{"id":1868,"date":"2017-05-09T19:35:04","date_gmt":"2017-05-09T19:35:04","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?page_id=1868"},"modified":"2023-09-22T10:33:55","modified_gmt":"2023-09-22T14:33:55","slug":"workshop-2016","status":"publish","type":"page","link":"https:\/\/www.progeriaresearch.org\/zh\/workshop-2016\/","title":{"rendered":"\u7814\u8ba8\u4f1a 2016"},"content":{"rendered":"

2016 \u5e74 5 \u6708 2 \u65e5\u81f3 4 \u65e5\uff1b\u9a6c\u8428\u8bf8\u585e\u5dde\u5251\u6865<\/strong><\/p>\n

173 \u540d\u7814\u7a76\u4eba\u5458\u3001\u4e34\u5e8a\u533b\u751f\u548c\u4e13\u5bb6<\/b> \u65e9\u8870\u75c7\u9886\u57df\u7684\u4e13\u5bb6\u9f50\u805a\u9a6c\u8428\u8bf8\u585e\u5dde\u5251\u6865\u5e02\u7687\u5bb6\u7d22\u5c3c\u65af\u5854\u9152\u5e97\u53ca\u4f1a\u8bae\u4e2d\u5fc3\uff0c\u53c2\u52a0\u65e9\u8870\u75c7\u7814\u7a76\u57fa\u91d1\u4f1a\u7b2c\u516b\u6b21\u65e5<\/sup>\u00a0\u56fd\u9645\u79d1\u5b66\u7814\u8ba8\u4f1a\uff1a\u8de8\u8d8a\u684c\u5b50\uff0c\u73af\u6e38\u5168\u7403\u3002\u00a0 25<\/b> \u6f14\u8bb2\u8005\u548c 46<\/b> \u6d77\u62a5\u5c55\u793a\u6765\u81ea 14<\/b> \u5404\u56fd\u5c55\u793a\u4e86\u91cd\u8981\u7684\u79d1\u5b66\u53d1\u73b0\uff0c\u4ecb\u7ecd\u4e86\u5c06\u57fa\u7840\u7814\u7a76\u8f6c\u5316\u4e3a\u6f5c\u5728\u6cbb\u7597\u65b9\u6cd5\u7684\u8fdb\u5c55\uff0c\u5e76\u542f\u53d1\u4e86\u7814\u7a76\u754c\u548c\u533b\u5b66\u754c\u4e4b\u95f4\u7684\u672a\u6765\u5408\u4f5c\u3002\u968f\u7740\u7814\u7a76\u4eba\u5458\u548c\u4e34\u5e8a\u533b\u751f\u5171\u540c\u52aa\u529b\u5bfb\u627e\u6cbb\u7597\u65e9\u8870\u75c7\u7684\u65b9\u6cd5\u5e76\u63ed\u5f00\u8870\u8001\u548c\u8870\u8001\u75be\u75c5\u7684\u5965\u79d8\uff0c\u5de5\u4f5c\u7684\u5e7f\u5ea6\u548c\u8303\u56f4\u6bcf\u5e74\u90fd\u5728\u6269\u5927\u3002<\/p>\n

\"\"

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\u4f1a\u8bae\u8bae\u7a0b\u4e00\u89c8<\/b>:<\/p>\n

    \n
  • \u65e9\u8870\u75c7\u513f\u7ae5\u53ca\u5176\u7236\u6bcd\uff1a\u5e7c\u513f\u548c\u9752\u5c11\u5e74<\/li>\n
  • \u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u548c\u751f\u7269\u6807\u5fd7\u7269\u53d1\u73b0<\/li>\n
  • \u65b0\u7684\u836f\u7269\u5e72\u9884<\/li>\n
  • HGPS \u4e0e\u8870\u8001\u7684\u5206\u5b50\u548c\u7ec6\u80de\u673a\u5236<\/li>\n
  • \u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u9662\u957f Francis S. Collins \u53d1\u8868\u6f14\u8bb2<\/li>\n
  • \u65b0\u5174\u7597\u6cd5<\/li>\n
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    PRF \u6388\u4e88 Frank Rothman \u535a\u58eb\u8363\u8a89\uff1a<\/b><\/p>\n

    <\/p>\n

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    \"\"

    Bill\u3001Tina\u3001Ian \u548c Meghan Waldron\uff1bLaura \u548c Zoey Penny\uff1bHeather Ryan \u548c Carly Kudzia<\/p><\/div>\n

