete Y\u3001Cao K\u3001Truskey GA\u3002Sci Rep. 2023 \u5e74 3 \u6708 28 \u65e5\uff1b13(1):5032\u3002doi\uff1a10.1038\/s41598-023-32035-3\u3002PMID\uff1a36977745\uff1bPMCID\uff1aPMC10050176\u3002<\/p>\n

Lonafarnib \u53ef\u6539\u5584\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u5c0f\u9f20\u6a21\u578b\u7684\u5fc3\u8840\u7ba1\u529f\u80fd\u548c\u751f\u5b58\u7387\u3002<\/a>
Murtada SI\u3001Mikush N\u3001Wang M\u3001Ren P\u3001Kawamura Y\u3001Ramachandra AB\u3001Li DS\u3001Braddock DT\u3001Tellides G\u3001Gordon LB\u3001Humphrey JD\u3002\u57c3\u83b1\u592b\u3002 2023 \u5e74 3 \u6708 17 \u65e5\uff1b12\uff1ae82728\u3002 doi\uff1a10.7554\/eLife.82728\u3002\u7535\u8bdd\u53f7\u7801\uff1a36930696\uff1b PMCID\uff1aPMC10023154\u3002<\/p>\n

\u7cfb\u7edf\u7b5b\u9009\u786e\u5b9a\u4e86\u6cbb\u7597\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u53cd\u4e49\u5be1\u6838\u82f7\u9178\u3002 <\/a>
Puttaraju M\u3001Jackson M\u3001Klein S\u3001Shilo A\u3001Bennett CF\u3001Gordon L\u3001Rigo F\u3001Misteli T. Nat Med\u3002 2021 \u5e74 3 \u6708\uff1b27(3):526-535\u3002 DOI\uff1a10.1038\/s41591-021-01262-4\u3002 Epub 2021 \u5e74 3 \u6708 11 \u65e5\u3002PMID\uff1a33707772\u3002<\/p>\n

Progerinin \u662f\u4e00\u79cd\u4f18\u5316\u7684\u65e9\u8870\u86cb\u767d-\u5c42\u86cb\u767d A \u7ed3\u5408\u6291\u5236\u5242\uff0c\u53ef\u6539\u5584\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u8fc7\u65e9\u8870\u8001\u8868\u578b\u3002<\/a>
Kang SM\u3001Yoon MH\u3001Ahn J\u3001Kim JE\u3001Kim SY\u3001Kang SY\u3001Joo J\u3001Park S\u3001Cho JH\u3001Woo TG\u3001Oh AY\u3001Chung KJ\u3001An SY\u3001Hwang TS\u3001Lee SY\u3001Kim JS\u3001Ha NC\u3001Song GY\u3001Park BJ\u3002\u516c\u5171\u751f\u7269\u5b66\u3002 2021 \u5e74 1 \u6708 4 \u65e5\uff1b4(1):5\u3002 doi\uff1a10.1038\/s42003-020-01540-w\u3002\u52d8\u8bef\u8868\uff1aCommun Biol\u3002 2021 \u5e74 3 \u6708 2 \u65e5\uff1b4(1):297\u3002\u7535\u8bdd\u53f7\u7801\uff1a33398110\uff1b PMCID\uff1aPMC7782499\u3002<\/p>\n

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[\/et_pb_cta][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2026\/03\/2026-footer-image-copy.png” title_text=”2026 footer image copy” _builder_version=”4.27.5″ _module_preset=”default” custom_margin=”35px||||false|false” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"

[et_pb_section fb_built=\u201d1\u2033 \u5168\u5bbd=\u201d\u5f00\u542f\u201d disabled_on=\u201d\u5173\u95ed|\u5173\u95ed|\u5173\u95ed\u201d _builder_version=\u201d4.16\u2033 border_width_bottom=\u201d55px\u201d border_color_bottom=\u201d#29327a\u201d fixed=\u201d\u5173\u95ed\u201d global_colors_info=\u201d{}\u201d][et_pb_fullwidth_header _builder_version=\u201d4.16\u2033 title_font=\u201d|||||||||\u201d title_font_size=\u201d55\u2033 background_color=\u201d#29327a\u201d background_image=\u201dhttps:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2020\/12\/Alexandra_1920x687.jpg\u201d background_position=\u201dcenter_left\u201d custom_padding=\u201d9vw||9vw||true\u201d custom_padding_tablet=\u201d\u201d custom_padding_phone=\u201d|56px||\u201d custom_padding_last_edited=\u201d\u5728|\u684c\u9762\u201d title_font_size_tablet=\u201d45px\u201d title_font_size_phone=\u201d40px\u201d title_font_size_last_edited=\u201d\u5728|\u7535\u8bdd\u201d z_index_tablet=\u201d500\u2033 custom_css_main_element=\u201dbackground-position: center 18% !important;\u201d global_colors_info=\u201d{}\u201d] PRF \u7ec6\u80de\u548c\u7ec4\u7ec7\u5e93\u51fa\u7248\u7269 [\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=\u201d1\u2033 use_custom_gutter=\u201don\u201d gutter_width=\u201d1\u2033 speciality=\u201don\u201d padding_left_1=\u201d35px\u201d padding_left_2=\u201d35px\u201d padding_2_tablet=\u201d|||0px\u201d padding_2_phone=\u201d|||0px\u201d padding_2_last_edited=\u201don|desktop\u201d module_class_1=\u201dsidebar-secondary-nav\u201d module_class=\u201dhandprint-bg\u201d _builder_version=\u201d4.16\u2033 background_image=\u201dhttps:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/04\/blue-handprint-only.png\u201d parallax=\u201don\u201d parallax_method=\u201doff\u201d inner_width=\u201d100%\u201d inner_max_width=\u201d100%\u201d custom_padding=\u201d0|0px|54px|0px|false|false\u201d z_index_tablet=\u201d500\u2033 [\u2026]<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"\t\t\t\t[vc_row][vc_column][vc_custom_heading text=\"PRF Cell and Tissue Bank Publications\" font_container=\"tag:h1|text_align:center\" use_theme_fonts=\"yes\"][vc_column_text]Publications Stemming From\r\n<\/strong>The Progeria Research Foundation Cell and Tissue Bank\r\n\r\n<\/a>The Progeria Research Foundation Cell and Tissue Bank has contributed to the following medical publications, categorized by cell line for researcher convenience:\r\n\r\n\r\n\r\n
HGADFN001<\/strong><\/a>\r\n\r\nHGADFN003<\/strong><\/a>\r\n\r\nHGADFN004<\/strong><\/a>\r\n\r\nHGADFN005<\/strong><\/a>\r\n\r\nHGADFN008<\/strong><\/a>\r\n\r\nHGADFN014<\/strong><\/a>\r\n\r\nHGADFN086<\/strong><\/a>\r\n\r\nHGMDFN090<\/strong><\/a>\r\n\r\nHGADFN122<\/b><\/strong><\/a>\r\n\r\nHGADFN127<\/strong><\/a>\r\n\r\nHGADFN136<\/strong><\/a>\r\n\r\nHGADFN143<\/strong><\/a>\r\n\r\nHGADFN155<\/strong><\/a><\/td>\r\nHGADFN164<\/strong><\/a>\r\n\r\nHGADFN167<\/strong><\/a>\r\n\r\nHGFDFN168<\/strong><\/a>\r\n\r\nHGADFN169<\/strong><\/a>\r\n\r\nHGADFN178<\/strong><\/a>\r\n\r\nHGADFN188<\/strong><\/a>\r\n\r\nPSADFN257<\/strong><\/a>\r\n\r\nPSFDFN319<\/strong><\/a>\r\n\r\nPSMDFN320<\/strong><\/a>\r\n\r\nPSMDFN327<\/strong><\/a>\r\n\r\nPSMDFN346<\/strong><\/a>\r\n\r\nPSMDFN392<\/strong><\/a>\r\n\r\nHGALBV009<\/strong><\/a>\r\n\r\nHGMLBV010<\/strong><\/a><\/td>\r\nHGALBV011<\/strong><\/a>\r\n\r\nHGMLBV013<\/strong><\/a>\r\n\r\nHGFLBV021<\/strong><\/a>\r\n\r\nHGMLBV023<\/strong><\/a>\r\n\r\nHGFLBV031<\/strong><\/a>\r\n\r\nHGFLBV050<\/strong><\/a>\r\n\r\nHGALBV057<\/strong><\/a>\r\n\r\nHGMLBV058<\/strong><\/a>\r\n\r\nHGSLBV059<\/strong><\/a>\r\n\r\nHGMLBV066<\/a><\/strong>\r\n\r\nHGFLBV067<\/strong><\/a>\r\n\r\nHGALBV071<\/strong><\/a>\r\n\r\nHGMLBV081<\/strong><\/a>\r\n\r\nHGFLBV082<\/strong><\/a><\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n\u00a0\r\n\r\n\"\"For publications listed by cell line inclusion, Click here.<\/a><\/strong>\r\n<\/strong>\r\n

