{"id":8398,"date":"2020-11-02T18:57:17","date_gmt":"2020-11-02T23:57:17","guid":{"rendered":"https:\/\/www.progeriaresearch.org\/?p=8398"},"modified":"2022-12-09T06:43:20","modified_gmt":"2022-12-09T11:43:20","slug":"2020-workshop","status":"publish","type":"post","link":"https:\/\/www.progeriaresearch.org\/zh\/2020\/11\/02\/2020-workshop\/","title":{"rendered":"PRF\u7b2c\u5341\u5c4a\u56fd\u9645\u79d1\u5b66\u7814\u8ba8\u4f1a"},"content":{"rendered":"

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\u8d85\u8fc7 370<\/strong> \u6765\u81ea\u7684\u6ce8\u518c\u8005 30<\/strong> \u53c2\u52a0\u6211\u4eec 1 \u4e2a\u56fd\u5bb6\u82f1\u77f3<\/sup> \u6709\u53f2\u4ee5\u6765\u6700\u5927\u89c4\u6a21\u7684\u57fa\u4e8e\u7f51\u7edc\u7684\u79d1\u5b66\u4f1a\u8bae\uff01<\/h4>\n

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\u6211\u4eec\u5e0c\u671b\u60a8\u559c\u6b22\u6211\u4eec 2020 \u5e74\u56fd\u9645\u7814\u8ba8\u4f1a\u7684\u8fd9\u6bb5\u89c6\u9891\uff0c
\u201c\u63a2\u7d22\u53ef\u80fd\u6027\uff0c\u5ef6\u957f\u751f\u547d\u201d\u7f51\u7edc\u7814\u8ba8\u4f1a<\/h4>\n

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\u00a0\u4fdd\u7559\u6240\u6709\u6743\u5229\u3002\u8bf7\u52ff\u4ee5\u4efb\u4f55\u65b9\u5f0f\u4e0b\u8f7d\u3001\u590d\u5236\u3001\u5206\u53d1\u6216\u4fee\u6539\u672c\u6f14\u793a\u6587\u7a3f\u3002<\/i><\/p>\n

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\u672a\u56de\u7b54\u7684\u804a\u5929\u95ee\u9898<\/strong><\/h4>\n

[\/et_pb_text][et_pb_toggle title=”To Dr. Francis Collins: Question: From Mansoor Amiji: Dr. Collins, have you looked at the biodistribution of the PPPMO upon systemic ” open_toggle_background_color=”#f7f7f7″ closed_toggle_text_color=”#ffffff” closed_toggle_background_color=”#00b2e2″ icon_color=”#ffc15e” open_icon_color=”#ffc15e” admin_label=”Collins Q&A” _builder_version=”4.16″ _module_preset=”default” title_text_color=”#00b2e2″ title_font=”||||||||” background_color=”#ffffff” custom_margin=”||25px” custom_padding=”|50px||50px||true” border_width_all=”0px” global_colors_info=”{}”]<\/p>\n


\"\"\u56de\u7b54\uff1a<\/strong> PK\/PD \u7814\u7a76\u8868\u660e 100% \u5728\u5fc3\u810f\u3001\u4e3b\u52a8\u8109\u548c\u80be\u810f\u4e2d\u7684\u751f\u7269\u5229\u7528\u5ea6\u8f83\u9ad8\u3002\u6839\u636e\u7ec4\u7ec7\u5b66\u68c0\u67e5\u548c PK\/PD \u6570\u636e\uff0c\u80be\u810f\u662f\u552f\u4e00\u6709\u84c4\u79ef\u8ff9\u8c61\u7684\u7ec4\u7ec7\u3002\u5355\u5242\u91cf SRP-2001 \u7ed9\u836f\u8868\u660e PPMO \u8fc5\u901f\u4ece\u5fc3\u810f\u4e2d\u6e05\u9664\uff082 \u5c0f\u65f6\u5185\uff09\uff0c\u4ece\u4e3b\u52a8\u8109\u4e2d\u6e05\u9664\uff084 \u5c0f\u65f6\u5185\uff09\uff0c\u4f46\u5728\u80be\u810f\u4e2d\u6301\u7eed\u5230 48 \u5c0f\u65f6\u65f6\u95f4\u70b9\u3002\u5b9a\u91cf ddPCR \u8868\u660e\uff0c\u8fc4\u4eca\u4e3a\u6b62\u9664\u76ae\u80a4\u5916\uff0c\u6240\u6709\u6d4b\u8bd5\u7684\u7ec4\u7ec7\uff08\u4e3b\u52a8\u8109\u3001\u5fc3\u810f\u3001\u80be\u810f\u3001\u809d\u810f\u3001\u80a1\u56db\u5934\u808c\u3001\u9aa8\u9abc\uff09\u4e2d\u5747\u5b58\u5728 G608G \u9690\u853d\u526a\u63a5\u6291\u5236\u6d3b\u6027\uff0c\u5c3d\u7ba1\u6d3b\u6027\u56e0\u7ec4\u7ec7\u800c\u5f02\u3002<\/p>\n