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    Leslie Gordon \u533b\u5b66\u535a\u58eb\uff08\u7f8e\u56fd\u5e03\u6717\u5927\u5b66\u963f\u5c14\u73c0\u7279\u533b\u5b66\u9662\u6ce2\u58eb\u987f\u513f\u7ae5\u533b\u9662\u65e9\u8870\u75c7\u7814\u7a76\u57fa\u91d1\u4f1a\uff09\u4ecb\u7ecd\u4e86\u5168\u4f53\u4f1a\u8bae\u53d1\u8a00\u4eba Vicente Andr\u00e9s \u535a\u58eb\uff08\u897f\u73ed\u7259\u56fd\u5bb6\u5fc3\u8840\u7ba1\u7814\u7a76\u4e2d\u5fc3 (CNIC)\uff09\uff0c\u4ed6\u96c4\u8fa9\u5730\u8bb2\u8ff0\u4e86\u5177\u6709\u91cc\u7a0b\u7891\u610f\u4e49\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u6210\u679c\uff0c\u8fd9\u4e9b\u6210\u679c\u5df2\u4fc3\u6210\u4e86\u513f\u7ae5\u4e34\u5e8a\u8bd5\u9a8c\u3002\u4ed6\u6307\u51fa\uff0c\u8fc4\u4eca\u4e3a\u6b62\uff0c\u65e9\u8870\u75c7\u513f\u7ae5\u7684\u4e34\u5e8a\u83b7\u76ca\u4e0d\u5927\uff0c\u5e76\u5f3a\u8c03\u7814\u7a76\u4eba\u5458\u5fc5\u987b\u7ee7\u7eed\u8fdb\u884c\u57fa\u7840\u548c\u533b\u5b66\u7814\u7a76\uff0c\u4ee5\u627e\u5230\u66f4\u6709\u6548\u7684\u7597\u6cd5\u6765\u6cbb\u7597\u548c\u6cbb\u6108\u65e9\u8870\u75c7\u3002<\/p>\n

    \u7b2c\u4e8c\u5929\u4ee5\u201cHGPS \u7684\u4e34\u5e8a\u7ed3\u679c\u548c\u751f\u7269\u6807\u5fd7\u7269\u53d1\u73b0\u201d\u4e3a\u4e3b\u9898\u7684\u4f1a\u8bae\u5f00\u59cb\u3002Leslie Gordon \u535a\u58eb\u62c9\u5f00\u4e86\u4f1a\u8bae\u7684\u5e8f\u5e55\uff0c\u4ed6\u6982\u8ff0\u4e86 HGPS \u75be\u75c5\u7684\u81ea\u7136\u53f2\u4ee5\u53ca\u6ce2\u58eb\u987f\u513f\u7ae5\u533b\u9662\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4ee4\u4eba\u9f13\u821e\u7684\u7ed3\u679c\u3002Ashwin Prakash \u535a\u58eb\uff08\u7f8e\u56fd\u6ce2\u58eb\u987f\u513f\u7ae5\u533b\u9662\uff09\u548c Brian Snyder \u535a\u58eb\uff08\u7f8e\u56fd\u54c8\u4f5b\u533b\u5b66\u9662\u6ce2\u58eb\u987f\u513f\u7ae5\u533b\u9662\uff09\u4ecb\u7ecd\u4e86\u4ed6\u4eec\u5728\u4e34\u5e8a\u8bd5\u9a8c\u5de5\u4f5c\u4e2d\u5728\u5fc3\u810f\u75c5\u5b66\u548c\u808c\u8089\u9aa8\u9abc\u8868\u73b0\u65b9\u9762\u7684\u53d1\u73b0\u3002Monica Kleinman \u535a\u58eb\uff08\u7f8e\u56fd\u6ce2\u58eb\u987f\u513f\u7ae5\u533b\u9662\uff09\u4ecb\u7ecd\u4e86\u4e09\u8054\u7597\u6cd5\u8bd5\u9a8c\u7ed3\u679c\u3002Zhongjun Zhou \u535a\u58eb\uff08\u9999\u6e2f\u5927\u5b66\uff09\u4ecb\u7ecd\u4e86\u4ed6\u7684\u8bd5\u70b9\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8be5\u8bd5\u9a8c\u4f7f\u7528\u767d\u85dc\u82a6\u9187\u4f5c\u4e3a HGPS \u7684\u6f5c\u5728\u65b0\u6cbb\u7597\u836f\u7269 - \u4ed6\u7684\u7ed3\u679c\u5c1a\u5f85\u786e\u5b9a\u3002\u4f1a\u8bae\u7ee7\u7eed\u8fdb\u884c\uff0cMarsha Moses \u535a\u58eb\uff08\u7f8e\u56fd\u54c8\u4f5b\u5927\u5b66\u6ce2\u58eb\u987f\u513f\u7ae5\u533b\u9662\uff09\u4ecb\u7ecd\u4e86\u751f\u7269\u6807\u5fd7\u7269\u65b9\u9762\u7684\u6fc0\u52a8\u4eba\u5fc3\u7684\u5de5\u4f5c - \u4e00\u79cd\u4f7f\u7528\u975e\u4fb5\u5165\u6027\u65b9\u6cd5\u6d4b\u8bd5\u6cbb\u7597\u662f\u5426\u6709\u6548\u7684\u65b9\u6cd5\u3002\u4e0a\u5348\uff0cJes\u00fas V\u00e1zquez \u535a\u58eb\uff08\u897f\u73ed\u7259 CNIC\uff09\u4ecb\u7ecd\u4e86\u4e00\u79cd\u65b0\u6280\u672f\u7684\u5f00\u53d1\u60c5\u51b5\uff0c\u8be5\u6280\u672f\u7528\u4e8e\u5b9a\u91cf\u6d4b\u5b9a\u8840\u6db2\u4e2d\u5c42\u86cb\u767d A \u548c\u65e9\u8001\u86cb\u767d\u7684\u79ef\u7d2f\u3002<\/p>\n