<\/a>HGADFN001<\/strong><\/p>\r\n

Age-dependent loss of MMP-3 in Hutchinson-Gilford progeria syndrome.<\/a>\r\nHarten IA, Zahr RS, Lemire JM, Machan JT, Moses MA, Doiron RJ, Curatolo AS, Rothman FG, Wight TN, Toole BP, Gordon LB. J Gerontol A Biol Sci Med Sci<\/em>. 2011 Nov;66(11):1201-7.<\/p>\r\n

The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin.<\/a>\r\nMcClintock D, Ratner D, Lokuge M, Owens DM, Gordon LB, Collins FS, Djabali K. PLoS One<\/em>. 2007 Dec 5;2(12):e1269.<\/p>\r\n

Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody.<\/a>\r\nMcClintock D, Gordon LB, Djabali K. Proc Natl Acad Sci U S A.<\/em> 2006 Feb 14;103(7):2154-9.<\/p>\r\n

Aggrecan expression is substantially and abnormally upregulated in Hutchinson-Gilford Progeria Syndrome dermal fibroblasts.<\/a>\r\nLemire JM, Patis C, Gordon LB, Sandy JD, Toole BP, Weiss AS. Mech Ageing Dev.<\/em> 2006 Aug;127(8):660-9.<\/p>\r\n

Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment.<\/a>\r\nColumbaro M, Capanni C, Mattioli E, Novelli G, Parnaik VK, Squarzoni S, Maraldi NM, Lattanzi G. Cell Mol Life Sci.<\/em> 2005 Nov;62(22):2669-78.<\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature.<\/em> 2003 May 15;423(6937):293-8.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGADFN003<\/strong><\/p>\r\nA\u00a0Cell-Intrinsic\u00a0Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.\r\n<\/a>Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S.\u00a0Cell Rep<\/em>. 2018 Feb 20;22(8):2006-2015.\r\n

Nucleoplasmic\u00a0lamins\u00a0define\u00a0growth-regulating functions of lamina-associated polypeptide 2\u03b1 in progeria cells.<\/a>\u00a0Vidak S, Georgiou K, Fichtinger P, Naetar N, Dechat T, Foisner R. J Cell Sci. 2017 Dec 28. pii: jcs.208462. doi: 10.1242\/jcs.208462. [Epub ahead of print]<\/p>\r\n

Intermittent\u00a0treatment\u00a0with\u00a0farnesyltransferase\u00a0inhibitor\u00a0and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts.\u00a0<\/a>Gabriel D, Shafry DD, Gordon LB, Djabali K.\u00a0Oncotarget<\/em>. 2017 Jul 18;8(39):64809-64826. doi: 10.18632\/oncotarget.19363. eCollection 2017 Sep 12.<\/p>\r\nReprogramming\u00a0progeria\u00a0fibroblasts\u00a0re-establishes a normal epigenetic landscape.<\/span><\/a>\u00a0Chen Z, Chang WY, Etheridge A, Strickfaden H, Jin Z, Palidwor G, Cho JH, Wang K, Kwon SY, Dor\u00e9 C, Raymond A, Hotta A, Ellis J, Kandel RA, Dilworth FJ, Perkins TJ, Hendzel MJ, Galas DJ, Stanford WL. .<\/span>Aging Cell<\/span><\/i>. 2017 Jun 8. [Epub ahead of print]<\/span>\r\n\r\nPermanent\u00a0farnesylation\u00a0of\u00a0lamin A\u00a0mutants linked to progeria impairs its phosphorylation at serine 22 during interphase.<\/span><\/a> Moiseeva O, Lopes-Paciencia S, Huot G, Lessard F, Ferbeyre G. <\/span>Aging<\/span><\/i> . 2016 Feb;8(2):366-81.<\/span>\r\n\r\nLamin A\u00a0Is an\u00a0Endogenous\u00a0SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair.<\/span><\/a>\u00a0Ghosh S, Liu B, Wang Y, Hao Q, Zhou Z. <\/span>Cell Rep<\/span><\/i>. 2015 Nov 17;13(7):1396-1406. doi: 10.1016\/j.celrep.2015.10.006. Epub 2015 Nov 5. PMID:26549451<\/span>\r\n

Proliferation\u00a0of\u00a0progeria\u00a0cells\u00a0is\u00a0enhanced\u00a0by\u00a0lamina-associated polypeptide 2\u03b1 (LAP2\u03b1) through expression of extracellular matrix proteins.\r\n<\/a>Vidak S, Kubben N, Dechat T, Foisner R. Genes & Development.<\/i> 2015 Oct 1;29(19):2022-36.<\/p>\r\n

Sulforaphane\u00a0enhances\u00a0progerin clearance in Hutchinson-Gilford progeria fibroblasts.\r\n<\/a>Gabriel D, Roedl D, Gordon LB, Djabali K. Aging Cell<\/i>. 2014 Dec 16: 1-14.<\/p>\r\n

Depleting\u00a0the\u00a0methyltransferase\u00a0Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.\r\n<\/a>Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z.Nat Commun<\/i>. 2013;4:1868.<\/p>\r\n

Na\u00efve\u00a0adult stem cells\u00a0from\u00a0patients\u00a0with\u00a0Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo.\r\n<\/a>Wenzel V, Roedl D, Gabriel D, Gordon LB, Herlyn M, Schneider R, Ring J, Djabali K.\r\nBiol Open<\/em>. 2012 Jun 15;1(6):516-26. Epub 2012 Apr 16<\/p>\r\n

Age-dependent loss of MMP-3 in Hutchinson-Gilford progeria syndrome.\r\n<\/a>Harten IA, Zahr RS, Lemire JM, Machan JT, Moses MA, Doiron RJ, Curatolo AS, Rothman FG, Wight TN, Toole BP, Gordon LB. J Gerontol A Biol Sci Med Sci<\/em>. 2011 Nov;66(11):1201-7.<\/p>\r\n

Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts.<\/a>\r\nCao K, Blair CD, Faddah DA, Kieckhaefer JE, Olive M, Erdos MR, Nabel EG, Collins FS. J Clin Invest.<\/em> 2011 Jul 1;121(7):2833-44<\/p>\r\n

Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition.<\/a>\r\nMarji J, O'Donoghue SI, McClintock D, Satagopam VP, Schneider R, Ratner D, Worman HJ, Gordon LB, Djabali K. PLoS One<\/em>. 2010 Jun 15;5(6):e11132.<\/p>\r\n

Effect of progerin on the accumulation of oxidized proteins in fibroblasts from Hutchinson Gilford progeria patients.<\/a>\r\nViteri G, Chung YW, Stadtman ER. Mech Ageing Dev<\/em>. 2010 Jan;131(1):2-8.<\/p>\r\n

Ageing-related chromatin defects through loss of the NURD complex.<\/a>\r\nPegoraro G, Kubben N, Wickert U, G\u00f6hler H, Hoffmann K, Misteli T. Nat Cell Biol.<\/em> 2009 Oct;11(10):1261-7.<\/p>\r\n

Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing.<\/a>\r\nScaffidi P, Misteli T. Nat Cell Biol. <\/em>2008 Apr;10(4):452-9.<\/p>\r\n

Perturbation of wild-type lamin A metabolism results in a progeroid phenotype.<\/a>\r\nCandelario J, Sudhakar S, Navarro S, Reddy S, Comai L. Aging Cell<\/em>. 2008 Jun;7(3):355-67<\/p>\r\n

Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging.<\/a>\r\nDechat T, Shimi T, Adam SA, Rusinol AE, Andres DA, Spielmann HP, Sinensky MS, Goldman RD. Proc Natl Acad Sci USA<\/em>. 2007 Mar 20;104(12):4955-60.<\/p>\r\n

The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin.<\/a>\r\nMcClintock D, Ratner D, Lokuge M, Owens DM, Gordon LB, Collins FS, Djabali K. PLoS One<\/em>. 2007 Dec 5;2(12):e1269.<\/p>\r\n