\u5f17\u6717\u897f\u65af\u3001\u8fc8\u514b\u548c\u97e6\u6069<\/em><\/p>\n

[\/et_pb_toggle][et_pb_toggle title=”To Dr. Pinak Shah and Dr. Francesco Musumeci: Question: From RVB: Can magnesium\/calcium intake determine the degree of calcification in children with HGPS?” open_toggle_background_color=”#f7f7f7″ closed_toggle_text_color=”#ffffff” closed_toggle_background_color=”#00b2e2″ icon_color=”#ffc15e” open_icon_color=”#ffc15e” admin_label=”Shah & Musumeci Q&A” _builder_version=”4.16″ _module_preset=”default” title_text_color=”#00b2e2″ title_font=”||||||||” background_color=”#ffffff” custom_margin=”||25px” custom_padding=”|50px||50px||true” border_width_all=”0px” global_colors_info=”{}”]<\/p>\n

\"\"<\/strong>\u56de\u7b54\uff1a<\/strong>\u5173\u4e8e\u8fd9\u4e2a\u95ee\u9898\uff0c\u8bf4\u5b9e\u8bdd\uff0c\u6211\u4e0d\u77e5\u9053\u7b54\u6848\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u5178\u578b\u7684\u6210\u5e74\u4eba\u6765\u8bf4\uff0c\u6211\u4eec\u5e76\u6ca1\u6709\u5c06\u74e3\u819c\u9499\u5316\u7684\u7a0b\u5ea6\u4e0e\u9541\/\u9499\u6444\u5165\u91cf\u8054\u7cfb\u8d77\u6765\uff0c\u66f4\u4e25\u91cd\u7684\u9499\u5316\u53ef\u80fd\u662f\u7531\u5176\u4ed6\u56e0\u7d20\u9020\u6210\u7684\u3002<\/p>\n

\u76ae\u7eb3\u514b\u00b7\u6c99\u963f\u535a\u58eb<\/em><\/p>\n

 <\/p>\n

 <\/p>\n

\"\"\u56de\u7b54\uff1a <\/strong>\u6211\u540c\u610f Shah \u535a\u58eb\u7684\u89c2\u70b9\u3002HGPS \u4e2d\u74e3\u819c\u9499\u5316\u7684\u539f\u56e0\u53ef\u80fd\u4e0e\u6211\u4eec\u5728\u8001\u5e74\u60a3\u8005\u4e2d\u770b\u5230\u7684\u539f\u56e0\u4e0d\u540c\u3002\u6211\u5bf9\u9499\u548c\u9541\u4ee3\u8c22\u4e5f\u4e0d\u4e86\u89e3\u3002<\/p>\n

Francesco Musumeci \u535a\u58eb<\/em><\/p>\n

\u00a0<\/strong><\/p>\n

[\/et_pb_toggle][et_pb_toggle title=” To Dr. Vicente Andres: Question: From Andre Monteiro Da Rocha – University of Michigan: Do the mice lacking Lamin A develop DCM?” open_toggle_background_color=”#f7f7f7″ closed_toggle_text_color=”#ffffff” closed_toggle_background_color=”#00b2e2″ icon_color=”#ffc15e” open_icon_color=”#ffc15e” admin_label=”Andres Q&A” _builder_version=”4.16″ _module_preset=”default” title_text_color=”#00b2e2″ title_font=”||||||||” background_color=”#ffffff” custom_margin=”||25px” custom_padding=”|50px||50px||true” border_width_all=”0px” global_colors_info=”{}”]<\/p>\n

\"\"\u56de\u7b54\uff1a <\/strong>\u5c42\u86cb\u767d A\/C \u65e0\u6548 (\u6797\u7eb3<\/em>-\/-<\/sup>) \u5c0f\u9f20\u6a21\u578b\u4f1a\u53d1\u5c55\u4e3a\u4f34\u6709\u5fc3\u810f\u529f\u80fd\u4e27\u5931\u7684 DCM\u3002\u6b64\u5916\uff0c\u8fd9\u4e9b\u5c0f\u9f20\u8868\u73b0\u51fa\u5fc3\u810f\u4f20\u5bfc\u7f3a\u9677\u548c\u5e7f\u6cdb\u7684\u5fc3\u810f\u7ea4\u7ef4\u5316\uff0c\u5e76\u5728 5-8 \u5468\u9f84\u65f6\u8fc7\u65e9\u6b7b\u4ea1 (Auguste et al., 2018; Frock et al., 2012; Sullivan, 1999)\u3002\u7136\u800c\uff0c\u4ec5\u7f3a\u4e4f\u5c42\u86cb\u767d A (Fong et al., 2006) \u6216\u5c42\u86cb\u767d C (Coffinier et al., 2010) \u7684\u5c0f\u9f20\u6a21\u578b\u4e0d\u4f1a\u51fa\u73b0\u5fc3\u810f\u7f3a\u9677\uff0c\u5e76\u4e14\u5177\u6709\u6b63\u5e38\u7684\u5bff\u547d\u3002<\/p>\n