    \u4e0b\u5348\u7684\u4f1a\u8bae\u7ee7\u7eed\u8ba8\u8bba HGPS \u548c\u8870\u8001\u6a21\u578b\u4e2d\u7684\u836f\u7269\u5e72\u9884\u3002Brian Kennedy \u535a\u58eb\uff08\u7f8e\u56fd\u5df4\u514b\u7814\u7a76\u6240\uff09\u4ecb\u7ecd\u4e86\u767d\u85dc\u82a6\u9187\u548c\u96f7\u5e15\u9709\u7d20\u7684\u5c0f\u9f20\u7814\u7a76\u7ed3\u679c\uff0cFernando Osorio \u535a\u58eb\uff08\u897f\u73ed\u7259\u5965\u7ef4\u8036\u591a\u5927\u5b66\uff09\u7814\u7a76\u4e86\u5c0f\u9f20\u7684 NF-kB \u4fe1\u53f7\u4f20\u5bfc\uff0c\u5f97\u51fa\u7ed3\u8bba\uff0cDOT1L \u662f HGPS \u6cbb\u7597\u7684\u6f5c\u5728\u65b0\u9776\u70b9\u3002Dudley Lamming \u535a\u58eb\uff08\u7f8e\u56fd\u5a01\u65af\u5eb7\u661f\u5927\u5b66\u9ea6\u8fea\u900a\u5206\u6821\uff09\u4ecb\u7ecd\u4e86\u4f4e\u86cb\u767d\u996e\u98df\u53ef\u4ee5\u663e\u8457\u964d\u4f4e\u96f7\u5e15\u9709\u7d20\u6cbb\u7597\u9776\u5411\u7684\u86cb\u767d\u6fc0\u9176 mTORC1 \u4e14\u4e0d\u4f1a\u4ea7\u751f\u76f8\u540c\u7684\u8d1f\u9762\u526f\u4f5c\u7528\u3002Claudia Cavadas \u535a\u58eb\uff08\u8461\u8404\u7259\u79d1\u82f1\u5e03\u62c9\u5927\u5b66\uff09\u5c55\u793a\u4e86 NPY \u633d\u6551 HGPS \u7ec6\u80de\u4e2d\u7ec6\u80de\u8870\u8001\u7684\u51e0\u4e2a\u7279\u5f81\u7684\u6709\u5e0c\u671b\u7684\u7ed3\u679c\uff0cDelphine Larrieu \u535a\u58eb\uff08\u82f1\u56fd\u5251\u6865\u5927\u5b66\uff09\u4ecb\u7ecd\u4e86\u4ee4\u4eba\u5174\u594b\u7684\u53d1\u73b0\uff0c\u8868\u660e Remodelin \u548c NAT10 \u6291\u5236\u5bf9 HGPS \u5c0f\u9f20\u6709\u663e\u8457\u6539\u5584\u3002<\/p>\n

    \u7b2c\u4e00\u5929\u548c\u7b2c\u4e8c\u5929\u7684\u665a\u4e0a\u4ee5\u6d77\u62a5\u5c55\u793a\u7ed3\u675f\uff0c\u4e3b\u9898\u6db5\u76d6\u6cbb\u7597\u7684\u65b0\u6f5c\u5728\u6cbb\u7597\u9776\u70b9\uff08\u5982 Gherlin \u548c JH4\uff09\u3001\u6f5c\u5728\u7684\u751f\u7269\u6807\u5fd7\u7269\u548c\u7528\u4e8e\u786e\u5b9a\u6cbb\u7597\u6548\u679c\u7684\u975e\u4fb5\u5165\u6027\u6d4b\u91cf\u6280\u672f\u3001\u975e\u5178\u578b\u65e9\u8870\u75c7\u60a3\u8005\u7684\u65b0\u53d1\u73b0\u4ee5\u53ca\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6700\u65b0\u53d1\u73b0\u3002<\/p>\n