A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells.<\/a>\r\nCao K, Capell BC, Erdos MR, Djabali K, Collins FS. Proc Natl Acad Sci USA<\/em>. 2007 Mar 20;104(12):4949-54.<\/p>\r\n

Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody.<\/a>\r\nMcClintock D, Gordon LB, Djabali K. Proc Natl Acad Sci U S A.<\/em> 2006 Feb 14;103(7):2154-9.<\/p>\r\n

Aggrecan expression is substantially and abnormally upregulated in Hutchinson-Gilford Progeria Syndrome dermal fibroblasts.<\/a>\r\nLemire JM, Patis C, Gordon LB, Sandy JD, Toole BP, Weiss AS. Mech Ageing Dev.<\/em> 2006 Aug;127(8):660-9.<\/p>\r\n

Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment.<\/a>\r\nColumbaro M, Capanni C, Mattioli E, Novelli G, Parnaik VK, Squarzoni S, Maraldi NM, Lattanzi G. Cell Mol Life Sci.<\/em> 2005 Nov;62(22):2669-78.<\/p>\r\n

Genomic instability in laminopathy-based premature aging.<\/a>\r\nLiu B, Wang J, Chan KM, Tjia WM, Deng W, Guan X, Huang JD, Li KM, Chau PY, Chen DJ, Pei D, Pendas AM, Cadi\u00f1anos J, L\u00f3pez-Ot\u00edn C, Tse HF, Hutchison C, Chen J, Cao Y, Cheah KS, Tryggvason K, Zhou Z. Nat Med.<\/em> 2005 Jul;11(7):780-5.<\/p>\r\n

Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition.<\/a>\r\nGlynn MW, Glover TW. Hum Mol Genet. <\/em>2005 Oct 15;14(20):2959-69.<\/p>\r\n

Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome.<\/a>\r\nGoldman RD, Shumaker DK, Erdos MR, Eriksson M, Goldman AE, Gordon LB, Gruenbaum Y, Khuon S, Mendez M, Varga R, Collins FS. Proc Natl Acad Sci U S A<\/em>.<\/em><\/a> 2004 Jun 15;101(24):8963-8.<\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature.<\/em> 2003 May 15;423(6937):293-8.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGADFN004<\/strong>\u00a0<\/strong><\/p>\r\n

Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition.<\/a>\r\nGlynn MW, Glover TW. Hum Mol Genet. <\/em>2005 Oct 15;14(20):2959-69.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGADFN005<\/strong>\u00a0<\/strong><\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature.<\/em> 2003 May 15;423(6937):293-8.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGADFN008<\/strong>\u00a0<\/strong><\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature.<\/em> 2003 May 15;423(6937):293-8.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGADFN014<\/strong>\u00a0<\/strong><\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature.<\/em> 2003 May 15;423(6937):293-8.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGADFN086<\/strong><\/p>\r\n

Increased progerin expression associated with unusual LMNA mutations causes severe progeroid syndromes.<\/a>\r\nMoulson CL, Fong LG, Gardner JM, Farber EA, Go G, Passariello A, Grange DK, Young SG, Miner JH. Hum Mutat.<\/em> 2007 Sep;28(9):882-9.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGMDFN090<\/strong><\/p>\r\n

A\u00a0Cell-Intrinsic\u00a0Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.\r\n<\/a>Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S.\u00a0Cell Rep<\/em>. 2018 Feb 20;22(8):2006-2015.<\/p>\r\n

Nucleoplasmic\u00a0lamins\u00a0define\u00a0growth-regulating functions of lamina-associated polypeptide 2\u03b1 in progeria cells.<\/a>\u00a0Vidak S, Georgiou K, Fichtinger P, Naetar N, Dechat T, Foisner R. J Cell Sci. 2017 Dec 28. pii: jcs.208462. doi: 10.1242\/jcs.208462. [Epub ahead of print]<\/p>\r\n

Reprogramming\u00a0progeria\u00a0fibroblasts\u00a0re-establishes a normal epigenetic landscape.\u00a0<\/a>Chen Z, Chang WY, Etheridge A, Strickfaden H, Jin Z, Palidwor G, Cho JH, Wang K, Kwon SY, Dor\u00e9 C, Raymond A, Hotta A, Ellis J, Kandel RA, Dilworth FJ, Perkins TJ, Hendzel MJ, Galas DJ, Stanford WL. .Aging Cell<\/em>. 2017 Jun 8. [Epub ahead of print]<\/p>\r\n

Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria.\r\n<\/a>Xiong ZM, Choi JY, Wang K, Zhang H, Tariq Z, Wu D, Ko E, LaDana C, Sesaki H, Cao K. Aging Cell.<\/i><\/a>\u00a0 2015 Dec 14. [Epub ahead of print]<\/p>\r\n

Proliferation\u00a0of\u00a0progeria\u00a0cells\u00a0is\u00a0enhanced\u00a0by\u00a0lamina-associated polypeptide 2\u03b1 (LAP2\u03b1) through expression of extracellular matrix proteins.\r\n<\/a>Vidak S, Kubben N, Dechat T, Foisner R. Genes & Development.<\/i> 2015 Oct 1;29(19):2022-36.<\/p>\r\n

Higher-order\u00a0unfolding\u00a0of satellite heterochromatin is a consistent and early event in cell senescence.\r\n<\/a>Swanson EC, Manning B, Zhang H, Lawrence JB. J Cell Biol<\/i>. 2013 Dec 23;203(6):929-42<\/p>\r\n

Correlated\u00a0alterations\u00a0in\u00a0genome\u00a0organization,\u00a0histone\u00a0methylation, and DNA-lamin A\/C interactions in Hutchinson-Gilford progeria syndrome.\r\n<\/a>McCord RP, Nazario-Toole A, Zhang H, Chines PS, Zhan Y, Erdos MR, Collins FS, Dekker J, Cao K. Genome<\/i>\u00a0Res<\/i>. 2013 Feb;23(2):260-9. Epub 2012 Nov 14.<\/p>\r\n

Comparison of constitutional and replication stress-induced genome structural variation by SNP array and mate-pair sequencing.<\/a>\r\nArlt MF, Ozdemir AC, Birkeland SR, Lyons RH Jr, Glover TW, Wilson TE. Genetics<\/em>. 2011 Mar;187(3):675-83.<\/p>\r\n

Hydroxyurea induces de novo copy number variants in human cells.<\/a>\r\nArlt MF, Ozdemir AC, Birkeland SR, Wilson TE, Glover TW. Proc Natl Acad Sci USA.<\/em> 2011 Oct 18;108(42):17360-5<\/p>\r\n

Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts.<\/a>\r\nCao K, Blair CD, Faddah DA, Kieckhaefer JE, Olive M, Erdos MR, Nabel EG, Collins FS. J Clin Invest.<\/em> 2011 Jul 1;121(7):2833-44<\/p>\r\n

CTP:phosphocholine cytidylyltransferase \u03b1 (CCT\u03b1) and lamins alter nuclear membrane structure without affecting phosphatidylcholine synthesis.<\/a>\r\nGehrig K, Ridgway ND. Biochim Biophys Acta<\/em>. 2011 Jun;1811(6):377-85.<\/p>\r\n

Effect of progerin on the accumulation of oxidized proteins in fibroblasts from Hutchinson Gilford progeria patients.<\/a>\r\nViteri G, Chung YW, Stadtman ER. Mech Ageing Dev<\/em>. 2010 Jan;131(1):2-8.<\/p>\r\n

Replication stress induces genome-wide copy number changes in human cells that resemble polymorphic and pathogenic variants.<\/a>\r\nArlt MF, Mulle JG, Schaibley VM, Ragland RL, Durkin SG, Warren ST, Glover TW. Am J Hum Genet<\/em>. 2009 Mar;84(3):339-50.<\/p>\r\n

A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells.<\/a>\r\nCao K, Capell BC, Erdos MR, Djabali K, Collins FS. Proc Natl Acad Sci USA<\/em>. 2007 Mar 20;104(12):4949-54.<\/p>\r\n

Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition.<\/a>\r\nGlynn MW, Glover TW. Hum Mol Genet. <\/em>2005 Oct 15;14(20):2959-69.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGADFN122<\/b><\/p>\r\nMetformin\u00a0Alleviates\u00a0Aging\u00a0Cellular\u00a0Phenotypes in Hutchinson-Gilford Progeria Syndrome Dermal Fibroblasts<\/span>.<\/span><\/a>\u00a0Park SK, Shin OS.\u00a0<\/span>Exp Dermatol<\/span><\/i>. 2017 Feb 13. [Epub ahead of print]<\/span>\r\n\r\nLamin A\u00a0Is an\u00a0Endogenous\u00a0SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair.<\/span><\/a>\u00a0Ghosh S, Liu B, Wang Y, Hao Q, Zhou Z. <\/span>Cell Rep<\/span><\/i>. 2015 Nov 17;13(7):1396-1406. doi: 10.1016\/j.celrep.2015.10.006. Epub 2015 Nov 5. PMID:26549451<\/span>\r\n

Insights\u00a0into the\u00a0role\u00a0of\u00a0immunosenescence\u00a0during varicella zoster virus infection (shingles) in the aging cell model.\r\n<\/a>Kim JA, Park SK, Kumar M, Lee CH, Shin OS. Oncotarget<\/i>. 2015 Oct 14. [Epub ahead of print]<\/p>\r\n

Depleting\u00a0the\u00a0methyltransferase\u00a0Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.\r\n<\/a>Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z. Nat Commun<\/i>. 2013;4:1868.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGADFN127<\/strong><\/p>\r\n

Intermittent\u00a0treatment\u00a0with\u00a0farnesyltransferase\u00a0inhibitor\u00a0and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts.\u00a0<\/a>Gabriel D, Shafry DD, Gordon LB, Djabali K.\u00a0Oncotarget<\/em>. 2017 Jul 18;8(39):64809-64826. doi: 10.18632\/oncotarget.19363. eCollection 2017 Sep 12.<\/p>\r\nMetformin\u00a0Alleviates\u00a0Aging\u00a0Cellular\u00a0Phenotypes in Hutchinson-Gilford Progeria Syndrome Dermal Fibroblasts<\/span>.<\/span><\/a>\u00a0Park SK, Shin OS.\u00a0<\/span>Exp Dermatol<\/span><\/i>. 2017 Feb 13. [Epub ahead of print]<\/span>\r\n

Insights\u00a0into the\u00a0role\u00a0of\u00a0immunosenescence\u00a0during varicella zoster virus infection (shingles) in the aging cell model.\r\n<\/a>Kim JA, Park SK, Kumar M, Lee CH, Shin OS. Oncotarget<\/i>. 2015 Oct 14. [Epub ahead of print]<\/p>\r\n

Sulforaphane\u00a0enhances\u00a0progerin clearance in Hutchinson-Gilford progeria fibroblasts.\r\n<\/a>Gabriel D, Roedl D, Gordon LB, Djabali K. Aging Cell<\/i>. 2014 Dec 16: 1-14.<\/p>\r\n

A\u00a0proteomic\u00a0study\u00a0of\u00a0Hutchinson-Gilford progeria syndrome: Application of 2D-chromotography in a premature aging disease.\r\n<\/a>Wang L, Yang W, Ju W, Wang P, Zhao X, Jenkins EC, Brown WT, Zhong N. Biochem Biophys Res Commun.<\/i> 2012 Jan 27;417(4):1119-26. Epub 2011 Dec 24.<\/p>\r\n

Age-dependent loss of MMP-3 in Hutchinson-Gilford progeria syndrome.<\/a>\r\nHarten IA, Zahr RS, Lemire JM, Machan JT, Moses MA, Doiron RJ, Curatolo AS, Rothman FG, Wight TN, Toole BP, Gordon LB. J Gerontol A Biol Sci Med Sci<\/em>. 2011 Nov;66(11):1201-7.\r\n<\/strong><\/p>\r\n

CTP:phosphocholine cytidylyltransferase \u03b1 (CCT\u03b1) and lamins alter nuclear membrane structure without affecting phosphatidylcholine synthesis.<\/a>\r\nGehrig K, Ridgway ND. Biochim Biophys Acta<\/em>. 2011 Jun;1811(6):377-85.<\/p>\r\n

Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition.<\/a>\r\nMarji J, O'Donoghue SI, McClintock D, Satagopam VP, Schneider R, Ratner D, Worman HJ, Gordon LB, Djabali K. PLoS One<\/em>. 2010 Jun 15;5(6):e11132.<\/p>\r\n

Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: effects of farnesyltransferase inhibitors.<\/a>\r\nVerstraeten VL, Ji JY, Cummings KS, Lee RT, Lammerding J. Aging Cell.<\/em> 2008 Jun;7(3):383-93.<\/p>\r\n

Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging.<\/a>\r\nDechat T, Shimi T, Adam SA, Rusinol AE, Andres DA, Spielmann HP, Sinensky MS, Goldman RD. Proc Natl Acad Sci USA<\/em>. 2007 Mar 20;104(12):4955-60.<\/p>\r\n

The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin.<\/a>\r\nMcClintock D, Ratner D, Lokuge M, Owens DM, Gordon LB, Collins FS, Djabali K. PLoS One<\/em>. 2007 Dec 5;2(12):e1269.<\/p>\r\n

Aggrecan expression is substantially and abnormally upregulated in Hutchinson-Gilford Progeria Syndrome dermal fibroblasts.<\/a>\r\nLemire JM, Patis C, Gordon LB, Sandy JD, Toole BP, Weiss AS. Mech Ageing Dev<\/em>.<\/em><\/a> 2006 Aug;127(8):660-9<\/p>\r\n

Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody.<\/a>\r\nMcClintock D, Gordon LB, Djabali K. Proc Natl Acad Sci U S A.<\/em> 2006 Feb 14;103(7):2154-9.<\/p>\r\n

Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment.<\/a>\r\nColumbaro M, Capanni C, Mattioli E, Novelli G, Parnaik VK, Squarzoni S, Maraldi NM, Lattanzi G. Cell Mol Life Sci.<\/em> 2005 Nov;62(22):2669-78.<\/p>\r\n

Genomic instability in laminopathy-based premature aging.<\/a>\r\nLiu B, Wang J, Chan KM, Tjia WM, Deng W, Guan X, Huang JD, Li KM, Chau PY, Chen DJ, Pei D, Pendas AM, Cadi\u00f1anos J, L\u00f3pez-Ot\u00edn C, Tse HF, Hutchison C, Chen J, Cao Y, Cheah KS, Tryggvason K, Zhou Z. Nat Med.<\/em> 2005 Jul;11(7):780-5.<\/p>\r\n

Novel progerin-interactive partner proteins hnRNP E1, EGF, Mel 18, and UBC9 interact with lamin A\/C.<\/a>\r\nZhong N, Radu G, Ju W, Brown WT. Biochem Biophys Res Commun. <\/em>2005 Dec 16;338(2):855-61.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGADFN136<\/strong><\/p>\r\n

Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition.<\/a>\r\nGlynn MW, Glover TW. Hum Mol Genet. <\/em>2005 Oct 15;14(20):2959-69.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGADFN143<\/strong><\/p>\r\n

Depleting\u00a0the\u00a0methyltransferase\u00a0Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.\r\n<\/a>Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z. Nat Commun<\/i>. 2013;4:1868.<\/p>\r\n

CTP:phosphocholine cytidylyltransferase \u03b1 (CCT\u03b1) and lamins alter nuclear membrane structure without affecting phosphatidylcholine synthesis.<\/a>\r\nGehrig K, Ridgway ND. Biochim Biophys Acta.<\/em> 2011 Jun;1811(6):377-85.<\/p>\r\n

Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: effects of farnesyltransferase inhibitors.<\/a>\r\nVerstraeten VL, Ji JY, Cummings KS, Lee RT, Lammerding J. Aging Cell.<\/em> 2008 Jun;7(3):383-93.<\/p>\r\n

The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin.<\/a>\r\nMcClintock D, Ratner D, Lokuge M, Owens DM, Gordon LB, Collins FS, Djabali K. PLoS One<\/em>. 2007 Dec 5;2(12):e1269.<\/p>\r\n

Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody.<\/a>\r\nMcClintock D, Gordon LB, Djabali K. Proc Natl Acad Sci U S A.<\/em> 2006 Feb 14;103(7):2154-9.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGADFN155<\/strong><\/p>\r\n