\u53c2\u8003\uff1a
<\/strong>Auguste, G.\u3001Gurha, P.\u3001Lombardi, R.\u3001Coarfa, C.\u3001Willerson, JT \u548c Marian, AJ (2018)\u3002 \u6291\u5236\u5fc3\u810f\u4e2d\u6fc0\u6d3b\u7684 FOXO \u8f6c\u5f55\u56e0\u5b50\u53ef\u5ef6\u957f\u6838\u7ea4\u5c42\u86cb\u767d\u75c5\u5c0f\u9f20\u6a21\u578b\u7684\u751f\u5b58\u671f<\/em>. https:\/\/doi.org\/10.1161\/CIRCRESAHA.117.312052<\/a><\/p>\n

Coffinier, C., Jung, HJ, Li, Z., Nobumori, C., Yun, UJ, Farber, EA, Davies, BS, Weinstein, MM, Yang, SH, Lammerding, J., Farahani, JN, Bentolila, LA, Fong, LG, & Young, SG (2010). \u7ed5\u8fc7\u524d\u5c42\u86cb\u767d a \u52a0\u5de5\uff0c\u76f4\u63a5\u5408\u6210\u5c42\u86cb\u767d A\uff0c\u5bfc\u81f4\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u7684\u7ec6\u80de\u6838\u7578\u5f62\uff0c\u4f46\u5728\u5c0f\u9f20\u4e2d\u672a\u68c0\u6d4b\u5230\u75c5\u7406\u3002 \u751f\u7269\u5316\u5b66\u6742\u5fd7<\/em>, 285<\/em>(27), 20818\u201320826\u3002 https:\/\/doi.org\/10.1074\/jbc.M110.128835<\/a><\/p>\n

Fong, LG, Bergo, MO, Young, SG, Fong, LG, Ng, JK, Lammerding, J., Vickers, TA, Meta, M., Cot\u00e9, N., Gavino, B., Qiao, X., Chang, SY, Young, SR, Yang, SH, Stewart, CL, Lee, RT, Bennett, CF, Bergo, MO, & Young, SG (2006). Prelamin A \u548c\u5c42\u86cb\u767d A \u4f3c\u4e4e\u5728\u6838\u5c42\u4e2d\u662f\u53ef\u6709\u53ef\u65e0\u7684\u3002 \u4e34\u5e8a\u7814\u7a76\u6742\u5fd7<\/em>, 116<\/em>(3), 743\u2013752\u3002 https:\/\/doi.org\/10.1172\/JCI27125.with<\/a><\/p>\n

Frock, RL, Chen, SC, Da, D., Frett, E., Lau, C., Brown, C., Pak, DN, Wang, Y., Muchir, A., Worman, HJ, Santana, LF, Ladiges, WC, Rabinovitch, PS, & Kennedy, BK (2012).\u5fc3\u808c\u7ec6\u80de\u7279\u5f02\u6027\u8868\u8fbe\u5c42\u86cb\u767d A \u53ef\u6539\u5584 Lmna-\/- \u5c0f\u9f20\u7684\u5fc3\u810f\u529f\u80fd\u3002 \u516c\u5171\u79d1\u5b66\u56fe\u4e66\u9986<\/em>, 7<\/em>\uff088\uff09\uff0c1-9\u3002 https:\/\/doi.org\/10.1371\/journal.pone.0042918<\/a><\/p>\n

Sullivan, T. (1999).A \u578b\u5c42\u86cb\u767d\u8868\u8fbe\u7684\u7f3a\u5931\u4f1a\u635f\u5bb3\u6838\u819c\u7684\u5b8c\u6574\u6027\uff0c\u4ece\u800c\u5bfc\u81f4\u808c\u8425\u517b\u4e0d\u826f\u75c7\u3002 \u7ec6\u80de\u751f\u7269\u5b66\u6742\u5fd7<\/em>, 147<\/em>(5), 913\u2013920\u3002 https:\/\/doi.org\/10.1083\/jcb.147.5.913<\/a><\/p>\n

[\/et_pb_toggle][et_pb_toggle title=” To Dr. Giovanna Lattanzi: 2 Questions and Answers for Dr. Lattanzi listed below.” open_toggle_background_color=”#f7f7f7″ closed_toggle_text_color=”#ffffff” closed_toggle_background_color=”#00b2e2″ icon_color=”#ffc15e” open_icon_color=”#ffc15e” admin_label=”Lattanzi Q&A 2″ _builder_version=”4.16″ _module_preset=”default” title_text_color=”#00b2e2″ title_font=”||||||||” background_color=”#ffffff” custom_margin=”||25px” custom_padding=”|50px||50px||true” border_width_all=”0px” global_colors_info=”{}”]<\/p>\n

\"\"\u95ee\u9898\uff1a<\/span> <\/strong>\u6765\u81ea Tom Misteli\uff1alonafarnib + tozilizumab \u5728\u52a8\u7269\u8eab\u4e0a\u7684\u6cbb\u7597\u6301\u7eed\u4e86\u591a\u957f\u65f6\u95f4\uff1f
\u56de\u7b54\uff1a<\/span> <\/strong>\u6211\u4eec\u4ece\u7b2c 22 \u5468\u5230\u7b2c 30 \u5468\u5bf9\u6742\u5408\u52a8\u7269\u8fdb\u884c\u4e86\u521d\u6b65\u5b9e\u9a8c\u3002\u6211\u4eec\u5e0c\u671b\u91cd\u70b9\u5173\u6ce8\u8fd9\u4e2a\u65f6\u95f4\u8303\u56f4\uff0c\u4ee5\u8bc4\u4f30\u4e4b\u524d\u4f7f\u7528\u6258\u73e0\u5355\u6297\u89c2\u5bdf\u5230\u7684\u5bf9\u4f53\u91cd\u589e\u52a0\u7684\u5f71\u54cd\u3002<\/p>\n