    \u6807\u9898<\/h1>\n
      \n
    • PRF \u6570\u636e\u548c\u65e9\u8870\u75c7\u7814\u7a76\u57fa\u91d1\u4f1a\u9879\u76ee<\/li>\n
    • \u4e24\u79cd\u65e9\u8870\u86cb\u767d\u4ea7\u751f\u4eba\u7fa4\u7684\u4f53\u7ec6\u80de\u5d4c\u5408\u4f53<\/li>\n
    • \u7a81\u53d8\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u8840\u6d46\u751f\u7269\u6807\u5fd7\u7269\u7684\u591a\u91cd\u7b5b\u9009<\/li>\n
    • \u751f\u957f\u7d20\u91ca\u653e\u80bd\u589e\u5f3a\u65e9\u8870\u86cb\u767d\u6e05\u9664\u5e76\u633d\u6551\u4eba\u7c7b\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7ec6\u80de\u7684\u8870\u8001\u8868\u578b<\/li>\n
    • \u65e9\u8870\u75c7\u7814\u7a76\u57fa\u91d1\u4f1a\u7ec6\u80de\u548c\u7ec4\u7ec7\u5e93\u53ca\u8bca\u65ad\u9879\u76ee<\/li>\n
    • \u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u60a3\u8005\u7684\u9f88\u4e0b\u5fae\u751f\u7269\u8c31\uff1a\u4f7f\u7528\u4eba\u7c7b\u53e3\u8154\u5fae\u751f\u7269\u8bc6\u522b\u5fae\u9635\u5217\u4e0e\u7259\u5468\u5065\u5eb7\u548c\u7259\u5468\u75be\u75c5\u8fdb\u884c\u6bd4\u8f83<\/li>\n
    • \u65e9\u8870\u75c7\u8111\u78c1\u5171\u632f\u6210\u50cf\u7684\u201c\u5b57\u6bcd\u6c64\u201d<\/li>\n
    • \u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u5185\u76ae\u8868\u578b<\/li>\n
    • \u8fc1\u79fb\u6027\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u7684\u7740\u4e1d\u7c92\u5b9a\u5411\u548c\u6838\u8fd0\u52a8\u53d7\u635f\u662f\u8fc7\u65e9\u548c\u6b63\u5e38\u8870\u8001\u7684\u7279\u5f81<\/li>\n
    • Progerin \u548c Lamin-A \u5728 iPSC \u884d\u751f\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u4e2d\u5747\u7b49\u5730\u78f7\u9178\u5316\uff1a\u901a\u8fc7\u7cbe\u7ec6\u5207\u9664\u548c\u6bd4\u5bf9\u8d28\u8c31 (FEA-MS) \u8fdb\u884c\u5b9a\u91cf<\/li>\n
    • \u7ecf\u5178 Wnt-\u03b2-catenin \u4fe1\u53f7\u901a\u8def\u5728\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u6210\u9aa8\u5206\u5316\u548c\u9aa8\u8d28\u91cf\u4e2d\u7684\u4f5c\u7528\u7814\u7a76<\/li>\n
    • \u4e00\u79cd\u65b0\u578b\u5c42\u86cb\u767dA\/C<\/li>\n
    • \u4f9d\u7ef4\u83ab\u53f8\u6539\u5584\u5c42\u86cb\u767d\u75c5\u7ec6\u80de\u7684\u8868\u578b<\/li>\n
    • \u65e9\u8870\u75c7\u4e34\u5e8a\u8bd5\u9a8c\u65b9\u6848\u548c\u6982\u8ff0<\/li>\n
    • \u039435 \u548c \u039450 \u7f3a\u5931\u7834\u574f\u4e86 O-GlcNAc \u4fee\u9970\u7684 Lamin A \u5c3e\u90e8\u7279\u6709\u7684\u201c\u6700\u4f73\u70b9\u201d\uff1a\u5bf9 Lamin A \u4ee3\u8c22\uff08\u5931\uff09\u8c03\u8282\u7684\u5f71\u54cd<\/li>\n
    • \u901a\u8fc7\u5916\u663e\u5b50\u7ec4\u6d4b\u5e8f\u9274\u5b9a\u975e\u5178\u578b\u65e9\u8870\u75c7\u7684\u81f4\u75c5\u7a81\u53d8<\/li>\n
    • \u5f00\u53d1\u4e00\u79cd\u7528\u4e8e\u5b9a\u91cf\u57fa\u8d28\u4e2d\u65e9\u8001\u86cb\u767d\u7684\u8d85\u654f\u514d\u75ab\u6d4b\u5b9a\u6cd5<\/li>\n
    • \u65e9\u8870\u75c7\u4e2d\u7684\u52a8\u8109\u7ca5\u6837\u786c\u5316\uff1a\u4ece\u5177\u6709\u666e\u904d\u6027\u548c VSMC \u7279\u5f02\u6027\u65e9\u8870\u86cb\u767d\u8868\u8fbe\u7684\u65b0\u5c0f\u9f20\u6a21\u578b\u4e2d\u83b7\u5f97\u7684\u89c1\u89e3<\/li>\n
    • \u9610\u660e\u4eba\u7c7b ZMPSTE24 \u7684\u86cb\u767d\u6c34\u89e3\u6d3b\u6027\u548c\u75be\u75c5\u7a81\u53d8<\/li>\n
    • JH4 \u884d\u751f\u5316\u5b66\u54c1\u6cbb\u7597\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u4e34\u5e8a\u524d\u5206\u6790<\/li>\n
    • \u7ef4\u751f\u7d20 D \u53ef\u964d\u4f4e Progerin \u8868\u8fbe\u5e76\u6539\u5584 HGPS \u7ec6\u80de\u7f3a\u9677<\/li>\n
    • \u6297\u6c27\u5316 NRF2 \u901a\u8def\u5728\u8fc7\u65e9\u8870\u8001\u4e2d\u7684\u6291\u5236<\/li>\n
    • \u9798\u8102\u4ee3\u8c22\u7269\u548c HGPS \u8868\u578b<\/li>\n