Nucleoplasmic\u00a0lamins\u00a0define\u00a0growth-regulating functions of lamina-associated polypeptide 2\u03b1 in progeria cells.<\/a>\u00a0Vidak S, Georgiou K, Fichtinger P, Naetar N, Dechat T, Foisner R. J Cell Sci. 2017 Dec 28. pii: jcs.208462. doi: 10.1242\/jcs.208462. [Epub ahead of print]<\/p>\r\n

Intermittent\u00a0treatment\u00a0with\u00a0farnesyltransferase\u00a0inhibitor\u00a0and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts.\u00a0<\/a>Gabriel D, Shafry DD, Gordon LB, Djabali K.\u00a0Oncotarget<\/em>. 2017 Jul 18;8(39):64809-64826. doi: 10.18632\/oncotarget.19363. eCollection 2017 Sep 12.<\/p>\r\nLamin A\u00a0Is an\u00a0Endogenous\u00a0SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair.<\/span><\/a>\u00a0Ghosh S, Liu B, Wang Y, Hao Q, Zhou Z. <\/span>Cell Rep<\/span><\/i>. 2015 Nov 17;13(7):1396-1406. doi: 10.1016\/j.celrep.2015.10.006. Epub 2015 Nov 5. PMID:26549451<\/span>\r\n

Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair.\r\n<\/a>Ghosh S, Liu B, Wang Y, Hao Q, Zhou Z. Cell Rep<\/i>. 2015 Nov 4. [Epub ahead of print]<\/p>\r\n

Proliferation\u00a0of\u00a0progeria\u00a0cells\u00a0is\u00a0enhanced\u00a0by\u00a0lamina-associated polypeptide 2\u03b1 (LAP2\u03b1) through expression of extracellular matrix proteins.\r\n<\/a>Vidak S, Kubben N, Dechat T, Foisner R. Genes & Development.<\/i> 2015 Oct 1;29(19):2022-36.<\/p>\r\n

Sulforaphane\u00a0enhances\u00a0progerin clearance in Hutchinson-Gilford progeria fibroblasts.\r\n<\/a>Gabriel D, Roedl D, Gordon LB, Djabali K. Aging Cell<\/i>. 2014 Dec 16: 1-14.<\/p>\r\n

Higher-order\u00a0unfolding\u00a0of satellite heterochromatin is a consistent and early event in cell senescence.\r\n<\/a>Swanson EC, Manning B, Zhang H, Lawrence JB. J Cell Biol<\/i>. 2013 Dec 23;203(6):929-42.<\/p>\r\n

Correlated\u00a0alterations\u00a0in\u00a0genome\u00a0organization,\u00a0histone\u00a0methylation, and DNA-lamin A\/C interactions in Hutchinson-Gilford progeria syndrome.\r\n<\/a>McCord RP, Nazario-Toole A, Zhang H, Chines PS, Zhan Y, Erdos MR, Collins FS, Dekker J, Cao K. Genome<\/i>\u00a0Res<\/i>. 2013 Feb;23(2):260-9. Epub 2012 Nov 14.<\/p>\r\n

An\u00a0inhibitory\u00a0role\u00a0of\u00a0progerin\u00a0in the gene induction network of adipocyte differentiation from iPS cells.\r\n<\/a>Xiong ZM, LaDana C, Wu D, Cao K. Aging<\/i> (Albany NY). 2013 Apr;5(4):288-303.<\/p>\r\n

Depleting\u00a0the\u00a0methyltransferase\u00a0Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.\r\n<\/a>Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z. Nat Commun<\/i>. 2013;4:1868.<\/p>\r\n

Automated\u00a0image\u00a0analysis\u00a0of\u00a0nuclear\u00a0shape: what can we\u00a0learn\u00a0from a prematurely aged cell?\r\n<\/a>Driscoll MK, Albanese JL, Xiong ZM, Mailman M, Losert W, Cao K. Aging<\/i> (Albany NY). 2012 Feb;4(2):119-32.<\/p>\r\n

Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells.<\/a>\r\nCao K, Graziotto JJ, Blair CD, Mazzulli JR, Erdos MR, Krainc D, Collins FS. Sci Transl Med.<\/em> 2011 Jun 29;3(89):89ra58.<\/p>\r\n

Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition.<\/a>\r\nMarji J, O'Donoghue SI, McClintock D, Satagopam VP, Schneider R, Ratner D, Worman HJ, Gordon LB, Djabali K. PLoS One<\/em>. 2010 Jun 15;5(6):e11132.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGADFN164<\/strong><\/p>\r\n

Intermittent\u00a0treatment\u00a0with\u00a0farnesyltransferase\u00a0inhibitor\u00a0and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts.<\/a>Gabriel D, Shafry DD, Gordon LB, Djabali K.\u00a0Oncotarget<\/em>. 2017 Jul 18;8(39):64809-64826. doi: 10.18632\/oncotarget.19363. eCollection 2017 Sep 12.<\/p>\r\nLamin A\u00a0Is an\u00a0Endogenous\u00a0SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair.<\/span><\/a>\u00a0Ghosh S, Liu B, Wang Y, Hao Q, Zhou Z. <\/span>Cell Rep<\/span><\/i>. 2015 Nov 17;13(7):1396-1406. doi: 10.1016\/j.celrep.2015.10.006. Epub 2015 Nov 5. PMID: 26549451<\/span>\r\n

Sulforaphane\u00a0enhances\u00a0progerin clearance in Hutchinson-Gilford progeria fibroblasts.\r\n<\/a>Gabriel D, Roedl D, Gordon LB, Djabali K.\u00a0Aging Cell<\/i>. 2014 Dec 16: 1-14.<\/p>\r\n

Mechanisms\u00a0controlling\u00a0the\u00a0smooth muscle\u00a0cell death in progeria via down-regulation of poly(ADP-ribose) polymerase 1.\r\n<\/a>Zhang H, Xiong ZM, Cao K. Proc Natl Acad Sci<\/i> U S A. 2014 Jun 3;111(22):E2261-70. Epub 2014 May 19.<\/p>\r\n

Correlated\u00a0alterations\u00a0in\u00a0genome\u00a0organization,\u00a0histone\u00a0methylation, and DNA-lamin A\/C interactions in Hutchinson-Gilford progeria syndrome.\r\n<\/a>McCord RP, Nazario-Toole A, Zhang H, Chines PS, Zhan Y, Erdos MR, Collins FS, Dekker J, Cao K. Genome<\/i>\u00a0Res<\/i>. 2013 Feb;23(2):260-9. Epub 2012 Nov 14.<\/p>\r\n

An\u00a0inhibitory\u00a0role\u00a0of\u00a0progerin\u00a0in the gene induction network of adipocyte differentiation from iPS cells.\r\n<\/a>Xiong ZM, LaDana C, Wu D, Cao K. Aging<\/i> (Albany NY). 2013 Apr;5(4):288-303.<\/p>\r\n

Depleting\u00a0the\u00a0methyltransferase\u00a0Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.\r\n<\/a>Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z. Nat Commun<\/i>. 2013;4:1868.<\/p>\r\n

Na\u00efve\u00a0adult stem cells\u00a0from\u00a0patients\u00a0with\u00a0Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo.\r\n<\/a>Wenzel V, Roedl D, Gabriel D, Gordon LB, Herlyn M, Schneider R, Ring J, Djabali K.\r\nBiol Open.<\/i> 2012 Jun 15;1(6):516-26. Epub 2012 Apr 16.<\/p>\r\n

Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition.<\/a>Marji J, O'Donoghue SI, McClintock D, Satagopam VP, Schneider R, Ratner D, Worman HJ, Gordon LB, Djabali K. PLoS One<\/i>. 2010 Jun 15;5(6):e11132.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGADFN167<\/strong><\/p>\r\n

Smurf2\u00a0regulates\u00a0stability\u00a0and the autophagic-lysosomal turnover of lamin A and its disease-associated form progerin.\r\n<\/a>Borroni AP, Emanuelli A, Shah PA, Ili\u0107 N, Apel-Sarid L, Paolini B, Manikoth Ayyathan D, Koganti P, Levy-Cohen G, Blank M.\u00a0Aging Cell<\/em>. 2018 Feb 5. doi: 10.1111\/acel.12732. [Epub ahead of print].<\/p>\r\n

A\u00a0Cell-Intrinsic\u00a0Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.\r\n<\/a>Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S.\u00a0Cell Rep<\/em>. 2018 Feb 20;22(8):2006-2015.<\/p>\r\n