\u95ee\u9898\uff1a <\/strong><\/span>\u6765\u81ea Sgonzalo\uff1aGiovanna \u548c Sammy \u7684\u6545\u4e8b\u5f88\u7f8e\uff01\uff01\uff01\u4f60\u4eec\u770b\u5230\u6258\u73e0\u5355\u6297\u6cbb\u7597\u6709\u4ec0\u4e48\u526f\u4f5c\u7528\u5417\uff1f\u6216\u8005\u5728\u65e9\u8870\u75c7\u5c0f\u9f20\u4e2d\u6ca1\u6709\u6539\u5584\u7684\u4efb\u4f55\u8868\u578b\uff1f\u81f4 Giovanna Lattanzi \u535a\u58eb\uff1a\u95ee\u9898\uff1a\u6765\u81ea tom misteli\uff1alonafarnib + \u6258\u73e0\u5355\u6297\u5728\u52a8\u7269\u8eab\u4e0a\u7684\u6cbb\u7597\u6301\u7eed\u4e86\u591a\u957f\u65f6\u95f4\uff1f
\u56de\u7b54\uff1a <\/strong><\/span>\u8c22\u8c22 Susana\u3002\u4e0d\uff0c\u6211\u4eec\u6ca1\u6709\u770b\u5230\u6258\u73e0\u5355\u6297\u7684\u4efb\u4f55\u526f\u4f5c\u7528\u3002\u5728\u68c0\u67e5\u7684\u8868\u578b\u4e2d\uff08\u810a\u67f1\u540e\u51f8\u3001\u8102\u80aa\u7ec4\u7ec7\u8425\u517b\u4e0d\u826f\u3001\u6bdb\u53d1\u548c\u76ae\u80a4\u7f3a\u9677\u3001\u8fd0\u52a8\u6d3b\u52a8\u3001\u4e3b\u52a8\u8109\u75c5\u53d8\u548c\u5fc3\u808c\u80a5\u5927\uff09\u5747\u5f97\u5230\u4e86\u5ef6\u8fdf\/\u6539\u5584\u3002<\/p>\n

\u8bc4\u8bba\uff1a <\/strong><\/span>\u6765\u81ea MARIE GERHARD-HERMAN \uff1a\u5728\u7f8e\u56fd\u4e5f\u7528\u4e8e\u6cbb\u7597\u98ce\u6e7f\u75c5\u548c\u8840\u7ba1\u708e
\u56de\u590d\uff1a<\/span> <\/strong>\u611f\u8c22 Marie \u63d0\u4f9b\u6709\u5173\u8840\u7ba1\u708e\u6cbb\u7597\u7684\u6709\u8da3\u4fe1\u606f\u3002<\/p>\n

\u8bc4\u8bba\uff1a<\/span> <\/strong>\u6765\u81ea pc stefano\uff1a\u6258\u73e0\u5355\u6297\u5728\u65e5\u672c\u4e5f\u83b7\u6279\u7528\u4e8e\u6cbb\u7597 Castleman \u75c5\uff0c\u4e14\u65e0\u514d\u75ab\u6291\u5236\u4f5c\u7528
\u56de\u590d\uff1a <\/strong><\/span>\u611f\u8c22 Stefano \u63d0\u4f9b\u8fd9\u4e9b\u4fe1\u606f\u3002<\/p>\n

[\/et_pb_toggle][et_pb_toggle title=”To Dr. Minju Kim and Somi Kang who presented on behalf of Dr. Bum-Joon Park: 8 Questions and Answers for Dr. Minju Kim and Somi Kanglisted below.” open_toggle_background_color=”#f7f7f7″ closed_toggle_text_color=”#ffffff” closed_toggle_background_color=”#00b2e2″ icon_color=”#ffc15e” open_icon_color=”#ffc15e” admin_label=”Kim and Kang Q&A 6 questions” _builder_version=”4.16″ _module_preset=”default” title_text_color=”#00b2e2″ title_font=”||||||||” background_color=”#ffffff” custom_margin=”||25px” custom_padding=”|50px||50px||true” border_width_all=”0px” global_colors_info=”{}”]<\/p>\n

\"\"\"\" <\/strong><\/p>\n

\u95ee\u9898\uff1a<\/span> <\/strong>\u6765\u81ea Delphine Larrieu\uff1a\u60a8\u662f\u5426\u770b\u5230\u5728 HGPS \u7ec6\u80de\/HGPS \u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u4f7f\u7528\u65e9\u8001\u7d20\u6cbb\u7597\u540e\u7684 DNA \u635f\u4f24\u51cf\u5c11\uff1f
\u56de\u7b54\uff1a <\/strong><\/span>\u6211\u4eec\u89c2\u5bdf\u5230DNA\u4fee\u590d\u76f8\u5173\u57fa\u56e0\uff08BRCA1\u3001Rad51\u7b49\uff09\u5728\u4f7f\u7528progerinin\u6cbb\u7597\u540e\u53d1\u751f\u4e86\u6539\u53d8\u3002<\/p>\n