    • \u4eba\u7c7b\u7aef\u7c92\u9176mRNA\u5bf9\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u60a3\u8005\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u6cbb\u7597\u4f5c\u7528<\/li>\n
    • \u975e\u5178\u578b\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81<\/li>\n
    • \u65e9\u8870\u75c7\u7684\u773c\u79d1\u8868\u73b0<\/li>\n
    • \u65e9\u8870\u75c7\u4e2d\u7684\u6708\u7ecf\u521d\u6f6e<\/li>\n
    • \u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7ec6\u80de\u7684\u8fc7\u65e9\u8870\u8001\u662f\u7531\u4e8e\u590d\u5236\u538b\u529b\u5bfc\u81f4 p53 \u6fc0\u6d3b\u6240\u81f4<\/li>\n
    • microRNA-29 \u7684\u8bf1\u5bfc\u5bfc\u81f4\u5c0f\u9f20\u51fa\u73b0\u65e9\u8870\u8868\u578b<\/li>\n
    • \u4e00\u5c0f\u7fa4\u60a3\u6709\u5178\u578b\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u513f\u7ae5\u7684\u7c97\u5927\u548c\u7cbe\u7ec6\u8fd0\u52a8\u8868\u73b0<\/li>\n
    • \u5fae\u56fe\u6848\u5316\u57fa\u8d28\u52a0\u901f\u75c5\u7406\u6027\u5e73\u6ed1\u808c\u7ec6\u80de\u8001\u5316<\/li>\n
    • \u65e9\u8001\u7d20\u6c34\u5e73\u4f4e\u4f1a\u5bfc\u81f4\u8102\u80aa\u7ec4\u7ec7\u968f\u65f6\u95f4\u6d41\u5931<\/li>\n
    • \u7531\u4e8e\u5c42\u86cb\u767d A \u5377\u66f2\u87ba\u65cb\u7ed3\u6784\u57df\u7a81\u53d8\u5bfc\u81f4\u7684\u975e\u5178\u578b\u65e9\u8870\u7efc\u5408\u5f81<\/li>\n
    • \u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u60a3\u8005\u7279\u5b9a\u4e0b\u80a2 (LE) \u6d3b\u52a8\u8303\u56f4 (ROM) \u53d7\u635f\u4e0e\u8eab\u4f53\u673a\u80fd\u548c\u5e74\u9f84\u7684\u5173\u7cfb<\/li>\n
    • \u7aef\u7c92\u86cb\u767d AKTIP \u4e0e\u5c42\u86cb\u767d\u7684\u529f\u80fd\u548c\u62d3\u6251\u76f8\u4e92\u4f5c\u7528<\/li>\n
    • \u6cd5\u5462\u57fa\u5316\u6291\u5236\u5242\u5bf9\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u60a3\u8005\u751f\u5b58\u671f\u5f71\u54cd\u7684\u6700\u65b0\u8fdb\u5c55<\/li>\n
    • \u6838\u819c\u86cb\u767d Luma \u5bf9\u5fc3\u810f\u6b63\u5e38\u529f\u80fd\u800c\u8a00\u5e76\u975e\u5fc5\u4e0d\u53ef\u5c11<\/li>\n
    • \u0394133p53 \u540c\u5de5\u9176\u4f5c\u4e3a\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u65b0\u578b\u6cbb\u7597\u9776\u70b9<\/li>\n
    • \u6d88\u9664 Prelamin A \u4e2d ZMPSTE24 \u5207\u5272\u4f4d\u70b9\u7684\u7a81\u53d8\u5bfc\u81f4\u65e9\u8870\u75c7<\/li>\n
    • \u4f4e NO\uff1a\u6b63\u5e38\u8870\u8001\u548c\u65e9\u8870\u75c7\u7684\u5171\u540c\u9014\u5f84\uff1f\u4eba\u4f53\u76ae\u80a4\u5fae\u751f\u7269\u7fa4\u4e2d\u7684\u6c28\u6c27\u5316\u7ec6\u83cc\u4f5c\u4e3a\u6297\u708e\u5242<\/li>\n
    • \u65e9\u8870\u75c7\u548c\u76ae\u80a4\u75c5\u5b66\uff1a\u4e00\u4e2a\u88ab\u9057\u5fd8\u7684\u6545\u4e8b\uff1f<\/li>\n
    • \u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u8f6c\u57fa\u56e0\u5c0f\u9f20\u51fa\u751f\u540e\u65e9\u671f\u89d2\u8d28\u5f62\u6210\u7ec6\u80de\u3001\u6210\u9aa8\u7ec6\u80de\u548c\u9aa8\u7ec6\u80de\u7684\u8f6c\u5f55\u5206\u6790<\/li>\n
    • G608G \u65e9\u8870\u75c7\u5c0f\u9f20\u6a21\u578b\u7684\u6cbb\u7597\u9aa8\u9abc\u7597\u6548\u6bd4\u8f83<\/li>\n
    • \u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u7684\u7259\u9f7f\u548c\u9885\u9762\u8868\u73b0\uff1a\u4e00\u9879\u7eb5\u5411\u7814\u7a76<\/li>\n
    • \u5bf9\u6bd4\u589e\u5f3a\u5fae CT (CEuCT) \u7528\u4e8e\u76d1\u6d4b G608G \u65e9\u8870\u75c7\u5c0f\u9f20\u6a21\u578b\u4e2d\u7684\u8f6f\u9aa8\u7ed3\u6784\u7279\u6027\u548c\u751f\u5316\u6210\u5206<\/li>\n
    • \u5229\u7528\u8bf1\u5bfc\u6027\u591a\u80fd\u5e72\u7ec6\u80de\u7b5b\u9009\u54c8\u94a6\u68ee-\u5409\u5c14\u798f\u5fb7\u65e9\u8870\u7efc\u5408\u5f81\u836f\u7269<\/li>\n<\/ul>\n

