Lonafarnib Pre-clinical Drug Supply Program
July 2015: Lonafarnib Now Available for Research
PRF is making the farnesyltransferase inhibitor lonafarnib available to the research community. Our goal is to support preclinical studies to further investigate the effects of lonafarnib on Progeria.
It is PRF’s steadfast mission to find better treatments and a cure for children with Progeria. Lonafarnib has been shown to benefit some aspects of the disease clinically, (Gordon et al, PNAS, 2012) as well as influence increased estimated lifespan, (Gordon et al, Circulation, 2014) but it is not curative. As new compounds are identified with the potential to ameliorate HGPS, we anticipate the need to test these compounds in combination with lonafarnib in vitro and in animal models.
Many thanks to the pharmaceutical company Merck for making this program possible.
The material is supplied at no cost. Recipient pays for all shipping charges. To receive lonafarnib, please fill out an application and material transfer agreement, and submit to firstname.lastname@example.org
** PRF has a policy of no changes to our MTA.
Contacts for Questions and Assistance:
Principal Investigator: Leslie B. Gordon, MD, PhD; email@example.com
Research Study Coordinator: Joan Brazier; firstname.lastname@example.org
For U.S. Federal Government Institutions or questions, please contact Joan Brazier, Research Study Coordinator, at email@example.com or 401-863-9628.