\u95ee\u9898\uff1a<\/strong> <\/span>Delphine Larrieu \u64b0\u6587\uff1a\u5b55\u6fc0\u7d20\u5982\u4f55\u5728 Werner \u4e2d\u53d1\u6325\u4f5c\u7528
\u636e\u6211\u6240\u77e5\uff0c\u8fd9\u79cd\u7efc\u5408\u5f81\u4e0d\u8868\u8fbe\u65e9\u8001\u7d20\uff1f\u8be5\u5206\u5b50\u8fd8\u6709\u5176\u4ed6\u9776\u70b9\u5417\uff1f
\u56de\u7b54\uff1a <\/strong><\/span>WS \u7ec6\u80de\u4e5f\u80fd\u50cf\u6b63\u5e38\u8001\u5e74\u4eba\u4e00\u6837\u4ea7\u751f\u5c11\u91cf\u7684\u65e9\u8870\u86cb\u767d
\u7ec6\u80de\u3002\u6211\u4eec\u5728 mRNA \u6c34\u5e73\u4e0a\u89c2\u5bdf\u5230\u4e86 WS \u7ec6\u80de\u4e2d\u65e9\u8001\u86cb\u767d\u7684\u8868\u8fbe\u3002
\u6211\u4eec\u8ba4\u4e3a WRN \u86cb\u767d\u53ef\u4ee5\u8d77\u5230\u6291\u5236\u65e9\u8870\u86cb\u767d\u7684\u4f5c\u7528\u3002\u7136\u800c\uff0c\u5728
\u5728 WS \u60a3\u8005\u4e2d\uff0c\u7531\u4e8e\u6ca1\u6709 WRN \u86cb\u767d\uff0c\u56e0\u6b64\u65e9\u8001\u86cb\u767d\u7684\u8868\u8fbe
\u88ab\u8ba4\u4e3a\u53d1\u751f\u5728 20 \u591a\u5c81\u548c 30 \u591a\u5c81\u4e4b\u95f4\uff0c\u4e0e\u6b63\u5e38\u5e74\u9f84\u7684\u4eba\u4e00\u6837\u591a
\u4eba\u4eec\u3002<\/p>\n

\u95ee\u9898\uff1a <\/strong><\/span>Bob Bishop \u8868\u793a\uff1a\u65e9\u8001\u7d20\u7ed3\u5408\u4f4d\u70b9\u662f\u5426\u7531\u751f\u5316\u5b9a\u4e49\uff0c\u6216\u8005
\u7ed3\u6784\u4e0a\uff1f\u662f\u5426\u6709\u751f\u5316\u68c0\u6d4b\u65b9\u6cd5\u53ef\u4ee5\u53d1\u73b0\u5176\u4ed6\u5316\u5408\u7269
\u6709\u8fd9\u4e2a\u673a\u5236\u5417\uff1f
\u56de\u7b54\uff1a <\/strong><\/span>\u6211\u4eec\u8fdb\u884c\u4e86\u751f\u7269\u7d20-\u4eb2\u548c\u7d20\u73e0\u4e0b\u62c9\u8bd5\u9a8c\uff0c\u5e76\u89c2\u5bdf\u5230
perogerin \u4e0e progerin \u6709\u7279\u5f02\u6027\u76f8\u4e92\u4f5c\u7528\uff0c\u4f46\u4e0e lamin A\u3001lamin
B\u3001p53 \u6216 emerin\u3002
\u6211\u4eec\u8fd8\u8fdb\u884c\u4e86 Elisa \u8bd5\u9a8c\uff0c\u4ee5\u627e\u5230\u53ef\u80fd
\u662f\u5047\u5b9a\u7684\u65e9\u8001\u86cb\u767d\/\u5c42\u86cb\u767d A \u7ed3\u5408\u6291\u5236\u5242\u3002\u5c06\u65e9\u8001\u86cb\u767d\u91cd\u7ec4\u86cb\u767d\u4f9d\u6b21\u4e0e\u5316\u5b66\u5e93\u548c\u5c42\u86cb\u767d A \u4e00\u8d77\u5b75\u80b2\u3002
\u7136\u800c\uff0cprogerinin \u662f\u5316\u5b66\u7269\u8d28\u4e2d\u6700\u6709\u6548\u7684\u5316\u5b66\u7269\u8d28
\u56fe\u4e66\u9986\u3002\"\"<\/p>\n

\"\"<\/p>\n

\u95ee\u9898\uff1a <\/strong><\/span>\u6765\u81ea John Cooke\uff1aKim \u535a\u58eb\uff0c\u8fdb\u6b65\u5f88\u5927\u3002Progerinin \u662f\u5426\u4f1a\u964d\u4f4e
SASP \u7ec6\u80de\u56e0\u5b50\u7684\u5206\u6ccc\uff1f
\u56de\u7b54\uff1a <\/strong><\/span>\u6211\u4eec\u89c2\u5bdf\u5230 progerinin \u53ef\u4ee5\u964d\u4f4e
HGPS \u5355\u5143\u3002<\/p>\n