      \u7b2c\u4e09\u5929\u6df1\u5165\u63a2\u8ba8\u4e86\u7ec6\u80de\u751f\u7269\u5b66\u548c\u751f\u7406\u5b66\u3002\u4e0a\u5348\u7684\u4f1a\u8bae\u9898\u4e3a\u201cHGPS \u548c\u8870\u8001\u4e2d\u7684\u5206\u5b50\u548c\u7ec6\u80de\u673a\u5236\u201d\uff0c\u7531 Maria Eriksson \u535a\u58eb\uff08\u745e\u5178\u5361\u7f57\u7433\u65af\u5361\u533b\u5b66\u9662\uff09\u4e3b\u6301\u3002Robert Goldman \u535a\u58eb\uff08\u7f8e\u56fd\u897f\u5317\u5927\u5b66\uff09\u9996\u5148\u7814\u7a76\u4e86\u6838\u5c42\u4e2d\u7684\u6838\u5c42\u86cb\u767d\u5f02\u6784\u4f53\u4ee5\u53ca 3D \u8d85\u5206\u8fa8\u7387\u663e\u5fae\u955c\u6280\u672f\u7684\u5f00\u53d1\u3002<\/p>\n

      \"\"

      \u7814\u8ba8\u4f1a\u7ec4\u7ec7\u8005 Frank Rothman \u535a\u58eb\u63d0\u51fa\u4e86\u4e00\u4e2a\u95ee\u9898\u3002<\/p><\/div>\n