Identification\u00a0of\u00a0novel\u00a0PDE\u03b4 interacting proteins.\u00a0<\/a>K\u00fcchler P, Zimmermann G, Winzker M, Janning P, Waldmann H, Ziegler S.\u00a0Bioorg Med Chem<\/em>. 2017 Aug 31. pii: S0968-0896(17)31182-3. doi: 10.1016\/j.bmc.2017.08.033. [Epub ahead of print]<\/p>\r\n

Nucleolar\u00a0expansion\u00a0and\u00a0elevated\u00a0protein\u00a0translation in premature aging.\r\n<\/a>Buchwalter A, Hetzer MW.\r\nNat Commun. 2017 Aug 30;8(1):328. doi: 10.1038\/s41467-017-00322-z.<\/p>\r\n

Reprogramming\u00a0progeria\u00a0fibroblasts\u00a0re-establishes a normal epigenetic landscape.\u00a0<\/a>Chen Z, Chang WY, Etheridge A, Strickfaden H, Jin Z, Palidwor G, Cho JH, Wang K, Kwon SY, Dor\u00e9 C, Raymond A, Hotta A, Ellis J, Kandel RA, Dilworth FJ, Perkins TJ, Hendzel MJ, Galas DJ, Stanford WL. .Aging Cell<\/em>. 2017 Jun 8. [Epub ahead of print]<\/p>\r\n

Metformin\u00a0Alleviates\u00a0Aging\u00a0Cellular\u00a0Phenotypes in Hutchinson-Gilford Progeria Syndrome Dermal Fibroblasts.<\/a>\r\nPark SK, Shin OS.\r\nExp Dermatol<\/em>. 2017 Feb 13. [Epub ahead of print]<\/p>\r\n

Loss\u00a0of\u00a0H3K9me3\u00a0Correlates with ATM Activation and Histone H2AX Phosphorylation Deficiencies in Hutchinson-Gilford Progeria Syndrome.<\/a>\u00a0Zhang H, Sun L, Wang K, Wu D, Trappio M, Witting C, Cao K.\u00a0PLoS One<\/em>. 2016 Dec 1;11(12):e0167454. doi: 10.1371\/journal.pone.0167454.<\/p>\r\n

NANOG\u00a0reverses\u00a0the\u00a0Myogenic\u00a0Differentiation Potential of Senescent Stem Cells by Restoring ACTIN Filamentous Organization and SRF-Dependent Gene Expression.\u00a0<\/a>Mistriotis P, Bajpai VK, Wang X, Rong N, Shahini A, Asmani M, Liang MS, Wang J, Lei P, Liu S, Zhao R, Andreadis ST.\u00a0Stem Cells<\/em>. 2016 Jun 28. doi: 10.1002\/stem.2452. [Epub ahead of print]<\/p>\r\n

Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria.\r\n<\/a>Xiong ZM, Choi JY, Wang K, Zhang H, Tariq Z, Wu D, Ko E, LaDana C, Sesaki H, Cao K. Aging Cell.<\/i><\/a>\u00a0 2015 Dec 14. [Epub ahead of print]<\/p>\r\n

Insights\u00a0into the\u00a0role\u00a0of\u00a0immunosenescence\u00a0during varicella zoster virus infection (shingles) in the aging cell model.\r\n<\/a>Kim JA, Park SK, Kumar M, Lee CH, Shin OS. Oncotarget<\/i>. 2015 Oct 14. [Epub ahead of print]<\/p>\r\n

Proliferation\u00a0of\u00a0progeria\u00a0cells\u00a0is\u00a0enhanced\u00a0by\u00a0lamina-associated polypeptide 2\u03b1 (LAP2\u03b1) through expression of extracellular matrix proteins.\r\n<\/a>Vidak S, Kubben N, Dechat T, Foisner R. Genes & Development.<\/i> 2015 Oct 1;29(19):2022-36.<\/p>\r\n

Nuclear\u00a0stiffening\u00a0and\u00a0chromatin\u00a0softening with progerin expression leads to an attenuated nuclear\u00a0response to force.\r\n<\/a>Booth EA, Spagnol ST, Alcoser TA, Dahl KN. Soft Matter<\/i>. 2015 Aug 28;11(32):6412-8. Epub 2015 Jul 14.<\/p>\r\n

Phenotype-Dependent\u00a0Coexpression\u00a0Gene\u00a0Clusters: Application to Normal and Premature Ageing.\r\n<\/a>Wang K, Das A, Xiong Z,\u00a0 Cao K, Hannenhalli S. IEEE\/ACM Trans Comput Biol Bioinform<\/i> 2015 Jan-Feb;12(1):30-9.<\/p>\r\n

Mechanisms\u00a0controlling\u00a0the\u00a0smooth muscle\u00a0cell death in progeria via down-regulation of poly(ADP-ribose) polymerase 1.\r\n<\/a>Zhang H, Xiong ZM, Cao K.\u00a0Proc Natl Acad Sci<\/i>\u00a0U S A. 2014 Jun 3;111(22):E2261-70. Epub 2014 May 19.<\/p>\r\n

Higher-order\u00a0unfolding\u00a0of satellite heterochromatin is a consistent and early event in cell senescence.\r\n<\/a>Swanson EC, Manning B, Zhang H, Lawrence JB.\u00a0J Cell Biol<\/i>. 2013 Dec 23;203(6):929-42.<\/p>\r\n

Correlated\u00a0alterations\u00a0in\u00a0genome\u00a0organization,\u00a0histone\u00a0methylation, and DNA-lamin A\/C interactions in Hutchinson-Gilford progeria syndrome.\r\n<\/a>McCord RP, Nazario-Toole A, Zhang H, Chines PS, Zhan Y, Erdos MR, Collins FS, Dekker J, Cao K. Genome<\/i>\u00a0Res<\/i>. 2013 Feb;23(2):260-9. Epub 2012 Nov 14.<\/p>\r\n

Progeria:\u00a0translational\u00a0insights\u00a0from\u00a0cell biology.\r\n<\/a>Gordon LB, Cao K, Collins FS. J\u00a0Cell\u00a0Biol<\/i>. 2012 Oct 1;199(1):9-13. doi: 10.1083\/jcb.201207072.<\/p>\r\n

Automated\u00a0image\u00a0analysis\u00a0of\u00a0nuclear\u00a0shape: what can we\u00a0learn\u00a0from a prematurely aged cell?\r\n<\/a>Driscoll MK, Albanese JL, Xiong ZM, Mailman M, Losert W, Cao K. Aging<\/i> (Albany NY). 2012 Feb;4(2):119-32.<\/p>\r\n

Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders.<\/a>Choi\u00a0S,\u00a0Wang\u00a0W,\u00a0Ribeiro\u00a0AJ, Kalinowski A, Gregg SQ, Opresko PL, Niedernhofer LJ, Rohde GK, Dahl KN. Nucleus<\/i>. 2011 Nov 1;2(6):570-9. Epub 2011 Nov 1.<\/p>\r\n

Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells.<\/a>\r\nCao K, Graziotto JJ, Blair CD, Mazzulli JR, Erdos MR, Krainc D, Collins FS. Sci Transl Med.<\/em> 2011 Jun 29;3(89):89ra58.<\/p>\r\n

Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts.<\/a>\r\nCao K, Blair CD, Faddah DA, Kieckhaefer JE, Olive M, Erdos MR, Nabel EG, Collins FS. J Clin Invest.<\/em> 2011 Jul 1;121(7):2833-44<\/p>\r\n

CTP:phosphocholine cytidylyltransferase \u03b1 (CCT\u03b1) and lamins alter nuclear membrane structure without affecting phosphatidylcholine synthesis.<\/a>\r\nGehrig K, Ridgway ND. Biochim Biophys Acta<\/em>. 2011 Jun;1811(6):377-85.<\/p>\r\n

Effect of progerin on the accumulation of oxidized proteins in fibroblasts from Hutchinson Gilford progeria patients.<\/a>\r\nViteri G, Chung YW, Stadtman ER. Mech Ageing Dev<\/em>. 2010 Jan;131(1):2-8.<\/p>\r\n

A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells.<\/a>\r\nCao K, Capell BC, Erdos MR, Djabali K, Collins FS. Proc Natl Acad Sci USA<\/em>. 2007 Mar 20;104(12):4949-54.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGFDFN168<\/strong><\/p>\r\n