\u95ee\u9898\uff1a <\/strong><\/span>\u6765\u81ea Susan Michaelis\uff1aprogerinin \u53ef\u4ee5\u4f9b\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u5417\uff1f
\u56de\u7b54\uff1a <\/strong><\/span>\u5f53\u7136\uff0c\u53ea\u8981\u4f60\u63d0\u51fa\u8981\u6c42\uff0c\u6211\u4eec\u5c31\u53ef\u4ee5\u4e3a\u4f60\u63d0\u4f9b\u3002<\/p>\n

\u95ee\u9898\uff1a <\/strong><\/span>\u6765\u81ea Thomas W Glover\uff1a\u6211\u53ef\u80fd\u9519\u8fc7\u4e86\uff0c\u4f46\u4f60\u8ba4\u4e3a
\u5bfc\u81f4\u6c83\u7eb3\u7efc\u5408\u5f81\u6709\u76ca\u6548\u679c\u7684\u673a\u5236\u662f\u4ec0\u4e48\uff1f
\u56de\u7b54\uff1a <\/strong><\/span>WS \u60a3\u8005\u6765\u6e90\u7684\u7ec6\u80de\u4e5f\u4f1a\u4ea7\u751f\u5c11\u91cf\u7684\u65e9\u8870\u86cb\u767d\uff0c\u56e0\u4e3a
\u4e0e\u6765\u81ea\u8001\u5e74\u4eba\u7684\u6b63\u5e38\u7ec6\u80de\u975e\u5e38\u76f8\u4f3c\u3002\u65e9\u8001\u7d20\u4e5f\u53ef\u4ee5
\u901a\u8fc7\u51cf\u5c11\u65e9\u8001\u7d20\u7684\u8868\u8fbe\u5bf9 WS \u7ec6\u80de\u6709\u6548\u3002<\/p>\n

[\/et_pb_toggle][et_pb_toggle title=”To Dr. Martin Berg\u00f6: Question: From Mario D. Cordero: Have you studied the effect about inflammation?” open_toggle_background_color=”#f7f7f7″ closed_toggle_text_color=”#ffffff” closed_toggle_background_color=”#00b2e2″ icon_color=”#ffc15e” open_icon_color=”#ffc15e” admin_label=”Dr. Martin Berg\u00f6” _builder_version=”4.16″ _module_preset=”default” title_text_color=”#00b2e2″ title_font=”||||||||” background_color=”#ffffff” custom_margin=”||25px” custom_padding=”|50px||50px||true” border_width_all=”0px” global_colors_info=”{}”]<\/p>\n

\"\"\u56de\u7b54\uff1a <\/strong>\u8c22\u8c22\u4f60\u7684\u63d0\u95ee\uff1a\u4e0d\uff0c\u4e0d\u662f\u708e\u75c7\u672c\u8eab\u3002\u90e8\u5206\u4e0e\u708e\u75c7\u6709\u5173\uff0c\u6211\u4eec\u5728\u672c\u9879\u76ee\u4e2d\u7814\u7a76\u4e86\u5de8\u566c\u7ec6\u80de\uff0c\u53d1\u73b0\u6572\u9664\u00a0\u514d\u75ab\u5b66<\/i>\u00a0\u589e\u52a0\u5de8\u566c\u7ec6\u80de\u80c6\u56fa\u9187\u6d41\u51fa\uff0c\u5305\u62ec\u57fa\u7840\u80c6\u56fa\u9187\u548c ApoAI \u548c HDL \u523a\u6fc0\u7684\u80c6\u56fa\u9187\u6d41\u51fa\u3002\u7531\u4e8e\u8fd9\u79cd\u5f71\u54cd\u6709\u65f6\u4e0e\u4f53\u5185\u80c6\u56fa\u9187\u9006\u5411\u8f6c\u8fd0\u589e\u52a0\u6709\u5173\uff0c\u6211\u4eec\u60f3\u786e\u5b9a\u00a0\u514d\u75ab\u5b66<\/i>\u00a0\u6291\u5236\u4f1a\u51cf\u5c11\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u53d1\u5c55\u3002<\/p>\n

[\/et_pb_toggle][et_pb_toggle title=”To Dr. David Liu: Question: 3 Questions and Answers for Dr. Lui listed below.” open_toggle_background_color=”#f7f7f7″ closed_toggle_text_color=”#ffffff” closed_toggle_background_color=”#00b2e2″ icon_color=”#ffc15e” open_icon_color=”#ffc15e” admin_label=”Dr. David Liu Q&A 3″ _builder_version=”4.16″ _module_preset=”default” title_text_color=”#00b2e2″ title_font=”||||||||” background_color=”#ffffff” custom_margin=”||25px” custom_padding=”|50px||50px||true” border_width_all=”0px” global_colors_info=”{}”]<\/p>\n

