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Note: Agenda Subject to Change
Wednesday, October 29, 2025
Time Session Conférencier
  3:00-8:30 PM   Registration Desk Open & Poster Set-Up
  5:00-5:10 PM   Présentation et salutations de la PRF   Medical Director Leslie Gordon, MD, PhD,
Executive Director Audrey Gordon, Esq.,
Board Chair Scott Berns, MD, MPH, FAAP
  5:10-5:15 PM   Sponsor Remarks   Riccardo Zanolli
  5:15-6:15 PM   “Coming of Age” Conversations:  Young Adults with HGPS as Research Partners   Moderator: Merlin Waldron
Riccardo Zanolli
Nathan Falcone
  Michiel Vandeweert
  6:15-6:30 PM   Musical Kickoff   Dr Francis Collins, Ph. D.
  6:30-7:30 PM   Dinner & Networking
  7:30-8:30 PM   Affiche ronde éclair
Thursday, October 30, 2025
  7:15 AM-8:30 PM Registration Desk Open
  7:30-9:00 AM Bridging the Bench Mentor Session   Breakfast
 Résultats des essais thérapeutiques actuels sur la progéria       Moderator: Mark Keiran, MD
  9:00-9:20 AM Essai de traitement à long terme par lonafarnib sur l'histoire naturelle   Dr Leslie Gordon, Ph. D.
  9:20-9:40 AM Essai clinique de phase 2a sur la progérine dans le traitement de la progéria   Dr Monica Kleinman
  9:40-10:00 AM Break  
 10:00-10:20 AM Tools for Pivotal Science and Medicine in Progeria: Biomarker Assay Development, Qualification and Reagent Generation   Barbara Natke, Ph. D.
 10:20-10:40 AM Evaluation of Coronary Artery and Aortic Calcium by Computed Tomography in Progeria   Dr Sunil Ghelani
 10:40-12:00 PM Lunch  
Cardiovascular Disease in HGPS and Aging       Moderator: Maria Eriksson, PhD
 12:00-12:20 PM Single-cell Analysis Reveals the Phenotypic Landscape of Arterial Cells in Progeria   Maria Eriksson, Ph. D.
 12:20-12:40 PM Title To Be Announced   Dr Shannon Lyon
 12:40-1:00 PM Angiopoietin-2: A Potential Therapeutic Target for Vascular Protection in Hutchinson-Gilford Progeria Syndrome   Kan Cao, Ph. D.
  1:00-1:20 PM Break  
  1:20-1:40 PM Progeria et calcification vasculaire : régime alimentaire et traitements   Ricardo Villa Bellosta, Ph. D.
  1:40-2:00 PM Title To Be Announced   Ashwin Prakash, MD
  2:00-2:20 PM Title To Be Announced  
  2:20-3:00 PM Break  
  5:00-6:30 PM Dinner & Networking
  6:30-7:30 PM Poster Session Part 1   Even Numbered Posters
  7:30-8:30 PM Poster Session Part 2   Odd Numbered Posters
Friday, October 31, 2025
  8:00 AM-2:00 PM Registration Desk Open
  8:00-9:00 AM Breakfast & Networking

Progeria Treatment Discovery for a Healthy Future       Moderator: Francis Collins, MD, PhD

  9:00-9:20 AM Title To Be Announced   David Liu, Ph. D.
  9:20-9:40 AM ProSPER: PROgeria Streamlined Platform Gene Editing for Rare diseases   David Liu, PhD & Francis Collins, MD, PhD
  9:40-10:00 AM Development of Gene Silencing (RNAi) and Gene Editing Therapeutics for Hutchinson-Gilford Progeria Syndrome (HGPS)   Nizar Saad, Ph. D.
 10:00-10:20 AM Break  
 10:20-11:00 AM AI-driven Therapeutic Antisense Oligonucleotide for Hutchinson-Gilford Progeria   Ning Shen, Ph. D.
 11:00-11:20 AM First-Generation PROTACs for Improving Progeria Phenotype   Silvia Ortega Gutierrez, Ph. D.
 11:20-12:20 PM Lunch & Networking
Endocrine and GI Disease in Progeria       Moderator: Vicente Andres, PhD
 12:20-12:40 PM Lipodistrophy and Cardiovascular Pathology in Hutchinson-Gilford Progeria Syndrome   Vicente Andres, PhD
 12:40-1:00 PM Unraveling Accelerated Intestinal Ageing in HGPS Physiopathology: An Integrative Approach   Laurence Arbibe, Ph. D.
  1:00-1:20 PM Targeting Inflammation to Ameliorate HGPS Pathologies   Susana Gonzalo, Ph. D.
  1:20-1:40 PM Break  
  1:40-2:40 PM

Bilan de l'atelier
All-hands meeting discussion on key findings and highest priorities for future success.

  Dr Leslie Gordon, Ph. D.
  Dr Francis Collins, Ph. D.
  Mark Keiran, MD

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