      \u51ef\u745f\u7433\u00b7\u5a01\u5c14\u900a\u535a\u58eb\uff08\u7f8e\u56fd\u7ea6\u7ff0\u970d\u666e\u91d1\u65af\u533b\u5b66\u9662\uff09\u4ecb\u7ecd\u4e86\u5979\u5bf9\u9176 OGT \u7684\u7814\u7a76\uff0c\u8be5\u9176\u53ef\u5411\u9776\u86cb\u767d\u4e2d\u6dfb\u52a0\u7cd6\u5206\u5b50\uff0c\u5e76\u4e14\u5bf9\u6240\u6709\u7ec6\u80de\u90fd\u81f3\u5173\u91cd\u8981\u3002\u4e54\u51e1\u5a1c\u00b7\u62c9\u5766\u9f50\u535a\u58eb\uff08\u610f\u5927\u5229 CNR \u5206\u5b50\u9057\u4f20\u5b66\u7814\u7a76\u6240\uff09\u4ecb\u7ecd\u4e86\u5979\u7684\u7814\u7a76\u6210\u679c\uff1a\u89c6\u9ec4\u9178\u548c\u96f7\u5e15\u9709\u7d20\u53ef\u589e\u52a0\u5c42\u86cb\u767d A \u4e0e\u524d\u5c42\u86cb\u767d A \u7684\u6bd4\u4f8b\uff0c\u4ece\u800c\u633d\u6551\u7ec6\u80de\u4e2d\u7684 DNA \u4fee\u590d\u673a\u5236\u3002\u533b\u5b66\u535a\u58eb\u3001\u54f2\u5b66\u535a\u58eb\u6770\u62c9\u5c14\u591a\u00b7\u8d39\u8d1d\u5c14\uff08\u52a0\u62ff\u5927\u8499\u7279\u5229\u5c14\u5927\u5b66\uff09\u4e00\u76f4\u5728\u7814\u7a76 HGPS \u7ec6\u80de\u4e2d\u5185\u6e90\u6027\u7a81\u53d8\u5c42\u86cb\u767d A \u7684\u95f4\u671f\u4e1d\u6c28\u9178 22 \u78f7\u9178\u5316\uff0c\u800c\u79d1\u6797\u00b7\u65af\u56fe\u5c14\u7279\u535a\u58eb\uff08\u65b0\u52a0\u5761\u533b\u5b66\u751f\u7269\u5b66\u7814\u7a76\u6240\uff09\u5219\u4e13\u6ce8\u4e8e\u7814\u7a76 SUN1\uff0c\u8fd9\u662f\u4e00\u79cd\u5f71\u54cd HGPS \u7ec6\u80de\u7684\u86cb\u767d\u8d28\u3002 Maria Eriksson \u535a\u58eb\u5728\u4f1a\u8bae\u7ed3\u675f\u65f6\u4ecb\u7ecd\u4e86\u5979\u7684\u7814\u7a76\u6210\u679c\uff0c\u8be5\u7814\u7a76\u7814\u7a76\u4e86\u767d\u85dc\u82a6\u9187\u5bf9 HGPS \u5c0f\u9f20\u9aa8\u9abc\u91cd\u5851\u7684\u6f5c\u5728\u6709\u76ca\u4f5c\u7528\u3002\u7b2c\u4e09\u5929\u4e0b\u5348\u7684\u4f1a\u8bae\u4e3b\u9898\u4e3a\u201c\u65b0\u5174\u7597\u6cd5\u201d\uff0c\u7531 Tom Misteli \u535a\u58eb\uff08\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\/\u7f8e\u56fd\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff09\u62c9\u5f00\u5e37\u5e55\uff0c\u4ed6\u6982\u8ff0\u4e86\u5bfb\u627e\u6f5c\u5728\u6cbb\u7597\u5019\u9009\u836f\u7269\u7684\u60c5\u51b5\u3002Francis Collins \u533b\u5b66\u535a\u58eb\u5206\u4eab\u4e86\u4f9d\u7ef4\u83ab\u53f8\u5728\u5c0f\u9f20\u7814\u7a76\u4e2d\u53d6\u5f97\u7684\u4ee4\u4eba\u9f13\u821e\u7684\u7ed3\u679c\u3002Joseph Rabinowitz \u535a\u58eb\uff08\u7f8e\u56fd\u5929\u666e\u5927\u5b66\uff09\u4ecb\u7ecd\u4e86\u57fa\u56e0\u6cbb\u7597\u7814\u7a76\u7684\u7b2c\u4e00\u6b65\u3002John Cooke \u533b\u5b66\u535a\u58eb\uff08\u7f8e\u56fd\u4f11\u65af\u987f\u536b\u7406\u516c\u4f1a\u7814\u7a76\u6240\uff09\u5728\u4f1a\u8bae\u7ed3\u675f\u65f6\u751f\u52a8\u5730\u4ecb\u7ecd\u4e86\u7aef\u7c92\u9176 RNA \u7597\u6cd5\u4f5c\u4e3a\u4e00\u79cd\u65b0\u578b\u6f5c\u5728\u7597\u6cd5\u3002<\/p>\n