\"\"<\/p>\n

\u95ee\u9898\uff1a <\/strong><\/span>\u6765\u81ea vandres\uff1a\u60a8\u662f\u5426\u5c1d\u8bd5\u8fc7\u5728\u4e0d\u540c\u5e74\u9f84\u7684\u4eba\u7c7b HGPS \u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u8fdb\u884c DNA \u6821\u6b63\uff08\u4f53\u5916\uff09\uff0c\u5e76\u6d4b\u8bd5\u5176\u8868\u578b\u7684\u6b63\u5e38\u5316\uff0c\u770b\u770b\u5b83\u662f\u5426\u4f1a\u968f\u7740\u7ec6\u80de\u8001\u5316\u800c\u964d\u4f4e\uff1f
\u56de\u7b54\uff1a<\/span> <\/strong>\u4e0d\uff0c\u6211\u4eec\u6ca1\u6709\u5c1d\u8bd5\u5bf9\u6765\u81ea\u4e0d\u540c\u5e74\u9f84\u6bb5\u60a3\u8005\u7684\u6210\u7ea4\u7ef4\u7ec6\u80de\u8fdb\u884c\u77eb\u6b63\u2014\u2014\u4ec5\u5bf9\u4e24\u4e2a\u4e0d\u540c\u7684\u60a3\u8005\u8fdb\u884c\u4e86\u77eb\u6b63\uff0c\u7ed3\u679c\u76f8\u4f3c\u3002<\/p>\n

\u95ee\u9898\uff1a<\/strong> <\/span>Delphine Larrieu \u8868\u793a\uff1a\u6548\u679c\u60ca\u4eba\uff01\u60a8\u8ba4\u4e3a\u6742\u5408\u5b50\u5c0f\u9f20\u4e2d\u65e9\u8870\u86cb\u767d\u4f1a\u88ab\u5b8c\u5168 KO \u5417\uff1f
\u56de\u7b54\uff1a<\/span> <\/strong>\u5728\u5355\u62f7\u8d1d\u5c0f\u9f20\u4e2d\uff0c\u6211\u4e0d\u4f1a\u671f\u671b\u7f16\u8f91\u6548\u7387\u4e0e\u6211\u4eec\u76ee\u524d\u89c2\u5bdf\u5230\u7684\u6709\u592a\u5927\u5dee\u5f02\uff0c\u56e0\u4e3a\u6bcf\u4e2a\u65e9\u8870\u86cb\u767d\u5e94\u8be5\u5df2\u7ecf\u6709\u8fc7\u91cf\u7684\u7f16\u8f91\u5242\u3002<\/p>\n

\u95ee\u9898\uff1a <\/span><\/strong>\u6765\u81ea Andre Monteiro Da Rocha\uff1a\u60a8\u662f\u5426\u8ba4\u4e3a\u5bf9\u4f4e\u6bd4\u4f8b\u7684\u7ec6\u80de\u8fdb\u884c\u91cd\u65b0\u7f16\u7a0b\u53ef\u4ee5\u4fee\u590d\u5e72\u7ec6\u80de\u529f\u80fd\uff0c\u4f46\u53ef\u80fd\u4f1a\u5bfc\u81f4\u6210\u4f53\u5e72\u7ec6\u80de\u8870\u7aed\uff1f
\u56de\u7b54\uff1a<\/span> <\/strong>\u6211\u4eec\u6ca1\u6709\u4efb\u4f55\u6570\u636e\u53ef\u4ee5\u56de\u7b54\u8fd9\u4e2a\u95ee\u9898\u3002<\/p>\n

[\/et_pb_toggle][et_pb_toggle title=”To Dr. Colin Stewart: 8 Questions and Answers for Dr. Stewart listed below.” open_toggle_background_color=”#f7f7f7″ closed_toggle_text_color=”#ffffff” closed_toggle_background_color=”#00b2e2″ icon_color=”#ffc15e” open_icon_color=”#ffc15e” admin_label=”Dr. Colin Stewart” _builder_version=”4.16″ _module_preset=”default” title_text_color=”#00b2e2″ title_font=”||||||||” background_color=”#ffffff” custom_margin=”||25px” custom_padding=”|50px||50px||true” border_width_all=”0px” global_colors_info=”{}”]<\/p>\n

\"\"\u95ee\u9898\uff1a<\/strong><\/span> \u6765\u81ea\u6885\uff1a\u770b\u8d77\u6765\u50cf\u5fc3\u808c\u7ec6\u80de\uff0c\u67d3\u8272\u5f88\u6f02\u4eae\uff01
\u6765\u81ea Abby Buchwalter\uff1a\u663e\u6027\u8d1f\u6027 Sun1 \u8868\u8fbe\u662f\u5426\u4f1a\u7834\u574f\u6240\u6709 LINC \u590d\u5408\u7269\uff0c\u5305\u62ec\u7531 Sun2 \u4ecb\u5bfc\u7684\u590d\u5408\u7269\uff1f
\u56de\u7b54\uff1a<\/span> <\/strong>\u662f\u7684\uff0c\u6709\u4f53\u5916\u8bc1\u636e\u8868\u660e\uff0cNE \u4e2d\u7684\u6240\u6709 Nesprins \u90fd\u53ef\u4ee5\u88ab DNSUN1 \u53d6\u4ee3<\/p>\n

