Vision
Our vision is a world in which every child with Progeria is cured.
Mission
To discover treatments and the cure for Progeria and its aging-related disorders, including heart disease.
Vision
Our vision is a world in which every child with Progeria is cured.
Mission
To discover treatments and the cure for Progeria and its aging-related disorders, including heart disease.
Progeria is an ultra-rare, fatal, “rapid-aging” disease that afflicts children who, without the FDA-approved treatment lonafarnib, die of heart disease at an average age of 14.5 years. PRF is the only non-profit organization solely dedicated to finding treatments and the cure for Progeria, and is making phenomenal progress toward that goal.
News
PRF’s 12th International Scientific Workshop
A landmark meeting summary from the 12th International PRF Scientific Workshop has just been published in Nature Aging.
NEWS RELEASE: FOR IMMEDIATE RELEASE
The Progeria Research Foundation Celebrates 25 Years of Racing Toward a Cure 25th Annual International Race for Research Set for September 19, 2026, in Peabody, MA.
Come join us and hit the streets for the City of Peabody’s largest annual road race. We’re excited to mark this special milestone with our incredible community.
ONEpossible 2026 June 1-July 15. Everywhere
PRF is now advancing SamPro-2, a gene editing therapy that has permanently corrected the exact DNA error that causes Progeria in mouse models, toward human trials.
This is the moment everything changes. And you can be ONE to make the cure POSSIBLE!
PRF Announces Manufacturing Partnership with Forge Biologics to Advance Progeria Gene Therapy!
PRF Announces Manufacturing Partnership with Forge Biologics to Advance Progeria Gene Therapy!
This announcement marks a major milestone: PRF has entered into a manufacturing agreement with Forge Biologics to produce SamPro-2, its gene editing therapy in development for children and young adults with Progeria — an essential step toward clinical trials and, ultimately, the cure!
Get PRF’s 2025 Newletter here!
Hot off the press: PRF’s 2025 Newsletter! Get the latest scoop on the Progerinin Clinical Trial, our Path to CURE PROGERIA, and so much more!
Get Involved
Our lonafarnib clinical trials enrolled 107 children from 42 different countries to test this now-FDA-approved treatment. Because of your support, these children and young adults are living longer, healthier lives.
About PRF
Your donation helps The Progeria Research Foundation treat children with Progeria today, and cure them in the future.
Meet the Kids
We hope their stories inspire you to support PRF, so those dreams can come true.
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