Smurf2\u00a0regulates\u00a0stability\u00a0and the autophagic-lysosomal turnover of lamin A and its disease-associated form progerin.\r\n<\/a>Borroni AP, Emanuelli A, Shah PA, Ili\u0107 N, Apel-Sarid L, Paolini B, Manikoth Ayyathan D, Koganti P, Levy-Cohen G, Blank M.\u00a0Aging Cell<\/em>. 2018 Feb 5. doi: 10.1111\/acel.12732. [Epub ahead of print].<\/span>\u00a0<\/span><\/p>\r\n

Nucleoplasmic\u00a0lamins\u00a0define\u00a0growth-regulating functions of lamina-associated polypeptide 2\u03b1 in progeria cells.<\/a>\u00a0Vidak S, Georgiou K, Fichtinger P, Naetar N, Dechat T, Foisner R. J Cell Sci. 2017 Dec 28. pii: jcs.208462. doi: 10.1242\/jcs.208462. [Epub ahead of print]<\/p>\r\n

Nucleolar\u00a0expansion\u00a0and\u00a0elevated\u00a0protein\u00a0translation in premature aging.<\/a>\u00a0Buchwalter A, Hetzer MW. Nat Commun. 2017 Aug 30;8(1):328. doi: 10.1038\/s41467-017-00322-z.<\/p>\r\n

Reprogramming\u00a0progeria\u00a0fibroblasts\u00a0re-establishes a normal epigenetic landscape.\u00a0<\/a>Chen Z, Chang WY, Etheridge A, Strickfaden H, Jin Z, Palidwor G, Cho JH, Wang K, Kwon SY, Dor\u00e9 C, Raymond A, Hotta A, Ellis J, Kandel RA, Dilworth FJ, Perkins TJ, Hendzel MJ, Galas DJ, Stanford WL. .Aging Cell<\/em>. 2017 Jun 8. [Epub ahead of print]<\/p>\r\n

Loss\u00a0of\u00a0H3K9me3\u00a0Correlates with ATM Activation and Histone H2AX Phosphorylation Deficiencies in Hutchinson-Gilford Progeria Syndrome.<\/a>\u00a0Zhang H, Sun L, Wang K, Wu D, Trappio M, Witting C, Cao K.\u00a0PLoS One<\/em>. 2016 Dec 1;11(12):e0167454. doi: 10.1371\/journal.pone.0167454.<\/p>\r\n

NANOG\u00a0reverses\u00a0the\u00a0Myogenic\u00a0Differentiation Potential of Senescent Stem Cells by Restoring ACTIN Filamentous Organization and SRF-Dependent Gene Expression.<\/a>Mistriotis P, Bajpai VK, Wang X, Rong N, Shahini A, Asmani M, Liang MS, Wang J, Lei P, Liu S, Zhao R, Andreadis ST.\u00a0Stem Cells<\/em>. 2016 Jun 28. doi: 10.1002\/stem.2452. [Epub ahead of print]<\/p>\r\n

Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria.\r\n<\/a>Xiong ZM, Choi JY, Wang K, Zhang H, Tariq Z, Wu D, Ko E, LaDana C, Sesaki H, Cao K.\u00a0Aging Cell.<\/i><\/a>\u00a0 2015 Dec 14. [Epub ahead of print]<\/p>\r\n

Proliferation\u00a0of\u00a0progeria\u00a0cells\u00a0is\u00a0enhanced\u00a0by\u00a0lamina-associated polypeptide 2\u03b1 (LAP2\u03b1) through expression of extracellular matrix proteins.\r\n<\/a>Vidak S, Kubben N, Dechat T, Foisner R. Genes & Development.<\/i> 2015 Oct 1;29(19):2022-36.<\/p>\r\n

Nuclear\u00a0stiffening\u00a0and\u00a0chromatin\u00a0softening with progerin expression leads to an attenuated nuclear\u00a0response to force.\r\n<\/a>Booth EA, Spagnol ST, Alcoser TA, Dahl KN. Soft Matter<\/i>. 2015 Aug 28;11(32):6412-8. Epub 2015 Jul 14.<\/p>\r\n

Phenotype-Dependent\u00a0Coexpression\u00a0Gene\u00a0Clusters: Application to Normal and Premature Ageing.\r\n<\/a>Wang K, Das A, Xiong Z,\u00a0 Cao K, Hannenhalli S. IEEE\/ACM Trans Comput Biol Bioinform<\/i> 2015 Jan-Feb;12(1):30-9.<\/p>\r\n

Mechanisms\u00a0controlling\u00a0the\u00a0smooth muscle\u00a0cell death in progeria via down-regulation of poly(ADP-ribose) polymerase 1.\r\n<\/a>Zhang H, Xiong ZM, Cao K.\u00a0Proc Natl Acad Sci<\/i>\u00a0U S A. 2014 Jun 3;111(22):E2261-70. Epub 2014 May 19.<\/p>\r\n

Correlated\u00a0alterations\u00a0in\u00a0genome\u00a0organization,\u00a0histone\u00a0methylation, and DNA-lamin A\/C interactions in Hutchinson-Gilford progeria syndrome.\r\n<\/a>McCord RP, Nazario-Toole A, Zhang H, Chines PS, Zhan Y, Erdos MR, Collins FS, Dekker J, Cao K. Genome<\/i>\u00a0Res<\/i>. 2013 Feb;23(2):260-9. Epub 2012 Nov 14.<\/p>\r\n

Automated\u00a0image\u00a0analysis\u00a0of\u00a0nuclear\u00a0shape: what can we\u00a0learn\u00a0from a prematurely aged cell?\r\n<\/a>Driscoll MK, Albanese JL, Xiong ZM, Mailman M, Losert W, Cao K. Aging<\/i> (Albany NY). 2012 Feb;4(2):119-32.<\/p>\r\n

Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders.\r\n<\/a>Choi\u00a0S,\u00a0Wang\u00a0W,\u00a0Ribeiro\u00a0AJ, Kalinowski A, Gregg SQ, Opresko PL, Niedernhofer LJ, Rohde GK, Dahl KN. Nucleus<\/i>. 2011 Nov 1;2(6):570-9. Epub 2011 Nov 1.<\/p>\r\n

Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells.<\/a>\r\nCao K, Graziotto JJ, Blair CD, Mazzulli JR, Erdos MR, Krainc D, Collins FS. Sci Transl Med.<\/em> 2011 Jun 29;3(89):89ra58.<\/p>\r\n

Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts.<\/a>\r\nCao K, Blair CD, Faddah DA, Kieckhaefer JE, Olive M, Erdos MR, Nabel EG, Collins FS. J Clin Invest<\/em>.<\/em> 2011 Jul 1;121(7):2833-44<\/p>\r\n

Effect of progerin on the accumulation of oxidized proteins in fibroblasts from Hutchinson Gilford progeria patients.<\/a>\r\nViteri G, Chung YW, Stadtman ER. Mech Ageing Dev<\/em>. 2010 Jan;131(1):2-8.<\/p>\r\n

A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells.<\/a>\r\nCao K, Capell BC, Erdos MR, Djabali K, Collins FS. Proc Natl Acad Sci USA<\/em>. 2007 Mar 20;104(12):4949-54.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGADFN169<\/strong><\/p>\r\n

Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria.\r\n<\/a>Xiong ZM, Choi JY, Wang K, Zhang H, Tariq Z, Wu D, Ko E, LaDana C, Sesaki H, Cao K.\u00a0Aging Cell.<\/i><\/a>\u00a0 2015 Dec 14. [Epub ahead of print]<\/p>\r\nLamin A\u00a0Is an\u00a0Endogenous\u00a0SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair.<\/span><\/a>\u00a0Ghosh S, Liu B, Wang Y, Hao Q, Zhou Z. <\/span>Cell Rep<\/span><\/i>. 2015 Nov 17;13(7):1396-1406. doi: 10.1016\/j.celrep.2015.10.006. Epub 2015 Nov 5. PMID:26549451<\/span>\r\n

Correlated\u00a0alterations\u00a0in\u00a0genome\u00a0organization,\u00a0histone\u00a0methylation, and DNA-lamin A\/C interactions in Hutchinson-Gilford progeria syndrome.\r\n<\/a>McCord RP, Nazario-Toole A, Zhang H, Chines PS, Zhan Y, Erdos MR, Collins FS, Dekker J, Cao K. Genome<\/i>\u00a0Res<\/i>. 2013 Feb;23(2):260-9. Epub 2012 Nov 14.<\/p>\r\n