\u95ee\u9898\uff1a<\/strong><\/span> \u6765\u81ea Suet Nee Chen\uff1aAAV9-SunDn \u80fd\u591f\u4ea7\u751f\u957f\u671f\u6548\u679c\u7684\u673a\u5236\u662f\u4ec0\u4e48\uff1f\u60a8\u5728\u4ec0\u4e48\u5e74\u9f84\u5c06 AAV9-Sun1DN \u6ce8\u5c04\u5230 LMNA \u7a81\u53d8\u5c0f\u9f20\u4f53\u5185\uff1f
\u56de\u7b54\uff1a<\/span> <\/strong>\u6211\u4eec\u5728\u8bf1\u5bfc Cre \u91cd\u7ec4\u9176\u5220\u9664\u5c42\u86cb\u767d A \u540e\u4e00\u5929\u6ce8\u5c04\u4e86 DNSUN1 AAV\u3002\u6211\u4eec\u6709\u6570\u636e\u8868\u660e\uff0cAAV \u9012\u9001\u7684 DNSUN1 \u5728\u6ce8\u5c04\u4e00\u5e74\u540e\u4ecd\u5728\u5fc3\u808c\u7ec6\u80de\u4e2d\u8868\u8fbe\u3002\u73b0\u5728\u6211\u4eec\u56de\u5230\u5b9e\u9a8c\u5ba4\uff0c\u53ef\u4ee5\u81ea\u884c\u5236\u9020\u8db3\u591f\u6570\u91cf\u7684 AAV\uff0c\u6211\u4eec\u6b63\u5728\u8fdb\u884c\u5242\u91cf\/\u65f6\u95f4\/\u53cd\u5e94\u5b9e\u9a8c<\/p>\n

\u95ee\u9898\uff1a<\/span><\/strong> \u6765\u81ea Viceordf\u00f6rande Kommitt\u00e9n forskning \u7684 Martin Berg\u00f6\uff1a\u60a8\u8ba4\u4e3a\u5728 Lmna \u6572\u9664\u5b9e\u9a8c\u4e2d\u7f3a\u5931\u6838\u7ea4\u5c42\u86cb\u767d A \u4e0e\u6838\u7ea4\u5c42\u86cb\u767d C \u7684\u76f8\u5bf9\u8d21\u732e\u662f\u4ec0\u4e48\uff1f
\u56de\u7b54\uff1a<\/strong><\/span> \u6211\u5bf9\u6b64\u5e76\u4e0d\u786e\u5b9a\uff0c\u4f46 Sun1 \u4e0e LaminA \u76f8\u4e92\u4f5c\u7528\uff0c\u5e76\u4e14\u5728 HGPS \u5c0f\u9f20\u4e2d\uff0c\u8d21\u732e\u5fc5\u987b\u5168\u90e8\u6765\u81ea LaminA\uff08progerin \u7531\u6b64\u884d\u751f\uff09<\/p>\n

\u95ee\u9898\uff1a<\/span><\/strong> \u6765\u81ea jcampisi\uff1aSUN1 KO \u6216 hets \u7684\u6b7b\u56e0\u662f\u4ec0\u4e48\uff1f
\u56de\u7b54\uff1a<\/strong><\/span> \u597d\u95ee\u9898\uff0c\u6211\u4eec\u4ecd\u7136\u4e0d\u77e5\u9053\uff0c\u4f46\u76ee\u524d\u6000\u7591\u4e00\u4e9b\u9aa8\u9abc\u808c\u7fa4\u6211\u4eec\u9700\u8981\u5bf9\u5782\u6b7b\u7684\u8001\u9f20\u8fdb\u884c\u9002\u5f53\u7684\u7ec4\u7ec7\u75c5\u7406\u5206\u6790<\/p>\n

\u95ee\u9898\uff1a <\/span><\/strong>\u6765\u81ea Tom Misteli\uff1aColin\uff1a\u60a8\u662f\u5426\u770b\u5230\u8fc7 Lmna\/Sun \u52a8\u7269\u7684\u7ec6\u80de\u5e94\u6fc0\u53cd\u5e94\u9014\u5f84\u7684\u53d8\u5316\uff1f
\u56de\u7b54\uff1a<\/strong><\/span> \u6211\u4eec\u5c1a\u672a\u6d4b\u91cf\u8fd9\u4e9b\u5c0f\u9f20\u7684\u4efb\u4f55\u5e94\u6fc0\u53cd\u5e94\u57fa\u56e0\/\u6807\u8bb0<\/p>\n

\u95ee\u9898\uff1a\u6765\u81ea Delphine Larrieu\uff1a\u60a8\u662f\u5426\u8bbe\u60f3\u4ec5\u9488\u5bf9 HGPS \u60a3\u8005\u7684\u5fc3\u810f\u4f7f\u7528 DNSUN1\uff1f
\u56de\u7b54\uff1a<\/strong><\/span> \u9274\u4e8e\u8840\u6e05\u578b\u548c\u5fc3\u808c\u7ec6\u80de\u7279\u5f02\u6027\u542f\u52a8\u5b50\u7684\u4f7f\u7528\uff0c\u8fd9\u662f\u53ef\u80fd\u7684\u3002\u8fd9\u4e9b\u5b9e\u9a8c\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u4e2d<\/p>\n

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