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Science-driven.
Patient-focused.

Progeria is an ultra-rare, fatal genetic disease characterized by an appearance of accelerated aging. PRF is the only research organization in the world dedicated exclusively to finding treatments and the cure.

Learn About PRF

Learn About Progeria

FEATURED PROGRAM

PRF is advancing a first-of-its-kind Progeria gene-editing therapy through clinical trials to help us determine if this approach is our path to the cure.

Learn more

Research & Drug Development

WE DON'T WAIT
FOR CURES.
WE BUILD THEM.

PRF provides the leadership, infrastructure, and global coordination to advance discoveries into therapies.

Clinical Trials

Care &
Community

NO FAMILY
WALKS THIS
PATH ALONE.

From the moment of diagnosis through long-term care, PRF connects families with trusted medical guidance, peer support, and a global family who truly understands the unique needs of those affected by Progeria.

Community Resources

Latest News

Progeria Research Foundation to Honor Gene-Editing Pioneer David R. Liu, Ph.D., and Peabody Philanthropists Cathy and Dave Gravel at 2026 Night of Wonder Gala

October 7, 2026 Base-editing innovator and longtime local supporters to receive PRF’s S.A.M. Award and Amy Award at biennial signature…

PRF’s 12th International Scientific Workshop

October 29-31, 2025 A landmark meeting summary from the 12th International PRF Scientific Workshop has just been published in Nature…

PRF Announces Manufacturing Partnership with Forge Biologics to Advance Progeria Gene Therapy!

March 3, 2026 PRF Announces Manufacturing Partnership with Forge Biologics to Advance Progeria Gene Therapy! This announcement marks a major…

Upcoming Events

Night of Wonder 2026

Saturday, November 14, 2026 Westin Boston Seaport District Boston, MA WHAT: Held just once every two years, it’s time for NIGHT…

Boston Marathon 2027

The Progeria Research Foundation is proud to be a part of the 131st Boston Marathon® presented by Bank of America,…

25+ Years of Impact –
because of donors like you

For more than 25 years, PRF has been setting the standard for ultrarare disease research. Donor and volunteer support has made it possible to identify and support children and families worldwide, fund critical research, and develop therapies that would not exist otherwise. When no clear path from discovery to treatment existed, we built one.

And we’re not done.

VIEW OUR IMPACT