Depleting\u00a0the\u00a0methyltransferase\u00a0Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.\r\n<\/a>Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z. Nat Commun<\/i>. 2013;4:1868.<\/p>\r\n

Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells.\r\n<\/a>[sta_anchor id=\"fn178\" unsan=\"FN178\"]Cao K, Graziotto JJ, Blair CD, Mazzulli JR, Erdos MR, Krainc D, Collins FS. Sci Transl Med.<\/i> 2011 Jun 29;3(89):89ra58.[\/sta_anchor]<\/p>\r\n\r\n\r\n

\r\n

HGADFN178<\/b><\/p>\r\n

Na\u00efve\u00a0adult stem cells\u00a0from\u00a0patients\u00a0with\u00a0Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo.\r\n<\/a>Wenzel V, Roedl D, Gabriel D, Gordon LB, Herlyn M, Schneider R, Ring J, Djabali K.\r\nBiol Open.<\/i> 2012 Jun 15;1(6):516-26. Epub 2012 Apr 16.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGADFN188<\/strong><\/p>\r\n

p53\u00a0isoforms\u00a0regulate\u00a0premature aging\u00a0in\u00a0human\u00a0cells.\r\n<\/a>von Muhlinen N, Horikawa I, Alam F, Isogaya K, Lissa D, Vojtesek B, Lane DP, Harris CC.\r\nOncogene<\/em>. 2018 Feb 12. doi: 10.1038\/s41388-017-0101-3. [Epub ahead of print]<\/p>\r\n

Sulforaphane\u00a0enhances\u00a0progerin clearance in Hutchinson-Gilford progeria fibroblasts.\r\n<\/a>Gabriel D, Roedl D, Gordon LB, Djabali K. Aging Cell<\/i>. 2014 Dec 16: 1-14.<\/p>\r\n

Depleting\u00a0the\u00a0methyltransferase\u00a0Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.\r\n<\/a>Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z. Nat Commun<\/i>. 2013;4:1868.<\/p>\r\n

Na\u00efve\u00a0adult stem cells\u00a0from\u00a0patients\u00a0with\u00a0Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo.\r\n<\/a>Wenzel V, Roedl D, Gabriel D, Gordon LB, Herlyn M, Schneider R, Ring J, Djabali K.\r\nBiol Open.<\/i> 2012 Jun 15;1(6):516-26. Epub 2012 Apr 16.<\/p>\r\n

Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition.<\/a>\r\nMarji J, O'Donoghue SI, McClintock D, Satagopam VP, Schneider R, Ratner D, Worman HJ, Gordon LB, Djabali K. PLoS One<\/em>. 2010 Jun 15;5(6):e11132.<\/p>\r\n\r\n\r\n

\r\n

<\/a>PSADFN257<\/strong><\/p>\r\nA\u00a0Cell-Intrinsic\u00a0Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.\r\n<\/a>Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S.\u00a0Cell Rep<\/em>. 2018 Feb 20;22(8):2006-2015.\r\n\r\n

\r\n

<\/a>PSFDFN319<\/strong><\/p>\r\n

Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells.<\/a>\r\nCao K, Graziotto JJ, Blair CD, Mazzulli JR, Erdos MR, Krainc D, Collins FS. Sci Transl Med.<\/em> 2011 Jun 29;3(89):89ra58.<\/p>\r\n\r\n\r\n

\r\n

<\/a>PSMDFN320<\/strong><\/p>\r\n

Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells.<\/a>\r\nCao K, Graziotto JJ, Blair CD, Mazzulli JR, Erdos MR, Krainc D, Collins FS. Sci Transl Med.<\/em> 2011 Jun 29;3(89):89ra58.<\/p>\r\n\r\n\r\n

\r\n

<\/a>PSADFN327<\/strong><\/p>\r\n

A\u00a0Cell-Intrinsic\u00a0Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.\r\n<\/a>Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S.\u00a0Cell Rep<\/em>. 2018 Feb 20;22(8):2006-2015.<\/p>\r\n\r\n\r\n

\r\n

<\/a>PSMDFN346<\/strong><\/p>\r\nA\u00a0Cell-Intrinsic\u00a0Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.\r\n<\/a>Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S.\u00a0Cell Rep<\/em>. 2018 Feb 20;22(8):2006-2015.\r\n\r\n

\r\n

<\/a>PSADFN392<\/strong><\/p>\r\nA\u00a0Cell-Intrinsic\u00a0Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.\r\n<\/a>Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S.\u00a0Cell Rep<\/em>. 2018 Feb 20;22(8):2006-2015.\r\n\r\n

\r\n

<\/a>HGALBV009<\/strong><\/p>\r\n

Stem cell depletion in Hutchinson-Gilford progeria syndrome.<\/a>\r\nRosengardten Y, McKenna T, Grochov\u00e1 D, Eriksson M. Aging Cell.<\/em> 2011 Dec;10(6):1011-20. Epub 2011 Oct 11.<\/p>\r\n

Low and high expressing alleles of the LMNA gene: implications for laminopathy disease development.<\/a>\r\nRodr\u00edguez S, Eriksson M. PLoS One.<\/em> 2011;6(9):e25472. Epub 2011 Sep 29.<\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGMLBV010<\/strong><\/p>\r\n

Stem cell depletion in Hutchinson-Gilford progeria syndrome.<\/a>\r\nRosengardten Y, McKenna T, Grochov\u00e1 D, Eriksson M. Aging Cell.<\/em> 2011 Dec;10(6):1011-20. Epub 2011 Oct 11.<\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGALBV011<\/strong><\/p>\r\n

Low and high expressing alleles of the LMNA gene: implications for laminopathy disease development.<\/a>\r\nRodr\u00edguez S, Eriksson M. PL<\/em>oS One.<\/em> 2011;6(9):e25472. Epub 2011 Sep 29.<\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGMLBV013<\/strong><\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGFLBV021<\/strong><\/p>\r\n

Stem cell depletion in Hutchinson-Gilford progeria syndrome.<\/a>\r\nRosengardten Y, McKenna T, Grochov\u00e1 D, Eriksson M. Aging Cell.<\/em> 2011 Dec;10(6):1011-20. Epub 2011 Oct 11.<\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGMLBV023<\/strong><\/p>\r\n

Stem cell depletion in Hutchinson-Gilford progeria syndrome.<\/a>\r\nRosengardten Y, McKenna T, Grochov\u00e1 D, Eriksson M. Aging Cell.<\/em> 2011 Dec;10(6):1011-20. Epub 2011 Oct 11.<\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGFLBV031<\/strong><\/p>\r\n

Stem cell depletion in Hutchinson-Gilford progeria syndrome.<\/a>\r\nRosengardten Y, McKenna T, Grochov\u00e1 D, Eriksson M. Aging Cell.<\/em> 2011 Dec;10(6):1011-20. Epub 2011 Oct 11.<\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGFLBV050<\/strong><\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGALBV057<\/strong><\/p>\r\n

Stem cell depletion in Hutchinson-Gilford progeria syndrome.<\/a>\r\nRosengardten Y, McKenna T, Grochov\u00e1 D, Eriksson M. Aging Cell.<\/em> 2011 Dec;10(6):1011-20. Epub 2011 Oct 11.<\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGMLBV058<\/strong><\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGSLBV059<\/strong><\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.\u00a0<\/strong><\/p>\r\n\r\n\r\n

\r\n

\u00a0 <\/a>HGMLBV066<\/strong><\/p>\r\n

Stem cell depletion in Hutchinson-Gilford progeria syndrome.<\/a>\r\nRosengardten Y, McKenna T, Grochov\u00e1 D, Eriksson M. Aging Cell.<\/em> 2011 Dec;10(6):1011-20. Epub 2011 Oct 11.<\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGFLBV067<\/strong><\/p>\r\n

Stem cell depletion in Hutchinson-Gilford progeria syndrome.<\/a>\r\nRosengardten Y, McKenna T, Grochov\u00e1 D, Eriksson M. Aging Cell.<\/em> 2011 Dec;10(6):1011-20. doi: 10.1111\/j.1474-9726.2011.00743.x. Epub 2011 Oct 11.<\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\r\n\r\n\r\n

\r\n

<\/a><\/a>HGALBV071<\/strong><\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGMLBV081<\/strong><\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. Epub 2003 Apr 25.<\/p>\r\n\r\n\r\n

\r\n

<\/a>HGFLBV082<\/strong><\/p>\r\n

Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.<\/a>\r\nEriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature<\/em>. 2003 May 15;423(6937):293-8. 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