      Judy Campisi \u535a\u58eb\uff08\u7f8e\u56fd\u5df4\u514b\u7814\u7a76\u6240\uff09\u3001Mark Kieran \u533b\u5b66\u535a\u58eb\uff08\u7f8e\u56fd\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u6240\uff09\u548c Francis Collins \u533b\u5b66\u535a\u58eb\u4e3b\u6301\u4e86\u4f1a\u8bae\u603b\u7ed3\u548c\u4e3b\u8981\u53d1\u73b0\uff0c\u5e76\u5e26\u5934\u5c31\u65e9\u8870\u75c7\u7814\u7a76\u7684\u672a\u6765\u5c55\u5f00\u4e86\u70ed\u70c8\u7684\u8ba8\u8bba\u3002\u4f5c\u4e3a\u4f1a\u8bae\u7684\u5b8c\u7f8e\u95ed\u5e55\u5f0f\uff0cFrancis Collins \u533b\u5b66\u535a\u58eb\u6f14\u5531\u4e86\u4ed6\u521b\u4f5c\u7684\u6b4c\u66f2\uff0c \u6562\u4e8e\u68a6\u60f3<\/i>, inspired by a conversation he had with Sam Berns at TEDMED 2012.[vc_column width=”1\/6″][vc_custom_heading text=”Attendees” font_container=”tag:h1|text_align:right” use_theme_fonts=”yes”]<\/p>\n\n\n\n\n\n\n\n\n\n
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      May 2-4, 2016; Cambridge, MA 173 researchers, clinicians and experts in the field of Progeria gathered at the Royal Sonesta Hotel & Conference Center in Cambridge, MA for the Progeria Research Foundation\u2019s 8th\u00a0International Scientific Workshop: Across the Table, Around the Globe.\u00a0 25 speakers and 46 poster presentations from 14 countries showcased important scientific findings, presented […]<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-1868","page","type-page","status-publish","hentry"],"yoast_head":"\nworkshop 2016 | The Progeria Research Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.progeriaresearch.org\/zh\/workshop-2016\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"workshop 2016 | The Progeria Research Foundation\" \/>\n<meta property=\"og:description\" content=\"May 2-4, 2016; Cambridge, MA 173 researchers, clinicians and experts in the field of Progeria gathered at the Royal Sonesta Hotel & Conference Center in Cambridge, MA for the Progeria Research Foundation\u2019s 8th\u00a0International Scientific Workshop: Across the Table, Around the Globe.\u00a0 25 speakers and 46 poster presentations from 14 countries showcased important scientific findings, presented […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.progeriaresearch.org\/zh\/workshop-2016\/\" \/>\n<meta property=\"og:site_name\" content=\"The Progeria Research Foundation\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ProgeriaResearch\/\" \/>\n<meta property=\"article:modified_time\" content=\"2023-09-22T14:33:55+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.progeriaresearch.org\/assets\/images\/medical_images\/ACROSS_AROUND_Nihal-(2).jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@Progeria\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"15 \u5206\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.progeriaresearch.org\/it\/workshop-2016\/\",\"url\":\"https:\/\/www.progeriaresearch.org\/it\/workshop-2016\/\",\"name\":\"workshop 2016 | The Progeria Research Foundation\",\"isPartOf\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/ta\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/it\/workshop-2016\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/it\/workshop-2016\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.progeriaresearch.org\/assets\/images\/medical_images\/ACROSS_AROUND_Nihal-(2).jpg\",\"datePublished\":\"2017-05-09T19:35:04+00:00\",\"dateModified\":\"2023-09-22T14:33:55+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/it\/workshop-2016\/#breadcrumb\"},\"inLanguage\":\"zh-Hans\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.progeriaresearch.org\/it\/workshop-2016\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-Hans\",\"@id\":\"https:\/\/www.progeriaresearch.org\/it\/workshop-2016\/#primaryimage\",\"url\":\"https:\/\/www.progeriaresearch.org\/assets\/images\/medical_images\/ACROSS_AROUND_Nihal-(2).jpg\",\"contentUrl\":\"https:\/\/www.progeriaresearch.org\/assets\/images\/medical_images\/ACROSS_AROUND_Nihal-(2).jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.progeriaresearch.org\/it\/workshop-2016\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.progeriaresearch.org\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Workshop 2016\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.progeriaresearch.org\/ta\/#website\",\"url\":\"https:\/\/www.progeriaresearch.org\/ta\/\",\"name\":\"The Progeria Research Foundation\",\"description\":\"For the Children \u2665 For the Cure\",\"publisher\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/ta\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.progeriaresearch.org\/ta\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"zh-Hans\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.progeriaresearch.org\/ta\/#organization\",\"name\":\"The Progeria Research Foundation\",\"url\":\"https:\/\/www.progeriaresearch.org\/ta\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-Hans\",\"@id\":\"https:\/\/www.progeriaresearch.org\/ta\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/05\/PRF_Logo_2019_optimized.png\",\"contentUrl\":\"https:\/\/www.progeriaresearch.org\/wp-content\/uploads\/2019\/05\/PRF_Logo_2019_optimized.png\",\"width\":300,\"height\":86,\"caption\":\"The Progeria Research Foundation\"},\"image\":{\"@id\":\"https:\/\/www.progeriaresearch.org\/ta\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/ProgeriaResearch\/\",\"https:\/\/x.com\/Progeria\",\"https:\/\/www.instagram.com\/progeriaresearch\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"workshop 2016 | The Progeria Research Foundation","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.progeriaresearch.org\/zh\/workshop-2016\/","og_locale":"zh_CN","og_type":"article","og_title":"workshop 2016 | The Progeria Research Foundation","og_description":"May 2-4, 2016; 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